-- dump date 20140620_024714 -- class Genbank::misc_feature -- table misc_feature_note -- id note 216596000001 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 216596000002 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 216596000003 P-loop; other site 216596000004 Magnesium ion binding site [ion binding]; other site 216596000005 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 216596000006 Magnesium ion binding site [ion binding]; other site 216596000007 Pfam match to entry PF01656.8 CbiA, score 178.0,E-value 1.9e-50 216596000008 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 216596000009 ParB-like nuclease domain; Region: ParB; smart00470 216596000010 Pfam match to entry PF02195.5 ParBc, score 95.0,E-value 1.9e-25 216596000011 Pfam match to entry PF07506.1 RepB, score 79.0,E-value 1.2e-20 216596000012 replication initiation protein RepC; Provisional; Region: PRK13824 216596000013 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216596000014 putative DNA binding site [nucleotide binding]; other site 216596000015 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 216596000016 Pfam match to entry PF03428.3 RP-C, score 752.4,E-value 2.4e-223 216596000017 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 216596000018 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 216596000019 inhibitor site; inhibition site 216596000020 active site 216596000021 dimer interface [polypeptide binding]; other site 216596000022 catalytic residue [active] 216596000023 Pfam match to entry PF00701.10 DHDPS, score 40.9,E-value 2e-13 216596000024 Transcriptional regulators [Transcription]; Region: GntR; COG1802 216596000025 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 216596000026 DNA-binding site [nucleotide binding]; DNA binding site 216596000027 FCD domain; Region: FCD; pfam07729 216596000028 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 216596000029 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 216596000030 Pfam match to entry PF01547.11 SBP_bac_1, score 59.8, E-value 7.7e-15 216596000031 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596000032 dimer interface [polypeptide binding]; other site 216596000033 conserved gate region; other site 216596000034 putative PBP binding loops; other site 216596000035 ABC-ATPase subunit interface; other site 216596000036 6 probable transmembrane helices predicted at aa 28-50, 88-110, 122-144,181-198, 219-238 and 276-298 216596000037 Pfam match to entry PF00528.10 BPD_transp_1, score 55.9, E-value 1.1e-13 216596000038 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216596000039 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596000040 putative PBP binding loops; other site 216596000041 ABC-ATPase subunit interface; other site 216596000042 6 probable transmembrane helices predicted at aa 9-31, 73-95, 107-129, 139-158,192-214 and 234-256 216596000043 Pfam match to entry PF00528.10 BPD_transp_1, score 60.2, E-value 5.7e-15 216596000044 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 216596000045 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 216596000046 substrate binding site [chemical binding]; other site 216596000047 ATP binding site [chemical binding]; other site 216596000048 Pfam match to entry PF00294.10 PfkB, score 143.1,E-value 6.2e-40 216596000049 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 216596000050 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 216596000051 1 probable transmembrane helix predicted at aa 13-32 216596000052 Pfam match to entry PF01547.11 SBP_bac_1, score 69.5, E-value 8.6e-18 216596000053 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 216596000054 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596000055 dimer interface [polypeptide binding]; other site 216596000056 conserved gate region; other site 216596000057 putative PBP binding loops; other site 216596000058 ABC-ATPase subunit interface; other site 216596000059 6 probable transmembrane helices predicted at aa 12-34, 71-93, 106-128,157-179, 206-228 and 266-288 216596000060 Pfam match to entry PF00528.10 BPD_transp_1, score 35.8, E-value 1.3e-07 216596000061 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216596000062 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596000063 dimer interface [polypeptide binding]; other site 216596000064 conserved gate region; other site 216596000065 putative PBP binding loops; other site 216596000066 ABC-ATPase subunit interface; other site 216596000067 7 probable transmembrane helices predicted at aa 7-29, 83-105, 112-131,146-168, 189-211, 216-235 and 248-270 216596000068 Pfam match to entry PF00528.10 BPD_transp_1, score 72.7, E-value 1e-18 216596000069 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 216596000070 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 216596000071 Walker A/P-loop; other site 216596000072 ATP binding site [chemical binding]; other site 216596000073 Q-loop/lid; other site 216596000074 ABC transporter signature motif; other site 216596000075 Walker B; other site 216596000076 D-loop; other site 216596000077 H-loop/switch region; other site 216596000078 TOBE domain; Region: TOBE_2; pfam08402 216596000079 Pfam match to entry PF00005.11 ABC_tran, score 225.1, E-value 1.3e-64 216596000080 Pfam match to entry PF03459.4 TOBE, score 25.0,E-value 3.8e-06 216596000081 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 216596000082 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 216596000083 putative active site [active] 216596000084 catalytic site [active] 216596000085 putative metal binding site [ion binding]; other site 216596000086 Pfam match to entry PF03009.6 GDPD, score 169.5,E-value 7.2e-48 216596000087 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 216596000088 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 216596000089 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 216596000090 Pfam match to entry PF00455.10 DeoR, score 209.6,E-value 5.9e-60 216596000091 Predicted helix-turn-helix motif with score 1700.000, SD 4.98 at aa 23-44, sequence QYIEELARRYDLTTQTIRRDIN 216596000092 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 216596000093 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 216596000094 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216596000095 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596000096 dimer interface [polypeptide binding]; other site 216596000097 conserved gate region; other site 216596000098 putative PBP binding loops; other site 216596000099 ABC-ATPase subunit interface; other site 216596000100 Pfam match to entry PF00528.10 BPD_transp_1, score 54.6, E-value 2.7e-13 216596000101 6 probable transmembrane helices predicted at aa 13-35, 79-101, 113-135,145-167, 188-210 and 248-265 216596000102 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596000103 dimer interface [polypeptide binding]; other site 216596000104 conserved gate region; other site 216596000105 putative PBP binding loops; other site 216596000106 ABC-ATPase subunit interface; other site 216596000107 Pfam match to entry PF00528.10 BPD_transp_1, score 48.1, E-value 2.5e-11 216596000108 6 probable transmembrane helices predicted at aa 46-68, 106-128, 141-163,196-218, 239-261 and 298-320 216596000109 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 216596000110 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 216596000111 Pfam match to entry PF01547.11 SBP_bac_1, score 86.2, E-value 8.5e-23 216596000112 Transcriptional regulators [Transcription]; Region: PurR; COG1609 216596000113 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216596000114 DNA binding site [nucleotide binding] 216596000115 domain linker motif; other site 216596000116 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 216596000117 dimerization interface [polypeptide binding]; other site 216596000118 ligand binding site [chemical binding]; other site 216596000119 Predicted helix-turn-helix motif with score 1674.000, SD 4.89 at aa 7-28, sequence KSMDDFATAAGVSRPTLSKYFD 216596000120 Pfam match to entry PF00532.8 Peripla_BP_1, score 26.9, E-value 7.3e-06 216596000121 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 216596000122 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 216596000123 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 216596000124 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 216596000125 Pfam match to entry PF01408.8 GFO_IDH_MocA, score 99.7, E-value 7.3e-27 216596000126 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 216596000127 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 216596000128 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 216596000129 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 216596000130 Pfam match to entry PF00455.10 DeoR, score 186.8,E-value 4.3e-53 216596000131 Predicted helix-turn-helix motif with score 1087.000, SD 2.89 at aa 20-41, sequence ARTRQLAEFFEVSEVTIRSDLE 216596000132 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 216596000133 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 216596000134 putative active site; other site 216596000135 catalytic residue [active] 216596000136 Pfam match to entry PF01791.6 DeoC, score 38.6,E-value 6.9e-10 216596000137 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 216596000138 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 216596000139 substrate binding site [chemical binding]; other site 216596000140 ATP binding site [chemical binding]; other site 216596000141 Pfam match to entry PF00294.10 PfkB, score 106.4,E-value 7.1e-29 216596000142 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 216596000143 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 216596000144 Walker A/P-loop; other site 216596000145 ATP binding site [chemical binding]; other site 216596000146 Q-loop/lid; other site 216596000147 ABC transporter signature motif; other site 216596000148 Walker B; other site 216596000149 D-loop; other site 216596000150 H-loop/switch region; other site 216596000151 TOBE domain; Region: TOBE_2; pfam08402 216596000152 Pfam match to entry PF00005.11 ABC_tran, score 212.0, E-value 1.1e-60 216596000153 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 216596000154 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 216596000155 Pfam match to entry PF01408.8 GFO_IDH_MocA, score 130.2, E-value 4.8e-36 216596000156 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 216596000157 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 216596000158 Metal-binding active site; metal-binding site 216596000159 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 216596000160 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 216596000161 catalytic site [active] 216596000162 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 216596000163 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 216596000164 substrate binding site [chemical binding]; other site 216596000165 hexamer interface [polypeptide binding]; other site 216596000166 metal binding site [ion binding]; metal-binding site 216596000167 Pfam match to entry PF00834.7 Ribul_P_3_epim, score 77.8, E-value 2.8e-20 216596000168 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 216596000169 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 216596000170 nucleotide binding site [chemical binding]; other site 216596000171 Pfam match to entry PF00480.8 ROK, score 185.8,E-value 8.5e-53 216596000172 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 216596000173 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 216596000174 Pfam match to entry PF01547.11 SBP_bac_1, score 160.5, E-value 3.6e-45 216596000175 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216596000176 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596000177 dimer interface [polypeptide binding]; other site 216596000178 conserved gate region; other site 216596000179 putative PBP binding loops; other site 216596000180 ABC-ATPase subunit interface; other site 216596000181 6 probable transmembrane helices predicted at aa 34-56, 109-130, 137-159,193-215, 236-258 and 296-318 216596000182 Pfam match to entry PF00528.10 BPD_transp_1, score 41.0, E-value 3.4e-09 216596000183 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216596000184 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596000185 dimer interface [polypeptide binding]; other site 216596000186 conserved gate region; other site 216596000187 putative PBP binding loops; other site 216596000188 ABC-ATPase subunit interface; other site 216596000189 6 probable transmembrane helices predicted at aa 9-31, 71-93, 100-122, 137-159,180-202 and 238-260 216596000190 Pfam match to entry PF00528.10 BPD_transp_1, score 53.1, E-value 8e-13 216596000191 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 216596000192 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 216596000193 Walker A/P-loop; other site 216596000194 ATP binding site [chemical binding]; other site 216596000195 Q-loop/lid; other site 216596000196 ABC transporter signature motif; other site 216596000197 Walker B; other site 216596000198 D-loop; other site 216596000199 H-loop/switch region; other site 216596000200 TOBE domain; Region: TOBE_2; pfam08402 216596000201 Pfam match to entry PF00005.11 ABC_tran, score 218.6, E-value 1.2e-62 216596000202 Pfam match to entry PF03459.4 TOBE, score 40.4,E-value 5e-09 216596000203 Trehalose utilization protein [Carbohydrate transport and metabolism]; Region: ThuA; COG4813 216596000204 conserved cys residue [active] 216596000205 Pfam match to entry PF06283.1 DUF1037, score 601.0, E-value 8.7e-178 216596000206 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 216596000207 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 216596000208 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 216596000209 Pfam match to entry PF01408.8 GFO_IDH_MocA, score 119.7, E-value 6.8e-33 216596000210 Pfam match to entry PF02894.4 GFO_IDH_MocA_C, score 10.3, E-value 0.038 216596000211 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 216596000212 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR9; cd08274 216596000213 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 216596000214 putative NAD(P) binding site [chemical binding]; other site 216596000215 Pfam match to entry PF00107.11 ADH_zinc_N, score 177.8, E-value 2.2e-50 216596000216 hypothetical protein; Provisional; Region: PRK07482 216596000217 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 216596000218 inhibitor-cofactor binding pocket; inhibition site 216596000219 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596000220 catalytic residue [active] 216596000221 Pfam match to entry PF00202.8 Aminotran_3, score 283.3, E-value 3.9e-82 216596000222 succinic semialdehyde dehydrogenase; Region: PLN02278 216596000223 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 216596000224 tetramerization interface [polypeptide binding]; other site 216596000225 NAD(P) binding site [chemical binding]; other site 216596000226 catalytic residues [active] 216596000227 Pfam match to entry PF00171.9 Aldedh, score 622.9, E-value 2.3e-184 216596000228 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 216596000229 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216596000230 putative DNA binding site [nucleotide binding]; other site 216596000231 putative Zn2+ binding site [ion binding]; other site 216596000232 AsnC family; Region: AsnC_trans_reg; pfam01037 216596000233 Pfam match to entry PF01037.8 AsnC_trans_reg, score 113.5, E-value 5.3e-31 216596000234 Predicted helix-turn-helix motif with score 1048.000, SD 2.76 at aa 20-41, sequence ITKLALAEKAGLSPTPCWMRLR 216596000235 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 216596000236 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596000237 DNA-binding site [nucleotide binding]; DNA binding site 216596000238 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216596000239 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596000240 homodimer interface [polypeptide binding]; other site 216596000241 catalytic residue [active] 216596000242 Pfam match to entry PF00392.9 GntR, score 32.9,E-value 9.3e-07 216596000243 Predicted helix-turn-helix motif with score 1129.000, SD 3.03 at aa 53-74, sequence PPHRKMADDLHLSVQTVSRAYD 216596000244 ectoine/hydroxyectoine ABC transporter, ATP-binding protein; Region: ectoine_ehuA; TIGR03005 216596000245 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 216596000246 Walker A/P-loop; other site 216596000247 ATP binding site [chemical binding]; other site 216596000248 Q-loop/lid; other site 216596000249 ABC transporter signature motif; other site 216596000250 Walker B; other site 216596000251 D-loop; other site 216596000252 H-loop/switch region; other site 216596000253 Pfam match to entry PF00005.11 ABC_tran, score 217.3, E-value 2.9e-62 216596000254 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 216596000255 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 216596000256 substrate binding pocket [chemical binding]; other site 216596000257 membrane-bound complex binding site; other site 216596000258 hinge residues; other site 216596000259 Pfam match to entry PF00497.8 SBP_bac_3, score 189.0, E-value 9.8e-54 216596000260 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 216596000261 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596000262 dimer interface [polypeptide binding]; other site 216596000263 conserved gate region; other site 216596000264 putative PBP binding loops; other site 216596000265 ABC-ATPase subunit interface; other site 216596000266 Pfam match to entry PF00528.10 BPD_transp_1, score 109.1, E-value 1e-29 216596000267 3 probable transmembrane helices predicted at aa 18-40, 69-91 and 183-205 216596000268 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 216596000269 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596000270 dimer interface [polypeptide binding]; other site 216596000271 conserved gate region; other site 216596000272 putative PBP binding loops; other site 216596000273 ABC-ATPase subunit interface; other site 216596000274 Pfam match to entry PF00528.10 BPD_transp_1, score 109.7, E-value 7.1e-30 216596000275 5 probable transmembrane helices predicted at aa 20-42, 55-77, 81-103, 133-155 and 185-207 216596000276 Predicted helix-turn-helix motif with score 1124.000, SD 3.02 at aa 116-137, sequence RGQWEAAKATNLSTRQAWIHVI 216596000277 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 216596000278 Pfam match to entry PF01177.8 Asp_Glu_race, score 104.4, E-value 2.8e-28 216596000279 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 216596000280 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 216596000281 tetramer interface [polypeptide binding]; other site 216596000282 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596000283 catalytic residue [active] 216596000284 Pfam match to entry PF00291.10 PALP, score 220.7,E-value 2.7e-63 216596000285 ectoine utilization protein EutC; Validated; Region: PRK08291 216596000286 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 216596000287 Pfam match to entry PF02423.5 OCD_Mu_crystall, score 442.1, E-value 6e-130 216596000288 ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993 216596000289 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 216596000290 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 216596000291 active site 216596000292 Pfam match to entry PF00557.9 Peptidase_M24, score 12.6, E-value 7.3e-08 216596000293 ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994 216596000294 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252 216596000295 putative active site [active] 216596000296 Zn binding site [ion binding]; other site 216596000297 Pfam match to entry PF04952.4 AstE_AspA, score 389.2, E-value 5.1e-114 216596000298 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216596000299 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 216596000300 dimer interface [polypeptide binding]; other site 216596000301 putative CheW interface [polypeptide binding]; other site 216596000302 Pfam match to entry PF00015.9 MCPsignal, score 250.2, E-value 3.5e-72 216596000303 Pfam match to entry PF00672.10 HAMP, score 43.5,E-value 5.8e-10 216596000304 2 probable transmembrane helices predicted at aa 38-60 and 220-242 216596000305 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 216596000306 oligomeric interface; other site 216596000307 putative active site [active] 216596000308 homodimer interface [polypeptide binding]; other site 216596000309 Pfam match to entry PF01850.8 PIN, score 90.6,E-value 4.1e-24 216596000310 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008 216596000311 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 216596000312 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 216596000313 Pfam match to entry PF07164.1 HAP3, score 328.7,E-value 8.1e-96 216596000314 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521 216596000315 Pfam match to entry PF06429.1 DUF1078, score 51.3, E-value 2.7e-12 216596000316 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 216596000317 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 216596000318 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 216596000319 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 216596000320 Pfam match to entry PF06429.1 DUF1078, score 69.2, E-value 1.1e-17 216596000321 Pfam match to entry PF07559.1 FlaE, score 40.8,E-value 4e-09 216596000322 Pfam match to entry PF00460.8 Flg_bb_rod, score 56.4, E-value 8e-14 216596000323 EF-hand domain pair; Region: EF_hand_5; pfam13499 216596000324 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 216596000325 Ca2+ binding site [ion binding]; other site 216596000326 EF-hand domain pair; Region: EF_hand_5; pfam13499 216596000327 Pfam match to entry PF00036.15 efhand, score 14.9, E-value 0.24 216596000328 Pfam match to entry PF00036.15 efhand, score 13.7, E-value 0.35 216596000329 Pfam match to entry PF00036.15 efhand, score 21.3, E-value 0.0029 216596000330 Pfam match to entry PF00036.15 efhand, score 7.5,E-value 1.8 216596000331 Pfam match to entry PF00036.15 efhand, score 3.3,E-value 5.4 216596000332 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216596000333 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216596000334 Pfam match to entry PF00440.8 TetR_N, score 61.1,E-value 3.1e-15 216596000335 Predicted helix-turn-helix motif with score 1631.000, SD 4.74 at aa 45-66, sequence STTAIVASEAGVSKQTLYKLFQ 216596000336 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 216596000337 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 216596000338 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 216596000339 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 216596000340 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 216596000341 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 216596000342 Pfam match to entry PF06748.1 DUF1217, score 174.9, E-value 1.7e-49 216596000343 Pfam match to entry PF06748.1 DUF1217, score 47.6, E-value 4.2e-13 216596000344 Pfam match to entry PF06748.1 DUF1217, score 233.5, E-value 3.9e-67 216596000345 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 216596000346 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216596000347 putative active site [active] 216596000348 heme pocket [chemical binding]; other site 216596000349 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216596000350 putative active site [active] 216596000351 heme pocket [chemical binding]; other site 216596000352 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216596000353 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 216596000354 dimer interface [polypeptide binding]; other site 216596000355 putative CheW interface [polypeptide binding]; other site 216596000356 Pfam match to entry PF00785.11 PAC, score 44.1,E-value 4.1e-10 216596000357 Pfam match to entry PF00785.11 PAC, score 28.9,E-value 1.5e-05 216596000358 Pfam match to entry PF00015.9 MCPsignal, score 298.2, E-value 1.3e-86 216596000359 enoyl-CoA hydratase; Provisional; Region: PRK05980 216596000360 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216596000361 substrate binding site [chemical binding]; other site 216596000362 oxyanion hole (OAH) forming residues; other site 216596000363 trimer interface [polypeptide binding]; other site 216596000364 Pfam match to entry PF00378.8 ECH, score 188.8,E-value 1.1e-53 216596000365 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216596000366 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216596000367 Pfam match to entry PF00440.8 TetR_N, score 72.7,E-value 9.6e-19 216596000368 Predicted helix-turn-helix motif with score 1631.000, SD 4.74 at aa 28-49, sequence VSVDAVAEEAGVTKRTLYYHFA 216596000369 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 216596000370 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 216596000371 substrate binding pocket [chemical binding]; other site 216596000372 membrane-bound complex binding site; other site 216596000373 hinge residues; other site 216596000374 Pfam match to entry PF00497.8 SBP_bac_3, score 173.2, E-value 5.5e-49 216596000375 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596000376 dimer interface [polypeptide binding]; other site 216596000377 conserved gate region; other site 216596000378 putative PBP binding loops; other site 216596000379 ABC-ATPase subunit interface; other site 216596000380 Pfam match to entry PF00528.10 BPD_transp_1, score 55.8, E-value 1.2e-13 216596000381 4 probable transmembrane helices predicted at aa 21-43, 58-80, 92-114 and 190-212 216596000382 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596000383 putative PBP binding loops; other site 216596000384 dimer interface [polypeptide binding]; other site 216596000385 ABC-ATPase subunit interface; other site 216596000386 4 probable transmembrane helices predicted at aa 9-31, 36-55, 62-84 and 187-204 216596000387 Pfam match to entry PF00528.10 BPD_transp_1, score 81.5, E-value 2.1e-21 216596000388 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 216596000389 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216596000390 Walker A/P-loop; other site 216596000391 ATP binding site [chemical binding]; other site 216596000392 Q-loop/lid; other site 216596000393 ABC transporter signature motif; other site 216596000394 Walker B; other site 216596000395 D-loop; other site 216596000396 H-loop/switch region; other site 216596000397 Pfam match to entry PF00005.11 ABC_tran, score 209.9, E-value 4.9e-60 216596000398 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 216596000399 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 216596000400 oligomeric interface; other site 216596000401 putative active site [active] 216596000402 homodimer interface [polypeptide binding]; other site 216596000403 Pfam match to entry PF01850.8 PIN, score 94.9,E-value 2e-25 216596000404 Transcriptional regulators [Transcription]; Region: FadR; COG2186 216596000405 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596000406 DNA-binding site [nucleotide binding]; DNA binding site 216596000407 FCD domain; Region: FCD; pfam07729 216596000408 Pfam match to entry PF00392.9 GntR, score 76.8,E-value 5.8e-20 216596000409 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 216596000410 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 216596000411 substrate binding pocket [chemical binding]; other site 216596000412 membrane-bound complex binding site; other site 216596000413 hinge residues; other site 216596000414 Pfam match to entry PF00497.8 SBP_bac_3, score 181.0, E-value 2.5e-51 216596000415 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596000416 dimer interface [polypeptide binding]; other site 216596000417 conserved gate region; other site 216596000418 putative PBP binding loops; other site 216596000419 ABC-ATPase subunit interface; other site 216596000420 Pfam match to entry PF00528.10 BPD_transp_1, score 69.4, E-value 9.3e-18 216596000421 3 probable transmembrane helices predicted at aa 20-42, 63-85 and 195-217 216596000422 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596000423 dimer interface [polypeptide binding]; other site 216596000424 conserved gate region; other site 216596000425 putative PBP binding loops; other site 216596000426 ABC-ATPase subunit interface; other site 216596000427 Pfam match to entry PF00528.10 BPD_transp_1, score 55.5, E-value 1.4e-13 216596000428 5 probable transmembrane helices predicted at aa 20-42, 55-77, 83-105, 142-164 and 179-201 216596000429 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 216596000430 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216596000431 Walker A/P-loop; other site 216596000432 ATP binding site [chemical binding]; other site 216596000433 Q-loop/lid; other site 216596000434 ABC transporter signature motif; other site 216596000435 Walker B; other site 216596000436 D-loop; other site 216596000437 H-loop/switch region; other site 216596000438 Pfam match to entry PF00005.11 ABC_tran, score 240.7, E-value 2.6e-69 216596000439 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 216596000440 Pfam match to entry PF05016.3 Plasmid_stabil, score 41.4, E-value 2.7e-09 216596000441 Uncharacterized conserved protein [Function unknown]; Region: COG5654 216596000442 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 216596000443 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 216596000444 PspA/IM30 family; Region: PspA_IM30; pfam04012 216596000445 Pfam match to entry PF04012.2 PspA_IM30, score 129.4, E-value 8.2e-36 216596000446 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; pfam09938 216596000447 Ion channel; Region: Ion_trans_2; pfam07885 216596000448 TrkA-N domain; Region: TrkA_N; pfam02254 216596000449 2 probable transmembrane helices predicted at aa 20-42 and 78-100 216596000450 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 216596000451 Predicted membrane protein [Function unknown]; Region: COG3766 216596000452 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 216596000453 Pfam match to entry PF03994.2 DUF350, score 52.5,E-value 1.2e-12 216596000454 4 probable transmembrane helices predicted at aa 10-32, 44-66, 76-98 and 110-132 216596000455 Pfam match to entry PF03994.2 DUF350, score 34.5,E-value 3.2e-07 216596000456 Protein of unknown function (DUF1190); Region: DUF1190; pfam06693 216596000457 2 probable transmembrane helices predicted at aa 12-29 and 101-123 216596000458 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 216596000459 Pfam match to entry PF03738.3 GSP_synth, score 623.1, E-value 2e-184 216596000460 Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form...; Region: 1,2-HQD; cd03461 216596000461 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 216596000462 dimer interface [polypeptide binding]; other site 216596000463 active site 216596000464 Pfam match to entry PF00775.10 Dioxygenase_C, score 252.0, E-value 1e-72 216596000465 Pfam match to entry PF04444.3 Dioxygenase_N, score 101.7, E-value 1.8e-27 216596000466 FAD binding domain; Region: FAD_binding_3; pfam01494 216596000467 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 216596000468 Pfam match to entry PF01360.9 Monooxygenase, score 211.2, E-value 2e-60 216596000469 Pfam match to entry PF01494.7 FAD_binding_3, score 128.8, E-value 1.2e-35 216596000470 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 216596000471 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 216596000472 TM-ABC transporter signature motif; other site 216596000473 9 probable transmembrane helices predicted at aa 21-43, 47-69, 76-93, 97-116,121-143, 182-204, 234-253, 268-297 and 304-323 216596000474 Pfam match to entry PF02653.5 BPD_transp_2, score 72.7, E-value 1e-18 216596000475 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 216596000476 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596000477 TM-ABC transporter signature motif; other site 216596000478 8 probable transmembrane helices predicted at aa 6-28, 41-58, 62-84, 91-110,137-159, 188-208, 228-250 and 263-282 216596000479 Pfam match to entry PF02653.5 BPD_transp_2, score 64.2, E-value 3.5e-16 216596000480 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 216596000481 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 216596000482 Walker A/P-loop; other site 216596000483 ATP binding site [chemical binding]; other site 216596000484 Q-loop/lid; other site 216596000485 ABC transporter signature motif; other site 216596000486 Walker B; other site 216596000487 D-loop; other site 216596000488 H-loop/switch region; other site 216596000489 Pfam match to entry PF00005.11 ABC_tran, score 133.2, E-value 6.1e-37 216596000490 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 216596000491 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 216596000492 Walker A/P-loop; other site 216596000493 ATP binding site [chemical binding]; other site 216596000494 Q-loop/lid; other site 216596000495 ABC transporter signature motif; other site 216596000496 Walker B; other site 216596000497 D-loop; other site 216596000498 H-loop/switch region; other site 216596000499 Pfam match to entry PF00005.11 ABC_tran, score 139.0, E-value 1.1e-38 216596000500 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 216596000501 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_4; cd06337 216596000502 putative ligand binding site [chemical binding]; other site 216596000503 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 216596000504 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 216596000505 active site 216596000506 dimer interface [polypeptide binding]; other site 216596000507 metal binding site [ion binding]; metal-binding site 216596000508 Pfam match to entry PF00465.7 Fe-ADH, score 67.7,E-value 2.9e-19 216596000509 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 216596000510 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 216596000511 active site 216596000512 Pfam match to entry PF00775.10 Dioxygenase_C, score 199.8, E-value 5.4e-57 216596000513 Pfam match to entry PF04444.3 Dioxygenase_N, score 73.6, E-value 5.1e-19 216596000514 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596000515 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596000516 LysR substrate binding domain; Region: LysR_substrate; pfam03466 216596000517 dimerization interface [polypeptide binding]; other site 216596000518 Pfam match to entry PF03466.5 LysR_substrate, score 115.4, E-value 1.3e-31 216596000519 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596000520 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596000521 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 216596000522 putative effector binding pocket; other site 216596000523 putative dimerization interface [polypeptide binding]; other site 216596000524 Pfam match to entry PF00126.10 HTH_1, score 71.9,E-value 1.7e-18 216596000525 Predicted helix-turn-helix motif with score 1313.000, SD 3.66 at aa 21-42, sequence RSFRKAADHLEVTASALSHSMK 216596000526 Pfam match to entry PF03466.5 LysR_substrate, score 142.8, E-value 7.9e-40 216596000527 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 216596000528 extended (e) SDRs; Region: SDR_e; cd08946 216596000529 NAD(P) binding site [chemical binding]; other site 216596000530 active site 216596000531 substrate binding site [chemical binding]; other site 216596000532 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 216596000533 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 216596000534 active site 216596000535 catalytic tetrad [active] 216596000536 Pfam match to entry PF00248.9 Aldo_ket_red, score 256.4, E-value 4.7e-74 216596000537 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 216596000538 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 216596000539 active site 216596000540 catalytic tetrad [active] 216596000541 Pfam match to entry PF00248.9 Aldo_ket_red, score 280.4, E-value 2.9e-81 216596000542 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 216596000543 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 216596000544 active site 216596000545 catalytic tetrad [active] 216596000546 Pfam match to entry PF00248.9 Aldo_ket_red, score 230.8, E-value 2.4e-66 216596000547 Similar to codons 165 to 370 of Streptomyces avermitilis putative transport protein SWALL:Q827M4 (EMBL:AP005048) (403 aa); similarity:fasta; SWALL:Q827M4 (EMBL:AP005048); Streptomyces avermitilis; putative transport protein; length 403 aa; id=35.02; ungapped id=35.93; E()=2.1e-13; 197 aa overlap; query 12-204 aa; subject 171-366 aa; putative transport protein, pseudogene 216596000548 Pfam match to entry PF07690.1 MFS_1, score 33.8,E-value 2.1e-09 216596000549 3 probable transmembrane helices predicted at aa 10-30, 37-59 and 63-85 216596000550 N-terminus to codon 195 is similar to the N-terminus to codon 195 Methanosarcina mazei putative ketoreductase SWALL:Q8PS57 (EMBL:AE013581) (236 aa); similarity:fasta; SWALL:Q8PS57 (EMBL:AE013581); Methanosarcina mazei; putative ketoreductase; length 236 aa; id=40.1; ungapped id=40.95; E()=2.1e-18; 192 aa overlap; query 3-193 aa; subject 2-190 aa; putative ketoreductase, pseudogene 216596000551 Pfam match to entry PF00106.11 adh_short, score 161.8, E-value 1.4e-45 216596000552 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 216596000553 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 216596000554 Pfam match to entry PF01547.11 SBP_bac_1, score 72.8, E-value 9.3e-19 216596000555 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 216596000556 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596000557 putative PBP binding loops; other site 216596000558 ABC-ATPase subunit interface; other site 216596000559 7 probable transmembrane helices predicted at aa 36-58, 95-117, 130-152,157-179, 186-208, 232-254 and 289-311 216596000560 Pfam match to entry PF00528.10 BPD_transp_1, score 40.2, E-value 5.8e-09 216596000561 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216596000562 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596000563 dimer interface [polypeptide binding]; other site 216596000564 conserved gate region; other site 216596000565 putative PBP binding loops; other site 216596000566 ABC-ATPase subunit interface; other site 216596000567 6 probable transmembrane helices predicted at aa 7-29, 74-96, 103-125, 135-154,193-215 and 235-257 216596000568 Pfam match to entry PF00528.10 BPD_transp_1, score 68.0, E-value 2.6e-17 216596000569 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 216596000570 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 216596000571 Transcriptional regulators [Transcription]; Region: PurR; COG1609 216596000572 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216596000573 DNA binding site [nucleotide binding] 216596000574 domain linker motif; other site 216596000575 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 216596000576 dimerization interface [polypeptide binding]; other site 216596000577 ligand binding site [chemical binding]; other site 216596000578 Predicted helix-turn-helix motif with score 1479.000, SD 4.22 at aa 61-82, sequence ATIIDVARVADVAVGTVSRYLN 216596000579 Pfam match to entry PF00532.8 Peripla_BP_1, score 59.6, E-value 8.6e-15 216596000580 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 216596000581 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 216596000582 Walker A/P-loop; other site 216596000583 ATP binding site [chemical binding]; other site 216596000584 Q-loop/lid; other site 216596000585 ABC transporter signature motif; other site 216596000586 Walker B; other site 216596000587 D-loop; other site 216596000588 H-loop/switch region; other site 216596000589 TOBE domain; Region: TOBE_2; pfam08402 216596000590 Pfam match to entry PF00005.11 ABC_tran, score 213.6, E-value 3.8e-61 216596000591 Pfam match to entry PF03459.4 TOBE, score 26.5,E-value 1.4e-06 216596000592 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 216596000593 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 216596000594 active site 216596000595 catalytic tetrad [active] 216596000596 Pfam match to entry PF00248.9 Aldo_ket_red, score 148.1, E-value 2e-41 216596000597 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 216596000598 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 216596000599 putative NAD(P) binding site [chemical binding]; other site 216596000600 putative active site [active] 216596000601 Pfam match to entry PF00106.11 adh_short, score 152.4, E-value 9.9e-43 216596000602 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 216596000603 classical (c) SDRs; Region: SDR_c; cd05233 216596000604 NAD(P) binding site [chemical binding]; other site 216596000605 active site 216596000606 Pfam match to entry PF00106.11 adh_short, score 250.0, E-value 4.2e-72 216596000607 Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044 216596000608 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 216596000609 active site 216596000610 Pfam match to entry PF01979.7 Amidohydro_1, score 48.8, E-value 1.6e-11 216596000611 hypothetical protein; Provisional; Region: PRK06154 216596000612 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 216596000613 PYR/PP interface [polypeptide binding]; other site 216596000614 dimer interface [polypeptide binding]; other site 216596000615 TPP binding site [chemical binding]; other site 216596000616 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 216596000617 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 216596000618 TPP-binding site; other site 216596000619 dimer interface [polypeptide binding]; other site 216596000620 Pfam match to entry PF00205.10 TPP_enzyme_M, score 98.2, E-value 2.1e-26 216596000621 Pfam match to entry PF02776.6 TPP_enzyme_N, score 40.2, E-value 2.2e-11 216596000622 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 216596000623 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 216596000624 active site 216596000625 catalytic site [active] 216596000626 tetramer interface [polypeptide binding]; other site 216596000627 Pfam match to entry PF01522.9 Polysacc_deac_1, score 13.3, E-value 2.3e-05 216596000628 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 216596000629 extended (e) SDRs; Region: SDR_e; cd08946 216596000630 NAD(P) binding site [chemical binding]; other site 216596000631 active site 216596000632 substrate binding site [chemical binding]; other site 216596000633 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 216596000634 classical (c) SDRs; Region: SDR_c; cd05233 216596000635 NAD(P) binding site [chemical binding]; other site 216596000636 active site 216596000637 Pfam match to entry PF00106.11 adh_short, score 217.3, E-value 3e-62 216596000638 dihydropyrimidinase; Provisional; Region: PRK13404 216596000639 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 216596000640 tetramer interface [polypeptide binding]; other site 216596000641 active site 216596000642 Pfam match to entry PF01979.7 Amidohydro_1, score 31.7, E-value 2.2e-06 216596000643 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596000644 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216596000645 putative substrate translocation pore; other site 216596000646 12 probable transmembrane helices predicted at aa 21-43, 58-80, 87-109, 114-136,143-165, 175-197, 218-240, 260-282, 291-313, 317-339,352-371 and 381-403 216596000647 Pfam match to entry PF07690.1 MFS_1, score 77.8,E-value 2.9e-20 216596000648 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 216596000649 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596000650 Walker A/P-loop; other site 216596000651 ATP binding site [chemical binding]; other site 216596000652 Q-loop/lid; other site 216596000653 ABC transporter signature motif; other site 216596000654 Walker B; other site 216596000655 D-loop; other site 216596000656 H-loop/switch region; other site 216596000657 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 216596000658 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596000659 Walker A/P-loop; other site 216596000660 ATP binding site [chemical binding]; other site 216596000661 Q-loop/lid; other site 216596000662 ABC transporter signature motif; other site 216596000663 Walker B; other site 216596000664 D-loop; other site 216596000665 H-loop/switch region; other site 216596000666 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216596000667 Pfam match to entry PF00005.11 ABC_tran, score 196.6, E-value 5e-56 216596000668 Pfam match to entry PF00005.11 ABC_tran, score 204.9, E-value 1.6e-58 216596000669 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 216596000670 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596000671 dimer interface [polypeptide binding]; other site 216596000672 conserved gate region; other site 216596000673 ABC-ATPase subunit interface; other site 216596000674 Pfam match to entry PF00528.10 BPD_transp_1, score 119.9, E-value 5.8e-33 216596000675 6 probable transmembrane helices predicted at aa 32-54, 99-121, 128-150,160-182, 220-239 and 259-281 216596000676 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 216596000677 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596000678 dimer interface [polypeptide binding]; other site 216596000679 conserved gate region; other site 216596000680 putative PBP binding loops; other site 216596000681 ABC-ATPase subunit interface; other site 216596000682 Pfam match to entry PF00528.10 BPD_transp_1, score 118.8, E-value 1.3e-32 216596000683 6 probable transmembrane helices predicted at aa 13-35, 124-146, 159-181,196-218, 265-287 and 307-329 216596000684 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 216596000685 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 216596000686 Pfam match to entry PF00496.9 SBP_bac_5, score 35.9, E-value 1.2e-07 216596000687 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 216596000688 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 216596000689 conserved cys residue [active] 216596000690 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216596000691 Pfam match to entry PF00165.8 HTH_AraC, score 27.6, E-value 3.6e-05 216596000692 Pfam match to entry PF00165.8 HTH_AraC, score 21.0, E-value 0.0035 216596000693 Pfam match to entry PF01965.10 DJ-1_PfpI, score 31.4, E-value 2.7e-06 216596000694 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 216596000695 oligomeric interface; other site 216596000696 putative active site [active] 216596000697 homodimer interface [polypeptide binding]; other site 216596000698 Pfam match to entry PF01850.8 PIN, score 68.6,E-value 1.7e-17 216596000699 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 216596000700 Putative cyclase; Region: Cyclase; pfam04199 216596000701 Pfam match to entry PF04199.2 Cyclase, score 10.8, E-value 6.5e-06 216596000702 hypothetical protein; Provisional; Region: PRK06102 216596000703 Amidase; Region: Amidase; cl11426 216596000704 Pfam match to entry PF01425.8 Amidase, score 257.3, E-value 2.6e-74 216596000705 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 216596000706 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 216596000707 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 216596000708 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 216596000709 Pfam match to entry PF07683.1 CobW_C, score 92.6,E-value 1e-24 216596000710 Pfam match to entry PF02492.7 cobW, score 180.8,E-value 2.7e-51 216596000711 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 216596000712 active site 216596000713 catalytic site [active] 216596000714 Zn binding site [ion binding]; other site 216596000715 tetramer interface [polypeptide binding]; other site 216596000716 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 216596000717 Pfam match to entry PF01522.9 Polysacc_deac_1, score 104.2, E-value 3.3e-28 216596000718 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 216596000719 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216596000720 Walker A/P-loop; other site 216596000721 ATP binding site [chemical binding]; other site 216596000722 Q-loop/lid; other site 216596000723 ABC transporter signature motif; other site 216596000724 Walker B; other site 216596000725 D-loop; other site 216596000726 H-loop/switch region; other site 216596000727 Pfam match to entry PF00005.11 ABC_tran, score 235.4, E-value 1e-67 216596000728 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 216596000729 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 216596000730 classical (c) SDRs; Region: SDR_c; cd05233 216596000731 aldose dehydrogenase; Validated; Region: PRK06398 216596000732 NAD(P) binding site [chemical binding]; other site 216596000733 active site 216596000734 Pfam match to entry PF00106.11 adh_short, score 283.0, E-value 4.7e-82 216596000735 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 216596000736 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216596000737 NAD(P) binding site [chemical binding]; other site 216596000738 active site 216596000739 Pfam match to entry PF00106.11 adh_short, score 263.8, E-value 3e-76 216596000740 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 216596000741 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596000742 putative PBP binding loops; other site 216596000743 dimer interface [polypeptide binding]; other site 216596000744 ABC-ATPase subunit interface; other site 216596000745 Pfam match to entry PF00528.10 BPD_transp_1, score 39.5, E-value 9.7e-09 216596000746 6 probable transmembrane helices predicted at aa 9-31, 73-95, 108-130, 140-162,190-209 and 243-265 216596000747 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 216596000748 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596000749 dimer interface [polypeptide binding]; other site 216596000750 conserved gate region; other site 216596000751 putative PBP binding loops; other site 216596000752 ABC-ATPase subunit interface; other site 216596000753 Pfam match to entry PF00528.10 BPD_transp_1, score 52.7, E-value 1.1e-12 216596000754 6 probable transmembrane helices predicted at aa 25-47, 87-109, 116-138,173-195, 216-238 and 268-290 216596000755 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 216596000756 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216596000757 Walker A/P-loop; other site 216596000758 ATP binding site [chemical binding]; other site 216596000759 Q-loop/lid; other site 216596000760 ABC transporter signature motif; other site 216596000761 Walker B; other site 216596000762 D-loop; other site 216596000763 H-loop/switch region; other site 216596000764 Pfam match to entry PF00005.11 ABC_tran, score 174.7, E-value 1.9e-49 216596000765 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596000766 DNA-binding site [nucleotide binding]; DNA binding site 216596000767 Transcriptional regulators [Transcription]; Region: GntR; COG1802 216596000768 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 216596000769 DNA-binding site [nucleotide binding]; DNA binding site 216596000770 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 216596000771 Pfam match to entry PF00392.9 GntR, score 57.5,E-value 3.7e-14 216596000772 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 216596000773 Pfam match to entry PF02626.5 AHS2, score 251.6,E-value 1.4e-72 216596000774 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 216596000775 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 216596000776 Pfam match to entry PF02682.5 AHS1, score 0.7,E-value 6.2e-08 216596000777 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 216596000778 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 216596000779 ATP-grasp domain; Region: ATP-grasp_4; cl17255 216596000780 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 216596000781 Pfam match to entry PF02785.5 Biotin_carb_C, score 168.7, E-value 1.2e-47 216596000782 Pfam match to entry PF02786.4 CPSase_L_D2, score 338.1, E-value 1.3e-98 216596000783 Pfam match to entry PF00289.9 CPSase_L_chain, score 150.5, E-value 3.7e-42 216596000784 Similar to codons 105 to the C-terminus of Anabaena sp. biotin carboxyl carrier protein of acetyl-CoA carboxylase AccB SWALL:BCCP_ANASP (SWALL:Q06881) (181 aa), and to Pseudomonas aeruginosa probable biotin-requiring enzyme SWALL:Q9I625 (EMBL:AE004486) (82 aa); similarity:fasta; SWALL:BCCP_ANASP (SWALL:Q06881); Anabaena sp.; biotin carboxyl carrier protein of acetyl-coa carboxylase; accB; length 181 aa; id=42.66; ungapped id=42.66; E()=1.6e-06; 75 aa overlap; query 10-84 aa; subject 105-179 aa; similarity:fasta; SWALL:Q9I625 (EMBL:AE004486); Pseudomonas aeruginosa; probable biotin-requiring enzyme; length 82 aa; id=47.43; ungapped id=47.43; E()=2.5e-09; 78 aa overlap; query 6-83 aa; subject 1-78 aa; putative biotin carboxyl carrier protein,pseudogene 216596000785 Pfam match to entry PF00364.9 Biotin_lipoyl, score 58.0, E-value 2.6e-14 216596000786 hypothetical protein; Provisional; Region: PRK12569 216596000787 Pfam match to entry PF03746.4 LamB_YcsF, score 358.3, E-value 1e-104 216596000788 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596000789 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596000790 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 216596000791 putative substrate binding pocket [chemical binding]; other site 216596000792 dimerization interface [polypeptide binding]; other site 216596000793 Pfam match to entry PF00126.10 HTH_1, score 74.1,E-value 3.7e-19 216596000794 Predicted helix-turn-helix motif with score 1182.000, SD 3.21 at aa 59-80, sequence GQISYAAAQLSISQSAVTTAIK 216596000795 Pfam match to entry PF03466.5 LysR_substrate, score 145.0, E-value 1.6e-40 216596000796 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 216596000797 Phosphotransferase enzyme family; Region: APH; pfam01636 216596000798 active site 216596000799 ATP binding site [chemical binding]; other site 216596000800 substrate binding site [chemical binding]; other site 216596000801 dimer interface [polypeptide binding]; other site 216596000802 Pfam match to entry PF01633.7 Choline_kinase, score -81.6, E-value 1.1e-05 216596000803 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 216596000804 Phosphotransferase enzyme family; Region: APH; pfam01636 216596000805 active site 216596000806 ATP binding site [chemical binding]; other site 216596000807 substrate binding site [chemical binding]; other site 216596000808 allantoate amidohydrolase; Reviewed; Region: PRK09290 216596000809 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 216596000810 active site 216596000811 metal binding site [ion binding]; metal-binding site 216596000812 dimer interface [polypeptide binding]; other site 216596000813 Pfam match to entry PF07687.1 M20_dimer, score 17.9, E-value 0.0058 216596000814 Pfam match to entry PF01546.13 Peptidase_M20, score 20.9, E-value 0.00032 216596000815 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 216596000816 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 216596000817 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 216596000818 Pfam match to entry PF00455.10 DeoR, score 211.9,E-value 1.2e-60 216596000819 Predicted helix-turn-helix motif with score 1848.000, SD 5.48 at aa 57-78, sequence VTVKELAAEFSVSPETVRRDLK 216596000820 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 216596000821 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596000822 Walker A/P-loop; other site 216596000823 ATP binding site [chemical binding]; other site 216596000824 Q-loop/lid; other site 216596000825 ABC transporter signature motif; other site 216596000826 Walker B; other site 216596000827 D-loop; other site 216596000828 H-loop/switch region; other site 216596000829 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596000830 Walker A/P-loop; other site 216596000831 ATP binding site [chemical binding]; other site 216596000832 Q-loop/lid; other site 216596000833 ABC transporter signature motif; other site 216596000834 Walker B; other site 216596000835 D-loop; other site 216596000836 H-loop/switch region; other site 216596000837 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216596000838 Pfam match to entry PF00005.11 ABC_tran, score 188.9, E-value 1e-53 216596000839 Pfam match to entry PF00005.11 ABC_tran, score 115.0, E-value 1.8e-31 216596000840 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 216596000841 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596000842 dimer interface [polypeptide binding]; other site 216596000843 conserved gate region; other site 216596000844 putative PBP binding loops; other site 216596000845 ABC-ATPase subunit interface; other site 216596000846 Pfam match to entry PF00528.10 BPD_transp_1, score 150.9, E-value 2.7e-42 216596000847 6 probable transmembrane helices predicted at aa 35-57, 110-132, 153-175,212-231, 238-257 and 272-294 216596000848 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 216596000849 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596000850 dimer interface [polypeptide binding]; other site 216596000851 conserved gate region; other site 216596000852 putative PBP binding loops; other site 216596000853 ABC-ATPase subunit interface; other site 216596000854 Pfam match to entry PF00528.10 BPD_transp_1, score 136.7, E-value 5.1e-38 216596000855 7 probable transmembrane helices predicted at aa 10-32, 122-144, 154-176,183-205, 209-231, 252-274 and 294-316 216596000856 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 216596000857 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 216596000858 Pfam match to entry PF00496.9 SBP_bac_5, score 73.5, E-value 5.6e-19 216596000859 Similar to codons 75 to 65 of Rhizobium loti mll1719 protein SWALL:Q98JY9 (EMBL:AP002998) (135 aa); similarity:fasta; SWALL:Q98JY9 (EMBL:AP002998); Rhizobium loti; mll1719 protein; length 135 aa; id=62.29; ungapped id=62.29; E()=2.5e-12; 61 aa overlap; query 1-61 aa; subject 75-135 aa; conserved hypothetical protein, pseudogene 216596000860 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 216596000861 3 probable transmembrane helices predicted at aa 5-27, 37-59 and 66-83 216596000862 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 216596000863 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596000864 putative substrate translocation pore; other site 216596000865 Pfam match to entry PF00083.10 Sugar_tr, score -45.7, E-value 1.1e-05 216596000866 12 probable transmembrane helices predicted at aa 56-78, 88-110, 123-142,147-169, 181-203, 213-235, 255-277, 287-309, 322-341,346-368, 381-403 and 413-435 216596000867 Pfam match to entry PF07690.1 MFS_1, score 201.1,E-value 2.1e-57 216596000868 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596000869 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596000870 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_10; cd08480 216596000871 putative effector binding pocket; other site 216596000872 putative dimerization interface [polypeptide binding]; other site 216596000873 Pfam match to entry PF00126.10 HTH_1, score 63.6,E-value 5.5e-16 216596000874 Predicted helix-turn-helix motif with score 1521.000, SD 4.37 at aa 11-32, sequence QSFSAAGRRLKMSPSAVSKLVT 216596000875 Pfam match to entry PF03466.5 LysR_substrate, score 143.0, E-value 6.7e-40 216596000876 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 216596000877 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596000878 dimer interface [polypeptide binding]; other site 216596000879 conserved gate region; other site 216596000880 putative PBP binding loops; other site 216596000881 ABC-ATPase subunit interface; other site 216596000882 Pfam match to entry PF00528.10 BPD_transp_1, score 48.0, E-value 2.6e-11 216596000883 6 probable transmembrane helices predicted at aa 13-35, 70-92, 104-126,130-152, 191-213 and 233-255 216596000884 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 216596000885 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596000886 dimer interface [polypeptide binding]; other site 216596000887 conserved gate region; other site 216596000888 putative PBP binding loops; other site 216596000889 ABC-ATPase subunit interface; other site 216596000890 Pfam match to entry PF00528.10 BPD_transp_1, score 27.6, E-value 3.7e-05 216596000891 6 probable transmembrane helices predicted at aa 12-34, 70-92, 104-126,149-171, 204-226 and 254-276 216596000892 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 216596000893 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216596000894 Walker A/P-loop; other site 216596000895 ATP binding site [chemical binding]; other site 216596000896 Q-loop/lid; other site 216596000897 ABC transporter signature motif; other site 216596000898 Walker B; other site 216596000899 D-loop; other site 216596000900 H-loop/switch region; other site 216596000901 TOBE domain; Region: TOBE_2; pfam08402 216596000902 Pfam match to entry PF00005.11 ABC_tran, score 252.8, E-value 5.8e-73 216596000903 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 216596000904 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 216596000905 Pfam match to entry PF01547.11 SBP_bac_1, score 35.7, E-value 1.4e-07 216596000906 oxidase reductase; Provisional; Region: PTZ00273 216596000907 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 216596000908 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 216596000909 Pfam match to entry PF03171.7 2OG-FeII_Oxy, score 76.5, E-value 7e-20 216596000910 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 216596000911 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 216596000912 substrate binding site [chemical binding]; other site 216596000913 ATP binding site [chemical binding]; other site 216596000914 Pfam match to entry PF00294.10 PfkB, score 141.8,E-value 1.5e-39 216596000915 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 216596000916 Pfam match to entry PF04227.2 Indigoidine_A, score 593.2, E-value 2e-175 216596000917 enoyl-CoA hydratase; Provisional; Region: PRK05995 216596000918 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216596000919 substrate binding site [chemical binding]; other site 216596000920 oxyanion hole (OAH) forming residues; other site 216596000921 trimer interface [polypeptide binding]; other site 216596000922 Pfam match to entry PF00378.8 ECH, score 122.8,E-value 8.3e-34 216596000923 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 216596000924 CoA binding domain; Region: CoA_binding_2; pfam13380 216596000925 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 216596000926 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 216596000927 Pfam match to entry PF02629.7 CoA_binding, score 59.4, E-value 9.5e-15 216596000928 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 216596000929 active site 216596000930 tetramer interface [polypeptide binding]; other site 216596000931 Pfam match to entry PF01156.8 IU_nuc_hydro, score 355.9, E-value 5.5e-104 216596000932 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 216596000933 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 216596000934 dimer interface [polypeptide binding]; other site 216596000935 PYR/PP interface [polypeptide binding]; other site 216596000936 TPP binding site [chemical binding]; other site 216596000937 substrate binding site [chemical binding]; other site 216596000938 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 216596000939 TPP-binding site [chemical binding]; other site 216596000940 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 216596000941 Pfam match to entry PF01558.6 POR, score -12.9,E-value 0.0001 216596000942 Pfam match to entry PF02775.6 TPP_enzyme_C, score 86.1, E-value 8.7e-23 216596000943 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 216596000944 FAD binding domain; Region: FAD_binding_4; pfam01565 216596000945 Pfam match to entry PF02913.7 FAD-oxidase_C, score 185.3, E-value 1.2e-52 216596000946 Pfam match to entry PF01565.10 FAD_binding_4, score 211.3, E-value 1.8e-60 216596000947 Transcriptional regulators [Transcription]; Region: FadR; COG2186 216596000948 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596000949 DNA-binding site [nucleotide binding]; DNA binding site 216596000950 FCD domain; Region: FCD; pfam07729 216596000951 Pfam match to entry PF00392.9 GntR, score 76.9,E-value 5.3e-20 216596000952 Predicted helix-turn-helix motif with score 1699.000, SD 4.97 at aa 37-58, sequence PTEEDLAKSFGISRPTVREALK 216596000953 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 216596000954 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 216596000955 NADP binding site [chemical binding]; other site 216596000956 dimer interface [polypeptide binding]; other site 216596000957 Pfam match to entry PF00107.11 ADH_zinc_N, score 128.0, E-value 2.2e-35 216596000958 Putative Aconitase X swivel domain. It is predicted by comparative genomic analysis. The proteins are mainly found in archaea and proteobacteria. They are distantly related to Aconitase family of proteins by sequence similarity and seconary structure...; Region: AcnX_swivel; cd01356 216596000959 substrate binding site [chemical binding]; other site 216596000960 Protein of unknown function (DUF521); Region: DUF521; pfam04412 216596000961 Putative Aconitase X catalytic domain; Region: AcnX; cd01355 216596000962 substrate binding site [chemical binding]; other site 216596000963 ligand binding site [chemical binding]; other site 216596000964 Pfam match to entry PF04412.2 DUF521, score 557.1, E-value 1.5e-164 216596000965 Pfam match to entry PF01989.6 DUF126, score 70.4,E-value 4.8e-18 216596000966 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596000967 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216596000968 putative substrate translocation pore; other site 216596000969 12 probable transmembrane helices predicted at aa 9-26, 41-63, 70-87, 91-113,133-155, 159-181, 194-216, 231-253, 265-287, 292-314,327-349 and 354-371 216596000970 Pfam match to entry PF07690.1 MFS_1, score 66.7,E-value 6.3e-17 216596000971 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 216596000972 FMN binding site [chemical binding]; other site 216596000973 dimer interface [polypeptide binding]; other site 216596000974 Pfam match to entry PF00881.10 Nitroreductase, score 14.3, E-value 4.3e-07 216596000975 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 216596000976 Pfam match to entry PF01593.9 Amino_oxidase, score 125.8, E-value 1e-34 216596000977 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 216596000978 Pfam match to entry PF00999.9 Na_H_Exchanger, score 144.4, E-value 2.5e-40 216596000979 12 probable transmembrane helices predicted at aa 4-21, 28-50, 54-76, 83-105,110-132, 144-166, 176-198, 219-241, 261-280, 300-322,342-364 and 371-393 216596000980 Transcriptional regulators [Transcription]; Region: PurR; COG1609 216596000981 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216596000982 DNA binding site [nucleotide binding] 216596000983 domain linker motif; other site 216596000984 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 216596000985 dimerization interface [polypeptide binding]; other site 216596000986 ligand binding site [chemical binding]; other site 216596000987 Pfam match to entry PF00532.8 Peripla_BP_1, score -39.0, E-value 0.033 216596000988 Predicted helix-turn-helix motif with score 1369.000, SD 3.85 at aa 34-55, sequence ATIYDLSMLSGASPSTVSAVLN 216596000989 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 216596000990 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 216596000991 ligand binding site [chemical binding]; other site 216596000992 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 216596000993 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 216596000994 Walker A/P-loop; other site 216596000995 ATP binding site [chemical binding]; other site 216596000996 Q-loop/lid; other site 216596000997 ABC transporter signature motif; other site 216596000998 Walker B; other site 216596000999 D-loop; other site 216596001000 H-loop/switch region; other site 216596001001 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 216596001002 Pfam match to entry PF00005.11 ABC_tran, score 170.1, E-value 4.8e-48 216596001003 Pfam match to entry PF00005.11 ABC_tran, score 103.9, E-value 4e-28 216596001004 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596001005 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216596001006 TM-ABC transporter signature motif; other site 216596001007 9 probable transmembrane helices predicted at aa 12-29, 39-61, 66-83, 87-109,116-138, 167-189, 210-232, 263-285 and 292-314 216596001008 Pfam match to entry PF02653.5 BPD_transp_2, score 159.9, E-value 5.5e-45 216596001009 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216596001010 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596001011 TM-ABC transporter signature motif; other site 216596001012 10 probable transmembrane helices predicted at aa 11-33, 37-59, 66-88, 103-125,132-154, 169-191, 220-242, 252-270, 275-297 and 302-321 216596001013 Pfam match to entry PF02653.5 BPD_transp_2, score 159.4, E-value 7.7e-45 216596001014 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 216596001015 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 216596001016 Metal-binding active site; metal-binding site 216596001017 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 216596001018 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 216596001019 intersubunit interface [polypeptide binding]; other site 216596001020 active site 216596001021 zinc binding site [ion binding]; other site 216596001022 Na+ binding site [ion binding]; other site 216596001023 Pfam match to entry PF01116.8 F_bP_aldolase, score 583.7, E-value 1.4e-172 216596001024 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 216596001025 Pfam match to entry PF01266.8 DAO, score 127.0,E-value 4.4e-35 216596001026 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 216596001027 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 216596001028 putative N- and C-terminal domain interface [polypeptide binding]; other site 216596001029 putative active site [active] 216596001030 MgATP binding site [chemical binding]; other site 216596001031 catalytic site [active] 216596001032 metal binding site [ion binding]; metal-binding site 216596001033 putative xylulose binding site [chemical binding]; other site 216596001034 Pfam match to entry PF02782.4 FGGY_C, score 61.8,E-value 1.9e-15 216596001035 Pfam match to entry PF00370.9 FGGY_N, score 220.6, E-value 2.9e-63 216596001036 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 216596001037 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 216596001038 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 216596001039 Pfam match to entry PF00455.10 DeoR, score 205.2,E-value 1.3e-58 216596001040 Predicted helix-turn-helix motif with score 1053.000, SD 2.77 at aa 41-62, sequence MRIEDLTDRFGISLMTAHRDVD 216596001041 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 216596001042 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 216596001043 ligand binding site [chemical binding]; other site 216596001044 dimerization interface [polypeptide binding]; other site 216596001045 Pfam match to entry PF00532.8 Peripla_BP_1, score 1.1, E-value 0.0002 216596001046 1 probable transmembrane helix predicted at aa 7-29 216596001047 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596001048 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216596001049 TM-ABC transporter signature motif; other site 216596001050 10 probable transmembrane helices predicted at aa 26-45, 55-77, 89-111, 116-138,145-167, 191-213, 243-265, 270-292, 299-321 and 326-343 216596001051 Pfam match to entry PF02653.5 BPD_transp_2, score 252.1, E-value 9.3e-73 216596001052 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 216596001053 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 216596001054 Walker A/P-loop; other site 216596001055 ATP binding site [chemical binding]; other site 216596001056 Q-loop/lid; other site 216596001057 ABC transporter signature motif; other site 216596001058 Walker B; other site 216596001059 D-loop; other site 216596001060 H-loop/switch region; other site 216596001061 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 216596001062 Pfam match to entry PF00005.11 ABC_tran, score 94.9, E-value 2e-25 216596001063 Pfam match to entry PF00005.11 ABC_tran, score 191.5, E-value 1.7e-54 216596001064 Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; pfam10054 216596001065 1 probable transmembrane helix predicted at aa 56-78 216596001066 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 216596001067 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 216596001068 putative N- and C-terminal domain interface [polypeptide binding]; other site 216596001069 putative active site [active] 216596001070 MgATP binding site [chemical binding]; other site 216596001071 catalytic site [active] 216596001072 metal binding site [ion binding]; metal-binding site 216596001073 putative xylulose binding site [chemical binding]; other site 216596001074 Pfam match to entry PF00370.9 FGGY_N, score 115.0, E-value 1.8e-31 216596001075 Pfam match to entry PF02782.4 FGGY_C, score 19.0,E-value 2e-09 216596001076 glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK13369 216596001077 Pfam match to entry PF01266.8 DAO, score 354.7,E-value 1.2e-103 216596001078 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 216596001079 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 216596001080 PCI domain; Region: PCI; cl02111 216596001081 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 216596001082 Predicted helix-turn-helix motif with score 1289.000, SD 3.58 at aa 21-42, sequence LTQSDVARRLGVPSVKAHRLIA 216596001083 Pfam match to entry PF04198.2 Sugar-bind, score 360.8, E-value 1.8e-105 216596001084 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 216596001085 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 216596001086 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 216596001087 Pfam match to entry PF00455.10 DeoR, score 160.1,E-value 4.8e-45 216596001088 Predicted helix-turn-helix motif with score 1058.000, SD 2.79 at aa 20-41, sequence VDLDDLADRFTVSKMTIHRDLD 216596001089 triosephosphate isomerase; Provisional; Region: PRK14565 216596001090 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 216596001091 substrate binding site [chemical binding]; other site 216596001092 dimer interface [polypeptide binding]; other site 216596001093 catalytic triad [active] 216596001094 Pfam match to entry PF00121.7 TIM, score 200.4,E-value 3.6e-57 216596001095 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 216596001096 Pfam match to entry PF02502.6 LacAB_rpiB, score 165.3, E-value 1.3e-46 216596001097 no significant database hits 216596001098 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 216596001099 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 216596001100 active site 216596001101 DNA binding site [nucleotide binding] 216596001102 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 216596001103 DNA binding site [nucleotide binding] 216596001104 Pfam match to entry PF01068.9 DNA_ligase_A_M, score 102.8, E-value 8.7e-28 216596001105 Pfam match to entry PF04679.4 DNA_ligase_A_C, score 13.1, E-value 0.0051 216596001106 YciI-like protein; Reviewed; Region: PRK12863 216596001107 Pfam match to entry PF03795.3 YCII, score 51.4,E-value 2.4e-12 216596001108 Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form...; Region: 1,2-HQD; cd03461 216596001109 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 216596001110 dimer interface [polypeptide binding]; other site 216596001111 active site 216596001112 Pfam match to entry PF00775.10 Dioxygenase_C, score 242.2, E-value 9.3e-70 216596001113 Pfam match to entry PF04444.3 Dioxygenase_N, score 103.4, E-value 5.7e-28 216596001114 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 216596001115 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 216596001116 active site 216596001117 dimer interface [polypeptide binding]; other site 216596001118 metal binding site [ion binding]; metal-binding site 216596001119 Pfam match to entry PF00465.7 Fe-ADH, score 58.2,E-value 1.1e-18 216596001120 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 216596001121 Pfam match to entry PF04909.2 Amidohydro_2, score 152.9, E-value 6.9e-43 216596001122 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216596001123 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 216596001124 Flavin binding site [chemical binding]; other site 216596001125 Pfam match to entry PF00441.11 Acyl-CoA_dh, score -14.6, E-value 0.00053 216596001126 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 216596001127 Pfam match to entry PF01613.6 Flavin_Reduct, score 131.4, E-value 2e-36 216596001128 MarR family; Region: MarR_2; cl17246 216596001129 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 216596001130 Pfam match to entry PF01047.8 MarR, score 78.3,E-value 2.1e-20 216596001131 Predicted helix-turn-helix motif with score 1290.000, SD 3.58 at aa 112-133, sequence STLGDLADVVSVEISTLSRLVG 216596001132 benzoate transport; Region: 2A0115; TIGR00895 216596001133 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596001134 putative substrate translocation pore; other site 216596001135 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596001136 12 probable transmembrane helices predicted at aa 61-83, 98-120, 132-154,159-181, 188-210, 215-237, 292-314, 324-346, 353-372,382-404, 417-439 and 443-465 216596001137 Pfam match to entry PF00083.10 Sugar_tr, score 62.1, E-value 1.5e-15 216596001138 Pfam match to entry PF07690.1 MFS_1, score 161.3,E-value 2.1e-45 216596001139 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3514 216596001140 4 probable transmembrane helices predicted at aa 12-34, 44-65, 78-100 and 105-127 216596001141 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216596001142 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596001143 dimer interface [polypeptide binding]; other site 216596001144 conserved gate region; other site 216596001145 putative PBP binding loops; other site 216596001146 ABC-ATPase subunit interface; other site 216596001147 Pfam match to entry PF00528.10 BPD_transp_1, score 62.6, E-value 1.1e-15 216596001148 6 probable transmembrane helices predicted at aa 19-41, 85-107, 119-141,151-173, 194-216 and 253-275 216596001149 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 216596001150 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596001151 dimer interface [polypeptide binding]; other site 216596001152 conserved gate region; other site 216596001153 putative PBP binding loops; other site 216596001154 ABC-ATPase subunit interface; other site 216596001155 Pfam match to entry PF00528.10 BPD_transp_1, score 39.7, E-value 8.5e-09 216596001156 8 probable transmembrane helices predicted at aa 25-47, 83-105, 118-140,144-166, 178-200, 220-239, 246-264 and 279-301 216596001157 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 216596001158 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 216596001159 Pfam match to entry PF01547.11 SBP_bac_1, score 56.3, E-value 8.6e-14 216596001160 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 216596001161 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 216596001162 Walker A/P-loop; other site 216596001163 ATP binding site [chemical binding]; other site 216596001164 Q-loop/lid; other site 216596001165 ABC transporter signature motif; other site 216596001166 Walker B; other site 216596001167 D-loop; other site 216596001168 H-loop/switch region; other site 216596001169 TOBE domain; Region: TOBE; pfam03459 216596001170 Pfam match to entry PF03459.4 TOBE, score 51.5,E-value 2.4e-12 216596001171 Pfam match to entry PF00005.11 ABC_tran, score 223.4, E-value 4.2e-64 216596001172 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 216596001173 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 216596001174 putative NAD(P) binding site [chemical binding]; other site 216596001175 active site 216596001176 putative substrate binding site [chemical binding]; other site 216596001177 transcriptional regulator NanR; Provisional; Region: PRK03837 216596001178 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596001179 DNA-binding site [nucleotide binding]; DNA binding site 216596001180 FCD domain; Region: FCD; pfam07729 216596001181 Pfam match to entry PF00392.9 GntR, score 66.5,E-value 7.4e-17 216596001182 Predicted helix-turn-helix motif with score 1054.000, SD 2.78 at aa 48-69, sequence PSERELASALSVSRETVRGAIL 216596001183 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 216596001184 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 216596001185 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 216596001186 active site 216596001187 DNA binding site [nucleotide binding] 216596001188 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 216596001189 DNA binding site [nucleotide binding] 216596001190 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 216596001191 nucleotide binding site [chemical binding]; other site 216596001192 Pfam match to entry PF04679.4 DNA_ligase_A_C, score 46.8, E-value 6e-11 216596001193 Pfam match to entry PF01068.9 DNA_ligase_A_M, score 102.8, E-value 8.4e-28 216596001194 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 216596001195 transmembrane helices; other site 216596001196 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 216596001197 TrkA-C domain; Region: TrkA_C; pfam02080 216596001198 TrkA-C domain; Region: TrkA_C; pfam02080 216596001199 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 216596001200 9 probable transmembrane helices predicted at aa 5-22, 29-51, 56-75, 96-118,177-199, 396-418, 484-506, 527-544 and 564-586 216596001201 Pfam match to entry PF02080.8 TrkA_C, score 43.8,E-value 4.9e-10 216596001202 Pfam match to entry PF02080.8 TrkA_C, score 36.7,E-value 6.7e-08 216596001203 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 216596001204 Pfam match to entry PF02615.4 Ldh_2, score 112.2,E-value 1.3e-30 216596001205 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 216596001206 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_12; cd08491 216596001207 Pfam match to entry PF00496.9 SBP_bac_5, score 82.0, E-value 1.5e-21 216596001208 Class I aldolases; Region: Aldolase_Class_I; cl17187 216596001209 Pfam match to entry PF00701.10 DHDPS, score 31.4,E-value 1.3e-08 216596001210 5-dehydro-4-deoxyglucarate dehydratase; Provisional; Region: PRK03620 216596001211 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 216596001212 catalytic residue [active] 216596001213 Pfam match to entry PF00701.10 DHDPS, score 58.5,E-value 1.9e-14 216596001214 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 216596001215 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 216596001216 dimer interface [polypeptide binding]; other site 216596001217 NADP binding site [chemical binding]; other site 216596001218 catalytic residues [active] 216596001219 Pfam match to entry PF00171.9 Aldedh, score -80.0, E-value 1.9e-13 216596001220 hypothetical protein; Validated; Region: PRK08245 216596001221 Pfam match to entry PF03737.4 Methyltransf_6, score 41.7, E-value 3.5e-11 216596001222 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 216596001223 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 216596001224 active site pocket [active] 216596001225 Pfam match to entry PF01188.9 MR_MLE, score 111.0, E-value 2.8e-30 216596001226 Pfam match to entry PF02746.4 MR_MLE_N, score 41.6, E-value 2.2e-09 216596001227 dihydroxy-acid dehydratase; Provisional; Region: PRK13016 216596001228 Pfam match to entry PF00920.9 ILVD_EDD, score 729.0, E-value 2.7e-216 216596001229 Transcriptional regulators [Transcription]; Region: GntR; COG1802 216596001230 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596001231 DNA-binding site [nucleotide binding]; DNA binding site 216596001232 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 216596001233 Pfam match to entry PF00392.9 GntR, score 60.1,E-value 6.1e-15 216596001234 Predicted helix-turn-helix motif with score 1115.000, SD 2.98 at aa 46-67, sequence LSRTELTETYEVSQTPIRDALQ 216596001235 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 216596001236 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 216596001237 putative ligand binding site [chemical binding]; other site 216596001238 NAD binding site [chemical binding]; other site 216596001239 catalytic site [active] 216596001240 Pfam match to entry PF02826.5 2-Hacid_dh_C, score 111.8, E-value 1.7e-30 216596001241 Pfam match to entry PF00389.15 2-Hacid_dh, score 36.5, E-value 7.7e-08 216596001242 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 216596001243 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596001244 Walker A/P-loop; other site 216596001245 ATP binding site [chemical binding]; other site 216596001246 Q-loop/lid; other site 216596001247 ABC transporter signature motif; other site 216596001248 Walker B; other site 216596001249 D-loop; other site 216596001250 H-loop/switch region; other site 216596001251 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216596001252 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596001253 Walker A/P-loop; other site 216596001254 ATP binding site [chemical binding]; other site 216596001255 Q-loop/lid; other site 216596001256 ABC transporter signature motif; other site 216596001257 Walker B; other site 216596001258 D-loop; other site 216596001259 H-loop/switch region; other site 216596001260 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 216596001261 Pfam match to entry PF00005.11 ABC_tran, score 224.7, E-value 1.7e-64 216596001262 Pfam match to entry PF00005.11 ABC_tran, score 214.9, E-value 1.5e-61 216596001263 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapC; COG4171 216596001264 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596001265 dimer interface [polypeptide binding]; other site 216596001266 conserved gate region; other site 216596001267 putative PBP binding loops; other site 216596001268 ABC-ATPase subunit interface; other site 216596001269 Pfam match to entry PF00528.10 BPD_transp_1, score 159.4, E-value 7.8e-45 216596001270 5 probable transmembrane helices predicted at aa 30-52, 100-122, 146-168,205-227 and 266-288 216596001271 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 216596001272 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596001273 dimer interface [polypeptide binding]; other site 216596001274 conserved gate region; other site 216596001275 putative PBP binding loops; other site 216596001276 ABC-ATPase subunit interface; other site 216596001277 Pfam match to entry PF00528.10 BPD_transp_1, score 152.4, E-value 9.8e-43 216596001278 7 probable transmembrane helices predicted at aa 37-59, 125-147, 160-182,197-219, 240-262, 266-288 and 300-322 216596001279 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 216596001280 8 probable transmembrane helices predicted at aa 9-31, 35-57, 70-92, 97-116,121-143, 148-167, 179-201 and 260-277 216596001281 Pfam match to entry PF00892.8 DUF6, score 49.9,E-value 6.9e-12 216596001282 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 216596001283 nudix motif; other site 216596001284 Pfam match to entry PF00293.13 NUDIX, score 66.7,E-value 6.4e-17 216596001285 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 216596001286 putative catalytic residues [active] 216596001287 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 216596001288 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 216596001289 Walker A/P-loop; other site 216596001290 ATP binding site [chemical binding]; other site 216596001291 Q-loop/lid; other site 216596001292 ABC transporter signature motif; other site 216596001293 Walker B; other site 216596001294 D-loop; other site 216596001295 H-loop/switch region; other site 216596001296 TOBE domain; Region: TOBE_2; pfam08402 216596001297 Pfam match to entry PF03459.4 TOBE, score 32.7,E-value 1e-06 216596001298 Pfam match to entry PF00005.11 ABC_tran, score 215.5, E-value 1e-61 216596001299 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; pfam08013 216596001300 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 216596001301 dimer interface [polypeptide binding]; other site 216596001302 active site 216596001303 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 216596001304 active site 216596001305 dimer interface [polypeptide binding]; other site 216596001306 Pfam match to entry PF01380.9 SIS, score 20.9,E-value 0.00041 216596001307 Pfam match to entry PF01380.9 SIS, score 34.2,E-value 3.8e-07 216596001308 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216596001309 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596001310 dimer interface [polypeptide binding]; other site 216596001311 conserved gate region; other site 216596001312 putative PBP binding loops; other site 216596001313 ABC-ATPase subunit interface; other site 216596001314 Pfam match to entry PF00528.10 BPD_transp_1, score 51.2, E-value 2.9e-12 216596001315 6 probable transmembrane helices predicted at aa 9-31, 84-106, 118-140,150-172, 193-215 and 250-272 216596001316 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596001317 dimer interface [polypeptide binding]; other site 216596001318 conserved gate region; other site 216596001319 putative PBP binding loops; other site 216596001320 ABC-ATPase subunit interface; other site 216596001321 Pfam match to entry PF00528.10 BPD_transp_1, score 49.1, E-value 1.3e-11 216596001322 6 probable transmembrane helices predicted at aa 21-43, 88-110, 117-139,170-192, 213-235 and 274-296 216596001323 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 216596001324 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 216596001325 Pfam match to entry PF01547.11 SBP_bac_1, score 101.4, E-value 2.2e-27 216596001326 1 probable transmembrane helix predicted at aa 21-38 216596001327 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 216596001328 Pfam match to entry PF01869.8 BcrAD_BadFG, score 73.2, E-value 6.9e-19 216596001329 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 216596001330 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 216596001331 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 216596001332 Pfam match to entry PF00455.10 DeoR, score 234.3,E-value 2.2e-67 216596001333 Predicted helix-turn-helix motif with score 1386.000, SD 3.91 at aa 25-46, sequence STIQALADAIGASLATVRRDLQ 216596001334 alpha-galactosidase; Provisional; Region: PRK15076 216596001335 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 216596001336 NAD binding site [chemical binding]; other site 216596001337 sugar binding site [chemical binding]; other site 216596001338 divalent metal binding site [ion binding]; other site 216596001339 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 216596001340 dimer interface [polypeptide binding]; other site 216596001341 Pfam match to entry PF02056.5 Glyco_hydro_4, score 464.1, E-value 1.5e-136 216596001342 Cupin domain; Region: Cupin_2; pfam07883 216596001343 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216596001344 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216596001345 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216596001346 Pfam match to entry PF00165.8 HTH_AraC, score 32.5, E-value 1.2e-06 216596001347 Predicted helix-turn-helix motif with score 1698.000, SD 4.97 at aa 150-171, sequence ISVADLAKLAGMHPSTANSAFR 216596001348 Pfam match to entry PF00165.8 HTH_AraC, score 42.4, E-value 1.3e-09 216596001349 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 216596001350 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 216596001351 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 216596001352 Zn2+ binding site [ion binding]; other site 216596001353 Mg2+ binding site [ion binding]; other site 216596001354 Pfam match to entry PF01966.8 HD, score 95.6,E-value 1.3e-25 216596001355 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 216596001356 GAF domain; Region: GAF; pfam01590 216596001357 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 216596001358 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216596001359 metal binding site [ion binding]; metal-binding site 216596001360 active site 216596001361 I-site; other site 216596001362 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216596001363 Pfam match to entry PF00563.9 EAL, score 266.8,E-value 3.7e-77 216596001364 Pfam match to entry PF00990.8 GGDEF, score 120.0,E-value 5.5e-33 216596001365 Pfam match to entry PF01590.11 GAF, score 47.4,E-value 4.1e-11 216596001366 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 216596001367 Transcriptional regulators [Transcription]; Region: PurR; COG1609 216596001368 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216596001369 DNA binding site [nucleotide binding] 216596001370 domain linker motif; other site 216596001371 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 216596001372 ligand binding site [chemical binding]; other site 216596001373 Predicted helix-turn-helix motif with score 1714.000, SD 5.02 at aa 2-23, sequence ANLKQLAQSLGLSITTVSRALD 216596001374 Pfam match to entry PF00532.8 Peripla_BP_1, score 54.1, E-value 4e-13 216596001375 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 216596001376 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 216596001377 1 probable transmembrane helix predicted at aa 16-38 216596001378 Pfam match to entry PF01547.11 SBP_bac_1, score 24.8, E-value 0.00026 216596001379 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 216596001380 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596001381 dimer interface [polypeptide binding]; other site 216596001382 conserved gate region; other site 216596001383 putative PBP binding loops; other site 216596001384 ABC-ATPase subunit interface; other site 216596001385 6 probable transmembrane helices predicted at aa 7-29, 64-86, 95-117, 149-171,211-230 and 250-272 216596001386 Pfam match to entry PF00528.10 BPD_transp_1, score 52.1, E-value 1.5e-12 216596001387 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216596001388 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596001389 dimer interface [polypeptide binding]; other site 216596001390 conserved gate region; other site 216596001391 putative PBP binding loops; other site 216596001392 ABC-ATPase subunit interface; other site 216596001393 6 probable transmembrane helices predicted at aa 24-46, 89-111, 123-145,155-177, 198-220 and 255-277 216596001394 Pfam match to entry PF00528.10 BPD_transp_1, score 65.1, E-value 1.8e-16 216596001395 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 216596001396 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216596001397 Walker A/P-loop; other site 216596001398 ATP binding site [chemical binding]; other site 216596001399 Q-loop/lid; other site 216596001400 ABC transporter signature motif; other site 216596001401 Walker B; other site 216596001402 D-loop; other site 216596001403 H-loop/switch region; other site 216596001404 Pfam match to entry PF00005.11 ABC_tran, score 232.8, E-value 6.1e-67 216596001405 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 216596001406 Trehalase; Region: Trehalase; cl17346 216596001407 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 216596001408 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 216596001409 AAA domain; Region: AAA_23; pfam13476 216596001410 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 216596001411 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 216596001412 active site 216596001413 metal binding site [ion binding]; metal-binding site 216596001414 DNA binding site [nucleotide binding] 216596001415 Pfam match to entry PF00149.12 Metallophos, score 51.0, E-value 3.4e-12 216596001416 acetolactate synthase; Reviewed; Region: PRK08322 216596001417 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 216596001418 PYR/PP interface [polypeptide binding]; other site 216596001419 dimer interface [polypeptide binding]; other site 216596001420 TPP binding site [chemical binding]; other site 216596001421 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 216596001422 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 216596001423 TPP-binding site [chemical binding]; other site 216596001424 dimer interface [polypeptide binding]; other site 216596001425 Pfam match to entry PF00205.10 TPP_enzyme_M, score 91.9, E-value 1.7e-24 216596001426 Pfam match to entry PF02776.6 TPP_enzyme_N, score 164.2, E-value 2.8e-46 216596001427 1 probable transmembrane helix predicted at aa 30-49 216596001428 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 216596001429 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 216596001430 Pfam match to entry PF00375.7 SDF, score 482.5,E-value 4.1e-142 216596001431 9 probable transmembrane helices predicted at aa 25-47, 62-84, 97-119, 168-187,208-227, 242-264, 309-331, 351-373 and 378-400 216596001432 similarity:fasta; SWALL:Q8PF31 (EMBL:AE012066); Xanthomonas axonopodis; acyl transferase; fldZ; length 223 aa; id=61.29; ungapped id=61.29; E()=9.3e-09; 62 aa overlap; query 1-62 aa; subject 1-62 aa; putative acyl transferase, pseudogene 216596001433 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596001434 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596001435 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 216596001436 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596001437 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216596001438 dimerization interface [polypeptide binding]; other site 216596001439 Pfam match to entry PF00126.10 HTH_1, score 58.2,E-value 2.2e-14 216596001440 Predicted helix-turn-helix motif with score 1271.000, SD 3.52 at aa 22-43, sequence GSISSASHTMNLSQPALTQAVA 216596001441 Predicted helix-turn-helix motif with score 1271.000, SD 3.52 at aa 119-43, sequence AKVEAQLGHVLFDRQPSGVTSTEAGRLITARIERALAYVARGGQSVRRGARLPPLPH IERRITFGQLRALIAVDQAG 216596001442 Pfam match to entry PF00126.10 HTH_1, score 63.3,E-value 6.7e-16 216596001443 Predicted helix-turn-helix motif with score 1063.000, SD 2.81 at aa 119-140, sequence GSFALASKRIGLSEPALHRASR 216596001444 Pfam match to entry PF03466.5 LysR_substrate, score 122.3, E-value 1.1e-33 216596001445 Amidohydrolase; Region: Amidohydro_2; pfam04909 216596001446 Pfam match to entry PF04909.2 Amidohydro_2, score 366.4, E-value 3.8e-107 216596001447 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 216596001448 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311 216596001449 active site 216596001450 Pfam match to entry PF04909.2 Amidohydro_2, score 0.8, E-value 1.5e-05 216596001451 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 216596001452 Pfam match to entry PF03401.3 Bug, score 293.4,E-value 3.6e-85 216596001453 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 216596001454 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 216596001455 protein binding site [polypeptide binding]; other site 216596001456 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 216596001457 Catalytic dyad [active] 216596001458 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 216596001459 Pfam match to entry PF03572.6 Peptidase_S41, score 223.6, E-value 3.7e-64 216596001460 Pfam match to entry PF00595.8 PDZ, score 58.6,E-value 1.7e-14 216596001461 MEKHLA domain; Region: MEKHLA; pfam08670 216596001462 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 216596001463 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216596001464 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596001465 homodimer interface [polypeptide binding]; other site 216596001466 catalytic residue [active] 216596001467 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 216596001468 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596001469 active site 216596001470 phosphorylation site [posttranslational modification] 216596001471 intermolecular recognition site; other site 216596001472 dimerization interface [polypeptide binding]; other site 216596001473 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 216596001474 DNA binding residues [nucleotide binding] 216596001475 Predicted helix-turn-helix motif with score 1133.000, SD 3.05 at aa 164-185, sequence LTDRAIAKRRGLSLRSVQNRLQ 216596001476 Pfam match to entry PF00072.10 Response_reg, score 56.6, E-value 7.1e-14 216596001477 GAF domain; Region: GAF; cl17456 216596001478 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 216596001479 Histidine kinase; Region: HisKA_3; pfam07730 216596001480 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596001481 ATP binding site [chemical binding]; other site 216596001482 Mg2+ binding site [ion binding]; other site 216596001483 G-X-G motif; other site 216596001484 Pfam match to entry PF02518.9 HATPase_c, score 63.7, E-value 4.8e-16 216596001485 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 216596001486 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 216596001487 putative ligand binding site [chemical binding]; other site 216596001488 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 216596001489 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 216596001490 Walker A/P-loop; other site 216596001491 ATP binding site [chemical binding]; other site 216596001492 Q-loop/lid; other site 216596001493 ABC transporter signature motif; other site 216596001494 Walker B; other site 216596001495 D-loop; other site 216596001496 H-loop/switch region; other site 216596001497 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 216596001498 Pfam match to entry PF00005.11 ABC_tran, score 153.0, E-value 6.6e-43 216596001499 Pfam match to entry PF00005.11 ABC_tran, score 32.2, E-value 1.9e-08 216596001500 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596001501 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216596001502 TM-ABC transporter signature motif; other site 216596001503 9 probable transmembrane helices predicted at aa 10-29, 36-58, 88-110, 117-139,159-181, 202-224, 234-256, 261-283 and 288-305 216596001504 Pfam match to entry PF02653.5 BPD_transp_2, score 168.9, E-value 1.1e-47 216596001505 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216596001506 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596001507 TM-ABC transporter signature motif; other site 216596001508 9 probable transmembrane helices predicted at aa 13-35, 42-64, 93-115, 120-139,159-181, 212-234, 244-261, 266-288 and 292-310 216596001509 Pfam match to entry PF02653.5 BPD_transp_2, score 128.0, E-value 2.2e-35 216596001510 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 216596001511 Strictosidine synthase; Region: Str_synth; pfam03088 216596001512 Pfam match to entry PF03758.3 SMP-30, score 0.7,E-value 1e-10 216596001513 choline dehydrogenase; Validated; Region: PRK02106 216596001514 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 216596001515 Pfam match to entry PF05199.2 GMC_oxred_C, score 136.3, E-value 7.1e-38 216596001516 Pfam match to entry PF00732.8 GMC_oxred_N, score 313.3, E-value 3.7e-91 216596001517 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216596001518 Serine hydrolase; Region: Ser_hydrolase; cl17834 216596001519 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 216596001520 MarR family; Region: MarR; pfam01047 216596001521 Pfam match to entry PF01047.8 MarR, score 68.8,E-value 1.5e-17 216596001522 short chain dehydrogenase; Provisional; Region: PRK06523 216596001523 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216596001524 NAD(P) binding site [chemical binding]; other site 216596001525 active site 216596001526 Pfam match to entry PF00106.11 adh_short, score 134.4, E-value 2.7e-37 216596001527 SnoaL-like domain; Region: SnoaL_2; pfam12680 216596001528 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596001529 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596001530 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 216596001531 putative effector binding pocket; other site 216596001532 putative dimerization interface [polypeptide binding]; other site 216596001533 Pfam match to entry PF00126.10 HTH_1, score 66.8,E-value 5.6e-17 216596001534 Predicted helix-turn-helix motif with score 1202.000, SD 3.28 at aa 19-40, sequence GTFRAAAIDLGMSTTALSHTIG 216596001535 Pfam match to entry PF03466.5 LysR_substrate, score 158.4, E-value 1.6e-44 216596001536 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596001537 putative substrate translocation pore; other site 216596001538 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216596001539 11 probable transmembrane helices predicted at aa 39-61, 68-90, 100-119,126-148, 189-211, 239-261, 271-293, 302-321, 326-348,360-382 and 392-409 216596001540 Pfam match to entry PF07690.1 MFS_1, score 78.5,E-value 1.7e-20 216596001541 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216596001542 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216596001543 Pfam match to entry PF00440.8 TetR_N, score 55.8,E-value 1.2e-13 216596001544 Epoxide hydrolase N terminus; Region: EHN; pfam06441 216596001545 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 216596001546 1 probable transmembrane helix predicted at aa 13-35 216596001547 Pfam match to entry PF06441.1 EHN, score 203.0,E-value 5.9e-58 216596001548 Pfam match to entry PF00561.8 Abhydrolase_1, score 25.9, E-value 0.00012 216596001549 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 216596001550 Ligand binding site; other site 216596001551 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 216596001552 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 216596001553 XdhC Rossmann domain; Region: XdhC_C; pfam13478 216596001554 Pfam match to entry PF02625.5 XdhC_CoxI, score 79.4, E-value 9.2e-21 216596001555 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 216596001556 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 216596001557 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 216596001558 Pfam match to entry PF02738.5 Ald_Xan_dh_C2, score 473.7, E-value 1.9e-139 216596001559 Pfam match to entry PF01315.9 Ald_Xan_dh_C, score 107.8, E-value 2.7e-29 216596001560 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 216596001561 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 216596001562 Pfam match to entry PF00941.7 FAD_binding_5, score -0.8, E-value 1.6e-06 216596001563 aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433 216596001564 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 216596001565 catalytic loop [active] 216596001566 iron binding site [ion binding]; other site 216596001567 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 216596001568 Pfam match to entry PF01799.6 Fer2_2, score 143.7, E-value 4.1e-40 216596001569 Pfam match to entry PF00111.12 Fer2, score 50.5,E-value 4.8e-12 216596001570 Creatinine amidohydrolase; Region: Creatininase; pfam02633 216596001571 Pfam match to entry PF02633.4 Creatininase, score 90.2, E-value 5.2e-24 216596001572 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596001573 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596001574 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216596001575 dimerization interface [polypeptide binding]; other site 216596001576 Pfam match to entry PF03466.5 LysR_substrate, score 131.7, E-value 1.7e-36 216596001577 Pfam match to entry PF00126.10 HTH_1, score 73.4,E-value 5.9e-19 216596001578 Predicted helix-turn-helix motif with score 1263.000, SD 3.49 at aa 17-38, sequence GSIRKAAARLNVASSAVNRQIL 216596001579 NMT1/THI5 like; Region: NMT1; pfam09084 216596001580 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 216596001581 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 216596001582 Walker A/P-loop; other site 216596001583 ATP binding site [chemical binding]; other site 216596001584 Q-loop/lid; other site 216596001585 ABC transporter signature motif; other site 216596001586 Walker B; other site 216596001587 D-loop; other site 216596001588 H-loop/switch region; other site 216596001589 Pfam match to entry PF00005.11 ABC_tran, score 187.4, E-value 2.9e-53 216596001590 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 216596001591 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596001592 dimer interface [polypeptide binding]; other site 216596001593 conserved gate region; other site 216596001594 ABC-ATPase subunit interface; other site 216596001595 7 probable transmembrane helices predicted at aa 24-46, 56-78, 85-107, 111-133,140-162, 202-224 and 244-266 216596001596 Pfam match to entry PF00528.10 BPD_transp_1, score 85.0, E-value 2e-22 216596001597 cytosine deaminase-like protein; Validated; Region: PRK07583 216596001598 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 216596001599 active site 216596001600 Pfam match to entry PF01979.7 Amidohydro_1, score -10.8, E-value 0.0017 216596001601 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 216596001602 FAD binding domain; Region: FAD_binding_4; pfam01565 216596001603 Pfam match to entry PF01565.10 FAD_binding_4, score 149.4, E-value 8e-42 216596001604 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 216596001605 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 216596001606 Pfam match to entry PF02525.5 Flavodoxin_2, score 140.1, E-value 4.9e-39 216596001607 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 216596001608 homotrimer interaction site [polypeptide binding]; other site 216596001609 putative active site [active] 216596001610 Pfam match to entry PF01042.8 Ribonuc_L-PSP, score 73.1, E-value 7.3e-19 216596001611 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 216596001612 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 216596001613 dimerization interface [polypeptide binding]; other site 216596001614 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216596001615 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 216596001616 dimer interface [polypeptide binding]; other site 216596001617 putative CheW interface [polypeptide binding]; other site 216596001618 Pfam match to entry PF00015.9 MCPsignal, score 301.1, E-value 1.7e-87 216596001619 Pfam match to entry PF00672.10 HAMP, score 57.2,E-value 4.4e-14 216596001620 2 probable transmembrane helices predicted at aa 76-98 and 257-279 216596001621 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 216596001622 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 216596001623 Pfam match to entry PF01648.8 ACPS, score 48.3,E-value 2.1e-11 216596001624 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 216596001625 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 216596001626 Condensation domain; Region: Condensation; pfam00668 216596001627 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 216596001628 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 216596001629 acyl-activating enzyme (AAE) consensus motif; other site 216596001630 AMP binding site [chemical binding]; other site 216596001631 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 216596001632 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 216596001633 Pfam match to entry PF00975.7 Thioesterase, score 10.8, E-value 1.7e-05 216596001634 Pfam match to entry PF00550.9 PP-binding, score 48.8, E-value 1.6e-11 216596001635 Pfam match to entry PF00501.11 AMP-binding, score 429.6, E-value 3.6e-126 216596001636 Pfam match to entry PF00668.8 Condensation, score 30.7, E-value 2.2e-09 216596001637 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 216596001638 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 216596001639 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 216596001640 putative efflux protein, MATE family; Region: matE; TIGR00797 216596001641 Pfam match to entry PF01554.8 MatE, score 85.7,E-value 1.2e-22 216596001642 11 probable transmembrane helices predicted at aa 64-86, 107-129, 149-171,178-200, 204-226, 247-269, 284-306, 327-349, 364-383,403-425 and 429-451 216596001643 hypothetical protein; Provisional; Region: PRK05968 216596001644 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 216596001645 homodimer interface [polypeptide binding]; other site 216596001646 substrate-cofactor binding pocket; other site 216596001647 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596001648 catalytic residue [active] 216596001649 Pfam match to entry PF01053.8 Cys_Met_Meta_PP, score 330.9, E-value 1.8e-96 216596001650 extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037 216596001651 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216596001652 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 216596001653 Predicted helix-turn-helix motif with score 1499.000, SD 4.29 at aa 138-159, sequence VPQKDIAAELGVSRTLVNFMIK 216596001654 Pfam match to entry PF04542.2 Sigma70_r2, score 30.7, E-value 4.2e-06 216596001655 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 216596001656 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216596001657 Coenzyme A binding pocket [chemical binding]; other site 216596001658 Pfam match to entry PF00583.9 Acetyltransf_1, score 32.0, E-value 1.7e-06 216596001659 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 216596001660 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 216596001661 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 216596001662 Pfam match to entry PF06276.1 FhuF, score 414.3,E-value 1.4e-121 216596001663 1 probable transmembrane helix predicted at aa 82-104 216596001664 ferrioxamine B receptor precursor protein; Provisional; Region: PRK14049 216596001665 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216596001666 N-terminal plug; other site 216596001667 ligand-binding site [chemical binding]; other site 216596001668 Pfam match to entry PF00593.9 TonB_dep_Rec, score 380.0, E-value 2.9e-111 216596001669 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 216596001670 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216596001671 metal binding site [ion binding]; metal-binding site 216596001672 active site 216596001673 I-site; other site 216596001674 5 probable transmembrane helices predicted at aa 64-86, 91-113, 118-140,155-188 and 195-217 216596001675 Pfam match to entry PF00990.8 GGDEF, score 199.7,E-value 5.7e-57 216596001676 Transcriptional regulators [Transcription]; Region: FadR; COG2186 216596001677 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596001678 DNA-binding site [nucleotide binding]; DNA binding site 216596001679 FCD domain; Region: FCD; pfam07729 216596001680 Pfam match to entry PF00392.9 GntR, score 70.8,E-value 3.6e-18 216596001681 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 216596001682 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 216596001683 1 probable transmembrane helix predicted at aa 7-29 216596001684 Pfam match to entry PF00496.9 SBP_bac_5, score 73.3, E-value 6.6e-19 216596001685 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 216596001686 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596001687 dimer interface [polypeptide binding]; other site 216596001688 conserved gate region; other site 216596001689 putative PBP binding loops; other site 216596001690 ABC-ATPase subunit interface; other site 216596001691 6 probable transmembrane helices predicted at aa 9-31,103-125,138-160,182-201,240-262,282-304 216596001692 Pfam match to entry PF00528.10 BPD_transp_1, score 181.00, E-value 1.7e-51 216596001693 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 216596001694 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596001695 dimer interface [polypeptide binding]; other site 216596001696 conserved gate region; other site 216596001697 putative PBP binding loops; other site 216596001698 ABC-ATPase subunit interface; other site 216596001699 5 probable transmembrane helices predicted at aa 360-382, 423-445, 465-496,553-575 and 590-612 216596001700 Pfam match to entry PF00528.10 BPD_transp_1, score 159.4, E-value 7.9e-45 216596001701 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 216596001702 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 216596001703 inhibitor site; inhibition site 216596001704 active site 216596001705 dimer interface [polypeptide binding]; other site 216596001706 catalytic residue [active] 216596001707 Pfam match to entry PF00701.10 DHDPS, score 117.9, E-value 2.4e-32 216596001708 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 216596001709 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596001710 Walker A/P-loop; other site 216596001711 ATP binding site [chemical binding]; other site 216596001712 Q-loop/lid; other site 216596001713 ABC transporter signature motif; other site 216596001714 Walker B; other site 216596001715 D-loop; other site 216596001716 H-loop/switch region; other site 216596001717 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 216596001718 Pfam match to entry PF00005.11 ABC_tran, score 193.5, E-value 4.1e-55 216596001719 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 216596001720 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596001721 Walker A/P-loop; other site 216596001722 ATP binding site [chemical binding]; other site 216596001723 Q-loop/lid; other site 216596001724 ABC transporter signature motif; other site 216596001725 Walker B; other site 216596001726 D-loop; other site 216596001727 H-loop/switch region; other site 216596001728 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 216596001729 Pfam match to entry PF00005.11 ABC_tran, score 212.7, E-value 6.8e-61 216596001730 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 216596001731 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 216596001732 inhibitor site; inhibition site 216596001733 active site 216596001734 dimer interface [polypeptide binding]; other site 216596001735 catalytic residue [active] 216596001736 Pfam match to entry PF00701.10 DHDPS, score -72.8, E-value 7.1e-07 216596001737 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 216596001738 Transcriptional regulator [Transcription]; Region: IclR; COG1414 216596001739 Bacterial transcriptional regulator; Region: IclR; pfam01614 216596001740 Pfam match to entry PF01614.6 IclR, score 150.9,E-value 2.7e-42 216596001741 Predicted helix-turn-helix motif with score 1386.000, SD 3.91 at aa 31-52, sequence IRLTEVAQNLGETKPRILRMLR 216596001742 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 216596001743 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 216596001744 Pfam match to entry PF00496.9 SBP_bac_5, score 70.7, E-value 4e-18 216596001745 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 216596001746 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 216596001747 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 216596001748 Pfam match to entry PF01019.9 G_glu_transpept, score 460.4, E-value 1.9e-135 216596001749 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 216596001750 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596001751 dimer interface [polypeptide binding]; other site 216596001752 conserved gate region; other site 216596001753 putative PBP binding loops; other site 216596001754 ABC-ATPase subunit interface; other site 216596001755 6 probable transmembrane helices predicted at aa 12-34, 100-122, 134-156,176-198, 241-263 and 288-307 216596001756 Pfam match to entry PF00528.10 BPD_transp_1, score 200.5, E-value 3.3e-57 216596001757 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 216596001758 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 216596001759 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596001760 dimer interface [polypeptide binding]; other site 216596001761 conserved gate region; other site 216596001762 putative PBP binding loops; other site 216596001763 ABC-ATPase subunit interface; other site 216596001764 5 probable transmembrane helices predicted at aa 31-53, 107-129, 149-171,209-231 and 269-291 216596001765 Pfam match to entry PF00528.10 BPD_transp_1, score 162.0, E-value 1.2e-45 216596001766 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 216596001767 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596001768 Walker A/P-loop; other site 216596001769 ATP binding site [chemical binding]; other site 216596001770 Q-loop/lid; other site 216596001771 ABC transporter signature motif; other site 216596001772 Walker B; other site 216596001773 D-loop; other site 216596001774 H-loop/switch region; other site 216596001775 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216596001776 Pfam match to entry PF00005.11 ABC_tran, score 198.1, E-value 1.7e-56 216596001777 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 216596001778 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596001779 Walker A/P-loop; other site 216596001780 ATP binding site [chemical binding]; other site 216596001781 Q-loop/lid; other site 216596001782 ABC transporter signature motif; other site 216596001783 Walker B; other site 216596001784 D-loop; other site 216596001785 H-loop/switch region; other site 216596001786 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 216596001787 Pfam match to entry PF00005.11 ABC_tran, score 199.5, E-value 6.4e-57 216596001788 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 216596001789 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 216596001790 Pfam match to entry PF03734.4 ErfK_YbiS_YhnG, score 201.7, E-value 1.4e-57 216596001791 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 216596001792 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 216596001793 ligand binding site [chemical binding]; other site 216596001794 Pfam match to entry PF00691.7 OmpA, score 56.7,E-value 6.4e-14 216596001795 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 216596001796 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 216596001797 putative dimer interface [polypeptide binding]; other site 216596001798 Pfam match to entry PF00011.8 HSP20, score 76.6,E-value 6.5e-20 216596001799 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 216596001800 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 216596001801 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 216596001802 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 216596001803 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 216596001804 Pfam match to entry PF01915.10 Glyco_hydro_3_C, score 316.5, E-value 3.9e-92 216596001805 Pfam match to entry PF07691.1 PA14, score 59.7,E-value 8e-15 216596001806 Pfam match to entry PF00933.10 Glyco_hydro_3, score 425.6, E-value 5.6e-125 216596001807 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216596001808 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216596001809 Pfam match to entry PF00440.8 TetR_N, score 54.1,E-value 3.9e-13 216596001810 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216596001811 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 216596001812 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596001813 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596001814 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 216596001815 putative effector binding pocket; other site 216596001816 dimerization interface [polypeptide binding]; other site 216596001817 Pfam match to entry PF00126.10 HTH_1, score 68.5,E-value 1.8e-17 216596001818 Predicted helix-turn-helix motif with score 1015.000, SD 2.64 at aa 17-38, sequence QSYVAAARVGGVSPSAIGKAVA 216596001819 Pfam match to entry PF03466.5 LysR_substrate, score 197.5, E-value 2.7e-56 216596001820 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 216596001821 active site 216596001822 catalytic site [active] 216596001823 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 216596001824 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 216596001825 Pfam match to entry PF01074.9 Glyco_hydro_38, score 24.9, E-value 1.4e-14 216596001826 MarR family; Region: MarR_2; pfam12802 216596001827 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 216596001828 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 216596001829 Predicted helix-turn-helix motif with score 1036.000, SD 2.72 at aa 49-70, sequence LTRMELGGHCGLTGPGITNILR 216596001830 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 216596001831 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 216596001832 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 216596001833 Pfam match to entry PF02894.4 GFO_IDH_MocA_C, score 15.0, E-value 0.011 216596001834 Pfam match to entry PF01408.8 GFO_IDH_MocA, score 110.1, E-value 5.4e-30 216596001835 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 216596001836 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 216596001837 Pfam match to entry PF01547.11 SBP_bac_1, score 41.1, E-value 3.3e-09 216596001838 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596001839 dimer interface [polypeptide binding]; other site 216596001840 conserved gate region; other site 216596001841 putative PBP binding loops; other site 216596001842 ABC-ATPase subunit interface; other site 216596001843 6 probable transmembrane helices predicted at aa 57-79, 120-142, 155-177,197-219, 264-286 and 315-337 216596001844 Pfam match to entry PF00528.10 BPD_transp_1, score 31.3, E-value 2.8e-06 216596001845 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216596001846 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596001847 dimer interface [polypeptide binding]; other site 216596001848 conserved gate region; other site 216596001849 putative PBP binding loops; other site 216596001850 ABC-ATPase subunit interface; other site 216596001851 6 probable transmembrane helices predicted at aa 13-35, 79-98, 110-132,142-164, 185-207 and 243-265 216596001852 Pfam match to entry PF00528.10 BPD_transp_1, score 62.5, E-value 1.1e-15 216596001853 MarR family; Region: MarR; pfam01047 216596001854 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 216596001855 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 216596001856 Predicted helix-turn-helix motif with score 1515.000, SD 4.35 at aa 53-74, sequence ISRAEIARRTGFTKPAIARIVD 216596001857 Pfam match to entry PF00480.8 ROK, score 14.0,E-value 8.9e-08 216596001858 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 216596001859 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 216596001860 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 216596001861 Walker A/P-loop; other site 216596001862 ATP binding site [chemical binding]; other site 216596001863 Q-loop/lid; other site 216596001864 ABC transporter signature motif; other site 216596001865 Walker B; other site 216596001866 D-loop; other site 216596001867 H-loop/switch region; other site 216596001868 TOBE domain; Region: TOBE_2; pfam08402 216596001869 Pfam match to entry PF00005.11 ABC_tran, score 217.1, E-value 3.4e-62 216596001870 Homeodomain-like domain; Region: HTH_23; pfam13384 216596001871 Winged helix-turn helix; Region: HTH_29; pfam13551 216596001872 Homeodomain-like domain; Region: HTH_32; pfam13565 216596001873 DDE superfamily endonuclease; Region: DDE_3; pfam13358 216596001874 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 216596001875 Pfam match to entry PF00665.10 rve, score 26.1,E-value 7.6e-07 216596001876 Predicted helix-turn-helix motif with score 1274.000, SD 3.53 at aa 112-133, sequence WSIRSMAADSGLSHTTIRRIWT 216596001877 Predicted helix-turn-helix motif with score 1489.000, SD 4.26 at aa 112-67, sequence RRFVQDGIEGLTDEYRAGRPRTVSDAQVAQVVERTLNVTPKDATHW 216596001878 Predicted helix-turn-helix motif with score 1489.000, SD 4.26 at aa 46-67, sequence LQSKDVAERLGVHEHTVGKWRR 216596001879 ProQ/FINO family; Region: ProQ; pfam04352 216596001880 pantoate--beta-alanine ligase; Region: panC; TIGR00018 216596001881 Pantoate-beta-alanine ligase; Region: PanC; cd00560 216596001882 active site 216596001883 ATP-binding site [chemical binding]; other site 216596001884 pantoate-binding site; other site 216596001885 HXXH motif; other site 216596001886 Pfam match to entry PF02569.4 Pantoate_ligase, score 419.6, E-value 3.6e-123 216596001887 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 216596001888 oligomerization interface [polypeptide binding]; other site 216596001889 active site 216596001890 metal binding site [ion binding]; metal-binding site 216596001891 Pfam match to entry PF02548.4 Pantoate_transf, score 435.5, E-value 5.8e-128 216596001892 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596001893 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596001894 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 216596001895 dimerization interface [polypeptide binding]; other site 216596001896 Pfam match to entry PF03466.5 LysR_substrate, score 155.1, E-value 1.5e-43 216596001897 Pfam match to entry PF00126.10 HTH_1, score 78.2,E-value 2.2e-20 216596001898 Predicted helix-turn-helix motif with score 1423.000, SD 4.03 at aa 19-40, sequence GRFRRAADACAISQPALSMQIK 216596001899 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 216596001900 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 216596001901 dimer interface [polypeptide binding]; other site 216596001902 active site 216596001903 heme binding site [chemical binding]; other site 216596001904 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 216596001905 Pfam match to entry PF00141.9 peroxidase, score 318.9, E-value 7.7e-93 216596001906 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 216596001907 oligomeric interface; other site 216596001908 putative active site [active] 216596001909 homodimer interface [polypeptide binding]; other site 216596001910 Pfam match to entry PF01850.8 PIN, score 95.4,E-value 1.4e-25 216596001911 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 216596001912 Pfam match to entry PF04014.4 SpoVT_AbrB, score 26.3, E-value 9.2e-05 216596001913 Protein of unknown function (DUF3299); Region: DUF3299; cl01387 216596001914 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 216596001915 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 216596001916 NADP binding site [chemical binding]; other site 216596001917 dimer interface [polypeptide binding]; other site 216596001918 Pfam match to entry PF00107.11 ADH_zinc_N, score 138.9, E-value 1.2e-38 216596001919 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 216596001920 active site 216596001921 Pfam match to entry PF03061.8 4HBT, score 47.4,E-value 4.1e-11 216596001922 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 216596001923 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 216596001924 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 216596001925 acyl-activating enzyme (AAE) consensus motif; other site 216596001926 AMP binding site [chemical binding]; other site 216596001927 active site 216596001928 CoA binding site [chemical binding]; other site 216596001929 Pfam match to entry PF00501.11 AMP-binding, score 190.6, E-value 3.1e-54 216596001930 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 216596001931 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 216596001932 dimer interface [polypeptide binding]; other site 216596001933 active site 216596001934 Pfam match to entry PF00108.10 Thiolase_N, score 271.4, E-value 1.5e-78 216596001935 Pfam match to entry PF02803.5 Thiolase_C, score 105.6, E-value 1.2e-28 216596001936 1 probable transmembrane helix predicted at aa 373-395 216596001937 Transposase; Region: DEDD_Tnp_IS110; pfam01548 216596001938 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 216596001939 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 216596001940 Pfam match to entry PF02371.5 Transposase_20, score 89.8, E-value 7e-24 216596001941 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216596001942 NADH(P)-binding; Region: NAD_binding_10; pfam13460 216596001943 NAD(P) binding site [chemical binding]; other site 216596001944 active site 216596001945 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 216596001946 methionine gamma-lyase; Validated; Region: PRK07049 216596001947 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 216596001948 homodimer interface [polypeptide binding]; other site 216596001949 substrate-cofactor binding pocket; other site 216596001950 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596001951 catalytic residue [active] 216596001952 Pfam match to entry PF01053.8 Cys_Met_Meta_PP, score 396.9, E-value 2.4e-116 216596001953 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 216596001954 Pfam match to entry PF03631.3 Ribonuclease_BN, score 222.6, E-value 7.3e-64 216596001955 7 probable transmembrane helices predicted at aa 47-64, 116-138, 183-205,226-248, 268-290, 302-324 and 334-356 216596001956 ccgtggcgccacgg 216596001957 ccgtggcgccacgg 216596001958 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 216596001959 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596001960 S-adenosylmethionine binding site [chemical binding]; other site 216596001961 Pfam match to entry PF01135.8 PCMT, score -5.7,E-value 1.1e-08 216596001962 Protein of unknown function (DUF972); Region: DUF972; pfam06156 216596001963 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 216596001964 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 216596001965 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 216596001966 Pfam match to entry PF00583.9 Acetyltransf_1, score 21.3, E-value 0.0028 216596001967 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 216596001968 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 216596001969 Walker A/P-loop; other site 216596001970 ATP binding site [chemical binding]; other site 216596001971 Q-loop/lid; other site 216596001972 ABC transporter signature motif; other site 216596001973 Walker B; other site 216596001974 D-loop; other site 216596001975 H-loop/switch region; other site 216596001976 TOBE domain; Region: TOBE_2; pfam08402 216596001977 Pfam match to entry PF03459.4 TOBE, score 37.3,E-value 4.3e-08 216596001978 Pfam match to entry PF00005.11 ABC_tran, score 227.2, E-value 3e-65 216596001979 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 216596001980 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216596001981 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596001982 dimer interface [polypeptide binding]; other site 216596001983 conserved gate region; other site 216596001984 putative PBP binding loops; other site 216596001985 ABC-ATPase subunit interface; other site 216596001986 Pfam match to entry PF00528.10 BPD_transp_1, score 93.9, E-value 4.1e-25 216596001987 6 probable transmembrane helices predicted at aa 26-48, 91-113, 125-147,157-179, 200-222 and 257-279 216596001988 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 216596001989 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596001990 dimer interface [polypeptide binding]; other site 216596001991 conserved gate region; other site 216596001992 putative PBP binding loops; other site 216596001993 ABC-ATPase subunit interface; other site 216596001994 Pfam match to entry PF00528.10 BPD_transp_1, score 49.7, E-value 8.3e-12 216596001995 5 probable transmembrane helices predicted at aa 12-34, 76-98, 110-127, 160-182 and 266-288 216596001996 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 216596001997 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 216596001998 Pfam match to entry PF01547.11 SBP_bac_1, score 60.5, E-value 4.5e-15 216596001999 DAK2 domain; Region: Dak2; cl03685 216596002000 Pfam match to entry PF02734.5 Dak2, score 216.7,E-value 4.3e-62 216596002001 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 216596002002 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 216596002003 Pfam match to entry PF02733.5 Dak1, score 366.4,E-value 3.7e-107 216596002004 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 216596002005 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 216596002006 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 216596002007 Pfam match to entry PF02894.4 GFO_IDH_MocA_C, score 17.8, E-value 0.0055 216596002008 Pfam match to entry PF01408.8 GFO_IDH_MocA, score 82.0, E-value 1.5e-21 216596002009 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216596002010 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596002011 TM-ABC transporter signature motif; other site 216596002012 7 probable transmembrane helices predicted at aa 28-45, 58-77, 81-100, 107-129,186-208, 236-258 and 312-334 216596002013 Pfam match to entry PF02653.5 BPD_transp_2, score 234.0, E-value 2.7e-67 216596002014 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 216596002015 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 216596002016 Walker A/P-loop; other site 216596002017 ATP binding site [chemical binding]; other site 216596002018 Q-loop/lid; other site 216596002019 ABC transporter signature motif; other site 216596002020 Walker B; other site 216596002021 D-loop; other site 216596002022 H-loop/switch region; other site 216596002023 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 216596002024 Pfam match to entry PF00005.11 ABC_tran, score 104.3, E-value 2.9e-28 216596002025 Pfam match to entry PF00005.11 ABC_tran, score 196.0, E-value 7.2e-56 216596002026 Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; pfam10054 216596002027 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 216596002028 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 216596002029 ligand binding site [chemical binding]; other site 216596002030 dimerization interface [polypeptide binding]; other site 216596002031 Pfam match to entry PF00532.8 Peripla_BP_1, score 27.9, E-value 6.5e-06 216596002032 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 216596002033 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 216596002034 Pfam match to entry PF07005.1 DUF1537, score -90.9, E-value 0.00058 216596002035 Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850 216596002036 Ribulose bisphosphate carboxylase like proteins from nonphototrophic bacteria; Region: RLP_NonPhot; cd08207 216596002037 dimer interface [polypeptide binding]; other site 216596002038 active site 216596002039 catalytic residue [active] 216596002040 metal binding site [ion binding]; metal-binding site 216596002041 Pfam match to entry PF00016.8 RuBisCO_large, score 43.5, E-value 2.5e-12 216596002042 transcriptional regulator NanR; Provisional; Region: PRK03837 216596002043 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596002044 DNA-binding site [nucleotide binding]; DNA binding site 216596002045 FCD domain; Region: FCD; pfam07729 216596002046 Pfam match to entry PF00392.9 GntR, score 81.6,E-value 2.1e-21 216596002047 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 216596002048 Transcriptional regulators [Transcription]; Region: FadR; COG2186 216596002049 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596002050 DNA-binding site [nucleotide binding]; DNA binding site 216596002051 FCD domain; Region: FCD; pfam07729 216596002052 Pfam match to entry PF00392.9 GntR, score 97.6,E-value 3.2e-26 216596002053 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 216596002054 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 216596002055 Pfam match to entry PF03480.3 SBP_bac_7, score 236.5, E-value 4.7e-68 216596002056 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 216596002057 4 probable transmembrane helices predicted at aa 89-107, 117-139, 160-182 and 202-224 216596002058 Pfam match to entry PF04290.2 DctQ, score 85.3,E-value 1.6e-22 216596002059 DctM-like transporters; Region: DctM; pfam06808 216596002060 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 216596002061 13 probable transmembrane helices predicted at aa 10-32, 45-67, 71-87, 94-116,136-158, 165-187, 207-226, 231-253, 273-295, 316-338,353-384, 397-419 and 439-461 216596002062 Pfam match to entry PF06808.1 DctM, score 130.5,E-value 3.9e-36 216596002063 Pfam match to entry PF00597.8 DedA, score 23.6,E-value 2.9e-06 216596002064 Pfam match to entry PF00597.8 DedA, score 19.6,E-value 3.9e-05 216596002065 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 216596002066 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 216596002067 putative NAD(P) binding site [chemical binding]; other site 216596002068 catalytic Zn binding site [ion binding]; other site 216596002069 Pfam match to entry PF00107.11 ADH_zinc_N, score 272.1, E-value 9.2e-79 216596002070 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 216596002071 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 216596002072 Pfam match to entry PF01094.13 ANF_receptor, score 138.4, E-value 1.6e-38 216596002073 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596002074 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 216596002075 TM-ABC transporter signature motif; other site 216596002076 Pfam match to entry PF02653.5 BPD_transp_2, score 102.5, E-value 1.1e-27 216596002077 7 probable transmembrane helices predicted at aa 15-37, 58-80, 95-117, 142-164,194-216, 229-251 and 266-283 216596002078 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 216596002079 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 216596002080 TM-ABC transporter signature motif; other site 216596002081 9 probable transmembrane helices predicted at aa 17-34, 38-60, 65-87, 92-114,121-143, 172-191, 223-245, 260-282 and 295-317 216596002082 Pfam match to entry PF02653.5 BPD_transp_2, score 135.4, E-value 1.3e-37 216596002083 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 216596002084 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 216596002085 Walker A/P-loop; other site 216596002086 ATP binding site [chemical binding]; other site 216596002087 Q-loop/lid; other site 216596002088 ABC transporter signature motif; other site 216596002089 Walker B; other site 216596002090 D-loop; other site 216596002091 H-loop/switch region; other site 216596002092 Pfam match to entry PF00005.11 ABC_tran, score 172.0, E-value 1.3e-48 216596002093 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 216596002094 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 216596002095 Walker A/P-loop; other site 216596002096 ATP binding site [chemical binding]; other site 216596002097 Q-loop/lid; other site 216596002098 ABC transporter signature motif; other site 216596002099 Walker B; other site 216596002100 D-loop; other site 216596002101 H-loop/switch region; other site 216596002102 Pfam match to entry PF00005.11 ABC_tran, score 167.2, E-value 3.5e-47 216596002103 aspartate aminotransferase; Provisional; Region: PRK06107 216596002104 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216596002105 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596002106 homodimer interface [polypeptide binding]; other site 216596002107 catalytic residue [active] 216596002108 Pfam match to entry PF00155.8 Aminotran_1_2, score 230.4, E-value 3.4e-66 216596002109 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 216596002110 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596002111 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 216596002112 putative dimerization interface [polypeptide binding]; other site 216596002113 Pfam match to entry PF00126.10 HTH_1, score 67.8,E-value 2.8e-17 216596002114 Pfam match to entry PF03466.5 LysR_substrate, score 105.6, E-value 1.2e-28 216596002115 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 216596002116 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 216596002117 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 216596002118 Pfam match to entry PF05378.1 Hydant_A_N, score 216.3, E-value 5.9e-62 216596002119 Pfam match to entry PF01968.6 Hydantoinase_A, score 334.7, E-value 1.3e-97 216596002120 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 216596002121 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 216596002122 Pfam match to entry PF02538.4 Hydantoinase_B, score 198.5, E-value 1.3e-56 216596002123 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 216596002124 classical (c) SDRs; Region: SDR_c; cd05233 216596002125 NAD(P) binding site [chemical binding]; other site 216596002126 active site 216596002127 Pfam match to entry PF00106.11 adh_short, score 211.3, E-value 1.8e-60 216596002128 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 216596002129 Pfam match to entry PF03328.3 HpcH_HpaI, score 45.2, E-value 3.1e-12 216596002130 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 216596002131 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 216596002132 putative Zn2+ binding site [ion binding]; other site 216596002133 putative DNA binding site [nucleotide binding]; other site 216596002134 AsnC family; Region: AsnC_trans_reg; pfam01037 216596002135 Pfam match to entry PF01037.8 AsnC_trans_reg, score 143.9, E-value 3.6e-40 216596002136 Predicted helix-turn-helix motif with score 1488.000, SD 4.25 at aa 21-42, sequence MSNAKLAAEIGLSPSACLRRIK 216596002137 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 216596002138 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 216596002139 active site 216596002140 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 216596002141 dimer interface [polypeptide binding]; other site 216596002142 substrate binding site [chemical binding]; other site 216596002143 catalytic residues [active] 216596002144 Pfam match to entry PF01168.8 Ala_racemase_N, score 261.2, E-value 1.7e-75 216596002145 Pfam match to entry PF00842.8 Ala_racemase_C, score 221.9, E-value 1.2e-63 216596002146 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 216596002147 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 216596002148 hydroxyglutarate oxidase; Provisional; Region: PRK11728 216596002149 Pfam match to entry PF01266.8 DAO, score -64.7,E-value 0.00046 216596002150 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216596002151 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216596002152 Pfam match to entry PF00165.8 HTH_AraC, score 27.2, E-value 4.7e-05 216596002153 Predicted helix-turn-helix motif with score 1415.000, SD 4.01 at aa 270-291, sequence ISLNDIAIAAKVSVRTLQQGFR 216596002154 Pfam match to entry PF00165.8 HTH_AraC, score 34.6, E-value 2.9e-07 216596002155 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 216596002156 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 216596002157 inhibitor-cofactor binding pocket; inhibition site 216596002158 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596002159 catalytic residue [active] 216596002160 Pfam match to entry PF00202.8 Aminotran_3, score 423.6, E-value 2.2e-124 216596002161 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 216596002162 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216596002163 non-specific DNA binding site [nucleotide binding]; other site 216596002164 salt bridge; other site 216596002165 sequence-specific DNA binding site [nucleotide binding]; other site 216596002166 Cupin domain; Region: Cupin_2; pfam07883 216596002167 Pfam match to entry PF01381.9 HTH_3, score 54.7,E-value 2.6e-13 216596002168 Predicted helix-turn-helix motif with score 1868.000, SD 5.55 at aa 18-39, sequence LSQRELAKRTGVPNSTISLIES 216596002169 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06476 216596002170 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 216596002171 Pfam match to entry PF01089.8 P5CR, score 19.6,E-value 4e-11 216596002172 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 216596002173 TadE-like protein; Region: TadE; pfam07811 216596002174 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 216596002175 TadE-like protein; Region: TadE; pfam07811 216596002176 1 probable transmembrane helix predicted at aa 20-42 216596002177 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 216596002178 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 216596002179 Pfam match to entry PF02104.5 SURF1, score 15.9,E-value 3.6e-05 216596002180 1 probable transmembrane helix predicted at aa 39-61 216596002181 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 216596002182 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 216596002183 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 216596002184 putative active site [active] 216596002185 Pfam match to entry PF01380.9 SIS, score 16.7,E-value 0.001 216596002186 Pfam match to entry PF01418.7 HTH_6, score 24.0,E-value 7.9e-07 216596002187 Predicted helix-turn-helix motif with score 1611.000, SD 4.67 at aa 72-93, sequence YSAQELAALAHVSKATVTRFIQ 216596002188 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 216596002189 Pfam match to entry PF01177.8 Asp_Glu_race, score -19.5, E-value 0.0012 216596002190 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 216596002191 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596002192 Walker A/P-loop; other site 216596002193 ATP binding site [chemical binding]; other site 216596002194 Q-loop/lid; other site 216596002195 ABC transporter signature motif; other site 216596002196 Walker B; other site 216596002197 D-loop; other site 216596002198 H-loop/switch region; other site 216596002199 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216596002200 Pfam match to entry PF00005.11 ABC_tran, score 204.5, E-value 2.1e-58 216596002201 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 216596002202 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596002203 Walker A/P-loop; other site 216596002204 ATP binding site [chemical binding]; other site 216596002205 Q-loop/lid; other site 216596002206 ABC transporter signature motif; other site 216596002207 Walker B; other site 216596002208 D-loop; other site 216596002209 H-loop/switch region; other site 216596002210 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216596002211 Pfam match to entry PF00005.11 ABC_tran, score 224.8, E-value 1.5e-64 216596002212 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 216596002213 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596002214 putative PBP binding loops; other site 216596002215 dimer interface [polypeptide binding]; other site 216596002216 ABC-ATPase subunit interface; other site 216596002217 Pfam match to entry PF00528.10 BPD_transp_1, score 109.9, E-value 6e-30 216596002218 5 probable transmembrane helices predicted at aa 34-56, 104-126, 138-160,220-242 and 263-285 216596002219 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 216596002220 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596002221 dimer interface [polypeptide binding]; other site 216596002222 conserved gate region; other site 216596002223 putative PBP binding loops; other site 216596002224 ABC-ATPase subunit interface; other site 216596002225 Pfam match to entry PF00528.10 BPD_transp_1, score 174.7, E-value 1.9e-49 216596002226 6 probable transmembrane helices predicted at aa 9-31, 99-121, 142-164,179-201, 242-264 and 284-306 216596002227 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 216596002228 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_8; cd08495 216596002229 Pfam match to entry PF00496.9 SBP_bac_5, score 69.3, E-value 1e-17 216596002230 cggaccgaagcg 216596002231 submitted without /pseudo; similarity:fasta; SWALL:Q9A2R1 (EMBL:AE006008); Caulobacter crescentus; methlytransferase, ubie/coq5 family; length 276 aa; id=30.08; ungapped id=33.66; E()=1.3e-10; 226 aa overlap; query 4-212 aa; subject 57-275 aa; putative methyltransferase, pseudogene 216596002232 Transposase; Region: DEDD_Tnp_IS110; pfam01548 216596002233 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 216596002234 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 216596002235 Pfam match to entry PF02371.5 Transposase_20, score 87.8, E-value 2.7e-23 216596002236 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 216596002237 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 216596002238 putative active site [active] 216596002239 metal binding site [ion binding]; metal-binding site 216596002240 Pfam match to entry PF00465.7 Fe-ADH, score 321.5, E-value 1.2e-93 216596002241 Predicted amidohydrolase [General function prediction only]; Region: COG0388 216596002242 First nitrilase domain of an uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_1_R1; cd07578 216596002243 putative active site [active] 216596002244 catalytic triad [active] 216596002245 putative dimer interface [polypeptide binding]; other site 216596002246 nitrilase; Region: PLN02798 216596002247 Second nitrilase domain of an uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_1_R2; cd07579 216596002248 putative active site [active] 216596002249 catalytic triad [active] 216596002250 putative dimer interface [polypeptide binding]; other site 216596002251 Pfam match to entry PF00795.10 CN_hydrolase, score 111.7, E-value 1.8e-30 216596002252 Pfam match to entry PF00795.10 CN_hydrolase, score 121.9, E-value 1.6e-33 216596002253 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 216596002254 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 216596002255 Walker A/P-loop; other site 216596002256 ATP binding site [chemical binding]; other site 216596002257 Q-loop/lid; other site 216596002258 ABC transporter signature motif; other site 216596002259 Walker B; other site 216596002260 D-loop; other site 216596002261 H-loop/switch region; other site 216596002262 Pfam match to entry PF00005.11 ABC_tran, score 172.1, E-value 1.2e-48 216596002263 Uncharacterized ABC-type transport system, ATPase component [General function prediction only]; Region: COG4674 216596002264 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 216596002265 Walker A/P-loop; other site 216596002266 ATP binding site [chemical binding]; other site 216596002267 Q-loop/lid; other site 216596002268 ABC transporter signature motif; other site 216596002269 Walker B; other site 216596002270 D-loop; other site 216596002271 H-loop/switch region; other site 216596002272 Pfam match to entry PF00005.11 ABC_tran, score 132.5, E-value 9.4e-37 216596002273 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 216596002274 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 216596002275 TM-ABC transporter signature motif; other site 216596002276 8 probable transmembrane helices predicted at aa 10-32, 37-59, 125-147,154-172, 201-223, 248-270, 290-312 and 325-344 216596002277 Pfam match to entry PF02653.5 BPD_transp_2, score 111.9, E-value 1.6e-30 216596002278 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 216596002279 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596002280 TM-ABC transporter signature motif; other site 216596002281 8 probable transmembrane helices predicted at aa 4-26, 31-53, 58-77, 84-106,146-168, 197-219, 234-256 and 269-286 216596002282 Pfam match to entry PF02653.5 BPD_transp_2, score 120.7, E-value 3.5e-33 216596002283 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 216596002284 Type I periplasmic components of amide-binding protein (AmiC) and the active transport system for short-chain and urea (FmdDEF); Region: PBP1_AmiC_like; cd06331 216596002285 ligand binding site [chemical binding]; other site 216596002286 Pfam match to entry PF01094.13 ANF_receptor, score 1.2, E-value 0.00024 216596002287 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 216596002288 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 216596002289 ANTAR domain; Region: ANTAR; pfam03861 216596002290 Pfam match to entry PF03861.3 ANTAR, score 45.1,E-value 2e-10 216596002291 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 216596002292 Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357 216596002293 ligand binding site [chemical binding]; other site 216596002294 regulator interaction site; other site 216596002295 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216596002296 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216596002297 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216596002298 Pfam match to entry PF00165.8 HTH_AraC, score 43.8, E-value 4.9e-10 216596002299 Pfam match to entry PF00165.8 HTH_AraC, score 53.9, E-value 4.6e-13 216596002300 Predicted helix-turn-helix motif with score 1452.000, SD 4.13 at aa 218-239, sequence VSISDVAQVCNLSRGYFIRAFR 216596002301 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 216596002302 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216596002303 Pfam match to entry PF00165.8 HTH_AraC, score 29.8, E-value 7.9e-06 216596002304 Pfam match to entry PF00165.8 HTH_AraC, score 24.8, E-value 0.00026 216596002305 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 216596002306 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 216596002307 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 216596002308 Pfam match to entry PF00561.8 Abhydrolase_1, score 134.1, E-value 3.2e-37 216596002309 Transmembrane secretion effector; Region: MFS_3; pfam05977 216596002310 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596002311 putative substrate translocation pore; other site 216596002312 Pfam match to entry PF05977.2 DUF894, score 1031.1, E-value 0 216596002313 12 probable transmembrane helices predicted at aa 7-26, 52-74, 83-102, 112-134,147-169, 174-196, 228-250, 260-279, 291-310, 315-337,350-372 and 376-395 216596002314 Pfam match to entry PF07690.1 MFS_1, score 112.4,E-value 1.1e-30 216596002315 Pfam match to entry PF07681.1 DoxX, score 78.4,E-value 1.9e-20 216596002316 4 probable transmembrane helices predicted at aa 71-93, 113-132, 139-161 and 176-195 216596002317 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 216596002318 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 216596002319 active site 216596002320 Protein of unknown function (DUF1427); Region: DUF1427; cl01771 216596002321 Pfam match to entry PF07235.1 DUF1427, score 244.6, E-value 1.7e-70 216596002322 2 probable transmembrane helices predicted at aa 5-22 and 27-49 216596002323 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 216596002324 Isochorismatase family; Region: Isochorismatase; pfam00857 216596002325 catalytic triad [active] 216596002326 dimer interface [polypeptide binding]; other site 216596002327 conserved cis-peptide bond; other site 216596002328 Pfam match to entry PF00857.9 Isochorismatase, score -30.1, E-value 5.3e-05 216596002329 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 216596002330 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216596002331 Zn binding site [ion binding]; other site 216596002332 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 216596002333 Zn binding site [ion binding]; other site 216596002334 Pfam match to entry PF00903.11 Glyoxalase, score 65.5, E-value 1.4e-16 216596002335 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596002336 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596002337 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 216596002338 putative effector binding pocket; other site 216596002339 dimerization interface [polypeptide binding]; other site 216596002340 Pfam match to entry PF00126.10 HTH_1, score 72.7,E-value 9.7e-19 216596002341 Predicted helix-turn-helix motif with score 1754.000, SD 5.16 at aa 17-38, sequence RNFAQVARELDMTPAAVTRAIA 216596002342 Pfam match to entry PF03466.5 LysR_substrate, score 129.5, E-value 7.8e-36 216596002343 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 216596002344 Predicted outer membrane protein [Function unknown]; Region: COG3652 216596002345 Uncharacterized conserved protein [Function unknown]; Region: COG3189 216596002346 Pfam match to entry PF04343.2 DUF488, score 195.6, E-value 9.5e-56 216596002347 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 216596002348 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 216596002349 Pfam match to entry PF02563.5 Poly_export, score 67.8, E-value 2.9e-17 216596002350 Protein kinase domain; Region: Pkinase; pfam00069 216596002351 Catalytic domain of Protein Kinases; Region: PKc; cd00180 216596002352 active site 216596002353 ATP binding site [chemical binding]; other site 216596002354 substrate binding site [chemical binding]; other site 216596002355 activation loop (A-loop); other site 216596002356 Pfam match to entry PF00069.11 Pkinase, score 62.4, E-value 1.3e-15 216596002357 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867 216596002358 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 216596002359 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 216596002360 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 216596002361 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 216596002362 Pfam match to entry PF06744.1 DUF1215, score 200.9, E-value 2.5e-57 216596002363 Pfam match to entry PF06761.1 ImcF-related, score 375.9, E-value 5.1e-110 216596002364 3 probable transmembrane helices predicted at aa 20-42, 57-79 and 435-457 216596002365 hypothetical protein; Provisional; Region: PRK07033 216596002366 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 216596002367 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 216596002368 ligand binding site [chemical binding]; other site 216596002369 Pfam match to entry PF00691.7 OmpA, score 82.9,E-value 8.2e-22 216596002370 1 probable transmembrane helix predicted at aa 257-279 216596002371 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 216596002372 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 216596002373 Pfam match to entry PF05936.1 DUF876, score 915.4, E-value 2e-272 216596002374 Predicted component of the type VI protein secretion system, contains a FHA domain [Intracellular trafficking, secretion, and vesicular transport; Signal transduction mechanisms]; Region: COG3456 216596002375 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 216596002376 phosphopeptide binding site; other site 216596002377 Pfam match to entry PF00498.11 FHA, score 54.1,E-value 3.8e-13 216596002378 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 216596002379 Pfam match to entry PF06996.1 DUF1305, score 453.9, E-value 1.8e-133 216596002380 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 216596002381 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 216596002382 Pfam match to entry PF05947.1 DUF879, score 1105.4, E-value 0 216596002383 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3518 216596002384 Pfam match to entry PF07025.1 DUF1316, score 183.5, E-value 4.2e-52 216596002385 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 216596002386 ImpE protein; Region: ImpE; pfam07024 216596002387 Pfam match to entry PF07024.1 ImpE, score 502.0,E-value 5.7e-148 216596002388 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 216596002389 Protein of unknown function (DUF877); Region: DUF877; pfam05943 216596002390 Pfam match to entry PF05943.1 DUF877, score 383.8, E-value 2.2e-112 216596002391 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 216596002392 Protein of unknown function (DUF877); Region: DUF877; pfam05943 216596002393 Pfam match to entry PF05943.1 DUF877, score 1169.2, E-value 0 216596002394 Protein of unknown function (DUF770); Region: DUF770; pfam05591 216596002395 Pfam match to entry PF05591.1 DUF770, score 314.3, E-value 1.9e-91 216596002396 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 216596002397 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 216596002398 Pfam match to entry PF06812.1 ImpA-rel_N, score 86.7, E-value 6e-23 216596002399 similarity:fasta; SWALL:CLPB_ECOLI (SWALL:P63284); Escherichia coli; chaperone ClpB; clpB; length 857 aa; id=38.75; ungapped id=40.65; E()=3.5e-81; 836 aa overlap; query 34-858 aa; subject 37-844 aa; similarity:fasta; SWALL:Q9I742 (EMBL:AE004447); Pseudomonas aeruginosa; probable clpa/b-type chaperone; length 902 aa; id=47.38; ungapped id=49.01; E()=1.5e-122; 842 aa overlap; query 57-877 aa; subject 67-901 aa; putative chaperone ClpB, pseudogene 216596002400 Pfam match to entry PF00004.13 AAA, score 40.1,E-value 6.4e-09 216596002401 Protein of unknown function (DUF796); Region: DUF796; cl01226 216596002402 Pfam match to entry PF05638.1 DUF796, score 179.3, E-value 7.9e-51 216596002403 1 probable transmembrane helix predicted at aa 58-80 216596002404 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 216596002405 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 216596002406 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 216596002407 Pfam match to entry PF04524.2 DUF586, score 149.9, E-value 5.8e-42 216596002408 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212 216596002409 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 216596002410 GAD-like domain; Region: GAD-like; pfam08887 216596002411 Domain of unknown function (DUF1851); Region: DUF1851; pfam08906 216596002412 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 216596002413 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 216596002414 NAD(P) binding site [chemical binding]; other site 216596002415 catalytic residues [active] 216596002416 Pfam match to entry PF00171.9 Aldedh, score 491.1, E-value 1.1e-144 216596002417 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 216596002418 alpha hydroxysteroid dehydrogenase (3alpha_HSD), classical (c) SDRs; Region: 3alpha_HSD_SDR_c; cd05328 216596002419 NAD binding site [chemical binding]; other site 216596002420 active site 216596002421 homodimer interface [polypeptide binding]; other site 216596002422 Pfam match to entry PF00106.11 adh_short, score 91.1, E-value 2.9e-24 216596002423 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 216596002424 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 216596002425 TM-ABC transporter signature motif; other site 216596002426 7 probable transmembrane helices predicted at aa 21-43, 53-75, 96-118, 171-190,222-244, 259-281 and 288-310 216596002427 Pfam match to entry PF02653.5 BPD_transp_2, score 13.9, E-value 4.9e-05 216596002428 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596002429 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 216596002430 TM-ABC transporter signature motif; other site 216596002431 8 probable transmembrane helices predicted at aa 4-26, 31-50, 54-76, 89-108,141-163, 192-214, 229-251 and 258-280 216596002432 Pfam match to entry PF02653.5 BPD_transp_2, score 49.2, E-value 1.2e-11 216596002433 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 216596002434 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 216596002435 Walker A/P-loop; other site 216596002436 ATP binding site [chemical binding]; other site 216596002437 Q-loop/lid; other site 216596002438 ABC transporter signature motif; other site 216596002439 Walker B; other site 216596002440 D-loop; other site 216596002441 H-loop/switch region; other site 216596002442 Pfam match to entry PF00005.11 ABC_tran, score 170.7, E-value 3.2e-48 216596002443 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 216596002444 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 216596002445 Walker A/P-loop; other site 216596002446 ATP binding site [chemical binding]; other site 216596002447 Q-loop/lid; other site 216596002448 ABC transporter signature motif; other site 216596002449 Walker B; other site 216596002450 D-loop; other site 216596002451 H-loop/switch region; other site 216596002452 Pfam match to entry PF00005.11 ABC_tran, score 114.4, E-value 2.8e-31 216596002453 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 216596002454 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_4; cd06337 216596002455 putative ligand binding site [chemical binding]; other site 216596002456 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 216596002457 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 216596002458 NAD(P) binding site [chemical binding]; other site 216596002459 catalytic residues [active] 216596002460 Pfam match to entry PF00171.9 Aldedh, score 511.5, E-value 7.7e-151 216596002461 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 216596002462 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216596002463 Pfam match to entry PF00165.8 HTH_AraC, score 16.5, E-value 0.041 216596002464 Pfam match to entry PF00165.8 HTH_AraC, score 33.0, E-value 8.6e-07 216596002465 1 probable transmembrane helix predicted at aa 15-37 216596002466 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 216596002467 DctM-like transporters; Region: DctM; pfam06808 216596002468 12 probable transmembrane helices predicted at aa 10-41, 92-111, 131-160,173-195, 210-232, 253-275, 285-303, 323-345, 355-372,379-396, 401-423 and 444-466 216596002469 Pfam match to entry PF00597.8 DedA, score 26.5,E-value 4.5e-07 216596002470 Pfam match to entry PF06808.1 DctM, score 34.2,E-value 3.8e-07 216596002471 Signal peptide predicted for pRL120498 by SignalP 2.0 HMM (Signal peptide probabilty 0.972) with cleavage site probability 0.565 between residues 30 and 31 216596002472 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 216596002473 Pfam match to entry PF04290.2 DctQ, score 44.5,E-value 3e-10 216596002474 4 probable transmembrane helices predicted at aa 13-35, 50-68, 89-111 and 131-153 216596002475 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 216596002476 Pfam match to entry PF03480.3 SBP_bac_7, score 71.3, E-value 2.5e-18 216596002477 1 probable transmembrane helix predicted at aa 11-33 216596002478 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 216596002479 cyclase homology domain; Region: CHD; cd07302 216596002480 nucleotidyl binding site; other site 216596002481 metal binding site [ion binding]; metal-binding site 216596002482 dimer interface [polypeptide binding]; other site 216596002483 Pfam match to entry PF00211.9 Guanylate_cyc, score 40.7, E-value 1.4e-10 216596002484 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 216596002485 MarR family; Region: MarR_2; pfam12802 216596002486 Pfam match to entry PF01047.8 MarR, score 70.6,E-value 4.2e-18 216596002487 acyl-CoA synthetase; Validated; Region: PRK09088 216596002488 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 216596002489 acyl-activating enzyme (AAE) consensus motif; other site 216596002490 AMP binding site [chemical binding]; other site 216596002491 active site 216596002492 CoA binding site [chemical binding]; other site 216596002493 Pfam match to entry PF00501.11 AMP-binding, score 402.8, E-value 4e-118 216596002494 p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120 216596002495 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216596002496 substrate binding site [chemical binding]; other site 216596002497 oxyanion hole (OAH) forming residues; other site 216596002498 trimer interface [polypeptide binding]; other site 216596002499 Pfam match to entry PF00378.8 ECH, score 128.0,E-value 2.1e-35 216596002500 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 216596002501 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 216596002502 catalytic Zn binding site [ion binding]; other site 216596002503 NAD binding site [chemical binding]; other site 216596002504 structural Zn binding site [ion binding]; other site 216596002505 Pfam match to entry PF00107.11 ADH_zinc_N, score 357.1, E-value 2.4e-104 216596002506 1 probable transmembrane helix predicted at aa 188-210 216596002507 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 216596002508 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 216596002509 NAD(P) binding site [chemical binding]; other site 216596002510 catalytic residues [active] 216596002511 Pfam match to entry PF00171.9 Aldedh, score 123.5, E-value 4.8e-34 216596002512 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 216596002513 PAS fold; Region: PAS_4; pfam08448 216596002514 PAS fold; Region: PAS_7; pfam12860 216596002515 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 216596002516 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216596002517 metal binding site [ion binding]; metal-binding site 216596002518 active site 216596002519 I-site; other site 216596002520 6 probable transmembrane helices predicted at aa 18-40, 53-71, 86-108, 121-138,148-170 and 175-197 216596002521 Pfam match to entry PF00785.11 PAC, score 21.1,E-value 4.1e-05 216596002522 Pfam match to entry PF00990.8 GGDEF, score 225.7,E-value 8.8e-65 216596002523 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 216596002524 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 216596002525 putative molybdopterin cofactor binding site [chemical binding]; other site 216596002526 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 216596002527 putative molybdopterin cofactor binding site; other site 216596002528 Pfam match to entry PF00384.9 Molybdopterin, score 3.7, E-value 1.6e-08 216596002529 Pfam match to entry PF01568.7 Molydop_binding, score 19.5, E-value 5e-05 216596002530 Helix-turn-helix domain; Region: HTH_18; pfam12833 216596002531 Pfam match to entry PF00165.8 HTH_AraC, score 21.0, E-value 0.0036 216596002532 Pfam match to entry PF00165.8 HTH_AraC, score 29.6, E-value 9.5e-06 216596002533 Predicted helix-turn-helix motif with score 1013.000, SD 2.64 at aa 243-264, sequence ITMPKVAEAAGVSSRALETGFR 216596002534 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 216596002535 Pfam match to entry PF02615.4 Ldh_2, score 57.4,E-value 2.6e-14 216596002536 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216596002537 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 216596002538 Walker A/P-loop; other site 216596002539 ATP binding site [chemical binding]; other site 216596002540 Q-loop/lid; other site 216596002541 ABC transporter signature motif; other site 216596002542 Walker B; other site 216596002543 D-loop; other site 216596002544 H-loop/switch region; other site 216596002545 Pfam match to entry PF00005.11 ABC_tran, score 216.2, E-value 6.2e-62 216596002546 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 216596002547 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596002548 dimer interface [polypeptide binding]; other site 216596002549 conserved gate region; other site 216596002550 putative PBP binding loops; other site 216596002551 ABC-ATPase subunit interface; other site 216596002552 Pfam match to entry PF00528.10 BPD_transp_1, score 116.7, E-value 5.5e-32 216596002553 5 probable transmembrane helices predicted at aa 79-101, 111-133, 154-176,225-247 and 260-282 216596002554 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 216596002555 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 216596002556 Pfam match to entry PF04069.2 OpuAC, score 144.3,E-value 2.7e-40 216596002557 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 216596002558 Pfam match to entry PF01089.8 P5CR, score 121.4,E-value 2.1e-33 216596002559 1 probable transmembrane helix predicted at aa 7-29 216596002560 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216596002561 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216596002562 Pfam match to entry PF00440.8 TetR_N, score 24.8,E-value 0.00017 216596002563 Predicted helix-turn-helix motif with score 1224.000, SD 3.36 at aa 33-54, sequence VKILPLAKKLNLSRTSFYWFFK 216596002564 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 216596002565 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 216596002566 putative active site [active] 216596002567 putative FMN binding site [chemical binding]; other site 216596002568 putative substrate binding site [chemical binding]; other site 216596002569 putative catalytic residue [active] 216596002570 Pfam match to entry PF00724.7 Oxidored_FMN, score 147.5, E-value 2.9e-41 216596002571 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 216596002572 Ligand binding site [chemical binding]; other site 216596002573 Electron transfer flavoprotein domain; Region: ETF; pfam01012 216596002574 Pfam match to entry PF01012.9 ETF_beta, score 428.7, E-value 6.8e-126 216596002575 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 216596002576 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 216596002577 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 216596002578 Pfam match to entry PF00766.8 ETF_alpha, score 408.6, E-value 7.6e-120 216596002579 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 216596002580 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 216596002581 substrate binding site [chemical binding]; other site 216596002582 catalytic Zn binding site [ion binding]; other site 216596002583 NAD binding site [chemical binding]; other site 216596002584 structural Zn binding site [ion binding]; other site 216596002585 dimer interface [polypeptide binding]; other site 216596002586 Pfam match to entry PF00107.11 ADH_zinc_N, score 434.4, E-value 1.3e-127 216596002587 S-formylglutathione hydrolase; Region: PLN02442 216596002588 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 216596002589 Pfam match to entry PF00756.9 Esterase, score 239.6, E-value 5.5e-69 216596002590 glutathione-dependent formaldehyde-activating enzyme; Provisional; Region: PRK05417 216596002591 Pfam match to entry PF04828.3 DUF636, score 64.3,E-value 3.4e-16 216596002592 Transcriptional regulators [Transcription]; Region: GntR; COG1802 216596002593 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596002594 DNA-binding site [nucleotide binding]; DNA binding site 216596002595 FCD domain; Region: FCD; pfam07729 216596002596 Pfam match to entry PF00392.9 GntR, score 47.5,E-value 3.8e-11 216596002597 Predicted helix-turn-helix motif with score 995.000, SD 2.58 at aa 28-49, sequence LDEASLSEKYGLSRTPVRDIFR 216596002598 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 216596002599 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 216596002600 inhibitor site; inhibition site 216596002601 active site 216596002602 dimer interface [polypeptide binding]; other site 216596002603 catalytic residue [active] 216596002604 Pfam match to entry PF00701.10 DHDPS, score 185.4, E-value 1.1e-52 216596002605 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 216596002606 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 216596002607 NAD(P) binding site [chemical binding]; other site 216596002608 catalytic residues [active] 216596002609 Pfam match to entry PF00171.9 Aldedh, score 691.2, E-value 6.2e-205 216596002610 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 216596002611 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 216596002612 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 216596002613 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 216596002614 Pfam match to entry PF04069.2 OpuAC, score 168.7,E-value 1.3e-47 216596002615 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 216596002616 choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415 216596002617 Walker A/P-loop; other site 216596002618 ATP binding site [chemical binding]; other site 216596002619 Q-loop/lid; other site 216596002620 ABC transporter signature motif; other site 216596002621 Walker B; other site 216596002622 D-loop; other site 216596002623 H-loop/switch region; other site 216596002624 Pfam match to entry PF00005.11 ABC_tran, score 235.3, E-value 1.1e-67 216596002625 Pfam match to entry PF00571.14 CBS, score 18.7,E-value 0.00027 216596002626 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596002627 dimer interface [polypeptide binding]; other site 216596002628 conserved gate region; other site 216596002629 putative PBP binding loops; other site 216596002630 ABC-ATPase subunit interface; other site 216596002631 6 probable transmembrane helices predicted at aa 42-64, 66-88, 98-120, 141-163,214-236 and 249-266 216596002632 Pfam match to entry PF00528.10 BPD_transp_1, score 88.3, E-value 2e-23 216596002633 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596002634 dimer interface [polypeptide binding]; other site 216596002635 conserved gate region; other site 216596002636 ABC-ATPase subunit interface; other site 216596002637 6 probable transmembrane helices predicted at aa 45-67, 72-91, 95-117, 139-161,218-237 and 250-269 216596002638 Pfam match to entry PF00528.10 BPD_transp_1, score 77.2, E-value 4.3e-20 216596002639 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 216596002640 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 216596002641 Pfam match to entry PF05544.1 Pro_racemase, score 610.9, E-value 9.5e-181 216596002642 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 216596002643 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 216596002644 conserved cys residue [active] 216596002645 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216596002646 1 probable transmembrane helix predicted at aa 21-38 216596002647 Pfam match to entry PF01965.10 DJ-1_PfpI, score 12.6, E-value 0.00014 216596002648 Pfam match to entry PF00165.8 HTH_AraC, score 14.2, E-value 0.076 216596002649 Predicted helix-turn-helix motif with score 1723.000, SD 5.06 at aa 248-269, sequence MSIQKLAATVGLSRRQLERIFI 216596002650 Pfam match to entry PF00165.8 HTH_AraC, score 45.5, E-value 1.5e-10 216596002651 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 216596002652 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 216596002653 FAD binding pocket [chemical binding]; other site 216596002654 FAD binding motif [chemical binding]; other site 216596002655 phosphate binding motif [ion binding]; other site 216596002656 beta-alpha-beta structure motif; other site 216596002657 NAD binding pocket [chemical binding]; other site 216596002658 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 216596002659 catalytic loop [active] 216596002660 iron binding site [ion binding]; other site 216596002661 Pfam match to entry PF00111.12 Fer2, score 65.1,E-value 1.9e-16 216596002662 Pfam match to entry PF00175.8 NAD_binding_1, score 57.6, E-value 3.3e-14 216596002663 Pfam match to entry PF00970.9 FAD_binding_6, score 80.1, E-value 5.7e-21 216596002664 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 216596002665 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 216596002666 [2Fe-2S] cluster binding site [ion binding]; other site 216596002667 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 216596002668 putative alpha subunit interface [polypeptide binding]; other site 216596002669 putative active site [active] 216596002670 putative substrate binding site [chemical binding]; other site 216596002671 Fe binding site [ion binding]; other site 216596002672 Pfam match to entry PF00355.13 Rieske, score 91.8, E-value 1.7e-24 216596002673 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 216596002674 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596002675 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216596002676 dimerization interface [polypeptide binding]; other site 216596002677 Pfam match to entry PF00126.10 HTH_1, score 70.9,E-value 3.4e-18 216596002678 Predicted helix-turn-helix motif with score 1695.000, SD 4.96 at aa 24-45, sequence KSFTTAATELGVTQAAVSRQIA 216596002679 Pfam match to entry PF03466.5 LysR_substrate, score 107.5, E-value 3.2e-29 216596002680 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 216596002681 putative trimer interface [polypeptide binding]; other site 216596002682 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 216596002683 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 216596002684 trimer interface [polypeptide binding]; other site 216596002685 active site 216596002686 substrate binding site [chemical binding]; other site 216596002687 putative CoA binding site [chemical binding]; other site 216596002688 CoA binding site [chemical binding]; other site 216596002689 Pfam match to entry PF00132.9 Hexapep, score 15.0, E-value 0.22 216596002690 Pfam match to entry PF00132.9 Hexapep, score 17.1, E-value 0.054 216596002691 Pfam match to entry PF00132.9 Hexapep, score 6.3,E-value 21 216596002692 Pfam match to entry PF00132.9 Hexapep, score 14.4, E-value 0.34 216596002693 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 216596002694 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216596002695 metal binding site [ion binding]; metal-binding site 216596002696 active site 216596002697 I-site; other site 216596002698 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216596002699 Pfam match to entry PF00563.9 EAL, score 260.2,E-value 3.5e-75 216596002700 Pfam match to entry PF00990.8 GGDEF, score 207.6,E-value 2.4e-59 216596002701 5 probable transmembrane helices predicted at aa 58-77, 81-103, 110-132,137-159 and 164-186 216596002702 Methyltransferase domain; Region: Methyltransf_25; pfam13649 216596002703 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216596002704 NmrA-like family; Region: NmrA; pfam05368 216596002705 NAD(P) binding site [chemical binding]; other site 216596002706 active site 216596002707 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596002708 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596002709 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 216596002710 putative effector binding pocket; other site 216596002711 dimerization interface [polypeptide binding]; other site 216596002712 Pfam match to entry PF00126.10 HTH_1, score 75.0,E-value 1.9e-19 216596002713 Predicted helix-turn-helix motif with score 1637.000, SD 4.76 at aa 20-41, sequence GSFARAAELMGLSASGVSRAIS 216596002714 Pfam match to entry PF03466.5 LysR_substrate, score 154.0, E-value 3.4e-43 216596002715 Uncharacterized conserved protein [Function unknown]; Region: COG4925 216596002716 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 216596002717 clavulanic acid dehydrogenase (CAD), classical (c) SDR; Region: CAD_SDR_c; cd08934 216596002718 NADP binding site [chemical binding]; other site 216596002719 homotetramer interface [polypeptide binding]; other site 216596002720 homodimer interface [polypeptide binding]; other site 216596002721 active site 216596002722 Pfam match to entry PF00106.11 adh_short, score 244.9, E-value 1.4e-70 216596002723 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 216596002724 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596002725 12 probable transmembrane helices predicted at aa 21-43, 58-80, 87-109, 113-135,147-169, 174-196, 217-239, 254-276, 281-303, 313-335,342-364 and 368-390 216596002726 Pfam match to entry PF07690.1 MFS_1, score 150.0,E-value 5.3e-42 216596002727 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596002728 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596002729 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 216596002730 putative effector binding pocket; other site 216596002731 putative dimerization interface [polypeptide binding]; other site 216596002732 Pfam match to entry PF00126.10 HTH_1, score 72.1,E-value 1.4e-18 216596002733 Predicted helix-turn-helix motif with score 1664.000, SD 4.85 at aa 19-40, sequence RSFTRAASKLGVTRSALSHTIS 216596002734 Pfam match to entry PF03466.5 LysR_substrate, score 153.7, E-value 4e-43 216596002735 classical (c) SDRs; Region: SDR_c; cd05233 216596002736 active site 216596002737 Pfam match to entry PF00106.11 adh_short, score 16.9, E-value 1.6e-07 216596002738 DoxX-like family; Region: DoxX_2; pfam13564 216596002739 4 probable transmembrane helices predicted at aa 5-27, 40-62, 72-91 and 96-113 216596002740 Predicted transcriptional regulators [Transcription]; Region: COG1733 216596002741 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 216596002742 Pfam match to entry PF01638.6 DUF24, score 112.1,E-value 1.3e-30 216596002743 Predicted helix-turn-helix motif with score 1005.000, SD 2.61 at aa 73-94, sequence YEITQKARGLGPTMEALTAWWN 216596002744 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 216596002745 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216596002746 putative DNA binding site [nucleotide binding]; other site 216596002747 dimerization interface [polypeptide binding]; other site 216596002748 putative Zn2+ binding site [ion binding]; other site 216596002749 AsnC family; Region: AsnC_trans_reg; pfam01037 216596002750 Pfam match to entry PF01037.8 AsnC_trans_reg, score 159.2, E-value 9e-45 216596002751 Predicted helix-turn-helix motif with score 1434.000, SD 4.07 at aa 28-49, sequence LSITDLAARVGLSKTPCQIRFK 216596002752 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 216596002753 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 216596002754 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 216596002755 Glutamate binding site [chemical binding]; other site 216596002756 NAD binding site [chemical binding]; other site 216596002757 catalytic residues [active] 216596002758 Pfam match to entry PF01619.6 Pro_dh, score 558.4, E-value 6.1e-165 216596002759 Pfam match to entry PF00171.9 Aldedh, score 234.4, E-value 2e-67 216596002760 Transcriptional regulators [Transcription]; Region: PurR; COG1609 216596002761 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216596002762 DNA binding site [nucleotide binding] 216596002763 domain linker motif; other site 216596002764 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 216596002765 putative dimerization interface [polypeptide binding]; other site 216596002766 putative ligand binding site [chemical binding]; other site 216596002767 Pfam match to entry PF00356.8 LacI, score 29.9,E-value 7.5e-06 216596002768 Predicted helix-turn-helix motif with score 1694.000, SD 4.96 at aa 105-126, sequence VSLSDIAERAGVSVKTVSGALH 216596002769 Pfam match to entry PF00532.8 Peripla_BP_1, score 36.5, E-value 7.9e-08 216596002770 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 216596002771 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 216596002772 Pfam match to entry PF01547.11 SBP_bac_1, score 67.5, E-value 3.7e-17 216596002773 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596002774 dimer interface [polypeptide binding]; other site 216596002775 conserved gate region; other site 216596002776 putative PBP binding loops; other site 216596002777 ABC-ATPase subunit interface; other site 216596002778 5 probable transmembrane helices predicted at aa 30-52, 89-111, 124-146,177-199 and 280-302 216596002779 Pfam match to entry PF00528.10 BPD_transp_1, score 55.0, E-value 2.1e-13 216596002780 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216596002781 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596002782 dimer interface [polypeptide binding]; other site 216596002783 conserved gate region; other site 216596002784 putative PBP binding loops; other site 216596002785 ABC-ATPase subunit interface; other site 216596002786 6 probable transmembrane helices predicted at aa 25-47, 99-121, 128-150,160-182, 203-225 and 264-286 216596002787 Pfam match to entry PF00528.10 BPD_transp_1, score 58.2, E-value 2.2e-14 216596002788 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 216596002789 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 216596002790 substrate binding [chemical binding]; other site 216596002791 active site 216596002792 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 216596002793 Pfam match to entry PF00251.8 Glyco_hydro_32, score 166.0, E-value 7.8e-47 216596002794 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 216596002795 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 216596002796 Walker A/P-loop; other site 216596002797 ATP binding site [chemical binding]; other site 216596002798 Q-loop/lid; other site 216596002799 ABC transporter signature motif; other site 216596002800 Walker B; other site 216596002801 D-loop; other site 216596002802 H-loop/switch region; other site 216596002803 TOBE domain; Region: TOBE_2; pfam08402 216596002804 Pfam match to entry PF00005.11 ABC_tran, score 223.8, E-value 3.2e-64 216596002805 Pfam match to entry PF03459.4 TOBE, score 44.6,E-value 2.8e-10 216596002806 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12854 216596002807 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 216596002808 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 216596002809 Pfam match to entry PF02781.4 G6PD_C, score 299.9, E-value 4e-87 216596002810 Pfam match to entry PF00479.8 G6PD_N, score 156.8, E-value 4.7e-44 216596002811 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 216596002812 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216596002813 non-specific DNA binding site [nucleotide binding]; other site 216596002814 salt bridge; other site 216596002815 sequence-specific DNA binding site [nucleotide binding]; other site 216596002816 Pfam match to entry PF01381 HTH_3, score 52.00,E-value 1.2e-12 216596002817 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596002818 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596002819 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 216596002820 dimerization interface [polypeptide binding]; other site 216596002821 substrate binding pocket [chemical binding]; other site 216596002822 Pfam match to entry PF00126.10 HTH_1, score 79.6,E-value 8.1e-21 216596002823 Predicted helix-turn-helix motif with score 1057.000, SD 2.79 at aa 16-37, sequence LHFGRAAAKVRIAQPALSNHVQ 216596002824 Pfam match to entry PF03466.5 LysR_substrate, score 129.0, E-value 1.1e-35 216596002825 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 216596002826 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 216596002827 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 216596002828 Pfam match to entry PF05406.2 WGR, score 101.5,E-value 2.1e-27 216596002829 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 216596002830 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 216596002831 Walker A motif; other site 216596002832 ATP binding site [chemical binding]; other site 216596002833 Walker B motif; other site 216596002834 Pfam match to entry PF02534.4 TraG, score 231.6,E-value 1.4e-66 216596002835 3 probable transmembrane helices predicted at aa 13-35, 45-67 and 74-96 216596002836 RNA pol II promoter Fmp27 protein domain; Region: Fmp27_WPPW; pfam10359 216596002837 Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768 216596002838 MobA/MobL family; Region: MobA_MobL; pfam03389 216596002839 AAA domain; Region: AAA_30; pfam13604 216596002840 Family description; Region: UvrD_C_2; pfam13538 216596002841 Pfam match to entry PF03389.3 MobA_MobL, score 220.2, E-value 3.9e-63 216596002842 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216596002843 C factor cell-cell signaling protein; Provisional; Region: PRK09009 216596002844 NAD(P) binding site [chemical binding]; other site 216596002845 active site 216596002846 Pfam match to entry PF00106.11 adh_short, score 6.8, E-value 6.3e-07 216596002847 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 216596002848 GTP cyclohydrolase I; Provisional; Region: PLN03044 216596002849 active site 216596002850 Pfam match to entry PF01227.10 GTP_cyclohydroI, score 160.4, E-value 4e-45 216596002851 TspO/MBR family; Region: TspO_MBR; pfam03073 216596002852 5 probable transmembrane helices predicted at aa 13-35, 50-72, 79-98, 102-124 and 131-153 216596002853 Pfam match to entry PF03073.5 TspO_MBR, score 97.2, E-value 4e-26 216596002854 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 216596002855 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 216596002856 5 probable transmembrane helices predicted at aa 15-37, 42-61, 87-109, 121-143 and 147-169 216596002857 Predicted helix-turn-helix motif with score 1189.000, SD 3.24 at aa 142-163, sequence WTQTDLAILLNLNAFAVASLMA 216596002858 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 216596002859 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596002860 S-adenosylmethionine binding site [chemical binding]; other site 216596002861 Pfam match to entry PF02353.6 CMAS, score -37.5,E-value 2e-06 216596002862 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 216596002863 Pfam match to entry PF06966.1 DUF1295, score 312.2, E-value 7.9e-91 216596002864 5 probable transmembrane helices predicted at aa 20-42, 52-71, 122-144, 157-179 and 207-229 216596002865 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 216596002866 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 216596002867 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 216596002868 Pfam match to entry PF01593.9 Amino_oxidase, score 50.5, E-value 3e-14 216596002869 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 216596002870 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4731 216596002871 Predicted membrane protein (DUF2177); Region: DUF2177; pfam09945 216596002872 4 probable transmembrane helices predicted at aa 7-29, 49-68, 73-95 and 110-132 216596002873 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 216596002874 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216596002875 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 216596002876 DNA binding residues [nucleotide binding] 216596002877 Pfam match to entry PF04542.2 Sigma70_r2, score 72.7, E-value 9.8e-19 216596002878 Pfam match to entry PF04545.3 Sigma70_r4, score 52.8, E-value 9.3e-13 216596002879 Predicted helix-turn-helix motif with score 1298.000, SD 3.61 at aa 188-209, sequence LTHTMIAERLNLPLGTVKSRIR 216596002880 anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451 216596002881 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 216596002882 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216596002883 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216596002884 Pfam match to entry PF00440.8 TetR_N, score 24.4,E-value 2.3e-06 216596002885 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 216596002886 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 216596002887 DNA interaction; other site 216596002888 Metal-binding active site; metal-binding site 216596002889 Pfam match to entry PF01261.10 AP_endonuc_2, score 41.6, E-value 2.2e-09 216596002890 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 216596002891 Pfam match to entry PF01261.10 AP_endonuc_2, score 142.8, E-value 7.6e-40 216596002892 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 216596002893 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 216596002894 active site pocket [active] 216596002895 Pfam match to entry PF02746.4 MR_MLE_N, score 70.8, E-value 3.7e-18 216596002896 Pfam match to entry PF01188.9 MR_MLE, score 87.4,E-value 3.8e-23 216596002897 Transcriptional regulators [Transcription]; Region: FadR; COG2186 216596002898 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596002899 DNA-binding site [nucleotide binding]; DNA binding site 216596002900 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 216596002901 Pfam match to entry PF00392.9 GntR, score 29.4,E-value 1e-05 216596002902 Predicted helix-turn-helix motif with score 1545.000, SD 4.45 at aa 27-48, sequence PSERELAEHFGVSRGQIREALA 216596002903 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 216596002904 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 216596002905 ligand binding site [chemical binding]; other site 216596002906 NAD binding site [chemical binding]; other site 216596002907 dimerization interface [polypeptide binding]; other site 216596002908 catalytic site [active] 216596002909 Pfam match to entry PF00389.15 2-Hacid_dh, score 72.2, E-value 1.4e-18 216596002910 Pfam match to entry PF02826.5 2-Hacid_dh_C, score 221.8, E-value 1.2e-63 216596002911 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 216596002912 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 216596002913 Walker A/P-loop; other site 216596002914 ATP binding site [chemical binding]; other site 216596002915 Q-loop/lid; other site 216596002916 ABC transporter signature motif; other site 216596002917 Walker B; other site 216596002918 D-loop; other site 216596002919 H-loop/switch region; other site 216596002920 TOBE domain; Region: TOBE_2; pfam08402 216596002921 Pfam match to entry PF03459.4 TOBE, score 40.0,E-value 6.8e-09 216596002922 Pfam match to entry PF00005.11 ABC_tran, score 192.1, E-value 1.1e-54 216596002923 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 216596002924 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 216596002925 Walker A/P-loop; other site 216596002926 ATP binding site [chemical binding]; other site 216596002927 Q-loop/lid; other site 216596002928 ABC transporter signature motif; other site 216596002929 Walker B; other site 216596002930 D-loop; other site 216596002931 H-loop/switch region; other site 216596002932 TOBE domain; Region: TOBE_2; pfam08402 216596002933 Pfam match to entry PF03459.4 TOBE, score 45.0,E-value 2.2e-10 216596002934 Pfam match to entry PF00005.11 ABC_tran, score 199.9, E-value 5e-57 216596002935 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216596002936 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596002937 dimer interface [polypeptide binding]; other site 216596002938 conserved gate region; other site 216596002939 putative PBP binding loops; other site 216596002940 ABC-ATPase subunit interface; other site 216596002941 Pfam match to entry PF00528.10 BPD_transp_1, score 76.0, E-value 1e-19 216596002942 6 probable transmembrane helices predicted at aa 12-34, 117-139, 151-173,183-200, 230-252 and 283-305 216596002943 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 216596002944 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596002945 conserved gate region; other site 216596002946 dimer interface [polypeptide binding]; other site 216596002947 putative PBP binding loops; other site 216596002948 ABC-ATPase subunit interface; other site 216596002949 Pfam match to entry PF00528.10 BPD_transp_1, score 48.1, E-value 2.5e-11 216596002950 6 probable transmembrane helices predicted at aa 28-50, 81-103, 116-138,169-191, 212-234 and 273-295 216596002951 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 216596002952 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 216596002953 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 216596002954 Pfam match to entry PF01547.11 SBP_bac_1, score 77.5, E-value 3.5e-20 216596002955 Pfam match to entry PF00440.8 TetR_N, score 36.6,E-value 7.2e-08 216596002956 Predicted helix-turn-helix motif with score 1566.000, SD 4.52 at aa 47-68, sequence PSVSEVAEAAEVSRATAYRYFP 216596002957 Uncharacterized conserved protein [Function unknown]; Region: COG5441; cl02262 216596002958 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 216596002959 Pfam match to entry PF06792.1 UPF0261, score 961.0, E-value 3.8e-286 216596002960 1 probable transmembrane helix predicted at aa 90-109 216596002961 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 216596002962 Cupin domain; Region: Cupin_2; pfam07883 216596002963 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 216596002964 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 216596002965 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 216596002966 active site 216596002967 Pfam match to entry PF00557.9 Peptidase_M24, score 2.1, E-value 3e-07 216596002968 intracellular protease, PfpI family; Region: PfpI; TIGR01382 216596002969 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 216596002970 conserved cys residue [active] 216596002971 Pfam match to entry PF01965.10 DJ-1_PfpI, score 107.0, E-value 4.6e-29 216596002972 Transcriptional regulators [Transcription]; Region: GntR; COG1802 216596002973 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596002974 DNA-binding site [nucleotide binding]; DNA binding site 216596002975 FCD domain; Region: FCD; pfam07729 216596002976 Pfam match to entry PF00392.9 GntR, score 55.4,E-value 1.6e-13 216596002977 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 216596002978 Pfam match to entry PF02615.4 Ldh_2, score 268.6,E-value 1e-77 216596002979 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 216596002980 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 216596002981 active site 216596002982 NAD binding site [chemical binding]; other site 216596002983 metal binding site [ion binding]; metal-binding site 216596002984 Pfam match to entry PF00465.7 Fe-ADH, score 234.9, E-value 1.5e-67 216596002985 succinic semialdehyde dehydrogenase; Region: PLN02278 216596002986 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 216596002987 tetramerization interface [polypeptide binding]; other site 216596002988 NAD(P) binding site [chemical binding]; other site 216596002989 catalytic residues [active] 216596002990 Pfam match to entry PF00171.9 Aldedh, score 641.6, E-value 5.6e-190 216596002991 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 216596002992 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 216596002993 nucleophilic elbow; other site 216596002994 catalytic triad; other site 216596002995 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 216596002996 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 216596002997 Pfam match to entry PF01266.8 DAO, score -65.5,E-value 0.0005 216596002998 Predicted helix-turn-helix motif with score 991.000, SD 2.56 at aa 115-136, sequence ARWRDFARSVGVTTHMLSSAEA 216596002999 1 probable transmembrane helix predicted at aa 20-37 216596003000 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 216596003001 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216596003002 putative DNA binding site [nucleotide binding]; other site 216596003003 putative Zn2+ binding site [ion binding]; other site 216596003004 AsnC family; Region: AsnC_trans_reg; pfam01037 216596003005 Pfam match to entry PF01037.8 AsnC_trans_reg, score 121.6, E-value 1.9e-33 216596003006 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 216596003007 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596003008 Walker A/P-loop; other site 216596003009 ATP binding site [chemical binding]; other site 216596003010 Q-loop/lid; other site 216596003011 ABC transporter signature motif; other site 216596003012 Walker B; other site 216596003013 D-loop; other site 216596003014 H-loop/switch region; other site 216596003015 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216596003016 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596003017 Walker A/P-loop; other site 216596003018 ATP binding site [chemical binding]; other site 216596003019 Q-loop/lid; other site 216596003020 ABC transporter signature motif; other site 216596003021 Walker B; other site 216596003022 D-loop; other site 216596003023 H-loop/switch region; other site 216596003024 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216596003025 Pfam match to entry PF00005.11 ABC_tran, score 213.6, E-value 3.7e-61 216596003026 Pfam match to entry PF00005.11 ABC_tran, score 184.9, E-value 1.6e-52 216596003027 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 216596003028 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596003029 dimer interface [polypeptide binding]; other site 216596003030 ABC-ATPase subunit interface; other site 216596003031 Pfam match to entry PF00528.10 BPD_transp_1, score 144.8, E-value 1.9e-40 216596003032 5 probable transmembrane helices predicted at aa 24-46, 90-112, 139-161,215-237 and 252-274 216596003033 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 216596003034 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596003035 dimer interface [polypeptide binding]; other site 216596003036 conserved gate region; other site 216596003037 putative PBP binding loops; other site 216596003038 ABC-ATPase subunit interface; other site 216596003039 Pfam match to entry PF00528.10 BPD_transp_1, score 141.5, E-value 1.9e-39 216596003040 6 probable transmembrane helices predicted at aa 38-60, 135-157, 169-191,211-228, 273-295 and 319-341 216596003041 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 216596003042 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 216596003043 Pfam match to entry PF00496.9 SBP_bac_5, score 65.0, E-value 2e-16 216596003044 1 probable transmembrane helix predicted at aa 29-51 216596003045 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 216596003046 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 216596003047 Pfam match to entry PF00702.10 Hydrolase, score 14.9, E-value 0.01 216596003048 hypothetical protein; Provisional; Region: PRK05965 216596003049 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 216596003050 inhibitor-cofactor binding pocket; inhibition site 216596003051 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596003052 catalytic residue [active] 216596003053 Pfam match to entry PF00202.8 Aminotran_3, score 352.5, E-value 5.8e-103 216596003054 putative acetyltransferase; Provisional; Region: PRK03624 216596003055 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216596003056 Coenzyme A binding pocket [chemical binding]; other site 216596003057 Pfam match to entry PF00583.9 Acetyltransf_1, score 65.0, E-value 2e-16 216596003058 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 216596003059 Pfam match to entry PF07005.1 DUF1537, score 331.9, E-value 9.2e-97 216596003060 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 216596003061 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 216596003062 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 216596003063 Pfam match to entry PF03446.3 NAD_binding_2, score -72.6, E-value 0.00021 216596003064 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 216596003065 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596003066 putative substrate translocation pore; other site 216596003067 Pfam match to entry PF00083.10 Sugar_tr, score -80.1, E-value 0.00015 216596003068 12 probable transmembrane helices predicted at aa 71-88, 103-125, 138-160,165-187, 199-221, 234-256, 301-323, 333-355, 367-386,390-412, 425-447 and 457-476 216596003069 Pfam match to entry PF07690.1 MFS_1, score 210.5,E-value 3.2e-60 216596003070 Transcriptional regulators [Transcription]; Region: PurR; COG1609 216596003071 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216596003072 DNA binding site [nucleotide binding] 216596003073 domain linker motif; other site 216596003074 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 216596003075 putative dimerization interface [polypeptide binding]; other site 216596003076 putative ligand binding site [chemical binding]; other site 216596003077 Pfam match to entry PF00356.8 LacI, score 39.6,E-value 9.1e-09 216596003078 Predicted helix-turn-helix motif with score 2341.000, SD 7.16 at aa 78-99, sequence VTLAEVAEAAGVGESTVSRVLR 216596003079 Pfam match to entry PF00532.8 Peripla_BP_1, score 15.8, E-value 3e-05 216596003080 putative aldolase; Validated; Region: PRK08130 216596003081 intersubunit interface [polypeptide binding]; other site 216596003082 active site 216596003083 Zn2+ binding site [ion binding]; other site 216596003084 Pfam match to entry PF00596.9 Aldolase_II, score 176.7, E-value 4.9e-50 216596003085 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 216596003086 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 216596003087 Pfam match to entry PF00702.10 Hydrolase, score 26.4, E-value 8.4e-05 216596003088 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 216596003089 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 216596003090 Pfam match to entry PF01266.8 DAO, score -46.3,E-value 5.5e-05 216596003091 Protein of unknown function (DUF982); Region: DUF982; pfam06169 216596003092 Pfam match to entry PF06169.1 DUF982, score 26.2,E-value 5e-06 216596003093 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 216596003094 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 216596003095 ATP binding site [chemical binding]; other site 216596003096 Pfam match to entry PF00899.8 ThiF, score 28.3,E-value 1.2e-06 216596003097 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 216596003098 Pfam match to entry PF00082.10 Peptidase_S8, score -50.6, E-value 5.5e-05 216596003099 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 216596003100 active site 216596003101 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 216596003102 TPR repeat; Region: TPR_11; pfam13414 216596003103 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216596003104 TPR motif; other site 216596003105 binding surface 216596003106 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216596003107 TPR motif; other site 216596003108 binding surface 216596003109 succinic semialdehyde dehydrogenase; Region: PLN02278 216596003110 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 216596003111 tetramerization interface [polypeptide binding]; other site 216596003112 NAD(P) binding site [chemical binding]; other site 216596003113 catalytic residues [active] 216596003114 Pfam match to entry PF00171.9 Aldedh, score 647.1, E-value 1.2e-191 216596003115 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 216596003116 tartrate dehydrogenase; Region: TTC; TIGR02089 216596003117 Pfam match to entry PF00180.7 Iso_dh, score 332.3, E-value 6.8e-97 216596003118 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 216596003119 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 216596003120 NAD(P) binding site [chemical binding]; other site 216596003121 catalytic residues [active] 216596003122 Pfam match to entry PF00171.9 Aldedh, score 552.6, E-value 3.4e-163 216596003123 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 216596003124 Pfam match to entry PF05899.1 DUF861, score 130.4, E-value 4.3e-36 216596003125 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 216596003126 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 216596003127 putative ligand binding site [chemical binding]; other site 216596003128 NAD binding site [chemical binding]; other site 216596003129 dimerization interface [polypeptide binding]; other site 216596003130 catalytic site [active] 216596003131 Pfam match to entry PF02826.5 2-Hacid_dh_C, score 105.8, E-value 1.1e-28 216596003132 acetylornithine deacetylase; Provisional; Region: PRK07522 216596003133 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 216596003134 metal binding site [ion binding]; metal-binding site 216596003135 putative dimer interface [polypeptide binding]; other site 216596003136 Pfam match to entry PF07687.1 M20_dimer, score 77.9, E-value 2.6e-20 216596003137 Pfam match to entry PF01546.13 Peptidase_M20, score 87.2, E-value 4.2e-23 216596003138 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 216596003139 Pfam match to entry PF00583.9 Acetyltransf_1, score 25.0, E-value 0.00022 216596003140 4 probable transmembrane helices predicted at aa 13-35, 55-72, 77-94 and 99-116 216596003141 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596003142 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596003143 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216596003144 dimerization interface [polypeptide binding]; other site 216596003145 Pfam match to entry PF00126.10 HTH_1, score 24.9,E-value 9.6e-06 216596003146 Pfam match to entry PF03466.5 LysR_substrate, score 102.1, E-value 1.4e-27 216596003147 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 216596003148 HPP family; Region: HPP; pfam04982 216596003149 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 216596003150 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 216596003151 4 probable transmembrane helices predicted at aa 79-101, 106-128, 141-163 and 198-220 216596003152 Pfam match to entry PF04982.3 HPP, score 210.5,E-value 3.2e-60 216596003153 Pfam match to entry PF00571.14 CBS, score 35.5,E-value 1.5e-07 216596003154 Pfam match to entry PF00571.14 CBS, score 34.5,E-value 3.1e-07 216596003155 Predicted helix-turn-helix motif with score 1323.000, SD 3.69 at aa 13-34, sequence LESSELAERFGLSLADLRRHMR 216596003156 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 216596003157 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 216596003158 ring oligomerisation interface [polypeptide binding]; other site 216596003159 ATP/Mg binding site [chemical binding]; other site 216596003160 stacking interactions; other site 216596003161 hinge regions; other site 216596003162 Pfam match to entry PF00118.12 Cpn60_TCP1, score 675.4, E-value 3.6e-200 216596003163 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 216596003164 oligomerisation interface [polypeptide binding]; other site 216596003165 mobile loop; other site 216596003166 roof hairpin; other site 216596003167 Pfam match to entry PF00166.8 Cpn10, score 222.9,E-value 5.8e-64 216596003168 Transposase; Region: HTH_Tnp_1; pfam01527 216596003169 Pfam match to entry PF01527.7 Transposase_8, score 58.6, E-value 1.7e-14 216596003170 Predicted helix-turn-helix motif with score 1503.000, SD 4.31 at aa 50-71, sequence AVISEIARAAGIHVSQLFRWRK 216596003171 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 216596003172 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 216596003173 Pfam match to entry PF05717.2 Transposase_34, score 197.6, E-value 2.4e-56 216596003174 similarity:fasta; SWALL:Y4HP_RHISN (SWALL:P50360); Rhizobium sp.; hypothetical 61.7 kDa protein y4hp; length 552 aa; id=62.39; ungapped id=63.32; E()=1.9e-109; 476 aa overlap; query 7-479 aa; subject 7-478 aa; putative transposase-related protein,pseudogene 216596003175 Pfam match to entry PF03050.4 Transposase_25, score 417.2, E-value 2e-122 216596003176 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 216596003177 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 216596003178 catalytic residues [active] 216596003179 catalytic nucleophile [active] 216596003180 Recombinase; Region: Recombinase; pfam07508 216596003181 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 216596003182 Predicted helix-turn-helix motif with score 1745.000, SD 5.13 at aa 616-637, sequence LTMTEAAAALGVTNHRIRHLIK 216596003183 Pfam match to entry PF07508.1 Recombinase, score 31.1, E-value 3.3e-06 216596003184 Pfam match to entry PF00239.10 Resolvase, score -13.4, E-value 0.0011 216596003185 GAD-like domain; Region: GAD-like; pfam08887 216596003186 Domain of unknown function (DUF1851); Region: DUF1851; pfam08906 216596003187 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 216596003188 HD domain; Region: HD_4; pfam13328 216596003189 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 216596003190 nucleotide binding site/active site [active] 216596003191 HIT family signature motif; other site 216596003192 catalytic residue [active] 216596003193 Pfam match to entry PF01230.10 HIT, score 20.1,E-value 1.7e-06 216596003194 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; cl01752 216596003195 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 216596003196 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 216596003197 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 216596003198 Pfam match to entry PF01547.11 SBP_bac_1, score 89.5, E-value 8.6e-24 216596003199 1 probable transmembrane helix predicted at aa 20-42 216596003200 5 probable transmembrane helices predicted at aa 42-64, 96-118, 128-150,162-184 and 194-216 216596003201 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 216596003202 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 216596003203 Walker A/P-loop; other site 216596003204 ATP binding site [chemical binding]; other site 216596003205 Q-loop/lid; other site 216596003206 ABC transporter signature motif; other site 216596003207 Walker B; other site 216596003208 D-loop; other site 216596003209 H-loop/switch region; other site 216596003210 TOBE domain; Region: TOBE; pfam03459 216596003211 Pfam match to entry PF03459.4 TOBE, score 34.3,E-value 3.5e-07 216596003212 Pfam match to entry PF00005.11 ABC_tran, score 215.8, E-value 8.2e-62 216596003213 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 216596003214 Pfam match to entry PF07470.1 Glyco_hydro_88, score 197.7, E-value 2.3e-56 216596003215 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216596003216 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596003217 dimer interface [polypeptide binding]; other site 216596003218 conserved gate region; other site 216596003219 putative PBP binding loops; other site 216596003220 ABC-ATPase subunit interface; other site 216596003221 Pfam match to entry PF00528.10 BPD_transp_1, score 62.1, E-value 1.5e-15 216596003222 6 probable transmembrane helices predicted at aa 13-35, 68-90, 110-132,142-164, 184-206 and 241-263 216596003223 Predicted helix-turn-helix motif with score 1014.000, SD 2.64 at aa 168-189, sequence TELCEAARIDGMNEYQIWARIM 216596003224 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 216596003225 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596003226 dimer interface [polypeptide binding]; other site 216596003227 conserved gate region; other site 216596003228 putative PBP binding loops; other site 216596003229 ABC-ATPase subunit interface; other site 216596003230 Pfam match to entry PF00528.10 BPD_transp_1, score 51.1, E-value 3.1e-12 216596003231 6 probable transmembrane helices predicted at aa 36-58, 98-120, 133-152,182-204, 229-251 and 283-305 216596003232 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 216596003233 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 216596003234 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 216596003235 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596003236 active site 216596003237 phosphorylation site [posttranslational modification] 216596003238 intermolecular recognition site; other site 216596003239 dimerization interface [polypeptide binding]; other site 216596003240 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216596003241 DNA binding site [nucleotide binding] 216596003242 Pfam match to entry PF00072.10 Response_reg, score 34.3, E-value 3.5e-07 216596003243 Pfam match to entry PF00486.12 Trans_reg_C, score 69.4, E-value 9.9e-18 216596003244 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 216596003245 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 216596003246 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216596003247 dimer interface [polypeptide binding]; other site 216596003248 phosphorylation site [posttranslational modification] 216596003249 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596003250 ATP binding site [chemical binding]; other site 216596003251 Mg2+ binding site [ion binding]; other site 216596003252 G-X-G motif; other site 216596003253 1 probable transmembrane helix predicted at aa 36-58 216596003254 Pfam match to entry PF00672.10 HAMP, score 26.3,E-value 9e-05 216596003255 Pfam match to entry PF00512.10 HisKA, score 58.1,E-value 2.5e-14 216596003256 Pfam match to entry PF02518.9 HATPase_c, score 129.8, E-value 6.5e-36 216596003257 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 216596003258 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596003259 dimer interface [polypeptide binding]; other site 216596003260 conserved gate region; other site 216596003261 putative PBP binding loops; other site 216596003262 ABC-ATPase subunit interface; other site 216596003263 Pfam match to entry PF00528.10 BPD_transp_1, score 113.6, E-value 4.9e-31 216596003264 6 probable transmembrane helices predicted at aa 65-84, 129-148, 161-183,188-207, 240-262 and 282-304 216596003265 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 216596003266 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 216596003267 Walker A/P-loop; other site 216596003268 ATP binding site [chemical binding]; other site 216596003269 Q-loop/lid; other site 216596003270 ABC transporter signature motif; other site 216596003271 Walker B; other site 216596003272 D-loop; other site 216596003273 H-loop/switch region; other site 216596003274 Pfam match to entry PF00005.11 ABC_tran, score 202.0, E-value 1.1e-57 216596003275 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 216596003276 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 216596003277 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 216596003278 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 216596003279 conserved cys residue [active] 216596003280 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216596003281 Helix-turn-helix domain; Region: HTH_18; pfam12833 216596003282 Pfam match to entry PF00165.8 HTH_AraC, score 13.2, E-value 0.1 216596003283 Pfam match to entry PF00165.8 HTH_AraC, score 33.3, E-value 7e-07 216596003284 Predicted helix-turn-helix motif with score 1470.000, SD 4.19 at aa 247-268, sequence WSVASLARLSGASPRNLSRLFN 216596003285 Pfam match to entry PF01965.10 DJ-1_PfpI, score 43.0, E-value 8.6e-10 216596003286 Isochorismatase family; Region: Isochorismatase; pfam00857 216596003287 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 216596003288 catalytic triad [active] 216596003289 conserved cis-peptide bond; other site 216596003290 Pfam match to entry PF00857.9 Isochorismatase, score 21.6, E-value 3.2e-09 216596003291 Transcriptional regulators [Transcription]; Region: FadR; COG2186 216596003292 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596003293 DNA-binding site [nucleotide binding]; DNA binding site 216596003294 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 216596003295 Pfam match to entry PF00392.9 GntR, score 87.4,E-value 3.6e-23 216596003296 Predicted transcriptional regulator [Transcription]; Region: COG3905 216596003297 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 216596003298 Pfam match to entry PF05016.3 Plasmid_stabil, score 69.1, E-value 1.2e-17 216596003299 Transcriptional regulators [Transcription]; Region: PurR; COG1609 216596003300 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216596003301 DNA binding site [nucleotide binding] 216596003302 domain linker motif; other site 216596003303 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 216596003304 dimerization interface [polypeptide binding]; other site 216596003305 ligand binding site [chemical binding]; other site 216596003306 Pfam match to entry PF00532.8 Peripla_BP_1, score 43.5, E-value 6e-10 216596003307 Pfam match to entry PF00356.8 LacI, score 44.8,E-value 2.5e-10 216596003308 Predicted helix-turn-helix motif with score 2015.000, SD 6.05 at aa 2-23, sequence TTIRDVARLAGVSISTVSLALN 216596003309 Alpha-L-fucosidase; Region: Alpha_L_fucos; pfam01120 216596003310 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 216596003311 Pfam match to entry PF01120.7 Alpha_L_fucos, score -25.9, E-value 2.5e-14 216596003312 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 216596003313 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 216596003314 Pfam match to entry PF01547.11 SBP_bac_1, score 80.6, E-value 4.2e-21 216596003315 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 216596003316 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596003317 dimer interface [polypeptide binding]; other site 216596003318 conserved gate region; other site 216596003319 putative PBP binding loops; other site 216596003320 ABC-ATPase subunit interface; other site 216596003321 6 probable transmembrane helices predicted at aa 43-65, 104-126, 138-160,184-206, 237-259 and 289-311 216596003322 Pfam match to entry PF00528.10 BPD_transp_1, score 68.8, E-value 1.4e-17 216596003323 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216596003324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596003325 dimer interface [polypeptide binding]; other site 216596003326 conserved gate region; other site 216596003327 putative PBP binding loops; other site 216596003328 ABC-ATPase subunit interface; other site 216596003329 7 probable transmembrane helices predicted at aa 27-49, 89-111, 124-146,156-178, 199-221, 226-248 and 255-277 216596003330 Pfam match to entry PF00528.10 BPD_transp_1, score 34.9, E-value 2.3e-07 216596003331 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 216596003332 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 216596003333 putative ligand binding site [chemical binding]; other site 216596003334 Pfam match to entry PF00532.8 Peripla_BP_1, score -27.4, E-value 0.0075 216596003335 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216596003336 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 216596003337 dimer interface [polypeptide binding]; other site 216596003338 putative CheW interface [polypeptide binding]; other site 216596003339 2 probable transmembrane helices predicted at aa 15-37 and 300-322 216596003340 Pfam match to entry PF00672.10 HAMP, score 44.3,E-value 3.4e-10 216596003341 Pfam match to entry PF00015.9 MCPsignal, score 275.2, E-value 1e-79 216596003342 Protein of unknown function (DUF3422); Region: DUF3422; pfam11902 216596003343 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 216596003344 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 216596003345 Pfam match to entry PF01547.11 SBP_bac_1, score 60.9, E-value 3.4e-15 216596003346 1 probable transmembrane helix predicted at aa 7-26 216596003347 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 216596003348 Pfam match to entry PF07470.1 Glyco_hydro_88, score 452.5, E-value 4.4e-133 216596003349 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 216596003350 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 216596003351 Pfam match to entry PF00295.7 Glyco_hydro_28, score 30.8, E-value 6.2e-09 216596003352 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 216596003353 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 216596003354 Walker A/P-loop; other site 216596003355 ATP binding site [chemical binding]; other site 216596003356 Q-loop/lid; other site 216596003357 ABC transporter signature motif; other site 216596003358 Walker B; other site 216596003359 D-loop; other site 216596003360 H-loop/switch region; other site 216596003361 TOBE domain; Region: TOBE; pfam03459 216596003362 Pfam match to entry PF00005.11 ABC_tran, score 230.6, E-value 2.8e-66 216596003363 Pfam match to entry PF03459.4 TOBE, score 41.0,E-value 3.3e-09 216596003364 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 216596003365 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596003366 ABC-ATPase subunit interface; other site 216596003367 putative PBP binding loops; other site 216596003368 6 probable transmembrane helices predicted at aa 39-61, 112-134, 147-166,195-217, 238-260 and 298-320 216596003369 Pfam match to entry PF00528.10 BPD_transp_1, score 52.1, E-value 1.5e-12 216596003370 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216596003371 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596003372 dimer interface [polypeptide binding]; other site 216596003373 conserved gate region; other site 216596003374 putative PBP binding loops; other site 216596003375 ABC-ATPase subunit interface; other site 216596003376 6 probable transmembrane helices predicted at aa 21-43, 149-168, 181-203,213-235, 256-278 and 312-334 216596003377 Pfam match to entry PF00528.10 BPD_transp_1, score 65.0, E-value 2e-16 216596003378 Transcriptional regulators [Transcription]; Region: MarR; COG1846 216596003379 MarR family; Region: MarR_2; cl17246 216596003380 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 216596003381 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 216596003382 nucleotide binding site [chemical binding]; other site 216596003383 Pfam match to entry PF00480.8 ROK, score 12.5,E-value 1.1e-07 216596003384 Predicted helix-turn-helix motif with score 1104.000, SD 2.95 at aa 40-61, sequence IERSDLTEPLDLTQQSLHRIVA 216596003385 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216596003386 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216596003387 Pfam match to entry PF00165.8 HTH_AraC, score 26.1, E-value 0.00011 216596003388 Pfam match to entry PF00165.8 HTH_AraC, score 29.0, E-value 1.4e-05 216596003389 Transcriptional regulators [Transcription]; Region: PurR; COG1609 216596003390 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216596003391 DNA binding site [nucleotide binding] 216596003392 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 216596003393 ligand binding site [chemical binding]; other site 216596003394 dimerization interface [polypeptide binding]; other site 216596003395 Pfam match to entry PF00532.8 Peripla_BP_1, score 34.4, E-value 3.2e-07 216596003396 Pfam match to entry PF00356.8 LacI, score 30.2,E-value 6.2e-06 216596003397 Predicted helix-turn-helix motif with score 1533.000, SD 4.41 at aa 29-50, sequence VNLKDVARDADVSLSTASHALN 216596003398 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216596003399 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216596003400 Pfam match to entry PF00440.8 TetR_N, score 76.0,E-value 1e-19 216596003401 Predicted helix-turn-helix motif with score 1971.000, SD 5.90 at aa 36-57, sequence TRVEDIADRVGVTKGTVYVYFE 216596003402 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 216596003403 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 216596003404 HlyD family secretion protein; Region: HlyD_3; pfam13437 216596003405 Pfam match to entry PF00529.8 HlyD, score 27.5,E-value 4e-05 216596003406 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 216596003407 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 216596003408 HlyD family secretion protein; Region: HlyD_3; pfam13437 216596003409 Pfam match to entry PF00529.8 HlyD, score 16.9,E-value 0.00023 216596003410 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 216596003411 Pfam match to entry PF00873.7 ACR_tran, score 313.7, E-value 2.7e-91 216596003412 11 probable transmembrane helices predicted at aa 15-33, 336-358, 362-384,391-413, 433-452, 465-487, 520-542, 856-878, 882-901,908-930 and 985-1007 216596003413 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782 216596003414 Pfam match to entry PF05990.1 DUF900, score 256.9, E-value 3.5e-74 216596003415 Domain of unknown function (DUF4272); Region: DUF4272; pfam14094 216596003416 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 216596003417 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 216596003418 oligomer interface [polypeptide binding]; other site 216596003419 metal binding site [ion binding]; metal-binding site 216596003420 metal binding site [ion binding]; metal-binding site 216596003421 putative Cl binding site [ion binding]; other site 216596003422 basic sphincter; other site 216596003423 hydrophobic gate; other site 216596003424 periplasmic entrance; other site 216596003425 Pfam match to entry PF01544.8 CorA, score 163.6,E-value 4.1e-46 216596003426 2 probable transmembrane helices predicted at aa 290-309 and 319-341 216596003427 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 216596003428 3 probable transmembrane helices predicted at aa 30-52, 65-96 and 111-130 216596003429 Similar to N-terminus to codon 120 of Streptomyces coelicolor hypothetical protein sco6217 SWALL:Q9RKV9 (EMBL:AL939126) (216 aa); similarity:fasta; SWALL:Q9RKV9 (EMBL:AL939126); Streptomyces coelicolor; hypothetical protein sco6217; length 216 aa; id=31.57; ungapped id=39.13; E()=9.4; 114 aa overlap; query 1-96 aa; subject 1-110 aa; conserved hypothetical protein, pseudogene 216596003430 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 216596003431 Pfam match to entry PF01689.6 Hyratase_decarb, score 26.4, E-value 5.9e-07 216596003432 Phosphotransferase enzyme family; Region: APH; pfam01636 216596003433 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 216596003434 active site 216596003435 substrate binding site [chemical binding]; other site 216596003436 ATP binding site [chemical binding]; other site 216596003437 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 216596003438 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 216596003439 Pfam match to entry PF00753.13 Lactamase_B, score 83.6, E-value 5.1e-22 216596003440 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 216596003441 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 216596003442 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 216596003443 active site 216596003444 homodimer interface [polypeptide binding]; other site 216596003445 catalytic site [active] 216596003446 acceptor binding site [chemical binding]; other site 216596003447 Pfam match to entry PF00128.11 Alpha-amylase, score -23.0, E-value 1.9e-08 216596003448 trehalose synthase; Region: treS_nterm; TIGR02456 216596003449 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 216596003450 active site 216596003451 catalytic site [active] 216596003452 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 216596003453 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 216596003454 Pfam match to entry PF00128.11 Alpha-amylase, score 251.4, E-value 1.6e-72 216596003455 glycogen branching enzyme; Provisional; Region: PRK05402 216596003456 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 216596003457 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 216596003458 active site 216596003459 catalytic site [active] 216596003460 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 216596003461 Pfam match to entry PF02922.6 Isoamylase_N, score 2.3, E-value 0.019 216596003462 Pfam match to entry PF02922.6 Isoamylase_N, score 94.1, E-value 3.4e-25 216596003463 Pfam match to entry PF00128.11 Alpha-amylase, score -31.8, E-value 6.4e-08 216596003464 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 216596003465 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 216596003466 Walker A/P-loop; other site 216596003467 ATP binding site [chemical binding]; other site 216596003468 Q-loop/lid; other site 216596003469 ABC transporter signature motif; other site 216596003470 Walker B; other site 216596003471 D-loop; other site 216596003472 H-loop/switch region; other site 216596003473 Pfam match to entry PF00005.11 ABC_tran, score 182.6, E-value 7.9e-52 216596003474 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 216596003475 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 216596003476 ABC-ATPase subunit interface; other site 216596003477 dimer interface [polypeptide binding]; other site 216596003478 putative PBP binding regions; other site 216596003479 9 probable transmembrane helices predicted at aa 13-35, 76-98, 105-127,132-154, 161-183, 203-225, 252-274, 289-308 and 320-342 216596003480 Pfam match to entry PF01032.7 FecCD, score 310.4,E-value 2.7e-90 216596003481 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 216596003482 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 216596003483 intersubunit interface [polypeptide binding]; other site 216596003484 Pfam match to entry PF01497.7 Peripla_BP_2, score 37.2, E-value 4.7e-08 216596003485 RES domain; Region: RES; pfam08808 216596003486 Helix-turn-helix domain; Region: HTH_17; cl17695 216596003487 Predicted helix-turn-helix motif with score 1251.000, SD 3.45 at aa 97-118, sequence MSAEDAGRILGISRQAVDKRRR 216596003488 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 216596003489 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 216596003490 dimerization interface [polypeptide binding]; other site 216596003491 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 216596003492 dimerization interface [polypeptide binding]; other site 216596003493 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 216596003494 dimerization interface [polypeptide binding]; other site 216596003495 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 216596003496 dimerization interface [polypeptide binding]; other site 216596003497 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 216596003498 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 216596003499 dimerization interface [polypeptide binding]; other site 216596003500 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 216596003501 dimerization interface [polypeptide binding]; other site 216596003502 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 216596003503 dimerization interface [polypeptide binding]; other site 216596003504 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 216596003505 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 216596003506 dimerization interface [polypeptide binding]; other site 216596003507 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 216596003508 dimerization interface [polypeptide binding]; other site 216596003509 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 216596003510 dimerization interface [polypeptide binding]; other site 216596003511 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 216596003512 dimerization interface [polypeptide binding]; other site 216596003513 GAF domain; Region: GAF_2; pfam13185 216596003514 GAF domain; Region: GAF; pfam01590 216596003515 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 216596003516 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216596003517 dimer interface [polypeptide binding]; other site 216596003518 phosphorylation site [posttranslational modification] 216596003519 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596003520 ATP binding site [chemical binding]; other site 216596003521 Mg2+ binding site [ion binding]; other site 216596003522 G-X-G motif; other site 216596003523 Response regulator receiver domain; Region: Response_reg; pfam00072 216596003524 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596003525 active site 216596003526 phosphorylation site [posttranslational modification] 216596003527 intermolecular recognition site; other site 216596003528 dimerization interface [polypeptide binding]; other site 216596003529 Response regulator receiver domain; Region: Response_reg; pfam00072 216596003530 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596003531 active site 216596003532 phosphorylation site [posttranslational modification] 216596003533 intermolecular recognition site; other site 216596003534 dimerization interface [polypeptide binding]; other site 216596003535 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 216596003536 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596003537 active site 216596003538 phosphorylation site [posttranslational modification] 216596003539 intermolecular recognition site; other site 216596003540 dimerization interface [polypeptide binding]; other site 216596003541 Pfam match to entry PF00672.10 HAMP, score 40.9,E-value 3.6e-09 216596003542 Pfam match to entry PF00672.10 HAMP, score 43.3,E-value 6.8e-10 216596003543 Pfam match to entry PF00672.10 HAMP, score 44.4,E-value 3.2e-10 216596003544 Pfam match to entry PF00672.10 HAMP, score 41.0,E-value 3.4e-09 216596003545 Pfam match to entry PF00672.10 HAMP, score 42.3,E-value 1.4e-09 216596003546 Pfam match to entry PF00672.10 HAMP, score 45.0,E-value 2.1e-10 216596003547 Pfam match to entry PF00672.10 HAMP, score 45.1,E-value 2e-10 216596003548 Pfam match to entry PF00672.10 HAMP, score 47.2,E-value 4.5e-11 216596003549 Pfam match to entry PF00672.10 HAMP, score 49.1,E-value 1.3e-11 216596003550 Pfam match to entry PF00672.10 HAMP, score 38.4,E-value 2e-08 216596003551 Pfam match to entry PF00672.10 HAMP, score 46.6,E-value 6.8e-11 216596003552 Pfam match to entry PF01590.11 GAF, score 47.0,E-value 5.3e-11 216596003553 Pfam match to entry PF00512.10 HisKA, score 80.4,E-value 4.7e-21 216596003554 Pfam match to entry PF02518.9 HATPase_c, score 153.2, E-value 5.9e-43 216596003555 Pfam match to entry PF00072.10 Response_reg, score 49.7, E-value 7.9e-12 216596003556 Pfam match to entry PF00072.10 Response_reg, score 55.2, E-value 1.7e-13 216596003557 Pfam match to entry PF00072.10 Response_reg, score 113.6, E-value 4.6e-31 216596003558 Response regulator receiver domain; Region: Response_reg; pfam00072 216596003559 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596003560 active site 216596003561 phosphorylation site [posttranslational modification] 216596003562 intermolecular recognition site; other site 216596003563 dimerization interface [polypeptide binding]; other site 216596003564 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 216596003565 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216596003566 dimer interface [polypeptide binding]; other site 216596003567 phosphorylation site [posttranslational modification] 216596003568 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596003569 ATP binding site [chemical binding]; other site 216596003570 Mg2+ binding site [ion binding]; other site 216596003571 G-X-G motif; other site 216596003572 Response regulator receiver domain; Region: Response_reg; pfam00072 216596003573 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596003574 active site 216596003575 phosphorylation site [posttranslational modification] 216596003576 intermolecular recognition site; other site 216596003577 dimerization interface [polypeptide binding]; other site 216596003578 Pfam match to entry PF00072.10 Response_reg, score 77.4, E-value 3.7e-20 216596003579 Pfam match to entry PF00512.10 HisKA, score 36.0,E-value 1e-07 216596003580 Pfam match to entry PF02518.9 HATPase_c, score 112.6, E-value 9.7e-31 216596003581 Pfam match to entry PF00072.10 Response_reg, score 68.7, E-value 1.5e-17 216596003582 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 216596003583 Pfam match to entry PF05016.3 Plasmid_stabil, score 41.2, E-value 3e-09 216596003584 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 216596003585 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 216596003586 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 216596003587 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 216596003588 catalytic site [active] 216596003589 active site 216596003590 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 216596003591 Pfam match to entry PF02922.6 Isoamylase_N, score 5.0, E-value 0.01 216596003592 Pfam match to entry PF00128.11 Alpha-amylase, score 27.4, E-value 2e-11 216596003593 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 216596003594 Pfam match to entry PF02446.5 4a_glucanotrans, score 321.8, E-value 1e-93 216596003595 1 probable transmembrane helix predicted at aa 60-82 216596003596 2 probable transmembrane helices predicted at aa 65-84 and 111-133 216596003597 1 probable transmembrane helix predicted at aa 28-50 216596003598 1 probable transmembrane helix predicted at aa 85-107 216596003599 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 216596003600 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216596003601 DNA binding residues [nucleotide binding] 216596003602 dimerization interface [polypeptide binding]; other site 216596003603 Pfam match to entry PF00196.8 GerE, score 49.9,E-value 6.9e-12 216596003604 Predicted helix-turn-helix motif with score 1511.000, SD 4.33 at aa 326-347, sequence HSPKEVAIADHISYETVRTHLR 216596003605 Transcriptional regulators [Transcription]; Region: PurR; COG1609 216596003606 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216596003607 DNA binding site [nucleotide binding] 216596003608 domain linker motif; other site 216596003609 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 216596003610 dimerization interface [polypeptide binding]; other site 216596003611 ligand binding site [chemical binding]; other site 216596003612 Pfam match to entry PF00532.8 Peripla_BP_1, score 77.4, E-value 3.8e-20 216596003613 Predicted helix-turn-helix motif with score 1222.000, SD 3.35 at aa 11-32, sequence VTVADVAKAAKVSKATAARVLG 216596003614 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 216596003615 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 216596003616 substrate binding pocket [chemical binding]; other site 216596003617 membrane-bound complex binding site; other site 216596003618 hinge residues; other site 216596003619 Pfam match to entry PF00497.8 SBP_bac_3, score 191.0, E-value 2.3e-54 216596003620 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 216596003621 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596003622 dimer interface [polypeptide binding]; other site 216596003623 conserved gate region; other site 216596003624 putative PBP binding loops; other site 216596003625 ABC-ATPase subunit interface; other site 216596003626 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 216596003627 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 216596003628 Walker A/P-loop; other site 216596003629 ATP binding site [chemical binding]; other site 216596003630 Q-loop/lid; other site 216596003631 ABC transporter signature motif; other site 216596003632 Walker B; other site 216596003633 D-loop; other site 216596003634 H-loop/switch region; other site 216596003635 Pfam match to entry PF00528.10 BPD_transp_1, score 92.5, E-value 1e-24 216596003636 3 probable transmembrane helices predicted at aa 34-56, 71-88 and 95-117 216596003637 Pfam match to entry PF00005.11 ABC_tran, score 241.1, E-value 2e-69 216596003638 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 216596003639 Pfam match to entry PF01266.8 DAO, score -80.7,E-value 0.0029 216596003640 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 216596003641 putative catalytic site [active] 216596003642 putative metal binding site [ion binding]; other site 216596003643 putative phosphate binding site [ion binding]; other site 216596003644 Pfam match to entry PF03372.7 Exo_endo_phos, score 74.6, E-value 2.7e-19 216596003645 Predicted integral membrane protein [Function unknown]; Region: COG0392 216596003646 7 probable transmembrane helices predicted at aa 5-27, 39-61, 81-103, 123-145,160-182, 195-217 and 274-296 216596003647 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 216596003648 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 216596003649 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 216596003650 putative active site [active] 216596003651 putative active site [active] 216596003652 catalytic site [active] 216596003653 catalytic site [active] 216596003654 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 216596003655 putative active site [active] 216596003656 catalytic site [active] 216596003657 Pfam match to entry PF00614.9 PLDc, score 29.0,E-value 1.4e-05 216596003658 Pfam match to entry PF00614.9 PLDc, score 33.4,E-value 6.7e-07 216596003659 Uncharacterized conserved protein [Function unknown]; Region: COG1415 216596003660 Pfam match to entry PF05559.1 DUF763, score 698.4, E-value 4.3e-207 216596003661 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 216596003662 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 216596003663 EamA-like transporter family; Region: EamA; pfam00892 216596003664 10 probable transmembrane helices predicted at aa 16-38, 48-70, 91-113, 117-136,141-158, 162-184, 197-216, 221-243, 248-270 and 280-297 216596003665 Pfam match to entry PF00892.8 DUF6, score 44.3,E-value 3.5e-10 216596003666 Pfam match to entry PF00892.8 DUF6, score 48.6,E-value 1.8e-11 216596003667 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 216596003668 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596003669 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 216596003670 putative dimerization interface [polypeptide binding]; other site 216596003671 Pfam match to entry PF03466.5 LysR_substrate, score 166.9, E-value 4.2e-47 216596003672 Pfam match to entry PF00126.10 HTH_1, score 67.0,E-value 5.2e-17 216596003673 Predicted helix-turn-helix motif with score 1680.000, SD 4.91 at aa 16-37, sequence EHLTKAAFAIGLTPSAVSSAIR 216596003674 Predicted membrane protein [Function unknown]; Region: COG2855 216596003675 11 probable transmembrane helices predicted at aa 21-43, 58-80, 93-112, 116-138,145-167, 177-199, 206-228, 238-257, 264-283, 293-315 and 328-350 216596003676 Pfam match to entry PF03601.3 Cons_hypoth698, score 227.0, E-value 3.4e-65 216596003677 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 216596003678 Coenzyme A transferase; Region: CoA_trans; smart00882 216596003679 Coenzyme A transferase; Region: CoA_trans; cl17247 216596003680 Pfam match to entry PF01144.9 CoA_trans, score 115.3, E-value 1.5e-31 216596003681 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 216596003682 classical (c) SDRs; Region: SDR_c; cd05233 216596003683 NAD(P) binding site [chemical binding]; other site 216596003684 active site 216596003685 Pfam match to entry PF00106.11 adh_short, score 243.1, E-value 4.9e-70 216596003686 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 216596003687 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 216596003688 dimer interaction site [polypeptide binding]; other site 216596003689 substrate-binding tunnel; other site 216596003690 active site 216596003691 catalytic site [active] 216596003692 substrate binding site [chemical binding]; other site 216596003693 Pfam match to entry PF01575.6 MaoC_dehydratas, score 90.4, E-value 4.5e-24 216596003694 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 216596003695 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596003696 DNA-binding site [nucleotide binding]; DNA binding site 216596003697 UTRA domain; Region: UTRA; pfam07702 216596003698 Pfam match to entry PF00392.9 GntR, score 63.4,E-value 6.2e-16 216596003699 Predicted helix-turn-helix motif with score 1257.000, SD 3.47 at aa 38-59, sequence SSESELVAAFGVSRMTANRALR 216596003700 Pfam match to entry PF07702.1 UTRA, score 128.3,E-value 1.8e-35 216596003701 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 216596003702 active sites [active] 216596003703 tetramer interface [polypeptide binding]; other site 216596003704 Pfam match to entry PF00221.7 PAL, score 236.2,E-value 5.8e-68 216596003705 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 216596003706 Pfam match to entry PF04069.2 OpuAC, score 253.7,E-value 3.1e-73 216596003707 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 216596003708 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 216596003709 Pfam match to entry PF02423.5 OCD_Mu_crystall, score 150.6, E-value 3.5e-42 216596003710 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 216596003711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596003712 dimer interface [polypeptide binding]; other site 216596003713 conserved gate region; other site 216596003714 putative PBP binding loops; other site 216596003715 ABC-ATPase subunit interface; other site 216596003716 Pfam match to entry PF00528.10 BPD_transp_1, score 85.5, E-value 1.3e-22 216596003717 5 probable transmembrane helices predicted at aa 50-72, 79-101, 106-128,174-196 and 206-228 216596003718 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 216596003719 ABC-ATPase subunit interface; other site 216596003720 Pfam match to entry PF00528.10 BPD_transp_1, score 71.3, E-value 2.5e-18 216596003721 5 probable transmembrane helices predicted at aa 25-47, 54-76, 81-103, 155-177 and 181-203 216596003722 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 216596003723 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 216596003724 Walker A/P-loop; other site 216596003725 ATP binding site [chemical binding]; other site 216596003726 Q-loop/lid; other site 216596003727 ABC transporter signature motif; other site 216596003728 Walker B; other site 216596003729 D-loop; other site 216596003730 H-loop/switch region; other site 216596003731 Pfam match to entry PF00005.11 ABC_tran, score 237.9, E-value 1.9e-68 216596003732 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 216596003733 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 216596003734 ligand binding site [chemical binding]; other site 216596003735 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 216596003736 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 216596003737 Walker A/P-loop; other site 216596003738 ATP binding site [chemical binding]; other site 216596003739 Q-loop/lid; other site 216596003740 ABC transporter signature motif; other site 216596003741 Walker B; other site 216596003742 D-loop; other site 216596003743 H-loop/switch region; other site 216596003744 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 216596003745 Pfam match to entry PF00005.11 ABC_tran, score 172.0, E-value 1.2e-48 216596003746 Pfam match to entry PF00005.11 ABC_tran, score 89.0, E-value 1.2e-23 216596003747 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596003748 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216596003749 TM-ABC transporter signature motif; other site 216596003750 8 probable transmembrane helices predicted at aa 26-48, 53-75, 82-101, 111-133,140-162, 172-194, 225-247 and 277-299 216596003751 Pfam match to entry PF02653.5 BPD_transp_2, score 154.1, E-value 3.1e-43 216596003752 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 216596003753 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 216596003754 DNA binding residues [nucleotide binding] 216596003755 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 216596003756 Predicted helix-turn-helix motif with score 2485.000, SD 7.65 at aa 34-55, sequence LTQAQIADQLGISHATVNRLIK 216596003757 Pfam match to entry PF04198.2 Sugar-bind, score 224.9, E-value 1.5e-64 216596003758 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 216596003759 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 216596003760 active site 216596003761 catalytic tetrad [active] 216596003762 Pfam match to entry PF00248.9 Aldo_ket_red, score 188.9, E-value 1e-53 216596003763 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 216596003764 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 216596003765 Pfam match to entry PF01266.8 DAO, score 157.6,E-value 2.7e-44 216596003766 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 216596003767 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 216596003768 putative active site; other site 216596003769 catalytic residue [active] 216596003770 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 216596003771 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 216596003772 putative N- and C-terminal domain interface [polypeptide binding]; other site 216596003773 putative active site [active] 216596003774 MgATP binding site [chemical binding]; other site 216596003775 catalytic site [active] 216596003776 metal binding site [ion binding]; metal-binding site 216596003777 putative xylulose binding site [chemical binding]; other site 216596003778 Pfam match to entry PF00370.9 FGGY_N, score 248.9, E-value 8.9e-72 216596003779 Pfam match to entry PF02782.4 FGGY_C, score 133.2, E-value 6e-37 216596003780 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 216596003781 lycopene cyclase; Region: lycopene_cycl; TIGR01789 216596003782 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 216596003783 Pfam match to entry PF00732.8 GMC_oxred_N, score 415.8, E-value 5.2e-122 216596003784 Pfam match to entry PF05199.2 GMC_oxred_C, score 160.1, E-value 4.9e-45 216596003785 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 216596003786 DNA-binding site [nucleotide binding]; DNA binding site 216596003787 RNA-binding motif; other site 216596003788 Pfam match to entry PF00313.8 CSD, score 120.7,E-value 3.6e-33 216596003789 3 probable transmembrane helices predicted at aa 29-46, 146-168 and 296-318 216596003790 Methyltransferase domain; Region: Methyltransf_23; pfam13489 216596003791 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596003792 S-adenosylmethionine binding site [chemical binding]; other site 216596003793 AAA ATPase domain; Region: AAA_16; pfam13191 216596003794 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 216596003795 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216596003796 DNA binding residues [nucleotide binding] 216596003797 dimerization interface [polypeptide binding]; other site 216596003798 Pfam match to entry PF00196.8 GerE, score 82.8,E-value 8.7e-22 216596003799 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 216596003800 TAP-like protein; Region: Abhydrolase_4; pfam08386 216596003801 Pfam match to entry PF00561.8 Abhydrolase_1, score 76.7, E-value 6e-20 216596003802 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 216596003803 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596003804 Walker A/P-loop; other site 216596003805 ATP binding site [chemical binding]; other site 216596003806 Q-loop/lid; other site 216596003807 ABC transporter signature motif; other site 216596003808 Walker B; other site 216596003809 D-loop; other site 216596003810 H-loop/switch region; other site 216596003811 Pfam match to entry PF00005.11 ABC_tran, score 217.3, E-value 2.8e-62 216596003812 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 216596003813 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596003814 Walker A/P-loop; other site 216596003815 ATP binding site [chemical binding]; other site 216596003816 Q-loop/lid; other site 216596003817 ABC transporter signature motif; other site 216596003818 Walker B; other site 216596003819 D-loop; other site 216596003820 H-loop/switch region; other site 216596003821 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216596003822 Pfam match to entry PF00005.11 ABC_tran, score 143.9, E-value 3.5e-40 216596003823 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 216596003824 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596003825 dimer interface [polypeptide binding]; other site 216596003826 conserved gate region; other site 216596003827 putative PBP binding loops; other site 216596003828 ABC-ATPase subunit interface; other site 216596003829 Pfam match to entry PF00528.10 BPD_transp_1, score 167.7, E-value 2.4e-47 216596003830 5 probable transmembrane helices predicted at aa 50-72, 114-136, 151-173,234-256 and 276-298 216596003831 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 216596003832 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596003833 dimer interface [polypeptide binding]; other site 216596003834 conserved gate region; other site 216596003835 putative PBP binding loops; other site 216596003836 ABC-ATPase subunit interface; other site 216596003837 Pfam match to entry PF00528.10 BPD_transp_1, score 168.7, E-value 1.2e-47 216596003838 6 probable transmembrane helices predicted at aa 36-58, 130-152, 165-187,226-248, 292-314 and 334-356 216596003839 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 216596003840 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 216596003841 Pfam match to entry PF00496.9 SBP_bac_5, score 61.3, E-value 2.7e-15 216596003842 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 216596003843 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 216596003844 inhibitor site; inhibition site 216596003845 active site 216596003846 dimer interface [polypeptide binding]; other site 216596003847 catalytic residue [active] 216596003848 Pfam match to entry PF00701.10 DHDPS, score 71.9,E-value 1.7e-18 216596003849 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 216596003850 Pfam match to entry PF03758.3 SMP-30, score 241.3, E-value 1.7e-69 216596003851 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 216596003852 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216596003853 NAD(P) binding site [chemical binding]; other site 216596003854 active site 216596003855 Transcriptional regulators [Transcription]; Region: FadR; COG2186 216596003856 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596003857 DNA-binding site [nucleotide binding]; DNA binding site 216596003858 FCD domain; Region: FCD; pfam07729 216596003859 Pfam match to entry PF00392.9 GntR, score 56.0,E-value 1e-13 216596003860 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 216596003861 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 216596003862 Pfam match to entry PF00496.9 SBP_bac_5, score 57.1, E-value 4.7e-14 216596003863 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 216596003864 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596003865 dimer interface [polypeptide binding]; other site 216596003866 conserved gate region; other site 216596003867 putative PBP binding loops; other site 216596003868 ABC-ATPase subunit interface; other site 216596003869 6 probable transmembrane helices predicted at aa 9-31, 107-129, 142-164,192-214, 257-279 and 299-321 216596003870 Pfam match to entry PF00528.10 BPD_transp_1, score 115.6, E-value 1.2e-31 216596003871 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 216596003872 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596003873 dimer interface [polypeptide binding]; other site 216596003874 conserved gate region; other site 216596003875 putative PBP binding loops; other site 216596003876 ABC-ATPase subunit interface; other site 216596003877 6 probable transmembrane helices predicted at aa 33-55, 170-192, 199-221,231-253, 284-306 and 339-361 216596003878 Pfam match to entry PF00528.10 BPD_transp_1, score 122.5, E-value 9.7e-34 216596003879 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 216596003880 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596003881 Walker A/P-loop; other site 216596003882 ATP binding site [chemical binding]; other site 216596003883 Q-loop/lid; other site 216596003884 ABC transporter signature motif; other site 216596003885 Walker B; other site 216596003886 D-loop; other site 216596003887 H-loop/switch region; other site 216596003888 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216596003889 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596003890 Walker A/P-loop; other site 216596003891 ATP binding site [chemical binding]; other site 216596003892 Q-loop/lid; other site 216596003893 ABC transporter signature motif; other site 216596003894 Walker B; other site 216596003895 D-loop; other site 216596003896 H-loop/switch region; other site 216596003897 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216596003898 Pfam match to entry PF00005.11 ABC_tran, score 215.5, E-value 9.9e-62 216596003899 Pfam match to entry PF00005.11 ABC_tran, score 199.8, E-value 5.4e-57 216596003900 galactonate dehydratase; Provisional; Region: PRK14017 216596003901 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 216596003902 active site pocket [active] 216596003903 Pfam match to entry PF02746.4 MR_MLE_N, score 94.0, E-value 3.7e-25 216596003904 Pfam match to entry PF01188.9 MR_MLE, score 143.5, E-value 4.6e-40 216596003905 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 216596003906 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 216596003907 active site pocket [active] 216596003908 Pfam match to entry PF02746.4 MR_MLE_N, score 70.5, E-value 4.4e-18 216596003909 Pfam match to entry PF01188.9 MR_MLE, score 55.1,E-value 2e-13 216596003910 Predicted flavoprotein [General function prediction only]; Region: COG0431 216596003911 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 216596003912 Pfam match to entry PF03358.3 FMN_red, score 88.8, E-value 1.4e-23 216596003913 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 216596003914 putative FMN binding site [chemical binding]; other site 216596003915 Pfam match to entry PF00881.10 Nitroreductase, score 50.5, E-value 4.6e-12 216596003916 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216596003917 dimerization interface [polypeptide binding]; other site 216596003918 putative DNA binding site [nucleotide binding]; other site 216596003919 putative Zn2+ binding site [ion binding]; other site 216596003920 Pfam match to entry PF01022.8 HTH_5, score 89.2,E-value 1.1e-23 216596003921 Predicted helix-turn-helix motif with score 1616.000, SD 4.69 at aa 43-64, sequence MSVSVLADEVGLSQSSTSQHLA 216596003922 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 216596003923 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596003924 active site 216596003925 phosphorylation site [posttranslational modification] 216596003926 intermolecular recognition site; other site 216596003927 dimerization interface [polypeptide binding]; other site 216596003928 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216596003929 DNA binding residues [nucleotide binding] 216596003930 dimerization interface [polypeptide binding]; other site 216596003931 Pfam match to entry PF00196.8 GerE, score 74.7,E-value 2.4e-19 216596003932 Pfam match to entry PF00072.10 Response_reg, score 121.9, E-value 1.5e-33 216596003933 Response regulator receiver domain; Region: Response_reg; pfam00072 216596003934 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596003935 active site 216596003936 phosphorylation site [posttranslational modification] 216596003937 intermolecular recognition site; other site 216596003938 dimerization interface [polypeptide binding]; other site 216596003939 Pfam match to entry PF00072.10 Response_reg, score 83.3, E-value 6.3e-22 216596003940 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 216596003941 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596003942 active site 216596003943 phosphorylation site [posttranslational modification] 216596003944 intermolecular recognition site; other site 216596003945 dimerization interface [polypeptide binding]; other site 216596003946 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216596003947 DNA binding residues [nucleotide binding] 216596003948 dimerization interface [polypeptide binding]; other site 216596003949 Pfam match to entry PF00196.8 GerE, score 74.3,E-value 3.3e-19 216596003950 Predicted helix-turn-helix motif with score 1042.000, SD 2.74 at aa 158-179, sequence LLNKQAAAELGISEVTLQIHRR 216596003951 Pfam match to entry PF00072.10 Response_reg, score 120.7, E-value 3.5e-33 216596003952 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 216596003953 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 216596003954 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216596003955 PAS fold; Region: PAS_3; pfam08447 216596003956 putative active site [active] 216596003957 heme pocket [chemical binding]; other site 216596003958 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 216596003959 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216596003960 putative active site [active] 216596003961 heme pocket [chemical binding]; other site 216596003962 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 216596003963 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216596003964 putative active site [active] 216596003965 heme pocket [chemical binding]; other site 216596003966 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216596003967 putative active site [active] 216596003968 heme pocket [chemical binding]; other site 216596003969 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216596003970 PAS fold; Region: PAS_3; pfam08447 216596003971 putative active site [active] 216596003972 heme pocket [chemical binding]; other site 216596003973 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216596003974 dimer interface [polypeptide binding]; other site 216596003975 phosphorylation site [posttranslational modification] 216596003976 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596003977 ATP binding site [chemical binding]; other site 216596003978 Mg2+ binding site [ion binding]; other site 216596003979 G-X-G motif; other site 216596003980 Pfam match to entry PF02518.9 HATPase_c, score 113.9, E-value 3.8e-31 216596003981 Pfam match to entry PF00512.10 HisKA, score 41.4,E-value 2.6e-09 216596003982 Pfam match to entry PF00785.11 PAC, score 32.3,E-value 1.4e-06 216596003983 Pfam match to entry PF00785.11 PAC, score 41.0,E-value 3.4e-09 216596003984 Pfam match to entry PF00785.11 PAC, score 31.9,E-value 1.9e-06 216596003985 Pfam match to entry PF00785.11 PAC, score 37.4,E-value 4.1e-08 216596003986 Pfam match to entry PF00785.11 PAC, score 38.7,E-value 1.7e-08 216596003987 Pfam match to entry PF05231.4 MASE1, score 280.1,E-value 3.6e-81 216596003988 9 probable transmembrane helices predicted at aa 50-72, 77-94, 101-118,122-144, 164-186, 196-218, 239-261, 276-298 and 310-329 216596003989 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 216596003990 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216596003991 NAD(P) binding site [chemical binding]; other site 216596003992 active site 216596003993 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 216596003994 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 216596003995 DNA binding residues [nucleotide binding] 216596003996 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 216596003997 P-loop; other site 216596003998 Magnesium ion binding site [ion binding]; other site 216596003999 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 216596004000 Magnesium ion binding site [ion binding]; other site 216596004001 Predicted helix-turn-helix motif with score 1547.000, SD 4.46 at aa 46-67, sequence FSLAEVAHYLGVTPSNLKRLYL 216596004002 Pfam match to entry PF00376.9 MerR 216596004003 Pfam match to entry PF00991.7 ParA 216596004004 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 216596004005 ParB-like nuclease domain; Region: ParBc; pfam02195 216596004006 Pfam match to entry PF02195.5 ParBc 216596004007 Pfam match to entry PF07506.1 RepB 216596004008 replication initiation protein RepC; Provisional; Region: PRK13824 216596004009 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216596004010 putative DNA binding site [nucleotide binding]; other site 216596004011 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 216596004012 Pfam match to entry PF03428.3 RP-C 216596004013 Protein of unknown function (DUF972); Region: DUF972; pfam06156 216596004014 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 216596004015 2 probable transmembrane helices predicted at aa 23-45 and 57-79 216596004016 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 216596004017 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 216596004018 substrate-cofactor binding pocket; other site 216596004019 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596004020 catalytic residue [active] 216596004021 Pfam match to entry PF00155.8 Aminotran_1_2 216596004022 Pfam match to entry PF02490.6 ALA_synthase 216596004023 FOG: CBS domain [General function prediction only]; Region: COG0517 216596004024 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 216596004025 Pfam match to entry PF04972.3 BON 216596004026 Pfam match to entry PF00571.13 CBS 216596004027 Pfam match to entry PF00571.13 CBS 216596004028 N-terminal 40 residues are similar to Rhizobium leguminosarum CycK protein SWALL:Q52820 (EMBL:X89726) (664 aa); similarity:fasta; SWALL:Q52820 (EMBL:X89726); Rhizobium leguminosarum; CycK protein; length 664 aa; 40 aa overlap; query 1-40 aa; subject 1-40 aa; putative cycK protein, pseudogene 216596004029 1 probable transmembrane helix predicted at aa 5-27 216596004030 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 216596004031 Pfam match to entry PF03100.4 CcmE 216596004032 1 probable transmembrane helix predicted at aa 7-29 216596004033 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 216596004034 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 216596004035 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 216596004036 Predicted helix-turn-helix motif with score 1488.000, SD 4.25 at aa 176-197, sequence YRKRILAGKLGLAPEALSRAFA 216596004037 Pfam match to entry PF00027.13 cNMP_binding 216596004038 cytochrome oxidase maturation protein, cbb3-type; Region: ccoS; TIGR00847 216596004039 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 216596004040 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 216596004041 metal-binding site [ion binding] 216596004042 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 216596004043 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 216596004044 6 probable transmembrane helices predicted at aa 122-144, 154-176, 368-390,400-422, 695-714 and 718-740 216596004045 Pfam match to entry PF00702.10 Hydrolase 216596004046 Pfam match to entry PF00122.7 E1-E2_ATPase 216596004047 Pfam match to entry PF00403.12 HMA 216596004048 Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456 216596004049 FixH; Region: FixH; pfam05751 216596004050 Pfam match to entry PF05751.1 FixH 216596004051 1 probable transmembrane helix predicted at aa 13-35 216596004052 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 216596004053 4Fe-4S binding domain; Region: Fer4_5; pfam12801 216596004054 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 216596004055 5 probable transmembrane helices predicted at aa 50-68, 100-122, 174-191,206-228 and 382-401 216596004056 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 216596004057 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 216596004058 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 216596004059 Pfam match to entry PF00034.8 Cytochrom_C 216596004060 Pfam match to entry PF00034.8 Cytochrom_C 216596004061 1 probable transmembrane helix predicted at aa 35-57 216596004062 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 216596004063 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 216596004064 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 216596004065 Pfam match to entry PF02433.5 FixO 216596004066 1 probable transmembrane helix predicted at aa 17-39 216596004067 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 216596004068 Low-spin heme binding site [chemical binding]; other site 216596004069 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 216596004070 Putative water exit pathway; other site 216596004071 Binuclear center (active site) [active] 216596004072 Putative proton exit pathway; other site 216596004073 14 probable transmembrane helices predicted at aa 7-24, 29-51, 74-96, 116-138,150-172, 185-207, 220-242, 262-284, 293-315, 330-352,365-387, 402-424, 441-463 and 493-515 216596004074 Pfam match to entry PF00115.8 COX1 216596004075 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 216596004076 ligand binding site [chemical binding]; other site 216596004077 flexible hinge region; other site 216596004078 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 216596004079 putative switch regulator; other site 216596004080 non-specific DNA interactions [nucleotide binding]; other site 216596004081 DNA binding site [nucleotide binding] 216596004082 sequence specific DNA binding site [nucleotide binding]; other site 216596004083 putative cAMP binding site [chemical binding]; other site 216596004084 Pfam match to entry PF00027.13 cNMP_binding 216596004085 Pfam match to entry PF00325.9 Crp 216596004086 Predicted helix-turn-helix motif with score 2040.000, SD 6.13 at aa 187-208, sequence MSRQDIADHLGLTIETVSRTLT 216596004087 PAS domain; Region: PAS_9; pfam13426 216596004088 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216596004089 putative active site [active] 216596004090 heme pocket [chemical binding]; other site 216596004091 PAS domain S-box; Region: sensory_box; TIGR00229 216596004092 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216596004093 putative active site [active] 216596004094 heme pocket [chemical binding]; other site 216596004095 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216596004096 dimer interface [polypeptide binding]; other site 216596004097 phosphorylation site [posttranslational modification] 216596004098 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596004099 ATP binding site [chemical binding]; other site 216596004100 Mg2+ binding site [ion binding]; other site 216596004101 G-X-G motif; other site 216596004102 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596004103 active site 216596004104 phosphorylation site [posttranslational modification] 216596004105 intermolecular recognition site; other site 216596004106 dimerization interface [polypeptide binding]; other site 216596004107 Pfam match to entry PF00989.11 PAS 216596004108 Pfam match to entry PF00989.11 PAS 216596004109 Pfam match to entry PF00512.10 HisKA 216596004110 Pfam match to entry PF02518.9 HATPase_c 216596004111 Pfam match to entry PF00072.9 Response_reg 216596004112 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 216596004113 pseudoazurin; Region: pseudoazurin; TIGR02375 216596004114 1 probable transmembrane helix predicted at aa 5-24 216596004115 Pfam match to entry PF00127.8 Copper-bind 216596004116 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 216596004117 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 216596004118 FeS/SAM binding site; other site 216596004119 HemN C-terminal domain; Region: HemN_C; pfam06969 216596004120 Pfam match to entry PF06969.2 HemN_C 216596004121 Pfam match to entry PF04055.4 Radical_SAM 216596004122 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 216596004123 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 216596004124 ligand binding site [chemical binding]; other site 216596004125 flexible hinge region; other site 216596004126 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 216596004127 putative switch regulator; other site 216596004128 non-specific DNA interactions [nucleotide binding]; other site 216596004129 DNA binding site [nucleotide binding] 216596004130 sequence specific DNA binding site [nucleotide binding]; other site 216596004131 putative cAMP binding site [chemical binding]; other site 216596004132 Pfam match to entry PF00325.9 Crp 216596004133 Predicted helix-turn-helix motif with score 1724.000, SD 5.06 at aa 179-200, sequence MTRLDIADYLGLTIETVSRMMT 216596004134 Pfam match to entry PF00027.13 cNMP_binding 216596004135 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 216596004136 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596004137 active site 216596004138 phosphorylation site [posttranslational modification] 216596004139 intermolecular recognition site; other site 216596004140 dimerization interface [polypeptide binding]; other site 216596004141 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216596004142 DNA binding site [nucleotide binding] 216596004143 Pfam match to entry PF00072.9 Response_reg 216596004144 Pfam match to entry PF00486.11 Trans_reg_C 216596004145 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 216596004146 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 216596004147 NAD binding site [chemical binding]; other site 216596004148 substrate binding site [chemical binding]; other site 216596004149 catalytic Zn binding site [ion binding]; other site 216596004150 tetramer interface [polypeptide binding]; other site 216596004151 structural Zn binding site [ion binding]; other site 216596004152 Pfam match to entry PF00107.10 ADH_zinc_N 216596004153 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 216596004154 FOG: CBS domain [General function prediction only]; Region: COG0517 216596004155 BON domain; Region: BON; pfam04972 216596004156 Pfam match to entry PF00571.13 CBS 216596004157 Pfam match to entry PF00571.13 CBS 216596004158 Pfam match to entry PF04972.3 BON 216596004159 1 probable transmembrane helix predicted at aa 10-29 216596004160 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 216596004161 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 216596004162 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 216596004163 Pfam match to entry PF02550.4 AcetylCoA_hydro 216596004164 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 216596004165 Ligand Binding Site [chemical binding]; other site 216596004166 Pfam match to entry PF00582.12 Usp 216596004167 ribosome small subunit-dependent GTPase A; Region: TIGR00157 216596004168 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 216596004169 GTPase/Zn-binding domain interface [polypeptide binding]; other site 216596004170 GTP/Mg2+ binding site [chemical binding]; other site 216596004171 G4 box; other site 216596004172 G5 box; other site 216596004173 G1 box; other site 216596004174 Switch I region; other site 216596004175 G2 box; other site 216596004176 G3 box; other site 216596004177 Switch II region; other site 216596004178 Pfam match to entry PF03193.4 DUF258 216596004179 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 216596004180 Protein required for attachment to host cells; Region: Host_attach; cl02398 216596004181 similarity:fasta; SWALL:CYSQ_ECOLI (SWALL:P22255); Escherichia coli; cysq protein; CysQ or AmtA or b4214; length 246 aa; 248 aa overlap; query 9-250 aa; subject 1-241 aa; similarity:fasta; SWALL:CYSQ_BUCAI (SWALL:P57624); Buchnera aphidicola; cysq protein homolog; CysQ or bu561; length 265 aa; 257 aa overlap; query 7-253 aa; subject 15-263 aa; putative cysteine synthesis CysQ protein,pseudogene 216596004182 Pfam match to entry PF00459.10 Inositol_P 216596004183 Pfam match to entry PF00459.10 Inositol_P 216596004184 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 216596004185 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 216596004186 AAA domain; Region: AAA_33; pfam13671 216596004187 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 216596004188 active site 216596004189 similarity:fasta; SWALL:Q92Z69 (EMBL:AE007252); Rhizobium meliloti; hypothetical protein ra0623; name=sma1153; orderedlocusnames=ra0623; length 224 aa; 168 aa overlap; query 10-176 aa; subject 48-215 aa 216596004190 chaperonin GroEL; Reviewed; Region: groEL; PRK12851 216596004191 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 216596004192 ring oligomerisation interface [polypeptide binding]; other site 216596004193 ATP/Mg binding site [chemical binding]; other site 216596004194 stacking interactions; other site 216596004195 hinge regions; other site 216596004196 Pfam match to entry PF00118.12 Cpn60_TCP1 216596004197 submitted without /pseudo; similarity:fasta; SWALL:Q92Z69 (EMBL:AE007252); Rhizobium meliloti; hypothetical protein ra0623; name=sma1153; orderedlocusnames=ra0623; length 224 aa; 208 aa overlap; query 19-221 aa; subject 6-212 aa 216596004198 Pfam match to entry PF04972.3 BON 216596004199 Pfam match to entry PF04972.3 BON 216596004200 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 216596004201 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 216596004202 HlyD family secretion protein; Region: HlyD_3; pfam13437 216596004203 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 216596004204 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 216596004205 Walker A/P-loop; other site 216596004206 ATP binding site [chemical binding]; other site 216596004207 Q-loop/lid; other site 216596004208 ABC transporter signature motif; other site 216596004209 Walker B; other site 216596004210 D-loop; other site 216596004211 H-loop/switch region; other site 216596004212 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216596004213 Walker A/P-loop; other site 216596004214 ATP binding site [chemical binding]; other site 216596004215 Q-loop/lid; other site 216596004216 ABC transporter signature motif; other site 216596004217 Walker B; other site 216596004218 D-loop; other site 216596004219 H-loop/switch region; other site 216596004220 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 216596004221 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 216596004222 Pfam match to entry PF00005.11 ABC_tran 216596004223 Pfam match to entry PF00005.11 ABC_tran 216596004224 5 probable transmembrane helices predicted at aa 712-734, 755-777, 792-814,821-843 and 879-901 216596004225 Pfam match to entry PF01061.8 ABC2_membrane 216596004226 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 216596004227 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 216596004228 6 probable transmembrane helices predicted at aa 16-38, 176-198, 229-251,255-277, 284-306 and 343-365 216596004229 Pfam match to entry PF01061.8 ABC2_membrane 216596004230 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 216596004231 Ligand Binding Site [chemical binding]; other site 216596004232 Pfam match to entry PF00582.12 Usp 216596004233 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; cl17869 216596004234 Bacterial sugar transferase; Region: Bac_transf; pfam02397 216596004235 Pfam match to entry PF02397.6 Bac_transf 216596004236 1 probable transmembrane helix predicted at aa 146-168 216596004237 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 216596004238 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 216596004239 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 216596004240 NAD(P) binding site [chemical binding]; other site 216596004241 homodimer interface [polypeptide binding]; other site 216596004242 substrate binding site [chemical binding]; other site 216596004243 active site 216596004244 5 probable transmembrane helices predicted at aa 21-40, 55-77, 84-106, 116-138 and 151-168 216596004245 Pfam match to entry PF02719.4 Polysacc_synt_2 216596004246 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 216596004247 O-Antigen ligase; Region: Wzy_C; pfam04932 216596004248 8 probable transmembrane helices predicted at aa 54-76, 83-100, 134-156,168-190, 200-222, 242-264, 344-366 and 379-401 216596004249 Pfam match to entry PF04932.3 Wzy_C 216596004250 1 probable transmembrane helix predicted at aa 67-89 216596004251 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 216596004252 Transcriptional regulators [Transcription]; Region: GntR; COG1802 216596004253 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596004254 DNA-binding site [nucleotide binding]; DNA binding site 216596004255 FCD domain; Region: FCD; pfam07729 216596004256 Pfam match to entry PF00392.9 GntR 216596004257 mannonate dehydratase; Provisional; Region: PRK03906 216596004258 mannonate dehydratase; Region: uxuA; TIGR00695 216596004259 Pfam match to entry PF03786.3 UxuA 216596004260 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216596004261 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216596004262 Pfam match to entry PF00440.8 TetR_N 216596004263 Predicted helix-turn-helix motif with score 1676.000, SD 4.90 at aa 43-64, sequence ASIATIAQEAGVSTKTLYRLFP 216596004264 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 216596004265 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 216596004266 HlyD family secretion protein; Region: HlyD_3; pfam13437 216596004267 1 probable transmembrane helix predicted at aa 55-77 216596004268 Pfam match to entry PF00529.8 HlyD 216596004269 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 216596004270 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596004271 putative substrate translocation pore; other site 216596004272 11 probable transmembrane helices predicted at aa 23-45, 60-82, 116-138, 148-170,177-199, 214-231, 244-266, 281-303, 346-365, 380-402 and 492-514 216596004273 Pfam match to entry PF07690.1 MFS_1 216596004274 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 216596004275 active site 216596004276 catalytic residues [active] 216596004277 Pfam match to entry PF01263.8 Aldose_epim 216596004278 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 216596004279 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 216596004280 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216596004281 Walker A/P-loop; other site 216596004282 ATP binding site [chemical binding]; other site 216596004283 Q-loop/lid; other site 216596004284 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 216596004285 ABC transporter signature motif; other site 216596004286 Walker B; other site 216596004287 D-loop; other site 216596004288 ABC transporter; Region: ABC_tran_2; pfam12848 216596004289 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 216596004290 Pfam match to entry PF00005.11 ABC_tran 216596004291 Pfam match to entry PF00005.11 ABC_tran 216596004292 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216596004293 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 216596004294 active site 216596004295 Pfam match to entry PF00903.11 Glyoxalase 216596004296 1 probable transmembrane helix predicted at aa 129-148 216596004297 2 probable transmembrane helices predicted at aa 2-24 and 28-50 216596004298 Pfam match to entry PF07043.1 DUF1328 216596004299 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 216596004300 Ca2+ binding site [ion binding]; other site 216596004301 Pfam match to entry PF00036.15 efhand 216596004302 Pfam match to entry PF00036.15 efhand 216596004303 2 probable transmembrane helices predicted at aa 35-57 and 62-81 216596004304 Protein of unknown function (DUF992); Region: DUF992; pfam06186 216596004305 Pfam match to entry PF06186.1 DUF992 216596004306 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 216596004307 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216596004308 Coenzyme A binding pocket [chemical binding]; other site 216596004309 Pfam match to entry PF00583.9 Acetyltransf_1 216596004310 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 216596004311 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596004312 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216596004313 dimerization interface [polypeptide binding]; other site 216596004314 Pfam match to entry PF03466.5 LysR_substrate 216596004315 Pfam match to entry PF00126.10 HTH_1 216596004316 Predicted helix-turn-helix motif with score 1436.000, SD 4.08 at aa 24-45, sequence GSFSAAAAESGITHGAVSRQVS 216596004317 EamA-like transporter family; Region: EamA; pfam00892 216596004318 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 216596004319 EamA-like transporter family; Region: EamA; pfam00892 216596004320 10 probable transmembrane helices predicted at aa 23-45, 55-74, 83-100, 110-132,139-158, 168-185, 192-214, 229-248, 261-278 and 282-301 216596004321 Pfam match to entry PF00892.8 DUF6 216596004322 Pfam match to entry PF00892.8 DUF6 216596004323 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 216596004324 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 216596004325 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 216596004326 Pfam match to entry PF00455.10 DeoR 216596004327 Predicted helix-turn-helix motif with score 1178.000, SD 3.20 at aa 20-41, sequence VLVEELASRFSVTPQTIRKDLN 216596004328 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 216596004329 Pfam match to entry PF01266.8 DAO 216596004330 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 216596004331 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 216596004332 Walker A/P-loop; other site 216596004333 ATP binding site [chemical binding]; other site 216596004334 Q-loop/lid; other site 216596004335 ABC transporter signature motif; other site 216596004336 Walker B; other site 216596004337 D-loop; other site 216596004338 H-loop/switch region; other site 216596004339 Pfam match to entry PF00005.11 ABC_tran 216596004340 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 216596004341 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 216596004342 Walker A/P-loop; other site 216596004343 ATP binding site [chemical binding]; other site 216596004344 Q-loop/lid; other site 216596004345 ABC transporter signature motif; other site 216596004346 Walker B; other site 216596004347 D-loop; other site 216596004348 H-loop/switch region; other site 216596004349 TOBE domain; Region: TOBE_2; pfam08402 216596004350 Pfam match to entry PF00005.11 ABC_tran 216596004351 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596004352 dimer interface [polypeptide binding]; other site 216596004353 conserved gate region; other site 216596004354 putative PBP binding loops; other site 216596004355 ABC-ATPase subunit interface; other site 216596004356 6 probable transmembrane helices predicted at aa 9-31, 70-89, 102-124, 160-179,208-230 and 256-278 216596004357 Pfam match to entry PF00528.10 BPD_transp_1 216596004358 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216596004359 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596004360 dimer interface [polypeptide binding]; other site 216596004361 conserved gate region; other site 216596004362 putative PBP binding loops; other site 216596004363 ABC-ATPase subunit interface; other site 216596004364 6 probable transmembrane helices predicted at aa 9-31, 73-95, 107-129, 139-161,182-204 and 238-260 216596004365 Pfam match to entry PF00528.10 BPD_transp_1 216596004366 Predicted small integral membrane protein (DUF2160); Region: DUF2160; cl02294 216596004367 3 probable transmembrane helices predicted at aa 10-32, 53-70 and 75-92 216596004368 Signal peptide predicted for pRL90080 by SignalP 2.0 HMM (Signal peptide probabilty 0.987) with cleavage site probability 0.880 between residues 42 and 43 216596004369 1 probable transmembrane helix predicted at aa 20-42 216596004370 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 216596004371 Pfam match to entry PF01547.11 SBP_bac_1 216596004372 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 216596004373 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 216596004374 N- and C-terminal domain interface [polypeptide binding]; other site 216596004375 active site 216596004376 MgATP binding site [chemical binding]; other site 216596004377 catalytic site [active] 216596004378 metal binding site [ion binding]; metal-binding site 216596004379 glycerol binding site [chemical binding]; other site 216596004380 homotetramer interface [polypeptide binding]; other site 216596004381 homodimer interface [polypeptide binding]; other site 216596004382 FBP binding site [chemical binding]; other site 216596004383 protein IIAGlc interface [polypeptide binding]; other site 216596004384 Pfam match to entry PF00370.9 FGGY_N 216596004385 Pfam match to entry PF02782.4 FGGY_C 216596004386 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596004387 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216596004388 TM-ABC transporter signature motif; other site 216596004389 9 probable transmembrane helices predicted at aa 20-40, 53-75, 90-112, 119-141,175-197, 226-248, 258-277, 282-301 and 306-325 216596004390 Pfam match to entry PF02653.5 BPD_transp_2 216596004391 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216596004392 TM-ABC transporter signature motif; other site 216596004393 10 probable transmembrane helices predicted at aa 47-69, 79-101, 108-130,134-156, 158-180, 200-222, 249-271, 275-297, 304-326 and 330-349 216596004394 Pfam match to entry PF02653.5 BPD_transp_2 216596004395 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 216596004396 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 216596004397 Walker A/P-loop; other site 216596004398 ATP binding site [chemical binding]; other site 216596004399 Q-loop/lid; other site 216596004400 ABC transporter signature motif; other site 216596004401 Walker B; other site 216596004402 D-loop; other site 216596004403 H-loop/switch region; other site 216596004404 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 216596004405 Pfam match to entry PF00005.11 ABC_tran 216596004406 Pfam match to entry PF00005.11 ABC_tran 216596004407 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 216596004408 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 216596004409 putative ligand binding site [chemical binding]; other site 216596004410 Pfam match to entry PF00532.8 Peripla_BP_1 216596004411 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 216596004412 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216596004413 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216596004414 Pfam match to entry PF00165.8 HTH_AraC 216596004415 Predicted helix-turn-helix motif with score 1010.000, SD 2.63 at aa 234-255, sequence LSVEELAGVAHMSPFHFSREFK 216596004416 Pfam match to entry PF00165.8 HTH_AraC 216596004417 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 216596004418 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216596004419 active site 216596004420 Pfam match to entry PF00903.11 Glyoxalase 216596004421 NMT1/THI5 like; Region: NMT1; pfam09084 216596004422 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 216596004423 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 216596004424 membrane-bound complex binding site; other site 216596004425 hinge residues; other site 216596004426 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 216596004427 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 216596004428 Walker A/P-loop; other site 216596004429 ATP binding site [chemical binding]; other site 216596004430 Q-loop/lid; other site 216596004431 ABC transporter signature motif; other site 216596004432 Walker B; other site 216596004433 D-loop; other site 216596004434 H-loop/switch region; other site 216596004435 Pfam match to entry PF00005.11 ABC_tran 216596004436 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 216596004437 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 216596004438 6 probable transmembrane helices predicted at aa 7-29, 65-87, 100-122, 127-149,181-203 and 223-242 216596004439 Pfam match to entry PF00528.10 BPD_transp_1 216596004440 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 216596004441 active site 216596004442 dimer interface [polypeptide binding]; other site 216596004443 motif 2; other site 216596004444 motif 3; other site 216596004445 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 216596004446 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 216596004447 Uncharacterized conserved protein [Function unknown]; Region: COG5654 216596004448 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 216596004449 oligomeric interface; other site 216596004450 putative active site [active] 216596004451 homodimer interface [polypeptide binding]; other site 216596004452 Pfam match to entry PF01850.8 PIN 216596004453 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 216596004454 Pfam match to entry PF02604.5 PhdYeFM 216596004455 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 216596004456 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 216596004457 Pfam match to entry PF04166.2 PdxA 216596004458 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 216596004459 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 216596004460 putative active site [active] 216596004461 metal binding site [ion binding]; metal-binding site 216596004462 Pfam match to entry PF00465.7 Fe-ADH 216596004463 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 216596004464 BNR repeat-like domain; Region: BNR_2; pfam13088 216596004465 Pfam match to entry PF02012.7 BNR 216596004466 Pfam match to entry PF02012.7 BNR 216596004467 Pfam match to entry PF02012.7 BNR 216596004468 Pfam match to entry PF02012.7 BNR 216596004469 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 216596004470 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 216596004471 inhibitor site; inhibition site 216596004472 active site 216596004473 dimer interface [polypeptide binding]; other site 216596004474 catalytic residue [active] 216596004475 Pfam match to entry PF00701.10 DHDPS 216596004476 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 216596004477 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 216596004478 1 probable transmembrane helix predicted at aa 36-58 216596004479 Pfam match to entry PF00496.9 SBP_bac_5 216596004480 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 216596004481 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596004482 dimer interface [polypeptide binding]; other site 216596004483 conserved gate region; other site 216596004484 putative PBP binding loops; other site 216596004485 ABC-ATPase subunit interface; other site 216596004486 6 probable transmembrane helices predicted at aa 12-34, 106-128, 141-163,178-200, 241-263 and 283-302 216596004487 Pfam match to entry PF00528.10 BPD_transp_1 216596004488 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 216596004489 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 216596004490 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596004491 dimer interface [polypeptide binding]; other site 216596004492 conserved gate region; other site 216596004493 putative PBP binding loops; other site 216596004494 ABC-ATPase subunit interface; other site 216596004495 6 probable transmembrane helices predicted at aa 31-53, 98-120, 127-149,176-198, 229-251 and 283-305 216596004496 Pfam match to entry PF00528.10 BPD_transp_1 216596004497 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 216596004498 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596004499 Walker A/P-loop; other site 216596004500 ATP binding site [chemical binding]; other site 216596004501 Q-loop/lid; other site 216596004502 ABC transporter signature motif; other site 216596004503 Walker B; other site 216596004504 D-loop; other site 216596004505 H-loop/switch region; other site 216596004506 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 216596004507 Pfam match to entry PF00005.11 ABC_tran 216596004508 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 216596004509 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596004510 Walker A/P-loop; other site 216596004511 ATP binding site [chemical binding]; other site 216596004512 Q-loop/lid; other site 216596004513 ABC transporter signature motif; other site 216596004514 Walker B; other site 216596004515 D-loop; other site 216596004516 H-loop/switch region; other site 216596004517 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 216596004518 Pfam match to entry PF00005.11 ABC_tran 216596004519 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 216596004520 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 216596004521 Transcriptional regulators [Transcription]; Region: FadR; COG2186 216596004522 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596004523 DNA-binding site [nucleotide binding]; DNA binding site 216596004524 FCD domain; Region: FCD; pfam07729 216596004525 Pfam match to entry PF00392.9 GntR 216596004526 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 216596004527 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596004528 S-adenosylmethionine binding site [chemical binding]; other site 216596004529 Pfam match to entry PF01135.8 PCMT 216596004530 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 216596004531 DNA binding residues [nucleotide binding] 216596004532 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 216596004533 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 216596004534 Pfam match to entry PF04198.2 Sugar-bind 216596004535 Predicted helix-turn-helix motif with score 1397.000, SD 3.94 at aa 32-53, sequence RTQGEIAEALSTNRLRVNKIIA 216596004536 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 216596004537 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 216596004538 Walker A/P-loop; other site 216596004539 ATP binding site [chemical binding]; other site 216596004540 Q-loop/lid; other site 216596004541 ABC transporter signature motif; other site 216596004542 Walker B; other site 216596004543 D-loop; other site 216596004544 H-loop/switch region; other site 216596004545 Pfam match to entry PF00005.11 ABC_tran 216596004546 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 216596004547 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 216596004548 Pfam match to entry PF01547.11 SBP_bac_1 216596004549 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 216596004550 6 probable transmembrane helices predicted at aa 63-85, 124-146, 159-181,225-242, 254-276 and 317-339 216596004551 Pfam match to entry PF00528.10 BPD_transp_1 216596004552 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216596004553 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596004554 dimer interface [polypeptide binding]; other site 216596004555 conserved gate region; other site 216596004556 putative PBP binding loops; other site 216596004557 ABC-ATPase subunit interface; other site 216596004558 7 probable transmembrane helices predicted at aa 7-29, 76-98, 105-124, 139-158,170-192, 216-238 and 271-293 216596004559 Pfam match to entry PF00528.10 BPD_transp_1 216596004560 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 216596004561 Glycerophosphodiester phosphodiesterase domain of putative Agrobacterium tumefaciens glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_pAtGDE_like; cd08565 216596004562 active site 216596004563 catalytic site [active] 216596004564 metal binding site [ion binding]; metal-binding site 216596004565 Pfam match to entry PF03009.6 GDPD 216596004566 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216596004567 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 216596004568 active site 216596004569 motif I; other site 216596004570 motif II; other site 216596004571 Pfam match to entry PF00702.10 Hydrolase 216596004572 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 216596004573 classical (c) SDRs; Region: SDR_c; cd05233 216596004574 NAD(P) binding site [chemical binding]; other site 216596004575 active site 216596004576 Pfam match to entry PF00106.11 adh_short 216596004577 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 216596004578 FGGY-family pentulose kinase; Region: 5C_CHO_kinase; TIGR01315 216596004579 N- and C-terminal domain interface [polypeptide binding]; other site 216596004580 active site 216596004581 MgATP binding site [chemical binding]; other site 216596004582 catalytic site [active] 216596004583 metal binding site [ion binding]; metal-binding site 216596004584 carbohydrate binding site [chemical binding]; other site 216596004585 putative homodimer interface [polypeptide binding]; other site 216596004586 Pfam match to entry PF00370.9 FGGY_N 216596004587 Pfam match to entry PF02782.4 FGGY_C 216596004588 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 216596004589 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 216596004590 Pfam match to entry PF03734.4 ErfK_YbiS_YhnG 216596004591 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596004592 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596004593 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 216596004594 putative effector binding pocket; other site 216596004595 putative dimerization interface [polypeptide binding]; other site 216596004596 Pfam match to entry PF03466.5 LysR_substrate 216596004597 Pfam match to entry PF00126.10 HTH_1 216596004598 Predicted helix-turn-helix motif with score 1914.000, SD 5.71 at aa 18-39, sequence KSFRGAAERLGLSHSAVSQAIR 216596004599 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 216596004600 Pfam match to entry PF02627.6 CMD 216596004601 Predicted ATPase [General function prediction only]; Region: COG4637 216596004602 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216596004603 Walker A/P-loop; other site 216596004604 ATP binding site [chemical binding]; other site 216596004605 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216596004606 Q-loop/lid; other site 216596004607 ABC transporter signature motif; other site 216596004608 Walker B; other site 216596004609 D-loop; other site 216596004610 H-loop/switch region; other site 216596004611 Transcriptional regulators [Transcription]; Region: PurR; COG1609 216596004612 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216596004613 DNA binding site [nucleotide binding] 216596004614 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 216596004615 putative dimerization interface [polypeptide binding]; other site 216596004616 putative ligand binding site [chemical binding]; other site 216596004617 Pfam match to entry PF00532.8 Peripla_BP_1 216596004618 Pfam match to entry PF00356.8 LacI 216596004619 Predicted helix-turn-helix motif with score 1817.000, SD 5.38 at aa 10-31, sequence PTMSDIAAACGVSQATVSLVLN 216596004620 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 216596004621 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 216596004622 Walker A/P-loop; other site 216596004623 ATP binding site [chemical binding]; other site 216596004624 Q-loop/lid; other site 216596004625 ABC transporter signature motif; other site 216596004626 Walker B; other site 216596004627 D-loop; other site 216596004628 H-loop/switch region; other site 216596004629 TOBE domain; Region: TOBE_2; pfam08402 216596004630 Pfam match to entry PF00005.11 ABC_tran 216596004631 Pfam match to entry PF03459.4 TOBE 216596004632 Pfam match to entry PF03459.4 TOBE 216596004633 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 216596004634 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596004635 dimer interface [polypeptide binding]; other site 216596004636 conserved gate region; other site 216596004637 putative PBP binding loops; other site 216596004638 ABC-ATPase subunit interface; other site 216596004639 6 probable transmembrane helices predicted at aa 13-35, 79-101, 113-135,164-186, 212-234 and 268-290 216596004640 Pfam match to entry PF00528.10 BPD_transp_1 216596004641 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216596004642 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596004643 dimer interface [polypeptide binding]; other site 216596004644 conserved gate region; other site 216596004645 putative PBP binding loops; other site 216596004646 ABC-ATPase subunit interface; other site 216596004647 6 probable transmembrane helices predicted at aa 16-38, 81-103, 112-134,144-166, 187-209 and 246-268 216596004648 Pfam match to entry PF00528.10 BPD_transp_1 216596004649 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 216596004650 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 216596004651 Pfam match to entry PF01547.11 SBP_bac_1 216596004652 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 216596004653 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 216596004654 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 216596004655 Pfam match to entry PF02837.6 Glyco_hydro_2_N 216596004656 Pfam match to entry PF00703.9 Glyco_hydro_2 216596004657 Pfam match to entry PF02836.5 Glyco_hydro_2_C 216596004658 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 216596004659 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 216596004660 catalytic site [active] 216596004661 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 216596004662 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216596004663 DNA binding residues [nucleotide binding] 216596004664 dimerization interface [polypeptide binding]; other site 216596004665 Pfam match to entry PF00561.8 Abhydrolase_1 216596004666 Pfam match to entry PF00196.8 GerE 216596004667 Predicted helix-turn-helix motif with score 1224.000, SD 3.36 at aa 291-312, sequence LDNRAIAERLGKSAKTVRNQLS 216596004668 Methyltransferase domain; Region: Methyltransf_31; pfam13847 216596004669 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596004670 S-adenosylmethionine binding site [chemical binding]; other site 216596004671 Flagellin N-methylase; Region: FliB; cl00497 216596004672 PFAM match to entry UPF0153, E-value 2.30e-04 216596004673 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 216596004674 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 216596004675 NADP binding site [chemical binding]; other site 216596004676 active site 216596004677 putative substrate binding site [chemical binding]; other site 216596004678 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 216596004679 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 216596004680 NADP-binding site; other site 216596004681 homotetramer interface [polypeptide binding]; other site 216596004682 substrate binding site [chemical binding]; other site 216596004683 homodimer interface [polypeptide binding]; other site 216596004684 active site 216596004685 Pfam match to entry PF01370.8 Epimerase 216596004686 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 216596004687 AAA domain; Region: AAA_31; pfam13614 216596004688 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 216596004689 2 probable transmembrane helices predicted at aa 44-66 and 449-471 216596004690 Pfam match to entry PF02706.5 Wzz 216596004691 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 216596004692 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 216596004693 Pfam match to entry PF00534.8 Glycos_transf_1 216596004694 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 216596004695 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 216596004696 Pfam match to entry PF00534.8 Glycos_transf_1 216596004697 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 216596004698 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 216596004699 active site 216596004700 Pfam match to entry PF00535.10 Glycos_transf_2 216596004701 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 216596004702 O-Antigen ligase; Region: Wzy_C; pfam04932 216596004703 11 probable transmembrane helices predicted at aa 21-43, 53-71, 84-103, 107-126,133-155, 170-192, 204-238, 248-270, 339-358, 373-395 and 400-422 216596004704 Pfam match to entry PF04932.3 Wzy_C 216596004705 Right handed beta helix region; Region: Beta_helix; pfam13229 216596004706 Right handed beta helix region; Region: Beta_helix; pfam13229 216596004707 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 216596004708 Pfam match to entry PF00353.8 HemolysinCabind 216596004709 Pfam match to entry PF00353.8 HemolysinCabind 216596004710 Pfam match to entry PF00353.8 HemolysinCabind 216596004711 Pfam match to entry PF00353.8 HemolysinCabind 216596004712 Pfam match to entry PF00353.8 HemolysinCabind 216596004713 Pfam match to entry PF00353.8 HemolysinCabind 216596004714 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 216596004715 Pfam match to entry PF01609.9 Transposase_11 216596004716 1 probable transmembrane helix predicted at aa 54-71 216596004717 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 216596004718 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 216596004719 Pfam match to entry PF03808.3 Glyco_tran_WecB 216596004720 Undecaprenyl-phosphate galactose phosphotransferase, WbaP; Region: WbaP_sugtrans; TIGR03022 216596004721 Bacterial sugar transferase; Region: Bac_transf; pfam02397 216596004722 5 probable transmembrane helices predicted at aa 81-103, 113-135, 148-165,170-192 and 319-341 216596004723 Pfam match to entry PF02397.6 Bac_transf 216596004724 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 216596004725 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 216596004726 NAD binding site [chemical binding]; other site 216596004727 putative substrate binding site 2 [chemical binding]; other site 216596004728 putative substrate binding site 1 [chemical binding]; other site 216596004729 active site 216596004730 Pfam match to entry PF01370.8 Epimerase 216596004731 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 216596004732 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216596004733 binding surface 216596004734 TPR repeat; Region: TPR_11; pfam13414 216596004735 TPR motif; other site 216596004736 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 216596004737 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216596004738 DNA binding residues [nucleotide binding] 216596004739 dimerization interface [polypeptide binding]; other site 216596004740 Pfam match to entry PF00196.8 GerE 216596004741 Pfam match to entry PF00132.9 Hexapep 216596004742 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 216596004743 putative trimer interface [polypeptide binding]; other site 216596004744 putative active site [active] 216596004745 putative substrate binding site [chemical binding]; other site 216596004746 putative CoA binding site [chemical binding]; other site 216596004747 Pfam match to entry PF00132.9 Hexapep 216596004748 Pfam match to entry PF00132.9 Hexapep 216596004749 Pfam match to entry PF00132.9 Hexapep 216596004750 Pfam match to entry PF00132.9 Hexapep 216596004751 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 216596004752 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 216596004753 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 216596004754 Pfam match to entry PF01408.8 GFO_IDH_MocA 216596004755 Pfam match to entry PF02894.4 GFO_IDH_MocA_C 216596004756 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 216596004757 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 216596004758 inhibitor-cofactor binding pocket; inhibition site 216596004759 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596004760 catalytic residue [active] 216596004761 Pfam match to entry PF01041.7 DegT_DnrJ_EryC1 216596004762 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 216596004763 putative trimer interface [polypeptide binding]; other site 216596004764 putative CoA binding site [chemical binding]; other site 216596004765 Pfam match to entry PF00132.9 Hexapep 216596004766 Pfam match to entry PF00132.9 Hexapep 216596004767 Pfam match to entry PF00132.9 Hexapep 216596004768 Pfam match to entry PF00132.9 Hexapep 216596004769 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 216596004770 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216596004771 NAD(P) binding site [chemical binding]; other site 216596004772 active site 216596004773 Pfam match to entry PF01370.8 Epimerase 216596004774 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 216596004775 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 216596004776 inhibitor-cofactor binding pocket; inhibition site 216596004777 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596004778 catalytic residue [active] 216596004779 Pfam match to entry PF01041.7 DegT_DnrJ_EryC1 216596004780 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 216596004781 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 216596004782 12 probable transmembrane helices predicted at aa 101-120, 130-147, 168-185,189-208, 229-251, 261-283, 316-338, 348-370, 377-396,406-428, 440-459 and 463-485 216596004783 Pfam match to entry PF01943.7 Polysacc_synt 216596004784 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 216596004785 SLBB domain; Region: SLBB; pfam10531 216596004786 Pfam match to entry PF02563.5 Poly_export 216596004787 1 probable transmembrane helix predicted at aa 7-29 216596004788 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 216596004789 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 216596004790 VCBS repeat; Region: VCBS_repeat; TIGR01965 216596004791 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 216596004792 Cadherin repeat-like domain; Region: CA_like; cl15786 216596004793 Ca2+ binding site [ion binding]; other site 216596004794 VCBS repeat; Region: VCBS_repeat; TIGR01965 216596004795 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 216596004796 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 216596004797 Pfam match to entry PF05345.1 He_PIG 216596004798 Predicted helix-turn-helix motif with score 1127.000, SD 3.03 at aa 1378-1399, sequence DTKTVTAIRFGVTAGTLGSALN 216596004799 Pfam match to entry PF05345.1 He_PIG 216596004800 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 216596004801 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 216596004802 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 216596004803 Pfam match to entry PF02492.7 cobW 216596004804 Pfam match to entry PF07683.1 CobW_C 216596004805 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 216596004806 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 216596004807 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 216596004808 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 216596004809 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 216596004810 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 216596004811 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 216596004812 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 216596004813 Pfam match to entry PF02492.7 cobW 216596004814 Pfam match to entry PF07683.1 CobW_C 216596004815 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 216596004816 putative active site [active] 216596004817 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 216596004818 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 216596004819 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216596004820 Walker A/P-loop; other site 216596004821 ATP binding site [chemical binding]; other site 216596004822 Q-loop/lid; other site 216596004823 ABC transporter signature motif; other site 216596004824 Walker B; other site 216596004825 D-loop; other site 216596004826 H-loop/switch region; other site 216596004827 Pfam match to entry PF03412.4 Peptidase_C39 216596004828 Pfam match to entry PF00664.10 ABC_membrane 216596004829 5 probable transmembrane helices predicted at aa 161-183, 193-215, 271-293,297-319 and 394-416 216596004830 Pfam match to entry PF00005.11 ABC_tran 216596004831 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 216596004832 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 216596004833 HlyD family secretion protein; Region: HlyD_3; pfam13437 216596004834 1 probable transmembrane helix predicted at aa 65-84 216596004835 Pfam match to entry PF00529.8 HlyD 216596004836 Predicted dehydrogenase [General function prediction only]; Region: COG0579 216596004837 hydroxyglutarate oxidase; Provisional; Region: PRK11728 216596004838 1 probable transmembrane helix predicted at aa 5-27 216596004839 Pfam match to entry PF01266.8 DAO 216596004840 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 216596004841 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 216596004842 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 216596004843 active site 216596004844 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 216596004845 Pfam match to entry PF01979.7 Amidohydro_1 216596004846 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596004847 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216596004848 putative substrate translocation pore; other site 216596004849 12 probable transmembrane helices predicted at aa 7-29, 44-66, 73-95, 99-121,134-156, 166-187, 217-239, 254-276, 283-305, 309-331,338-360 and 370-392 216596004850 Pfam match to entry PF07690.1 MFS_1 216596004851 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 216596004852 Helix-turn-helix domain; Region: HTH_38; pfam13936 216596004853 Homeodomain-like domain; Region: HTH_32; pfam13565 216596004854 Integrase core domain; Region: rve; pfam00665 216596004855 Pfam match to entry PF00665.10 rve 216596004856 Predicted helix-turn-helix motif with score 1253.000, SD 3.45 at aa 24-45, sequence ISVEMIAEKLHRHRSTIFRELR 216596004857 Winged helix-turn helix; Region: HTH_29; pfam13551 216596004858 Homeodomain-like domain; Region: HTH_32; pfam13565 216596004859 Integrase core domain; Region: rve; pfam00665 216596004860 Pfam match to entry PF00665.10 rve 216596004861 Predicted helix-turn-helix motif with score 1453.000, SD 4.14 at aa 27-48, sequence MTMVSAAHALDLSTRQVRRLLE 216596004862 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 216596004863 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 216596004864 Patatin phospholipase; Region: DUF3734; pfam12536 216596004865 Pfam match to entry PF01734.8 Patatin 216596004866 acetoacetate decarboxylase; Provisional; Region: PRK02265 216596004867 Pfam match to entry PF06314.1 ADC 216596004868 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 216596004869 classical (c) SDRs; Region: SDR_c; cd05233 216596004870 NAD(P) binding site [chemical binding]; other site 216596004871 active site 216596004872 Pfam match to entry PF00106.11 adh_short 216596004873 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 216596004874 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 216596004875 NAD binding site [chemical binding]; other site 216596004876 Pfam match to entry PF02826.5 2-Hacid_dh_C 216596004877 Similar C-terminus of Rhodopseudomonas palustris acetamidase/formamidase orfnames=rpa2415; SWALL:Q6N747 (EMBL:BX572600) (329 aa); similarity:fasta; SWALL:Q6N747 (EMBL:BX572600); Rhodopseudomonas palustris; acetamidase/formamidase; orfnames=rpa2415; length 329 aa; 101 aa overlap; query 10-110 aa; subject 229-329 aa; putative acetamidase/formamidase, pseudogene 216596004878 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 216596004879 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 216596004880 Pfam match to entry PF00561.8 Abhydrolase_1 216596004881 Autoinducer binding domain; Region: Autoind_bind; pfam03472 216596004882 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 216596004883 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216596004884 DNA binding residues [nucleotide binding] 216596004885 dimerization interface [polypeptide binding]; other site 216596004886 Pfam match to entry PF00196.8 GerE 216596004887 Pfam match to entry PF03472.4 Autoind_bind 216596004888 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 216596004889 Pfam match to entry PF00561.8 Abhydrolase_1 216596004890 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 216596004891 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596004892 dimer interface [polypeptide binding]; other site 216596004893 conserved gate region; other site 216596004894 putative PBP binding loops; other site 216596004895 ABC-ATPase subunit interface; other site 216596004896 5 probable transmembrane helices predicted at aa 12-34, 101-123, 136-158,241-263 and 284-306 216596004897 Pfam match to entry PF00528.10 BPD_transp_1 216596004898 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 216596004899 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596004900 dimer interface [polypeptide binding]; other site 216596004901 conserved gate region; other site 216596004902 putative PBP binding loops; other site 216596004903 ABC-ATPase subunit interface; other site 216596004904 6 probable transmembrane helices predicted at aa 21-43, 90-112, 119-141,146-165, 200-222 and 246-268 216596004905 Pfam match to entry PF00528.10 BPD_transp_1 216596004906 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 216596004907 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596004908 Walker A/P-loop; other site 216596004909 ATP binding site [chemical binding]; other site 216596004910 Q-loop/lid; other site 216596004911 ABC transporter signature motif; other site 216596004912 Walker B; other site 216596004913 D-loop; other site 216596004914 H-loop/switch region; other site 216596004915 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216596004916 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596004917 Walker A/P-loop; other site 216596004918 ATP binding site [chemical binding]; other site 216596004919 Q-loop/lid; other site 216596004920 ABC transporter signature motif; other site 216596004921 Walker B; other site 216596004922 D-loop; other site 216596004923 H-loop/switch region; other site 216596004924 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216596004925 Pfam match to entry PF00005.11 ABC_tran 216596004926 Pfam match to entry PF00005.11 ABC_tran 216596004927 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 216596004928 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 216596004929 Pfam match to entry PF00496.9 SBP_bac_5 216596004930 putative S-transferase; Provisional; Region: PRK11752 216596004931 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 216596004932 C-terminal domain interface [polypeptide binding]; other site 216596004933 GSH binding site (G-site) [chemical binding]; other site 216596004934 dimer interface [polypeptide binding]; other site 216596004935 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 216596004936 dimer interface [polypeptide binding]; other site 216596004937 N-terminal domain interface [polypeptide binding]; other site 216596004938 active site 216596004939 Pfam match to entry PF00043.11 GST_C 216596004940 Pfam match to entry PF02798.6 GST_N 216596004941 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 216596004942 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 216596004943 Walker A/P-loop; other site 216596004944 ATP binding site [chemical binding]; other site 216596004945 Q-loop/lid; other site 216596004946 ABC transporter signature motif; other site 216596004947 Walker B; other site 216596004948 D-loop; other site 216596004949 H-loop/switch region; other site 216596004950 TOBE domain; Region: TOBE_2; pfam08402 216596004951 Pfam match to entry PF03459.4 TOBE 216596004952 Pfam match to entry PF00005.11 ABC_tran 216596004953 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 216596004954 Pfam match to entry PF00190.9 Cupin 216596004955 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 216596004956 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 216596004957 Pfam match to entry PF01408.8 GFO_IDH_MocA 216596004958 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216596004959 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596004960 dimer interface [polypeptide binding]; other site 216596004961 conserved gate region; other site 216596004962 putative PBP binding loops; other site 216596004963 ABC-ATPase subunit interface; other site 216596004964 Pfam match to entry PF00528.10 BPD_transp_1 216596004965 6 probable transmembrane helices predicted at aa 12-31, 73-95, 107-129, 139-161,181-203 and 241-260 216596004966 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596004967 dimer interface [polypeptide binding]; other site 216596004968 conserved gate region; other site 216596004969 putative PBP binding loops; other site 216596004970 ABC-ATPase subunit interface; other site 216596004971 Pfam match to entry PF00528.10 BPD_transp_1 216596004972 6 probable transmembrane helices predicted at aa 55-77, 116-138, 145-167,198-220, 257-279 and 307-329 216596004973 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 216596004974 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 216596004975 Pfam match to entry PF01547.11 SBP_bac_1 216596004976 Transcriptional regulators [Transcription]; Region: GntR; COG1802 216596004977 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596004978 DNA-binding site [nucleotide binding]; DNA binding site 216596004979 FCD domain; Region: FCD; pfam07729 216596004980 Pfam match to entry PF00392.9 GntR 216596004981 hypothetical protein; Provisional; Region: PRK02399 216596004982 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 216596004983 Pfam match to entry PF06792.1 UPF0261 216596004984 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 216596004985 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 216596004986 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 216596004987 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 216596004988 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 216596004989 Ligand Binding Site [chemical binding]; other site 216596004990 Pfam match to entry PF00582.12 Usp 216596004991 chaperone protein DnaJ; Provisional; Region: PRK14299 216596004992 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 216596004993 HSP70 interaction site [polypeptide binding]; other site 216596004994 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 216596004995 substrate binding site [polypeptide binding]; other site 216596004996 dimer interface [polypeptide binding]; other site 216596004997 Pfam match to entry PF00226.14 DnaJ 216596004998 Pfam match to entry PF01556.7 DnaJ_C 216596004999 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 216596005000 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 216596005001 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 216596005002 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 216596005003 Pfam match to entry PF01148.9 CTP_transf_1 216596005004 7 probable transmembrane helices predicted at aa 4-26, 46-79, 94-111, 116-138,177-199, 219-238 and 243-265 216596005005 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 216596005006 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 216596005007 putative acyl-acceptor binding pocket; other site 216596005008 Pfam match to entry PF01553.9 Acyltransferase 216596005009 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 216596005010 Pfam match to entry PF01066.9 CDP-OH_P_transf 216596005011 3 probable transmembrane helices predicted at aa 67-89, 136-158 and 206-228 216596005012 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 216596005013 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 216596005014 putative ligand binding site [chemical binding]; other site 216596005015 Pfam match to entry PF02608.4 Bmp 216596005016 amidase; Provisional; Region: PRK07869 216596005017 Amidase; Region: Amidase; cl11426 216596005018 Pfam match to entry PF01425.8 Amidase 216596005019 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 216596005020 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 216596005021 Walker A/P-loop; other site 216596005022 ATP binding site [chemical binding]; other site 216596005023 Q-loop/lid; other site 216596005024 ABC transporter signature motif; other site 216596005025 Walker B; other site 216596005026 D-loop; other site 216596005027 H-loop/switch region; other site 216596005028 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 216596005029 Pfam match to entry PF00005.11 ABC_tran 216596005030 Pfam match to entry PF00005.11 ABC_tran 216596005031 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596005032 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 216596005033 TM-ABC transporter signature motif; other site 216596005034 6 probable transmembrane helices predicted at aa 13-35, 114-136, 149-168,192-214, 283-305 and 320-342 216596005035 Pfam match to entry PF02653.5 BPD_transp_2 216596005036 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596005037 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 216596005038 TM-ABC transporter signature motif; other site 216596005039 9 probable transmembrane helices predicted at aa 10-32, 37-59, 69-91, 98-115,125-147, 154-176, 202-224, 236-258 and 273-295 216596005040 Pfam match to entry PF02653.5 BPD_transp_2 216596005041 cytosine deaminase; Validated; Region: PRK07572 216596005042 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 216596005043 active site 216596005044 Pfam match to entry PF01979.7 Amidohydro_1 216596005045 hypothetical protein; Validated; Region: PRK08245 216596005046 Pfam match to entry PF03737.4 Methyltransf_6 216596005047 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 216596005048 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 216596005049 putative NAD(P) binding site [chemical binding]; other site 216596005050 putative active site [active] 216596005051 Pfam match to entry PF00106.11 adh_short 216596005052 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596005053 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596005054 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 216596005055 putative dimerization interface [polypeptide binding]; other site 216596005056 Pfam match to entry PF00126.10 HTH_1 216596005057 Predicted helix-turn-helix motif with score 1830.000, SD 5.42 at aa 16-37, sequence HSLAEAAQRLNLTPAAVAQRIR 216596005058 Pfam match to entry PF03466.5 LysR_substrate 216596005059 methionine sulfoxide reductase A; Provisional; Region: PRK14054 216596005060 Pfam match to entry PF01625.8 PMSR 216596005061 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 216596005062 hypothetical protein; Provisional; Region: PRK11622 216596005063 Pfam match to entry PF01547.11 SBP_bac_1 216596005064 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596005065 dimer interface [polypeptide binding]; other site 216596005066 conserved gate region; other site 216596005067 putative PBP binding loops; other site 216596005068 ABC-ATPase subunit interface; other site 216596005069 6 probable transmembrane helices predicted at aa 21-43, 82-104, 117-139,168-190, 220-242 and 266-288 216596005070 Pfam match to entry PF00528.10 BPD_transp_1 216596005071 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 216596005072 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596005073 dimer interface [polypeptide binding]; other site 216596005074 conserved gate region; other site 216596005075 putative PBP binding loops; other site 216596005076 ABC-ATPase subunit interface; other site 216596005077 6 probable transmembrane helices predicted at aa 12-34, 74-96, 108-130, 140-162,183-205 and 237-259 216596005078 Pfam match to entry PF00528.10 BPD_transp_1 216596005079 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 216596005080 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216596005081 Walker A/P-loop; other site 216596005082 ATP binding site [chemical binding]; other site 216596005083 Q-loop/lid; other site 216596005084 ABC transporter signature motif; other site 216596005085 Walker B; other site 216596005086 D-loop; other site 216596005087 H-loop/switch region; other site 216596005088 TOBE domain; Region: TOBE_2; pfam08402 216596005089 Pfam match to entry PF00005.11 ABC_tran 216596005090 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 216596005091 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 216596005092 active site 216596005093 dimerization interface [polypeptide binding]; other site 216596005094 Pfam match to entry PF00459.11 Inositol_P 216596005095 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 216596005096 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 216596005097 substrate binding site [chemical binding]; other site 216596005098 dimer interface [polypeptide binding]; other site 216596005099 ATP binding site [chemical binding]; other site 216596005100 Pfam match to entry PF00294.10 PfkB 216596005101 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 216596005102 Pfam match to entry PF03070.4 TENA_THI-4 216596005103 Predicted TIM-barrel enzyme [General function prediction only]; Region: SgcQ; COG0434 216596005104 Pfam match to entry PF03437.4 BtpA 216596005105 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 216596005106 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 216596005107 Pfam match to entry PF07090.1 DUF1355 216596005108 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 216596005109 active site 216596005110 substrate binding pocket [chemical binding]; other site 216596005111 homodimer interaction site [polypeptide binding]; other site 216596005112 Pfam match to entry PF02126.7 PTE 216596005113 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596005114 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216596005115 TM-ABC transporter signature motif; other site 216596005116 9 probable transmembrane helices predicted at aa 26-48, 60-82, 92-114, 127-149,169-191, 219-241, 251-269, 276-298 and 302-324 216596005117 Pfam match to entry PF02653.5 BPD_transp_2 216596005118 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 216596005119 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 216596005120 Walker A/P-loop; other site 216596005121 ATP binding site [chemical binding]; other site 216596005122 Q-loop/lid; other site 216596005123 ABC transporter signature motif; other site 216596005124 Walker B; other site 216596005125 D-loop; other site 216596005126 H-loop/switch region; other site 216596005127 Pfam match to entry PF00005.11 ABC_tran 216596005128 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 216596005129 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 216596005130 ligand binding site [chemical binding]; other site 216596005131 Pfam match to entry PF00532.8 Peripla_BP_1 216596005132 Transcriptional regulators [Transcription]; Region: PurR; COG1609 216596005133 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216596005134 DNA binding site [nucleotide binding] 216596005135 domain linker motif; other site 216596005136 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_11; cd06293 216596005137 putative dimerization interface [polypeptide binding]; other site 216596005138 putative ligand binding site [chemical binding]; other site 216596005139 Pfam match to entry PF00532.8 Peripla_BP_1 216596005140 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 216596005141 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596005142 dimer interface [polypeptide binding]; other site 216596005143 conserved gate region; other site 216596005144 putative PBP binding loops; other site 216596005145 ABC-ATPase subunit interface; other site 216596005146 Pfam match to entry PF00528.10 BPD_transp_1 216596005147 5 probable transmembrane helices predicted at aa 22-44, 93-115, 135-157, 201-223 and 255-277 216596005148 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 216596005149 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596005150 dimer interface [polypeptide binding]; other site 216596005151 conserved gate region; other site 216596005152 putative PBP binding loops; other site 216596005153 ABC-ATPase subunit interface; other site 216596005154 Pfam match to entry PF00528.10 BPD_transp_1 216596005155 6 probable transmembrane helices predicted at aa 7-29, 100-122, 135-157,172-191, 226-248 and 276-298 216596005156 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 216596005157 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596005158 Walker A/P-loop; other site 216596005159 ATP binding site [chemical binding]; other site 216596005160 Q-loop/lid; other site 216596005161 ABC transporter signature motif; other site 216596005162 Walker B; other site 216596005163 D-loop; other site 216596005164 H-loop/switch region; other site 216596005165 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 216596005166 Pfam match to entry PF00005.11 ABC_tran 216596005167 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 216596005168 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596005169 Walker A/P-loop; other site 216596005170 ATP binding site [chemical binding]; other site 216596005171 Q-loop/lid; other site 216596005172 ABC transporter signature motif; other site 216596005173 Walker B; other site 216596005174 D-loop; other site 216596005175 H-loop/switch region; other site 216596005176 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 216596005177 Pfam match to entry PF00005.11 ABC_tran 216596005178 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 216596005179 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515 216596005180 Pfam match to entry PF00496.9 SBP_bac_5 216596005181 Sulfatase; Region: Sulfatase; cl17466 216596005182 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 216596005183 Pfam match to entry PF00884.10 Sulfatase 216596005184 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 216596005185 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216596005186 Walker A/P-loop; other site 216596005187 ATP binding site [chemical binding]; other site 216596005188 Q-loop/lid; other site 216596005189 ABC transporter signature motif; other site 216596005190 Walker B; other site 216596005191 D-loop; other site 216596005192 H-loop/switch region; other site 216596005193 TOBE domain; Region: TOBE_2; pfam08402 216596005194 Pfam match to entry PF00005.11 ABC_tran 216596005195 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216596005196 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596005197 dimer interface [polypeptide binding]; other site 216596005198 conserved gate region; other site 216596005199 ABC-ATPase subunit interface; other site 216596005200 Pfam match to entry PF00528.10 BPD_transp_1 216596005201 6 probable transmembrane helices predicted at aa 9-31, 73-95, 104-126, 139-161,182-204 and 242-261 216596005202 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 216596005203 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596005204 dimer interface [polypeptide binding]; other site 216596005205 conserved gate region; other site 216596005206 putative PBP binding loops; other site 216596005207 ABC-ATPase subunit interface; other site 216596005208 Pfam match to entry PF00528.10 BPD_transp_1 216596005209 6 probable transmembrane helices predicted at aa 13-35, 80-102, 115-134,167-189, 210-232 and 269-291 216596005210 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 216596005211 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 216596005212 Pfam match to entry PF01547.11 SBP_bac_1 216596005213 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 216596005214 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 216596005215 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 216596005216 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 216596005217 Pfam match to entry PF02894.4 GFO_IDH_MocA_C 216596005218 Pfam match to entry PF01408.8 GFO_IDH_MocA 216596005219 Transcriptional regulators [Transcription]; Region: PurR; COG1609 216596005220 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216596005221 DNA binding site [nucleotide binding] 216596005222 domain linker motif; other site 216596005223 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 216596005224 ligand binding site [chemical binding]; other site 216596005225 Predicted helix-turn-helix motif with score 2074.000, SD 6.25 at aa 25-46, sequence KGIRQLAEHLNISIGTVSRALN 216596005226 Pfam match to entry PF00532.8 Peripla_BP_1 216596005227 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 216596005228 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 216596005229 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 216596005230 active site 216596005231 non-prolyl cis peptide bond; other site 216596005232 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 216596005233 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 216596005234 Flavin binding site [chemical binding]; other site 216596005235 Pfam match to entry PF02771.6 Acyl-CoA_dh_N 216596005236 Pfam match to entry PF00441.11 Acyl-CoA_dh 216596005237 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216596005238 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 216596005239 active site 216596005240 Pfam match to entry PF00441.11 Acyl-CoA_dh 216596005241 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 216596005242 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 216596005243 putative ligand binding site [chemical binding]; other site 216596005244 Pfam match to entry PF00532.8 Peripla_BP_1 216596005245 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 216596005246 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 216596005247 Walker A/P-loop; other site 216596005248 ATP binding site [chemical binding]; other site 216596005249 Q-loop/lid; other site 216596005250 ABC transporter signature motif; other site 216596005251 Walker B; other site 216596005252 D-loop; other site 216596005253 H-loop/switch region; other site 216596005254 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 216596005255 Pfam match to entry PF00005.11 ABC_tran 216596005256 Pfam match to entry PF00005.11 ABC_tran 216596005257 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216596005258 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596005259 TM-ABC transporter signature motif; other site 216596005260 9 probable transmembrane helices predicted at aa 31-53, 66-88, 93-112, 116-138,145-164, 195-217, 249-271, 281-298 and 303-325 216596005261 Pfam match to entry PF02653.5 BPD_transp_2 216596005262 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 216596005263 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 216596005264 active site 216596005265 non-prolyl cis peptide bond; other site 216596005266 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 216596005267 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 216596005268 Pfam match to entry PF00496.9 SBP_bac_5 216596005269 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 216596005270 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596005271 dimer interface [polypeptide binding]; other site 216596005272 conserved gate region; other site 216596005273 putative PBP binding loops; other site 216596005274 ABC-ATPase subunit interface; other site 216596005275 6 probable transmembrane helices predicted at aa 12-34, 103-125, 138-160,188-210, 246-268 and 292-311 216596005276 Pfam match to entry PF00528.10 BPD_transp_1 216596005277 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 216596005278 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596005279 dimer interface [polypeptide binding]; other site 216596005280 conserved gate region; other site 216596005281 putative PBP binding loops; other site 216596005282 ABC-ATPase subunit interface; other site 216596005283 5 probable transmembrane helices predicted at aa 13-35, 80-102, 123-145, 196-218 and 239-261 216596005284 Pfam match to entry PF00528.10 BPD_transp_1 216596005285 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 216596005286 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596005287 Walker A/P-loop; other site 216596005288 ATP binding site [chemical binding]; other site 216596005289 Q-loop/lid; other site 216596005290 ABC transporter signature motif; other site 216596005291 Walker B; other site 216596005292 D-loop; other site 216596005293 H-loop/switch region; other site 216596005294 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216596005295 Pfam match to entry PF00005.11 ABC_tran 216596005296 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596005297 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 216596005298 Walker A/P-loop; other site 216596005299 ATP binding site [chemical binding]; other site 216596005300 Q-loop/lid; other site 216596005301 ABC transporter signature motif; other site 216596005302 Walker B; other site 216596005303 D-loop; other site 216596005304 H-loop/switch region; other site 216596005305 Pfam match to entry PF00005.11 ABC_tran 216596005306 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 216596005307 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216596005308 catalytic residue [active] 216596005309 Pfam match to entry PF00266.8 Aminotran_5 216596005310 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 216596005311 Pfam match to entry PF01571.8 GCV_T 216596005312 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 216596005313 FAD binding site [chemical binding]; other site 216596005314 Transcriptional regulators [Transcription]; Region: GntR; COG1802 216596005315 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596005316 DNA-binding site [nucleotide binding]; DNA binding site 216596005317 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 216596005318 Pfam match to entry PF00392.9 GntR 216596005319 Predicted helix-turn-helix motif with score 1154.000, SD 3.12 at aa 42-63, sequence LSEVWLAEKLGISRTPLRAALA 216596005320 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 216596005321 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 216596005322 Pfam match to entry PF01094.13 ANF_receptor 216596005323 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 216596005324 TM-ABC transporter signature motif; other site 216596005325 8 probable transmembrane helices predicted at aa 4-26, 31-53, 58-80, 93-115,135-157, 178-200, 220-242 and 255-274 216596005326 Pfam match to entry PF02653.5 BPD_transp_2 216596005327 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 216596005328 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 216596005329 TM-ABC transporter signature motif; other site 216596005330 8 probable transmembrane helices predicted at aa 20-42, 62-84, 97-119, 144-166,175-194, 223-242, 262-284 and 294-313 216596005331 Pfam match to entry PF02653.5 BPD_transp_2 216596005332 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 216596005333 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 216596005334 Walker A/P-loop; other site 216596005335 ATP binding site [chemical binding]; other site 216596005336 Q-loop/lid; other site 216596005337 ABC transporter signature motif; other site 216596005338 Walker B; other site 216596005339 D-loop; other site 216596005340 H-loop/switch region; other site 216596005341 Pfam match to entry PF00005.11 ABC_tran 216596005342 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 216596005343 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 216596005344 Walker A/P-loop; other site 216596005345 ATP binding site [chemical binding]; other site 216596005346 Q-loop/lid; other site 216596005347 ABC transporter signature motif; other site 216596005348 Walker B; other site 216596005349 D-loop; other site 216596005350 H-loop/switch region; other site 216596005351 Pfam match to entry PF00005.11 ABC_tran 216596005352 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 216596005353 active site 216596005354 catalytic site [active] 216596005355 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 216596005356 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 216596005357 active site 216596005358 dimerization interface [polypeptide binding]; other site 216596005359 Pfam match to entry PF00459.11 Inositol_P 216596005360 Transcriptional regulators [Transcription]; Region: PurR; COG1609 216596005361 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216596005362 domain linker motif; other site 216596005363 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 216596005364 putative dimerization interface [polypeptide binding]; other site 216596005365 putative ligand binding site [chemical binding]; other site 216596005366 Pfam match to entry PF00532.8 Peripla_BP_1 216596005367 Predicted helix-turn-helix motif with score 1628.000, SD 4.73 at aa 11-32, sequence VTSFDVARVAGVSRAAVSRAFT 216596005368 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 216596005369 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 216596005370 active site 216596005371 catalytic site [active] 216596005372 metal binding site [ion binding]; metal-binding site 216596005373 Pfam match to entry PF03009.6 GDPD 216596005374 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 216596005375 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216596005376 Walker A/P-loop; other site 216596005377 ATP binding site [chemical binding]; other site 216596005378 Q-loop/lid; other site 216596005379 ABC transporter signature motif; other site 216596005380 Walker B; other site 216596005381 D-loop; other site 216596005382 H-loop/switch region; other site 216596005383 TOBE domain; Region: TOBE_2; pfam08402 216596005384 Pfam match to entry PF03459.4 TOBE 216596005385 Pfam match to entry PF00005.11 ABC_tran 216596005386 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216596005387 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596005388 dimer interface [polypeptide binding]; other site 216596005389 conserved gate region; other site 216596005390 putative PBP binding loops; other site 216596005391 ABC-ATPase subunit interface; other site 216596005392 Pfam match to entry PF00528.10 BPD_transp_1 216596005393 5 probable transmembrane helices predicted at aa 15-37, 79-101, 111-133, 140-162 and 247-269 216596005394 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 216596005395 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596005396 dimer interface [polypeptide binding]; other site 216596005397 conserved gate region; other site 216596005398 putative PBP binding loops; other site 216596005399 ABC-ATPase subunit interface; other site 216596005400 Pfam match to entry PF00528.10 BPD_transp_1 216596005401 6 probable transmembrane helices predicted at aa 7-29, 201-223, 244-266,286-308, 342-364 and 395-417 216596005402 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 216596005403 Pfam match to entry PF01547.11 SBP_bac_1 216596005404 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 216596005405 putative deacylase active site [active] 216596005406 Pfam match to entry PF04073.3 YbaK 216596005407 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 216596005408 2 probable transmembrane helices predicted at aa 90-112 and 116-138 216596005409 Pfam match to entry PF04280.4 Tim44 216596005410 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 216596005411 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167 216596005412 putative ligand binding site [chemical binding]; other site 216596005413 putative NAD binding site [chemical binding]; other site 216596005414 catalytic site [active] 216596005415 Pfam match to entry PF02826.5 2-Hacid_dh_C 216596005416 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 216596005417 7 probable transmembrane helices predicted at aa 7-26, 36-58, 65-87, 91-110,115-132, 147-169 and 178-200 216596005418 Pfam match to entry PF04955.2 HupE_UreJ 216596005419 Predicted transcriptional regulators [Transcription]; Region: COG1510 216596005420 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216596005421 dimerization interface [polypeptide binding]; other site 216596005422 putative DNA binding site [nucleotide binding]; other site 216596005423 putative Zn2+ binding site [ion binding]; other site 216596005424 Predicted helix-turn-helix motif with score 1599.000, SD 4.63 at aa 73-94, sequence ICAEEIAESLGISRSNVSMSLR 216596005425 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 216596005426 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 216596005427 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 216596005428 Walker A/P-loop; other site 216596005429 ATP binding site [chemical binding]; other site 216596005430 Q-loop/lid; other site 216596005431 ABC transporter signature motif; other site 216596005432 Walker B; other site 216596005433 D-loop; other site 216596005434 H-loop/switch region; other site 216596005435 Pfam match to entry PF00664.10 ABC_membrane 216596005436 2 probable transmembrane helices predicted at aa 134-156 and 217-239 216596005437 Pfam match to entry PF00005.11 ABC_tran 216596005438 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 216596005439 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216596005440 Walker A/P-loop; other site 216596005441 ATP binding site [chemical binding]; other site 216596005442 Q-loop/lid; other site 216596005443 ABC transporter signature motif; other site 216596005444 Walker B; other site 216596005445 D-loop; other site 216596005446 H-loop/switch region; other site 216596005447 6 probable transmembrane helices predicted at aa 34-56, 66-88, 152-174, 179-201,266-288 and 293-315 216596005448 Pfam match to entry PF00005.11 ABC_tran 216596005449 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 216596005450 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 216596005451 Pfam match to entry PF01654.6 Bac_Ubq_Cox 216596005452 9 probable transmembrane helices predicted at aa 20-42, 55-77, 97-119, 126-148,187-209, 222-239, 392-414, 426-448 and 471-493 216596005453 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 216596005454 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 216596005455 Pfam match to entry PF02322.5 Cyto_ox_2 216596005456 9 probable transmembrane helices predicted at aa 15-37, 58-80, 90-109, 130-152,172-194, 207-229, 264-286, 298-320 and 340-362 216596005457 Predicted transcriptional regulator [Transcription]; Region: COG3905 216596005458 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 216596005459 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 216596005460 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 216596005461 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 216596005462 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 216596005463 active site 216596005464 catalytic tetrad [active] 216596005465 Pfam match to entry PF00248.9 Aldo_ket_red 216596005466 Pfam match to entry PF02894.4 GFO_IDH_MocA_C 216596005467 Pfam match to entry PF01408.8 GFO_IDH_MocA 216596005468 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 216596005469 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 216596005470 Walker A/P-loop; other site 216596005471 ATP binding site [chemical binding]; other site 216596005472 Q-loop/lid; other site 216596005473 ABC transporter signature motif; other site 216596005474 Walker B; other site 216596005475 D-loop; other site 216596005476 H-loop/switch region; other site 216596005477 Pfam match to entry PF03459.4 TOBE 216596005478 Pfam match to entry PF00005.11 ABC_tran 216596005479 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216596005480 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596005481 dimer interface [polypeptide binding]; other site 216596005482 conserved gate region; other site 216596005483 putative PBP binding loops; other site 216596005484 ABC-ATPase subunit interface; other site 216596005485 Pfam match to entry PF00528.10 BPD_transp_1 216596005486 6 probable transmembrane helices predicted at aa 13-35, 70-92, 105-127, 142-164,185-207 and 242-264 216596005487 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 216596005488 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596005489 dimer interface [polypeptide binding]; other site 216596005490 conserved gate region; other site 216596005491 putative PBP binding loops; other site 216596005492 ABC-ATPase subunit interface; other site 216596005493 Pfam match to entry PF00528.10 BPD_transp_1 216596005494 6 probable transmembrane helices predicted at aa 7-29, 67-89, 102-124, 153-175,196-218 and 259-281 216596005495 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 216596005496 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 216596005497 Pfam match to entry PF01547.11 SBP_bac_1 216596005498 Cupin domain; Region: Cupin_2; pfam07883 216596005499 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 216596005500 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216596005501 Pfam match to entry PF00165.8 HTH_AraC 216596005502 Pfam match to entry PF00165.8 HTH_AraC 216596005503 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 216596005504 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 216596005505 Pfam match to entry PF03180.3 Lipoprotein_9 216596005506 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 216596005507 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 216596005508 dimer interface [polypeptide binding]; other site 216596005509 conserved gate region; other site 216596005510 putative PBP binding loops; other site 216596005511 ABC-ATPase subunit interface; other site 216596005512 4 probable transmembrane helices predicted at aa 12-34, 79-101, 113-135 and 236-255 216596005513 Pfam match to entry PF00528.10 BPD_transp_1 216596005514 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 216596005515 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 216596005516 Walker A/P-loop; other site 216596005517 ATP binding site [chemical binding]; other site 216596005518 Q-loop/lid; other site 216596005519 ABC transporter signature motif; other site 216596005520 Walker B; other site 216596005521 D-loop; other site 216596005522 H-loop/switch region; other site 216596005523 Pfam match to entry PF00005.11 ABC_tran 216596005524 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 216596005525 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 216596005526 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 216596005527 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 216596005528 urea carboxylase; Region: urea_carbox; TIGR02712 216596005529 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 216596005530 ATP-grasp domain; Region: ATP-grasp_4; cl17255 216596005531 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 216596005532 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 216596005533 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 216596005534 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 216596005535 carboxyltransferase (CT) interaction site; other site 216596005536 biotinylation site [posttranslational modification]; other site 216596005537 Pfam match to entry PF00289.9 CPSase_L_chain 216596005538 Pfam match to entry PF02786.4 CPSase_L_D2 216596005539 Pfam match to entry PF02785.5 Biotin_carb_C 216596005540 Pfam match to entry PF02626.5 AHS2 216596005541 Pfam match to entry PF02682.5 AHS1 216596005542 Pfam match to entry PF00364.9 Biotin_lipoyl 216596005543 allophanate hydrolase; Provisional; Region: PRK08186 216596005544 Amidase; Region: Amidase; cl11426 216596005545 Pfam match to entry PF01425.8 Amidase 216596005546 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 216596005547 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216596005548 active site 216596005549 Pfam match to entry PF00903.11 Glyoxalase 216596005550 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 216596005551 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 216596005552 Pfam match to entry PF02894.4 GFO_IDH_MocA_C 216596005553 Pfam match to entry PF01408.8 GFO_IDH_MocA 216596005554 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 216596005555 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 216596005556 Pfam match to entry PF01408.8 GFO_IDH_MocA 216596005557 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 216596005558 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 216596005559 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 216596005560 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 216596005561 active site 216596005562 substrate binding site [chemical binding]; other site 216596005563 coenzyme B12 binding site [chemical binding]; other site 216596005564 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 216596005565 B12 binding site [chemical binding]; other site 216596005566 cobalt ligand [ion binding]; other site 216596005567 Pfam match to entry PF02310.8 B12-binding 216596005568 Pfam match to entry PF01642.9 MM_CoA_mutase 216596005569 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 216596005570 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 216596005571 active site 216596005572 non-prolyl cis peptide bond; other site 216596005573 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596005574 dimer interface [polypeptide binding]; other site 216596005575 conserved gate region; other site 216596005576 ABC-ATPase subunit interface; other site 216596005577 Pfam match to entry PF00528.10 BPD_transp_1 216596005578 5 probable transmembrane helices predicted at aa 20-42, 62-84, 88-110, 148-170 and 190-209 216596005579 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 216596005580 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 216596005581 Walker A/P-loop; other site 216596005582 ATP binding site [chemical binding]; other site 216596005583 Q-loop/lid; other site 216596005584 ABC transporter signature motif; other site 216596005585 Walker B; other site 216596005586 D-loop; other site 216596005587 H-loop/switch region; other site 216596005588 NIL domain; Region: NIL; pfam09383 216596005589 Pfam match to entry PF00005.11 ABC_tran 216596005590 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 216596005591 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 216596005592 Pfam match to entry PF03180.3 Lipoprotein_9 216596005593 1 probable transmembrane helix predicted at aa 17-39 216596005594 FMN reductase, MsuE subfamily; Region: FMN_reduc_MsuE; TIGR03566 216596005595 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 216596005596 Pfam match to entry PF03358.3 FMN_red 216596005597 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596005598 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216596005599 putative substrate translocation pore; other site 216596005600 10 probable transmembrane helices predicted at aa 21-43, 53-75, 96-118, 173-195,216-238, 258-280, 287-306, 310-332, 341-363 and 373-395 216596005601 Pfam match to entry PF07690.1 MFS_1 216596005602 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 216596005603 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216596005604 non-specific DNA binding site [nucleotide binding]; other site 216596005605 salt bridge; other site 216596005606 sequence-specific DNA binding site [nucleotide binding]; other site 216596005607 Pfam match to entry PF01381.9 HTH_3 216596005608 Predicted helix-turn-helix motif with score 1941.000, SD 5.80 at aa 26-47, sequence MSQERLAEQIGVTFQQVQKYEK 216596005609 Codons 80 to the C-terminus are similar to codons 350 to the C-terminus of Rhizobium meliloti putative L-arabinose isomerase protein name=smb21420; SWALL:Q92U88 (EMBL:AL603646) (475 aa); similarity:fasta; SWALL:Q92U88 (EMBL:AL603646); Rhizobium meliloti; putative L-arabinose isomerase protein; name=smb21420; length 475 aa; 124 aa overlap; query 81-204 aa; subject 352-475 aa; putative L-arabinose isomerase, pseudogene 216596005610 Predicted secreted hydrolase [General function prediction only]; Region: COG5621 216596005611 FtsX-like permease family; Region: FtsX; pfam02687 216596005612 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 216596005613 Pfam match to entry PF02687.7 FtsX 216596005614 10 probable transmembrane helices predicted at aa 20-42, 226-248, 276-298,325-347, 368-390, 395-417, 444-466, 666-688, 720-742 and 762-781 216596005615 Pfam match to entry PF02687.7 FtsX 216596005616 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 216596005617 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 216596005618 Walker A/P-loop; other site 216596005619 ATP binding site [chemical binding]; other site 216596005620 Q-loop/lid; other site 216596005621 ABC transporter signature motif; other site 216596005622 Walker B; other site 216596005623 D-loop; other site 216596005624 H-loop/switch region; other site 216596005625 Pfam match to entry PF00005.11 ABC_tran 216596005626 similarity:fasta; SWALL:Q8KJB2 (EMBL:AL672114); Rhizobium loti; putative transposase for insertion sequence; msi258; length 345 aa; 30 aa overlap; query 1-30 aa; subject 1-30 aa; putative transposase, pseudogene 216596005627 TspO/MBR family; Region: TspO_MBR; pfam03073 216596005628 Pfam match to entry PF03073.5 TspO_MBR 216596005629 4 probable transmembrane helices predicted at aa 10-27, 48-70, 98-120 and 127-149 216596005630 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 216596005631 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216596005632 DNA binding site [nucleotide binding] 216596005633 Predicted ATPase [General function prediction only]; Region: COG3903 216596005634 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 216596005635 binding surface 216596005636 TPR motif; other site 216596005637 Pfam match to entry PF06492.1 DUF1095 216596005638 Pfam match to entry PF06498.1 Ad_Cycl_assoc 216596005639 Pfam match to entry PF00486.12 Trans_reg_C 216596005640 Epoxide hydrolase N terminus; Region: EHN; pfam06441 216596005641 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 216596005642 Pfam match to entry PF06441.1 EHN 216596005643 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 216596005644 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216596005645 Pfam match to entry PF00903.11 Glyoxalase 216596005646 OsmC-like protein; Region: OsmC; cl00767 216596005647 Pfam match to entry PF02566.5 OsmC 216596005648 Protein of unknown function (DUF972); Region: DUF972; pfam06156 216596005649 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 216596005650 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 216596005651 DNA-binding site [nucleotide binding]; DNA binding site 216596005652 RNA-binding motif; other site 216596005653 Pfam match to entry PF00313.8 CSD 216596005654 similarity:fasta; SWALL:Q6N2T8 (EMBL:BX572605); Rhodopseudomonas palustris; hypothetical protein; orfnames=rpa3960; length 267 aa; 155 aa overlap; query 31-179 aa; subject 85-231 aa; conserved hypothetical protein, pseudogene 216596005655 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 216596005656 substrate binding site [chemical binding]; other site 216596005657 active site 216596005658 PEP synthetase regulatory protein; Provisional; Region: PRK05339 216596005659 Pfam match to entry PF03618.4 DUF299 216596005660 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 216596005661 active site 216596005662 dimer interface [polypeptide binding]; other site 216596005663 Pfam match to entry PF02545.4 Maf 216596005664 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 216596005665 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 216596005666 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 216596005667 shikimate binding site; other site 216596005668 NAD(P) binding site [chemical binding]; other site 216596005669 Pfam match to entry PF01488.5 Shikimate_DH 216596005670 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 216596005671 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 216596005672 CoA-binding site [chemical binding]; other site 216596005673 ATP-binding [chemical binding]; other site 216596005674 Pfam match to entry PF01121.8 CoaE 216596005675 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 216596005676 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 216596005677 active site 216596005678 catalytic site [active] 216596005679 substrate binding site [chemical binding]; other site 216596005680 Pfam match to entry PF00929.11 Exonuc_X-T 216596005681 preprotein translocase subunit SecB; Validated; Region: PRK05751 216596005682 SecA binding site; other site 216596005683 Preprotein binding site; other site 216596005684 Pfam match to entry PF02556.4 SecB 216596005685 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 216596005686 Pfam match to entry PF04186.2 FxsA 216596005687 3 probable transmembrane helices predicted at aa 7-26, 30-52 and 83-105 216596005688 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 216596005689 Pfam match to entry PF04280.4 Tim44 216596005690 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 216596005691 MltA specific insert domain; Region: MltA; smart00925 216596005692 3D domain; Region: 3D; pfam06725 216596005693 Pfam match to entry PF03562.4 MltA 216596005694 Pfam match to entry PF06725.1 3D 216596005695 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 216596005696 Smr domain; Region: Smr; pfam01713 216596005697 Pfam match to entry PF01713.8 Smr 216596005698 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 216596005699 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216596005700 non-specific DNA binding site [nucleotide binding]; other site 216596005701 salt bridge; other site 216596005702 sequence-specific DNA binding site [nucleotide binding]; other site 216596005703 Pfam match to entry PF01381.9 HTH_3 216596005704 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 216596005705 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596005706 Mg2+ binding site [ion binding]; other site 216596005707 G-X-G motif; other site 216596005708 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 216596005709 anchoring element; other site 216596005710 dimer interface [polypeptide binding]; other site 216596005711 ATP binding site [chemical binding]; other site 216596005712 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 216596005713 active site 216596005714 putative metal-binding site [ion binding]; other site 216596005715 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 216596005716 Pfam match to entry PF02518.9 HATPase_c 216596005717 Pfam match to entry PF00204.9 DNA_gyraseB 216596005718 Pfam match to entry PF01751.7 Toprim 216596005719 Pfam match to entry PF00986.8 DNA_gyraseB_C 216596005720 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 216596005721 putative FMN binding site [chemical binding]; other site 216596005722 Pfam match to entry PF00881.10 Nitroreductase 216596005723 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981 216596005724 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 216596005725 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 216596005726 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 216596005727 putative dimer interface [polypeptide binding]; other site 216596005728 N-terminal domain interface [polypeptide binding]; other site 216596005729 putative substrate binding pocket (H-site) [chemical binding]; other site 216596005730 Pfam match to entry PF00043.11 GST_C 216596005731 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 216596005732 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 216596005733 Pfam match to entry PF01557.8 FAA_hydrolase 216596005734 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 216596005735 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 216596005736 Pfam match to entry PF06850.1 PHB_depo_C 216596005737 Protein of unknown function (DUF2852); Region: DUF2852; pfam11014 216596005738 1 probable transmembrane helix predicted at aa 15-37 216596005739 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 216596005740 Pfam match to entry PF01863.6 DUF45 216596005741 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 216596005742 active site 216596005743 Pfam match to entry PF00697.10 PRAI 216596005744 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 216596005745 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 216596005746 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596005747 catalytic residue [active] 216596005748 Pfam match to entry PF00291.10 PALP 216596005749 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 216596005750 substrate binding site [chemical binding]; other site 216596005751 active site 216596005752 catalytic residues [active] 216596005753 heterodimer interface [polypeptide binding]; other site 216596005754 Pfam match to entry PF00290.9 Trp_syntA 216596005755 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 216596005756 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 216596005757 Pfam match to entry PF01039.9 Carboxyl_trans 216596005758 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 216596005759 Pfam match to entry PF01225.11 Mur_ligase 216596005760 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 216596005761 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 216596005762 catalytic residues [active] 216596005763 Pfam match to entry PF00085.8 Thioredoxin 216596005764 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 216596005765 Part of AAA domain; Region: AAA_19; pfam13245 216596005766 Family description; Region: UvrD_C_2; pfam13538 216596005767 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 216596005768 Pfam match to entry PF00580.8 UvrD-helicase 216596005769 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 216596005770 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 216596005771 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 216596005772 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 216596005773 Substrate binding site; other site 216596005774 metal-binding site 216596005775 Pfam match to entry PF00483.9 NTP_transferase 216596005776 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 216596005777 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 216596005778 Phosphotransferase enzyme family; Region: APH; pfam01636 216596005779 Pfam match to entry PF02367.5 UPF0079 216596005780 PAS fold; Region: PAS_7; pfam12860 216596005781 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 216596005782 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216596005783 dimer interface [polypeptide binding]; other site 216596005784 phosphorylation site [posttranslational modification] 216596005785 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596005786 ATP binding site [chemical binding]; other site 216596005787 Mg2+ binding site [ion binding]; other site 216596005788 G-X-G motif; other site 216596005789 Pfam match to entry PF02518.9 HATPase_c 216596005790 Pfam match to entry PF00512.10 HisKA 216596005791 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 216596005792 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 216596005793 homotetramer interface [polypeptide binding]; other site 216596005794 ligand binding site [chemical binding]; other site 216596005795 catalytic site [active] 216596005796 NAD binding site [chemical binding]; other site 216596005797 Pfam match to entry PF05221.5 AdoHcyase 216596005798 Pfam match to entry PF00670.10 AdoHcyase_NAD 216596005799 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 216596005800 dimerization domain swap beta strand [polypeptide binding]; other site 216596005801 regulatory protein interface [polypeptide binding]; other site 216596005802 active site 216596005803 regulatory phosphorylation site [posttranslational modification]; other site 216596005804 Pfam match to entry PF00381.8 PTS-HPr 216596005805 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 216596005806 active pocket/dimerization site; other site 216596005807 active site 216596005808 phosphorylation site [posttranslational modification] 216596005809 Pfam match to entry PF03610.4 EIIA-man 216596005810 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 216596005811 Hpr binding site; other site 216596005812 active site 216596005813 homohexamer subunit interaction site [polypeptide binding]; other site 216596005814 Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755 216596005815 Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756 216596005816 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 216596005817 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 216596005818 dimerization interface [polypeptide binding]; other site 216596005819 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216596005820 dimer interface [polypeptide binding]; other site 216596005821 phosphorylation site [posttranslational modification] 216596005822 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596005823 ATP binding site [chemical binding]; other site 216596005824 Mg2+ binding site [ion binding]; other site 216596005825 G-X-G motif; other site 216596005826 Pfam match to entry PF02518.9 HATPase_c 216596005827 Pfam match to entry PF00512.10 HisKA 216596005828 Pfam match to entry PF00672.10 HAMP 216596005829 1 probable transmembrane helix predicted at aa 49-68 216596005830 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 216596005831 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596005832 active site 216596005833 phosphorylation site [posttranslational modification] 216596005834 intermolecular recognition site; other site 216596005835 dimerization interface [polypeptide binding]; other site 216596005836 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216596005837 DNA binding site [nucleotide binding] 216596005838 Pfam match to entry PF00486.11 Trans_reg_C 216596005839 Pfam match to entry PF00072.9 Response_reg 216596005840 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 216596005841 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 216596005842 active site 216596005843 substrate-binding site [chemical binding]; other site 216596005844 metal-binding site [ion binding] 216596005845 ATP binding site [chemical binding]; other site 216596005846 Pfam match to entry PF01293.8 PEPCK_ATP 216596005847 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 216596005848 hypothetical protein; Provisional; Region: PRK09256 216596005849 Pfam match to entry PF00472.8 RF-1 216596005850 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 216596005851 Pfam match to entry PF03171.7 2OG-FeII_Oxy 216596005852 pantothenate kinase; Provisional; Region: PRK05439 216596005853 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 216596005854 ATP-binding site [chemical binding]; other site 216596005855 CoA-binding site [chemical binding]; other site 216596005856 Mg2+-binding site [ion binding]; other site 216596005857 Pfam match to entry PF00485.7 PRK 216596005858 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 216596005859 metal binding site [ion binding]; metal-binding site 216596005860 Pfam match to entry PF01503.6 PRA-PH 216596005861 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 216596005862 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 216596005863 substrate binding site [chemical binding]; other site 216596005864 glutamase interaction surface [polypeptide binding]; other site 216596005865 Pfam match to entry PF00977.8 His_biosynth 216596005866 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 216596005867 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 216596005868 catalytic residues [active] 216596005869 Pfam match to entry PF00977.8 His_biosynth 216596005870 1 probable transmembrane helix predicted at aa 144-166 216596005871 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 216596005872 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 216596005873 putative active site [active] 216596005874 oxyanion strand; other site 216596005875 catalytic triad [active] 216596005876 Pfam match to entry PF00117.10 GATase 216596005877 2 probable transmembrane helices predicted at aa 27-46 and 66-85 216596005878 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 216596005879 putative active site pocket [active] 216596005880 4-fold oligomerization interface [polypeptide binding]; other site 216596005881 metal binding residues [ion binding]; metal-binding site 216596005882 3-fold/trimer interface [polypeptide binding]; other site 216596005883 Pfam match to entry PF00475.7 IGPD 216596005884 ATP-dependent protease subunit HslV; Provisional; Region: PRK05456 216596005885 active site 216596005886 Pfam match to entry PF00227.11 Proteasome 216596005887 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 216596005888 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 216596005889 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 216596005890 Pfam match to entry PF00583.9 Acetyltransf_1 216596005891 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 216596005892 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216596005893 Walker A motif; other site 216596005894 ATP binding site [chemical binding]; other site 216596005895 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 216596005896 Walker B motif; other site 216596005897 arginine finger; other site 216596005898 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 216596005899 Pfam match to entry PF00004.12 AAA 216596005900 Protein of unknown function (DUF1402); Region: DUF1402; pfam07182 216596005901 Pfam match to entry PF07182.1 DUF1402 216596005902 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 216596005903 Cytochrome P450; Region: p450; cl12078 216596005904 Pfam match to entry PF00067.9 p450 216596005905 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 216596005906 active site 216596005907 Pfam match to entry PF01274.10 Malate_synthase 216596005908 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 216596005909 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 216596005910 Pfam match to entry PF03734.4 ErfK_YbiS_YhnG 216596005911 Protein of unknown function (DUF1052); Region: DUF1052; pfam06319 216596005912 Pfam match to entry PF06319.1 DUF1052 216596005913 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 216596005914 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596005915 active site 216596005916 phosphorylation site [posttranslational modification] 216596005917 intermolecular recognition site; other site 216596005918 dimerization interface [polypeptide binding]; other site 216596005919 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 216596005920 Pfam match to entry PF00072.9 Response_reg 216596005921 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 216596005922 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216596005923 dimer interface [polypeptide binding]; other site 216596005924 phosphorylation site [posttranslational modification] 216596005925 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596005926 ATP binding site [chemical binding]; other site 216596005927 Mg2+ binding site [ion binding]; other site 216596005928 G-X-G motif; other site 216596005929 Pfam match to entry PF02518.9 HATPase_c 216596005930 Pfam match to entry PF00512.10 HisKA 216596005931 4 probable transmembrane helices predicted at aa 51-73, 124-146, 158-180 and 190-212 216596005932 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 216596005933 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 216596005934 ATP binding site [chemical binding]; other site 216596005935 putative Mg++ binding site [ion binding]; other site 216596005936 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216596005937 nucleotide binding region [chemical binding]; other site 216596005938 ATP-binding site [chemical binding]; other site 216596005939 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 216596005940 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 216596005941 Pfam match to entry PF04408.6 HA2 216596005942 Pfam match to entry PF00271.13 Helicase_C 216596005943 Pfam match to entry PF00270.12 DEAD 216596005944 ornithine cyclodeaminase; Validated; Region: PRK06141 216596005945 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 216596005946 Pfam match to entry PF02423.5 OCD_Mu_crystall 216596005947 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_1; cd11347 216596005948 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 216596005949 active site 216596005950 catalytic site [active] 216596005951 Pfam match to entry PF00128.11 Alpha-amylase 216596005952 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 216596005953 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 216596005954 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 216596005955 ligand binding site [chemical binding]; other site 216596005956 Predicted periplasmic protein (DUF2092); Region: DUF2092; cl17607 216596005957 Pfam match to entry PF00691.7 OmpA 216596005958 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 216596005959 Putative glucoamylase; Region: Glycoamylase; pfam10091 216596005960 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 216596005961 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 216596005962 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 216596005963 Protein of unknown function, DUF608; Region: DUF608; pfam04685 216596005964 Pfam match to entry PF06205.1 GT36_AF 216596005965 Pfam match to entry PF06165.1 Glyco_transf_36 216596005966 Pfam match to entry PF06204.1 CBM_X 216596005967 Pfam match to entry PF06205.1 GT36_AF 216596005968 Pfam match to entry PF06165.1 Glyco_transf_36 216596005969 Pfam match to entry PF06204.1 CBM_X 216596005970 putative phosphoketolase; Provisional; Region: PRK05261 216596005971 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 216596005972 TPP-binding site; other site 216596005973 XFP C-terminal domain; Region: XFP_C; pfam09363 216596005974 Pfam match to entry PF03894.3 XFP 216596005975 FOG: CBS domain [General function prediction only]; Region: COG0517 216596005976 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 216596005977 BON domain; Region: BON; pfam04972 216596005978 Pfam match to entry PF04972.3 BON 216596005979 Pfam match to entry PF00571.13 CBS 216596005980 Pfam match to entry PF00571.13 CBS 216596005981 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 216596005982 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 216596005983 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 216596005984 6 probable transmembrane helices predicted at aa 33-55, 76-95, 143-165, 172-194,261-283 and 290-312 216596005985 Pfam match to entry PF00664.9 ABC_membrane 216596005986 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 216596005987 Tetratricopeptide repeat; Region: TPR_16; pfam13432 216596005988 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216596005989 binding surface 216596005990 Tetratricopeptide repeat; Region: TPR_16; pfam13432 216596005991 TPR motif; other site 216596005992 Tetratricopeptide repeat; Region: TPR_16; pfam13432 216596005993 Pfam match to entry PF00515.11 TPR 216596005994 Pfam match to entry PF00515.11 TPR8 216596005995 Pfam match to entry PF00515.11 TPR8 216596005996 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 216596005997 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 216596005998 HlyD family secretion protein; Region: HlyD_3; pfam13437 216596005999 Pfam match to entry PF00529.8 HlyD 216596006000 1 probable transmembrane helix predicted at aa 26-48 216596006001 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 216596006002 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 216596006003 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 216596006004 Walker A/P-loop; other site 216596006005 ATP binding site [chemical binding]; other site 216596006006 Q-loop/lid; other site 216596006007 ABC transporter signature motif; other site 216596006008 Walker B; other site 216596006009 D-loop; other site 216596006010 H-loop/switch region; other site 216596006011 Pfam match to entry PF00005.11 ABC_tran 216596006012 Pfam match to entry PF00664.9 ABC_membrane 216596006013 5 probable transmembrane helices predicted at aa 214-236, 251-268, 316-338,343-365 and 447-469 216596006014 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 216596006015 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216596006016 DNA binding residues [nucleotide binding] 216596006017 dimerization interface [polypeptide binding]; other site 216596006018 Pfam match to entry PF00196.8 GerE 216596006019 1 probable transmembrane helix predicted at aa 15-37 216596006020 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 216596006021 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 216596006022 NAD binding site [chemical binding]; other site 216596006023 putative substrate binding site 2 [chemical binding]; other site 216596006024 putative substrate binding site 1 [chemical binding]; other site 216596006025 active site 216596006026 Pfam match to entry PF01370.8 Epimerase 216596006027 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 216596006028 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 216596006029 NAD binding site [chemical binding]; other site 216596006030 homodimer interface [polypeptide binding]; other site 216596006031 active site 216596006032 substrate binding site [chemical binding]; other site 216596006033 Pfam match to entry PF01370.8 Epimerase 216596006034 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 216596006035 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 216596006036 active site 216596006037 8 probable transmembrane helices predicted at aa 32-51, 64-86, 363-385, 398-420,435-457, 477-499, 509-531 and 544-566 216596006038 Pfam match to entry PF00535.10 Glycos_transf_2 216596006039 Protein of unknown function (DUF995); Region: DUF995; pfam06191 216596006040 Pfam match to entry PF06191.1 DUF995 216596006041 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 216596006042 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 216596006043 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 216596006044 Pfam match to entry PF01547.11 SBP_bac_1 216596006045 1 probable transmembrane helix predicted at aa 7-29 216596006046 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216596006047 DNA binding site [nucleotide binding] 216596006048 Transcriptional regulators [Transcription]; Region: PurR; COG1609 216596006049 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 216596006050 ligand binding site [chemical binding]; other site 216596006051 dimerization interface [polypeptide binding]; other site 216596006052 Pfam match to entry PF00356.8 LacI 216596006053 Pfam match to entry PF00532.8 Peripla_BP_1 216596006054 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4289 216596006055 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 216596006056 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167 216596006057 putative ligand binding site [chemical binding]; other site 216596006058 putative NAD binding site [chemical binding]; other site 216596006059 catalytic site [active] 216596006060 Pfam match to entry PF02826.5 2-Hacid_dh_C 216596006061 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 216596006062 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 216596006063 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 216596006064 Pfam match to entry PF02894.4 GFO_IDH_MocA_C 216596006065 Pfam match to entry PF01408.8 GFO_IDH_MocA 216596006066 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 216596006067 Protein of unknown function (DUF993); Region: DUF993; pfam06187 216596006068 Pfam match to entry PF06187.1 DUF993 216596006069 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 216596006070 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 216596006071 Pfam match to entry PF02894.4 GFO_IDH_MocA_C 216596006072 Pfam match to entry PF01408.8 GFO_IDH_MocA 216596006073 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 216596006074 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216596006075 Pfam match to entry PF00440.8 TetR_N 216596006076 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 216596006077 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 216596006078 Pfam match to entry PF01547.11 SBP_bac_1 216596006079 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596006080 dimer interface [polypeptide binding]; other site 216596006081 conserved gate region; other site 216596006082 putative PBP binding loops; other site 216596006083 ABC-ATPase subunit interface; other site 216596006084 7 probable transmembrane helices predicted at aa 37-59, 96-118, 131-153, 181-203,224-246, 256-275 and 288-310 216596006085 Pfam match to entry PF00528.10 BPD_transp_1 216596006086 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216596006087 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596006088 dimer interface [polypeptide binding]; other site 216596006089 conserved gate region; other site 216596006090 putative PBP binding loops; other site 216596006091 ABC-ATPase subunit interface; other site 216596006092 6 probable transmembrane helices predicted at aa 21-43, 88-110, 122-144, 154-176,197-219 and 260-282 216596006093 Pfam match to entry PF00528.10 BPD_transp_1 216596006094 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 216596006095 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 216596006096 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 216596006097 Pfam match to entry PF01408.8 GFO_IDH_MocA 216596006098 Pfam match to entry PF02894.4 GFO_IDH_MocA_C 216596006099 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 216596006100 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 216596006101 Walker A/P-loop; other site 216596006102 ATP binding site [chemical binding]; other site 216596006103 Q-loop/lid; other site 216596006104 ABC transporter signature motif; other site 216596006105 Walker B; other site 216596006106 D-loop; other site 216596006107 H-loop/switch region; other site 216596006108 TOBE domain; Region: TOBE_2; pfam08402 216596006109 Pfam match to entry PF00005.11 ABC_tran 216596006110 Pfam match to entry PF03459.4 TOBE 216596006111 Phosphotransferase enzyme family; Region: APH; pfam01636 216596006112 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 216596006113 active site 216596006114 substrate binding site [chemical binding]; other site 216596006115 ATP binding site [chemical binding]; other site 216596006116 dimer interface [polypeptide binding]; other site 216596006117 Pfam match to entry PF01633.7 Choline_kinase 216596006118 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 216596006119 hydroxyglutarate oxidase; Provisional; Region: PRK11728 216596006120 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 216596006121 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 216596006122 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 216596006123 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 216596006124 Pfam match to entry PF01266.8 DAO 216596006125 Pfam match to entry PF01571.8 GCV_T 216596006126 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 216596006127 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 216596006128 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 216596006129 Pfam match to entry PF01232.10 Mannitol_dh 216596006130 glucuronate isomerase; Reviewed; Region: PRK02925 216596006131 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 216596006132 Pfam match to entry PF02614.4 UxaC 216596006133 hypothetical protein; Provisional; Region: PRK00736 216596006134 Pfam match to entry PF04102.2 SlyX 216596006135 succinic semialdehyde dehydrogenase; Region: PLN02278 216596006136 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 216596006137 tetramerization interface [polypeptide binding]; other site 216596006138 NAD(P) binding site [chemical binding]; other site 216596006139 catalytic residues [active] 216596006140 Pfam match to entry PF00171.9 Aldedh 216596006141 4-aminobutyrate aminotransferase; Provisional; Region: PRK07495 216596006142 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 216596006143 inhibitor-cofactor binding pocket; inhibition site 216596006144 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596006145 catalytic residue [active] 216596006146 Pfam match to entry PF00202.8 Aminotran_3 216596006147 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 216596006148 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 216596006149 DNA binding residues [nucleotide binding] 216596006150 dimer interface [polypeptide binding]; other site 216596006151 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 216596006152 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216596006153 non-specific DNA binding site [nucleotide binding]; other site 216596006154 salt bridge; other site 216596006155 sequence-specific DNA binding site [nucleotide binding]; other site 216596006156 Cupin domain; Region: Cupin_2; pfam07883 216596006157 Pfam match to entry PF00376.9 MerR 216596006158 Pfam match to entry PF01381.9 HTH_3 216596006159 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 216596006160 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 216596006161 catalytic site [active] 216596006162 putative active site [active] 216596006163 putative substrate binding site [chemical binding]; other site 216596006164 Pfam match to entry PF01612.10 3_5_exonuc 216596006165 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 216596006166 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 216596006167 RNA binding site [nucleotide binding]; other site 216596006168 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 216596006169 RNA binding site [nucleotide binding]; other site 216596006170 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 216596006171 RNA binding site [nucleotide binding]; other site 216596006172 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 216596006173 RNA binding site [nucleotide binding]; other site 216596006174 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 216596006175 RNA binding site [nucleotide binding]; other site 216596006176 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 216596006177 RNA binding site [nucleotide binding]; other site 216596006178 Pfam match to entry PF00575.9 S1 216596006179 Pfam match to entry PF00575.9 S1 216596006180 Pfam match to entry PF00575.9 S1 216596006181 Pfam match to entry PF00575.9 S1 216596006182 Pfam match to entry PF00575.9 S1 216596006183 Pfam match to entry PF00575.9 S1 216596006184 cytidylate kinase; Provisional; Region: cmk; PRK00023 216596006185 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 216596006186 CMP-binding site; other site 216596006187 The sites determining sugar specificity; other site 216596006188 Pfam match to entry PF02224.5 Cytidylate_kin 216596006189 Pfam match to entry PF00406.10 ADK 216596006190 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 216596006191 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 216596006192 hinge; other site 216596006193 active site 216596006194 Pfam match to entry PF00275.8 EPSP_synthase 216596006195 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4530 216596006196 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 216596006197 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 216596006198 GIY-YIG motif/motif A; other site 216596006199 putative active site [active] 216596006200 putative metal binding site [ion binding]; other site 216596006201 Pfam match to entry PF01541.11 GIY-YIG 216596006202 Predicted membrane protein [Function unknown]; Region: COG3619 216596006203 6 probable transmembrane helices predicted at aa 31-53, 81-103, 110-129, 149-171,191-208 and 212-234 216596006204 Pfam match to entry PF06912.1 DUF1275 216596006205 Uncharacterized conserved protein [Function unknown]; Region: COG1434 216596006206 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 216596006207 putative active site [active] 216596006208 2 probable transmembrane helices predicted at aa 10-31 and 38-60 216596006209 Pfam match to entry PF02698.5 DUF218 216596006210 Predicted membrane protein [Function unknown]; Region: COG2860 216596006211 UPF0126 domain; Region: UPF0126; pfam03458 216596006212 UPF0126 domain; Region: UPF0126; pfam03458 216596006213 7 probable transmembrane helices predicted at aa 4-23, 30-52, 56-78, 90-107,111-133, 145-167 and 172-194 216596006214 Pfam match to entry PF03458.3 UPF0126 216596006215 Pfam match to entry PF03458.3 UPF0126 216596006216 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 216596006217 metal binding site 2 [ion binding]; metal-binding site 216596006218 putative DNA binding helix; other site 216596006219 metal binding site 1 [ion binding]; metal-binding site 216596006220 dimer interface [polypeptide binding]; other site 216596006221 Pfam match to entry PF01475.6 FUR 216596006222 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 216596006223 active site 1 [active] 216596006224 dimer interface [polypeptide binding]; other site 216596006225 active site 2 [active] 216596006226 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 216596006227 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 216596006228 dimer interface [polypeptide binding]; other site 216596006229 active site 216596006230 Pfam match to entry PF00109.11 ketoacyl-synt 216596006231 Pfam match to entry PF02801.7 Ketoacyl-synt_C 216596006232 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505 216596006233 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 216596006234 NAD binding site [chemical binding]; other site 216596006235 homotetramer interface [polypeptide binding]; other site 216596006236 homodimer interface [polypeptide binding]; other site 216596006237 substrate binding site [chemical binding]; other site 216596006238 active site 216596006239 Pfam match to entry PF00106.11 adh_short 216596006240 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 216596006241 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596006242 S-adenosylmethionine binding site [chemical binding]; other site 216596006243 Pfam match to entry PF05175.2 MTS 216596006244 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 216596006245 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 216596006246 RNase E interface [polypeptide binding]; other site 216596006247 trimer interface [polypeptide binding]; other site 216596006248 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 216596006249 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 216596006250 RNase E interface [polypeptide binding]; other site 216596006251 trimer interface [polypeptide binding]; other site 216596006252 active site 216596006253 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 216596006254 putative nucleic acid binding region [nucleotide binding]; other site 216596006255 G-X-X-G motif; other site 216596006256 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 216596006257 RNA binding site [nucleotide binding]; other site 216596006258 domain interface; other site 216596006259 Pfam match to entry PF00575.9 S1 216596006260 Pfam match to entry PF00013.12 KH_1 216596006261 Pfam match to entry PF03725.4 RNase_PH_C 216596006262 Pfam match to entry PF01138.10 RNase_PH 216596006263 Pfam match to entry PF03726.3 PNPase 216596006264 Pfam match to entry PF03725.4 RNase_PH_C 216596006265 Pfam match to entry PF01138.10 RNase_PH 216596006266 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 216596006267 16S/18S rRNA binding site [nucleotide binding]; other site 216596006268 S13e-L30e interaction site [polypeptide binding]; other site 216596006269 25S rRNA binding site [nucleotide binding]; other site 216596006270 Pfam match to entry PF00312.9 Ribosomal_S15 216596006271 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216596006272 Pfam match to entry PF00561.8 Abhydrolase_1 216596006273 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 216596006274 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 216596006275 RNA binding site [nucleotide binding]; other site 216596006276 active site 216596006277 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 216596006278 Pfam match to entry PF01509.7 TruB_N 216596006279 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 216596006280 Pfam match to entry PF02033.5 RBFA 216596006281 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 216596006282 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 216596006283 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 216596006284 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 216596006285 G1 box; other site 216596006286 putative GEF interaction site [polypeptide binding]; other site 216596006287 GTP/Mg2+ binding site [chemical binding]; other site 216596006288 Switch I region; other site 216596006289 G2 box; other site 216596006290 G3 box; other site 216596006291 Switch II region; other site 216596006292 G4 box; other site 216596006293 G5 box; other site 216596006294 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 216596006295 Translation-initiation factor 2; Region: IF-2; pfam11987 216596006296 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 216596006297 Pfam match to entry PF03144.8 GTP_EFTU_D2 216596006298 Pfam match to entry PF03144.8 GTP_EFTU_D2 216596006299 Pfam match to entry PF00009.10 GTP_EFTU 216596006300 Pfam match to entry PF04760.3 IF2_N 216596006301 hypothetical protein; Provisional; Region: PRK09190 216596006302 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 216596006303 putative RNA binding cleft [nucleotide binding]; other site 216596006304 Pfam match to entry PF04296.2 DUF448 216596006305 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 216596006306 NusA N-terminal domain; Region: NusA_N; pfam08529 216596006307 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 216596006308 RNA binding site [nucleotide binding]; other site 216596006309 homodimer interface [polypeptide binding]; other site 216596006310 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 216596006311 G-X-X-G motif; other site 216596006312 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 216596006313 G-X-X-G motif; other site 216596006314 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 216596006315 Pfam match to entry PF00013.12 KH_1 216596006316 Pfam match to entry PF00575.9 S1 216596006317 ribosome maturation protein RimP; Reviewed; Region: PRK00092 216596006318 Sm and related proteins; Region: Sm_like; cl00259 216596006319 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 216596006320 putative oligomer interface [polypeptide binding]; other site 216596006321 putative RNA binding site [nucleotide binding]; other site 216596006322 Pfam match to entry PF02576.5 DUF150 216596006323 Transmembrane secretion effector; Region: MFS_3; pfam05977 216596006324 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596006325 putative substrate translocation pore; other site 216596006326 Pfam match to entry PF05977.1 DUF894 216596006327 10 probable transmembrane helices predicted at aa 35-57, 67-89, 110-132, 181-203,244-266, 271-293, 306-328, 333-352, 365-387 and 391-413 216596006328 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 216596006329 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216596006330 Coenzyme A binding pocket [chemical binding]; other site 216596006331 Pfam match to entry PF00583.9 Acetyltransf_1 216596006332 Transglycosylase SLT domain; Region: SLT_2; pfam13406 216596006333 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 216596006334 N-acetyl-D-glucosamine binding site [chemical binding]; other site 216596006335 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 216596006336 1 probable transmembrane helix predicted at aa 13-35 216596006337 recombination protein RecR; Reviewed; Region: recR; PRK00076 216596006338 RecR protein; Region: RecR; pfam02132 216596006339 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 216596006340 putative active site [active] 216596006341 putative metal-binding site [ion binding]; other site 216596006342 tetramer interface [polypeptide binding]; other site 216596006343 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 216596006344 MOSC domain; Region: MOSC; pfam03473 216596006345 Pfam match to entry PF03473.5 MOSC 216596006346 hypothetical protein; Validated; Region: PRK00153 216596006347 Pfam match to entry PF02575.4 DUF149 216596006348 DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111 216596006349 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216596006350 Walker A motif; other site 216596006351 ATP binding site [chemical binding]; other site 216596006352 Walker B motif; other site 216596006353 arginine finger; other site 216596006354 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 216596006355 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 216596006356 Pfam match to entry PF00004.12 AAA 216596006357 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 216596006358 nucleotide binding site/active site [active] 216596006359 HIT family signature motif; other site 216596006360 catalytic residue [active] 216596006361 Pfam match to entry PF01230.10 HIT 216596006362 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 216596006363 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 216596006364 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 216596006365 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 216596006366 putative NADH binding site [chemical binding]; other site 216596006367 putative active site [active] 216596006368 nudix motif; other site 216596006369 putative metal binding site [ion binding]; other site 216596006370 Pfam match to entry PF00293.12 NUDIX 216596006371 HTH domain; Region: HTH_11; pfam08279 216596006372 Predicted transcriptional regulator [Transcription]; Region: COG2378 216596006373 WYL domain; Region: WYL; pfam13280 216596006374 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 216596006375 putative dimer interface [polypeptide binding]; other site 216596006376 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216596006377 Pfam match to entry PF00903.11 Glyoxalase 216596006378 prephenate dehydratase; Provisional; Region: PRK11899 216596006379 Prephenate dehydratase; Region: PDT; pfam00800 216596006380 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 216596006381 putative L-Phe binding site [chemical binding]; other site 216596006382 Pfam match to entry PF01842.8 ACT 216596006383 Pfam match to entry PF00800.8 PDT 216596006384 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 216596006385 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 216596006386 Ligand binding site; other site 216596006387 oligomer interface; other site 216596006388 Pfam match to entry PF02348.6 CTP_transf_3 216596006389 Cytochrome c2 [Energy production and conversion]; Region: COG3474 216596006390 1 probable transmembrane helix predicted at aa 7-29 216596006391 Pfam match to entry PF00034.8 Cytochrom_C 216596006392 Predicted permeases [General function prediction only]; Region: COG0679 216596006393 9 probable transmembrane helices predicted at aa 21-43, 88-110, 117-136, 146-168,189-211, 221-243, 250-272, 282-304 and 311-333 216596006394 Pfam match to entry PF03547.6 Auxin_eff 216596006395 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 216596006396 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 216596006397 substrate binding site [chemical binding]; other site 216596006398 ATP binding site [chemical binding]; other site 216596006399 Pfam match to entry PF00294.10 PfkB 216596006400 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807 216596006401 Bacterial SH3 domain; Region: SH3_4; pfam06347 216596006402 Bacterial SH3 domain; Region: SH3_4; pfam06347 216596006403 Pfam match to entry PF06347.1 DUF1058 216596006404 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 216596006405 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 216596006406 dimerization interface [polypeptide binding]; other site 216596006407 ligand binding site [chemical binding]; other site 216596006408 NADP binding site [chemical binding]; other site 216596006409 catalytic site [active] 216596006410 Pfam match to entry PF00389.14 2-Hacid_dh 216596006411 Pfam match to entry PF02826.5 2-Hacid_dh_C 216596006412 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 216596006413 Pfam match to entry PF00583.9 Acetyltransf_1 216596006414 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 216596006415 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 216596006416 ATP binding site [chemical binding]; other site 216596006417 substrate interface [chemical binding]; other site 216596006418 Pfam match to entry PF05237.1 MoeZ_MoeB 216596006419 Pfam match to entry PF00899.8 ThiF 216596006420 recombination protein F; Reviewed; Region: recF; PRK00064 216596006421 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 216596006422 Walker A/P-loop; other site 216596006423 ATP binding site [chemical binding]; other site 216596006424 Q-loop/lid; other site 216596006425 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216596006426 ABC transporter signature motif; other site 216596006427 Walker B; other site 216596006428 D-loop; other site 216596006429 H-loop/switch region; other site 216596006430 Pfam match to entry PF02463.6 SMC_N 216596006431 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 216596006432 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216596006433 non-specific DNA binding site [nucleotide binding]; other site 216596006434 salt bridge; other site 216596006435 sequence-specific DNA binding site [nucleotide binding]; other site 216596006436 Pfam match to entry PF01381.9 HTH_3 216596006437 chaperone protein DnaJ; Provisional; Region: PRK10767 216596006438 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 216596006439 HSP70 interaction site [polypeptide binding]; other site 216596006440 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 216596006441 substrate binding site [polypeptide binding]; other site 216596006442 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 216596006443 Zn binding sites [ion binding]; other site 216596006444 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 216596006445 dimer interface [polypeptide binding]; other site 216596006446 Pfam match to entry PF01556.7 DnaJ_C 216596006447 Pfam match to entry PF00684.8 DnaJ_CXXCXGXG 216596006448 Pfam match to entry PF00226.13 DnaJ 216596006449 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 216596006450 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 216596006451 nucleotide binding site [chemical binding]; other site 216596006452 NEF interaction site [polypeptide binding]; other site 216596006453 SBD interface [polypeptide binding]; other site 216596006454 Pfam match to entry PF00012.7 HSP70 216596006455 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 216596006456 Transglycosylase; Region: Transgly; pfam00912 216596006457 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 216596006458 Pfam match to entry PF00905.8 Transpeptidase 216596006459 Pfam match to entry PF00912.8 Transgly 216596006460 1 probable transmembrane helix predicted at aa 82-104 216596006461 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 216596006462 Bacterial SH3 domain; Region: SH3_3; pfam08239 216596006463 hypothetical protein; Validated; Region: PRK09104 216596006464 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 216596006465 metal binding site [ion binding]; metal-binding site 216596006466 putative dimer interface [polypeptide binding]; other site 216596006467 Pfam match to entry PF01546.12 Peptidase_M20 216596006468 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 216596006469 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 216596006470 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 216596006471 PAS fold; Region: PAS_4; pfam08448 216596006472 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 216596006473 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216596006474 metal binding site [ion binding]; metal-binding site 216596006475 active site 216596006476 I-site; other site 216596006477 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216596006478 7 probable transmembrane helices predicted at aa 15-35, 48-70, 80-102, 115-134,144-166, 178-200 and 215-237 216596006479 Pfam match to entry PF03707.5 MHYT 216596006480 Pfam match to entry PF03707.5 MHYT 216596006481 Pfam match to entry PF00990.8 GGDEF 216596006482 Pfam match to entry PF00563.9 EAL 216596006483 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 216596006484 MarR family; Region: MarR_2; pfam12802 216596006485 Pfam match to entry PF01047.8 MarR 216596006486 DNA polymerase I; Region: pola; TIGR00593 216596006487 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 216596006488 active site 216596006489 metal binding site 1 [ion binding]; metal-binding site 216596006490 putative 5' ssDNA interaction site; other site 216596006491 metal binding site 3; metal-binding site 216596006492 metal binding site 2 [ion binding]; metal-binding site 216596006493 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 216596006494 putative DNA binding site [nucleotide binding]; other site 216596006495 putative metal binding site [ion binding]; other site 216596006496 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 216596006497 active site 216596006498 catalytic site [active] 216596006499 substrate binding site [chemical binding]; other site 216596006500 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 216596006501 active site 216596006502 DNA binding site [nucleotide binding] 216596006503 catalytic site [active] 216596006504 Pfam match to entry PF02739.5 5_3_exonuc_N 216596006505 Pfam match to entry PF01367.9 5_3_exonuc 216596006506 Pfam match to entry PF01612.10 3_5_exonuc 216596006507 Pfam match to entry PF00476.9 DNA_pol_A 216596006508 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 216596006509 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 216596006510 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 216596006511 Pfam match to entry PF01580.8 FtsK_SpoIIIE 216596006512 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 216596006513 Pfam match to entry PF04229.3 UPF0157 216596006514 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 216596006515 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 216596006516 active site 216596006517 Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454 216596006518 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 216596006519 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 216596006520 active site 216596006521 Pfam match to entry PF01979.7 Amidohydro_1 216596006522 putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223 216596006523 Pfam match to entry PF06299.1 DUF1045 216596006524 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 216596006525 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596006526 dimer interface [polypeptide binding]; other site 216596006527 conserved gate region; other site 216596006528 ABC-ATPase subunit interface; other site 216596006529 Pfam match to entry PF00528.10 BPD_transp_1 216596006530 4 probable transmembrane helices predicted at aa 32-54, 257-279, 306-328 and 419-441 216596006531 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 216596006532 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596006533 dimer interface [polypeptide binding]; other site 216596006534 conserved gate region; other site 216596006535 ABC-ATPase subunit interface; other site 216596006536 Pfam match to entry PF00528.10 BPD_transp_1 216596006537 6 probable transmembrane helices predicted at aa 33-55, 114-136, 140-162, 175-197,256-278 and 290-309 216596006538 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 216596006539 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 216596006540 Transposase; Region: DEDD_Tnp_IS110; pfam01548 216596006541 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 216596006542 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 216596006543 Pfam match to entry PF02371.5 Transposase_20 216596006544 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 216596006545 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 216596006546 Walker A/P-loop; other site 216596006547 ATP binding site [chemical binding]; other site 216596006548 Q-loop/lid; other site 216596006549 ABC transporter signature motif; other site 216596006550 Walker B; other site 216596006551 D-loop; other site 216596006552 H-loop/switch region; other site 216596006553 Pfam match to entry PF00005.11 ABC_tran 216596006554 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 216596006555 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 216596006556 trimer interface [polypeptide binding]; other site 216596006557 active site 216596006558 substrate binding site [chemical binding]; other site 216596006559 CoA binding site [chemical binding]; other site 216596006560 Pfam match to entry PF00132.9 Hexapep1 216596006561 Pfam match to entry PF00132.9 Hexapep 216596006562 Pfam match to entry PF00132.9 Hexapep 216596006563 Pfam match to entry PF00132.9 Hexapep 216596006564 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 216596006565 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216596006566 Walker A/P-loop; other site 216596006567 ATP binding site [chemical binding]; other site 216596006568 Q-loop/lid; other site 216596006569 ABC transporter signature motif; other site 216596006570 Walker B; other site 216596006571 D-loop; other site 216596006572 H-loop/switch region; other site 216596006573 Pfam match to entry PF00005.11 ABC_tran 216596006574 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 216596006575 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596006576 Walker A/P-loop; other site 216596006577 ATP binding site [chemical binding]; other site 216596006578 Q-loop/lid; other site 216596006579 ABC transporter signature motif; other site 216596006580 Walker B; other site 216596006581 D-loop; other site 216596006582 H-loop/switch region; other site 216596006583 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216596006584 Pfam match to entry PF00005.11 ABC_tran 216596006585 Phosphonate metabolism protein PhnJ; Region: PhnJ; cl01457 216596006586 Pfam match to entry PF06007.1 PhnJ 216596006587 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626 216596006588 Pfam match to entry PF05861.1 PhnI 216596006589 carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147 216596006590 Pfam match to entry PF05845.1 PhnH 216596006591 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 216596006592 Pfam match to entry PF06754.1 PhnG 216596006593 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 216596006594 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596006595 DNA-binding site [nucleotide binding]; DNA binding site 216596006596 UTRA domain; Region: UTRA; pfam07702 216596006597 Pfam match to entry PF00392.9 GntR 216596006598 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 216596006599 catalytic core [active] 216596006600 Pfam match to entry PF00300.9 PGAM 216596006601 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 216596006602 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 216596006603 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 216596006604 Pfam match to entry PF05173.2 DapB_C 216596006605 Pfam match to entry PF01113.9 DapB_N 216596006606 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 216596006607 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 216596006608 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 216596006609 Walker A/P-loop; other site 216596006610 ATP binding site [chemical binding]; other site 216596006611 Q-loop/lid; other site 216596006612 ABC transporter signature motif; other site 216596006613 Walker B; other site 216596006614 D-loop; other site 216596006615 H-loop/switch region; other site 216596006616 Pfam match to entry PF00005.11 ABC_tran 216596006617 Pfam match to entry PF00664.9 ABC_membrane 216596006618 5 probable transmembrane helices predicted at aa 32-54, 69-91, 112-134, 168-190 and 283-302 216596006619 glucokinase; Provisional; Region: glk; PRK00292 216596006620 glucokinase, proteobacterial type; Region: glk; TIGR00749 216596006621 Pfam match to entry PF02685.4 Glucokinase 216596006622 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 216596006623 active site 216596006624 dimer interfaces [polypeptide binding]; other site 216596006625 catalytic residues [active] 216596006626 Pfam match to entry PF02142.8 MGS 216596006627 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 216596006628 Pfam match to entry PF03411.3 Peptidase_U6 216596006629 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 216596006630 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 216596006631 Pfam match to entry PF00496.8 SBP_bac_5 216596006632 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 216596006633 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596006634 dimer interface [polypeptide binding]; other site 216596006635 conserved gate region; other site 216596006636 putative PBP binding loops; other site 216596006637 ABC-ATPase subunit interface; other site 216596006638 6 probable transmembrane helices predicted at aa 9-31, 129-151, 168-190, 221-243,279-301 and 325-347 216596006639 Pfam match to entry PF00528.10 BPD_transp_1 216596006640 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 216596006641 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596006642 dimer interface [polypeptide binding]; other site 216596006643 conserved gate region; other site 216596006644 putative PBP binding loops; other site 216596006645 ABC-ATPase subunit interface; other site 216596006646 5 probable transmembrane helices predicted at aa 38-60, 182-204, 228-262, 293-315 and 346-368 216596006647 Pfam match to entry PF00528.10 BPD_transp_1 216596006648 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 216596006649 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596006650 Walker A/P-loop; other site 216596006651 ATP binding site [chemical binding]; other site 216596006652 Q-loop/lid; other site 216596006653 ABC transporter signature motif; other site 216596006654 Walker B; other site 216596006655 D-loop; other site 216596006656 H-loop/switch region; other site 216596006657 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 216596006658 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596006659 Walker A/P-loop; other site 216596006660 ATP binding site [chemical binding]; other site 216596006661 Q-loop/lid; other site 216596006662 ABC transporter signature motif; other site 216596006663 Walker B; other site 216596006664 D-loop; other site 216596006665 H-loop/switch region; other site 216596006666 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216596006667 Pfam match to entry PF00005.11 ABC_tran 216596006668 Pfam match to entry PF00005.11 ABC_tran 216596006669 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 216596006670 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 216596006671 putative ligand binding site [chemical binding]; other site 216596006672 NAD binding site [chemical binding]; other site 216596006673 dimerization interface [polypeptide binding]; other site 216596006674 catalytic site [active] 216596006675 Pfam match to entry PF02826.5 2-Hacid_dh_C 216596006676 1 probable transmembrane helix predicted at aa 37-59 216596006677 Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488 216596006678 nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321 216596006679 active site 216596006680 Pfam match to entry PF04095.4 NAPRTase 216596006681 KTSC domain; Region: KTSC; pfam13619 216596006682 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 216596006683 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216596006684 Pfam match to entry PF06821.1 DUF1234 216596006685 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 216596006686 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216596006687 putative DNA binding site [nucleotide binding]; other site 216596006688 putative Zn2+ binding site [ion binding]; other site 216596006689 AsnC family; Region: AsnC_trans_reg; pfam01037 216596006690 Pfam match to entry PF01037.8 AsnC_trans_reg 216596006691 2 probable transmembrane helices predicted at aa 7-29 and 72-94 216596006692 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 216596006693 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 216596006694 ligand binding site [chemical binding]; other site 216596006695 Pfam match to entry PF02608.4 Bmp 216596006696 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 216596006697 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 216596006698 Walker A/P-loop; other site 216596006699 ATP binding site [chemical binding]; other site 216596006700 Q-loop/lid; other site 216596006701 ABC transporter signature motif; other site 216596006702 Walker B; other site 216596006703 D-loop; other site 216596006704 H-loop/switch region; other site 216596006705 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 216596006706 Pfam match to entry PF00005.11 ABC_tran 216596006707 Pfam match to entry PF00005.11 ABC_tran 216596006708 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596006709 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 216596006710 TM-ABC transporter signature motif; other site 216596006711 9 probable transmembrane helices predicted at aa 15-37, 57-79, 115-137, 150-172,203-225, 248-270, 280-299, 306-325 and 335-353 216596006712 Pfam match to entry PF02653.5 BPD_transp_2 216596006713 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596006714 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 216596006715 TM-ABC transporter signature motif; other site 216596006716 7 probable transmembrane helices predicted at aa 7-29, 63-85, 92-114, 159-176,208-230, 245-267 and 287-309 216596006717 Pfam match to entry PF02653.5 BPD_transp_2 216596006718 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 216596006719 active site 216596006720 catalytic motif [active] 216596006721 Zn binding site [ion binding]; other site 216596006722 Pfam match to entry PF00383.9 dCMP_cyt_deam 216596006723 purine nucleoside phosphorylase; Provisional; Region: PRK08202 216596006724 Pfam match to entry PF00896.9 Mtap_PNP 216596006725 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 216596006726 intersubunit interface [polypeptide binding]; other site 216596006727 active site 216596006728 catalytic residue [active] 216596006729 Pfam match to entry PF01791.6 DeoC 216596006730 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 216596006731 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 216596006732 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 216596006733 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 216596006734 Pfam match to entry PF02885.5 Glycos_trans_3N 216596006735 Pfam match to entry PF00591.9 Glycos_transf_3 216596006736 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 216596006737 catalytic motif [active] 216596006738 Catalytic residue [active] 216596006739 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 216596006740 active site 216596006741 Pfam match to entry PF00156.11 Pribosyltran 216596006742 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 216596006743 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 216596006744 active site 216596006745 purine riboside binding site [chemical binding]; other site 216596006746 Pfam match to entry PF00962.10 A_deaminase 216596006747 phosphopentomutase; Provisional; Region: PRK05362 216596006748 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 216596006749 Pfam match to entry PF01676.6 Metalloenzyme 216596006750 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 216596006751 TadE-like protein; Region: TadE; pfam07811 216596006752 1 probable transmembrane helix predicted at aa 24-46 216596006753 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 216596006754 TadE-like protein; Region: TadE; pfam07811 216596006755 1 probable transmembrane helix predicted at aa 37-59 216596006756 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 216596006757 1 probable transmembrane helix predicted at aa 33-52 216596006758 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 216596006759 Pfam match to entry PF04964.3 Flp_Fap 216596006760 1 probable transmembrane helix predicted at aa 20-39 216596006761 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 216596006762 5 probable transmembrane helices predicted at aa 5-27, 31-50, 57-76, 96-118 and 144-166 216596006763 Pfam match to entry PF01478.6 Peptidase_A24 216596006764 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 216596006765 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 216596006766 1 probable transmembrane helix predicted at aa 7-29 216596006767 Pfam match to entry PF06981.1 CpaB 216596006768 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 216596006769 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 216596006770 BON domain; Region: BON; pfam04972 216596006771 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 216596006772 1 probable transmembrane helix predicted at aa 13-35 216596006773 Pfam match to entry PF04972.3 BON 216596006774 Pfam match to entry PF00263.9 Secretin_C 216596006775 Type IV pili component [Cell motility and secretion]; Region: COG5461 216596006776 Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476 216596006777 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 216596006778 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 216596006779 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 216596006780 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 216596006781 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 216596006782 ATP binding site [chemical binding]; other site 216596006783 Walker A motif; other site 216596006784 hexamer interface [polypeptide binding]; other site 216596006785 Walker B motif; other site 216596006786 Pfam match to entry PF00437.9 GSPII_E 216596006787 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 216596006788 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 216596006789 5 probable transmembrane helices predicted at aa 6-28, 108-127, 131-153, 276-295 and 310-332 216596006790 Pfam match to entry PF00482.9 GSPII_F 216596006791 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 216596006792 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 216596006793 4 probable transmembrane helices predicted at aa 15-37, 118-140, 150-172 and 300-322 216596006794 Pfam match to entry PF00482.9 GSPII_F 216596006795 LysE type translocator; Region: LysE; cl00565 216596006796 5 probable transmembrane helices predicted at aa 5-27, 40-62, 72-91, 111-133 and 148-170 216596006797 Pfam match to entry PF01810.7 LysE 216596006798 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 216596006799 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216596006800 TPR motif; other site 216596006801 binding surface 216596006802 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 216596006803 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 216596006804 interface (dimer of trimers) [polypeptide binding]; other site 216596006805 Substrate-binding/catalytic site; other site 216596006806 Zn-binding sites [ion binding]; other site 216596006807 Pfam match to entry PF00883.9 Peptidase_M17 216596006808 Transcriptional regulators [Transcription]; Region: MarR; COG1846 216596006809 MarR family; Region: MarR_2; cl17246 216596006810 Pfam match to entry PF01047.8 MarR 216596006811 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 216596006812 NlpC/P60 family; Region: NLPC_P60; cl17555 216596006813 Pfam match to entry PF00877.8 NLPC_P60 216596006814 amidase; Provisional; Region: PRK07042 216596006815 Amidase; Region: Amidase; cl11426 216596006816 Pfam match to entry PF01425.8 Amidase 216596006817 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 216596006818 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596006819 dimer interface [polypeptide binding]; other site 216596006820 conserved gate region; other site 216596006821 putative PBP binding loops; other site 216596006822 ABC-ATPase subunit interface; other site 216596006823 Pfam match to entry PF00528.10 BPD_transp_1 216596006824 6 probable transmembrane helices predicted at aa 22-44, 90-112, 119-141, 146-168,205-227 and 247-269 216596006825 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 216596006826 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596006827 dimer interface [polypeptide binding]; other site 216596006828 conserved gate region; other site 216596006829 putative PBP binding loops; other site 216596006830 ABC-ATPase subunit interface; other site 216596006831 Pfam match to entry PF00528.10 BPD_transp_1 216596006832 6 probable transmembrane helices predicted at aa 9-31, 97-119, 140-162, 177-199,235-257 and 285-307 216596006833 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 216596006834 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 216596006835 Pfam match to entry PF00496.8 SBP_bac_5 216596006836 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596006837 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596006838 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216596006839 dimerization interface [polypeptide binding]; other site 216596006840 Pfam match to entry PF03466.5 LysR_substrate 216596006841 Pfam match to entry PF00126.10 HTH_1 216596006842 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 216596006843 putative active site pocket [active] 216596006844 cleavage site 216596006845 Pfam match to entry PF03576.3 Peptidase_S58 216596006846 hypothetical protein; Provisional; Region: PRK06149 216596006847 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 216596006848 active site 216596006849 substrate binding site [chemical binding]; other site 216596006850 ATP binding site [chemical binding]; other site 216596006851 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 216596006852 inhibitor-cofactor binding pocket; inhibition site 216596006853 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596006854 catalytic residue [active] 216596006855 Pfam match to entry PF00202.8 Aminotran_3 216596006856 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 216596006857 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 216596006858 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 216596006859 putative active site [active] 216596006860 putative substrate binding site [chemical binding]; other site 216596006861 putative cosubstrate binding site; other site 216596006862 catalytic site [active] 216596006863 Pfam match to entry PF00551.8 Formyl_trans_N 216596006864 Pfam match to entry PF01842.8 ACT 216596006865 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 216596006866 Pfam match to entry PF01757.9 Acyl_transf_3 216596006867 10 probable transmembrane helices predicted at aa 7-25, 35-57, 77-99, 130-152,159-176, 181-203, 208-227, 237-254, 261-283 and 298-320 216596006868 9 probable transmembrane helices predicted at aa 35-57, 61-80, 92-114, 145-167,212-234, 244-275, 282-300, 344-366 and 386-408 216596006869 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 216596006870 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 216596006871 Pfam match to entry PF00150.7 Cellulase 216596006872 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 216596006873 Chain length determinant protein; Region: Wzz; cl15801 216596006874 Pfam match to entry PF02706.5 Wzz 216596006875 2 probable transmembrane helices predicted at aa 106-128 and 497-519 216596006876 Cephalosporin hydroxylase; Region: CmcI; pfam04989 216596006877 Pfam match to entry PF04989.2 CmcI 216596006878 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 216596006879 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 216596006880 inhibitor-cofactor binding pocket; inhibition site 216596006881 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596006882 catalytic residue [active] 216596006883 Pfam match to entry PF01041.7 DegT_DnrJ_EryC1 216596006884 Cephalosporin hydroxylase; Region: CmcI; pfam04989 216596006885 Pfam match to entry PF04989.2 CmcI 216596006886 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 216596006887 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 216596006888 trimer interface [polypeptide binding]; other site 216596006889 active site 216596006890 substrate binding site [chemical binding]; other site 216596006891 CoA binding site [chemical binding]; other site 216596006892 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 216596006893 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 216596006894 active site 216596006895 Pfam match to entry PF00535.10 Glycos_transf_2 216596006896 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 216596006897 Pfam match to entry PF00908.7 dTDP_sugar_isom 216596006898 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 216596006899 Methyltransferase domain; Region: Methyltransf_23; pfam13489 216596006900 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596006901 S-adenosylmethionine binding site [chemical binding]; other site 216596006902 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 216596006903 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 216596006904 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216596006905 NAD(P) binding site [chemical binding]; other site 216596006906 active site 216596006907 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 216596006908 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 216596006909 substrate binding site; other site 216596006910 Pfam match to entry PF00483.9 NTP_transferase 216596006911 BA14K-like protein; Region: BA14K; pfam07886 216596006912 Rdx family; Region: Rdx; cl01407 216596006913 Pfam match to entry PF05169.2 Seleno_W_rel 216596006914 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 216596006915 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 216596006916 catalytic triad [active] 216596006917 Pfam match to entry PF00117.10 GATase 216596006918 maltose O-acetyltransferase; Provisional; Region: PRK10092 216596006919 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 216596006920 active site 216596006921 substrate binding site [chemical binding]; other site 216596006922 trimer interface [polypeptide binding]; other site 216596006923 CoA binding site [chemical binding]; other site 216596006924 Pfam match to entry PF00132.9 Hexapep 216596006925 Pfam match to entry PF00132.9 Hexapep 216596006926 Pfam match to entry PF00132.9 Hexapep 216596006927 Pfam match to entry PF00132.9 Hexapep1 216596006928 Uncharacterized conserved protein [Function unknown]; Region: COG3791 216596006929 Pfam match to entry PF04828.3 DUF636 216596006930 GTP-binding protein LepA; Provisional; Region: PRK05433 216596006931 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 216596006932 G1 box; other site 216596006933 putative GEF interaction site [polypeptide binding]; other site 216596006934 GTP/Mg2+ binding site [chemical binding]; other site 216596006935 Switch I region; other site 216596006936 G2 box; other site 216596006937 G3 box; other site 216596006938 Switch II region; other site 216596006939 G4 box; other site 216596006940 G5 box; other site 216596006941 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 216596006942 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 216596006943 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 216596006944 Pfam match to entry PF06421.1 LepA_C 216596006945 Pfam match to entry PF00679.10 EFG_C 216596006946 Pfam match to entry PF03144.8 GTP_EFTU_D2 216596006947 Pfam match to entry PF00009.10 GTP_EFTU 216596006948 Putative transcription activator [Transcription]; Region: TenA; COG0819 216596006949 Pfam match to entry PF03070.4 TENA_THI-4 216596006950 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 216596006951 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216596006952 non-specific DNA binding site [nucleotide binding]; other site 216596006953 salt bridge; other site 216596006954 sequence-specific DNA binding site [nucleotide binding]; other site 216596006955 Cupin domain; Region: Cupin_2; pfam07883 216596006956 Pfam match to entry PF01381.9 HTH_3 216596006957 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 216596006958 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216596006959 Coenzyme A binding pocket [chemical binding]; other site 216596006960 Pfam match to entry PF00583.9 Acetyltransf_1 216596006961 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 216596006962 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216596006963 motif II; other site 216596006964 Pfam match to entry PF00702.10 Hydrolase 216596006965 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 216596006966 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 216596006967 active site 216596006968 Zn binding site [ion binding]; other site 216596006969 Pfam match to entry PF00850.9 Hist_deacetyl 216596006970 recombination regulator RecX; Reviewed; Region: recX; PRK00117 216596006971 Pfam match to entry PF02631.5 RecX 216596006972 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 216596006973 9 probable transmembrane helices predicted at aa 20-42, 55-77, 87-109, 116-138,161-183, 196-214, 224-246, 253-275 and 279-301 216596006974 Pfam match to entry PF00892.8 DUF6 216596006975 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 216596006976 apolar tunnel; other site 216596006977 heme binding site [chemical binding]; other site 216596006978 dimerization interface [polypeptide binding]; other site 216596006979 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 216596006980 diiron binding motif [ion binding]; other site 216596006981 Uncharacterized conserved protein [Function unknown]; Region: COG1633 216596006982 CCC1-related protein family; Region: CCC1_like_1; cd02437 216596006983 Pfam match to entry PF01988.8 DUF125 216596006984 2 probable transmembrane helices predicted at aa 268-290 and 303-325 216596006985 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035 216596006986 Pfam match to entry PF06035.1 DUF920 216596006987 1 probable transmembrane helix predicted at aa 5-24 216596006988 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216596006989 Serine hydrolase; Region: Ser_hydrolase; cl17834 216596006990 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 216596006991 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 216596006992 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 216596006993 Pfam match to entry PF05198.3 IF3_N 216596006994 Pfam match to entry PF00707.9 IF3_C 216596006995 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 216596006996 Pfam match to entry PF01632.6 Ribosomal_L35p 216596006997 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 216596006998 23S rRNA binding site [nucleotide binding]; other site 216596006999 L21 binding site [polypeptide binding]; other site 216596007000 L13 binding site [polypeptide binding]; other site 216596007001 Pfam match to entry PF00453.7 Ribosomal_L20 216596007002 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 216596007003 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 216596007004 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 216596007005 dimer interface [polypeptide binding]; other site 216596007006 motif 1; other site 216596007007 active site 216596007008 motif 2; other site 216596007009 motif 3; other site 216596007010 Pfam match to entry PF02912.6 Phe_tRNA-synt_N 216596007011 Pfam match to entry PF01409.8 tRNA-synt_2d 216596007012 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 216596007013 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 216596007014 putative tRNA-binding site [nucleotide binding]; other site 216596007015 B3/4 domain; Region: B3_4; pfam03483 216596007016 tRNA synthetase B5 domain; Region: B5; smart00874 216596007017 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 216596007018 dimer interface [polypeptide binding]; other site 216596007019 motif 1; other site 216596007020 motif 3; other site 216596007021 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 216596007022 Pfam match to entry PF01588.6 tRNA_bind 216596007023 Pfam match to entry PF03483.5 B3_4 216596007024 Pfam match to entry PF03484.4 B5 216596007025 Pfam match to entry PF03147.3 FDX-ACB 216596007026 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 216596007027 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 216596007028 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 216596007029 active site 216596007030 catalytic tetrad [active] 216596007031 Pfam match to entry PF00248.9 Aldo_ket_red 216596007032 1 probable transmembrane helix predicted at aa 26-48 216596007033 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596007034 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596007035 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 216596007036 putative effector binding pocket; other site 216596007037 putative dimerization interface [polypeptide binding]; other site 216596007038 Pfam match to entry PF00126.10 HTH_1 216596007039 Pfam match to entry PF03466.5 LysR_substrate 216596007040 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 216596007041 dimerization interface [polypeptide binding]; other site 216596007042 metal binding site [ion binding]; metal-binding site 216596007043 Pfam match to entry PF05974.1 DUF892 216596007044 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 216596007045 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216596007046 Coenzyme A binding pocket [chemical binding]; other site 216596007047 Pfam match to entry PF00583.9 Acetyltransf_1 216596007048 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 216596007049 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 216596007050 active site 216596007051 catalytic tetrad [active] 216596007052 Pfam match to entry PF00248.9 Aldo_ket_red 216596007053 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 216596007054 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 216596007055 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 216596007056 Pfam match to entry PF01408.8 GFO_IDH_MocA 216596007057 Pfam match to entry PF02894.4 GFO_IDH_MocA_C 216596007058 GtrA-like protein; Region: GtrA; pfam04138 216596007059 Pfam match to entry PF04138.2 GtrA 216596007060 4 probable transmembrane helices predicted at aa 7-29, 33-55, 68-90 and 100-122 216596007061 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 216596007062 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 216596007063 Ligand binding site; other site 216596007064 Putative Catalytic site; other site 216596007065 DXD motif; other site 216596007066 2 probable transmembrane helices predicted at aa 233-255 and 270-292 216596007067 Pfam match to entry PF00535.10 Glycos_transf_2 216596007068 11 probable transmembrane helices predicted at aa 31-53, 99-121, 128-150, 208-241,248-270, 285-307, 314-336, 369-391, 398-415, 419-436 and 449-471 216596007069 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 216596007070 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 216596007071 generic binding surface II; other site 216596007072 generic binding surface I; other site 216596007073 Pfam match to entry PF01336.9 tRNA_anti 216596007074 Pfam match to entry PF02601.4 Exonuc_VII_L 216596007075 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 216596007076 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 216596007077 Pfam match to entry PF02525.5 Flavodoxin_2 216596007078 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 216596007079 MarR family; Region: MarR_2; cl17246 216596007080 Pfam match to entry PF01047.8 MarR 216596007081 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 216596007082 EamA-like transporter family; Region: EamA; pfam00892 216596007083 10 probable transmembrane helices predicted at aa 7-29, 34-56, 63-85, 95-114,121-138, 143-165, 172-194, 209-231, 238-257 and 262-279 216596007084 Pfam match to entry PF00892.8 DUF6 216596007085 Pfam match to entry PF00892.8 DUF6 216596007086 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 216596007087 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 216596007088 Pfam match to entry PF02073.5 Peptidase_M29 216596007089 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 216596007090 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 216596007091 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 216596007092 N-terminal domain interface [polypeptide binding]; other site 216596007093 dimer interface [polypeptide binding]; other site 216596007094 substrate binding pocket (H-site) [chemical binding]; other site 216596007095 Pfam match to entry PF00043.11 GST_C 216596007096 Pfam match to entry PF02798.6 GST_N 216596007097 Pfam match to entry PF01047.8 MarR 216596007098 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 216596007099 putative deacylase active site [active] 216596007100 Pfam match to entry PF04073.3 YbaK 216596007101 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 216596007102 ArsC family; Region: ArsC; pfam03960 216596007103 putative catalytic residues [active] 216596007104 Pfam match to entry PF03960.4 ArsC 216596007105 Predicted deacylase [General function prediction only]; Region: COG3608 216596007106 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 216596007107 active site 216596007108 Zn binding site [ion binding]; other site 216596007109 Pfam match to entry PF04952.3 AstE_AspA 216596007110 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 216596007111 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 216596007112 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 216596007113 DNA binding site [nucleotide binding] 216596007114 active site 216596007115 Pfam match to entry PF01035.9 Methyltransf_1 216596007116 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 216596007117 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216596007118 NAD(P) binding site [chemical binding]; other site 216596007119 active site 216596007120 Pfam match to entry PF00106.11 adh_short 216596007121 Agrobacterium tumefaciens protein Atu4866; Region: Atu4866; pfam11512 216596007122 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596007123 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596007124 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 216596007125 putative effector binding pocket; other site 216596007126 putative dimerization interface [polypeptide binding]; other site 216596007127 Pfam match to entry PF00126.10 HTH_1 216596007128 Pfam match to entry PF03466.5 LysR_substrate 216596007129 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 216596007130 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 216596007131 4 probable transmembrane helices predicted at aa 10-32, 45-62, 67-89 and 96-114 216596007132 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596007133 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596007134 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 216596007135 putative effector binding pocket; other site 216596007136 putative dimerization interface [polypeptide binding]; other site 216596007137 Pfam match to entry PF00126.10 HTH_1 216596007138 Pfam match to entry PF03466.5 LysR_substrate 216596007139 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 216596007140 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216596007141 Coenzyme A binding pocket [chemical binding]; other site 216596007142 Pfam match to entry PF00583.9 Acetyltransf_1 216596007143 Helix-turn-helix domain; Region: HTH_18; pfam12833 216596007144 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216596007145 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 216596007146 Pfam match to entry PF00165.8 HTH_AraC 216596007147 Pfam match to entry PF00165.8 HTH_AraC 216596007148 Pfam match to entry PF06445.1 AraC_E_bind 216596007149 Cupin; Region: Cupin_6; pfam12852 216596007150 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216596007151 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216596007152 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216596007153 Pfam match to entry PF00165.8 HTH_AraC 216596007154 Pfam match to entry PF00165.8 HTH_AraC 216596007155 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 216596007156 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 216596007157 active site 216596007158 catalytic tetrad [active] 216596007159 Pfam match to entry PF00248.9 Aldo_ket_red 216596007160 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 216596007161 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 216596007162 NADP binding site [chemical binding]; other site 216596007163 putative substrate binding site [chemical binding]; other site 216596007164 active site 216596007165 RibD C-terminal domain; Region: RibD_C; cl17279 216596007166 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 216596007167 Pfam match to entry PF01872.7 RibD_C 216596007168 Isochorismatase family; Region: Isochorismatase; pfam00857 216596007169 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 216596007170 catalytic triad [active] 216596007171 dimer interface [polypeptide binding]; other site 216596007172 conserved cis-peptide bond; other site 216596007173 Pfam match to entry PF00857.9 Isochorismatase 216596007174 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596007175 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596007176 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 216596007177 putative effector binding pocket; other site 216596007178 dimerization interface [polypeptide binding]; other site 216596007179 Pfam match to entry PF00126.10 HTH_1 216596007180 Pfam match to entry PF03466.5 LysR_substrate 216596007181 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 216596007182 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216596007183 DNA binding site [nucleotide binding] 216596007184 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216596007185 Predicted ATPase [General function prediction only]; Region: COG3903 216596007186 Walker A motif; other site 216596007187 ATP binding site [chemical binding]; other site 216596007188 Walker B motif; other site 216596007189 arginine finger; other site 216596007190 Pfam match to entry PF06492.1 DUF1095 216596007191 Pfam match to entry PF06498.1 Ad_Cycl_assoc 216596007192 Pfam match to entry PF00486.11 Trans_reg_C 216596007193 Domain of unknown function (DUF336); Region: DUF336; pfam03928 216596007194 Pfam match to entry PF03928.3 DUF336 216596007195 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 216596007196 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 216596007197 NAD binding site [chemical binding]; other site 216596007198 substrate binding site [chemical binding]; other site 216596007199 catalytic Zn binding site [ion binding]; other site 216596007200 structural Zn binding site [ion binding]; other site 216596007201 Pfam match to entry PF00107.10 ADH_zinc_N 216596007202 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 216596007203 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 216596007204 potential catalytic triad [active] 216596007205 conserved cys residue [active] 216596007206 Pfam match to entry PF01965.9 DJ-1_PfpI 216596007207 Uncharacterized conserved protein [Function unknown]; Region: COG1359 216596007208 Pfam match to entry PF03992.3 ABM 216596007209 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 216596007210 Uncharacterized ALDH ( RL0313) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_RL0313; cd07148 216596007211 NAD(P) binding site [chemical binding]; other site 216596007212 catalytic residues [active] 216596007213 Pfam match to entry PF00171.9 Aldedh 216596007214 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 216596007215 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596007216 putative substrate translocation pore; other site 216596007217 12 probable transmembrane helices predicted at aa 28-50, 65-87, 94-113, 123-145,152-174, 184-202, 223-245, 260-279, 286-308, 313-335,356-378 and 382-399 216596007218 GMP synthase; Reviewed; Region: guaA; PRK00074 216596007219 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 216596007220 AMP/PPi binding site [chemical binding]; other site 216596007221 candidate oxyanion hole; other site 216596007222 catalytic triad [active] 216596007223 potential glutamine specificity residues [chemical binding]; other site 216596007224 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 216596007225 ATP Binding subdomain [chemical binding]; other site 216596007226 Ligand Binding sites [chemical binding]; other site 216596007227 Dimerization subdomain; other site 216596007228 Pfam match to entry PF00958.9 GMP_synt_C 216596007229 Pfam match to entry PF03054.5 tRNA_Me_trans 216596007230 Pfam match to entry PF00117.10 GATase 216596007231 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06026 216596007232 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, putative; Region: MTA/SAH-nuc-hyp; TIGR01705 216596007233 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 216596007234 CoenzymeA binding site [chemical binding]; other site 216596007235 subunit interaction site [polypeptide binding]; other site 216596007236 PHB binding site; other site 216596007237 Pfam match to entry PF03061.8 4HBT 216596007238 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 216596007239 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3490 216596007240 Pfam match to entry PF07433.1 DUF1513 216596007241 Imelysin; Region: Peptidase_M75; cl09159 216596007242 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 216596007243 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 216596007244 Pfam match to entry PF06537.1 DUF1111 216596007245 Uncharacterized iron-regulated protein [Inorganic ion transport and metabolism]; Region: IrpA; COG3487 216596007246 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 216596007247 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596007248 S-adenosylmethionine binding site [chemical binding]; other site 216596007249 Pfam match to entry PF01189.7 Nol1_Nop2_Fmu 216596007250 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 216596007251 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 216596007252 Pfam match to entry PF03330.5 DPBB_1 216596007253 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 216596007254 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 216596007255 putative NAD(P) binding site [chemical binding]; other site 216596007256 epoxyqueuosine reductase; Region: TIGR00276 216596007257 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 216596007258 Pfam match to entry PF00037.11 Fer4 216596007259 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 216596007260 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 216596007261 C-terminal domain interface [polypeptide binding]; other site 216596007262 GSH binding site (G-site) [chemical binding]; other site 216596007263 dimer interface [polypeptide binding]; other site 216596007264 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 216596007265 N-terminal domain interface [polypeptide binding]; other site 216596007266 dimer interface [polypeptide binding]; other site 216596007267 substrate binding pocket (H-site) [chemical binding]; other site 216596007268 Pfam match to entry PF00043.11 GST_C 216596007269 Pfam match to entry PF02798.6 GST_N 216596007270 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 216596007271 Pfam match to entry PF02673.6 BacA 216596007272 7 probable transmembrane helices predicted at aa 40-62, 77-94, 107-126, 136-155,176-198, 213-235 and 242-264 216596007273 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 216596007274 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 216596007275 putative NAD(P) binding site [chemical binding]; other site 216596007276 active site 216596007277 Uncharacterized conserved protein [Function unknown]; Region: COG5470 216596007278 Pfam match to entry PF07045.1 DUF1330 216596007279 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 216596007280 active site 216596007281 dimer interface [polypeptide binding]; other site 216596007282 Pfam match to entry PF00215.9 OMPdecase 216596007283 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 216596007284 catalytic core [active] 216596007285 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596007286 S-adenosylmethionine binding site [chemical binding]; other site 216596007287 DNA polymerase III subunit beta; Validated; Region: PRK05643 216596007288 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 216596007289 putative DNA binding surface [nucleotide binding]; other site 216596007290 dimer interface [polypeptide binding]; other site 216596007291 beta-clamp/clamp loader binding surface; other site 216596007292 beta-clamp/translesion DNA polymerase binding surface; other site 216596007293 Pfam match to entry PF02768.4 DNA_pol3_beta_3 216596007294 Pfam match to entry PF02767.5 DNA_pol3_beta_2 216596007295 Pfam match to entry PF00712.8 DNA_pol3_beta 216596007296 Predicted methyltransferases [General function prediction only]; Region: COG0313 216596007297 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 216596007298 putative SAM binding site [chemical binding]; other site 216596007299 putative homodimer interface [polypeptide binding]; other site 216596007300 Pfam match to entry PF00590.7 TP_methylase 216596007301 hypothetical protein; Reviewed; Region: PRK12497 216596007302 Pfam match to entry PF02021.6 UPF0102 216596007303 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 216596007304 Pfam match to entry PF05899.1 DUF861 216596007305 glutathione synthetase; Provisional; Region: PRK05246 216596007306 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 216596007307 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 216596007308 Pfam match to entry PF02951.4 GSH-S_N 216596007309 Pfam match to entry PF02955.4 GSH-S_ATP 216596007310 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 216596007311 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 216596007312 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216596007313 Walker A motif; other site 216596007314 ATP binding site [chemical binding]; other site 216596007315 Walker B motif; other site 216596007316 arginine finger; other site 216596007317 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 216596007318 Pfam match to entry PF01078.7 Mg_chelatase 216596007319 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 216596007320 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 216596007321 dimer interface [polypeptide binding]; other site 216596007322 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596007323 catalytic residue [active] 216596007324 Pfam match to entry PF00291.10 PALP 216596007325 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 216596007326 Pfam match to entry PF01810.7 LysE 216596007327 5 probable transmembrane helices predicted at aa 43-65, 78-100, 105-127, 147-169 and 184-206 216596007328 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 216596007329 Ferritin-like domain; Region: Ferritin; pfam00210 216596007330 dimerization interface [polypeptide binding]; other site 216596007331 DPS ferroxidase diiron center [ion binding]; other site 216596007332 ion pore; other site 216596007333 Pfam match to entry PF00210.9 Ferritin 216596007334 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 216596007335 EamA-like transporter family; Region: EamA; pfam00892 216596007336 9 probable transmembrane helices predicted at aa 25-47, 56-78, 83-105, 112-129,144-166, 173-192, 202-224, 231-250 and 255-277 216596007337 Pfam match to entry PF00892.8 DUF6 216596007338 Pfam match to entry PF00892.8 DUF6 216596007339 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 216596007340 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 216596007341 AsnC family; Region: AsnC_trans_reg; pfam01037 216596007342 Pfam match to entry PF01037.8 AsnC_trans_reg 216596007343 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 216596007344 Pfam match to entry PF00583.9 Acetyltransf_1 216596007345 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 216596007346 trimer interface [polypeptide binding]; other site 216596007347 active site 216596007348 Pfam match to entry PF00692.7 dUTPase 216596007349 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 216596007350 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 216596007351 G1 box; other site 216596007352 putative GEF interaction site [polypeptide binding]; other site 216596007353 GTP/Mg2+ binding site [chemical binding]; other site 216596007354 Switch I region; other site 216596007355 G2 box; other site 216596007356 G3 box; other site 216596007357 Switch II region; other site 216596007358 G4 box; other site 216596007359 G5 box; other site 216596007360 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 216596007361 Pfam match to entry PF00009.10 GTP_EFTU 216596007362 Pfam match to entry PF03144.8 GTP_EFTU_D2 216596007363 LysR family transcriptional regulator; Provisional; Region: PRK14997 216596007364 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596007365 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 216596007366 putative effector binding pocket; other site 216596007367 dimerization interface [polypeptide binding]; other site 216596007368 Pfam match to entry PF03466.5 LysR_substrate 216596007369 Pfam match to entry PF00126.10 HTH_1 216596007370 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 216596007371 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 216596007372 C-terminal domain interface [polypeptide binding]; other site 216596007373 GSH binding site (G-site) [chemical binding]; other site 216596007374 dimer interface [polypeptide binding]; other site 216596007375 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 216596007376 dimer interface [polypeptide binding]; other site 216596007377 N-terminal domain interface [polypeptide binding]; other site 216596007378 substrate binding pocket (H-site) [chemical binding]; other site 216596007379 Pfam match to entry PF00043.11 GST_C 216596007380 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 216596007381 homotrimer interaction site [polypeptide binding]; other site 216596007382 putative active site [active] 216596007383 Pfam match to entry PF01042.8 Ribonuc_L-PSP 216596007384 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 216596007385 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216596007386 putative DNA binding site [nucleotide binding]; other site 216596007387 putative Zn2+ binding site [ion binding]; other site 216596007388 AsnC family; Region: AsnC_trans_reg; pfam01037 216596007389 Uncharacterized conserved protein [Function unknown]; Region: COG3791 216596007390 Pfam match to entry PF04828.3 DUF636 216596007391 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 216596007392 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 216596007393 Pfam match to entry PF00450.9 Peptidase_S10 216596007394 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 216596007395 12 probable transmembrane helices predicted at aa 38-60, 75-97, 110-127, 132-154,163-185, 200-219, 240-262, 277-299, 306-325, 330-352,365-387 and 391-413 216596007396 Transcriptional regulators [Transcription]; Region: FadR; COG2186 216596007397 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596007398 DNA-binding site [nucleotide binding]; DNA binding site 216596007399 FCD domain; Region: FCD; pfam07729 216596007400 Pfam match to entry PF00392.9 GntR 216596007401 Pirin-related protein [General function prediction only]; Region: COG1741 216596007402 Pirin; Region: Pirin; pfam02678 216596007403 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 216596007404 Pfam match to entry PF05726.1 Pirin_C 216596007405 Pfam match to entry PF02678.4 Pirin 216596007406 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 216596007407 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 216596007408 putative active site [active] 216596007409 putative dimer interface [polypeptide binding]; other site 216596007410 Pfam match to entry PF00310.9 GATase_2 216596007411 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 216596007412 Flavoprotein; Region: Flavoprotein; pfam02441 216596007413 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 216596007414 Pfam match to entry PF04127.2 DFP 216596007415 Pfam match to entry PF02441.6 Flavoprotein 216596007416 short chain dehydrogenase; Provisional; Region: PRK06500 216596007417 classical (c) SDRs; Region: SDR_c; cd05233 216596007418 NAD(P) binding site [chemical binding]; other site 216596007419 active site 216596007420 Pfam match to entry PF00106.11 adh_short 216596007421 short chain dehydrogenase; Provisional; Region: PRK07478 216596007422 classical (c) SDRs; Region: SDR_c; cd05233 216596007423 NAD(P) binding site [chemical binding]; other site 216596007424 active site 216596007425 Pfam match to entry PF00106.11 adh_short 216596007426 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596007427 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 216596007428 putative effector binding pocket; other site 216596007429 dimerization interface [polypeptide binding]; other site 216596007430 Pfam match to entry PF00126.10 HTH_1 216596007431 Pfam match to entry PF03466.5 LysR_substrate 216596007432 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 216596007433 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596007434 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 216596007435 putative dimerization interface [polypeptide binding]; other site 216596007436 putative substrate binding pocket [chemical binding]; other site 216596007437 Pfam match to entry PF03466.5 LysR_substrate 216596007438 Pfam match to entry PF00126.10 HTH_1 216596007439 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596007440 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216596007441 Pfam match to entry PF00083.9 Sugar_tr 216596007442 12 probable transmembrane helices predicted at aa 35-57, 72-91, 98-120, 124-146,153-175, 185-207, 236-258, 273-295, 302-321, 326-348,360-382 and 386-408 216596007443 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 216596007444 dimer interface [polypeptide binding]; other site 216596007445 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216596007446 metal binding site [ion binding]; metal-binding site 216596007447 Pfam match to entry PF00903.11 Glyoxalase 216596007448 urocanate hydratase; Provisional; Region: PRK05414 216596007449 Pfam match to entry PF01175.7 Urocanase 216596007450 Protein of unknown function (DUF917); Region: DUF917; pfam06032 216596007451 Pfam match to entry PF06032.1 DUF917 216596007452 allantoate amidohydrolase; Reviewed; Region: PRK12893 216596007453 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 216596007454 active site 216596007455 metal binding site [ion binding]; metal-binding site 216596007456 dimer interface [polypeptide binding]; other site 216596007457 Pfam match to entry PF01546.12 Peptidase_M20 216596007458 allantoinase; Region: allantoinase; TIGR03178 216596007459 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 216596007460 active site 216596007461 Pfam match to entry PF01979.7 Amidohydro_1 216596007462 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 216596007463 active sites [active] 216596007464 tetramer interface [polypeptide binding]; other site 216596007465 Pfam match to entry PF00221.7 PAL 216596007466 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 216596007467 ABC1 family; Region: ABC1; pfam03109 216596007468 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 216596007469 active site 216596007470 ATP binding site [chemical binding]; other site 216596007471 Pfam match to entry PF03109.5 ABC1 216596007472 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 216596007473 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596007474 S-adenosylmethionine binding site [chemical binding]; other site 216596007475 Pfam match to entry PF01209.8 Ubie_methyltran 216596007476 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 216596007477 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 216596007478 DNA binding site [nucleotide binding] 216596007479 catalytic residue [active] 216596007480 H2TH interface [polypeptide binding]; other site 216596007481 putative catalytic residues [active] 216596007482 turnover-facilitating residue; other site 216596007483 intercalation triad [nucleotide binding]; other site 216596007484 8OG recognition residue [nucleotide binding]; other site 216596007485 putative reading head residues; other site 216596007486 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 216596007487 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 216596007488 Pfam match to entry PF01149.9 Fapy_DNA_glyco 216596007489 Pfam match to entry PF06831.1 H2TH 216596007490 enoyl-CoA hydratase; Provisional; Region: PRK05862 216596007491 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216596007492 substrate binding site [chemical binding]; other site 216596007493 oxyanion hole (OAH) forming residues; other site 216596007494 trimer interface [polypeptide binding]; other site 216596007495 Pfam match to entry PF00378.8 ECH 216596007496 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 216596007497 Pfam match to entry PF01649.6 Ribosomal_S20p 216596007498 DnaA N-terminal domain; Region: DnaA_N; pfam11638 216596007499 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 216596007500 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216596007501 Walker A motif; other site 216596007502 ATP binding site [chemical binding]; other site 216596007503 Walker B motif; other site 216596007504 arginine finger; other site 216596007505 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 216596007506 DnaA box-binding interface [nucleotide binding]; other site 216596007507 Pfam match to entry PF00308.7 Bac_DnaA 216596007508 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 216596007509 TrkA-N domain; Region: TrkA_N; pfam02254 216596007510 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 216596007511 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 216596007512 FeS/SAM binding site; other site 216596007513 Pfam match to entry PF06969.2 HemN_C 216596007514 Pfam match to entry PF04055.4 Radical_SAM 216596007515 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 216596007516 active site 216596007517 dimerization interface [polypeptide binding]; other site 216596007518 Pfam match to entry PF01725.6 Ham1p_like 216596007519 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 216596007520 putative metal binding site [ion binding]; other site 216596007521 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216596007522 Pfam match to entry PF00903.11 Glyoxalase 216596007523 ribonuclease PH; Reviewed; Region: rph; PRK00173 216596007524 Ribonuclease PH; Region: RNase_PH_bact; cd11362 216596007525 hexamer interface [polypeptide binding]; other site 216596007526 active site 216596007527 Pfam match to entry PF03725.4 RNase_PH_C 216596007528 Pfam match to entry PF01138.10 RNase_PH 216596007529 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 216596007530 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 216596007531 DNA-binding site [nucleotide binding]; DNA binding site 216596007532 Pfam match to entry PF01628.8 HrcA 216596007533 heat shock protein GrpE; Provisional; Region: PRK14141 216596007534 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 216596007535 dimer interface [polypeptide binding]; other site 216596007536 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 216596007537 Pfam match to entry PF01025.7 GrpE 216596007538 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 216596007539 active site 216596007540 tetramer interface [polypeptide binding]; other site 216596007541 Pfam match to entry PF01156.8 IU_nuc_hydro 216596007542 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 216596007543 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 216596007544 putative dimer interface [polypeptide binding]; other site 216596007545 Pfam match to entry PF00011.8 HSP20 216596007546 Uncharacterized small protein [Function unknown]; Region: COG5568 216596007547 Pfam match to entry PF06620.1 DUF1150 216596007548 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 216596007549 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596007550 S-adenosylmethionine binding site [chemical binding]; other site 216596007551 Pfam match to entry PF02390.5 Methyltransf_4 216596007552 S-adenosylmethionine synthetase; Validated; Region: PRK05250 216596007553 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 216596007554 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 216596007555 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 216596007556 Pfam match to entry PF02773.5 S-AdoMet_synt_C 216596007557 Pfam match to entry PF02772.5 S-AdoMet_synt_M 216596007558 Pfam match to entry PF00438.9 S-AdoMet_synt_N 216596007559 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 216596007560 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216596007561 non-specific DNA binding site [nucleotide binding]; other site 216596007562 salt bridge; other site 216596007563 sequence-specific DNA binding site [nucleotide binding]; other site 216596007564 Pfam match to entry PF01381.9 HTH_3 216596007565 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 216596007566 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 216596007567 putative active site [active] 216596007568 catalytic triad [active] 216596007569 putative dimer interface [polypeptide binding]; other site 216596007570 Pfam match to entry PF00795.10 CN_hydrolase 216596007571 7 probable transmembrane helices predicted at aa 17-39, 43-60, 73-95, 110-132,145-167, 187-209 and 216-238 216596007572 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 216596007573 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 216596007574 Transporter associated domain; Region: CorC_HlyC; smart01091 216596007575 Pfam match to entry PF03471.5 CorC_HlyC 216596007576 Pfam match to entry PF00571.13 CBS 216596007577 Pfam match to entry PF00571.13 CBS 216596007578 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 216596007579 Pfam match to entry PF02130.6 UPF0054 216596007580 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 216596007581 PhoH-like protein; Region: PhoH; pfam02562 216596007582 Pfam match to entry PF02562.5 PhoH 216596007583 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 216596007584 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 216596007585 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 216596007586 FeS/SAM binding site; other site 216596007587 TRAM domain; Region: TRAM; cl01282 216596007588 Pfam match to entry PF01938.8 TRAM 216596007589 Pfam match to entry PF04055.4 Radical_SAM 216596007590 Pfam match to entry PF00919.9 UPF0004 216596007591 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 216596007592 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 216596007593 putative acyl-acceptor binding pocket; other site 216596007594 Pfam match to entry PF01553.9 Acyltransferase 216596007595 1 probable transmembrane helix predicted at aa 7-29 216596007596 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 216596007597 metal binding site 2 [ion binding]; metal-binding site 216596007598 putative DNA binding helix; other site 216596007599 metal binding site 1 [ion binding]; metal-binding site 216596007600 dimer interface [polypeptide binding]; other site 216596007601 structural Zn2+ binding site [ion binding]; other site 216596007602 Pfam match to entry PF01475.6 FUR 216596007603 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 216596007604 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216596007605 Coenzyme A binding pocket [chemical binding]; other site 216596007606 Pfam match to entry PF00583.9 Acetyltransf_1 216596007607 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 216596007608 Glycoprotease family; Region: Peptidase_M22; pfam00814 216596007609 Pfam match to entry PF00814.10 Peptidase_M22 216596007610 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 216596007611 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 216596007612 Pfam match to entry PF01106.7 NifU 216596007613 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 216596007614 Ligand Binding Site [chemical binding]; other site 216596007615 Pfam match to entry PF00582.12 Usp 216596007616 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 216596007617 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 216596007618 active site 216596007619 HIGH motif; other site 216596007620 dimer interface [polypeptide binding]; other site 216596007621 KMSKS motif; other site 216596007622 Pfam match to entry PF00579.11 tRNA-synt_1b 216596007623 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 216596007624 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216596007625 Pfam match to entry PF00903.11 Glyoxalase 216596007626 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 216596007627 MviN-like protein; Region: MVIN; pfam03023 216596007628 12 probable transmembrane helices predicted at aa 88-110, 125-147, 159-181,191-213, 233-255, 275-294, 314-336, 351-373, 386-408,413-435, 448-470 and 485-507 216596007629 Pfam match to entry PF03023.4 MVIN 216596007630 PII uridylyl-transferase; Provisional; Region: PRK05092 216596007631 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 216596007632 metal binding triad; other site 216596007633 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 216596007634 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 216596007635 Zn2+ binding site [ion binding]; other site 216596007636 Mg2+ binding site [ion binding]; other site 216596007637 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 216596007638 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 216596007639 Pfam match to entry PF01842.8 ACT 216596007640 Pfam match to entry PF01842.8 ACT 216596007641 Pfam match to entry PF01966.8 HD 216596007642 Pfam match to entry PF01909.9 NTP_transf_2 216596007643 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 216596007644 MutS domain I; Region: MutS_I; pfam01624 216596007645 MutS domain II; Region: MutS_II; pfam05188 216596007646 MutS domain III; Region: MutS_III; pfam05192 216596007647 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 216596007648 Walker A/P-loop; other site 216596007649 ATP binding site [chemical binding]; other site 216596007650 Q-loop/lid; other site 216596007651 ABC transporter signature motif; other site 216596007652 Walker B; other site 216596007653 D-loop; other site 216596007654 H-loop/switch region; other site 216596007655 Pfam match to entry PF00488.9 MutS_V 216596007656 Pfam match to entry PF05192.6 MutS_III 216596007657 Pfam match to entry PF05190.4 MutS_IV 216596007658 Pfam match to entry PF05188.5 MutS_II 216596007659 Pfam match to entry PF01624.9 MutS_I 216596007660 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 216596007661 Malic enzyme, N-terminal domain; Region: malic; pfam00390 216596007662 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 216596007663 putative NAD(P) binding site [chemical binding]; other site 216596007664 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 216596007665 Pfam match to entry PF00390.8 malic 216596007666 Pfam match to entry PF03949.3 Malic_M 216596007667 Pfam match to entry PF01515.8 PTA_PTB 216596007668 Putative hemolysin [General function prediction only]; Region: COG3176 216596007669 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216596007670 dimer interface [polypeptide binding]; other site 216596007671 phosphorylation site [posttranslational modification] 216596007672 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596007673 ATP binding site [chemical binding]; other site 216596007674 Mg2+ binding site [ion binding]; other site 216596007675 G-X-G motif; other site 216596007676 Response regulator receiver domain; Region: Response_reg; pfam00072 216596007677 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596007678 active site 216596007679 phosphorylation site [posttranslational modification] 216596007680 intermolecular recognition site; other site 216596007681 dimerization interface [polypeptide binding]; other site 216596007682 Pfam match to entry PF00072.9 Response_reg 216596007683 Pfam match to entry PF02518.9 HATPase_c 216596007684 Pfam match to entry PF00512.10 HisKA 216596007685 2 probable transmembrane helices predicted at aa 45-64 and 71-93 216596007686 lipoprotein signal peptidase; Provisional; Region: PRK14795 216596007687 lipoprotein signal peptidase; Provisional; Region: PRK14787 216596007688 Pfam match to entry PF01252.7 Peptidase_A8 216596007689 5 probable transmembrane helices predicted at aa 10-32, 45-67, 72-91, 98-120 and 135-156 216596007690 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 216596007691 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 216596007692 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 216596007693 Pfam match to entry PF00588.7 SpoU_methylase 216596007694 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 216596007695 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 216596007696 dimer interface [polypeptide binding]; other site 216596007697 ADP-ribose binding site [chemical binding]; other site 216596007698 active site 216596007699 nudix motif; other site 216596007700 metal binding site [ion binding]; metal-binding site 216596007701 Pfam match to entry PF00293.12 NUDIX 216596007702 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 216596007703 putative hydrophobic ligand binding site [chemical binding]; other site 216596007704 Pfam match to entry PF06240.1 COXG 216596007705 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 216596007706 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216596007707 Coenzyme A binding pocket [chemical binding]; other site 216596007708 Pfam match to entry PF00583.9 Acetyltransf_1 216596007709 2 probable transmembrane helices predicted at aa 7-29 and 49-71 216596007710 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 216596007711 IHF dimer interface [polypeptide binding]; other site 216596007712 IHF - DNA interface [nucleotide binding]; other site 216596007713 Pfam match to entry PF00216.8 Bac_DNA_binding 216596007714 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 216596007715 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 216596007716 tandem repeat interface [polypeptide binding]; other site 216596007717 oligomer interface [polypeptide binding]; other site 216596007718 active site residues [active] 216596007719 Pfam match to entry PF01343.8 Peptidase_S49 216596007720 1 probable transmembrane helix predicted at aa 27-49 216596007721 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 216596007722 1 probable transmembrane helix predicted at aa 36-58 216596007723 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 216596007724 OstA-like protein; Region: OstA; pfam03968 216596007725 Pfam match to entry PF03968.3 OstA 216596007726 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 216596007727 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 216596007728 Walker A/P-loop; other site 216596007729 ATP binding site [chemical binding]; other site 216596007730 Q-loop/lid; other site 216596007731 ABC transporter signature motif; other site 216596007732 Walker B; other site 216596007733 D-loop; other site 216596007734 H-loop/switch region; other site 216596007735 Pfam match to entry PF00005.11 ABC_tran 216596007736 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 216596007737 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 216596007738 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 216596007739 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 216596007740 Pfam match to entry PF00309.9 Sigma54_AID 216596007741 Pfam match to entry PF04963.2 Sigma54_CBD 216596007742 Pfam match to entry PF04552.2 Sigma54_DBD 216596007743 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 216596007744 EamA-like transporter family; Region: EamA; pfam00892 216596007745 10 probable transmembrane helices predicted at aa 56-73, 79-101, 114-136, 140-162,174-196, 200-219, 226-248, 263-285, 297-314 and 319-338 216596007746 Pfam match to entry PF00892.8 DUF6 216596007747 Pfam match to entry PF00892.8 DUF6 216596007748 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 216596007749 30S subunit binding site; other site 216596007750 Pfam match to entry PF02482.6 Ribosomal_S30AE 216596007751 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 216596007752 active site 216596007753 phosphorylation site [posttranslational modification] 216596007754 Pfam match to entry PF00359.10 PTS_EIIA_2 216596007755 Cache domain; Region: Cache_1; pfam02743 216596007756 HAMP domain; Region: HAMP; pfam00672 216596007757 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 216596007758 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216596007759 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 216596007760 dimer interface [polypeptide binding]; other site 216596007761 putative CheW interface [polypeptide binding]; other site 216596007762 Pfam match to entry PF00015.9 MCPsignal 216596007763 Pfam match to entry PF00672.10 HAMP 216596007764 2 probable transmembrane helices predicted at aa 34-56 and 346-368 216596007765 Pfam match to entry PF02743.5 Cache 216596007766 Pfam match to entry PF00672.10 HAMP 216596007767 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 216596007768 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 216596007769 substrate binding site [chemical binding]; other site 216596007770 dimer interface [polypeptide binding]; other site 216596007771 ATP binding site [chemical binding]; other site 216596007772 Pfam match to entry PF00294.10 PfkB 216596007773 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 216596007774 RmuC family; Region: RmuC; pfam02646 216596007775 Pfam match to entry PF02646.5 RmuC 216596007776 1 probable transmembrane helix predicted at aa 15-37 216596007777 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 216596007778 heme-binding site [chemical binding]; other site 216596007779 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216596007780 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 216596007781 dimer interface [polypeptide binding]; other site 216596007782 putative CheW interface [polypeptide binding]; other site 216596007783 Pfam match to entry PF00015.9 MCPsignal 216596007784 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 216596007785 active site 216596007786 catalytic residues [active] 216596007787 metal binding site [ion binding]; metal-binding site 216596007788 Pfam match to entry PF01327.9 Pep_deformylase 216596007789 bifunctional SbtC-like/phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Provisional; Region: PRK13982 216596007790 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 216596007791 oligomeric interface; other site 216596007792 putative active site [active] 216596007793 homodimer interface [polypeptide binding]; other site 216596007794 Pfam match to entry PF01850.8 PIN 216596007795 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 216596007796 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 216596007797 putative active site [active] 216596007798 substrate binding site [chemical binding]; other site 216596007799 putative cosubstrate binding site; other site 216596007800 catalytic site [active] 216596007801 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 216596007802 substrate binding site [chemical binding]; other site 216596007803 Pfam match to entry PF00551.8 Formyl_trans_N 216596007804 Pfam match to entry PF02911.4 Formyl_trans_C 216596007805 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 216596007806 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 216596007807 dimerization interface 3.5A [polypeptide binding]; other site 216596007808 active site 216596007809 Pfam match to entry PF01416.7 PseudoU_synth_1 216596007810 Pfam match to entry PF01416.7 PseudoU_synth_1 216596007811 5 probable transmembrane helices predicted at aa 34-56, 76-98, 111-133, 138-160 and 167-189 216596007812 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 216596007813 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 216596007814 metal binding site [ion binding]; metal-binding site 216596007815 dimer interface [polypeptide binding]; other site 216596007816 Pfam match to entry PF01546.12 Peptidase_M20 216596007817 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 216596007818 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 216596007819 trimer interface [polypeptide binding]; other site 216596007820 active site 216596007821 substrate binding site [chemical binding]; other site 216596007822 CoA binding site [chemical binding]; other site 216596007823 Pfam match to entry PF00132.9 Hexapep 216596007824 Pfam match to entry PF00132.9 Hexapep 216596007825 Pfam match to entry PF00132.9 Hexapep 216596007826 Pfam match to entry PF00132.9 Hexapep 216596007827 Pfam match to entry PF00132.9 Hexapep 216596007828 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 216596007829 Pfam match to entry PF03641.3 Lysine_decarbox 216596007830 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 216596007831 pseudo EF-hand loop; other site 216596007832 peptide binding pocket; other site 216596007833 Ca2+ binding site [ion binding]; other site 216596007834 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 216596007835 Ca2+ binding site [ion binding]; other site 216596007836 Pfam match to entry PF00036.14 efhand 216596007837 Pfam match to entry PF00036.14 efhand 216596007838 Pfam match to entry PF00036.14 efhand 216596007839 Pfam match to entry PF00036.14 efhand 216596007840 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 216596007841 Pfam match to entry PF00702.10 Hydrolase 216596007842 magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026 216596007843 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 216596007844 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 216596007845 FeS/SAM binding site; other site 216596007846 Pfam match to entry PF02310.8 B12-binding 216596007847 Pfam match to entry PF04055.4 Radical_SAM 216596007848 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 216596007849 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 216596007850 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 216596007851 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 216596007852 DNA binding site [nucleotide binding] 216596007853 active site 216596007854 Pfam match to entry PF02805.5 Ada_Zn_binding 216596007855 Pfam match to entry PF01035.9 Methyltransf_1 216596007856 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 216596007857 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 216596007858 tetramer interface [polypeptide binding]; other site 216596007859 active site 216596007860 Mg2+/Mn2+ binding site [ion binding]; other site 216596007861 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 216596007862 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 216596007863 phosphate binding site [ion binding]; other site 216596007864 Pfam match to entry PF01070.7 FMN_dh 216596007865 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 216596007866 homohexameric interface [polypeptide binding]; other site 216596007867 feedback inhibition sensing region; other site 216596007868 carbamate kinase; Reviewed; Region: PRK12686 216596007869 nucleotide binding site [chemical binding]; other site 216596007870 N-acetyl-L-glutamate binding site [chemical binding]; other site 216596007871 Pfam match to entry PF00696.12 AA_kinase 216596007872 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343 216596007873 Anti-sigma-K factor rskA; Region: RskA; pfam10099 216596007874 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 216596007875 Fasciclin domain; Region: Fasciclin; pfam02469 216596007876 Pfam match to entry PF02469.6 Fasciclin 216596007877 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 216596007878 Histidine kinase; Region: HisKA_2; pfam07568 216596007879 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596007880 ATP binding site [chemical binding]; other site 216596007881 Mg2+ binding site [ion binding]; other site 216596007882 G-X-G motif; other site 216596007883 Pfam match to entry PF02518.9 HATPase_c 216596007884 Pfam match to entry PF07536.2 HWE_HK; Pfam match to entry PF07568.1 HisKA_2 216596007885 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 216596007886 DNA-binding site [nucleotide binding]; DNA binding site 216596007887 RNA-binding motif; other site 216596007888 Pfam match to entry PF00313.8 CSD 216596007889 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 216596007890 G1 box; other site 216596007891 GTP/Mg2+ binding site [chemical binding]; other site 216596007892 Switch I region; other site 216596007893 G2 box; other site 216596007894 G3 box; other site 216596007895 Switch II region; other site 216596007896 G4 box; other site 216596007897 G5 box; other site 216596007898 membrane protein insertase; Provisional; Region: PRK01318 216596007899 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 216596007900 Pfam match to entry PF02096.8 60KD_IMP 216596007901 5 probable transmembrane helices predicted at aa 7-26, 373-395, 445-467, 502-519 and 538-560 216596007902 ribonuclease P; Reviewed; Region: rnpA; PRK01313 216596007903 Pfam match to entry PF00825.7 Ribonuclease_P 216596007904 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 216596007905 dimerization interface [polypeptide binding]; other site 216596007906 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216596007907 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 216596007908 dimer interface [polypeptide binding]; other site 216596007909 putative CheW interface [polypeptide binding]; other site 216596007910 2 probable transmembrane helices predicted at aa 7-29 and 183-205 216596007911 Pfam match to entry PF00672.10 HAMP 216596007912 Pfam match to entry PF00015.9 MCPsignal 216596007913 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 216596007914 HAMP domain; Region: HAMP; pfam00672 216596007915 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596007916 ATP binding site [chemical binding]; other site 216596007917 Mg2+ binding site [ion binding]; other site 216596007918 G-X-G motif; other site 216596007919 2 probable transmembrane helices predicted at aa 36-58 and 186-205 216596007920 Pfam match to entry PF00672.10 HAMP 216596007921 Pfam match to entry PF00512.10 HisKA 216596007922 Pfam match to entry PF02518.9 HATPase_c 216596007923 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 216596007924 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 216596007925 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 216596007926 Pfam match to entry PF01609.9 Transposase_11 216596007927 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 216596007928 cyclase homology domain; Region: CHD; cd07302 216596007929 nucleotidyl binding site; other site 216596007930 metal binding site [ion binding]; metal-binding site 216596007931 dimer interface [polypeptide binding]; other site 216596007932 Predicted integral membrane protein [Function unknown]; Region: COG5616 216596007933 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216596007934 TPR repeat; Region: TPR_11; pfam13414 216596007935 TPR motif; other site 216596007936 binding surface 216596007937 Tetratricopeptide repeat; Region: TPR_16; pfam13432 216596007938 Pfam match to entry PF00211.9 Guanylate_cyc 216596007939 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 216596007940 Predicted integral membrane protein [Function unknown]; Region: COG5616 216596007941 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216596007942 binding surface 216596007943 TPR motif; other site 216596007944 2 probable transmembrane helices predicted at aa 21-40 and 60-78 216596007945 protein-export membrane protein SecD; Region: secD; TIGR01129 216596007946 Methyltransferase domain; Region: Methyltransf_23; pfam13489 216596007947 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596007948 S-adenosylmethionine binding site [chemical binding]; other site 216596007949 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596007950 S-adenosylmethionine binding site [chemical binding]; other site 216596007951 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216596007952 Pfam match to entry PF00440.8 TetR_N 216596007953 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 216596007954 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 216596007955 active site 216596007956 catalytic tetrad [active] 216596007957 Pfam match to entry PF00248.9 Aldo_ket_red 216596007958 Protein of unknown function (DUF1684); Region: DUF1684; cl01327 216596007959 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782 216596007960 Pfam match to entry PF05990.1 DUF900 216596007961 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 216596007962 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 216596007963 Pfam match to entry PF01266.8 DAO 216596007964 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 216596007965 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 216596007966 putative NAD(P) binding site [chemical binding]; other site 216596007967 putative active site [active] 216596007968 Pfam match to entry PF00106.11 adh_short 216596007969 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 216596007970 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 216596007971 Pfam match to entry PF05544.1 Pro_racemase 216596007972 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216596007973 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216596007974 Pfam match to entry PF00440.8 TetR_N 216596007975 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 216596007976 classical (c) SDRs; Region: SDR_c; cd05233 216596007977 NAD(P) binding site [chemical binding]; other site 216596007978 active site 216596007979 Pfam match to entry PF00106.11 adh_short 216596007980 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216596007981 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216596007982 Pfam match to entry PF00440.8 TetR_N 216596007983 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 216596007984 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216596007985 NAD(P) binding site [chemical binding]; other site 216596007986 active site 216596007987 Pfam match to entry PF00106.11 adh_short 216596007988 oxidoreductase; Provisional; Region: PRK06196 216596007989 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216596007990 NAD(P) binding site [chemical binding]; other site 216596007991 active site 216596007992 Pfam match to entry PF00106.11 adh_short 216596007993 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 216596007994 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216596007995 metal binding site [ion binding]; metal-binding site 216596007996 active site 216596007997 I-site; other site 216596007998 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216596007999 Pfam match to entry PF00563.9 EAL 216596008000 Pfam match to entry PF00990.8 GGDEF 216596008001 2 probable transmembrane helices predicted at aa 39-56 and 76-95 216596008002 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 216596008003 Pfam match to entry PF05025.2 RbsD_FucU 216596008004 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 216596008005 non-specific DNA interactions [nucleotide binding]; other site 216596008006 DNA binding site [nucleotide binding] 216596008007 sequence specific DNA binding site [nucleotide binding]; other site 216596008008 putative cAMP binding site [chemical binding]; other site 216596008009 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 216596008010 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 216596008011 Pfam match to entry PF00480.8 ROK 216596008012 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 216596008013 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 216596008014 ligand binding site [chemical binding]; other site 216596008015 1 probable transmembrane helix predicted at aa 5-27 216596008016 Pfam match to entry PF00532.8 Peripla_BP_1 216596008017 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596008018 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216596008019 TM-ABC transporter signature motif; other site 216596008020 9 probable transmembrane helices predicted at aa 80-102, 112-131, 138-160,164-186, 193-215, 237-259, 289-308, 344-366 and 373-390 216596008021 Pfam match to entry PF02653.5 BPD_transp_2 216596008022 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 216596008023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216596008024 Walker A/P-loop; other site 216596008025 ATP binding site [chemical binding]; other site 216596008026 Q-loop/lid; other site 216596008027 ABC transporter signature motif; other site 216596008028 Walker B; other site 216596008029 D-loop; other site 216596008030 H-loop/switch region; other site 216596008031 Pfam match to entry PF00005.11 ABC_tran 216596008032 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 216596008033 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 216596008034 active site 216596008035 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 216596008036 active site 216596008037 substrate binding pocket [chemical binding]; other site 216596008038 dimer interface [polypeptide binding]; other site 216596008039 Pfam match to entry PF01979.7 Amidohydro_1 216596008040 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 216596008041 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216596008042 metal binding site [ion binding]; metal-binding site 216596008043 active site 216596008044 I-site; other site 216596008045 6 probable transmembrane helices predicted at aa 20-42, 52-74, 81-100, 135-157,166-188 and 203-225 216596008046 Pfam match to entry PF00990.8 GGDEF 216596008047 Pfam match to entry PF00903.11 Glyoxalase 216596008048 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 216596008049 dimer interface [polypeptide binding]; other site 216596008050 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216596008051 ligand binding site [chemical binding]; other site 216596008052 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 216596008053 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216596008054 active site 216596008055 I-site; other site 216596008056 metal binding site [ion binding]; metal-binding site 216596008057 Pfam match to entry PF00990.8 GGDEF 216596008058 3 probable transmembrane helices predicted at aa 31-53, 63-82 and 94-116 216596008059 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 216596008060 4 probable transmembrane helices predicted at aa 9-31, 61-83, 90-112 and 142-164 216596008061 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216596008062 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 216596008063 NAD(P) binding site [chemical binding]; other site 216596008064 active site 216596008065 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216596008066 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216596008067 Pfam match to entry PF00440.8 TetR_N 216596008068 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 216596008069 active site 216596008070 Pfam match to entry PF00156.11 Pribosyltran 216596008071 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 216596008072 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 216596008073 putative substrate binding site [chemical binding]; other site 216596008074 putative ATP binding site [chemical binding]; other site 216596008075 Pfam match to entry PF00294.10 PfkB 216596008076 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 216596008077 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 216596008078 active site 216596008079 homotetramer interface [polypeptide binding]; other site 216596008080 Pfam match to entry PF00982.8 Glyco_transf_20 216596008081 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 216596008082 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 216596008083 active site 216596008084 dimer interface [polypeptide binding]; other site 216596008085 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 216596008086 dimer interface [polypeptide binding]; other site 216596008087 active site 216596008088 Pfam match to entry PF00342.7 PGI 216596008089 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 216596008090 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 216596008091 acyl-activating enzyme (AAE) consensus motif; other site 216596008092 putative AMP binding site [chemical binding]; other site 216596008093 putative active site [active] 216596008094 putative CoA binding site [chemical binding]; other site 216596008095 Pfam match to entry PF00501.11 AMP-binding 216596008096 PRC-barrel domain; Region: PRC; pfam05239 216596008097 Pfam match to entry PF05239.2 PRC 216596008098 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 216596008099 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 216596008100 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 216596008101 Pfam match to entry PF00703.9 Glyco_hydro_2 216596008102 Pfam match to entry PF02837.6 Glyco_hydro_2_N 216596008103 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216596008104 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 216596008105 dimer interface [polypeptide binding]; other site 216596008106 active site 216596008107 metal binding site [ion binding]; metal-binding site 216596008108 glutathione binding site [chemical binding]; other site 216596008109 Pfam match to entry PF00903.11 Glyoxalase 216596008110 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 216596008111 Pfam match to entry PF00528.10 BPD_transp_1 216596008112 4 probable transmembrane helices predicted at aa 7-29, 56-78, 99-121 and 214-236 216596008113 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 216596008114 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216596008115 Walker A/P-loop; other site 216596008116 ATP binding site [chemical binding]; other site 216596008117 Q-loop/lid; other site 216596008118 ABC transporter signature motif; other site 216596008119 Walker B; other site 216596008120 D-loop; other site 216596008121 H-loop/switch region; other site 216596008122 Pfam match to entry PF00005.11 ABC_tran 216596008123 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 216596008124 Pfam match to entry PF00528.10 BPD_transp_1 216596008125 11 probable transmembrane helices predicted at aa 13-35, 50-72, 79-101, 116-137,144-166, 186-208, 228-250, 260-282, 303-325, 329-351 and 358-380 216596008126 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 216596008127 Pfam match to entry PF04069.2 OpuAC 216596008128 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596008129 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596008130 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596008131 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596008132 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 216596008133 dimerization interface [polypeptide binding]; other site 216596008134 Pfam match to entry PF00126.10 HTH_1 216596008135 Pfam match to entry PF00126.10 HTH_1 216596008136 Pfam match to entry PF03466.5 LysR_substrate 216596008137 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 216596008138 Pfam match to entry PF03932.3 CutC 216596008139 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 216596008140 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 216596008141 putative NAD(P) binding site [chemical binding]; other site 216596008142 catalytic Zn binding site [ion binding]; other site 216596008143 structural Zn binding site [ion binding]; other site 216596008144 Pfam match to entry PF00107.10 ADH_zinc_N 216596008145 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596008146 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216596008147 TM-ABC transporter signature motif; other site 216596008148 8 probable transmembrane helices predicted at aa 21-43, 63-85, 98-120, 125-147,168-190, 219-241, 261-283 and 298-315 216596008149 Pfam match to entry PF02653.5 BPD_transp_2 216596008150 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 216596008151 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 216596008152 Walker A/P-loop; other site 216596008153 ATP binding site [chemical binding]; other site 216596008154 Q-loop/lid; other site 216596008155 ABC transporter signature motif; other site 216596008156 Walker B; other site 216596008157 D-loop; other site 216596008158 H-loop/switch region; other site 216596008159 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 216596008160 Pfam match to entry PF00005.11 ABC_tran 216596008161 Pfam match to entry PF00005.11 ABC_tran 216596008162 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 216596008163 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 216596008164 putative ligand binding site [chemical binding]; other site 216596008165 Pfam match to entry PF00532.8 Peripla_BP_1 216596008166 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 216596008167 Pfam match to entry PF05025.2 RbsD_FucU 216596008168 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 216596008169 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 216596008170 active site 216596008171 catalytic tetrad [active] 216596008172 Pfam match to entry PF00248.9 Aldo_ket_red 216596008173 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 216596008174 galactarate dehydratase; Region: galactar-dH20; TIGR03248 216596008175 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 216596008176 Pfam match to entry PF04295.2 GD_AH_C 216596008177 Pfam match to entry PF04292.2 GD_AH_N 216596008178 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596008179 DNA-binding site [nucleotide binding]; DNA binding site 216596008180 Transcriptional regulators [Transcription]; Region: GntR; COG1802 216596008181 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 216596008182 DNA-binding site [nucleotide binding]; DNA binding site 216596008183 FCD domain; Region: FCD; pfam07729 216596008184 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 216596008185 nucleoside/Zn binding site; other site 216596008186 dimer interface [polypeptide binding]; other site 216596008187 catalytic motif [active] 216596008188 Pfam match to entry PF00383.9 dCMP_cyt_deam 216596008189 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 216596008190 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 216596008191 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 216596008192 5 probable transmembrane helices predicted at aa 77-99, 119-141, 200-222, 227-249 and 325-347 216596008193 Pfam match to entry PF00005.11 ABC_tran 216596008194 Transcriptional regulators [Transcription]; Region: MarR; COG1846 216596008195 MarR family; Region: MarR_2; pfam12802 216596008196 Pfam match to entry PF01047.8 MarR 216596008197 SnoaL-like domain; Region: SnoaL_3; pfam13474 216596008198 SnoaL-like domain; Region: SnoaL_2; pfam12680 216596008199 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596008200 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216596008201 putative substrate translocation pore; other site 216596008202 13 probable transmembrane helices predicted at aa 12-34, 44-66, 78-100, 105-127,140-159, 164-186, 199-216, 220-242, 262-284, 294-316,329-348, 358-377 and 456-478 216596008203 Pfam match to entry PF00083.9 Sugar_tr 216596008204 2 probable transmembrane helices predicted at aa 60-82 and 97-119 216596008205 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 216596008206 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 216596008207 metal-binding site [ion binding] 216596008208 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 216596008209 Soluble P-type ATPase [General function prediction only]; Region: COG4087 216596008210 8 probable transmembrane helices predicted at aa 121-143, 153-175, 187-206,210-229, 364-386, 391-413, 691-710 and 714-736 216596008211 Pfam match to entry PF00702.10 Hydrolase 216596008212 Pfam match to entry PF00122.7 E1-E2_ATPase 216596008213 Pfam match to entry PF00403.12 HMA 216596008214 Predicted integral membrane protein [Function unknown]; Region: COG5473 216596008215 6 probable transmembrane helices predicted at aa 56-78, 83-105, 138-160, 180-202,215-237 and 241-263 216596008216 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 216596008217 Cytochrome c; Region: Cytochrom_C; pfam00034 216596008218 Cytochrome c; Region: Cytochrom_C; pfam00034 216596008219 Pfam match to entry PF00034.8 Cytochrom_C 216596008220 Pfam match to entry PF00034.8 Cytochrom_C 216596008221 1 probable transmembrane helix predicted at aa 32-54 216596008222 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 216596008223 Pfam match to entry PF05545 FixQ 216596008224 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 216596008225 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 216596008226 Pfam match to entry PF02433.5 FixO 216596008227 1 probable transmembrane helix predicted at aa 13-35 216596008228 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 216596008229 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 216596008230 Low-spin heme binding site [chemical binding]; other site 216596008231 Putative water exit pathway; other site 216596008232 Binuclear center (active site) [active] 216596008233 Putative proton exit pathway; other site 216596008234 14 probable transmembrane helices predicted at aa 45-67, 71-93, 113-135, 155-177,189-211, 224-246, 259-281, 301-323, 332-354, 369-391,404-426, 446-468, 481-503 and 531-553 216596008235 Pfam match to entry PF00115.8 COX1 216596008236 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 216596008237 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 216596008238 FMN binding site [chemical binding]; other site 216596008239 substrate binding site [chemical binding]; other site 216596008240 putative catalytic residue [active] 216596008241 Pfam match to entry PF03060.4 NPD 216596008242 1 probable transmembrane helix predicted at aa 171-193 216596008243 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 216596008244 Pfam match to entry PF03976.3 DUF344 216596008245 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 216596008246 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216596008247 dimer interface [polypeptide binding]; other site 216596008248 phosphorylation site [posttranslational modification] 216596008249 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596008250 ATP binding site [chemical binding]; other site 216596008251 Mg2+ binding site [ion binding]; other site 216596008252 G-X-G motif; other site 216596008253 1 probable transmembrane helix predicted at aa 12-34 216596008254 Pfam match to entry PF00512.10 HisKA 216596008255 Pfam match to entry PF02518.9 HATPase_c 216596008256 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 216596008257 putative active site [active] 216596008258 Pfam match to entry PF04480.2 DUF559 216596008259 PBP superfamily domain; Region: PBP_like_2; pfam12849 216596008260 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 216596008261 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 216596008262 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596008263 dimer interface [polypeptide binding]; other site 216596008264 conserved gate region; other site 216596008265 putative PBP binding loops; other site 216596008266 ABC-ATPase subunit interface; other site 216596008267 9 probable transmembrane helices predicted at aa 4-21, 42-64, 157-179, 191-213,254-276, 297-319, 339-361, 393-415 and 462-484 216596008268 Pfam match to entry PF00528.10 BPD_transp_1 216596008269 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 216596008270 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 216596008271 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596008272 dimer interface [polypeptide binding]; other site 216596008273 conserved gate region; other site 216596008274 putative PBP binding loops; other site 216596008275 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 216596008276 ABC-ATPase subunit interface; other site 216596008277 7 probable transmembrane helices predicted at aa 36-58, 225-247, 267-289, 296-318,338-360, 367-386 and 413-432 216596008278 Pfam match to entry PF00528.10 BPD_transp_1 216596008279 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 216596008280 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 216596008281 Walker A/P-loop; other site 216596008282 ATP binding site [chemical binding]; other site 216596008283 Q-loop/lid; other site 216596008284 ABC transporter signature motif; other site 216596008285 Walker B; other site 216596008286 D-loop; other site 216596008287 H-loop/switch region; other site 216596008288 Pfam match to entry PF00005.11 ABC_tran 216596008289 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 216596008290 PhoU domain; Region: PhoU; pfam01895 216596008291 PhoU domain; Region: PhoU; pfam01895 216596008292 Pfam match to entry PF01895.6 PhoU 216596008293 Pfam match to entry PF01895.6 PhoU 216596008294 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 216596008295 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596008296 active site 216596008297 phosphorylation site [posttranslational modification] 216596008298 intermolecular recognition site; other site 216596008299 dimerization interface [polypeptide binding]; other site 216596008300 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216596008301 DNA binding site [nucleotide binding] 216596008302 Pfam match to entry PF00072.9 Response_reg 216596008303 Pfam match to entry PF00486.11 Trans_reg_C 216596008304 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5352 216596008305 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 216596008306 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 216596008307 inhibitor-cofactor binding pocket; inhibition site 216596008308 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596008309 catalytic residue [active] 216596008310 Pfam match to entry PF00202.8 Aminotran_3 216596008311 ornithine carbamoyltransferase; Provisional; Region: PRK00779 216596008312 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 216596008313 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 216596008314 Pfam match to entry PF02729.5 OTCace_N 216596008315 Pfam match to entry PF00185.8 OTCace 216596008316 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 216596008317 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 216596008318 dimerization interface [polypeptide binding]; other site 216596008319 domain crossover interface; other site 216596008320 redox-dependent activation switch; other site 216596008321 Pfam match to entry PF01430.7 HSP33 216596008322 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 216596008323 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 216596008324 Pfam match to entry PF04379.3 DUF525 216596008325 O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504 216596008326 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 216596008327 homodimer interface [polypeptide binding]; other site 216596008328 substrate-cofactor binding pocket; other site 216596008329 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596008330 catalytic residue [active] 216596008331 Pfam match to entry PF01053.8 Cys_Met_Meta_PP 216596008332 2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559 216596008333 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 216596008334 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 216596008335 trimer interface [polypeptide binding]; other site 216596008336 active site 216596008337 Deoxycytidine deaminase [Nucleotide transport and metabolism]; Region: Dcd; COG0717 216596008338 trimer interface [polypeptide binding]; other site 216596008339 active site 216596008340 Pfam match to entry PF06559.1 DCD 216596008341 Protein of unknown function (DUF995); Region: DUF995; pfam06191 216596008342 Pfam match to entry PF06191.1 DUF995 216596008343 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 216596008344 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 216596008345 active site 216596008346 8 probable transmembrane helices predicted at aa 33-52, 62-84, 363-382, 397-415,435-457, 477-499, 506-526 and 541-563 216596008347 Pfam match to entry PF00535.10 Glycos_transf_2 216596008348 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 216596008349 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 216596008350 NAD binding site [chemical binding]; other site 216596008351 homodimer interface [polypeptide binding]; other site 216596008352 active site 216596008353 substrate binding site [chemical binding]; other site 216596008354 Pfam match to entry PF01370.8 Epimerase 216596008355 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 216596008356 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 216596008357 NAD binding site [chemical binding]; other site 216596008358 putative substrate binding site 2 [chemical binding]; other site 216596008359 putative substrate binding site 1 [chemical binding]; other site 216596008360 active site 216596008361 Pfam match to entry PF01370.8 Epimerase 216596008362 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216596008363 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216596008364 Pfam match to entry PF00165.8 HTH_AraC 216596008365 Pfam match to entry PF00165.8 HTH_AraC 216596008366 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216596008367 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 216596008368 Pfam match to entry PF00903.11 Glyoxalase 216596008369 HAMP domain; Region: HAMP; pfam00672 216596008370 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 216596008371 dimer interface [polypeptide binding]; other site 216596008372 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 216596008373 putative CheW interface [polypeptide binding]; other site 216596008374 Pfam match to entry PF00015.9 MCPsignal 216596008375 Pfam match to entry PF00672.10 HAMP 216596008376 2 probable transmembrane helices predicted at aa 11-30 and 185-207 216596008377 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 216596008378 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 216596008379 substrate binding pocket [chemical binding]; other site 216596008380 membrane-bound complex binding site; other site 216596008381 hinge residues; other site 216596008382 1 probable transmembrane helix predicted at aa 13-35 216596008383 Pfam match to entry PF00497.8 SBP_bac_3 216596008384 tellurite resistance protein terB; Region: terB; cd07176 216596008385 putative metal binding site [ion binding]; other site 216596008386 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 216596008387 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 216596008388 Catalytic site; other site 216596008389 Predicted transcriptional regulator [Transcription]; Region: COG2932 216596008390 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 216596008391 Catalytic site [active] 216596008392 Pfam match to entry PF00717.8 Peptidase_S24 216596008393 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 216596008394 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596008395 active site 216596008396 phosphorylation site [posttranslational modification] 216596008397 intermolecular recognition site; other site 216596008398 dimerization interface [polypeptide binding]; other site 216596008399 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216596008400 DNA binding residues [nucleotide binding] 216596008401 dimerization interface [polypeptide binding]; other site 216596008402 Pfam match to entry PF00196.8 GerE 216596008403 Pfam match to entry PF00072.9 Response_reg 216596008404 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502 216596008405 Pfam match to entry PF06108.1 DUF952 216596008406 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 216596008407 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 216596008408 quinone interaction residues [chemical binding]; other site 216596008409 active site 216596008410 catalytic residues [active] 216596008411 FMN binding site [chemical binding]; other site 216596008412 substrate binding site [chemical binding]; other site 216596008413 Pfam match to entry PF01180.11 DHO_dh 216596008414 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 216596008415 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 216596008416 12 probable transmembrane helices predicted at aa 17-39, 54-73, 102-124, 139-161,168-190, 200-222, 243-265, 269-291, 323-345, 360-382,395-412 and 417-436 216596008417 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 216596008418 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 216596008419 2 probable transmembrane helices predicted at aa 20-42 and 62-84 216596008420 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 216596008421 Tetratricopeptide repeat; Region: TPR_1; pfam00515 216596008422 Methyltransferase domain; Region: Methyltransf_12; pfam08242 216596008423 S-adenosylmethionine binding site [chemical binding]; other site 216596008424 Pfam match to entry PF00515.11 TPR 216596008425 Uncharacterized conserved protein [Function unknown]; Region: COG1284 216596008426 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 216596008427 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 216596008428 Pfam match to entry PF02588.4 DUF161 216596008429 6 probable transmembrane helices predicted at aa 34-56, 66-88, 95-114, 129-147,167-189 and 194-211 216596008430 Pfam match to entry PF02588.4 DUF161 216596008431 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 216596008432 putative active site [active] 216596008433 Pfam match to entry PF04480.2 DUF559 216596008434 Uncharacterized conserved protein [Function unknown]; Region: COG2128 216596008435 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 216596008436 Pfam match to entry PF02627.6 CMD 216596008437 Predicted transcriptional regulator [Transcription]; Region: COG1959 216596008438 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216596008439 dimerization interface [polypeptide binding]; other site 216596008440 putative Zn2+ binding site [ion binding]; other site 216596008441 putative DNA binding site [nucleotide binding]; other site 216596008442 Pfam match to entry PF02082.5 Rrf2 216596008443 Uncharacterized conserved protein [Function unknown]; Region: COG1284 216596008444 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 216596008445 Pfam match to entry PF02588.4 DUF161 216596008446 6 probable transmembrane helices predicted at aa 26-48, 58-80, 93-115, 119-136,156-178 and 182-201 216596008447 Pfam match to entry PF02588.4 DUF161 216596008448 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 216596008449 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 216596008450 ATP binding site [chemical binding]; other site 216596008451 putative Mg++ binding site [ion binding]; other site 216596008452 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216596008453 nucleotide binding region [chemical binding]; other site 216596008454 ATP-binding site [chemical binding]; other site 216596008455 DEAD/H associated; Region: DEAD_assoc; pfam08494 216596008456 Pfam match to entry PF00270.12 DEAD 216596008457 Pfam match to entry PF00271.13 Helicase_C 216596008458 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 216596008459 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 216596008460 putative active site [active] 216596008461 putative metal binding site [ion binding]; other site 216596008462 Pfam match to entry PF00149.12 Metallophos 216596008463 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 216596008464 N-acetyl-D-glucosamine binding site [chemical binding]; other site 216596008465 catalytic residue [active] 216596008466 RibD C-terminal domain; Region: RibD_C; cl17279 216596008467 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 216596008468 Pfam match to entry PF01872.7 RibD_C 216596008469 Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; cl09826 216596008470 1 probable transmembrane helix predicted at aa 242-264 216596008471 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 216596008472 8 probable transmembrane helices predicted at aa 5-27, 37-59, 80-102, 112-134,172-194, 204-226, 239-261 and 271-293 216596008473 Pfam match to entry PF01925.8 DUF81 216596008474 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 216596008475 Sel1-like repeats; Region: SEL1; smart00671 216596008476 Sel1-like repeats; Region: SEL1; smart00671 216596008477 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 216596008478 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 216596008479 Pfam match to entry PF01471.6 PG_binding_1 216596008480 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216596008481 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 216596008482 dimer interface [polypeptide binding]; other site 216596008483 putative metal binding site [ion binding]; other site 216596008484 Pfam match to entry PF00903.11 Glyoxalase 216596008485 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 216596008486 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216596008487 NAD(P) binding site [chemical binding]; other site 216596008488 active site 216596008489 Pfam match to entry PF00106.11 adh_short 216596008490 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 216596008491 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 216596008492 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 216596008493 FAD binding site [chemical binding]; other site 216596008494 substrate binding site [chemical binding]; other site 216596008495 catalytic residues [active] 216596008496 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 216596008497 Pfam match to entry PF02770.6 Acyl-CoA_dh_M 216596008498 Pfam match to entry PF00441.11 Acyl-CoA_dh 216596008499 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 216596008500 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 216596008501 dimer interface [polypeptide binding]; other site 216596008502 active site 216596008503 Pfam match to entry PF00108.10 Thiolase_N 216596008504 Pfam match to entry PF02803.5 Thiolase_C 216596008505 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 216596008506 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 216596008507 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216596008508 substrate binding site [chemical binding]; other site 216596008509 oxyanion hole (OAH) forming residues; other site 216596008510 trimer interface [polypeptide binding]; other site 216596008511 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 216596008512 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 216596008513 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 216596008514 Pfam match to entry PF00378.8 ECH 216596008515 Pfam match to entry PF02737.5 3HCDH_N 216596008516 Pfam match to entry PF00725.10 3HCDH 216596008517 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 216596008518 DNA-binding site [nucleotide binding]; DNA binding site 216596008519 RNA-binding motif; other site 216596008520 Pfam match to entry PF00313.8 CSD 216596008521 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 216596008522 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216596008523 dimerization interface [polypeptide binding]; other site 216596008524 putative Zn2+ binding site [ion binding]; other site 216596008525 putative DNA binding site [nucleotide binding]; other site 216596008526 Pfam match to entry PF01047.8 MarR 216596008527 Uncharacterized conserved protein [Function unknown]; Region: COG3791 216596008528 Pfam match to entry PF04828.3 DUF636 216596008529 SnoaL-like domain; Region: SnoaL_3; pfam13474 216596008530 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 216596008531 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596008532 putative substrate translocation pore; other site 216596008533 11 probable transmembrane helices predicted at aa 15-37, 44-66, 81-103, 137-159,163-185, 213-235, 250-269, 276-298, 303-325, 338-360 and 364-386 216596008534 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216596008535 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216596008536 Pfam match to entry PF00440.8 TetR_N 216596008537 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 216596008538 Na binding site [ion binding]; other site 216596008539 PAS fold; Region: PAS_7; pfam12860 216596008540 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 216596008541 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216596008542 dimer interface [polypeptide binding]; other site 216596008543 phosphorylation site [posttranslational modification] 216596008544 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596008545 ATP binding site [chemical binding]; other site 216596008546 Mg2+ binding site [ion binding]; other site 216596008547 G-X-G motif; other site 216596008548 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 216596008549 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596008550 active site 216596008551 phosphorylation site [posttranslational modification] 216596008552 intermolecular recognition site; other site 216596008553 dimerization interface [polypeptide binding]; other site 216596008554 Pfam match to entry PF00072.9 Response_reg 216596008555 Pfam match to entry PF02518.9 HATPase_c 216596008556 Pfam match to entry PF00512.10 HisKA 216596008557 14 probable transmembrane helices predicted at aa 5-24, 44-66, 76-98, 124-146,166-188, 208-227, 252-271, 292-314, 334-356, 394-413,423-445, 452-474, 479-496 and 503-525 216596008558 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 216596008559 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 216596008560 Pfam match to entry PF01741.6 MscL 216596008561 2 probable transmembrane helices predicted at aa 21-43 and 90-112 216596008562 aspartate aminotransferase; Provisional; Region: PRK06108 216596008563 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216596008564 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596008565 homodimer interface [polypeptide binding]; other site 216596008566 catalytic residue [active] 216596008567 Pfam match to entry PF00155.8 Aminotran_1_2 216596008568 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 216596008569 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 216596008570 NAD binding site [chemical binding]; other site 216596008571 homodimer interface [polypeptide binding]; other site 216596008572 active site 216596008573 substrate binding site [chemical binding]; other site 216596008574 Pfam match to entry PF01370.8 Epimerase 216596008575 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]; Region: COG5001 216596008576 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216596008577 metal binding site [ion binding]; metal-binding site 216596008578 active site 216596008579 I-site; other site 216596008580 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216596008581 5 probable transmembrane helices predicted at aa 24-46, 51-73, 93-112, 127-149 and 162-184 216596008582 Pfam match to entry PF00990.8 GGDEF 216596008583 Pfam match to entry PF00563.9 EAL 216596008584 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 216596008585 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216596008586 substrate binding site [chemical binding]; other site 216596008587 oxyanion hole (OAH) forming residues; other site 216596008588 trimer interface [polypeptide binding]; other site 216596008589 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 216596008590 Pfam match to entry PF00378.8 ECH 216596008591 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 216596008592 Part of AAA domain; Region: AAA_19; pfam13245 216596008593 Family description; Region: UvrD_C_2; pfam13538 216596008594 Pfam match to entry PF00580.8 UvrD-helicase 216596008595 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 216596008596 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 216596008597 Protein of unknown function (DUF982); Region: DUF982; pfam06169 216596008598 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 216596008599 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 216596008600 hinge; other site 216596008601 active site 216596008602 Pfam match to entry PF00275.8 EPSP_synthase 216596008603 Protein of unknown function (DUF2948); Region: DUF2948; pfam11164 216596008604 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 216596008605 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 216596008606 NAD binding site [chemical binding]; other site 216596008607 dimerization interface [polypeptide binding]; other site 216596008608 product binding site; other site 216596008609 substrate binding site [chemical binding]; other site 216596008610 zinc binding site [ion binding]; other site 216596008611 catalytic residues [active] 216596008612 Pfam match to entry PF00815.8 Histidinol_dh 216596008613 hypothetical protein; Provisional; Region: PRK02853 216596008614 Pfam match to entry PF06793.1 UPF0262 216596008615 Low molecular weight phosphatase family; Region: LMWPc; cd00115 216596008616 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 216596008617 active site 216596008618 Pfam match to entry PF01451.6 LMWPc 216596008619 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 216596008620 rRNA binding site [nucleotide binding]; other site 216596008621 predicted 30S ribosome binding site; other site 216596008622 Pfam match to entry PF00575.9 S1 216596008623 Maf-like protein; Region: Maf; pfam02545 216596008624 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 216596008625 active site 216596008626 dimer interface [polypeptide binding]; other site 216596008627 Pfam match to entry PF02545.4 Maf 216596008628 zinc-binding protein; Provisional; Region: PRK01343 216596008629 Pfam match to entry PF03884.4 DUF329 216596008630 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 216596008631 Pfam match to entry PF01919.6 DUF79 216596008632 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216596008633 non-specific DNA binding site [nucleotide binding]; other site 216596008634 salt bridge; other site 216596008635 sequence-specific DNA binding site [nucleotide binding]; other site 216596008636 Pfam match to entry PF01381.9 HTH_3 216596008637 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 216596008638 DNA-binding interface [nucleotide binding]; DNA binding site 216596008639 Pfam match to entry PF01527.7 Transposase_8 216596008640 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 216596008641 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 216596008642 HlyD family secretion protein; Region: HlyD_3; pfam13437 216596008643 Pfam match to entry PF00529.8 HlyD 216596008644 1 probable transmembrane helix predicted at aa 65-87 216596008645 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 216596008646 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216596008647 Walker A/P-loop; other site 216596008648 ATP binding site [chemical binding]; other site 216596008649 Q-loop/lid; other site 216596008650 ABC transporter signature motif; other site 216596008651 Walker B; other site 216596008652 D-loop; other site 216596008653 H-loop/switch region; other site 216596008654 Pfam match to entry PF00005.11 ABC_tran 216596008655 Pfam match to entry PF00664.9 ABC_membrane 216596008656 3 probable transmembrane helices predicted at aa 26-48, 63-80 and 149-171 216596008657 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 216596008658 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216596008659 DNA binding residues [nucleotide binding] 216596008660 dimerization interface [polypeptide binding]; other site 216596008661 Pfam match to entry PF00196.8 GerE 216596008662 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 216596008663 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216596008664 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216596008665 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216596008666 Pfam match to entry PF00165.8 HTH_AraC 216596008667 Pfam match to entry PF00165.8 HTH_AraC 216596008668 Pfam match to entry PF02311.7 AraC_binding 216596008669 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 216596008670 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 216596008671 ligand binding site [chemical binding]; other site 216596008672 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 216596008673 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 216596008674 Walker A/P-loop; other site 216596008675 ATP binding site [chemical binding]; other site 216596008676 Q-loop/lid; other site 216596008677 ABC transporter signature motif; other site 216596008678 Walker B; other site 216596008679 D-loop; other site 216596008680 H-loop/switch region; other site 216596008681 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 216596008682 Pfam match to entry PF00005.11 ABC_tran 216596008683 Pfam match to entry PF00005.11 ABC_tran 216596008684 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216596008685 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596008686 TM-ABC transporter signature motif; other site 216596008687 9 probable transmembrane helices predicted at aa 25-47, 52-74, 81-103, 108-130,137-158, 178-200, 231-253, 258-280 and 282-304 216596008688 Pfam match to entry PF02653.5 BPD_transp_2 216596008689 L-arabinose isomerase [Carbohydrate transport and metabolism]; Region: AraA; COG2160 216596008690 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 216596008691 hexamer (dimer of trimers) interface [polypeptide binding]; other site 216596008692 trimer interface [polypeptide binding]; other site 216596008693 substrate binding site [chemical binding]; other site 216596008694 Mn binding site [ion binding]; other site 216596008695 short chain dehydrogenase; Provisional; Region: PRK07060 216596008696 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216596008697 NAD(P) binding site [chemical binding]; other site 216596008698 active site 216596008699 Pfam match to entry PF00106.11 adh_short 216596008700 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 216596008701 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 216596008702 Walker A/P-loop; other site 216596008703 ATP binding site [chemical binding]; other site 216596008704 Q-loop/lid; other site 216596008705 ABC transporter signature motif; other site 216596008706 Walker B; other site 216596008707 D-loop; other site 216596008708 H-loop/switch region; other site 216596008709 TOBE domain; Region: TOBE_2; pfam08402 216596008710 Pfam match to entry PF03459.4 TOBE 216596008711 Pfam match to entry PF00005.11 ABC_tran 216596008712 Predicted small integral membrane protein (DUF2160); Region: DUF2160; cl02294 216596008713 2 probable transmembrane helices predicted at aa 21-43 and 47-66 216596008714 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216596008715 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596008716 dimer interface [polypeptide binding]; other site 216596008717 conserved gate region; other site 216596008718 putative PBP binding loops; other site 216596008719 ABC-ATPase subunit interface; other site 216596008720 Pfam match to entry PF00528.10 BPD_transp_1 216596008721 6 probable transmembrane helices predicted at aa 7-29, 70-92, 105-127, 142-164,185-207 and 241-263 216596008722 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 216596008723 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596008724 dimer interface [polypeptide binding]; other site 216596008725 conserved gate region; other site 216596008726 putative PBP binding loops; other site 216596008727 ABC-ATPase subunit interface; other site 216596008728 Pfam match to entry PF00528.10 BPD_transp_1 216596008729 6 probable transmembrane helices predicted at aa 7-29, 67-89, 110-132, 162-181,198-220 and 263-285 216596008730 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 216596008731 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 216596008732 Pfam match to entry PF01547.11 SBP_bac_1 216596008733 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 216596008734 Pfam match to entry PF01261.10 AP_endonuc_2 216596008735 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 216596008736 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 216596008737 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 216596008738 nucleotide binding site [chemical binding]; other site 216596008739 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 216596008740 Pfam match to entry PF00480.8 ROK 216596008741 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 216596008742 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 216596008743 substrate binding site [chemical binding]; other site 216596008744 ATP binding site [chemical binding]; other site 216596008745 Pfam match to entry PF00294.10 PfkB 216596008746 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; pfam08013 216596008747 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 216596008748 classical (c) SDRs; Region: SDR_c; cd05233 216596008749 NAD(P) binding site [chemical binding]; other site 216596008750 active site 216596008751 Pfam match to entry PF00106.11 adh_short 216596008752 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216596008753 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 216596008754 NAD(P) binding site [chemical binding]; other site 216596008755 active site 216596008756 Pfam match to entry PF00106.11 adh_short 216596008757 1 probable transmembrane helix predicted at aa 228-250 216596008758 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 216596008759 Class I aldolases; Region: Aldolase_Class_I; cl17187 216596008760 catalytic residue [active] 216596008761 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 216596008762 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 216596008763 Pfam match to entry PF01408.8 GFO_IDH_MocA 216596008764 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 216596008765 Pfam match to entry PF07385.1 DUF1498 216596008766 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 216596008767 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 216596008768 substrate binding site [chemical binding]; other site 216596008769 ATP binding site [chemical binding]; other site 216596008770 Pfam match to entry PF00294.10 PfkB 216596008771 sorbitol dehydrogenase; Provisional; Region: PRK07067 216596008772 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216596008773 NAD(P) binding site [chemical binding]; other site 216596008774 active site 216596008775 Pfam match to entry PF00106.11 adh_short 216596008776 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 216596008777 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 216596008778 putative NAD(P) binding site [chemical binding]; other site 216596008779 catalytic Zn binding site [ion binding]; other site 216596008780 Pfam match to entry PF00107.10 ADH_zinc_N 216596008781 Transcriptional regulators [Transcription]; Region: PurR; COG1609 216596008782 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216596008783 DNA binding site [nucleotide binding] 216596008784 domain linker motif; other site 216596008785 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 216596008786 dimerization interface [polypeptide binding]; other site 216596008787 ligand binding site [chemical binding]; other site 216596008788 Pfam match to entry PF00532.8 Peripla_BP_1 216596008789 Pfam match to entry PF00356.8 LacI 216596008790 biosynthesis cluster domain; Region: biosyn_clust_1; TIGR04098 216596008791 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 216596008792 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 216596008793 MSMEG_0570 family protein; Region: MSMEG_0570_fam; TIGR04042 216596008794 glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047 216596008795 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 216596008796 Pfam match to entry PF00534.8 Glycos_transf_1 216596008797 AIR synthase-related protein, sll0787 family; Region: AIR_rel_sll0787; TIGR04049 216596008798 AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like3; cd02192 216596008799 dimerization interface [polypeptide binding]; other site 216596008800 putative ATP binding site [chemical binding]; other site 216596008801 Pfam match to entry PF02769.9 AIRS_C 216596008802 Pfam match to entry PF00586.11 AIRS 216596008803 putative N-acetyltransferase, MSMEG_0567 N-terminal domain family; Region: MSMEG_0567_GNAT; TIGR04045 216596008804 Pfam match to entry PF00583.9 Acetyltransf_1 216596008805 radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043 216596008806 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 216596008807 FeS/SAM binding site; other site 216596008808 Pfam match to entry PF04055.4 Radical_SAM 216596008809 Predicted amidohydrolase [General function prediction only]; Region: COG0388 216596008810 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 216596008811 putative active site [active] 216596008812 catalytic triad [active] 216596008813 putative dimer interface [polypeptide binding]; other site 216596008814 Pfam match to entry PF00795.10 CN_hydrolase 216596008815 MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044 216596008816 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216596008817 Right handed beta helix region; Region: Beta_helix; pfam13229 216596008818 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 216596008819 Pfam match to entry PF01757.9 Acyl_transf_3 216596008820 10 probable transmembrane helices predicted at aa 13-32, 42-64, 84-106, 116-137,168-187, 202-224, 231-253, 263-285, 298-315 and 325-347 216596008821 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 216596008822 O-Antigen ligase; Region: Wzy_C; pfam04932 216596008823 9 probable transmembrane helices predicted at aa 30-52, 67-86, 99-121, 155-176,197-214, 224-246, 267-289, 355-377 and 398-420 216596008824 Pfam match to entry PF04932.3 Wzy_C 216596008825 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 216596008826 active site 216596008827 catalytic triad [active] 216596008828 oxyanion hole [active] 216596008829 Pfam match to entry PF00657.10 Lipase_GDSL 216596008830 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 216596008831 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 216596008832 Pfam match to entry PF02566.5 OsmC 216596008833 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 216596008834 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 216596008835 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 216596008836 EamA-like transporter family; Region: EamA; pfam00892 216596008837 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 216596008838 EamA-like transporter family; Region: EamA; pfam00892 216596008839 10 probable transmembrane helices predicted at aa 17-36, 46-63, 75-97, 107-126,133-155, 165-183, 192-211, 221-243, 250-272 and 276-294 216596008840 Pfam match to entry PF00892.8 DUF6 216596008841 Pfam match to entry PF00892.8 DUF6 216596008842 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 216596008843 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216596008844 Zn binding site [ion binding]; other site 216596008845 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 216596008846 Zn binding site [ion binding]; other site 216596008847 Predicted esterase [General function prediction only]; Region: COG0400 216596008848 Pfam match to entry PF00903.11 Glyoxalase 216596008849 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596008850 Response regulator receiver domain; Region: Response_reg; pfam00072 216596008851 active site 216596008852 phosphorylation site [posttranslational modification] 216596008853 intermolecular recognition site; other site 216596008854 dimerization interface [polypeptide binding]; other site 216596008855 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216596008856 dimer interface [polypeptide binding]; other site 216596008857 phosphorylation site [posttranslational modification] 216596008858 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596008859 ATP binding site [chemical binding]; other site 216596008860 Mg2+ binding site [ion binding]; other site 216596008861 G-X-G motif; other site 216596008862 Response regulator receiver domain; Region: Response_reg; pfam00072 216596008863 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596008864 active site 216596008865 phosphorylation site [posttranslational modification] 216596008866 intermolecular recognition site; other site 216596008867 dimerization interface [polypeptide binding]; other site 216596008868 Pfam match to entry PF00072.9 Response_reg 216596008869 Pfam match to entry PF02518.9 HATPase_c 216596008870 Pfam match to entry PF00512.10 HisKA 216596008871 Pfam match to entry PF00072.9 Response_reg 216596008872 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 216596008873 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596008874 active site 216596008875 phosphorylation site [posttranslational modification] 216596008876 intermolecular recognition site; other site 216596008877 dimerization interface [polypeptide binding]; other site 216596008878 Pfam match to entry PF00072.9 Response_reg 216596008879 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 216596008880 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216596008881 putative active site [active] 216596008882 heme pocket [chemical binding]; other site 216596008883 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216596008884 dimer interface [polypeptide binding]; other site 216596008885 phosphorylation site [posttranslational modification] 216596008886 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596008887 ATP binding site [chemical binding]; other site 216596008888 Mg2+ binding site [ion binding]; other site 216596008889 G-X-G motif; other site 216596008890 Pfam match to entry PF02518.9 HATPase_c 216596008891 Pfam match to entry PF00512.10 HisKA 216596008892 Pfam match to entry PF00785.11 PAC 216596008893 Pfam match to entry PF00989.11 PAS 216596008894 10 probable transmembrane helices predicted at aa 74-96, 111-133, 140-162, 186-208,221-238, 248-270, 283-300, 304-322, 329-346 and 361-378 216596008895 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596008896 Response regulator receiver domain; Region: Response_reg; pfam00072 216596008897 active site 216596008898 phosphorylation site [posttranslational modification] 216596008899 intermolecular recognition site; other site 216596008900 dimerization interface [polypeptide binding]; other site 216596008901 Pfam match to entry PF00072.9 Response_reg 216596008902 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216596008903 DNA binding residues [nucleotide binding] 216596008904 dimerization interface [polypeptide binding]; other site 216596008905 Pfam match to entry PF00196.8 GerE 216596008906 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 216596008907 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596008908 active site 216596008909 phosphorylation site [posttranslational modification] 216596008910 intermolecular recognition site; other site 216596008911 dimerization interface [polypeptide binding]; other site 216596008912 Pfam match to entry PF00072.9 Response_reg 216596008913 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 216596008914 dimer interface [polypeptide binding]; other site 216596008915 phosphorylation site [posttranslational modification] 216596008916 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596008917 ATP binding site [chemical binding]; other site 216596008918 Mg2+ binding site [ion binding]; other site 216596008919 G-X-G motif; other site 216596008920 Pfam match to entry PF02518.9 HATPase_c 216596008921 Pfam match to entry PF00512.10 HisKA 216596008922 bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726 216596008923 SecD export protein N-terminal TM region; Region: SecD-TM1; cl08136 216596008924 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 216596008925 Protein export membrane protein; Region: SecD_SecF; pfam02355 216596008926 Pfam match to entry PF02355.6 SecD_SecF 216596008927 12 probable transmembrane helices predicted at aa 7-29, 356-378, 383-405, 409-431,452-474, 484-506, 541-563, 657-679, 686-708, 713-735,765-784 and 794-816 216596008928 Pfam match to entry PF07549.1 Sec_GG 216596008929 Pfam match to entry PF07549.1 Sec_GG 216596008930 1 probable transmembrane helix predicted at aa 21-43 216596008931 putative cation:proton antiport protein; Provisional; Region: PRK10669 216596008932 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 216596008933 TrkA-N domain; Region: TrkA_N; pfam02254 216596008934 Pfam match to entry PF02254.5 TrkA_N 216596008935 12 probable transmembrane helices predicted at aa 5-27, 34-53, 57-79, 88-110,115-137, 150-172, 199-221, 241-275, 295-313, 320-342,357-376 and 383-400 216596008936 Pfam match to entry PF00999.9 Na_H_Exchanger 216596008937 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216596008938 non-specific DNA binding site [nucleotide binding]; other site 216596008939 salt bridge; other site 216596008940 sequence-specific DNA binding site [nucleotide binding]; other site 216596008941 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 216596008942 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 216596008943 10 probable transmembrane helices predicted at aa 7-29, 69-88, 101-120, 124-141,148-170, 185-207, 235-257, 272-291, 293-315 and 325-347 216596008944 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 216596008945 heme-binding site [chemical binding]; other site 216596008946 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216596008947 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 216596008948 dimer interface [polypeptide binding]; other site 216596008949 putative CheW interface [polypeptide binding]; other site 216596008950 Pfam match to entry PF00015.9 MCPsignal 216596008951 STAS domain; Region: STAS_2; pfam13466 216596008952 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 216596008953 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596008954 active site 216596008955 phosphorylation site [posttranslational modification] 216596008956 intermolecular recognition site; other site 216596008957 dimerization interface [polypeptide binding]; other site 216596008958 Pfam match to entry PF00072.9 Response_reg 216596008959 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 216596008960 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 216596008961 putative binding surface; other site 216596008962 active site 216596008963 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 216596008964 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596008965 ATP binding site [chemical binding]; other site 216596008966 Mg2+ binding site [ion binding]; other site 216596008967 G-X-G motif; other site 216596008968 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 216596008969 Pfam match to entry PF01627.9 Hpt 216596008970 Pfam match to entry PF02895.4 H-kinase_dim 216596008971 Pfam match to entry PF02518.9 HATPase_c 216596008972 Pfam match to entry PF01584.7 CheW 216596008973 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 216596008974 putative CheA interaction surface; other site 216596008975 Pfam match to entry PF01584.7 CheW 216596008976 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 216596008977 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 216596008978 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 216596008979 Pfam match to entry PF03705.5 CheR_N 216596008980 Pfam match to entry PF01739.8 CheR 216596008981 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 216596008982 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596008983 active site 216596008984 phosphorylation site [posttranslational modification] 216596008985 intermolecular recognition site; other site 216596008986 dimerization interface [polypeptide binding]; other site 216596008987 CheB methylesterase; Region: CheB_methylest; pfam01339 216596008988 Pfam match to entry PF00072.9 Response_reg 216596008989 Pfam match to entry PF01339.7 CheB_methylest 216596008990 Response regulator receiver domain; Region: Response_reg; pfam00072 216596008991 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596008992 active site 216596008993 phosphorylation site [posttranslational modification] 216596008994 intermolecular recognition site; other site 216596008995 dimerization interface [polypeptide binding]; other site 216596008996 Pfam match to entry PF00072.9 Response_reg 216596008997 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13497 216596008998 Pfam match to entry PF03975.3 CheD 216596008999 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 216596009000 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 216596009001 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 216596009002 Pfam match to entry PF01514.7 YscJ_FliF 216596009003 2 probable transmembrane helices predicted at aa 21-43 and 437-459 216596009004 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 216596009005 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216596009006 DNA binding residues [nucleotide binding] 216596009007 dimerization interface [polypeptide binding]; other site 216596009008 Pfam match to entry PF00196.8 GerE 216596009009 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 216596009010 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216596009011 DNA binding residues [nucleotide binding] 216596009012 dimerization interface [polypeptide binding]; other site 216596009013 Pfam match to entry PF00196.8 GerE 216596009014 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 216596009015 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 216596009016 Pfam match to entry PF01312.7 Bac_export_2 216596009017 4 probable transmembrane helices predicted at aa 60-82, 109-131, 170-192 and 221-240 216596009018 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 216596009019 FliG C-terminal domain; Region: FliG_C; pfam01706 216596009020 Pfam match to entry PF01706.6 FliG_C 216596009021 flagellar motor switch protein FliN; Region: fliN; TIGR02480 216596009022 Pfam match to entry PF01052.8 SpoA 216596009023 Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868 216596009024 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 216596009025 Pfam match to entry PF01052.8 SpoA 216596009026 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 216596009027 flagellar motor protein MotA; Validated; Region: PRK09110 216596009028 4 probable transmembrane helices predicted at aa 3-22, 27-49, 172-191 and 201-223 216596009029 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12642 216596009030 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 216596009031 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 216596009032 Pfam match to entry PF00460.8 Flg_bb_rod 216596009033 Pfam match to entry PF06429.1 DUF1078 216596009034 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06002 216596009035 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 216596009036 Walker A motif; other site 216596009037 ATP binding site [chemical binding]; other site 216596009038 Walker B motif; other site 216596009039 Pfam match to entry PF00006.9 ATP-synt_ab 216596009040 1 probable transmembrane helix predicted at aa 21-43 216596009041 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06003 216596009042 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK12782 216596009043 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 216596009044 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 216596009045 Pfam match to entry PF00460.8 Flg_bb_rod 216596009046 Pfam match to entry PF06429.1 DUF1078 216596009047 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00790 216596009048 Pfam match to entry PF02049.6 FliE 216596009049 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691 216596009050 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 216596009051 Pfam match to entry PF00460.8 Flg_bb_rod 216596009052 Pfam match to entry PF06429.1 DUF1078 216596009053 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 216596009054 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 216596009055 Pfam match to entry PF03240.3 FlgA 216596009056 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 216596009057 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 216596009058 1 probable transmembrane helix predicted at aa 7-29 216596009059 Pfam match to entry PF02119.5 FlgI 216596009060 Uncharacterized conserved protein [Function unknown]; Region: COG3334 216596009061 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 216596009062 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 216596009063 Pfam match to entry PF02107.5 FlgH 216596009064 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 216596009065 Pfam match to entry PF03748.3 FliL 216596009066 1 probable transmembrane helix predicted at aa 20-42 216596009067 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 216596009068 4 probable transmembrane helices predicted at aa 5-23, 38-60, 186-208 and 218-240 216596009069 Pfam match to entry PF00813.7 FliP 216596009070 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 216596009071 TPR motif; other site 216596009072 binding surface 216596009073 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 216596009074 flagellin; Reviewed; Region: PRK12687 216596009075 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 216596009076 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 216596009077 Pfam match to entry PF00669.8 Flagellin_N 216596009078 Pfam match to entry PF00700.8 Flagellin_C 216596009079 flagellin; Reviewed; Region: PRK12687 216596009080 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 216596009081 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 216596009082 Pfam match to entry PF00669.8 Flagellin_N 216596009083 Pfam match to entry PF00700.8 Flagellin_C 216596009084 Signal peptide predicted for RL0720 by SignalP 2.0 HMM (Signal peptide probabilty 0.672) with cleavage site probability 0.658 between residues 30 and 31 216596009085 flagellin; Reviewed; Region: PRK12687 216596009086 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 216596009087 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 216596009088 Pfam match to entry PF00669.8 Flagellin_N 216596009089 Pfam match to entry PF00700.8 Flagellin_C 216596009090 flagellin; Reviewed; Region: PRK12687 216596009091 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 216596009092 Pfam match to entry PF00669.8 Flagellin_N 216596009093 flagellar motor protein MotB; Validated; Region: motB; PRK05996 216596009094 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 216596009095 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 216596009096 ligand binding site [chemical binding]; other site 216596009097 1 probable transmembrane helix predicted at aa 35-57 216596009098 Pfam match to entry PF00691.7 OmpA 216596009099 chemotaxis protein; Reviewed; Region: PRK12798 216596009100 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 216596009101 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 216596009102 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 216596009103 N-acetyl-D-glucosamine binding site [chemical binding]; other site 216596009104 Pfam match to entry PF01464.7 SLT 216596009105 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 216596009106 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216596009107 DNA binding site [nucleotide binding] 216596009108 Pfam match to entry PF00072.9 Response_reg 216596009109 Pfam match to entry PF00486.11 Trans_reg_C 216596009110 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 216596009111 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 216596009112 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 216596009113 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 216596009114 Pfam match to entry PF00460.8 Flg_bb_rod 216596009115 Pfam match to entry PF07559.1 FlaE 216596009116 Pfam match to entry PF06429.1 DUF1078 216596009117 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521 216596009118 Pfam match to entry PF06429.1 DUF1078 216596009119 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008 216596009120 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 216596009121 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 216596009122 Pfam match to entry PF07164.1 HAP3 216596009123 Flagellar biosynthesis regulator FlaF [Cell motility and secretion]; Region: FlaF; COG5442 216596009124 flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12793 216596009125 Pfam match to entry PF07309.1 FlaF 216596009126 Flagellar biosynthesis regulator FlbT [Cell motility and secretion]; Region: FlbT; COG5443 216596009127 Pfam match to entry PF07378.1 FlbT 216596009128 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06009 216596009129 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 216596009130 Pfam match to entry PF03963.3 FlgD 216596009131 flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK06010 216596009132 Pfam match to entry PF01313.7 Bac_export_3 216596009133 2 probable transmembrane helices predicted at aa 13-35 and 55-77 216596009134 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 216596009135 FHIPEP family; Region: FHIPEP; pfam00771 216596009136 7 probable transmembrane helices predicted at aa 19-41, 45-62, 74-96, 116-138,206-228, 248-270 and 291-313 216596009137 Pfam match to entry PF00771.7 FHIPEP 216596009138 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 216596009139 Pfam match to entry PF01311.8 Bac_export_1 216596009140 7 probable transmembrane helices predicted at aa 10-31, 38-55, 65-87, 92-109,124-146, 181-203 and 218-240 216596009141 Rod binding protein; Region: Rod-binding; pfam10135 216596009142 2 probable transmembrane helices predicted at aa 7-28 and 48-70 216596009143 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 216596009144 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 216596009145 Pfam match to entry PF03808.3 Glyco_tran_WecB 216596009146 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 216596009147 2 probable transmembrane helices predicted at aa 102-124 and 479-501 216596009148 Pfam match to entry PF02706.5 Wzz 216596009149 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 216596009150 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 216596009151 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 216596009152 homodimer interface [polypeptide binding]; other site 216596009153 NADP binding site [chemical binding]; other site 216596009154 substrate binding site [chemical binding]; other site 216596009155 Pfam match to entry PF00763.10 THF_DHG_CYH 216596009156 Pfam match to entry PF02882.6 THF_DHG_CYH_C 216596009157 Transcriptional regulators [Transcription]; Region: PurR; COG1609 216596009158 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216596009159 DNA binding site [nucleotide binding] 216596009160 domain linker motif; other site 216596009161 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 216596009162 ligand binding site [chemical binding]; other site 216596009163 Pfam match to entry PF00532.8 Peripla_BP_1 216596009164 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 216596009165 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 216596009166 Pfam match to entry PF01547.11 SBP_bac_1 216596009167 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 216596009168 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 216596009169 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596009170 putative PBP binding loops; other site 216596009171 dimer interface [polypeptide binding]; other site 216596009172 ABC-ATPase subunit interface; other site 216596009173 7 probable transmembrane helices predicted at aa 5-27, 59-81, 114-133, 146-163,203-225, 255-277 and 305-327 216596009174 Pfam match to entry PF00528.10 BPD_transp_1 216596009175 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216596009176 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596009177 dimer interface [polypeptide binding]; other site 216596009178 conserved gate region; other site 216596009179 putative PBP binding loops; other site 216596009180 ABC-ATPase subunit interface; other site 216596009181 7 probable transmembrane helices predicted at aa 15-37, 46-68, 179-201, 208-230,250-272, 293-315 and 352-371 216596009182 Pfam match to entry PF00528.10 BPD_transp_1 216596009183 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 216596009184 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 216596009185 active site 216596009186 catalytic site [active] 216596009187 Pfam match to entry PF00128.11 Alpha-amylase 216596009188 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 216596009189 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 216596009190 Walker A/P-loop; other site 216596009191 ATP binding site [chemical binding]; other site 216596009192 Q-loop/lid; other site 216596009193 ABC transporter signature motif; other site 216596009194 Walker B; other site 216596009195 D-loop; other site 216596009196 H-loop/switch region; other site 216596009197 TOBE domain; Region: TOBE; pfam03459 216596009198 TOBE domain; Region: TOBE_2; pfam08402 216596009199 Pfam match to entry PF00005.11 ABC_tran 216596009200 Pfam match to entry PF03459.4 TOBE 216596009201 phosphogluconate dehydratase; Validated; Region: PRK09054 216596009202 6-phosphogluconate dehydratase; Region: edd; TIGR01196 216596009203 Pfam match to entry PF00920.9 ILVD_EDD 216596009204 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 216596009205 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 216596009206 putative active site [active] 216596009207 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 216596009208 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 216596009209 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 216596009210 Pfam match to entry PF02781.4 G6PD_C 216596009211 Pfam match to entry PF00479.8 G6PD_N 216596009212 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 216596009213 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 216596009214 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 216596009215 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 216596009216 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 216596009217 Pfam match to entry PF00120.9 Gln-synt_C 216596009218 Pfam match to entry PF03951.4 Gln-synt_N 216596009219 Predicted flavoproteins [General function prediction only]; Region: COG2081 216596009220 hydroxyglutarate oxidase; Provisional; Region: PRK11728 216596009221 Pfam match to entry PF03486.3 HI0933_like 216596009222 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 216596009223 dimerization interface [polypeptide binding]; other site 216596009224 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216596009225 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 216596009226 dimer interface [polypeptide binding]; other site 216596009227 putative CheW interface [polypeptide binding]; other site 216596009228 1 probable transmembrane helix predicted at aa 16-38 216596009229 Pfam match to entry PF00672.10 HAMP 216596009230 Pfam match to entry PF00015.9 MCPsignal 216596009231 HAMP domain; Region: HAMP; pfam00672 216596009232 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 216596009233 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 216596009234 dimer interface [polypeptide binding]; other site 216596009235 putative CheW interface [polypeptide binding]; other site 216596009236 3 probable transmembrane helices predicted at aa 13-35, 160-182 and 195-217 216596009237 Pfam match to entry PF00672.10 HAMP 216596009238 Pfam match to entry PF00015.9 MCPsignal 216596009239 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596009240 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596009241 Pfam match to entry PF00126.10 HTH_1 216596009242 isocitrate lyase; Provisional; Region: PRK15063 216596009243 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 216596009244 tetramer interface [polypeptide binding]; other site 216596009245 active site 216596009246 Mg2+/Mn2+ binding site [ion binding]; other site 216596009247 Pfam match to entry PF00463.8 ICL 216596009248 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 216596009249 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216596009250 non-specific DNA binding site [nucleotide binding]; other site 216596009251 salt bridge; other site 216596009252 sequence-specific DNA binding site [nucleotide binding]; other site 216596009253 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 216596009254 Domain of unknown function (DUF955); Region: DUF955; pfam06114 216596009255 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 216596009256 Pfam match to entry PF01381.9 HTH_3 216596009257 Pfam match to entry PF06114.2 DUF955 216596009258 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 216596009259 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 216596009260 Pfam match to entry PF01547.11 SBP_bac_1 216596009261 1 probable transmembrane helix predicted at aa 5-24 216596009262 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 216596009263 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 216596009264 Walker A/P-loop; other site 216596009265 ATP binding site [chemical binding]; other site 216596009266 Q-loop/lid; other site 216596009267 ABC transporter signature motif; other site 216596009268 Walker B; other site 216596009269 D-loop; other site 216596009270 H-loop/switch region; other site 216596009271 TOBE domain; Region: TOBE_2; pfam08402 216596009272 Pfam match to entry PF00005.11 ABC_tran 216596009273 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 216596009274 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596009275 dimer interface [polypeptide binding]; other site 216596009276 conserved gate region; other site 216596009277 putative PBP binding loops; other site 216596009278 ABC-ATPase subunit interface; other site 216596009279 6 probable transmembrane helices predicted at aa 13-35, 86-108, 121-143, 171-193,214-236 and 270-292 216596009280 Pfam match to entry PF00528.10 BPD_transp_1 216596009281 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 216596009282 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596009283 dimer interface [polypeptide binding]; other site 216596009284 conserved gate region; other site 216596009285 putative PBP binding loops; other site 216596009286 ABC-ATPase subunit interface; other site 216596009287 6 probable transmembrane helices predicted at aa 7-29, 65-87, 100-122, 132-154,175-197 and 231-253 216596009288 Pfam match to entry PF00528.10 BPD_transp_1 216596009289 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 216596009290 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 216596009291 Pfam match to entry PF05170.2 AsmA 216596009292 1 probable transmembrane helix predicted at aa 21-43 216596009293 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 216596009294 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 216596009295 acyl-activating enzyme (AAE) consensus motif; other site 216596009296 putative AMP binding site [chemical binding]; other site 216596009297 putative active site [active] 216596009298 putative CoA binding site [chemical binding]; other site 216596009299 Pfam match to entry PF00501.11 AMP-binding 216596009300 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 216596009301 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216596009302 putative active site [active] 216596009303 heme pocket [chemical binding]; other site 216596009304 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216596009305 dimer interface [polypeptide binding]; other site 216596009306 phosphorylation site [posttranslational modification] 216596009307 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596009308 ATP binding site [chemical binding]; other site 216596009309 Mg2+ binding site [ion binding]; other site 216596009310 G-X-G motif; other site 216596009311 Pfam match to entry PF02518.9 HATPase_c 216596009312 Pfam match to entry PF00512.10 HisKA 216596009313 Pfam match to entry PF00989.11 PAS 216596009314 Phasin protein; Region: Phasin_2; cl11491 216596009315 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 216596009316 active site 216596009317 NTP binding site [chemical binding]; other site 216596009318 metal binding triad [ion binding]; metal-binding site 216596009319 antibiotic binding site [chemical binding]; other site 216596009320 Higher Eukarytoes and Prokaryotes Nucleotide-binding domain; Region: HEPN; smart00748 216596009321 Pfam match to entry PF01909.9 NTP_transf_2 216596009322 Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768 216596009323 MobA/MobL family; Region: MobA_MobL; pfam03389 216596009324 AAA domain; Region: AAA_30; pfam13604 216596009325 Family description; Region: UvrD_C_2; pfam13538 216596009326 Pfam match to entry PF03389.3 MobA_MobL 216596009327 Domain of unknown function (DUF4174); Region: DUF4174; pfam13778 216596009328 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596009329 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596009330 LysR substrate binding domain; Region: LysR_substrate; pfam03466 216596009331 dimerization interface [polypeptide binding]; other site 216596009332 Pfam match to entry PF03466.5 LysR_substrate 216596009333 Pfam match to entry PF00126.10 HTH_1 216596009334 Uncharacterized conserved protein [Function unknown]; Region: COG1359 216596009335 Pfam match to entry PF03992.3 ABM 216596009336 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 216596009337 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 216596009338 tetrameric interface [polypeptide binding]; other site 216596009339 NAD binding site [chemical binding]; other site 216596009340 catalytic residues [active] 216596009341 Pfam match to entry PF00171.9 Aldedh 216596009342 iron-responsive transcriptional regulator; Reviewed; Region: rirA; PRK11920 216596009343 Rrf2 family protein; Region: rrf2_super; TIGR00738 216596009344 Pfam match to entry PF02082.5 Rrf2 216596009345 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 216596009346 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 216596009347 peptide binding site [polypeptide binding]; other site 216596009348 Pfam match to entry PF00496.8 SBP_bac_5 216596009349 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 216596009350 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596009351 dimer interface [polypeptide binding]; other site 216596009352 conserved gate region; other site 216596009353 putative PBP binding loops; other site 216596009354 ABC-ATPase subunit interface; other site 216596009355 6 probable transmembrane helices predicted at aa 5-27, 100-122, 135-157, 195-217,264-286 and 306-328 216596009356 Pfam match to entry PF00528.10 BPD_transp_1 216596009357 dipeptide transporter; Provisional; Region: PRK10913 216596009358 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 216596009359 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596009360 dimer interface [polypeptide binding]; other site 216596009361 conserved gate region; other site 216596009362 putative PBP binding loops; other site 216596009363 ABC-ATPase subunit interface; other site 216596009364 5 probable transmembrane helices predicted at aa 26-48, 99-121, 142-164, 214-236 and 256-278 216596009365 Pfam match to entry PF00528.10 BPD_transp_1 216596009366 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 216596009367 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596009368 Walker A/P-loop; other site 216596009369 ATP binding site [chemical binding]; other site 216596009370 Q-loop/lid; other site 216596009371 ABC transporter signature motif; other site 216596009372 Walker B; other site 216596009373 D-loop; other site 216596009374 H-loop/switch region; other site 216596009375 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 216596009376 Pfam match to entry PF00005.11 ABC_tran 216596009377 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 216596009378 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596009379 Walker A/P-loop; other site 216596009380 ATP binding site [chemical binding]; other site 216596009381 Q-loop/lid; other site 216596009382 ABC transporter signature motif; other site 216596009383 Walker B; other site 216596009384 D-loop; other site 216596009385 H-loop/switch region; other site 216596009386 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 216596009387 Pfam match to entry PF00005.11 ABC_tran 216596009388 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 216596009389 AAA domain; Region: AAA_33; pfam13671 216596009390 ATP-binding site [chemical binding]; other site 216596009391 Gluconate-6-phosphate binding site [chemical binding]; other site 216596009392 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 216596009393 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 216596009394 Phospholipid methyltransferase; Region: PEMT; cl17370 216596009395 Pfam match to entry PF04140.3 ICMT 216596009396 2 probable transmembrane helices predicted at aa 66-85 and 119-141 216596009397 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 216596009398 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 216596009399 malonyl-CoA binding site [chemical binding]; other site 216596009400 dimer interface [polypeptide binding]; other site 216596009401 active site 216596009402 product binding site; other site 216596009403 Pfam match to entry PF02797.4 Chal_sti_synt_C 216596009404 Pfam match to entry PF00195.8 Chal_sti_synt_N 216596009405 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216596009406 TPR motif; other site 216596009407 Tetratricopeptide repeat; Region: TPR_16; pfam13432 216596009408 binding surface 216596009409 1 probable transmembrane helix predicted at aa 7-29 216596009410 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 216596009411 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216596009412 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 216596009413 DNA binding residues [nucleotide binding] 216596009414 Pfam match to entry PF04542.2 Sigma70_r2 216596009415 Pfam match to entry PF04545.3 Sigma70_r4 216596009416 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 216596009417 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 216596009418 active site 216596009419 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 216596009420 Pfam match to entry PF00353.8 HemolysinCabind 216596009421 Pfam match to entry PF00353.8 HemolysinCabind 216596009422 Pfam match to entry PF00353.8 HemolysinCabind 216596009423 Pfam match to entry PF00353.8 HemolysinCabind 216596009424 Pfam match to entry PF00353.8 HemolysinCabind 216596009425 Pfam match to entry PF00353.8 HemolysinCabind 216596009426 Pfam match to entry PF00353.8 HemolysinCabind 216596009427 Pfam match to entry PF00353.8 HemolysinCabind 216596009428 Pfam match to entry PF00353.8 HemolysinCabind 216596009429 Pfam match to entry PF00353.8 HemolysinCabind 216596009430 Pfam match to entry PF00353.8 HemolysinCabind 216596009431 Pfam match to entry PF00353.8 HemolysinCabind 216596009432 Pfam match to entry PF00353.8 HemolysinCabind 216596009433 Pfam match to entry PF00353.8 HemolysinCabind 216596009434 Pfam match to entry PF00353.8 HemolysinCabind 216596009435 Pfam match to entry PF00353.8 HemolysinCabind 216596009436 Pfam match to entry PF00353.8 HemolysinCabind 216596009437 Pfam match to entry PF00353.8 HemolysinCabind 216596009438 Pfam match to entry PF00353.8 HemolysinCabind 216596009439 Pfam match to entry PF00353.8 HemolysinCabind 216596009440 Pfam match to entry PF00353.8 HemolysinCabind 216596009441 Pfam match to entry PF00353.8 HemolysinCabind 216596009442 Pfam match to entry PF00353.8 HemolysinCabind 216596009443 Pfam match to entry PF00353.8 HemolysinCabind 216596009444 Pfam match to entry PF00353.8 HemolysinCabind 216596009445 Pfam match to entry PF00353.8 HemolysinCabind 216596009446 Pfam match to entry PF00353.8 HemolysinCabind 216596009447 Pfam match to entry PF00353.8 HemolysinCabind 216596009448 Pfam match to entry PF00353.8 HemolysinCabind 216596009449 submitted without /pseudo; Similar to codons 500 to 610 of Leptospira interrogans outermembrane protein. UniProt:Q8F5C4 (EMBL:AE011352) (706 aa); similarity:fasta; with=UniProt:Q8F5C4 (EMBL:AE011352); Leptospira interrogans.; outermembrane protein.; length=706; id 43.860; 114 aa overlap; query 17-129; subject 502-610 216596009450 Pfam match to entry PF01344.10 Kelch_1 216596009451 putative transposase OrfB; Reviewed; Region: PHA02517 216596009452 HTH-like domain; Region: HTH_21; pfam13276 216596009453 Integrase core domain; Region: rve; pfam00665 216596009454 Integrase core domain; Region: rve_3; pfam13683 216596009455 Pfam match to entry PF00665.10 rve 216596009456 Transposase; Region: HTH_Tnp_1; pfam01527 216596009457 Pfam match to entry PF01527.7 Transposase_8 216596009458 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 216596009459 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 216596009460 inhibitor-cofactor binding pocket; inhibition site 216596009461 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596009462 catalytic residue [active] 216596009463 Pfam match to entry PF01041.7 DegT_DnrJ_EryC1 216596009464 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 216596009465 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 216596009466 substrate binding site; other site 216596009467 tetramer interface; other site 216596009468 Pfam match to entry PF00483.9 NTP_transferase 216596009469 Methyltransferase domain; Region: Methyltransf_23; pfam13489 216596009470 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596009471 S-adenosylmethionine binding site [chemical binding]; other site 216596009472 Predicted membrane protein [Function unknown]; Region: COG2246 216596009473 GtrA-like protein; Region: GtrA; pfam04138 216596009474 Pfam match to entry PF04138.2 GtrA 216596009475 4 probable transmembrane helices predicted at aa 36-58, 63-85, 94-116 and 126-148 216596009476 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 216596009477 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 216596009478 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 216596009479 putative trimer interface [polypeptide binding]; other site 216596009480 putative CoA binding site [chemical binding]; other site 216596009481 Pfam match to entry PF00132.9 Hexapep 216596009482 Pfam match to entry PF00132.9 Hexapep 216596009483 Pfam match to entry PF00132.9 Hexapep 216596009484 Pfam match to entry PF00132.9 Hexapep 216596009485 Pfam match to entry PF00132.9 Hexapep 216596009486 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596009487 S-adenosylmethionine binding site [chemical binding]; other site 216596009488 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 216596009489 Ligand binding site; other site 216596009490 Putative Catalytic site; other site 216596009491 DXD motif; other site 216596009492 2 probable transmembrane helices predicted at aa 229-251 and 266-288 216596009493 Pfam match to entry PF00535.10 Glycos_transf_2 216596009494 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 216596009495 Pfam match to entry PF05721.2 PhyH 216596009496 Methyltransferase domain; Region: Methyltransf_23; pfam13489 216596009497 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596009498 S-adenosylmethionine binding site [chemical binding]; other site 216596009499 WbqC-like protein family; Region: WbqC; pfam08889 216596009500 Protein of unknown function, DUF393; Region: DUF393; pfam04134 216596009501 9 probable transmembrane helices predicted at aa 25-47, 52-71, 143-165, 180-202,240-262, 298-320, 325-347, 445-467 and 511-533 216596009502 11 probable transmembrane helices predicted at aa 13-35, 88-110, 117-139, 183-205,212-231, 275-292, 299-321, 331-350, 357-379, 389-406 and 413-435 216596009503 Methyltransferase domain; Region: Methyltransf_23; pfam13489 216596009504 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596009505 S-adenosylmethionine binding site [chemical binding]; other site 216596009506 2 probable transmembrane helices predicted at aa 13-35 and 45-67 216596009507 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 216596009508 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 216596009509 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 216596009510 NAD(P) binding site [chemical binding]; other site 216596009511 homodimer interface [polypeptide binding]; other site 216596009512 substrate binding site [chemical binding]; other site 216596009513 active site 216596009514 5 probable transmembrane helices predicted at aa 21-40, 55-77, 84-106, 116-138 and 151-168 216596009515 Pfam match to entry PF02719.4 Polysacc_synt_2 216596009516 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 216596009517 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 216596009518 metal-binding site 216596009519 Pfam match to entry PF00535.10 Glycos_transf_2 216596009520 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 216596009521 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 216596009522 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 216596009523 extended (e) SDRs; Region: SDR_e; cd08946 216596009524 NAD(P) binding site [chemical binding]; other site 216596009525 active site 216596009526 substrate binding site [chemical binding]; other site 216596009527 Pfam match to entry PF01370.8 Epimerase 216596009528 Methyltransferase domain; Region: Methyltransf_23; pfam13489 216596009529 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596009530 S-adenosylmethionine binding site [chemical binding]; other site 216596009531 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 216596009532 putative trimer interface [polypeptide binding]; other site 216596009533 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 216596009534 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 216596009535 trimer interface [polypeptide binding]; other site 216596009536 active site 216596009537 substrate binding site [chemical binding]; other site 216596009538 putative CoA binding site [chemical binding]; other site 216596009539 CoA binding site [chemical binding]; other site 216596009540 Pfam match to entry PF00132.9 Hexapep 216596009541 Pfam match to entry PF00132.9 Hexapep 216596009542 Pfam match to entry PF00132.9 Hexapep 216596009543 Pfam match to entry PF00132.9 Hexapep 216596009544 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 216596009545 11 probable transmembrane helices predicted at aa 5-24, 31-53, 77-99, 120-142,174-196, 208-230, 250-269, 282-304, 357-376, 388-405 and 409-431 216596009546 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 216596009547 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_III; cd01996 216596009548 Ligand Binding Site [chemical binding]; other site 216596009549 imidazole glycerol phosphate synthase subunit HisF; Provisional; Region: PRK01033 216596009550 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 216596009551 substrate binding site [chemical binding]; other site 216596009552 glutamase interaction surface [polypeptide binding]; other site 216596009553 Pfam match to entry PF00977.8 His_biosynth 216596009554 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 216596009555 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 216596009556 putative active site [active] 216596009557 oxyanion strand; other site 216596009558 catalytic triad [active] 216596009559 Pfam match to entry PF00117.10 GATase 216596009560 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 216596009561 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 216596009562 12 probable transmembrane helices predicted at aa 20-42, 52-74, 99-121, 136-158,170-189, 193-212, 309-331, 346-368, 381-403, 407-426,439-461 and 471-493 216596009563 Pfam match to entry PF01943.7 Polysacc_synt 216596009564 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 216596009565 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 216596009566 inhibitor-cofactor binding pocket; inhibition site 216596009567 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596009568 catalytic residue [active] 216596009569 Pfam match to entry PF01041.7 DegT_DnrJ_EryC1 216596009570 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 216596009571 putative trimer interface [polypeptide binding]; other site 216596009572 putative active site [active] 216596009573 putative substrate binding site [chemical binding]; other site 216596009574 putative CoA binding site [chemical binding]; other site 216596009575 Pfam match to entry PF00132.9 Hexapep 216596009576 Pfam match to entry PF00132.9 Hexapep 216596009577 Pfam match to entry PF00132.9 Hexapep 216596009578 Pfam match to entry PF00132.9 Hexapep1 216596009579 Pfam match to entry PF00132.9 Hexapep 216596009580 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 216596009581 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 216596009582 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 216596009583 Pfam match to entry PF02894.4 GFO_IDH_MocA_C 216596009584 Pfam match to entry PF01408.8 GFO_IDH_MocA 216596009585 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 216596009586 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 216596009587 NADP-binding site; other site 216596009588 homotetramer interface [polypeptide binding]; other site 216596009589 substrate binding site [chemical binding]; other site 216596009590 homodimer interface [polypeptide binding]; other site 216596009591 active site 216596009592 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 216596009593 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 216596009594 NADP binding site [chemical binding]; other site 216596009595 active site 216596009596 putative substrate binding site [chemical binding]; other site 216596009597 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 216596009598 Transposase; Region: HTH_Tnp_1; pfam01527 216596009599 Pfam match to entry PF01527.7 Transposase_8 216596009600 1 probable transmembrane helix predicted at aa 42-64 216596009601 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 216596009602 Catalytic site; other site 216596009603 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 216596009604 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 216596009605 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 216596009606 DNA binding site [nucleotide binding] 216596009607 Pfam match to entry PF01068.9 DNA_ligase_A_M 216596009608 Pfam match to entry PF04679.4 DNA_ligase_A_C 216596009609 1 probable transmembrane helix predicted at aa 13-35 216596009610 2 probable transmembrane helices predicted at aa 2-19 and 23-42 216596009611 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 216596009612 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 216596009613 catalytic residues [active] 216596009614 catalytic nucleophile [active] 216596009615 Recombinase; Region: Recombinase; pfam07508 216596009616 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 216596009617 Pfam match to entry PF00239.10 Resolvase 216596009618 Pfam match to entry PF07508.1 Recombinase 216596009619 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 216596009620 Pfam match to entry PF01402.8 HTH_4 216596009621 exopolyphosphatase; Region: exo_poly_only; TIGR03706 216596009622 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 216596009623 Pfam match to entry PF02541.4 Ppx-GppA 216596009624 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 216596009625 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596009626 S-adenosylmethionine binding site [chemical binding]; other site 216596009627 Pfam match to entry PF01728.7 FtsJ 216596009628 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 216596009629 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596009630 putative substrate translocation pore; other site 216596009631 14 probable transmembrane helices predicted at aa 49-71, 81-103, 116-138, 143-163,176-198, 202-224, 237-259, 263-282, 303-325, 330-352,365-387, 397-419, 440-459 and 469-488 216596009632 Pfam match to entry PF00083.9 Sugar_tr 216596009633 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 216596009634 Pfam match to entry PF00753.12 Lactamase_B 216596009635 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 216596009636 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 216596009637 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 216596009638 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 216596009639 active site 216596009640 Pfam match to entry PF00478.11 IMPDH 216596009641 Pfam match to entry PF00571.13 CBS 216596009642 Pfam match to entry PF00571.13 CBS 216596009643 SGT1 protein; Region: SGT1; pfam07093 216596009644 4 probable transmembrane helices predicted at aa 7-29, 82-104, 117-139 and 154-176 216596009645 MAPEG family; Region: MAPEG; cl09190 216596009646 Pfam match to entry PF06561.1 DUF1123 216596009647 2 probable transmembrane helices predicted at aa 39-61 and 150-172 216596009648 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216596009649 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216596009650 Pfam match to entry PF00440.8 TetR_N 216596009651 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 216596009652 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596009653 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216596009654 dimerization interface [polypeptide binding]; other site 216596009655 Pfam match to entry PF03466.5 LysR_substrate 216596009656 1 probable transmembrane helix predicted at aa 172-194 216596009657 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 216596009658 Pfam match to entry PF06568.1 DUF1127 216596009659 Uncharacterized conserved protein [Function unknown]; Region: COG5403 216596009660 Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572 216596009661 Pfam match to entry PF04107.2 GCS2 216596009662 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 216596009663 RNA methyltransferase, RsmE family; Region: TIGR00046 216596009664 Pfam match to entry PF04452.2 DUF558 216596009665 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 216596009666 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 216596009667 13 probable transmembrane helices predicted at aa 34-56, 61-80, 101-118, 133-155,162-184, 199-221, 234-253, 263-285, 297-319, 349-371,383-405, 410-427 and 469-491 216596009668 Pfam match to entry PF01384.9 PHO4 216596009669 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 216596009670 nudix motif; other site 216596009671 Pfam match to entry PF00293.12 NUDIX 216596009672 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 216596009673 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596009674 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216596009675 dimerization interface [polypeptide binding]; other site 216596009676 Pfam match to entry PF00126.10 HTH_1 216596009677 Pfam match to entry PF03466.5 LysR_substrate 216596009678 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 216596009679 NAD binding site [chemical binding]; other site 216596009680 Pfam match to entry PF05221.5 AdoHcyase 216596009681 Pfam match to entry PF00670.10 AdoHcyase_NAD 216596009682 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 216596009683 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 216596009684 putative NAD(P) binding site [chemical binding]; other site 216596009685 Pfam match to entry PF00107.10 ADH_zinc_N 216596009686 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596009687 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596009688 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 216596009689 dimerization interface [polypeptide binding]; other site 216596009690 Pfam match to entry PF00126.10 HTH_1 216596009691 Pfam match to entry PF03466.5 LysR_substrate 216596009692 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596009693 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596009694 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 216596009695 putative effector binding pocket; other site 216596009696 dimerization interface [polypeptide binding]; other site 216596009697 Pfam match to entry PF03466.5 LysR_substrate 216596009698 Pfam match to entry PF00126.10 HTH_1 216596009699 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 216596009700 FAD binding domain; Region: FAD_binding_4; pfam01565 216596009701 Pfam match to entry PF01565.10 FAD_binding_4 216596009702 Pfam match to entry PF02913.7 FAD-oxidase_C 216596009703 FAD binding domain; Region: FAD_binding_4; pfam01565 216596009704 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 216596009705 Pfam match to entry PF01565.10 FAD_binding_4 216596009706 Pfam match to entry PF02913.7 FAD-oxidase_C 216596009707 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 216596009708 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 216596009709 Cysteine-rich domain; Region: CCG; pfam02754 216596009710 Cysteine-rich domain; Region: CCG; pfam02754 216596009711 Pfam match to entry PF00037.11 Fer4 216596009712 Pfam match to entry PF00037.11 Fer4 216596009713 Pfam match to entry PF02754.4 CCG 216596009714 Pfam match to entry PF02754.4 CCG 216596009715 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 216596009716 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 216596009717 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 216596009718 Pfam match to entry PF03734.4 ErfK_YbiS_YhnG 216596009719 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 216596009720 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 216596009721 Pfam match to entry PF03734.4 ErfK_YbiS_YhnG 216596009722 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 216596009723 Pfam match to entry PF03352.3 Adenine_glyco 216596009724 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 216596009725 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216596009726 motif II; other site 216596009727 Pfam match to entry PF00702.10 Hydrolase 216596009728 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 216596009729 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 216596009730 active site 216596009731 catalytic tetrad [active] 216596009732 Pfam match to entry PF00248.9 Aldo_ket_red 216596009733 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544 216596009734 Pfam match to entry PF03713.3 DUF305 216596009735 no significant database hits 216596009736 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 216596009737 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 216596009738 dimer interface [polypeptide binding]; other site 216596009739 motif 1; other site 216596009740 active site 216596009741 motif 2; other site 216596009742 motif 3; other site 216596009743 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 216596009744 anticodon binding site; other site 216596009745 Pfam match to entry PF00587.10 tRNA-synt_2b 216596009746 Pfam match to entry PF03129.7 HGTP_anticodon 216596009747 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295 216596009748 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 216596009749 motif 1; other site 216596009750 dimer interface [polypeptide binding]; other site 216596009751 active site 216596009752 motif 2; other site 216596009753 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 216596009754 motif 3; other site 216596009755 Pfam match to entry PF00587.10 tRNA-synt_2b 216596009756 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 216596009757 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13583 216596009758 Pfam match to entry PF01634.6 HisG 216596009759 Predicted membrane protein [Function unknown]; Region: COG2259 216596009760 Pfam match to entry PF04173.2 DoxD 216596009761 4 probable transmembrane helices predicted at aa 7-24, 44-66, 71-93 and 116-135 216596009762 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 216596009763 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 216596009764 C-terminal domain interface [polypeptide binding]; other site 216596009765 GSH binding site (G-site) [chemical binding]; other site 216596009766 dimer interface [polypeptide binding]; other site 216596009767 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 216596009768 dimer interface [polypeptide binding]; other site 216596009769 N-terminal domain interface [polypeptide binding]; other site 216596009770 Pfam match to entry PF02798.6 GST_N 216596009771 Pfam match to entry PF00043.11 GST_C 216596009772 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 216596009773 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 216596009774 ring oligomerisation interface [polypeptide binding]; other site 216596009775 ATP/Mg binding site [chemical binding]; other site 216596009776 stacking interactions; other site 216596009777 hinge regions; other site 216596009778 Pfam match to entry PF00118.12 Cpn60_TCP1 216596009779 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 216596009780 oligomerisation interface [polypeptide binding]; other site 216596009781 mobile loop; other site 216596009782 roof hairpin; other site 216596009783 Pfam match to entry PF00166.8 Cpn10 216596009784 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 216596009785 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 216596009786 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 216596009787 Pfam match to entry PF00702.10 Hydrolase 216596009788 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 216596009789 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 216596009790 active site 216596009791 Riboflavin kinase; Region: Flavokinase; smart00904 216596009792 Pfam match to entry PF06574.1 Flavokinase 216596009793 Pfam match to entry PF01687.7 FAD_Synth 216596009794 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 216596009795 oligomeric interface; other site 216596009796 putative active site [active] 216596009797 homodimer interface [polypeptide binding]; other site 216596009798 Pfam match to entry PF01850.8 PIN 216596009799 prevent-host-death family protein; Region: phd_fam; TIGR01552 216596009800 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 216596009801 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 216596009802 active site 216596009803 HIGH motif; other site 216596009804 nucleotide binding site [chemical binding]; other site 216596009805 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 216596009806 active site 216596009807 KMSKS motif; other site 216596009808 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 216596009809 tRNA binding surface [nucleotide binding]; other site 216596009810 anticodon binding site; other site 216596009811 Pfam match to entry PF00133.8 tRNA-synt_1 216596009812 Pfam match to entry PF06827.1 zf-FPG_IleRS 216596009813 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 216596009814 nucleoside/Zn binding site; other site 216596009815 dimer interface [polypeptide binding]; other site 216596009816 catalytic motif [active] 216596009817 Pfam match to entry PF00383.9 dCMP_cyt_deam 216596009818 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 216596009819 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 216596009820 RNA binding surface [nucleotide binding]; other site 216596009821 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 216596009822 active site 216596009823 Pfam match to entry PF01479.9 S4 216596009824 Pfam match to entry PF00849.9 PseudoU_synth_2 216596009825 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 216596009826 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596009827 S-adenosylmethionine binding site [chemical binding]; other site 216596009828 Pfam match to entry PF03602.4 Cons_hypoth95 216596009829 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 216596009830 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 216596009831 nucleophile elbow; other site 216596009832 Pfam match to entry PF01734.8 Patatin 216596009833 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 216596009834 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 216596009835 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 216596009836 5 probable transmembrane helices predicted at aa 28-50, 153-175, 203-225, 372-394 and 414-436 216596009837 Pfam match to entry PF03929.4 PepSY_TM 216596009838 Pfam match to entry PF03413.5 PepSY 216596009839 Pfam match to entry PF03929.4 PepSY_TM 216596009840 Pfam match to entry PF03929.4 PepSY_TM 216596009841 Pfam match to entry PF03413.5 PepSY 216596009842 Pfam match to entry PF03929.4 PepSY_TM 216596009843 1 probable transmembrane helix predicted at aa 13-35 216596009844 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 216596009845 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 216596009846 TrkA-N domain; Region: TrkA_N; pfam02254 216596009847 Pfam match to entry PF02254.5 TrkA_N 216596009848 12 probable transmembrane helices predicted at aa 46-65, 72-91, 96-115, 127-149,154-176, 189-211, 221-243, 263-285, 305-326, 333-355,370-392 and 399-418 216596009849 Pfam match to entry PF00999.9 Na_H_Exchanger 216596009850 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 216596009851 Pfam match to entry PF01523.6 PmbA_TldD 216596009852 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 216596009853 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 216596009854 active site 216596009855 Pfam match to entry PF00459.10 Inositol_P 216596009856 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 216596009857 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 216596009858 Pfam match to entry PF04413.3 Glycos_transf_N 216596009859 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 216596009860 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216596009861 motif II; other site 216596009862 Pfam match to entry PF00702.10 Hydrolase 216596009863 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 216596009864 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 216596009865 Pfam match to entry PF02606.4 LpxK 216596009866 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596009867 DNA-binding site [nucleotide binding]; DNA binding site 216596009868 Transcriptional regulators [Transcription]; Region: FadR; COG2186 216596009869 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596009870 DNA-binding site [nucleotide binding]; DNA binding site 216596009871 FCD domain; Region: FCD; pfam07729 216596009872 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596009873 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216596009874 TM-ABC transporter signature motif; other site 216596009875 9 probable transmembrane helices predicted at aa 35-57, 67-86, 93-112, 117-139,146-168, 183-205, 236-258, 273-295 and 308-330 216596009876 Pfam match to entry PF02653.5 BPD_transp_2 216596009877 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 216596009878 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216596009879 Walker A/P-loop; other site 216596009880 ATP binding site [chemical binding]; other site 216596009881 Q-loop/lid; other site 216596009882 ABC transporter signature motif; other site 216596009883 Walker B; other site 216596009884 D-loop; other site 216596009885 H-loop/switch region; other site 216596009886 Pfam match to entry PF00005.11 ABC_tran 216596009887 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 216596009888 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 216596009889 ligand binding site [chemical binding]; other site 216596009890 Pfam match to entry PF00532.8 Peripla_BP_1 216596009891 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3908 216596009892 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 216596009893 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596009894 ATP binding site [chemical binding]; other site 216596009895 Mg2+ binding site [ion binding]; other site 216596009896 G-X-G motif; other site 216596009897 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 216596009898 ATP binding site [chemical binding]; other site 216596009899 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 216596009900 Pfam match to entry PF01119.7 DNA_mis_repair 216596009901 Pfam match to entry PF02518.9 HATPase_c 216596009902 PAS fold; Region: PAS_7; pfam12860 216596009903 PAS fold; Region: PAS_4; pfam08448 216596009904 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216596009905 putative active site [active] 216596009906 heme pocket [chemical binding]; other site 216596009907 Response regulator receiver domain; Region: Response_reg; pfam00072 216596009908 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596009909 active site 216596009910 phosphorylation site [posttranslational modification] 216596009911 intermolecular recognition site; other site 216596009912 dimerization interface [polypeptide binding]; other site 216596009913 Pfam match to entry PF00989.11 PAS 216596009914 Pfam match to entry PF00072.9 Response_reg 216596009915 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 216596009916 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216596009917 metal binding site [ion binding]; metal-binding site 216596009918 active site 216596009919 I-site; other site 216596009920 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216596009921 Pfam match to entry PF00990.8 GGDEF 216596009922 Pfam match to entry PF00563.9 EAL 216596009923 PRC-barrel domain; Region: PRC; pfam05239 216596009924 Pfam match to entry PF05239.2 PRC 216596009925 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 216596009926 Pfam match to entry PF03758.3 SMP-30 216596009927 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 216596009928 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 216596009929 active site 216596009930 intersubunit interface [polypeptide binding]; other site 216596009931 catalytic residue [active] 216596009932 Pfam match to entry PF01081.7 Aldolase 216596009933 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 216596009934 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 216596009935 Pfam match to entry PF05035.2 DGOK 216596009936 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 216596009937 classical (c) SDRs; Region: SDR_c; cd05233 216596009938 NAD(P) binding site [chemical binding]; other site 216596009939 active site 216596009940 Pfam match to entry PF00106.11 adh_short 216596009941 Transcriptional regulator [Transcription]; Region: IclR; COG1414 216596009942 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 216596009943 Bacterial transcriptional regulator; Region: IclR; pfam01614 216596009944 Pfam match to entry PF01614.6 IclR 216596009945 Autoinducer binding domain; Region: Autoind_bind; pfam03472 216596009946 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216596009947 dimerization interface [polypeptide binding]; other site 216596009948 DNA binding residues [nucleotide binding] 216596009949 Pfam match to entry PF00196.8 GerE 216596009950 Domain of unknown function DUF59; Region: DUF59; pfam01883 216596009951 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 216596009952 Pfam match to entry PF01883.7 DUF59 216596009953 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 216596009954 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 216596009955 Cl binding site [ion binding]; other site 216596009956 oligomer interface [polypeptide binding]; other site 216596009957 Pfam match to entry PF01544.8 CorA 216596009958 2 probable transmembrane helices predicted at aa 274-296 and 306-328 216596009959 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 216596009960 12 probable transmembrane helices predicted at aa 17-39, 59-81, 108-130, 145-164,171-193, 208-230, 250-272, 292-314, 342-364, 369-390,397-419 and 429-447 216596009961 Pfam match to entry PF02705.5 K_trans 216596009962 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 216596009963 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 216596009964 Pfam match to entry PF07486.1 Hydrolase_2 216596009965 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5336 216596009966 2 probable transmembrane helices predicted at aa 50-68 and 72-94 216596009967 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 216596009968 ATP synthase subunit 6 (eukaryotes),also subunit A (prokaryotes); Region: ATP_synt_6_or_A; TIGR01131 216596009969 6 probable transmembrane helices predicted at aa 25-47, 85-107, 112-134, 141-163,190-212 and 219-241 216596009970 Pfam match to entry PF00119.8 ATP-synt_A 216596009971 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 216596009972 Pfam match to entry PF00137.8 ATP-synt_C 216596009973 2 probable transmembrane helices predicted at aa 41-63 and 83-105 216596009974 F0F1 ATP synthase subunit B'; Validated; Region: PRK09174 216596009975 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 216596009976 1 probable transmembrane helix predicted at aa 53-72 216596009977 Pfam match to entry PF00430.8 ATP-synt_B 216596009978 F0F1 ATP synthase subunit B; Validated; Region: PRK09173 216596009979 Pfam match to entry PF00430.8 ATP-synt_B 216596009980 1 probable transmembrane helix predicted at aa 7-24 216596009981 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 216596009982 RNA/DNA hybrid binding site [nucleotide binding]; other site 216596009983 active site 216596009984 Pfam match to entry PF01351.7 RNase_HII 216596009985 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 216596009986 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 216596009987 FeS/SAM binding site; other site 216596009988 Pfam match to entry PF04055.4 Radical_SAM 216596009989 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 216596009990 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 216596009991 1 probable transmembrane helix predicted at aa 7-29 216596009992 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 216596009993 MPT binding site; other site 216596009994 trimer interface [polypeptide binding]; other site 216596009995 Pfam match to entry PF00994.10 MoCF_biosynth 216596009996 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 216596009997 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 216596009998 Pfam match to entry PF00288.10 GHMP_kinases 216596009999 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216596010000 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216596010001 TPR motif; other site 216596010002 binding surface 216596010003 TPR repeat; Region: TPR_11; pfam13414 216596010004 TPR repeat; Region: TPR_11; pfam13414 216596010005 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216596010006 binding surface 216596010007 TPR motif; other site 216596010008 TPR repeat; Region: TPR_11; pfam13414 216596010009 Pfam match to entry PF00515.11 TPR 216596010010 Pfam match to entry PF00515.11 TPR 216596010011 Pfam match to entry PF00515.11 TPR 216596010012 Pfam match to entry PF00515.11 TPR 216596010013 Pfam match to entry PF00515.11 TPR 216596010014 Pfam match to entry PF00515.11 TPR 216596010015 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 216596010016 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 216596010017 substrate binding pocket [chemical binding]; other site 216596010018 chain length determination region; other site 216596010019 substrate-Mg2+ binding site; other site 216596010020 catalytic residues [active] 216596010021 aspartate-rich region 1; other site 216596010022 active site lid residues [active] 216596010023 aspartate-rich region 2; other site 216596010024 Pfam match to entry PF00348.7 polyprenyl_synt 216596010025 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 216596010026 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 216596010027 Methyltransferase domain; Region: Methyltransf_26; pfam13659 216596010028 manganese transport protein MntH; Reviewed; Region: PRK00701 216596010029 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 216596010030 11 probable transmembrane helices predicted at aa 36-55, 70-92, 113-135, 145-167,174-196, 220-239, 269-291, 306-328, 358-375, 385-407 and 420-437 216596010031 Pfam match to entry PF01566.8 Nramp 216596010032 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 216596010033 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 216596010034 tandem repeat interface [polypeptide binding]; other site 216596010035 oligomer interface [polypeptide binding]; other site 216596010036 active site residues [active] 216596010037 Pfam match to entry PF01343.8 Peptidase_S49 216596010038 1 probable transmembrane helix predicted at aa 4-23 216596010039 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 216596010040 dimer interface [polypeptide binding]; other site 216596010041 motif 1; other site 216596010042 active site 216596010043 motif 2; other site 216596010044 motif 3; other site 216596010045 Pfam match to entry PF02091.5 tRNA_synt_2e 216596010046 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 216596010047 Pfam match to entry PF04011.2 LemA 216596010048 1 probable transmembrane helix predicted at aa 4-23 216596010049 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 216596010050 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 216596010051 hinge; other site 216596010052 active site 216596010053 Pfam match to entry PF00275.8 EPSP_synthase 216596010054 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 216596010055 6 probable transmembrane helices predicted at aa 5-27, 239-258, 388-410, 415-437,450-472 and 487-506 216596010056 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 216596010057 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 216596010058 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 216596010059 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 216596010060 Pfam match to entry PF02844.4 GARS_N 216596010061 Pfam match to entry PF02842.4 GARS_B 216596010062 Pfam match to entry PF01071.8 GARS_A 216596010063 Pfam match to entry PF02843.5 GARS_C 216596010064 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 216596010065 HAMP domain; Region: HAMP; pfam00672 216596010066 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216596010067 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 216596010068 dimer interface [polypeptide binding]; other site 216596010069 putative CheW interface [polypeptide binding]; other site 216596010070 2 probable transmembrane helices predicted at aa 10-32 and 187-209 216596010071 Pfam match to entry PF00672.10 HAMP 216596010072 Pfam match to entry PF00015.9 MCPsignal 216596010073 Uncharacterized conserved protein [Function unknown]; Region: COG1683 216596010074 Pfam match to entry PF04463.2 DUF523 216596010075 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 216596010076 Pfam match to entry PF05746.3 tRNA-synt_1d_C 216596010077 Pfam match to entry PF02092.6 tRNA_synt_2f 216596010078 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 216596010079 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 216596010080 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 216596010081 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 216596010082 RNA binding site [nucleotide binding]; other site 216596010083 Pfam match to entry PF00575.9 S1 216596010084 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 216596010085 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596010086 S-adenosylmethionine binding site [chemical binding]; other site 216596010087 Pfam match to entry PF02353.6 CMAS 216596010088 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 216596010089 catalytic core [active] 216596010090 Pfam match to entry PF00300.9 PGAM 216596010091 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 216596010092 Pfam match to entry PF06629.1 MipA 216596010093 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878 216596010094 UbiA prenyltransferase family; Region: UbiA; pfam01040 216596010095 8 probable transmembrane helices predicted at aa 41-63, 68-90, 121-138, 143-162,182-204, 241-260, 264-286 and 299-318 216596010096 Pfam match to entry PF01040.7 UbiA 216596010097 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 216596010098 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 216596010099 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 216596010100 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 216596010101 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 216596010102 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 216596010103 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 216596010104 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 216596010105 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 216596010106 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 216596010107 Pfam match to entry PF06748.1 DUF1217 216596010108 Pfam match to entry PF06748.1 DUF1217 216596010109 Pfam match to entry PF06748.1 DUF1217 216596010110 Pfam match to entry PF06748.1 DUF1217 216596010111 Pfam match to entry PF06748.1 DUF1217 216596010112 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 216596010113 FAD binding domain; Region: FAD_binding_4; pfam01565 216596010114 Pfam match to entry PF02913.7 FAD-oxidase_C 216596010115 Pfam match to entry PF01565.10 FAD_binding_4 216596010116 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 216596010117 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 216596010118 Pfam match to entry PF03481.3 SUA5 216596010119 Pfam match to entry PF01300.7 Sua5_yciO_yrdC 216596010120 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 216596010121 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 216596010122 [2Fe-2S] cluster binding site [ion binding]; other site 216596010123 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 216596010124 putative alpha subunit interface [polypeptide binding]; other site 216596010125 putative active site [active] 216596010126 putative substrate binding site [chemical binding]; other site 216596010127 Fe binding site [ion binding]; other site 216596010128 Pfam match to entry PF00355.13 Rieske 216596010129 BA14K-like protein; Region: BA14K; pfam07886 216596010130 1 probable transmembrane helix predicted at aa 90-112 216596010131 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 216596010132 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 216596010133 Cl binding site [ion binding]; other site 216596010134 oligomer interface [polypeptide binding]; other site 216596010135 Pfam match to entry PF01544.8 CorA 216596010136 2 probable transmembrane helices predicted at aa 298-320 and 335-352 216596010137 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216596010138 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216596010139 active site 216596010140 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 216596010141 Pfam match to entry PF02770.6 Acyl-CoA_dh_M 216596010142 Pfam match to entry PF00441.11 Acyl-CoA_dh 216596010143 enoyl-CoA hydratase; Provisional; Region: PRK06688 216596010144 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216596010145 substrate binding site [chemical binding]; other site 216596010146 oxyanion hole (OAH) forming residues; other site 216596010147 trimer interface [polypeptide binding]; other site 216596010148 Pfam match to entry PF00378.8 ECH 216596010149 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 216596010150 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 216596010151 Pfam match to entry PF00753.12 Lactamase_B 216596010152 Predicted transcriptional regulators [Transcription]; Region: COG1733 216596010153 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 216596010154 Pfam match to entry PF01638.6 DUF24 216596010155 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 216596010156 TRAM domain; Region: TRAM; cl01282 216596010157 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596010158 S-adenosylmethionine binding site [chemical binding]; other site 216596010159 Pfam match to entry PF05958.1 tRNA_U5-meth_tr 216596010160 Pfam match to entry PF01938.8 TRAM 216596010161 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 216596010162 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 216596010163 RNA binding surface [nucleotide binding]; other site 216596010164 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596010165 S-adenosylmethionine binding site [chemical binding]; other site 216596010166 Pfam match to entry PF01728.7 FtsJ 216596010167 Pfam match to entry PF01479.9 S4 216596010168 Domain of unknown function (DUF4424); Region: DUF4424; pfam14415 216596010169 CHASE3 domain; Region: CHASE3; cl05000 216596010170 HAMP domain; Region: HAMP; pfam00672 216596010171 dimerization interface [polypeptide binding]; other site 216596010172 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216596010173 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 216596010174 dimer interface [polypeptide binding]; other site 216596010175 putative CheW interface [polypeptide binding]; other site 216596010176 2 probable transmembrane helices predicted at aa 49-68 and 228-247 216596010177 Pfam match to entry PF05227.2 CHASE3 216596010178 Pfam match to entry PF00672.10 HAMP 216596010179 Pfam match to entry PF00015.9 MCPsignal 216596010180 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 216596010181 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 216596010182 TPP-binding site; other site 216596010183 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 216596010184 PYR/PP interface [polypeptide binding]; other site 216596010185 dimer interface [polypeptide binding]; other site 216596010186 TPP binding site [chemical binding]; other site 216596010187 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 216596010188 Pfam match to entry PF02780.6 Transketolase_C 216596010189 Pfam match to entry PF02779.8 Transket_pyr 216596010190 Pirin-related protein [General function prediction only]; Region: COG1741 216596010191 Pirin; Region: Pirin; pfam02678 216596010192 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 216596010193 Pfam match to entry PF05726.1 Pirin_C 216596010194 Pfam match to entry PF02678.4 Pirin 216596010195 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 216596010196 classical (c) SDRs; Region: SDR_c; cd05233 216596010197 NAD(P) binding site [chemical binding]; other site 216596010198 active site 216596010199 Pfam match to entry PF00106.11 adh_short 216596010200 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 216596010201 Pfam match to entry PF02609.4 Exonuc_VII_S 216596010202 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 216596010203 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 216596010204 putative active site [active] 216596010205 Zn binding site [ion binding]; other site 216596010206 Pfam match to entry PF00850.9 Hist_deacetyl 216596010207 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 216596010208 active site 2 [active] 216596010209 active site 1 [active] 216596010210 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 216596010211 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 216596010212 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 216596010213 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 216596010214 active site 216596010215 Pfam match to entry PF00557.8 Peptidase_M24 216596010216 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 216596010217 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596010218 dimer interface [polypeptide binding]; other site 216596010219 conserved gate region; other site 216596010220 putative PBP binding loops; other site 216596010221 ABC-ATPase subunit interface; other site 216596010222 Pfam match to entry PF00528.10 BPD_transp_1 216596010223 6 probable transmembrane helices predicted at aa 17-39, 72-94, 115-137, 147-169,190-212 and 241-263 216596010224 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 216596010225 Pfam match to entry PF00528.10 BPD_transp_1 216596010226 6 probable transmembrane helices predicted at aa 7-29, 63-85, 92-114, 143-165,186-208 and 244-266 216596010227 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 216596010228 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 216596010229 1 probable transmembrane helix predicted at aa 13-35 216596010230 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 216596010231 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216596010232 Walker A/P-loop; other site 216596010233 ATP binding site [chemical binding]; other site 216596010234 Q-loop/lid; other site 216596010235 ABC transporter signature motif; other site 216596010236 Walker B; other site 216596010237 D-loop; other site 216596010238 H-loop/switch region; other site 216596010239 TOBE domain; Region: TOBE_2; pfam08402 216596010240 Pfam match to entry PF00005.11 ABC_tran 216596010241 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 216596010242 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 216596010243 substrate binding pocket [chemical binding]; other site 216596010244 membrane-bound complex binding site; other site 216596010245 hinge residues; other site 216596010246 1 probable transmembrane helix predicted at aa 21-43 216596010247 Pfam match to entry PF00497.8 SBP_bac_3 216596010248 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 216596010249 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596010250 dimer interface [polypeptide binding]; other site 216596010251 conserved gate region; other site 216596010252 putative PBP binding loops; other site 216596010253 ABC-ATPase subunit interface; other site 216596010254 4 probable transmembrane helices predicted at aa 20-42, 63-92, 107-129 and 243-265 216596010255 Pfam match to entry PF00528.10 BPD_transp_1 216596010256 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 216596010257 Transcriptional regulators [Transcription]; Region: GntR; COG1802 216596010258 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596010259 DNA-binding site [nucleotide binding]; DNA binding site 216596010260 FCD domain; Region: FCD; pfam07729 216596010261 Pfam match to entry PF00392.9 GntR 216596010262 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596010263 Transcriptional regulators [Transcription]; Region: GntR; COG1802 216596010264 DNA-binding site [nucleotide binding]; DNA binding site 216596010265 FCD domain; Region: FCD; pfam07729 216596010266 Pfam match to entry PF00392.9 GntR 216596010267 Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292 216596010268 Pfam match to entry PF05292.1 MCD 216596010269 malonyl-CoA synthase; Validated; Region: PRK07514 216596010270 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 216596010271 acyl-activating enzyme (AAE) consensus motif; other site 216596010272 active site 216596010273 AMP binding site [chemical binding]; other site 216596010274 CoA binding site [chemical binding]; other site 216596010275 Pfam match to entry PF00501.11 AMP-binding 216596010276 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 216596010277 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 216596010278 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 216596010279 Pfam match to entry PF07158.1 MatC_N 216596010280 10 probable transmembrane helices predicted at aa 15-37, 50-72, 92-126, 138-160,175-197, 265-287, 302-320, 333-355, 365-387 and 423-445 216596010281 pyruvate kinase, pseudogene; Similar to Agrobacterium vitis (Rhizobium vitis) ttue pyruvate kinase (ec 2.7.1.40) (pk). pyruvate kinase (ec 2.7.1.40) (pk). UniProt:KPY3_AGRVI (EMBL:AV32375) (474 aa); similarity:fasta; with=UniProt:KPY3_AGRVI (EMBL:AV32375); Agrobacterium vitis (Rhizobium vitis).; ttuE; Pyruvate kinase (EC 2.7.1.40) (PK). Pyruvate kinase (EC 2.7.1.40) (PK).; length=474; id 62.376; 101 aa overlap; query 1-101; subject 3-103 216596010282 Pfam match to entry PF00224.9 PK 216596010283 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 216596010284 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 216596010285 MOFRL family; Region: MOFRL; pfam05161 216596010286 Pfam match to entry PF05161.2 MOFRL 216596010287 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 216596010288 tartrate dehydrogenase; Region: TTC; TIGR02089 216596010289 Pfam match to entry PF00180.7 Iso_dh 216596010290 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596010291 D-galactonate transporter; Region: 2A0114; TIGR00893 216596010292 putative substrate translocation pore; other site 216596010293 Pfam match to entry PF00083.9 Sugar_tr 216596010294 11 probable transmembrane helices predicted at aa 47-69, 84-106, 113-132, 142-164,171-193, 206-228, 273-295, 305-327, 340-374, 389-411 and 424-446 216596010295 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 216596010296 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596010297 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 216596010298 dimerization interface [polypeptide binding]; other site 216596010299 substrate binding pocket [chemical binding]; other site 216596010300 Pfam match to entry PF00126.10 HTH_1 216596010301 Pfam match to entry PF03466.5 LysR_substrate 216596010302 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 216596010303 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 216596010304 active site 216596010305 HIGH motif; other site 216596010306 KMSKS motif; other site 216596010307 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 216596010308 anticodon binding site; other site 216596010309 tRNA binding surface [nucleotide binding]; other site 216596010310 Pfam match to entry PF00133.8 tRNA-synt_1 216596010311 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216596010312 PAS domain; Region: PAS_9; pfam13426 216596010313 putative active site [active] 216596010314 heme pocket [chemical binding]; other site 216596010315 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216596010316 dimer interface [polypeptide binding]; other site 216596010317 phosphorylation site [posttranslational modification] 216596010318 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 216596010319 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596010320 ATP binding site [chemical binding]; other site 216596010321 Mg2+ binding site [ion binding]; other site 216596010322 G-X-G motif; other site 216596010323 Pfam match to entry PF02518.9 HATPase_c 216596010324 Pfam match to entry PF00512.10 HisKA 216596010325 Pfam match to entry PF00989.11 PAS 216596010326 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 216596010327 Pfam match to entry PF00561.8 Abhydrolase_1 216596010328 GXWXG protein; Region: GXWXG; pfam14231 216596010329 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 216596010330 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 216596010331 Pfam match to entry PF02632.4 BioY 216596010332 5 probable transmembrane helices predicted at aa 12-34, 54-76, 81-103, 123-145 and 158-180 216596010333 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 216596010334 Pfam match to entry PF02361.5 CbiQ 216596010335 3 probable transmembrane helices predicted at aa 21-50, 65-82 and 89-111 216596010336 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 216596010337 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 216596010338 Walker A/P-loop; other site 216596010339 ATP binding site [chemical binding]; other site 216596010340 Q-loop/lid; other site 216596010341 ABC transporter signature motif; other site 216596010342 Walker B; other site 216596010343 D-loop; other site 216596010344 H-loop/switch region; other site 216596010345 Pfam match to entry PF00005.11 ABC_tran 216596010346 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 216596010347 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 216596010348 Pfam match to entry PF06224.2 DUF1006 216596010349 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09314 216596010350 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 216596010351 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 216596010352 dimerization interface [polypeptide binding]; other site 216596010353 active site 216596010354 Pfam match to entry PF00925.8 GTP_cyclohydro2 216596010355 Pfam match to entry PF00926.7 DHBP_synthase 216596010356 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 216596010357 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 216596010358 Tetramer interface [polypeptide binding]; other site 216596010359 active site 216596010360 FMN-binding site [chemical binding]; other site 216596010361 Pfam match to entry PF01264.9 Chorismate_synt 216596010362 CHASE domain; Region: CHASE; cl01369 216596010363 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 216596010364 PAS fold; Region: PAS_3; pfam08447 216596010365 putative active site [active] 216596010366 heme pocket [chemical binding]; other site 216596010367 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 216596010368 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216596010369 metal binding site [ion binding]; metal-binding site 216596010370 active site 216596010371 I-site; other site 216596010372 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216596010373 Pfam match to entry PF00563.9 EAL 216596010374 Pfam match to entry PF00990.8 GGDEF 216596010375 Pfam match to entry PF00785.11 PAC 216596010376 Pfam match to entry PF00785.11 PAC 216596010377 2 probable transmembrane helices predicted at aa 4-26 and 273-295 216596010378 Protein of unknown function (DUF1344); Region: DUF1344; pfam07076 216596010379 1 probable transmembrane helix predicted at aa 13-30 216596010380 Pfam match to entry PF07076.1 DUF1344 216596010381 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 216596010382 catalytic core [active] 216596010383 Pfam match to entry PF00300.9 PGAM 216596010384 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 216596010385 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 216596010386 NAD binding site [chemical binding]; other site 216596010387 homotetramer interface [polypeptide binding]; other site 216596010388 homodimer interface [polypeptide binding]; other site 216596010389 substrate binding site [chemical binding]; other site 216596010390 active site 216596010391 Pfam match to entry PF00106.11 adh_short 216596010392 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 216596010393 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 216596010394 HSP70 interaction site [polypeptide binding]; other site 216596010395 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 216596010396 dimer interface [polypeptide binding]; other site 216596010397 Pfam match to entry PF01556.7 DnaJ_C 216596010398 Pfam match to entry PF00226.13 DnaJ 216596010399 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 216596010400 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 216596010401 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 216596010402 Pfam match to entry PF01243.8 Pyridox_oxidase 216596010403 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 216596010404 Putative catalytic NodB homology domain of Mesorhizobium loti Mlr8448 protein and its bacterial homologs; Region: CE4_Mlr8448_like_5s; cd10968 216596010405 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 216596010406 Pfam match to entry PF01522.9 Polysacc_deac_1 216596010407 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 216596010408 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 216596010409 Sporulation related domain; Region: SPOR; cl10051 216596010410 1 probable transmembrane helix predicted at aa 41-63 216596010411 Pfam match to entry PF00768.8 Peptidase_S11 216596010412 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria; Region: NTP-PPase_u1; cd11538 216596010413 metal binding site [ion binding]; metal-binding site 216596010414 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216596010415 Coenzyme A binding pocket [chemical binding]; other site 216596010416 Pfam match to entry PF00583.9 Acetyltransf_1 216596010417 protease TldD; Provisional; Region: tldD; PRK10735 216596010418 Pfam match to entry PF01523.6 PmbA_TldD 216596010419 Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342 216596010420 Pfam match to entry PF06776.1 IalB 216596010421 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00051 216596010422 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 216596010423 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 216596010424 3 probable transmembrane helices predicted at aa 5-23, 49-71 and 92-114 216596010425 Pfam match to entry PF02790.4 COX2_TM 216596010426 Pfam match to entry PF00116.8 COX2 216596010427 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 216596010428 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 216596010429 Subunit I/III interface [polypeptide binding]; other site 216596010430 D-pathway; other site 216596010431 Subunit I/VIIc interface [polypeptide binding]; other site 216596010432 Subunit I/IV interface [polypeptide binding]; other site 216596010433 Subunit I/II interface [polypeptide binding]; other site 216596010434 Low-spin heme (heme a) binding site [chemical binding]; other site 216596010435 Subunit I/VIIa interface [polypeptide binding]; other site 216596010436 Subunit I/VIa interface [polypeptide binding]; other site 216596010437 Dimer interface; other site 216596010438 Putative water exit pathway; other site 216596010439 Binuclear center (heme a3/CuB) [ion binding]; other site 216596010440 K-pathway; other site 216596010441 Subunit I/Vb interface [polypeptide binding]; other site 216596010442 Putative proton exit pathway; other site 216596010443 Subunit I/VIb interface; other site 216596010444 Subunit I/VIc interface [polypeptide binding]; other site 216596010445 Electron transfer pathway; other site 216596010446 Subunit I/VIIIb interface [polypeptide binding]; other site 216596010447 Subunit I/VIIb interface [polypeptide binding]; other site 216596010448 Pfam match to entry PF00115.8 COX1 216596010449 12 probable transmembrane helices predicted at aa 46-68, 106-128, 149-171, 200-222,235-257, 290-312, 319-341, 356-378, 390-412, 427-449,461-483 and 503-525 216596010450 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 216596010451 UbiA prenyltransferase family; Region: UbiA; pfam01040 216596010452 9 probable transmembrane helices predicted at aa 32-51, 55-77, 98-120, 124-145,152-171, 175-197, 226-248, 252-271 and 284-301 216596010453 Pfam match to entry PF01040.7 UbiA 216596010454 1 probable transmembrane helix predicted at aa 21-43 216596010455 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 216596010456 1 probable transmembrane helix predicted at aa 15-37 216596010457 Pfam match to entry PF04442.3 CtaG_Cox11 216596010458 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 216596010459 Subunit III/VIIa interface [polypeptide binding]; other site 216596010460 Phospholipid binding site [chemical binding]; other site 216596010461 Subunit I/III interface [polypeptide binding]; other site 216596010462 Subunit III/VIb interface [polypeptide binding]; other site 216596010463 Subunit III/VIa interface; other site 216596010464 Subunit III/Vb interface [polypeptide binding]; other site 216596010465 Pfam match to entry PF00510.8 COX3 216596010466 7 probable transmembrane helices predicted at aa 21-38, 53-75, 92-114, 153-175,182-204, 219-241 and 262-284 216596010467 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cl17391 216596010468 P-loop motif; other site 216596010469 ATP binding site [chemical binding]; other site 216596010470 Chloramphenicol (Cm) binding site [chemical binding]; other site 216596010471 catalytic residue [active] 216596010472 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349 216596010473 Pfam match to entry PF06170.1 DUF983 216596010474 2 probable transmembrane helices predicted at aa 58-80 and 84-106 216596010475 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 216596010476 Pfam match to entry PF02104.5 SURF1 216596010477 2 probable transmembrane helices predicted at aa 13-35 and 223-242 216596010478 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 216596010479 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 216596010480 Pfam match to entry PF02401.5 LYTB 216596010481 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 216596010482 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 216596010483 putative active site [active] 216596010484 putative substrate binding site [chemical binding]; other site 216596010485 ATP binding site [chemical binding]; other site 216596010486 Pfam match to entry PF01636.8 APH 216596010487 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 216596010488 RNA/DNA hybrid binding site [nucleotide binding]; other site 216596010489 active site 216596010490 Pfam match to entry PF00075.10 RnaseH 216596010491 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 216596010492 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 216596010493 CsbD-like; Region: CsbD; pfam05532 216596010494 Pfam match to entry PF05532.1 CsbD 216596010495 hypothetical protein; Validated; Region: PRK00228 216596010496 Pfam match to entry PF02622.4 DUF179 216596010497 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 216596010498 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 216596010499 catalytic triad [active] 216596010500 dimer interface [polypeptide binding]; other site 216596010501 Pfam match to entry PF00578.7 AhpC-TSA 216596010502 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 216596010503 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 216596010504 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 216596010505 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596010506 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 216596010507 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216596010508 dimerization interface [polypeptide binding]; other site 216596010509 Pfam match to entry PF00126.10 HTH_1 216596010510 Pfam match to entry PF03466.5 LysR_substrate 216596010511 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 216596010512 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 216596010513 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 216596010514 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 216596010515 Walker A/P-loop; other site 216596010516 ATP binding site [chemical binding]; other site 216596010517 Q-loop/lid; other site 216596010518 ABC transporter signature motif; other site 216596010519 Walker B; other site 216596010520 D-loop; other site 216596010521 H-loop/switch region; other site 216596010522 Pfam match to entry PF00005.11 ABC_tran 216596010523 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 216596010524 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 216596010525 substrate binding pocket [chemical binding]; other site 216596010526 membrane-bound complex binding site; other site 216596010527 hinge residues; other site 216596010528 Pfam match to entry PF00497.8 SBP_bac_3 216596010529 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 216596010530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596010531 dimer interface [polypeptide binding]; other site 216596010532 conserved gate region; other site 216596010533 putative PBP binding loops; other site 216596010534 ABC-ATPase subunit interface; other site 216596010535 Pfam match to entry PF00528.10 BPD_transp_1 216596010536 5 probable transmembrane helices predicted at aa 15-37, 58-80, 85-104, 154-176 and 191-213 216596010537 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596010538 dimer interface [polypeptide binding]; other site 216596010539 conserved gate region; other site 216596010540 ABC-ATPase subunit interface; other site 216596010541 Pfam match to entry PF00528.10 BPD_transp_1 216596010542 5 probable transmembrane helices predicted at aa 20-42, 55-77, 97-119, 153-175 and 195-217 216596010543 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 216596010544 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 216596010545 Pfam match to entry PF00005.11 ABC_tran 216596010546 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 216596010547 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 216596010548 ABC-ATPase subunit interface; other site 216596010549 dimer interface [polypeptide binding]; other site 216596010550 putative PBP binding regions; other site 216596010551 Pfam match to entry PF00950.7 ABC-3 216596010552 7 probable transmembrane helices predicted at aa 21-40, 60-82, 103-125, 140-162,183-205, 225-247 and 254-276 216596010553 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 216596010554 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 216596010555 metal binding site [ion binding]; metal-binding site 216596010556 Pfam match to entry PF01297.7 SBP_bac_9 216596010557 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 216596010558 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 216596010559 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 216596010560 homotrimer interaction site [polypeptide binding]; other site 216596010561 putative active site [active] 216596010562 Pfam match to entry PF01042.8 Ribonuc_L-PSP 216596010563 tetracycline repressor protein TetR; Provisional; Region: PRK13756 216596010564 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216596010565 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 216596010566 Pfam match to entry PF00440.8 TetR_N 216596010567 Pfam match to entry PF02909.5 TetR_C 216596010568 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 216596010569 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 216596010570 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 216596010571 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 216596010572 active site 216596010573 HIGH motif; other site 216596010574 nucleotide binding site [chemical binding]; other site 216596010575 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 216596010576 KMSK motif region; other site 216596010577 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 216596010578 tRNA binding surface [nucleotide binding]; other site 216596010579 anticodon binding site; other site 216596010580 Pfam match to entry PF05746.3 tRNA-synt_1d_C 216596010581 Pfam match to entry PF00750.8 tRNA-synt_1d 216596010582 Pfam match to entry PF03485.5 Arg_tRNA_synt_N 216596010583 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 216596010584 Domain of unknown function (DUF4401); Region: DUF4401; pfam14351 216596010585 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 216596010586 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216596010587 PAS fold; Region: PAS_3; pfam08447 216596010588 putative active site [active] 216596010589 heme pocket [chemical binding]; other site 216596010590 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 216596010591 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216596010592 metal binding site [ion binding]; metal-binding site 216596010593 active site 216596010594 I-site; other site 216596010595 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216596010596 Pfam match to entry PF00563.9 EAL 216596010597 Pfam match to entry PF00990.8 GGDEF 216596010598 Pfam match to entry PF00785.11 PAC 216596010599 8 probable transmembrane helices predicted at aa 15-34, 195-217, 227-249, 256-278,288-307, 314-336, 341-363 and 375-397 216596010600 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 216596010601 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 216596010602 Pfam match to entry PF00583.9 Acetyltransf_1 216596010603 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 216596010604 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 216596010605 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 216596010606 Pfam match to entry PF05193.5 Peptidase_M16_C 216596010607 Pfam match to entry PF00675.9 Peptidase_M16 216596010608 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 216596010609 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 216596010610 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596010611 catalytic residue [active] 216596010612 Pfam match to entry PF00291.10 PALP 216596010613 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 216596010614 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 216596010615 motif II; other site 216596010616 Pfam match to entry PF00702.10 Hydrolase 216596010617 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 216596010618 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 216596010619 dimer interface [polypeptide binding]; other site 216596010620 putative CheW interface [polypeptide binding]; other site 216596010621 Pfam match to entry PF00015.9 MCPsignal 216596010622 Pfam match to entry PF00672.10 HAMP 216596010623 1 probable transmembrane helix predicted at aa 7-29 216596010624 2 probable transmembrane helices predicted at aa 15-37 and 101-123 216596010625 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 216596010626 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 216596010627 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 216596010628 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 216596010629 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 216596010630 Autotransporter beta-domain; Region: Autotransporter; smart00869 216596010631 Pfam match to entry PF05594.2 Fil_haemagg 216596010632 Pfam match to entry PF05594.2 Fil_haemagg 216596010633 Pfam match to entry PF03797.5 Autotransporter 216596010634 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216596010635 putative DNA binding site [nucleotide binding]; other site 216596010636 dimerization interface [polypeptide binding]; other site 216596010637 Pfam match to entry PF01022.8 HTH_5 216596010638 NIPSNAP; Region: NIPSNAP; pfam07978 216596010639 Pfam match to entry PF06499.1 DUF1099 216596010640 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 216596010641 Pfam match to entry PF03992.3 ABM 216596010642 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 216596010643 DNA methylase; Region: N6_N4_Mtase; pfam01555 216596010644 Pfam match to entry PF01555.6 N6_N4_Mtase 216596010645 SnoaL-like domain; Region: SnoaL_2; pfam12680 216596010646 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 216596010647 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 216596010648 Pfam match to entry PF00702.10 Hydrolase 216596010649 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 216596010650 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 216596010651 minor groove reading motif; other site 216596010652 helix-hairpin-helix signature motif; other site 216596010653 substrate binding pocket [chemical binding]; other site 216596010654 active site 216596010655 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 216596010656 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 216596010657 DNA binding and oxoG recognition site [nucleotide binding] 216596010658 Pfam match to entry PF00730.11 HhH-GPD 216596010659 Pfam match to entry PF00633.11 HHH 216596010660 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5389 216596010661 Pfam match to entry PF06647.1 DUF1159 216596010662 submitted without /pseudo; similarity:fasta; with=UniProt:FIC_ECOLI (EMBL:CEK131F3R); Escherichia coli.; fic; Cell filamentation protein fic.; length=200; id 37.324; 142 aa overlap; query 8-145; subject 10-148; similarity:fasta; with=UniProt:Y4LH_RHISN (EMBL:RSAE83); Rhizobium sp. (strain NGR234).; Hypothetical 22.4 kDa protein y4lH.; length=192; id 61.806; 144 aa overlap; query 3-145; subject 4-147 216596010663 Pfam match to entry PF02661.6 Fic 216596010664 TraY domain; Region: TraY; pfam05509 216596010665 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 216596010666 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 216596010667 catalytic residues [active] 216596010668 Pfam match to entry PF01323.9 DSBA 216596010669 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 216596010670 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 216596010671 Walker A/P-loop; other site 216596010672 ATP binding site [chemical binding]; other site 216596010673 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 216596010674 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 216596010675 ABC transporter signature motif; other site 216596010676 Walker B; other site 216596010677 D-loop; other site 216596010678 H-loop/switch region; other site 216596010679 Pfam match to entry PF02463.6 SMC_N 216596010680 Pfam match to entry PF06470.1 SMC_hinge 216596010681 Pfam match to entry PF02483.5 SMC_C 216596010682 pyruvate phosphate dikinase; Provisional; Region: PRK09279 216596010683 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 216596010684 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 216596010685 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 216596010686 Pfam match to entry PF01326.7 PPDK_N 216596010687 Pfam match to entry PF00391.9 PEP-utilizers 216596010688 Pfam match to entry PF02896.6 PEP-utilizers_C 216596010689 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 216596010690 3 probable transmembrane helices predicted at aa 29-51, 58-80 and 90-112 216596010691 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 216596010692 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 216596010693 Pfam match to entry PF04134.2 DUF393 216596010694 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 216596010695 Pfam match to entry PF00753.12 Lactamase_B 216596010696 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 216596010697 active site 216596010698 NTP binding site [chemical binding]; other site 216596010699 metal binding triad [ion binding]; metal-binding site 216596010700 Pfam match to entry PF01909.9 NTP_transf_2 216596010701 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 216596010702 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 216596010703 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 216596010704 Pfam match to entry PF01420.8 Methylase_S 216596010705 Pfam match to entry PF01420.8 Methylase_S 216596010706 HsdM N-terminal domain; Region: HsdM_N; pfam12161 216596010707 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 216596010708 Methyltransferase domain; Region: Methyltransf_26; pfam13659 216596010709 Pfam match to entry PF02384.5 N6_Mtase 216596010710 Pfam match to entry PF02506.4 Methylase_M 216596010711 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 216596010712 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 216596010713 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 216596010714 ATP binding site [chemical binding]; other site 216596010715 putative Mg++ binding site [ion binding]; other site 216596010716 nucleotide binding region [chemical binding]; other site 216596010717 helicase superfamily c-terminal domain; Region: HELICc; smart00490 216596010718 ATP-binding site [chemical binding]; other site 216596010719 Pfam match to entry PF00271.13 Helicase_C 216596010720 Pfam match to entry PF00270.12 DEAD 216596010721 Pfam match to entry PF04851.3 ResIII 216596010722 Pfam match to entry PF04313.2 HSDR_N 216596010723 Protein of unknown function DUF91; Region: DUF91; cl00709 216596010724 Uncharacterized conserved protein [Function unknown]; Region: COG3586 216596010725 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 216596010726 daunorubicin C-13 ketoreductase (KR), classical (c)-like SDRs; Region: DR_C-13_KR_SDR_c_like; cd08951 216596010727 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 216596010728 putative NAD(P) binding site [chemical binding]; other site 216596010729 active site 216596010730 Pfam match to entry PF00106.11 adh_short 216596010731 WHG domain; Region: WHG; pfam13305 216596010732 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 216596010733 Pfam match to entry PF04012.2 PspA_IM30 216596010734 yiaA/B two helix domain; Region: YiaAB; cl01759 216596010735 1 probable transmembrane helix predicted at aa 12-34 216596010736 acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814 216596010737 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596010738 putative substrate translocation pore; other site 216596010739 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 216596010740 putative acyl-acceptor binding pocket; other site 216596010741 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 216596010742 acyl-activating enzyme (AAE) consensus motif; other site 216596010743 putative AMP binding site [chemical binding]; other site 216596010744 11 probable transmembrane helices predicted at aa 46-68, 88-121, 142-164, 169-186,226-248, 258-280, 285-307, 332-354, 366-388, 392-414 and 679-701 216596010745 Pfam match to entry PF01553.9 Acyltransferase 216596010746 Pfam match to entry PF00501.11 AMP-binding 216596010747 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 216596010748 oligomeric interface; other site 216596010749 putative active site [active] 216596010750 homodimer interface [polypeptide binding]; other site 216596010751 Pfam match to entry PF01850.8 PIN 216596010752 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 216596010753 Bacterial PH domain; Region: DUF304; cl01348 216596010754 3 probable transmembrane helices predicted at aa 12-29, 39-61 and 68-90 216596010755 SnoaL-like domain; Region: SnoaL_3; pfam13474 216596010756 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 216596010757 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 216596010758 DNA binding residues [nucleotide binding] 216596010759 dimerization interface [polypeptide binding]; other site 216596010760 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 216596010761 Catalytic site [active] 216596010762 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 216596010763 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 216596010764 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216596010765 DNA binding residues [nucleotide binding] 216596010766 dimerization interface [polypeptide binding]; other site 216596010767 Pfam match to entry PF00196.8 GerE 216596010768 NIPSNAP; Region: NIPSNAP; pfam07978 216596010769 Carboxylesterase family; Region: COesterase; pfam00135 216596010770 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 216596010771 substrate binding pocket [chemical binding]; other site 216596010772 catalytic triad [active] 216596010773 Pfam match to entry PF00135.13 COesterase 216596010774 Uncharacterized conserved protein [Function unknown]; Region: COG5361 216596010775 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 216596010776 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 216596010777 Pfam match to entry PF06742.1 DUF1214 216596010778 Pfam match to entry PF06863.1 DUF1254 216596010779 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 216596010780 cyclase homology domain; Region: CHD; cd07302 216596010781 nucleotidyl binding site; other site 216596010782 metal binding site [ion binding]; metal-binding site 216596010783 dimer interface [polypeptide binding]; other site 216596010784 Predicted integral membrane protein [Function unknown]; Region: COG5616 216596010785 TPR repeat; Region: TPR_11; pfam13414 216596010786 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216596010787 TPR motif; other site 216596010788 binding surface 216596010789 Tetratricopeptide repeat; Region: TPR_16; pfam13432 216596010790 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216596010791 TPR motif; other site 216596010792 binding surface 216596010793 TPR repeat; Region: TPR_11; pfam13414 216596010794 Pfam match to entry PF00211.9 Guanylate_cyc 216596010795 Pfam match to entry PF00515.11 TPR 216596010796 Pfam match to entry PF00515.11 TPR 216596010797 Pfam match to entry PF00515.11 TPR 216596010798 Pfam match to entry PF00515.11 TPR 216596010799 Pfam match to entry PF00515.11 TPR 216596010800 Predicted kinase [General function prediction only]; Region: COG0645 216596010801 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 216596010802 8 probable transmembrane helices predicted at aa 7-29, 44-63, 70-92, 102-119,140-162, 172-194, 201-223 and 233-255 216596010803 Pfam match to entry PF01925.8 DUF81 216596010804 Predicted transporter component [General function prediction only]; Region: COG2391 216596010805 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 216596010806 4 probable transmembrane helices predicted at aa 7-29, 44-66, 73-93 and 113-135 216596010807 Pfam match to entry PF04143.3 DUF395 216596010808 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216596010809 dimerization interface [polypeptide binding]; other site 216596010810 putative DNA binding site [nucleotide binding]; other site 216596010811 putative Zn2+ binding site [ion binding]; other site 216596010812 Pfam match to entry PF01022.8 HTH_5 216596010813 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3453 216596010814 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 216596010815 Pfam match to entry PF00753.12 Lactamase_B 216596010816 Pfam match to entry PF04273.2 DUF442 216596010817 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 216596010818 Pfam match to entry PF05425.2 CopD 216596010819 4 probable transmembrane helices predicted at aa 76-98, 118-140, 155-177 and 190-212 216596010820 Domain of unknown function (DUF305); Region: DUF305; cl17794 216596010821 1 probable transmembrane helix predicted at aa 21-40 216596010822 Pfam match to entry PF03713.3 DUF305 216596010823 Uncharacterized conserved protein [Function unknown]; Region: COG3391 216596010824 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 216596010825 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 216596010826 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 216596010827 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 216596010828 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216596010829 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 216596010830 DNA binding residues [nucleotide binding] 216596010831 Pfam match to entry PF04542.2 Sigma70_r2 216596010832 Pfam match to entry PF04545.3 Sigma70_r4 216596010833 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 216596010834 1 probable transmembrane helix predicted at aa 83-105 216596010835 conserved hypothetical protein, pseudogene; N-terminus to codon 43 is similar to N-terminus to codon 42 of Deinococcus radiodurans hypothetical protein dr2467. UniProt:Q9RRM1_DEIRA (EMBL:H75269) (168 aa); similarity:fasta; with=UniProt:Q9RRM1_DEIRA (EMBL:H75269); Deinococcus radiodurans.; Hypothetical protein DR2467.; length=168; id 60.000; 40 aa overlap; query 2-41; subject 3-42 216596010836 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216596010837 DNA binding site [nucleotide binding] 216596010838 Predicted integral membrane protein [Function unknown]; Region: COG5616 216596010839 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216596010840 TPR motif; other site 216596010841 binding surface 216596010842 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216596010843 TPR motif; other site 216596010844 Pfam match to entry PF00486.11 Trans_reg_C 216596010845 transcriptional regulator, pseudogene; Similar to C-terminus from codon 225 of Bradyrhizobium japonicum transcriptional regulatory protein. UniProt:Q89N42 (293 aa); similarity:fasta; with=UniProt:Q89N42; Bradyrhizobium japonicum.; Transcriptional regulatory protein.; length=293; id 76.389; 72 aa overlap; query 14-85; subject 222-293 216596010846 Pfam match to entry PF06445.1 AraC_E_bind 216596010847 AAA domain; Region: AAA_17; pfam13207 216596010848 Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile. CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902 216596010849 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 216596010850 Pfam match to entry PF02275.7 CBAH 216596010851 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596010852 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 216596010853 Sulfatase; Region: Sulfatase; pfam00884 216596010854 Pfam match to entry PF00884.10 Sulfatase 216596010855 Uncharacterized conserved protein [Function unknown]; Region: COG5361 216596010856 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 216596010857 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 216596010858 Pfam match to entry PF06863.1 DUF1254 216596010859 Pfam match to entry PF06742.1 DUF1214 216596010860 4 probable transmembrane helices predicted at aa 7-26, 41-58, 71-88 and 93-115 216596010861 transposase, pseudogene; Codons 38 to the C-terminus are similar to codons 158 to the C-terminus of Escherichia coli TnpR. UniProt:Q6SJ77_ECOLI (EMBL:AY458016) (201 aa); similarity:fasta; with=UniProt:Q6SJ77_ECOLI (EMBL:AY458016); Escherichia coli.; TnpR.; length=201; id 61.364; 44 aa overlap; query 38-81; subject 156-199 216596010862 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 216596010863 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 216596010864 Pfam match to entry PF01755.7 Glyco_transf_25 216596010865 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 216596010866 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216596010867 dimer interface [polypeptide binding]; other site 216596010868 phosphorylation site [posttranslational modification] 216596010869 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596010870 ATP binding site [chemical binding]; other site 216596010871 Mg2+ binding site [ion binding]; other site 216596010872 G-X-G motif; other site 216596010873 Pfam match to entry PF02518.9 HATPase_c 216596010874 Pfam match to entry PF00512.10 HisKA 216596010875 Pfam match to entry PF00672.10 HAMP 216596010876 2 probable transmembrane helices predicted at aa 12-34 and 155-177 216596010877 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 216596010878 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596010879 active site 216596010880 phosphorylation site [posttranslational modification] 216596010881 intermolecular recognition site; other site 216596010882 dimerization interface [polypeptide binding]; other site 216596010883 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216596010884 DNA binding site [nucleotide binding] 216596010885 Pfam match to entry PF00486.11 Trans_reg_C 216596010886 Pfam match to entry PF00072.9 Response_reg 216596010887 transposase, pseudogene; Codons 27 to the C-terminus are similar to codons 238 to the C-terminus of Alteromonas atlantica (Pseudomonas atlantica) DNA with insertion element is492 gene encoding reversible inactivation of extracellular polysaccharide production, complete CDS. UniProt:Q51474_ALTAT (EMBL:A32816) (318 aa), and codons 28 to the C-terminus are similar to codons 245 to the C-terminus of Klebsiella pneumoniae transposase. UniProt:Q6U5I5_KLEPN (EMBL:AY378100) (328 aa); similarity:fasta; with=UniProt:Q51474_ALTAT (EMBL:A32816); Alteromonas atlantica (Pseudomonas atlantica).; DNA with insertion element IS492 gene encoding reversible inactivation of extracellular polysaccharide production, complete cds.; length=318; id 46.250; 80 aa overlap; query 26-105; subject 237-315; similarity:fasta; with=UniProt:Q6U5I5_KLEPN (EMBL:AY378100); Klebsiella pneumoniae.; Transposase.; length=328; id 49.383; 81 aa overlap; query 27-107; subject 245-325 216596010888 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 216596010889 Pfam match to entry PF06249.1 EutQ 216596010890 Cytochrome c; Region: Cytochrom_C; cl11414 216596010891 Cytochrome c; Region: Cytochrom_C; cl11414 216596010892 Pfam match to entry PF00034.8 Cytochrom_C 216596010893 hypothetical protein; Provisional; Region: PRK06486 216596010894 intersubunit interface [polypeptide binding]; other site 216596010895 active site 216596010896 Zn2+ binding site [ion binding]; other site 216596010897 Pfam match to entry PF00596.9 Aldolase_II 216596010898 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596010899 active site 216596010900 phosphorylation site [posttranslational modification] 216596010901 intermolecular recognition site; other site 216596010902 dimerization interface [polypeptide binding]; other site 216596010903 Pfam match to entry PF00072.9 Response_reg 216596010904 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216596010905 PAS domain; Region: PAS_9; pfam13426 216596010906 putative active site [active] 216596010907 heme pocket [chemical binding]; other site 216596010908 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 216596010909 Histidine kinase; Region: HisKA_2; pfam07568 216596010910 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596010911 ATP binding site [chemical binding]; other site 216596010912 Mg2+ binding site [ion binding]; other site 216596010913 G-X-G motif; other site 216596010914 Pfam match to entry PF02518.9 HATPase_c 216596010915 Pfam match to entry PF07568.1 HisKA_2 216596010916 2 probable transmembrane helices predicted at aa 55-77 and 87-109 216596010917 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 216596010918 homotrimer interaction site [polypeptide binding]; other site 216596010919 putative active site [active] 216596010920 Pfam match to entry PF01042.8 Ribonuc_L-PSP 216596010921 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216596010922 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216596010923 Pfam match to entry PF00440.8 TetR_N 216596010924 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216596010925 dimerization interface [polypeptide binding]; other site 216596010926 putative DNA binding site [nucleotide binding]; other site 216596010927 putative Zn2+ binding site [ion binding]; other site 216596010928 Pfam match to entry PF01022.8 HTH_5 216596010929 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 216596010930 putative hydrophobic ligand binding site [chemical binding]; other site 216596010931 Pfam match to entry PF05146.3 DUF704 216596010932 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 216596010933 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 216596010934 oligomer interface [polypeptide binding]; other site 216596010935 active site residues [active] 216596010936 Pfam match to entry PF00574.9 CLP_protease 216596010937 Predicted membrane protein [Function unknown]; Region: COG2261 216596010938 3 probable transmembrane helices predicted at aa 38-60, 72-94 and 98-120 216596010939 Pfam match to entry PF04226.2 Transgly_assoc 216596010940 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 216596010941 Pfam match to entry PF06823.1 DUF1236 216596010942 2 probable transmembrane helices predicted at aa 5-27 and 37-59 216596010943 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 216596010944 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 216596010945 Pfam match to entry PF01545.9 Cation_efflux 216596010946 5 probable transmembrane helices predicted at aa 60-82, 87-106, 126-145, 155-177 and 205-238 216596010947 Alcaligenes xylosoxidans NreA and related domains; this domain family was previously known as part of DUF156; Region: NreA-like_DUF156; cd10154 216596010948 putative homodimer interface [polypeptide binding]; other site 216596010949 putative homotetramer interface [polypeptide binding]; other site 216596010950 putative metal binding site [ion binding]; other site 216596010951 putative homodimer-homodimer interface [polypeptide binding]; other site 216596010952 putative allosteric switch controlling residues; other site 216596010953 Pfam match to entry PF02583.4 DUF156 216596010954 Predicted membrane protein [Function unknown]; Region: COG1238 216596010955 1 probable transmembrane helix predicted at aa 20-42 216596010956 High-affinity nickel-transport protein; Region: NicO; cl00964 216596010957 6 probable transmembrane helices predicted at aa 23-45, 72-94, 109-131, 144-166,176-198 and 219-241 216596010958 Pfam match to entry PF03824.5 NicO 216596010959 Phage-related protein [Function unknown]; Region: COG4695; cl01923 216596010960 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 216596010961 Pfam match to entry PF01243.8 Pyridox_oxidase 216596010962 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 216596010963 Pfam match to entry PF02522.4 Antibiotic_NAT 216596010964 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 216596010965 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 216596010966 Pfam match to entry PF01243.8 Pyridox_oxidase 216596010967 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 216596010968 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 216596010969 putative NAD(P) binding site [chemical binding]; other site 216596010970 putative active site [active] 216596010971 Pfam match to entry PF00106.11 adh_short 216596010972 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 216596010973 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596010974 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 216596010975 dimerization interface [polypeptide binding]; other site 216596010976 substrate binding pocket [chemical binding]; other site 216596010977 Pfam match to entry PF00126.10 HTH_1 216596010978 Pfam match to entry PF03466.5 LysR_substrate 216596010979 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 216596010980 cyclase homology domain; Region: CHD; cd07302 216596010981 nucleotidyl binding site; other site 216596010982 metal binding site [ion binding]; metal-binding site 216596010983 dimer interface [polypeptide binding]; other site 216596010984 Predicted integral membrane protein [Function unknown]; Region: COG5616 216596010985 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216596010986 TPR motif; other site 216596010987 binding surface 216596010988 TPR repeat; Region: TPR_11; pfam13414 216596010989 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216596010990 TPR motif; other site 216596010991 binding surface 216596010992 Pfam match to entry PF00211.9 Guanylate_cyc 216596010993 Pfam match to entry PF00515.11 TPR 216596010994 Phosphotransferase enzyme family; Region: APH; pfam01636 216596010995 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 216596010996 active site 216596010997 ATP binding site [chemical binding]; other site 216596010998 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216596010999 dimerization interface [polypeptide binding]; other site 216596011000 putative DNA binding site [nucleotide binding]; other site 216596011001 putative Zn2+ binding site [ion binding]; other site 216596011002 Pfam match to entry PF01022.8 HTH_5 216596011003 Protein of unknown function (DUF805); Region: DUF805; pfam05656 216596011004 Pfam match to entry PF05656.1 DUF805 216596011005 3 probable transmembrane helices predicted at aa 16-38, 48-70 and 98-120 216596011006 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216596011007 dimerization interface [polypeptide binding]; other site 216596011008 putative DNA binding site [nucleotide binding]; other site 216596011009 putative Zn2+ binding site [ion binding]; other site 216596011010 Pfam match to entry PF01022.8 HTH_5 216596011011 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 216596011012 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216596011013 NAD(P) binding site [chemical binding]; other site 216596011014 active site 216596011015 Pfam match to entry PF00106.11 adh_short 216596011016 BA14K-like protein; Region: BA14K; pfam07886 216596011017 2 probable transmembrane helices predicted at aa 21-43 and 97-119 216596011018 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 216596011019 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 216596011020 Autotransporter beta-domain; Region: Autotransporter; smart00869 216596011021 Pfam match to entry PF03797.5 Autotransporter 216596011022 Pfam match to entry PF05594.2 Fil_haemagg 216596011023 Pfam match to entry PF05594.2 Fil_haemagg 216596011024 2 probable transmembrane helices predicted at aa 10-29 and 36-58 216596011025 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 216596011026 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216596011027 NAD(P) binding site [chemical binding]; other site 216596011028 active site 216596011029 Pfam match to entry PF00106.11 adh_short 216596011030 Uncharacterized conserved protein [Function unknown]; Region: COG1359 216596011031 Pfam match to entry PF03992.3 ABM 216596011032 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 216596011033 active site 216596011034 Pfam match to entry PF00903.11 Glyoxalase 216596011035 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216596011036 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596011037 putative substrate translocation pore; other site 216596011038 12 probable transmembrane helices predicted at aa 5-27, 37-59, 68-86, 96-118,125-147, 157-179, 206-228, 238-260, 267-285, 295-317,329-351 and 361-378 216596011039 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216596011040 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 216596011041 DNA binding site [nucleotide binding] 216596011042 Predicted ATPase [General function prediction only]; Region: COG3903 216596011043 Pfam match to entry PF06492.1 DUF1095 216596011044 Pfam match to entry PF06498.1 Ad_Cycl_assoc 216596011045 Pfam match to entry PF00486.11 Trans_reg_C 216596011046 transcriptional regulator; Provisional; Region: PRK10632 216596011047 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596011048 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 216596011049 putative effector binding pocket; other site 216596011050 putative dimerization interface [polypeptide binding]; other site 216596011051 Pfam match to entry PF03466.5 LysR_substrate 216596011052 Pfam match to entry PF00126.10 HTH_1 216596011053 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 216596011054 Pfam match to entry PF00753.12 Lactamase_B 216596011055 LysR family transcriptional regulator; Provisional; Region: PRK14997 216596011056 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596011057 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 216596011058 putative effector binding pocket; other site 216596011059 dimerization interface [polypeptide binding]; other site 216596011060 Pfam match to entry PF03466.5 LysR_substrate 216596011061 Pfam match to entry PF00126.10 HTH_1 216596011062 NmrA-like family; Region: NmrA; pfam05368 216596011063 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 216596011064 NADP binding site [chemical binding]; other site 216596011065 active site 216596011066 regulatory binding site [polypeptide binding]; other site 216596011067 DUF1857, an uncharacterized ligand-binding domain of the SRPBCC domain superfamily; Region: SRPBCC_DUF1857; cd08863 216596011068 putative hydrophobic ligand binding site [chemical binding]; other site 216596011069 Domain of unknown function (DUF303); Region: DUF303; pfam03629 216596011070 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 216596011071 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 216596011072 potential catalytic triad [active] 216596011073 conserved cys residue [active] 216596011074 Pfam match to entry PF01965.9 DJ-1_PfpI 216596011075 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 216596011076 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596011077 The C-terminal substrate binding of LysR-type symbiotic regulator SyrM, which activates expression of nodulation gene NodD3, contains the type 2 periplasmic binding fold; Region: PBP2_SyrM; cd08467 216596011078 putative substrate binding pocket [chemical binding]; other site 216596011079 putative dimerization interface [polypeptide binding]; other site 216596011080 Pfam match to entry PF00126.10 HTH_1 216596011081 Pfam match to entry PF03466.5 LysR_substrate 216596011082 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 216596011083 active site 216596011084 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 216596011085 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216596011086 Pfam match to entry PF00903.11 Glyoxalase 216596011087 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 216596011088 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 216596011089 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 216596011090 dimer interface [polypeptide binding]; other site 216596011091 substrate binding pocket (H-site) [chemical binding]; other site 216596011092 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 216596011093 N-terminal domain interface [polypeptide binding]; other site 216596011094 Pfam match to entry PF00043.11 GST_C 216596011095 Pfam match to entry PF02798.6 GST_N 216596011096 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 216596011097 putative hydrophobic ligand binding site [chemical binding]; other site 216596011098 Pfam match to entry PF05146.3 DUF704 216596011099 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216596011100 dimerization interface [polypeptide binding]; other site 216596011101 putative DNA binding site [nucleotide binding]; other site 216596011102 putative Zn2+ binding site [ion binding]; other site 216596011103 Pfam match to entry PF01022.8 HTH_5 216596011104 4 probable transmembrane helices predicted at aa 4-23, 36-58, 63-81 and 86-105 216596011105 Domain of unknown function (DUF4267); Region: DUF4267; pfam14087 216596011106 3 probable transmembrane helices predicted at aa 3-25, 74-96 and 103-125 216596011107 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216596011108 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216596011109 WHG domain; Region: WHG; pfam13305 216596011110 Pfam match to entry PF00440.8 TetR_N 216596011111 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894 216596011112 putative hydrophobic ligand binding site [chemical binding]; other site 216596011113 Pfam match to entry PF05146.3 DUF704 216596011114 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216596011115 dimerization interface [polypeptide binding]; other site 216596011116 putative DNA binding site [nucleotide binding]; other site 216596011117 putative Zn2+ binding site [ion binding]; other site 216596011118 Pfam match to entry PF01022.8 HTH_5 216596011119 RibD C-terminal domain; Region: RibD_C; cl17279 216596011120 Pfam match to entry PF01872.7 RibD_C 216596011121 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216596011122 dimerization interface [polypeptide binding]; other site 216596011123 putative DNA binding site [nucleotide binding]; other site 216596011124 putative Zn2+ binding site [ion binding]; other site 216596011125 Pfam match to entry PF01022.8 HTH_5 216596011126 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 216596011127 putative hydrophobic ligand binding site [chemical binding]; other site 216596011128 Pfam match to entry PF05146.3 DUF704 216596011129 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 216596011130 active site 216596011131 ATP binding site [chemical binding]; other site 216596011132 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 216596011133 cyclase homology domain; Region: CHD; cd07302 216596011134 nucleotidyl binding site; other site 216596011135 metal binding site [ion binding]; metal-binding site 216596011136 dimer interface [polypeptide binding]; other site 216596011137 Pfam match to entry PF00211.9 Guanylate_cyc 216596011138 Pfam match to entry PF00672.10 HAMP 216596011139 3 probable transmembrane helices predicted at aa 7-29, 318-340 and 352-374 216596011140 Pfam match to entry PF02743.5 Cache 216596011141 Short repeat of unknown function (DUF308); Region: DUF308; pfam03729 216596011142 6 probable transmembrane helices predicted at aa 21-40, 44-66, 79-98, 102-120,133-155 and 159-181 216596011143 1 probable transmembrane helix predicted at aa 5-27 216596011144 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216596011145 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216596011146 Pfam match to entry PF00440.8 TetR_N 216596011147 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 216596011148 Pfam match to entry PF02586.4 DUF159 216596011149 short chain dehydrogenase; Provisional; Region: PRK06180 216596011150 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 216596011151 NADP binding site [chemical binding]; other site 216596011152 active site 216596011153 steroid binding site; other site 216596011154 Pfam match to entry PF00106.11 adh_short 216596011155 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 216596011156 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216596011157 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216596011158 Pfam match to entry PF06719.1 AraC_N 216596011159 Pfam match to entry PF00165.8 HTH_AraC 216596011160 Pfam match to entry PF00165.8 HTH_AraC 216596011161 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216596011162 Pfam match to entry PF00440.8 TetR_N 216596011163 Pfam match to entry PF02178.6 AT_hook 216596011164 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 216596011165 putative dimer interface [polypeptide binding]; other site 216596011166 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216596011167 Pfam match to entry PF00903.11 Glyoxalase 216596011168 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 216596011169 Sulfatase; Region: Sulfatase; pfam00884 216596011170 Pfam match to entry PF00884.10 Sulfatase 216596011171 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 216596011172 Sulfatase; Region: Sulfatase; pfam00884 216596011173 Pfam match to entry PF00884.10 Sulfatase 216596011174 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 216596011175 Sulfatase; Region: Sulfatase; pfam00884 216596011176 Pfam match to entry PF00884.10 Sulfatase 216596011177 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 216596011178 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 216596011179 Pfam match to entry PF01738.6 DLH 216596011180 2 probable transmembrane helices predicted at aa 21-38 and 53-75 216596011181 large terminase protein; Provisional; Region: 17; PHA02533 216596011182 1 probable transmembrane helix predicted at aa 105-127 216596011183 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 216596011184 Pfam match to entry PF01243.8 Pyridox_oxidase 216596011185 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 216596011186 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 216596011187 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 216596011188 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 216596011189 protein binding site [polypeptide binding]; other site 216596011190 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 216596011191 protein binding site [polypeptide binding]; other site 216596011192 Pfam match to entry PF00595.8 PDZ 216596011193 Pfam match to entry PF00595.8 PDZ 216596011194 Pfam match to entry PF00089.9 Trypsin 216596011195 1 probable transmembrane helix predicted at aa 44-66 216596011196 Transcriptional regulators [Transcription]; Region: PurR; COG1609 216596011197 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216596011198 DNA binding site [nucleotide binding] 216596011199 domain linker motif; other site 216596011200 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 216596011201 putative dimerization interface [polypeptide binding]; other site 216596011202 putative ligand binding site [chemical binding]; other site 216596011203 Pfam match to entry PF00532.8 Peripla_BP_1 216596011204 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596011205 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596011206 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 216596011207 putative effector binding pocket; other site 216596011208 dimerization interface [polypeptide binding]; other site 216596011209 Pfam match to entry PF03466.5 LysR_substrate 216596011210 Pfam match to entry PF00126.10 HTH_1 216596011211 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 216596011212 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 216596011213 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 216596011214 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596011215 LysR family transcriptional regulator; Provisional; Region: PRK14997 216596011216 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 216596011217 putative effector binding pocket; other site 216596011218 dimerization interface [polypeptide binding]; other site 216596011219 Pfam match to entry PF00126.10 HTH_1 216596011220 Pfam match to entry PF03466.5 LysR_substrate 216596011221 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 216596011222 NmrA-like family; Region: NmrA; pfam05368 216596011223 NADP binding site [chemical binding]; other site 216596011224 active site 216596011225 regulatory binding site [polypeptide binding]; other site 216596011226 Pfam match to entry PF05368.1 NmrA 216596011227 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 216596011228 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 216596011229 NADP binding site [chemical binding]; other site 216596011230 dimer interface [polypeptide binding]; other site 216596011231 Pfam match to entry PF00107.10 ADH_zinc_N 216596011232 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596011233 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596011234 LysR substrate binding domain; Region: LysR_substrate; pfam03466 216596011235 dimerization interface [polypeptide binding]; other site 216596011236 Pfam match to entry PF00126.10 HTH_1 216596011237 Pfam match to entry PF03466.5 LysR_substrate 216596011238 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 216596011239 putative catalytic residues [active] 216596011240 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 216596011241 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 216596011242 CysD dimerization site [polypeptide binding]; other site 216596011243 G1 box; other site 216596011244 putative GEF interaction site [polypeptide binding]; other site 216596011245 GTP/Mg2+ binding site [chemical binding]; other site 216596011246 Switch I region; other site 216596011247 G2 box; other site 216596011248 G3 box; other site 216596011249 Switch II region; other site 216596011250 G4 box; other site 216596011251 G5 box; other site 216596011252 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 216596011253 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 216596011254 Pfam match to entry PF03144.8 GTP_EFTU_D2 216596011255 Pfam match to entry PF00009.10 GTP_EFTU 216596011256 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 216596011257 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 216596011258 Active Sites [active] 216596011259 Pfam match to entry PF01507.7 PAPS_reduct 216596011260 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 216596011261 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 216596011262 Active Sites [active] 216596011263 Pfam match to entry PF01507.7 PAPS_reduct 216596011264 Predicted transcriptional regulator [Transcription]; Region: COG1959 216596011265 Transcriptional regulator; Region: Rrf2; pfam02082 216596011266 Pfam match to entry PF02082.5 Rrf2 216596011267 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 216596011268 classical (c) SDRs; Region: SDR_c; cd05233 216596011269 NAD(P) binding site [chemical binding]; other site 216596011270 active site 216596011271 Pfam match to entry PF00106.11 adh_short 216596011272 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596011273 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596011274 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 216596011275 putative effector binding pocket; other site 216596011276 putative dimerization interface [polypeptide binding]; other site 216596011277 Pfam match to entry PF00126.10 HTH_1 216596011278 Pfam match to entry PF03466.5 LysR_substrate 216596011279 4 probable transmembrane helices predicted at aa 21-43, 63-85, 97-119 and 134-156 216596011280 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 216596011281 Pfam match to entry PF05016.2 Plasmid_stabil 216596011282 choline dehydrogenase; Validated; Region: PRK02106 216596011283 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 216596011284 Pfam match to entry PF05199.2 GMC_oxred_C 216596011285 Pfam match to entry PF00732.8 GMC_oxred_N 216596011286 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 216596011287 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 216596011288 tetrameric interface [polypeptide binding]; other site 216596011289 NAD binding site [chemical binding]; other site 216596011290 catalytic residues [active] 216596011291 Pfam match to entry PF00171.9 Aldedh 216596011292 transcriptional regulator BetI; Validated; Region: PRK00767 216596011293 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216596011294 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 216596011295 Pfam match to entry PF00440.8 TetR_N 216596011296 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 216596011297 6 probable transmembrane helices predicted at aa 13-35, 39-61, 73-95, 99-121,128-150 and 155-177 216596011298 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 216596011299 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216596011300 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 216596011301 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 216596011302 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216596011303 metal binding site [ion binding]; metal-binding site 216596011304 active site 216596011305 I-site; other site 216596011306 Pfam match to entry PF00563.9 EAL 216596011307 Pfam match to entry PF00571.13 CBS 216596011308 Pfam match to entry PF00571.13 CBS 216596011309 Pfam match to entry PF00990.8 GGDEF 216596011310 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 216596011311 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 216596011312 NAD(P) binding site [chemical binding]; other site 216596011313 Pfam match to entry PF00107.10 ADH_zinc_N 216596011314 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596011315 putative substrate translocation pore; other site 216596011316 13 probable transmembrane helices predicted at aa 31-53, 60-82, 92-114, 121-143,153-172, 185-204, 208-227, 248-270, 280-302, 309-331,346-368, 380-402 and 417-439 216596011317 Pfam match to entry PF00083.9 Sugar_tr 216596011318 Predicted transcriptional regulator [Transcription]; Region: COG2345 216596011319 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216596011320 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596011321 putative substrate translocation pore; other site 216596011322 12 probable transmembrane helices predicted at aa 21-40, 50-72, 81-100, 105-127,148-167, 171-193, 224-246, 256-277, 284-306, 311-333,346-368 and 373-392 216596011323 L-asparaginase II [Amino acid transport and metabolism]; Region: AnsA; COG4448 216596011324 Pfam match to entry PF06089.1 Asparaginase_II 216596011325 6 probable transmembrane helices predicted at aa 7-29, 80-102, 114-136, 151-168,175-197 and 207-229 216596011326 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 216596011327 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 216596011328 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 216596011329 Pfam match to entry PF00455.10 DeoR 216596011330 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cl00198 216596011331 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 216596011332 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 216596011333 C-terminal domain interface [polypeptide binding]; other site 216596011334 GSH binding site (G-site) [chemical binding]; other site 216596011335 dimer interface [polypeptide binding]; other site 216596011336 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 216596011337 dimer interface [polypeptide binding]; other site 216596011338 N-terminal domain interface [polypeptide binding]; other site 216596011339 substrate binding pocket (H-site) [chemical binding]; other site 216596011340 Pfam match to entry PF02798.6 GST_N 216596011341 Pfam match to entry PF00043.11 GST_C 216596011342 Protein of unknown function (DUF419); Region: DUF419; cl15265 216596011343 Pfam match to entry PF04944.2 DUF661 216596011344 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 216596011345 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596011346 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 216596011347 dimerization interface [polypeptide binding]; other site 216596011348 substrate binding pocket [chemical binding]; other site 216596011349 Pfam match to entry PF00126.10 HTH_1 216596011350 Pfam match to entry PF03466.5 LysR_substrate 216596011351 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 216596011352 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 216596011353 putative C-terminal domain interface [polypeptide binding]; other site 216596011354 putative GSH binding site (G-site) [chemical binding]; other site 216596011355 putative dimer interface [polypeptide binding]; other site 216596011356 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 216596011357 dimer interface [polypeptide binding]; other site 216596011358 N-terminal domain interface [polypeptide binding]; other site 216596011359 putative substrate binding pocket (H-site) [chemical binding]; other site 216596011360 Pfam match to entry PF00043.11 GST_C 216596011361 Pfam match to entry PF02798.6 GST_N 216596011362 twin-arg-translocated uncharacterized repeat protein; Region: RR_plus_rpt_1; TIGR03808 216596011363 PAS fold; Region: PAS_4; pfam08448 216596011364 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216596011365 putative active site [active] 216596011366 heme pocket [chemical binding]; other site 216596011367 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 216596011368 GAF domain; Region: GAF; pfam01590 216596011369 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 216596011370 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216596011371 metal binding site [ion binding]; metal-binding site 216596011372 active site 216596011373 I-site; other site 216596011374 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216596011375 Pfam match to entry PF00785.11 PAC 216596011376 Pfam match to entry PF01590.11 GAF 216596011377 Pfam match to entry PF00990.8 GGDEF 216596011378 Pfam match to entry PF00563.9 EAL 216596011379 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial homologs of mammalian glycerophosphodiester phosphodiesterase GDE4; Region: GDPD_GDE4_like_1; cd08613 216596011380 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 216596011381 putative active site [active] 216596011382 catalytic site [active] 216596011383 putative metal binding site [ion binding]; other site 216596011384 Pfam match to entry PF03009.6 GDPD 216596011385 1 probable transmembrane helix predicted at aa 5-27 216596011386 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216596011387 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 216596011388 Pfam match to entry PF00561.8 Abhydrolase_1 216596011389 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 216596011390 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 216596011391 DNA ligase, ATP-dependent, PP_1105 family; Region: DNA_lig_bact; TIGR04120 216596011392 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 216596011393 active site 216596011394 DNA binding site [nucleotide binding] 216596011395 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 216596011396 DNA binding site [nucleotide binding] 216596011397 Pfam match to entry PF01068.9 DNA_ligase_A_M 216596011398 Pfam match to entry PF04679.4 DNA_ligase_A_C 216596011399 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 216596011400 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 216596011401 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 216596011402 Pfam match to entry PF03734.4 ErfK_YbiS_YhnG 216596011403 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 216596011404 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 216596011405 Pfam match to entry PF03734.4 ErfK_YbiS_YhnG 216596011406 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 216596011407 DNA-binding site [nucleotide binding]; DNA binding site 216596011408 RNA-binding motif; other site 216596011409 Pfam match to entry PF00313.8 CSD 216596011410 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 216596011411 Pfam match to entry PF01165.7 Ribosomal_S21 216596011412 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 216596011413 MarR family; Region: MarR; pfam01047 216596011414 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 216596011415 Pfam match to entry PF02566.5 OsmC 216596011416 Transcriptional regulators [Transcription]; Region: MarR; COG1846 216596011417 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 216596011418 Pfam match to entry PF01047.8 MarR 216596011419 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4312 216596011420 Pfam match to entry PF05988.1 DUF899 216596011421 Protein of unknown function (DUF1579); Region: DUF1579; pfam07617 216596011422 Pfam match to entry PF07617.1 DUF1579 216596011423 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216596011424 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 216596011425 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216596011426 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 216596011427 Pfam match to entry PF00903.11 Glyoxalase 216596011428 Pfam match to entry PF00903.11 Glyoxalase 216596011429 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 216596011430 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 216596011431 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 216596011432 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 216596011433 Pfam match to entry PF00005.11 ABC_tran 216596011434 Pfam match to entry PF00005.11 ABC_tran 216596011435 4 probable transmembrane helices predicted at aa 21-43, 58-75, 87-109 and 129-151 216596011436 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 216596011437 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216596011438 Walker A/P-loop; other site 216596011439 ATP binding site [chemical binding]; other site 216596011440 ABC transporter signature motif; other site 216596011441 Walker B; other site 216596011442 D-loop; other site 216596011443 H-loop/switch region; other site 216596011444 ABC transporter; Region: ABC_tran_2; pfam12848 216596011445 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 216596011446 Pfam match to entry PF00005.11 ABC_tran 216596011447 Pfam match to entry PF00005.11 ABC_tran 216596011448 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 216596011449 Pfam match to entry PF05872.1 DUF853 216596011450 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 216596011451 nudix motif; other site 216596011452 Pfam match to entry PF00293.12 NUDIX 216596011453 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 216596011454 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 216596011455 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 216596011456 Pfam match to entry PF02781.4 G6PD_C 216596011457 Pfam match to entry PF00479.8 G6PD_N 216596011458 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 216596011459 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596011460 S-adenosylmethionine binding site [chemical binding]; other site 216596011461 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 216596011462 Domain of unknown function DUF21; Region: DUF21; pfam01595 216596011463 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 216596011464 Transporter associated domain; Region: CorC_HlyC; smart01091 216596011465 Pfam match to entry PF03471.5 CorC_HlyC 216596011466 Pfam match to entry PF00571.13 CBS 216596011467 Pfam match to entry PF00571.13 CBS 216596011468 Pfam match to entry PF01595.7 DUF21 216596011469 4 probable transmembrane helices predicted at aa 5-27, 57-79, 99-121 and 133-155 216596011470 Cache domain; Region: Cache_1; pfam02743 216596011471 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216596011472 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 216596011473 dimer interface [polypeptide binding]; other site 216596011474 putative CheW interface [polypeptide binding]; other site 216596011475 2 probable transmembrane helices predicted at aa 10-32 and 315-337 216596011476 Pfam match to entry PF02743.5 Cache 216596011477 Pfam match to entry PF00672.10 HAMP 216596011478 Pfam match to entry PF00015.9 MCPsignal 216596011479 topology modulation protein; Reviewed; Region: PRK08118 216596011480 AAA domain; Region: AAA_17; pfam13207 216596011481 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216596011482 Coenzyme A binding pocket [chemical binding]; other site 216596011483 Pfam match to entry PF00583.9 Acetyltransf_1 216596011484 Predicted kinase [General function prediction only]; Region: COG0645 216596011485 AAA domain; Region: AAA_17; pfam13207 216596011486 Cupin domain; Region: Cupin_2; pfam07883 216596011487 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 216596011488 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 216596011489 Metal-binding active site; metal-binding site 216596011490 Pfam match to entry PF01261.10 AP_endonuc_2 216596011491 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 216596011492 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 216596011493 putative NAD(P) binding site [chemical binding]; other site 216596011494 catalytic Zn binding site [ion binding]; other site 216596011495 structural Zn binding site [ion binding]; other site 216596011496 Pfam match to entry PF00107.10 ADH_zinc_N 216596011497 aminotransferase; Provisional; Region: PRK13356 216596011498 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 216596011499 homodimer interface [polypeptide binding]; other site 216596011500 substrate-cofactor binding pocket; other site 216596011501 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596011502 catalytic residue [active] 216596011503 Pfam match to entry PF01063.7 Aminotran_4 216596011504 transcriptional regulator; Provisional; Region: PRK10632 216596011505 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596011506 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 216596011507 putative effector binding pocket; other site 216596011508 dimerization interface [polypeptide binding]; other site 216596011509 Pfam match to entry PF03466.5 LysR_substrate 216596011510 Pfam match to entry PF00126.10 HTH_1 216596011511 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 216596011512 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 216596011513 HlyD family secretion protein; Region: HlyD_3; pfam13437 216596011514 1 probable transmembrane helix predicted at aa 64-86 216596011515 Pfam match to entry PF00529.8 HlyD 216596011516 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 216596011517 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596011518 putative substrate translocation pore; other site 216596011519 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596011520 13 probable transmembrane helices predicted at aa 29-51, 66-88, 95-117, 127-146,153-175, 185-204, 213-235, 250-269, 290-312, 322-344,351-368, 383-405 and 500-522 216596011521 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 216596011522 cyclase homology domain; Region: CHD; cd07302 216596011523 nucleotidyl binding site; other site 216596011524 metal binding site [ion binding]; metal-binding site 216596011525 dimer interface [polypeptide binding]; other site 216596011526 Pfam match to entry PF00211.9 Guanylate_cyc 216596011527 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 216596011528 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 216596011529 homodimer interface [polypeptide binding]; other site 216596011530 NAD binding pocket [chemical binding]; other site 216596011531 ATP binding pocket [chemical binding]; other site 216596011532 Mg binding site [ion binding]; other site 216596011533 active-site loop [active] 216596011534 Pfam match to entry PF02540.4 NAD_synthase 216596011535 glutathionine S-transferase; Provisional; Region: PRK10542 216596011536 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 216596011537 C-terminal domain interface [polypeptide binding]; other site 216596011538 GSH binding site (G-site) [chemical binding]; other site 216596011539 dimer interface [polypeptide binding]; other site 216596011540 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 216596011541 N-terminal domain interface [polypeptide binding]; other site 216596011542 dimer interface [polypeptide binding]; other site 216596011543 substrate binding pocket (H-site) [chemical binding]; other site 216596011544 Pfam match to entry PF00043.11 GST_C 216596011545 Pfam match to entry PF02798.6 GST_N 216596011546 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216596011547 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216596011548 Pfam match to entry PF00440.8 TetR_N 216596011549 drug efflux system protein MdtG; Provisional; Region: PRK09874 216596011550 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596011551 putative substrate translocation pore; other site 216596011552 Pfam match to entry PF00083.9 Sugar_tr 216596011553 12 probable transmembrane helices predicted at aa 120-142, 157-179, 191-210,215-237, 249-271, 276-298, 325-347, 360-382, 389-408,418-440, 452-474 and 478-500 216596011554 SnoaL-like domain; Region: SnoaL_2; pfam12680 216596011555 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 216596011556 8 probable transmembrane helices predicted at aa 7-29, 44-66, 73-93, 103-120,133-155, 170-192, 199-218 and 223-242 216596011557 Pfam match to entry PF01925.8 DUF81 216596011558 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596011559 S-adenosylmethionine binding site [chemical binding]; other site 216596011560 similarity:fasta; with=UniProt:Q8UH10_AGRT5 (EMBL:A97466); Agrobacterium tumefaciens (strain C58/ATCC 33970).; Hypothetical protein Atu0875 (AGR_C_1600p).; length=159; id 52.294; 109 aa overlap; query 22-128; subject 41-149 216596011561 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 216596011562 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 216596011563 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 216596011564 Pfam match to entry PF00081.9 Sod_Fe_N 216596011565 Pfam match to entry PF02777.5 Sod_Fe_C 216596011566 Homo sapiens Nbla03831 and related proteins, metallophosphatase domain; Region: MPP_Nbla03831; cd07396 216596011567 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 216596011568 active site 216596011569 metal binding site [ion binding]; metal-binding site 216596011570 Pfam match to entry PF00149.12 Metallophos 216596011571 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 216596011572 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216596011573 Pfam match to entry PF00165.8 HTH_AraC 216596011574 Pfam match to entry PF00165.8 HTH_AraC 216596011575 Pfam match to entry PF06719.1 AraC_N 216596011576 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 216596011577 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216596011578 NAD(P) binding site [chemical binding]; other site 216596011579 active site 216596011580 Pfam match to entry PF00106.11 adh_short 216596011581 Predicted transcriptional regulator [Transcription]; Region: COG2378 216596011582 HTH domain; Region: HTH_11; pfam08279 216596011583 WYL domain; Region: WYL; pfam13280 216596011584 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 216596011585 5 probable transmembrane helices predicted at aa 7-29, 44-66, 73-92, 145-167 and 186-208 216596011586 Pfam match to entry PF01810.7 LysE 216596011587 Cytochrome C' Region: Cytochrom_C_2; cl01610 216596011588 Pfam match to entry PF01322.9 Cytochrom_C_2 216596011589 Cytochrome c; Region: Cytochrom_C; pfam00034 216596011590 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 216596011591 Cytochrome c; Region: Cytochrom_C; cl11414 216596011592 1 probable transmembrane helix predicted at aa 5-27 216596011593 Pfam match to entry PF00034.8 Cytochrom_C 216596011594 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 216596011595 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 216596011596 putative C-terminal domain interface [polypeptide binding]; other site 216596011597 putative GSH binding site (G-site) [chemical binding]; other site 216596011598 putative dimer interface [polypeptide binding]; other site 216596011599 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 216596011600 N-terminal domain interface [polypeptide binding]; other site 216596011601 Pfam match to entry PF00043.11 GST_C 216596011602 Pfam match to entry PF02798.6 GST_N 216596011603 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216596011604 Coenzyme A binding pocket [chemical binding]; other site 216596011605 Pfam match to entry PF00583.9 Acetyltransf_1 216596011606 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 216596011607 putative metal binding site [ion binding]; other site 216596011608 putative homodimer interface [polypeptide binding]; other site 216596011609 putative homotetramer interface [polypeptide binding]; other site 216596011610 putative homodimer-homodimer interface [polypeptide binding]; other site 216596011611 putative allosteric switch controlling residues; other site 216596011612 Pfam match to entry PF02583.4 DUF156 216596011613 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 216596011614 Pfam match to entry PF01545.9 Cation_efflux 216596011615 6 probable transmembrane helices predicted at aa 50-72, 82-99, 119-141, 151-173,221-243 and 248-270 216596011616 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 216596011617 Pfam match to entry PF00144.9 Beta-lactamase 216596011618 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 216596011619 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 216596011620 Trp docking motif [polypeptide binding]; other site 216596011621 putative active site [active] 216596011622 Pfam match to entry PF01011.9 PQQ 216596011623 Pfam match to entry PF01011.9 PQQ 216596011624 Pfam match to entry PF01011.9 PQQ 216596011625 5 probable transmembrane helices predicted at aa 5-27, 31-48, 53-75, 80-99 and 111-133 216596011626 hypothetical protein; Validated; Region: PRK00029 216596011627 Uncharacterized conserved protein [Function unknown]; Region: COG0397 216596011628 Pfam match to entry PF02696.4 UPF0061 216596011629 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596011630 putative substrate translocation pore; other site 216596011631 14 probable transmembrane helices predicted at aa 11-33, 43-65, 77-99, 103-125,138-160, 164-186, 199-216, 226-243, 256-278, 288-310,331-348, 358-380, 401-423 and 433-452 216596011632 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 216596011633 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 216596011634 Pfam match to entry PF02574.5 S-methyl_trans 216596011635 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216596011636 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216596011637 Pfam match to entry PF00440.8 TetR_N 216596011638 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 216596011639 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 216596011640 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 216596011641 Pfam match to entry PF00326.7 Peptidase_S9 216596011642 Pfam match to entry PF02897.4 Peptidase_S9_N 216596011643 Domain of Unknown Function (DUF930); Region: DUF930; pfam06059 216596011644 Pfam match to entry PF06059.1 DUF930 216596011645 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 216596011646 Putative catalytic NodB homology domain of uncharacterized BH0857 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH0857_like; cd10955 216596011647 NodB motif; other site 216596011648 putative active site [active] 216596011649 putative catalytic site [active] 216596011650 Pfam match to entry PF01522.9 Polysacc_deac_1 216596011651 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 216596011652 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 216596011653 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 216596011654 Domain of unknown function DUF20; Region: UPF0118; pfam01594 216596011655 Pfam match to entry PF01594.6 UPF0118 216596011656 8 probable transmembrane helices predicted at aa 58-77, 81-100, 107-129, 198-220,247-269, 284-306, 313-335 and 355-377 216596011657 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 216596011658 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 216596011659 putative metal binding site [ion binding]; other site 216596011660 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 216596011661 active site 216596011662 metal binding site [ion binding]; metal-binding site 216596011663 Pfam match to entry PF00903.11 Glyoxalase 216596011664 Pfam match to entry PF00903.11 Glyoxalase 216596011665 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 216596011666 Ligand Binding Site [chemical binding]; other site 216596011667 Pfam match to entry PF00582.12 Usp 216596011668 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 216596011669 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 216596011670 Pfam match to entry PF03006.6 HlyIII 216596011671 7 probable transmembrane helices predicted at aa 24-46, 56-78, 91-108, 113-135,142-162, 167-189 and 196-218 216596011672 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 216596011673 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216596011674 Coenzyme A binding pocket [chemical binding]; other site 216596011675 Pfam match to entry PF00583.9 Acetyltransf_1 216596011676 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 216596011677 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 216596011678 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 216596011679 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 216596011680 Pfam match to entry PF00805.11 Pentapeptide 216596011681 Pfam match to entry PF00805.11 Pentapeptide 216596011682 Pfam match to entry PF00805.11 Pentapeptide 216596011683 methionine sulfoxide reductase B; Provisional; Region: PRK00222 216596011684 SelR domain; Region: SelR; pfam01641 216596011685 Pfam match to entry PF01641.7 SelR 216596011686 2 probable transmembrane helices predicted at aa 5-27 and 37-59 216596011687 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647 216596011688 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 216596011689 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 216596011690 19 probable transmembrane helices predicted at aa 4-26, 33-52, 82-104, 117-139,165-187, 208-230, 273-295, 302-319, 329-351, 372-394,409-431, 452-474, 502-524, 568-590, 605-624, 631-650,655-677, 689-711 and 749-768 216596011691 Pfam match to entry PF00361.7 Oxidored_q1 216596011692 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 216596011693 4 probable transmembrane helices predicted at aa 3-25, 35-57, 69-91 and 111-133 216596011694 Pfam match to entry PF04039.2 MnhB 216596011695 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12658 216596011696 Pfam match to entry PF00420.9 Oxidored_q2 216596011697 3 probable transmembrane helices predicted at aa 5-22, 29-51 and 73-95 216596011698 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 216596011699 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 216596011700 14 probable transmembrane helices predicted at aa 29-51, 60-82, 102-124, 137-154,158-180, 192-214, 234-256, 268-290, 300-321, 328-350,355-377, 397-419, 434-456 and 476-498 216596011701 Pfam match to entry PF00361.7 Oxidored_q1 216596011702 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 216596011703 1 probable transmembrane helix predicted at aa 10-32 216596011704 Pfam match to entry PF01899.6 MNHE 216596011705 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599 216596011706 3 probable transmembrane helices predicted at aa 5-27, 40-59 and 69-88 216596011707 Pfam match to entry PF04066.2 MrpF_PhaF 216596011708 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 216596011709 Pfam match to entry PF03334.3 PhaG_MnhG_YufB 216596011710 2 probable transmembrane helices predicted at aa 7-29 and 65-87 216596011711 Predicted transcriptional regulator [Transcription]; Region: COG4957 216596011712 Pfam match to entry PF05443.1 ROS_MUCR 216596011713 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 216596011714 Pfam match to entry PF02657.4 SufE 216596011715 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216596011716 dimer interface [polypeptide binding]; other site 216596011717 phosphorylation site [posttranslational modification] 216596011718 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596011719 ATP binding site [chemical binding]; other site 216596011720 Mg2+ binding site [ion binding]; other site 216596011721 G-X-G motif; other site 216596011722 2 probable transmembrane helices predicted at aa 52-74 and 81-103 216596011723 Pfam match to entry PF00512.10 HisKA 216596011724 Pfam match to entry PF02518.9 HATPase_c 216596011725 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 216596011726 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 216596011727 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 216596011728 2 probable transmembrane helices predicted at aa 21-43 and 58-80 216596011729 Pfam match to entry PF01471.6 PG_binding_1 216596011730 Cupin; Region: Cupin_6; pfam12852 216596011731 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216596011732 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216596011733 Pfam match to entry PF00165.8 HTH_AraC 216596011734 Pfam match to entry PF00165.8 HTH_AraC 216596011735 oxidoreductase; Provisional; Region: PRK06196 216596011736 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 216596011737 putative NAD(P) binding site [chemical binding]; other site 216596011738 active site 216596011739 Pfam match to entry PF00106.11 adh_short 216596011740 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216596011741 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 216596011742 dimer interface [polypeptide binding]; other site 216596011743 putative CheW interface [polypeptide binding]; other site 216596011744 Pfam match to entry PF00015.9 MCPsignal 216596011745 Protein of unknown function (DUF1491); Region: DUF1491; cl11568 216596011746 Pfam match to entry PF07372.1 DUF1491 216596011747 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330 216596011748 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 216596011749 Predicted integral membrane protein [Function unknown]; Region: COG5436 216596011750 1 probable transmembrane helix predicted at aa 4-26 216596011751 Uncharacterized conserved protein [Function unknown]; Region: COG5402 216596011752 Pfam match to entry PF06742.1 DUF1214 216596011753 Transglycosylase; Region: Transgly; pfam00912 216596011754 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 216596011755 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 216596011756 Pfam match to entry PF00905.8 Transpeptidase 216596011757 Pfam match to entry PF00912.8 Transgly 216596011758 hypothetical protein; Provisional; Region: PRK05170 216596011759 Pfam match to entry PF05779.2 DUF838 216596011760 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 216596011761 9 probable transmembrane helices predicted at aa 15-37, 50-72, 87-106, 113-135,139-160, 203-225, 240-262, 269-291 and 296-318 216596011762 Pfam match to entry PF03741.3 TerC 216596011763 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 216596011764 Pfam match to entry PF06055.1 ExoD 216596011765 4 probable transmembrane helices predicted at aa 30-52, 67-89, 136-158 and 178-200 216596011766 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216596011767 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216596011768 Pfam match to entry PF00440.8 TetR_N 216596011769 short chain dehydrogenase; Provisional; Region: PRK08303 216596011770 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216596011771 NAD(P) binding site [chemical binding]; other site 216596011772 active site 216596011773 Pfam match to entry PF00106.11 adh_short 216596011774 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 216596011775 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 216596011776 putative di-iron ligands [ion binding]; other site 216596011777 Pfam match to entry PF00487.11 FA_desaturase 216596011778 5 probable transmembrane helices predicted at aa 58-80, 85-107, 184-202, 217-239 and 244-266 216596011779 1 probable transmembrane helix predicted at aa 5-24 216596011780 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596011781 putative substrate translocation pore; other site 216596011782 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596011783 14 probable transmembrane helices predicted at aa 12-34, 49-71, 78-97, 112-134,141-163, 167-189, 202-224, 229-251, 271-293, 297-319,331-353, 363-385, 398-420 and 430-452 216596011784 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596011785 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596011786 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 216596011787 putative substrate binding pocket [chemical binding]; other site 216596011788 putative dimerization interface [polypeptide binding]; other site 216596011789 Pfam match to entry PF00126.10 HTH_1 216596011790 Pfam match to entry PF03466.5 LysR_substrate 216596011791 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 216596011792 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216596011793 Pfam match to entry PF00903.11 Glyoxalase 216596011794 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 216596011795 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 216596011796 Pfam match to entry PF01841.6 Transglut_core 216596011797 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 216596011798 oligomerisation interface [polypeptide binding]; other site 216596011799 mobile loop; other site 216596011800 roof hairpin; other site 216596011801 Pfam match to entry PF00166.8 Cpn10 216596011802 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 216596011803 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 216596011804 ring oligomerisation interface [polypeptide binding]; other site 216596011805 ATP/Mg binding site [chemical binding]; other site 216596011806 stacking interactions; other site 216596011807 hinge regions; other site 216596011808 Pfam match to entry PF00118.12 Cpn60_TCP1 216596011809 1 probable transmembrane helix predicted at aa 24-46 216596011810 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 216596011811 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 216596011812 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 216596011813 Pfam match to entry PF02894.4 GFO_IDH_MocA_C 216596011814 Pfam match to entry PF01408.8 GFO_IDH_MocA 216596011815 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 216596011816 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 216596011817 Pfam match to entry PF01261.10 AP_endonuc_2 216596011818 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 216596011819 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216596011820 DNA binding site [nucleotide binding] 216596011821 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 216596011822 putative ligand binding site [chemical binding]; other site 216596011823 Pfam match to entry PF00356.8 LacI 216596011824 Pfam match to entry PF00532.8 Peripla_BP_1 216596011825 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 216596011826 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 216596011827 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 216596011828 protein binding site [polypeptide binding]; other site 216596011829 Pfam match to entry PF00595.8 PDZ 216596011830 Cupin; Region: Cupin_6; pfam12852 216596011831 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216596011832 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216596011833 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216596011834 Pfam match to entry PF00165.8 HTH_AraC 216596011835 Pfam match to entry PF00165.8 HTH_AraC 216596011836 oxidoreductase; Provisional; Region: PRK06196 216596011837 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 216596011838 putative NAD(P) binding site [chemical binding]; other site 216596011839 active site 216596011840 Pfam match to entry PF00106.11 adh_short 216596011841 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 216596011842 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596011843 DNA-binding site [nucleotide binding]; DNA binding site 216596011844 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216596011845 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596011846 homodimer interface [polypeptide binding]; other site 216596011847 catalytic residue [active] 216596011848 Pfam match to entry PF00392.9 GntR 216596011849 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349 216596011850 Pfam match to entry PF06170.1 DUF983 216596011851 2 probable transmembrane helices predicted at aa 69-91 and 95-117 216596011852 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596011853 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596011854 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 216596011855 putative effector binding pocket; other site 216596011856 putative dimerization interface [polypeptide binding]; other site 216596011857 Pfam match to entry PF03466.5 LysR_substrate 216596011858 Pfam match to entry PF00126.10 HTH_1 216596011859 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 216596011860 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 216596011861 putative C-terminal domain interface [polypeptide binding]; other site 216596011862 putative GSH binding site (G-site) [chemical binding]; other site 216596011863 putative dimer interface [polypeptide binding]; other site 216596011864 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 216596011865 putative N-terminal domain interface [polypeptide binding]; other site 216596011866 putative dimer interface [polypeptide binding]; other site 216596011867 putative substrate binding pocket (H-site) [chemical binding]; other site 216596011868 Pfam match to entry PF02798.6 GST_N 216596011869 Pfam match to entry PF00043.11 GST_C 216596011870 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 216596011871 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 216596011872 Pfam match to entry PF01243.8 Pyridox_oxidase 216596011873 Pfam match to entry PF01243.8 Pyridox_oxidase 216596011874 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 216596011875 SnoaL-like domain; Region: SnoaL_2; pfam12680 216596011876 Pfam match to entry PF07080.1 DUF1348 216596011877 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216596011878 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216596011879 Pfam match to entry PF00440.8 TetR_N 216596011880 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 216596011881 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 216596011882 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216596011883 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596011884 putative substrate translocation pore; other site 216596011885 10 probable transmembrane helices predicted at aa 30-52, 67-89, 96-118, 122-144,151-173, 183-205, 234-256, 297-316, 323-345 and 389-411 216596011886 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 216596011887 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596011888 active site 216596011889 phosphorylation site [posttranslational modification] 216596011890 intermolecular recognition site; other site 216596011891 dimerization interface [polypeptide binding]; other site 216596011892 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216596011893 DNA binding site [nucleotide binding] 216596011894 Pfam match to entry PF00072.9 Response_reg 216596011895 Pfam match to entry PF00486.11 Trans_reg_C 216596011896 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 216596011897 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596011898 ATP binding site [chemical binding]; other site 216596011899 Mg2+ binding site [ion binding]; other site 216596011900 G-X-G motif; other site 216596011901 2 probable transmembrane helices predicted at aa 10-32 and 173-195 216596011902 Pfam match to entry PF00672.10 HAMP 216596011903 Pfam match to entry PF00512.10 HisKA 216596011904 Pfam match to entry PF02518.9 HATPase_c 216596011905 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 216596011906 Signal peptide predicted for RL1436 by SignalP 2.0 HMM (Signal peptide probabilty 0.955) with cleavage site probability 0.530 between residues 31 and 32 216596011907 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 216596011908 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 216596011909 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216596011910 TPR motif; other site 216596011911 binding surface 216596011912 2 probable transmembrane helices predicted at aa 4-26 and 98-115 216596011913 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 216596011914 Pfam match to entry PF03100.4 CcmE 216596011915 1 probable transmembrane helix predicted at aa 7-29 216596011916 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 216596011917 15 probable transmembrane helices predicted at aa 5-27, 40-62, 95-117, 124-143,175-197, 210-232, 247-264, 271-293, 308-330, 351-373,383-405, 425-442, 452-474, 494-516 and 613-635 216596011918 Pfam match to entry PF01578.9 Cytochrom_C_asm 216596011919 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 216596011920 Pfam match to entry PF03918.4 CcmH 216596011921 2 probable transmembrane helices predicted at aa 5-22 and 103-125 216596011922 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 216596011923 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 216596011924 protein binding site [polypeptide binding]; other site 216596011925 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 216596011926 Pfam match to entry PF00089.9 Trypsin 216596011927 Pfam match to entry PF00595.8 PDZ 216596011928 Pfam match to entry PF00595.8 PDZ 216596011929 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 216596011930 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596011931 active site 216596011932 phosphorylation site [posttranslational modification] 216596011933 intermolecular recognition site; other site 216596011934 dimerization interface [polypeptide binding]; other site 216596011935 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216596011936 DNA binding site [nucleotide binding] 216596011937 Pfam match to entry PF00072.9 Response_reg 216596011938 Pfam match to entry PF00486.11 Trans_reg_C 216596011939 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 216596011940 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 216596011941 dimerization interface [polypeptide binding]; other site 216596011942 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216596011943 dimer interface [polypeptide binding]; other site 216596011944 phosphorylation site [posttranslational modification] 216596011945 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596011946 ATP binding site [chemical binding]; other site 216596011947 Mg2+ binding site [ion binding]; other site 216596011948 G-X-G motif; other site 216596011949 2 probable transmembrane helices predicted at aa 15-37 and 167-186 216596011950 Pfam match to entry PF00672.10 HAMP 216596011951 Pfam match to entry PF00512.10 HisKA 216596011952 Pfam match to entry PF02518.9 HATPase_c 216596011953 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108 216596011954 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 216596011955 metal binding triad; other site 216596011956 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 216596011957 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 216596011958 metal binding triad; other site 216596011959 Pfam match to entry PF03710.3 GlnE 216596011960 Pfam match to entry PF03710.3 GlnE 216596011961 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 216596011962 putative C-terminal domain interface [polypeptide binding]; other site 216596011963 putative GSH binding site (G-site) [chemical binding]; other site 216596011964 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 216596011965 putative dimer interface [polypeptide binding]; other site 216596011966 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 216596011967 dimer interface [polypeptide binding]; other site 216596011968 N-terminal domain interface [polypeptide binding]; other site 216596011969 putative substrate binding pocket (H-site) [chemical binding]; other site 216596011970 Pfam match to entry PF02798.6 GST_N 216596011971 Pfam match to entry PF00043.11 GST_C 216596011972 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216596011973 PAS fold; Region: PAS_3; pfam08447 216596011974 putative active site [active] 216596011975 heme pocket [chemical binding]; other site 216596011976 PAS fold; Region: PAS_7; pfam12860 216596011977 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 216596011978 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216596011979 dimer interface [polypeptide binding]; other site 216596011980 phosphorylation site [posttranslational modification] 216596011981 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596011982 ATP binding site [chemical binding]; other site 216596011983 Mg2+ binding site [ion binding]; other site 216596011984 G-X-G motif; other site 216596011985 Pfam match to entry PF02518.9 HATPase_c 216596011986 Pfam match to entry PF00512.10 HisKA 216596011987 Pfam match to entry PF00785.11 PAC 216596011988 2 probable transmembrane helices predicted at aa 51-70 and 215-237 216596011989 aminopeptidase N; Provisional; Region: pepN; PRK14015 216596011990 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 216596011991 active site 216596011992 Zn binding site [ion binding]; other site 216596011993 Pfam match to entry PF01433.7 Peptidase_M1 216596011994 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 216596011995 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 216596011996 putative CheW interface [polypeptide binding]; other site 216596011997 Pfam match to entry PF00015.9 MCPsignal 216596011998 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 216596011999 EamA-like transporter family; Region: EamA; pfam00892 216596012000 EamA-like transporter family; Region: EamA; pfam00892 216596012001 10 probable transmembrane helices predicted at aa 12-29, 39-58, 79-98, 102-121,126-145, 160-179, 192-214, 219-241, 246-268 and 273-292 216596012002 Pfam match to entry PF00892.8 DUF6 216596012003 Pfam match to entry PF00892.8 DUF6 216596012004 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 216596012005 Fe-S cluster binding site [ion binding]; other site 216596012006 active site 216596012007 Pfam match to entry PF03167.6 UDG 216596012008 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 216596012009 putative chaperone; Provisional; Region: PRK11678 216596012010 nucleotide binding site [chemical binding]; other site 216596012011 putative NEF/HSP70 interaction site [polypeptide binding]; other site 216596012012 SBD interface [polypeptide binding]; other site 216596012013 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 216596012014 Pfam match to entry PF00873.7 ACR_tran 216596012015 11 probable transmembrane helices predicted at aa 15-37, 333-355, 359-381, 388-410,434-456, 463-485, 527-549, 853-875, 895-917, 952-974 and 984-1006 216596012016 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 216596012017 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 216596012018 HlyD family secretion protein; Region: HlyD_3; pfam13437 216596012019 Pfam match to entry PF00529.8 HlyD 216596012020 1 probable transmembrane helix predicted at aa 5-27 216596012021 Phosphotransferase enzyme family; Region: APH; pfam01636 216596012022 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 216596012023 active site 216596012024 ATP binding site [chemical binding]; other site 216596012025 Pfam match to entry PF01636.8 APH 216596012026 short chain dehydrogenase; Provisional; Region: PRK08339 216596012027 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 216596012028 putative NAD(P) binding site [chemical binding]; other site 216596012029 putative active site [active] 216596012030 Pfam match to entry PF00106.11 adh_short 216596012031 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 216596012032 hydroxyglutarate oxidase; Provisional; Region: PRK11728 216596012033 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 216596012034 Pfam match to entry PF05187.2 ETF_QO 216596012035 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 216596012036 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 216596012037 Pfam match to entry PF03734.4 ErfK_YbiS_YhnG 216596012038 10 probable transmembrane helices predicted at aa 13-35, 50-69, 76-98, 103-125,132-154, 158-180, 193-215, 225-247, 254-276 and 280-297 216596012039 Pfam match to entry PF00892.8 DUF6 216596012040 Pfam match to entry PF00892.8 DUF6 216596012041 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 216596012042 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216596012043 dimerization interface [polypeptide binding]; other site 216596012044 putative DNA binding site [nucleotide binding]; other site 216596012045 putative Zn2+ binding site [ion binding]; other site 216596012046 AsnC family; Region: AsnC_trans_reg; pfam01037 216596012047 Pfam match to entry PF01037.8 AsnC_trans_reg 216596012048 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 216596012049 MgtE intracellular N domain; Region: MgtE_N; pfam03448 216596012050 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 216596012051 Divalent cation transporter; Region: MgtE; pfam01769 216596012052 3 probable transmembrane helices predicted at aa 357-376, 395-417 and 432-454 216596012053 Pfam match to entry PF01769.6 MgtE 216596012054 Pfam match to entry PF00571.13 CBS 216596012055 Pfam match to entry PF00571.13 CBS 216596012056 Pfam match to entry PF03448.5 MgtE_N 216596012057 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 216596012058 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 216596012059 putative NAD(P) binding site [chemical binding]; other site 216596012060 dimer interface [polypeptide binding]; other site 216596012061 Pfam match to entry PF00107.10 ADH_zinc_N 216596012062 Predicted transcriptional regulators [Transcription]; Region: COG1733 216596012063 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 216596012064 Pfam match to entry PF01638.6 DUF24 216596012065 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 216596012066 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596012067 putative substrate translocation pore; other site 216596012068 Pfam match to entry PF00083.9 Sugar_tr 216596012069 12 probable transmembrane helices predicted at aa 62-84, 99-121, 128-150, 154-176,188-210, 215-237, 258-280, 295-317, 322-344, 348-367,388-407 and 411-433 216596012070 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 216596012071 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 216596012072 Pfam match to entry PF00781.9 DAGK_cat 216596012073 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 216596012074 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 216596012075 Pfam match to entry PF00120.9 Gln-synt_C 216596012076 putative aminotransferase; Validated; Region: PRK07480 216596012077 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 216596012078 inhibitor-cofactor binding pocket; inhibition site 216596012079 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596012080 catalytic residue [active] 216596012081 Pfam match to entry PF00202.8 Aminotran_3 216596012082 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 216596012083 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 216596012084 10 probable transmembrane helices predicted at aa 9-31, 69-91, 104-121, 131-148,153-175, 195-217, 248-270, 290-309, 316-335 and 345-367 216596012085 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 216596012086 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 216596012087 9 probable transmembrane helices predicted at aa 12-34, 69-91, 131-148, 163-185,197-219, 248-270, 291-310, 320-342 and 349-371 216596012088 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 216596012089 Ligand binding site; other site 216596012090 Putative Catalytic site; other site 216596012091 DXD motif; other site 216596012092 2 probable transmembrane helices predicted at aa 251-273 and 288-310 216596012093 Pfam match to entry PF00535.10 Glycos_transf_2 216596012094 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 216596012095 8 probable transmembrane helices predicted at aa 12-34, 57-79, 131-148, 163-185,197-216, 249-271, 292-309 and 346-368 216596012096 Pfam match to entry PF02366.7 PMT 216596012097 7 probable transmembrane helices predicted at aa 20-39, 49-67, 129-151, 156-175,220-242, 257-279 and 292-314 216596012098 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 216596012099 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 216596012100 DNA binding residues [nucleotide binding] 216596012101 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 216596012102 Pfam match to entry PF04542.2 Sigma70_r2 216596012103 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 216596012104 Pfam match to entry PF04946.2 DGPF 216596012105 YCII-related domain; Region: YCII; cl00999 216596012106 Pfam match to entry PF04946.2 DGPF 216596012107 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 216596012108 Pfam match to entry PF04946.2 DGPF 216596012109 1 probable transmembrane helix predicted at aa 57-79 216596012110 AMP nucleosidase; Provisional; Region: PRK08292 216596012111 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 216596012112 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 216596012113 Pfam match to entry PF01048.8 PNP_UDP_1 216596012114 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4731 216596012115 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 216596012116 Sel1 repeat; Region: Sel1; cl02723 216596012117 histidinol-phosphate aminotransferase; Provisional; Region: PRK08153 216596012118 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216596012119 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596012120 homodimer interface [polypeptide binding]; other site 216596012121 catalytic residue [active] 216596012122 Pfam match to entry PF00155.8 Aminotran_1_2 216596012123 Predicted membrane protein (DUF2177); Region: DUF2177; pfam09945 216596012124 4 probable transmembrane helices predicted at aa 29-51, 71-93, 100-122 and 132-154 216596012125 Protein required for attachment to host cells; Region: Host_attach; pfam10116 216596012126 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596012127 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216596012128 Pfam match to entry PF00126.10 HTH_1 216596012129 1 probable transmembrane helix predicted at aa 12-34 216596012130 replicative DNA helicase; Provisional; Region: PRK05973 216596012131 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 216596012132 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 216596012133 12 probable transmembrane helices predicted at aa 17-39, 54-76, 97-119, 139-161,168-190, 194-216, 239-261, 276-298, 319-341, 361-383,395-414 and 418-440 216596012134 Pfam match to entry PF01554.8 MatE 216596012135 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 216596012136 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216596012137 Pfam match to entry PF00165.8 HTH_AraC1 216596012138 Pfam match to entry PF00165.8 HTH_AraC 216596012139 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 216596012140 Pfam match to entry PF06568.1 DUF1127 216596012141 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 216596012142 Pfam match to entry PF06845.1 IolB 216596012143 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 216596012144 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 216596012145 Pfam match to entry PF06960.1 Myo-inos_cat_N 216596012146 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 216596012147 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 216596012148 dimer interface [polypeptide binding]; other site 216596012149 PYR/PP interface [polypeptide binding]; other site 216596012150 TPP binding site [chemical binding]; other site 216596012151 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 216596012152 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 216596012153 TPP-binding site; other site 216596012154 Pfam match to entry PF00205.10 TPP_enzyme_M 216596012155 Pfam match to entry PF02776.6 TPP_enzyme_N 216596012156 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 216596012157 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 216596012158 substrate binding site [chemical binding]; other site 216596012159 ATP binding site [chemical binding]; other site 216596012160 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 216596012161 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 216596012162 Pfam match to entry PF00294.10 PfkB 216596012163 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 216596012164 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 216596012165 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 216596012166 putative active site [active] 216596012167 Pfam match to entry PF01380.9 SIS 216596012168 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 216596012169 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 216596012170 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 216596012171 Pfam match to entry PF01408.8 GFO_IDH_MocA 216596012172 Pfam match to entry PF02894.4 GFO_IDH_MocA_C 216596012173 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 216596012174 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 216596012175 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 216596012176 Pfam match to entry PF00070.12 Pyr_redox 216596012177 Porin subfamily; Region: Porin_2; pfam02530 216596012178 Pfam match to entry PF02530.4 Porin_2 216596012179 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216596012180 Pfam match to entry PF00561.8 Abhydrolase_1 216596012181 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 216596012182 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 216596012183 N-acetyl-D-glucosamine binding site [chemical binding]; other site 216596012184 catalytic residue [active] 216596012185 Pfam match to entry PF01464.7 SLT 216596012186 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 216596012187 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 216596012188 dimer interface [polypeptide binding]; other site 216596012189 active site 216596012190 catalytic residue [active] 216596012191 Pfam match to entry PF00701.10 DHDPS 216596012192 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 216596012193 SmpB-tmRNA interface; other site 216596012194 Pfam match to entry PF01668.6 SmpB 216596012195 Uncharacterized conserved protein [Function unknown]; Region: COG1432 216596012196 LabA_like proteins; Region: LabA; cd10911 216596012197 putative metal binding site [ion binding]; other site 216596012198 Pfam match to entry PF01936.8 DUF88 216596012199 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 216596012200 Pfam match to entry PF01192.10 RNA_pol_Rpb6 216596012201 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 216596012202 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 216596012203 Zn2+ binding site [ion binding]; other site 216596012204 Mg2+ binding site [ion binding]; other site 216596012205 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 216596012206 synthetase active site [active] 216596012207 NTP binding site [chemical binding]; other site 216596012208 metal binding site [ion binding]; metal-binding site 216596012209 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 216596012210 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 216596012211 Pfam match to entry PF01966.8 HD 216596012212 Pfam match to entry PF04607.3 RelA_SpoT 216596012213 Pfam match to entry PF02824.6 TGS 216596012214 Pfam match to entry PF01842.8 ACT 216596012215 Protein of unknown function (DUF3563); Region: DUF3563; pfam12086 216596012216 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3216 216596012217 4 probable transmembrane helices predicted at aa 36-58, 62-84, 89-111 and 145-167 216596012218 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 216596012219 Pfam match to entry PF01648.8 ACPS 216596012220 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 216596012221 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 216596012222 Catalytic site [active] 216596012223 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 216596012224 1 probable transmembrane helix predicted at aa 12-34 216596012225 Pfam match to entry PF00717.8 Peptidase_S24 216596012226 ribonuclease III; Reviewed; Region: PRK12371 216596012227 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 216596012228 dimerization interface [polypeptide binding]; other site 216596012229 active site 216596012230 metal binding site [ion binding]; metal-binding site 216596012231 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 216596012232 dsRNA binding site [nucleotide binding]; other site 216596012233 Pfam match to entry PF00636.10 Ribonuclease_3 216596012234 Pfam match to entry PF00035.10 dsrm 216596012235 GTPase Era; Reviewed; Region: era; PRK00089 216596012236 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 216596012237 G1 box; other site 216596012238 GTP/Mg2+ binding site [chemical binding]; other site 216596012239 Switch I region; other site 216596012240 G2 box; other site 216596012241 Switch II region; other site 216596012242 G3 box; other site 216596012243 G4 box; other site 216596012244 G5 box; other site 216596012245 KH domain; Region: KH_2; pfam07650 216596012246 Pfam match to entry PF07650.1 KH_2 216596012247 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 216596012248 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 216596012249 ligand binding site [chemical binding]; other site 216596012250 flexible hinge region; other site 216596012251 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 216596012252 putative switch regulator; other site 216596012253 non-specific DNA interactions [nucleotide binding]; other site 216596012254 DNA binding site [nucleotide binding] 216596012255 sequence specific DNA binding site [nucleotide binding]; other site 216596012256 putative cAMP binding site [chemical binding]; other site 216596012257 Pfam match to entry PF00027.13 cNMP_binding 216596012258 Pfam match to entry PF00325.9 Crp 216596012259 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596012260 active site 216596012261 phosphorylation site [posttranslational modification] 216596012262 intermolecular recognition site; other site 216596012263 dimerization interface [polypeptide binding]; other site 216596012264 Pfam match to entry PF00072.9 Response_reg 216596012265 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 216596012266 Recombination protein O N terminal; Region: RecO_N; pfam11967 216596012267 Recombination protein O C terminal; Region: RecO_C; pfam02565 216596012268 Pfam match to entry PF02565.4 RecO 216596012269 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 216596012270 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 216596012271 active site 216596012272 catalytic tetrad [active] 216596012273 Pfam match to entry PF00248.9 Aldo_ket_red 216596012274 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 216596012275 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 216596012276 MOSC domain; Region: MOSC; pfam03473 216596012277 Pfam match to entry PF03473.5 MOSC 216596012278 Pfam match to entry PF03476.3 MOSC_N 216596012279 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 216596012280 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 216596012281 Pfam match to entry PF01966.8 HD 216596012282 PAS domain; Region: PAS; smart00091 216596012283 PAS fold; Region: PAS_7; pfam12860 216596012284 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 216596012285 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216596012286 metal binding site [ion binding]; metal-binding site 216596012287 active site 216596012288 I-site; other site 216596012289 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216596012290 Pfam match to entry PF00563.9 EAL 216596012291 Pfam match to entry PF00990.8 GGDEF 216596012292 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 216596012293 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 216596012294 E-class dimer interface [polypeptide binding]; other site 216596012295 P-class dimer interface [polypeptide binding]; other site 216596012296 active site 216596012297 Cu2+ binding site [ion binding]; other site 216596012298 Zn2+ binding site [ion binding]; other site 216596012299 Pfam match to entry PF00080.8 Sod_Cu 216596012300 Mechanosensitive ion channel; Region: MS_channel; pfam00924 216596012301 Pfam match to entry PF00924.8 MS_channel 216596012302 3 probable transmembrane helices predicted at aa 22-44, 64-86 and 93-115 216596012303 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 216596012304 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 216596012305 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 216596012306 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 216596012307 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 216596012308 Pfam match to entry PF01571.8 GCV_T 216596012309 1 probable transmembrane helix predicted at aa 20-42 216596012310 Protein of unknown function (DUF2385); Region: DUF2385; pfam09539 216596012311 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 216596012312 nudix motif; other site 216596012313 Pfam match to entry PF00293.12 NUDIX 216596012314 Uncharacterized conserved protein [Function unknown]; Region: COG1742 216596012315 Pfam match to entry PF02694.4 UPF0060 216596012316 4 probable transmembrane helices predicted at aa 2-24, 29-51, 58-77 and 87-104 216596012317 Uncharacterized conserved protein [Function unknown]; Region: COG2135 216596012318 Pfam match to entry PF02586.4 DUF159 216596012319 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 216596012320 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 216596012321 CDP-alcohol phosphatidyltransferase 2; Region: CDP-OH_P_tran_2; pfam08009 216596012322 6 probable transmembrane helices predicted at aa 33-55, 96-115, 120-142, 157-179,186-208 and 223-255 216596012323 Pfam match to entry PF01066.9 CDP-OH_P_transf 216596012324 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 216596012325 Pfam match to entry PF02666.4 PS_Dcarbxylase 216596012326 1 probable transmembrane helix predicted at aa 67-89 216596012327 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 216596012328 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 216596012329 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 216596012330 Walker A/P-loop; other site 216596012331 ATP binding site [chemical binding]; other site 216596012332 Q-loop/lid; other site 216596012333 ABC transporter signature motif; other site 216596012334 Walker B; other site 216596012335 D-loop; other site 216596012336 H-loop/switch region; other site 216596012337 Pfam match to entry PF00005.11 ABC_tran 216596012338 5 probable transmembrane helices predicted at aa 82-104, 119-141, 223-245, 315-337 and 349-371 216596012339 Pfam match to entry PF00664.9 ABC_membrane 216596012340 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 216596012341 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 216596012342 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 216596012343 Pfam match to entry PF01476.8 LysM 216596012344 1 probable transmembrane helix predicted at aa 7-26 216596012345 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 216596012346 Pfam match to entry PF03641.3 Lysine_decarbox 216596012347 Predicted permeases [General function prediction only]; Region: RarD; COG2962 216596012348 10 probable transmembrane helices predicted at aa 21-40, 55-72, 85-107, 117-134,141-158, 162-179, 191-213, 223-245, 252-274 and 279-301 216596012349 Pfam match to entry PF00892.8 DUF6 216596012350 Pfam match to entry PF00892.8 DUF6 216596012351 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 216596012352 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 216596012353 active site 216596012354 catalytic residues [active] 216596012355 metal binding site [ion binding]; metal-binding site 216596012356 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 216596012357 Pfam match to entry PF00682.8 HMGL-like 216596012358 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 216596012359 Pfam match to entry PF00561.8 Abhydrolase_1 216596012360 Uncharacterized conserved protein [Function unknown]; Region: COG3791 216596012361 Pfam match to entry PF04828.3 DUF636 216596012362 Uncharacterized conserved protein [Function unknown]; Region: COG3791 216596012363 Pfam match to entry PF04828.3 DUF636 216596012364 Uncharacterized conserved protein [Function unknown]; Region: COG3791 216596012365 Pfam match to entry PF04828.3 DUF636 216596012366 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 216596012367 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 216596012368 active site 216596012369 HIGH motif; other site 216596012370 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 216596012371 KMSKS motif; other site 216596012372 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 216596012373 Pfam match to entry PF01406.8 tRNA-synt_1e 216596012374 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 216596012375 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 216596012376 active site 216596012377 1 probable transmembrane helix predicted at aa 7-29 216596012378 Pfam match to entry PF01183.9 Glyco_hydro_25 216596012379 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 216596012380 classical (c) SDRs; Region: SDR_c; cd05233 216596012381 NAD(P) binding site [chemical binding]; other site 216596012382 active site 216596012383 Pfam match to entry PF00106.11 adh_short 216596012384 amidophosphoribosyltransferase; Provisional; Region: PRK09123 216596012385 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 216596012386 active site 216596012387 tetramer interface [polypeptide binding]; other site 216596012388 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 216596012389 active site 216596012390 Pfam match to entry PF00156.11 Pribosyltran 216596012391 Pfam match to entry PF00310.9 GATase_2 216596012392 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 216596012393 Colicin V production protein; Region: Colicin_V; pfam02674 216596012394 Pfam match to entry PF02674.5 Colicin_V 216596012395 4 probable transmembrane helices predicted at aa 5-27, 32-51, 63-85 and 105-127 216596012396 DNA repair protein RadA; Provisional; Region: PRK11823 216596012397 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 216596012398 Walker A motif; other site 216596012399 ATP binding site [chemical binding]; other site 216596012400 Walker B motif; other site 216596012401 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 216596012402 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 216596012403 6 probable transmembrane helices predicted at aa 10-32, 41-63, 67-89, 120-142,152-174 and 187-209 216596012404 Pfam match to entry PF01810.7 LysE 216596012405 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 216596012406 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 216596012407 active site 216596012408 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 216596012409 dimer interface [polypeptide binding]; other site 216596012410 substrate binding site [chemical binding]; other site 216596012411 catalytic residues [active] 216596012412 Pfam match to entry PF00842.8 Ala_racemase_C 216596012413 Pfam match to entry PF01168.8 Ala_racemase_N 216596012414 replicative DNA helicase; Provisional; Region: PRK09165 216596012415 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 216596012416 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 216596012417 Walker A motif; other site 216596012418 ATP binding site [chemical binding]; other site 216596012419 Walker B motif; other site 216596012420 DNA binding loops [nucleotide binding] 216596012421 Pfam match to entry PF03796.3 DnaB_C 216596012422 Pfam match to entry PF00772.9 DnaB 216596012423 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 216596012424 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 216596012425 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 216596012426 Pfam match to entry PF03948.3 Ribosomal_L9_C 216596012427 Pfam match to entry PF01281.8 Ribosomal_L9_N 216596012428 7 probable transmembrane helices predicted at aa 9-28, 32-54, 61-83, 119-141,176-198, 228-261 and 281-303 216596012429 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 216596012430 Pfam match to entry PF01084.7 Ribosomal_S18 216596012431 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 216596012432 Pfam match to entry PF01250.7 Ribosomal_S6 216596012433 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 216596012434 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 216596012435 active site 216596012436 catalytic tetrad [active] 216596012437 Pfam match to entry PF00248.9 Aldo_ket_red 216596012438 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 216596012439 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 216596012440 Pfam match to entry PF00698.9 Acyl_transf_1 216596012441 3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936 216596012442 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 216596012443 NAD(P) binding site [chemical binding]; other site 216596012444 homotetramer interface [polypeptide binding]; other site 216596012445 homodimer interface [polypeptide binding]; other site 216596012446 active site 216596012447 Pfam match to entry PF00106.11 adh_short 216596012448 acyl carrier protein; Provisional; Region: acpP; PRK00982 216596012449 Pfam match to entry PF00550.9 PP-binding 216596012450 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 216596012451 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 216596012452 dimer interface [polypeptide binding]; other site 216596012453 active site 216596012454 Pfam match to entry PF00109.11 ketoacyl-synt 216596012455 Pfam match to entry PF02801.7 Ketoacyl-synt_C 216596012456 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 216596012457 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 216596012458 dimerization interface [polypeptide binding]; other site 216596012459 1 probable transmembrane helix predicted at aa 47-69 216596012460 Pfam match to entry PF02618.4 ADC_lyase 216596012461 Uncharacterized stress-induced protein [Function unknown]; Region: COG1561 216596012462 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 216596012463 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 216596012464 Pfam match to entry PF03755.3 YicC_N 216596012465 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 216596012466 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 216596012467 catalytic site [active] 216596012468 G-X2-G-X-G-K; other site 216596012469 Pfam match to entry PF00625.8 Guanylate_kin 216596012470 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 216596012471 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596012472 S-adenosylmethionine binding site [chemical binding]; other site 216596012473 Pfam match to entry PF00398.8 RrnaAD 216596012474 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312 216596012475 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 216596012476 Pfam match to entry PF04166.2 PdxA 216596012477 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 216596012478 SurA N-terminal domain; Region: SurA_N; pfam09312 216596012479 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 216596012480 Organic solvent tolerance protein; Region: OstA_C; pfam04453 216596012481 Pfam match to entry PF04453.3 OstA_C 216596012482 1 probable transmembrane helix predicted at aa 13-35 216596012483 Predicted permeases [General function prediction only]; Region: COG0795 216596012484 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 216596012485 Pfam match to entry PF03739.3 YjgP_YjgQ 216596012486 6 probable transmembrane helices predicted at aa 13-32, 62-84, 97-119, 278-300,307-329 and 339-358 216596012487 Predicted permeases [General function prediction only]; Region: COG0795 216596012488 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 216596012489 Pfam match to entry PF03739.3 YjgP_YjgQ 216596012490 6 probable transmembrane helices predicted at aa 20-42, 62-84, 108-127, 286-304,317-334 and 344-366 216596012491 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 216596012492 active site 216596012493 Pfam match to entry PF01569.9 PAP2 216596012494 6 probable transmembrane helices predicted at aa 21-43, 85-102, 122-139, 175-194,201-218 and 228-245 216596012495 multifunctional aminopeptidase A; Provisional; Region: PRK00913 216596012496 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 216596012497 interface (dimer of trimers) [polypeptide binding]; other site 216596012498 Substrate-binding/catalytic site; other site 216596012499 Zn-binding sites [ion binding]; other site 216596012500 Pfam match to entry PF02789.4 Peptidase_M17_N 216596012501 Pfam match to entry PF00883.9 Peptidase_M17 216596012502 DNA polymerase III subunit chi; Validated; Region: PRK05728 216596012503 Pfam match to entry PF04364.2 DNA_pol3_chi 216596012504 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 216596012505 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 216596012506 Pfam match to entry PF01408.8 GFO_IDH_MocA 216596012507 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 216596012508 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 216596012509 Pfam match to entry PF00326.7 Peptidase_S9 216596012510 Pfam match to entry PF02897.4 Peptidase_S9_N 216596012511 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 216596012512 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 216596012513 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 216596012514 ABC transporter; Region: ABC_tran_2; pfam12848 216596012515 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 216596012516 Pfam match to entry PF00005.11 ABC_tran 216596012517 Pfam match to entry PF00005.11 ABC_tran 216596012518 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 216596012519 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216596012520 metal binding site [ion binding]; metal-binding site 216596012521 active site 216596012522 I-site; other site 216596012523 Pfam match to entry PF00990.8 GGDEF 216596012524 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 216596012525 DinB superfamily; Region: DinB_2; pfam12867 216596012526 Pfam match to entry PF05163.2 DinB 216596012527 GST_N family, Beta etherase LigE subfamily; composed of proteins similar to Sphingomonas paucimobilis beta etherase, LigE, a GST-like protein that catalyzes the cleavage of the beta-aryl ether linkages present in low-moleculer weight lignins using GSH as...; Region: GST_N_etherase_LigE; cd03038 216596012528 glutaredoxin 2; Provisional; Region: PRK10387 216596012529 putative C-terminal domain interface [polypeptide binding]; other site 216596012530 putative GSH binding site (G-site) [chemical binding]; other site 216596012531 putative dimer interface [polypeptide binding]; other site 216596012532 C-terminal, alpha helical domain of Beta etherase LigE; Region: GST_C_etherase_LigE; cd03202 216596012533 putative N-terminal domain interface [polypeptide binding]; other site 216596012534 putative dimer interface [polypeptide binding]; other site 216596012535 putative substrate binding pocket (H-site) [chemical binding]; other site 216596012536 Pfam match to entry PF00043.11 GST_C 216596012537 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 216596012538 active site 216596012539 multimer interface [polypeptide binding]; other site 216596012540 Pfam match to entry PF00334.7 NDK 216596012541 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 216596012542 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 216596012543 CGNR zinc finger; Region: zf-CGNR; pfam11706 216596012544 Pfam match to entry PF07336.1 DUF1470 216596012545 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 216596012546 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596012547 TM-ABC transporter signature motif; other site 216596012548 Pfam match to entry PF02653.5 BPD_transp_2 216596012549 7 probable transmembrane helices predicted at aa 10-32, 39-61, 65-87, 100-122,149-171, 201-223 and 273-290 216596012550 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 216596012551 MoaE homodimer interface [polypeptide binding]; other site 216596012552 MoaD interaction [polypeptide binding]; other site 216596012553 active site residues [active] 216596012554 Pfam match to entry PF02391.5 MoaE 216596012555 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 216596012556 MoaE interaction surface [polypeptide binding]; other site 216596012557 MoeB interaction surface [polypeptide binding]; other site 216596012558 thiocarboxylated glycine; other site 216596012559 Pfam match to entry PF02597.6 ThiS 216596012560 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 216596012561 Pfam match to entry PF01066.9 CDP-OH_P_transf 216596012562 4 probable transmembrane helices predicted at aa 12-31, 41-60, 81-103 and 157-179 216596012563 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 216596012564 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 216596012565 GIY-YIG motif/motif A; other site 216596012566 active site 216596012567 catalytic site [active] 216596012568 putative DNA binding site [nucleotide binding]; other site 216596012569 metal binding site [ion binding]; metal-binding site 216596012570 UvrB/uvrC motif; Region: UVR; pfam02151 216596012571 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 216596012572 Pfam match to entry PF00633.11 HHH 216596012573 Pfam match to entry PF00633.11 HHH 216596012574 Pfam match to entry PF02151.6 UVR 216596012575 Pfam match to entry PF01541.11 GIY-YIG 216596012576 short chain dehydrogenase; Provisional; Region: PRK09134 216596012577 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216596012578 NAD(P) binding site [chemical binding]; other site 216596012579 active site 216596012580 Pfam match to entry PF00106.11 adh_short 216596012581 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 216596012582 Pfam match to entry PF01389.7 OmpA_membrane 216596012583 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 216596012584 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 216596012585 putative C-terminal domain interface [polypeptide binding]; other site 216596012586 putative GSH binding site (G-site) [chemical binding]; other site 216596012587 putative dimer interface [polypeptide binding]; other site 216596012588 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 216596012589 dimer interface [polypeptide binding]; other site 216596012590 N-terminal domain interface [polypeptide binding]; other site 216596012591 putative substrate binding pocket (H-site) [chemical binding]; other site 216596012592 Pfam match to entry PF02798.6 GST_N 216596012593 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 216596012594 Pfam match to entry PF04378.2 DUF519 216596012595 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 216596012596 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 216596012597 putative [4Fe-4S] binding site [ion binding]; other site 216596012598 putative molybdopterin cofactor binding site [chemical binding]; other site 216596012599 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 216596012600 putative molybdopterin cofactor binding site; other site 216596012601 Pfam match to entry PF04879.3 Molybdop_Fe4S4 216596012602 Pfam match to entry PF00384.9 Molybdopterin 216596012603 Pfam match to entry PF01568.7 Molydop_binding 216596012604 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 216596012605 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 216596012606 dimer interface [polypeptide binding]; other site 216596012607 ADP-ribose binding site [chemical binding]; other site 216596012608 active site 216596012609 nudix motif; other site 216596012610 metal binding site [ion binding]; metal-binding site 216596012611 Pfam match to entry PF00293.12 NUDIX 216596012612 phosphonate metabolism protein PhnM; Region: phosphono_phnM; TIGR02318 216596012613 Amidohydrolase; Region: Amidohydro_5; pfam13594 216596012614 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 216596012615 active site 216596012616 Pfam match to entry PF01979.7 Amidohydro_1 216596012617 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 216596012618 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 216596012619 active site 216596012620 substrate binding site [chemical binding]; other site 216596012621 cosubstrate binding site; other site 216596012622 catalytic site [active] 216596012623 Pfam match to entry PF00551.8 Formyl_trans_N 216596012624 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 216596012625 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 216596012626 dimerization interface [polypeptide binding]; other site 216596012627 putative ATP binding site [chemical binding]; other site 216596012628 Pfam match to entry PF02769.9 AIRS_C 216596012629 Pfam match to entry PF00586.11 AIRS 216596012630 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 216596012631 Domain of unknown function DUF20; Region: UPF0118; pfam01594 216596012632 Pfam match to entry PF01594.6 UPF0118 216596012633 8 probable transmembrane helices predicted at aa 13-47, 67-89, 133-152, 157-177,219-241, 251-273, 278-297 and 312-343 216596012634 hypothetical protein; Validated; Region: PRK09087 216596012635 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 216596012636 polyphosphate kinase; Provisional; Region: PRK05443 216596012637 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 216596012638 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 216596012639 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 216596012640 putative domain interface [polypeptide binding]; other site 216596012641 putative active site [active] 216596012642 catalytic site [active] 216596012643 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 216596012644 putative domain interface [polypeptide binding]; other site 216596012645 putative active site [active] 216596012646 catalytic site [active] 216596012647 Pfam match to entry PF02503.6 PP_kinase 216596012648 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 216596012649 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 216596012650 Pfam match to entry PF02541.4 Ppx-GppA 216596012651 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 216596012652 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 216596012653 cyclase homology domain; Region: CHD; cd07302 216596012654 nucleotidyl binding site; other site 216596012655 metal binding site [ion binding]; metal-binding site 216596012656 dimer interface [polypeptide binding]; other site 216596012657 Pfam match to entry PF00211.9 Guanylate_cyc 216596012658 4 probable transmembrane helices predicted at aa 21-40, 45-67, 88-110 and 120-142 216596012659 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 216596012660 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 216596012661 catalytic site [active] 216596012662 putative active site [active] 216596012663 putative substrate binding site [chemical binding]; other site 216596012664 HRDC domain; Region: HRDC; pfam00570 216596012665 Pfam match to entry PF00570.11 HRDC 216596012666 Pfam match to entry PF01612.10 3_5_exonuc 216596012667 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 216596012668 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 216596012669 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 216596012670 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 216596012671 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 216596012672 dimer interface [polypeptide binding]; other site 216596012673 anticodon binding site; other site 216596012674 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 216596012675 homodimer interface [polypeptide binding]; other site 216596012676 motif 1; other site 216596012677 active site 216596012678 motif 2; other site 216596012679 GAD domain; Region: GAD; pfam02938 216596012680 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 216596012681 active site 216596012682 motif 3; other site 216596012683 Pfam match to entry PF01336.9 tRNA_anti 216596012684 Pfam match to entry PF00152.8 tRNA-synt_2 216596012685 Pfam match to entry PF02938.4 GAD 216596012686 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 216596012687 Beta-lactamase; Region: Beta-lactamase; pfam00144 216596012688 Pfam match to entry PF00144.9 Beta-lactamase 216596012689 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216596012690 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216596012691 Pfam match to entry PF00440.8 TetR_N 216596012692 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 216596012693 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 216596012694 CAP-like domain; other site 216596012695 active site 216596012696 primary dimer interface [polypeptide binding]; other site 216596012697 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 216596012698 Pfam match to entry PF00521.7 DNA_topoisoIV 216596012699 Pfam match to entry PF03989.2 DNA_gyraseA_C 216596012700 Pfam match to entry PF03989.2 DNA_gyraseA_C 216596012701 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 216596012702 putative hydrophobic ligand binding site [chemical binding]; other site 216596012703 Pfam match to entry PF05146.3 DUF704 216596012704 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 216596012705 Pfam match to entry PF05012.2 DOC 216596012706 putative addiction module antidote; Region: doc_partner; TIGR02609 216596012707 Pfam match to entry PF04014.4 SpoVT_AbrB 216596012708 EamA-like transporter family; Region: EamA; pfam00892 216596012709 Pfam match to entry PF00892 DUF6 216596012710 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 216596012711 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 216596012712 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 216596012713 Pfam match to entry PF04377.3 ATE_C 216596012714 Pfam match to entry PF04376.2 ATE_N 216596012715 Predicted membrane protein/domain [Function unknown]; Region: COG1714 216596012716 Pfam match to entry PF06271.1 RDD 216596012717 3 probable transmembrane helices predicted at aa 28-50, 57-79 and 109-131 216596012718 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 216596012719 dimer interface [polypeptide binding]; other site 216596012720 allosteric magnesium binding site [ion binding]; other site 216596012721 active site 216596012722 aspartate-rich active site metal binding site; other site 216596012723 Schiff base residues; other site 216596012724 Pfam match to entry PF00490.9 ALAD 216596012725 4 probable transmembrane helices predicted at aa 72-94, 109-131, 138-160 and 164-183 216596012726 Transcriptional regulators [Transcription]; Region: MarR; COG1846 216596012727 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 216596012728 Pfam match to entry PF01047.8 MarR 216596012729 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 216596012730 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 216596012731 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 216596012732 Pfam match to entry PF01471 PG_binding_1 216596012733 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 216596012734 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 216596012735 dimer interface [polypeptide binding]; other site 216596012736 active site 216596012737 glycine-pyridoxal phosphate binding site [chemical binding]; other site 216596012738 folate binding site [chemical binding]; other site 216596012739 Pfam match to entry PF00464.8 SHMT 216596012740 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 216596012741 catalytic motif [active] 216596012742 Zn binding site [ion binding]; other site 216596012743 RibD C-terminal domain; Region: RibD_C; cl17279 216596012744 RibD C-terminal domain; Region: RibD_C; cl17279 216596012745 Pfam match to entry PF00383.9 dCMP_cyt_deam 216596012746 Pfam match to entry PF01872.7 RibD_C 216596012747 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 216596012748 Lumazine binding domain; Region: Lum_binding; pfam00677 216596012749 Lumazine binding domain; Region: Lum_binding; pfam00677 216596012750 Pfam match to entry PF00677.7 Lum_binding 216596012751 Pfam match to entry PF00677.7 Lum_binding 216596012752 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 216596012753 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 216596012754 substrate binding site; other site 216596012755 tetramer interface; other site 216596012756 Pfam match to entry PF00483.9 NTP_transferase 216596012757 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 216596012758 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 216596012759 NADP binding site [chemical binding]; other site 216596012760 active site 216596012761 putative substrate binding site [chemical binding]; other site 216596012762 Pfam match to entry PF04321.4 RmlD_sub_bind 216596012763 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 216596012764 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 216596012765 NAD binding site [chemical binding]; other site 216596012766 substrate binding site [chemical binding]; other site 216596012767 homodimer interface [polypeptide binding]; other site 216596012768 active site 216596012769 Pfam match to entry PF01370.8 Epimerase 216596012770 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 216596012771 Pfam match to entry PF00908.7 dTDP_sugar_isom 216596012772 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 216596012773 Cupin domain; Region: Cupin_2; cl17218 216596012774 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 216596012775 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 216596012776 homopentamer interface [polypeptide binding]; other site 216596012777 active site 216596012778 Pfam match to entry PF00885.7 DMRL_synthase 216596012779 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 216596012780 putative RNA binding site [nucleotide binding]; other site 216596012781 Pfam match to entry PF01029.8 NusB 216596012782 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; COG3808 216596012783 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 216596012784 Pfam match to entry PF03030.5 H_PPase 216596012785 15 probable transmembrane helices predicted at aa 41-60, 96-113, 117-139, 170-192,202-224, 275-297, 302-324, 337-359, 369-391, 446-468,512-531, 561-583, 628-650, 657-679 and 728-750 216596012786 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 216596012787 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 216596012788 Pfam match to entry PF04355.2 SmpA_OmlA 216596012789 Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; cl12045 216596012790 Pfam match to entry PF03981.2 Ubiq_cyt_C_chap 216596012791 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 216596012792 putative phosphate acyltransferase; Provisional; Region: PRK05331 216596012793 Pfam match to entry PF02504.4 FA_synthesis 216596012794 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 216596012795 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 216596012796 dimer interface [polypeptide binding]; other site 216596012797 active site 216596012798 CoA binding pocket [chemical binding]; other site 216596012799 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 216596012800 IHF dimer interface [polypeptide binding]; other site 216596012801 IHF - DNA interface [nucleotide binding]; other site 216596012802 Pfam match to entry PF00216.8 Bac_DNA_binding 216596012803 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 216596012804 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 216596012805 DNA binding residues [nucleotide binding] 216596012806 Pfam match to entry PF00376.9 MerR 216596012807 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 216596012808 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596012809 active site 216596012810 phosphorylation site [posttranslational modification] 216596012811 intermolecular recognition site; other site 216596012812 dimerization interface [polypeptide binding]; other site 216596012813 Pfam match to entry PF00072.9 Response_reg 216596012814 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 216596012815 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 216596012816 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216596012817 dimer interface [polypeptide binding]; other site 216596012818 phosphorylation site [posttranslational modification] 216596012819 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596012820 ATP binding site [chemical binding]; other site 216596012821 Mg2+ binding site [ion binding]; other site 216596012822 G-X-G motif; other site 216596012823 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 216596012824 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596012825 active site 216596012826 phosphorylation site [posttranslational modification] 216596012827 intermolecular recognition site; other site 216596012828 dimerization interface [polypeptide binding]; other site 216596012829 3 probable transmembrane helices predicted at aa 13-35, 50-72 and 93-115 216596012830 Pfam match to entry PF00512.10 HisKA 216596012831 Pfam match to entry PF02518.9 HATPase_c 216596012832 Pfam match to entry PF00072.9 Response_reg 216596012833 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 216596012834 Pfam match to entry PF06823.1 DUF1236 216596012835 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 216596012836 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 216596012837 DXD motif; other site 216596012838 PilZ domain; Region: PilZ; pfam07238 216596012839 8 probable transmembrane helices predicted at aa 17-36, 41-58, 65-82, 97-119,413-435, 439-461, 522-541 and 551-573 216596012840 Pfam match to entry PF00535.10 Glycos_transf_2 216596012841 Bacterial cellulose synthase subunit; Region: BcsB; pfam03170 216596012842 Pfam match to entry PF03170.3 BcsB 216596012843 1 probable transmembrane helix predicted at aa 791-813 216596012844 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 216596012845 Pfam match to entry PF01270.7 Glyco_hydro_8 216596012846 1 probable transmembrane helix predicted at aa 7-29 216596012847 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 216596012848 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 216596012849 motif II; other site 216596012850 Pfam match to entry PF00702.10 Hydrolase 216596012851 Methyltransferase domain; Region: Methyltransf_23; pfam13489 216596012852 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596012853 S-adenosylmethionine binding site [chemical binding]; other site 216596012854 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 216596012855 non-specific DNA binding site [nucleotide binding]; other site 216596012856 salt bridge; other site 216596012857 sequence-specific DNA binding site [nucleotide binding]; other site 216596012858 Transcriptional regulators [Transcription]; Region: MarR; COG1846 216596012859 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 216596012860 non-specific DNA interactions [nucleotide binding]; other site 216596012861 DNA binding site [nucleotide binding] 216596012862 sequence specific DNA binding site [nucleotide binding]; other site 216596012863 putative cAMP binding site [chemical binding]; other site 216596012864 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 216596012865 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 216596012866 nucleotide binding site [chemical binding]; other site 216596012867 Pfam match to entry PF00480.8 ROK 216596012868 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 216596012869 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 216596012870 Pfam match to entry PF00583.9 Acetyltransf_1 216596012871 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 216596012872 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 216596012873 1 probable transmembrane helix predicted at aa 13-35 216596012874 Pfam match to entry PF01547.11 SBP_bac_1 216596012875 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596012876 dimer interface [polypeptide binding]; other site 216596012877 conserved gate region; other site 216596012878 putative PBP binding loops; other site 216596012879 ABC-ATPase subunit interface; other site 216596012880 6 probable transmembrane helices predicted at aa 13-35, 76-98, 110-129, 158-180,205-227 and 264-286 216596012881 Pfam match to entry PF00528.10 BPD_transp_1 216596012882 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216596012883 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596012884 dimer interface [polypeptide binding]; other site 216596012885 conserved gate region; other site 216596012886 putative PBP binding loops; other site 216596012887 ABC-ATPase subunit interface; other site 216596012888 6 probable transmembrane helices predicted at aa 13-35, 79-101, 108-130, 140-162,189-211 and 242-264 216596012889 Pfam match to entry PF00528.10 BPD_transp_1 216596012890 10 probable transmembrane helices predicted at aa 21-38, 66-85, 92-114, 124-146,167-186, 196-230, 242-264, 331-353, 360-379 and 384-402 216596012891 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 216596012892 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 216596012893 Pfam match to entry PF02397.6 Bac_transf 216596012894 5 probable transmembrane helices predicted at aa 66-85, 95-117, 130-148, 158-180 and 329-351 216596012895 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 216596012896 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 216596012897 Pfam match to entry PF00534.8 Glycos_transf_1 216596012898 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 216596012899 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 216596012900 SLBB domain; Region: SLBB; pfam10531 216596012901 Pfam match to entry PF02563.5 Poly_export 216596012902 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 216596012903 Chain length determinant protein; Region: Wzz; pfam02706 216596012904 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 216596012905 Pfam match to entry PF02706.5 Wzz 216596012906 2 probable transmembrane helices predicted at aa 21-43 and 437-459 216596012907 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 216596012908 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 216596012909 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 216596012910 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 216596012911 Pfam match to entry PF02628.4 COX15-CtaA 216596012912 8 probable transmembrane helices predicted at aa 72-94, 158-177, 184-206, 221-243,256-278, 323-345, 352-374 and 379-401 216596012913 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 216596012914 8 probable transmembrane helices predicted at aa 30-52, 65-87, 107-129, 136-153,168-190, 203-225, 230-252 and 259-281 216596012915 Pfam match to entry PF01925.8 DUF81 216596012916 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 216596012917 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 216596012918 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 216596012919 agmatinase; Region: agmatinase; TIGR01230 216596012920 oligomer interface [polypeptide binding]; other site 216596012921 putative active site [active] 216596012922 Mn binding site [ion binding]; other site 216596012923 Pfam match to entry PF00491.9 Arginase 216596012924 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 216596012925 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596012926 putative substrate translocation pore; other site 216596012927 12 probable transmembrane helices predicted at aa 21-43, 58-80, 87-106, 112-134,147-169, 173-195, 216-238, 248-270, 283-305, 315-337,350-372 and 377-396 216596012928 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 216596012929 Pfam match to entry PF00380.7 Ribosomal_S9 216596012930 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 216596012931 23S rRNA interface [nucleotide binding]; other site 216596012932 L3 interface [polypeptide binding]; other site 216596012933 Pfam match to entry PF00572.7 Ribosomal_L13 216596012934 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596012935 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596012936 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 216596012937 dimerization interface [polypeptide binding]; other site 216596012938 Pfam match to entry PF03466.5 LysR_substrate 216596012939 Pfam match to entry PF00126.10 HTH_1 216596012940 enoyl-CoA hydratase; Validated; Region: PRK08139 216596012941 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216596012942 substrate binding site [chemical binding]; other site 216596012943 oxyanion hole (OAH) forming residues; other site 216596012944 trimer interface [polypeptide binding]; other site 216596012945 Pfam match to entry PF00378.8 ECH 216596012946 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 216596012947 10 probable transmembrane helices predicted at aa 5-23, 30-52, 56-78, 85-107,112-134, 141-163, 169-191, 204-226, 231-253 and 258-275 216596012948 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 216596012949 Pfam match to entry PF02629.7 CoA_binding 216596012950 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994 216596012951 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 216596012952 homodimer interface [polypeptide binding]; other site 216596012953 substrate-cofactor binding pocket; other site 216596012954 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596012955 catalytic residue [active] 216596012956 Pfam match to entry PF01053.8 Cys_Met_Meta_PP 216596012957 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 216596012958 Pfam match to entry PF05899.1 DUF861 216596012959 CHASE4 domain; Region: CHASE4; pfam05228 216596012960 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216596012961 metal binding site [ion binding]; metal-binding site 216596012962 active site 216596012963 I-site; other site 216596012964 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216596012965 2 probable transmembrane helices predicted at aa 15-37 and 254-276 216596012966 Pfam match to entry PF00990.8 GGDEF 216596012967 Pfam match to entry PF00563.9 EAL 216596012968 PBP superfamily domain; Region: PBP_like_2; cl17296 216596012969 Pfam match to entry PF01547.11 SBP_bac_1 216596012970 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 216596012971 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596012972 dimer interface [polypeptide binding]; other site 216596012973 conserved gate region; other site 216596012974 putative PBP binding loops; other site 216596012975 ABC-ATPase subunit interface; other site 216596012976 6 probable transmembrane helices predicted at aa 54-76, 114-136, 148-170, 202-224,262-284 and 323-345 216596012977 Pfam match to entry PF00528.10 BPD_transp_1 216596012978 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 216596012979 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596012980 dimer interface [polypeptide binding]; other site 216596012981 conserved gate region; other site 216596012982 putative PBP binding loops; other site 216596012983 ABC-ATPase subunit interface; other site 216596012984 6 probable transmembrane helices predicted at aa 21-43, 78-100, 112-134, 139-158,190-212 and 257-279 216596012985 Pfam match to entry PF00528.10 BPD_transp_1 216596012986 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 216596012987 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 216596012988 Walker A/P-loop; other site 216596012989 ATP binding site [chemical binding]; other site 216596012990 Q-loop/lid; other site 216596012991 ABC transporter signature motif; other site 216596012992 Walker B; other site 216596012993 D-loop; other site 216596012994 H-loop/switch region; other site 216596012995 Pfam match to entry PF00005.11 ABC_tran 216596012996 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 216596012997 Cytochrome P450; Region: p450; cl12078 216596012998 Pfam match to entry PF00067.9 p450 216596012999 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 216596013000 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216596013001 metal binding site [ion binding]; metal-binding site 216596013002 active site 216596013003 I-site; other site 216596013004 Pfam match to entry PF00990.8 GGDEF 216596013005 7 probable transmembrane helices predicted at aa 54-76, 88-110, 120-139, 146-163,173-192, 204-226 and 236-258 216596013006 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 216596013007 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 216596013008 oligomer interface [polypeptide binding]; other site 216596013009 active site residues [active] 216596013010 Pfam match to entry PF00574.9 CLP_protease 216596013011 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 216596013012 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 216596013013 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216596013014 Walker A motif; other site 216596013015 ATP binding site [chemical binding]; other site 216596013016 Walker B motif; other site 216596013017 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 216596013018 Pfam match to entry PF06689.1 zf-C4_ClpX 216596013019 Pfam match to entry PF00004.12 AAA 216596013020 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 216596013021 Found in ATP-dependent protease La (LON); Region: LON; smart00464 216596013022 Found in ATP-dependent protease La (LON); Region: LON; smart00464 216596013023 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216596013024 Walker A motif; other site 216596013025 ATP binding site [chemical binding]; other site 216596013026 Walker B motif; other site 216596013027 arginine finger; other site 216596013028 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 216596013029 Pfam match to entry PF02190.5 LON 216596013030 Pfam match to entry PF00004.12 AAA 216596013031 Pfam match to entry PF05362.2 Lon_C 216596013032 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 216596013033 IHF dimer interface [polypeptide binding]; other site 216596013034 IHF - DNA interface [nucleotide binding]; other site 216596013035 Pfam match to entry PF00216.8 Bac_DNA_binding 216596013036 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 216596013037 8 probable transmembrane helices predicted at aa 62-84, 94-116, 128-150, 154-173,201-220, 235-257, 264-286 and 306-328 216596013038 Pfam match to entry PF00892.8 DUF6 216596013039 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 216596013040 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 216596013041 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 216596013042 active site 216596013043 catalytic tetrad [active] 216596013044 Pfam match to entry PF00248.9 Aldo_ket_red 216596013045 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 216596013046 Methyltransferase domain; Region: Methyltransf_24; pfam13578 216596013047 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 216596013048 catalytic residues [active] 216596013049 dimer interface [polypeptide binding]; other site 216596013050 Pfam match to entry PF00255.8 GSHPx 216596013051 Signal peptide predicted for RL1699 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.966 between residues 22 and 23 216596013052 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 216596013053 3 probable transmembrane helices predicted at aa 20-42, 79-101 and 105-127 216596013054 Pfam match to entry PF00507.7 Oxidored_q4 216596013055 NADH dehydrogenase subunit B; Validated; Region: PRK06411 216596013056 Pfam match to entry PF01058.9 Oxidored_q6 216596013057 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 216596013058 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 216596013059 Pfam match to entry PF00329.7 Complex1_30kDa 216596013060 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 216596013061 NADH dehydrogenase subunit D; Validated; Region: PRK06075 216596013062 Pfam match to entry PF00346.7 Complex1_49kDa 216596013063 NADH dehydrogenase subunit E; Provisional; Region: PRK12373 216596013064 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 216596013065 putative dimer interface [polypeptide binding]; other site 216596013066 [2Fe-2S] cluster binding site [ion binding]; other site 216596013067 Uncharacterized conserved protein [Function unknown]; Region: COG3743 216596013068 Pfam match to entry PF01257.7 Complex1_24kDa 216596013069 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 216596013070 SLBB domain; Region: SLBB; pfam10531 216596013071 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 216596013072 Pfam match to entry PF01512.6 Complex1_51K 216596013073 Uncharacterized conserved protein [Function unknown]; Region: COG3743 216596013074 1 probable transmembrane helix predicted at aa 48-70 216596013075 NADH dehydrogenase subunit G; Validated; Region: PRK09130 216596013076 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 216596013077 catalytic loop [active] 216596013078 iron binding site [ion binding]; other site 216596013079 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 216596013080 MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773 216596013081 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 216596013082 Pfam match to entry PF00111.12 Fer2 216596013083 Pfam match to entry PF00384.9 Molybdopterin 216596013084 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 216596013085 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 216596013086 8 probable transmembrane helices predicted at aa 13-35, 82-101, 116-138, 159-181,201-218, 256-278, 288-310 and 323-345 216596013087 Pfam match to entry PF00146.9 NADHdh 216596013088 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 216596013089 4Fe-4S binding domain; Region: Fer4; pfam00037 216596013090 4Fe-4S binding domain; Region: Fer4; pfam00037 216596013091 Pfam match to entry PF00037.11 Fer4 216596013092 Pfam match to entry PF00037.11 Fer4 216596013093 NADH dehydrogenase subunit 6; Validated; Region: ND6; MTH00021 216596013094 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 216596013095 Pfam match to entry PF00499.7 Oxidored_q3 216596013096 5 probable transmembrane helices predicted at aa 5-24, 31-49, 53-75, 88-110 and 148-170 216596013097 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 216596013098 3 probable transmembrane helices predicted at aa 4-25, 30-52 and 62-84 216596013099 Pfam match to entry PF00420.9 Oxidored_q2 216596013100 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 216596013101 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 216596013102 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 216596013103 NADH dehydrogenase subunit 5 C-terminus; Region: NADH5_C; pfam06455 216596013104 16 probable transmembrane helices predicted at aa 6-25, 32-54, 89-111, 118-135,141-160, 181-203, 235-257, 270-289, 299-321, 328-350,355-377, 397-419, 439-461, 486-505, 539-561 and 641-663 216596013105 Pfam match to entry PF00662.9 Oxidored_q1_N 216596013106 Pfam match to entry PF00361.7 Oxidored_q1 216596013107 Pfam match to entry PF06455.1 NADH5_C 216596013108 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 216596013109 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 216596013110 14 probable transmembrane helices predicted at aa 4-23, 35-57, 86-108, 115-132,136-158, 170-192, 207-229, 242-264, 274-296, 303-325,330-352, 373-395, 410-429 and 454-473 216596013111 Pfam match to entry PF00361.7 Oxidored_q1 216596013112 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 216596013113 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 216596013114 12 probable transmembrane helices predicted at aa 10-32, 39-61, 76-98, 110-132,164-186, 206-228, 243-265, 277-296, 325-347, 372-394,409-431 and 452-474 216596013115 Pfam match to entry PF00361.7 Oxidored_q1 216596013116 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 216596013117 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 216596013118 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 216596013119 Pfam match to entry PF03099.6 BPL_LipA_LipB 216596013120 Pfam match to entry PF02237.6 BPL_C 216596013121 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 216596013122 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 216596013123 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 216596013124 Pfam match to entry PF00753.12 Lactamase_B 216596013125 Pfam match to entry PF07521.1 RMMBL 216596013126 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216596013127 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 216596013128 dimer interface [polypeptide binding]; other site 216596013129 substrate binding site [chemical binding]; other site 216596013130 metal binding site [ion binding]; metal-binding site 216596013131 Pfam match to entry PF00903.11 Glyoxalase 216596013132 Protein of unknown function (DUF1467); Region: DUF1467; cl11569 216596013133 Pfam match to entry PF07330.1 DUF1467 216596013134 2 probable transmembrane helices predicted at aa 28-50 and 71-93 216596013135 prolyl-tRNA synthetase; Provisional; Region: PRK12325 216596013136 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 216596013137 dimer interface [polypeptide binding]; other site 216596013138 motif 1; other site 216596013139 active site 216596013140 motif 2; other site 216596013141 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 216596013142 active site 216596013143 motif 3; other site 216596013144 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 216596013145 anticodon binding site; other site 216596013146 Pfam match to entry PF00587.10 tRNA-synt_2b 216596013147 Pfam match to entry PF03129.7 HGTP_anticodon 216596013148 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 216596013149 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 216596013150 FtsX-like permease family; Region: FtsX; pfam02687 216596013151 6 probable transmembrane helices predicted at aa 41-63, 293-315, 322-341, 345-364,371-388 and 398-420 216596013152 Pfam match to entry PF02687.7 FtsX 216596013153 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 216596013154 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 216596013155 Walker A/P-loop; other site 216596013156 ATP binding site [chemical binding]; other site 216596013157 Q-loop/lid; other site 216596013158 ABC transporter signature motif; other site 216596013159 Walker B; other site 216596013160 D-loop; other site 216596013161 H-loop/switch region; other site 216596013162 Pfam match to entry PF00005.11 ABC_tran 216596013163 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 216596013164 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 216596013165 putative active site [active] 216596013166 putative PHP Thumb interface [polypeptide binding]; other site 216596013167 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 216596013168 generic binding surface II; other site 216596013169 generic binding surface I; other site 216596013170 Pfam match to entry PF02231.5 PHP_N 216596013171 Pfam match to entry PF02811.5 PHP_C 216596013172 Pfam match to entry PF01336.9 tRNA_anti 216596013173 hypothetical protein; Provisional; Region: PRK06132 216596013174 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 216596013175 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 216596013176 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 216596013177 Pfam match to entry PF03734.4 ErfK_YbiS_YhnG 216596013178 1 probable transmembrane helix predicted at aa 7-29 216596013179 DNA polymerase IV; Provisional; Region: PRK02794 216596013180 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 216596013181 active site 216596013182 DNA binding site [nucleotide binding] 216596013183 Pfam match to entry PF00817.8 IMS 216596013184 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216596013185 Coenzyme A binding pocket [chemical binding]; other site 216596013186 Pfam match to entry PF00583.9 Acetyltransf_1 216596013187 hypothetical protein; Provisional; Region: 30.2; PHA02597 216596013188 Protein of unknown function (DUF3572); Region: DUF3572; pfam12096 216596013189 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 216596013190 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596013191 active site 216596013192 phosphorylation site [posttranslational modification] 216596013193 intermolecular recognition site; other site 216596013194 dimerization interface [polypeptide binding]; other site 216596013195 Pfam match to entry PF00072.9 Response_reg 216596013196 response regulator PleD; Reviewed; Region: pleD; PRK09581 216596013197 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596013198 active site 216596013199 phosphorylation site [posttranslational modification] 216596013200 intermolecular recognition site; other site 216596013201 dimerization interface [polypeptide binding]; other site 216596013202 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596013203 active site 216596013204 phosphorylation site [posttranslational modification] 216596013205 intermolecular recognition site; other site 216596013206 dimerization interface [polypeptide binding]; other site 216596013207 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216596013208 metal binding site [ion binding]; metal-binding site 216596013209 active site 216596013210 I-site; other site 216596013211 Pfam match to entry PF00072.9 Response_reg 216596013212 Pfam match to entry PF00072.9 Response_reg 216596013213 Pfam match to entry PF00990.8 GGDEF 216596013214 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 216596013215 Pfam match to entry PF00471.8 Ribosomal_L33 216596013216 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596013217 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216596013218 putative substrate translocation pore; other site 216596013219 11 probable transmembrane helices predicted at aa 20-42, 49-71, 81-103, 110-132,142-164, 169-191, 211-233, 246-268, 300-322, 335-357 and 367-389 216596013220 hypothetical protein; Provisional; Region: PRK05978 216596013221 Pfam match to entry PF06170.1 DUF983 216596013222 2 probable transmembrane helices predicted at aa 104-121 and 126-148 216596013223 ribonuclease R; Region: RNase_R; TIGR02063 216596013224 RNB domain; Region: RNB; pfam00773 216596013225 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 216596013226 RNA binding site [nucleotide binding]; other site 216596013227 Pfam match to entry PF00575.9 S1 216596013228 Pfam match to entry PF00773.7 RNB 216596013229 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 216596013230 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 216596013231 active site 216596013232 interdomain interaction site; other site 216596013233 putative metal-binding site [ion binding]; other site 216596013234 nucleotide binding site [chemical binding]; other site 216596013235 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 216596013236 domain I; other site 216596013237 DNA binding groove [nucleotide binding] 216596013238 phosphate binding site [ion binding]; other site 216596013239 domain II; other site 216596013240 domain III; other site 216596013241 nucleotide binding site [chemical binding]; other site 216596013242 catalytic site [active] 216596013243 domain IV; other site 216596013244 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 216596013245 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 216596013246 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 216596013247 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 216596013248 Pfam match to entry PF01396.7 zf-C4_Topoisom 216596013249 Pfam match to entry PF01131.8 Topoisom_bac 216596013250 Pfam match to entry PF01751.7 Toprim 216596013251 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 216596013252 DNA protecting protein DprA; Region: dprA; TIGR00732 216596013253 Pfam match to entry PF02481.5 SMF 216596013254 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 216596013255 Pfam match to entry PF02660.4 DUF205 216596013256 4 probable transmembrane helices predicted at aa 12-34, 92-111, 118-140 and 150-169 216596013257 dihydroorotase; Validated; Region: PRK09059 216596013258 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 216596013259 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 216596013260 active site 216596013261 Pfam match to entry PF01979.7 Amidohydro_1 216596013262 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 216596013263 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 216596013264 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 216596013265 Pfam match to entry PF00185.8 OTCace 216596013266 Pfam match to entry PF02729.5 OTCace_N 216596013267 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216596013268 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216596013269 active site 216596013270 Pfam match to entry PF02770.6 Acyl-CoA_dh_M 216596013271 Pfam match to entry PF00441.11 Acyl-CoA_dh 216596013272 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 216596013273 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 216596013274 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 216596013275 Pfam match to entry PF00575.9 S1 216596013276 AMIN domain; Region: AMIN; pfam11741 216596013277 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 216596013278 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 216596013279 active site 216596013280 metal binding site [ion binding]; metal-binding site 216596013281 Pfam match to entry PF01520.6 Amidase_3 216596013282 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 216596013283 Transglycosylase; Region: Transgly; pfam00912 216596013284 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 216596013285 1 probable transmembrane helix predicted at aa 5-27 216596013286 Pfam match to entry PF00912.8 Transgly 216596013287 Pfam match to entry PF00905.8 Transpeptidase 216596013288 peptide chain release factor 2; Provisional; Region: PRK07342 216596013289 This domain is found in peptide chain release factors; Region: PCRF; smart00937 216596013290 RF-1 domain; Region: RF-1; pfam00472 216596013291 Pfam match to entry PF03462.5 PCRF 216596013292 Pfam match to entry PF00472.8 RF-1 216596013293 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 216596013294 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 216596013295 Walker A/P-loop; other site 216596013296 ATP binding site [chemical binding]; other site 216596013297 Q-loop/lid; other site 216596013298 ABC transporter signature motif; other site 216596013299 Walker B; other site 216596013300 D-loop; other site 216596013301 H-loop/switch region; other site 216596013302 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 216596013303 Pfam match to entry PF00005.11 ABC_tran 216596013304 Pfam match to entry PF00005.11 ABC_tran 216596013305 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596013306 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216596013307 TM-ABC transporter signature motif; other site 216596013308 9 probable transmembrane helices predicted at aa 46-65, 80-102, 109-131, 136-158,165-184, 204-226, 256-275, 285-307 and 314-336 216596013309 Pfam match to entry PF02653.5 BPD_transp_2 216596013310 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 216596013311 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 216596013312 putative ligand binding site [chemical binding]; other site 216596013313 Pfam match to entry PF00532.8 Peripla_BP_1 216596013314 short chain dehydrogenase; Provisional; Region: PRK06841 216596013315 classical (c) SDRs; Region: SDR_c; cd05233 216596013316 NAD(P) binding site [chemical binding]; other site 216596013317 active site 216596013318 Pfam match to entry PF00106.11 adh_short 216596013319 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 216596013320 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 216596013321 Pfam match to entry PF02733.5 Dak1 216596013322 DAK2 domain; Region: Dak2; pfam02734 216596013323 Pfam match to entry PF02734.5 Dak2 216596013324 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 216596013325 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 216596013326 DNA binding residues [nucleotide binding] 216596013327 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 216596013328 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 216596013329 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 216596013330 Pfam match to entry PF04198.2 Sugar-bind 216596013331 Pfam match to entry PF02733.5 Dak1 216596013332 DAK2 domain; Region: Dak2; cl03685 216596013333 Pfam match to entry PF02734.5 Dak2 216596013334 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 216596013335 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 216596013336 ATP-NAD kinase; Region: NAD_kinase; pfam01513 216596013337 Pfam match to entry PF01513.9 NAD_kinase 216596013338 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 216596013339 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 216596013340 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 216596013341 Pfam match to entry PF00588.7 SpoU_methylase 216596013342 elongation factor Tu; Reviewed; Region: PRK00049 216596013343 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 216596013344 G1 box; other site 216596013345 GEF interaction site [polypeptide binding]; other site 216596013346 GTP/Mg2+ binding site [chemical binding]; other site 216596013347 Switch I region; other site 216596013348 G2 box; other site 216596013349 G3 box; other site 216596013350 Switch II region; other site 216596013351 G4 box; other site 216596013352 G5 box; other site 216596013353 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 216596013354 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 216596013355 Antibiotic Binding Site [chemical binding]; other site 216596013356 Pfam match to entry PF00009.10 GTP_EFTU 216596013357 Pfam match to entry PF03144.8 GTP_EFTU_D2 216596013358 Pfam match to entry PF03143.5 GTP_EFTU_D3 216596013359 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 216596013360 extended (e) SDRs; Region: SDR_e; cd08946 216596013361 NAD(P) binding site [chemical binding]; other site 216596013362 active site 216596013363 substrate binding site [chemical binding]; other site 216596013364 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 216596013365 Pfam match to entry PF00584.8 SecE 216596013366 1 probable transmembrane helix predicted at aa 41-63 216596013367 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 216596013368 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 216596013369 putative homodimer interface [polypeptide binding]; other site 216596013370 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 216596013371 heterodimer interface [polypeptide binding]; other site 216596013372 homodimer interface [polypeptide binding]; other site 216596013373 Pfam match to entry PF02357.6 NusG 216596013374 Pfam match to entry PF00467.13 KOW 216596013375 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 216596013376 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 216596013377 23S rRNA interface [nucleotide binding]; other site 216596013378 L7/L12 interface [polypeptide binding]; other site 216596013379 putative thiostrepton binding site; other site 216596013380 L25 interface [polypeptide binding]; other site 216596013381 Pfam match to entry PF03946.3 Ribosomal_L11_N 216596013382 Pfam match to entry PF00298.8 Ribosomal_L11 216596013383 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 216596013384 mRNA/rRNA interface [nucleotide binding]; other site 216596013385 Pfam match to entry PF00687.8 Ribosomal_L1 216596013386 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 216596013387 23S rRNA interface [nucleotide binding]; other site 216596013388 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 216596013389 Pfam match to entry PF00466.7 Ribosomal_L10 216596013390 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 216596013391 L11 interface [polypeptide binding]; other site 216596013392 putative EF-Tu interaction site [polypeptide binding]; other site 216596013393 putative EF-G interaction site [polypeptide binding]; other site 216596013394 Pfam match to entry PF00542.7 Ribosomal_L12 216596013395 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 216596013396 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 216596013397 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 216596013398 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 216596013399 RPB11 interaction site [polypeptide binding]; other site 216596013400 RPB12 interaction site [polypeptide binding]; other site 216596013401 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 216596013402 RPB1 interaction site [polypeptide binding]; other site 216596013403 RPB11 interaction site [polypeptide binding]; other site 216596013404 RPB10 interaction site [polypeptide binding]; other site 216596013405 RPB3 interaction site [polypeptide binding]; other site 216596013406 Pfam match to entry PF04563.3 RNA_pol_Rpb2_1 216596013407 Pfam match to entry PF04561.3 RNA_pol_Rpb2_2 216596013408 Pfam match to entry PF04565.4 RNA_pol_Rpb2_3 216596013409 Pfam match to entry PF00562.13 RNA_pol_Rpb2_6 216596013410 Pfam match to entry PF04560.6 RNA_pol_Rpb2_7 216596013411 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 216596013412 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 216596013413 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 216596013414 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 216596013415 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 216596013416 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 216596013417 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 216596013418 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 216596013419 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 216596013420 DNA binding site [nucleotide binding] 216596013421 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 216596013422 Pfam match to entry PF04997.2 RNA_pol_Rpb1_1 216596013423 Pfam match to entry PF00623.9 RNA_pol_Rpb1_2 216596013424 Pfam match to entry PF04983.4 RNA_pol_Rpb1_3 216596013425 Pfam match to entry PF05000.4 RNA_pol_Rpb1_4 216596013426 Pfam match to entry PF04998.5 RNA_pol_Rpb1_5 216596013427 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 216596013428 S17 interaction site [polypeptide binding]; other site 216596013429 S8 interaction site; other site 216596013430 16S rRNA interaction site [nucleotide binding]; other site 216596013431 streptomycin interaction site [chemical binding]; other site 216596013432 23S rRNA interaction site [nucleotide binding]; other site 216596013433 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 216596013434 Pfam match to entry PF00164.10 Ribosomal_S12 216596013435 30S ribosomal protein S7; Validated; Region: PRK05302 216596013436 Pfam match to entry PF00177.9 Ribosomal_S7 216596013437 elongation factor G; Reviewed; Region: PRK00007 216596013438 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 216596013439 G1 box; other site 216596013440 putative GEF interaction site [polypeptide binding]; other site 216596013441 GTP/Mg2+ binding site [chemical binding]; other site 216596013442 Switch I region; other site 216596013443 G2 box; other site 216596013444 G3 box; other site 216596013445 Switch II region; other site 216596013446 G4 box; other site 216596013447 G5 box; other site 216596013448 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 216596013449 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 216596013450 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 216596013451 Pfam match to entry PF00009.10 GTP_EFTU 216596013452 Pfam match to entry PF03144.8 GTP_EFTU_D2 216596013453 Pfam match to entry PF03764.4 EFG_IV 216596013454 Pfam match to entry PF00679.10 EFG_C 216596013455 elongation factor Tu; Reviewed; Region: PRK00049 216596013456 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 216596013457 G1 box; other site 216596013458 GEF interaction site [polypeptide binding]; other site 216596013459 GTP/Mg2+ binding site [chemical binding]; other site 216596013460 Switch I region; other site 216596013461 G2 box; other site 216596013462 G3 box; other site 216596013463 Switch II region; other site 216596013464 G4 box; other site 216596013465 G5 box; other site 216596013466 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 216596013467 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 216596013468 Antibiotic Binding Site [chemical binding]; other site 216596013469 Pfam match to entry PF00009.10 GTP_EFTU 216596013470 Pfam match to entry PF03144.8 GTP_EFTU_D2 216596013471 Pfam match to entry PF03143.5 GTP_EFTU_D3 216596013472 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 216596013473 Pfam match to entry PF00338.7 Ribosomal_S10 216596013474 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 216596013475 Pfam match to entry PF00297.9 Ribosomal_L3 216596013476 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 216596013477 Pfam match to entry PF00573.8 Ribosomal_L4 216596013478 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 216596013479 Pfam match to entry PF00276.8 Ribosomal_L23 216596013480 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 216596013481 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 216596013482 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 216596013483 Pfam match to entry PF00181.11 Ribosomal_L2 216596013484 Pfam match to entry PF03947.6 Ribosomal_L2_C 216596013485 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 216596013486 Pfam match to entry PF00203.7 Ribosomal_S19 216596013487 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 216596013488 putative translocon binding site; other site 216596013489 protein-rRNA interface [nucleotide binding]; other site 216596013490 Pfam match to entry PF00237.7 Ribosomal_L22 216596013491 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 216596013492 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 216596013493 G-X-X-G motif; other site 216596013494 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 216596013495 Pfam match to entry PF00417.8 Ribosomal_S3_N 216596013496 Pfam match to entry PF00013.12 KH_1 216596013497 Pfam match to entry PF07650.1 KH_2 216596013498 Pfam match to entry PF00189.8 Ribosomal_S3_C 216596013499 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 216596013500 23S rRNA interface [nucleotide binding]; other site 216596013501 5S rRNA interface [nucleotide binding]; other site 216596013502 putative antibiotic binding site [chemical binding]; other site 216596013503 L25 interface [polypeptide binding]; other site 216596013504 L27 interface [polypeptide binding]; other site 216596013505 Pfam match to entry PF00252.7 Ribosomal_L16 216596013506 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 216596013507 23S rRNA interface [nucleotide binding]; other site 216596013508 putative translocon interaction site; other site 216596013509 signal recognition particle (SRP54) interaction site; other site 216596013510 L23 interface [polypeptide binding]; other site 216596013511 trigger factor interaction site; other site 216596013512 Pfam match to entry PF00831.9 Ribosomal_L29 216596013513 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 216596013514 Pfam match to entry PF00366.7 Ribosomal_S17 216596013515 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 216596013516 Pfam match to entry PF00238.8 Ribosomal_L14 216596013517 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 216596013518 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 216596013519 RNA binding site [nucleotide binding]; other site 216596013520 Pfam match to entry PF00467.13 KOW 216596013521 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 216596013522 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 216596013523 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 216596013524 Pfam match to entry PF00281.8 Ribosomal_L5 216596013525 Pfam match to entry PF00673.8 Ribosomal_L5_C 216596013526 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 216596013527 Pfam match to entry PF00253.9 Ribosomal_S14 216596013528 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 216596013529 Pfam match to entry PF00410.7 Ribosomal_S8 216596013530 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 216596013531 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 216596013532 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 216596013533 Pfam match to entry PF00347.10 Ribosomal_L6 216596013534 Pfam match to entry PF00347.10 Ribosomal_L6 216596013535 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 216596013536 23S rRNA interface [nucleotide binding]; other site 216596013537 L21e interface [polypeptide binding]; other site 216596013538 5S rRNA interface [nucleotide binding]; other site 216596013539 L27 interface [polypeptide binding]; other site 216596013540 L5 interface [polypeptide binding]; other site 216596013541 Pfam match to entry PF00861.9 Ribosomal_L18p 216596013542 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 216596013543 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 216596013544 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 216596013545 Pfam match to entry PF00333.8 Ribosomal_S5 216596013546 Pfam match to entry PF03719.3 Ribosomal_S5_C 216596013547 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 216596013548 23S rRNA binding site [nucleotide binding]; other site 216596013549 Pfam match to entry PF00327.8 Ribosomal_L30 216596013550 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 216596013551 Pfam match to entry PF01305.7 Ribosomal_L15 216596013552 Pfam match to entry PF00256.8 L15 216596013553 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 216596013554 SecY translocase; Region: SecY; pfam00344 216596013555 8 probable transmembrane helices predicted at aa 79-101, 154-176, 183-205,215-237, 275-297, 317-339, 370-392 and 397-419 216596013556 Pfam match to entry PF00344.7 SecY 216596013557 adenylate kinase; Reviewed; Region: adk; PRK00279 216596013558 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 216596013559 AMP-binding site [chemical binding]; other site 216596013560 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 216596013561 Pfam match to entry PF00406.10 ADK 216596013562 Pfam match to entry PF05191.2 ADK_lid 216596013563 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 216596013564 30S ribosomal protein S13; Region: bact_S13; TIGR03631 216596013565 Pfam match to entry PF00416.9 Ribosomal_S13 216596013566 30S ribosomal protein S11; Validated; Region: PRK05309 216596013567 Pfam match to entry PF00411.7 Ribosomal_S11 216596013568 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 216596013569 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 216596013570 alphaNTD homodimer interface [polypeptide binding]; other site 216596013571 alphaNTD - beta interaction site [polypeptide binding]; other site 216596013572 alphaNTD - beta' interaction site [polypeptide binding]; other site 216596013573 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 216596013574 Pfam match to entry PF01193.9 RNA_pol_L 216596013575 Pfam match to entry PF01000.12 RNA_pol_A_bac 216596013576 Pfam match to entry PF03118.4 RNA_pol_A_CTD 216596013577 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 216596013578 Pfam match to entry PF01196.7 Ribosomal_L17 216596013579 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 216596013580 4 probable transmembrane helices predicted at aa 12-31, 46-63, 68-90 and 105-127 216596013581 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 216596013582 Pfam match to entry PF05252.1 UPF0191 216596013583 6 probable transmembrane helices predicted at aa 12-34, 54-76, 83-105, 120-142,151-170 and 180-199 216596013584 TMAO/DMSO reductase; Reviewed; Region: PRK05363 216596013585 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 216596013586 Moco binding site; other site 216596013587 metal coordination site [ion binding]; other site 216596013588 Pfam match to entry PF00174.8 Oxidored_molyb 216596013589 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 216596013590 Pfam match to entry PF00920.9 ILVD_EDD 216596013591 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 216596013592 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 216596013593 1 probable transmembrane helix predicted at aa 104-123 216596013594 Pfam match to entry PF06803.1 DUF1232 216596013595 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 216596013596 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 216596013597 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 216596013598 protein binding site [polypeptide binding]; other site 216596013599 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 216596013600 protein binding site [polypeptide binding]; other site 216596013601 Pfam match to entry PF00089.9 Trypsin 216596013602 Pfam match to entry PF00595.8 PDZ 216596013603 Pfam match to entry PF00595.8 PDZ 216596013604 recombination factor protein RarA; Reviewed; Region: PRK13342 216596013605 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216596013606 Walker A motif; other site 216596013607 ATP binding site [chemical binding]; other site 216596013608 Walker B motif; other site 216596013609 arginine finger; other site 216596013610 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 216596013611 Pfam match to entry PF00004.12 AAA 216596013612 Domain of unknown function (DUF1883); Region: DUF1883; pfam08980 216596013613 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 216596013614 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 216596013615 dimer interface [polypeptide binding]; other site 216596013616 active site 216596013617 catalytic residue [active] 216596013618 Pfam match to entry PF00701.10 DHDPS 216596013619 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 216596013620 Pfam match to entry PF00561.8 Abhydrolase_1 216596013621 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 216596013622 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 216596013623 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 216596013624 Pfam match to entry PF02558.4 ApbA 216596013625 short chain dehydrogenase; Provisional; Region: PRK06180 216596013626 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 216596013627 NADP binding site [chemical binding]; other site 216596013628 active site 216596013629 steroid binding site; other site 216596013630 Pfam match to entry PF00106.11 adh_short 216596013631 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596013632 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596013633 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 216596013634 putative effector binding pocket; other site 216596013635 putative dimerization interface [polypeptide binding]; other site 216596013636 Pfam match to entry PF00126.10 HTH_1 216596013637 Pfam match to entry PF03466.5 LysR_substrate 216596013638 Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism]; Region: COG3613 216596013639 Pfam match to entry PF05014.4 Nuc_deoxyrib_tr 216596013640 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 216596013641 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 216596013642 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 216596013643 PAS domain; Region: PAS; smart00091 216596013644 PAS fold; Region: PAS_7; pfam12860 216596013645 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 216596013646 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216596013647 dimer interface [polypeptide binding]; other site 216596013648 phosphorylation site [posttranslational modification] 216596013649 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596013650 ATP binding site [chemical binding]; other site 216596013651 Mg2+ binding site [ion binding]; other site 216596013652 G-X-G motif; other site 216596013653 Pfam match to entry PF02518.9 HATPase_c 216596013654 Pfam match to entry PF00512.10 HisKA 216596013655 Pfam match to entry PF00989.11 PAS 216596013656 Pfam match to entry PF00989.11 PAS 216596013657 Transcriptional regulators [Transcription]; Region: PurR; COG1609 216596013658 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216596013659 DNA binding site [nucleotide binding] 216596013660 domain linker motif; other site 216596013661 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 216596013662 putative dimerization interface [polypeptide binding]; other site 216596013663 putative ligand binding site [chemical binding]; other site 216596013664 Pfam match to entry PF00356.8 LacI 216596013665 Pfam match to entry PF00532.8 Peripla_BP_1 216596013666 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 216596013667 Coenzyme A transferase; Region: CoA_trans; smart00882 216596013668 Coenzyme A transferase; Region: CoA_trans; cl17247 216596013669 Pfam match to entry PF01144.9 CoA_trans 216596013670 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 216596013671 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216596013672 substrate binding site [chemical binding]; other site 216596013673 oxyanion hole (OAH) forming residues; other site 216596013674 trimer interface [polypeptide binding]; other site 216596013675 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 216596013676 Pfam match to entry PF00378.8 ECH 216596013677 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 216596013678 Gluconobacter oxydans L-sorbosone dehydrogenase-like; Region: ALDH_SNDH; cd07118 216596013679 NAD(P) binding site [chemical binding]; other site 216596013680 catalytic residues [active] 216596013681 Pfam match to entry PF00171.9 Aldedh 216596013682 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 216596013683 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 216596013684 Pfam match to entry PF01547.11 SBP_bac_1 216596013685 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 216596013686 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596013687 dimer interface [polypeptide binding]; other site 216596013688 putative PBP binding loops; other site 216596013689 ABC-ATPase subunit interface; other site 216596013690 6 probable transmembrane helices predicted at aa 32-54, 97-119, 132-151, 181-203,232-251 and 287-309 216596013691 Pfam match to entry PF00528.10 BPD_transp_1 216596013692 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216596013693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596013694 dimer interface [polypeptide binding]; other site 216596013695 conserved gate region; other site 216596013696 putative PBP binding loops; other site 216596013697 ABC-ATPase subunit interface; other site 216596013698 6 probable transmembrane helices predicted at aa 21-43, 98-117, 129-151, 176-198,219-241 and 283-305 216596013699 Pfam match to entry PF00528.10 BPD_transp_1 216596013700 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 216596013701 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 216596013702 Walker A/P-loop; other site 216596013703 ATP binding site [chemical binding]; other site 216596013704 Q-loop/lid; other site 216596013705 ABC transporter signature motif; other site 216596013706 Walker B; other site 216596013707 D-loop; other site 216596013708 H-loop/switch region; other site 216596013709 Pfam match to entry PF00005.11 ABC_tran 216596013710 Pfam match to entry PF03459.4 TOBE 216596013711 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 216596013712 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 216596013713 1 probable transmembrane helix predicted at aa 7-26 216596013714 choline dehydrogenase; Validated; Region: PRK02106 216596013715 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 216596013716 Pfam match to entry PF00732.8 GMC_oxred_N 216596013717 Pfam match to entry PF05199.2 GMC_oxred_C 216596013718 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 216596013719 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 216596013720 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 216596013721 Pfam match to entry PF01408.8 GFO_IDH_MocA 216596013722 Pfam match to entry PF02894.4 GFO_IDH_MocA_C 216596013723 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 216596013724 L-aspartate oxidase; Provisional; Region: PRK06175 216596013725 Pfam match to entry PF00890.10 FAD_binding_2 216596013726 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 216596013727 putative catalytic site [active] 216596013728 putative phosphate binding site [ion binding]; other site 216596013729 active site 216596013730 metal binding site A [ion binding]; metal-binding site 216596013731 DNA binding site [nucleotide binding] 216596013732 putative AP binding site [nucleotide binding]; other site 216596013733 putative metal binding site B [ion binding]; other site 216596013734 Pfam match to entry PF03372.6 Exo_endo_phos 216596013735 1 probable transmembrane helix predicted at aa 12-34 216596013736 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 216596013737 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596013738 active site 216596013739 phosphorylation site [posttranslational modification] 216596013740 intermolecular recognition site; other site 216596013741 dimerization interface [polypeptide binding]; other site 216596013742 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216596013743 DNA binding residues [nucleotide binding] 216596013744 dimerization interface [polypeptide binding]; other site 216596013745 Pfam match to entry PF00196.8 GerE 216596013746 Pfam match to entry PF00072.9 Response_reg 216596013747 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 216596013748 Histidine kinase; Region: HisKA_3; pfam07730 216596013749 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596013750 ATP binding site [chemical binding]; other site 216596013751 Mg2+ binding site [ion binding]; other site 216596013752 G-X-G motif; other site 216596013753 Pfam match to entry PF02518.9 HATPase_c 216596013754 2 probable transmembrane helices predicted at aa 13-35 and 191-213 216596013755 1 probable transmembrane helix predicted at aa 29-51 216596013756 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596013757 S-adenosylmethionine binding site [chemical binding]; other site 216596013758 Pfam match to entry PF01209.8 Ubie_methyltran 216596013759 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 216596013760 2 probable transmembrane helices predicted at aa 5-27 and 37-59 216596013761 Pfam match to entry PF06823.1 DUF1236 216596013762 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 216596013763 Pfam match to entry PF06823.1 DUF1236 216596013764 BA14K-like protein; Region: BA14K; pfam07886 216596013765 BA14K-like protein; Region: BA14K; pfam07886 216596013766 1 probable transmembrane helix predicted at aa 7-29 216596013767 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596013768 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596013769 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 216596013770 putative effector binding pocket; other site 216596013771 putative dimerization interface [polypeptide binding]; other site 216596013772 Pfam match to entry PF03466.5 LysR_substrate 216596013773 Pfam match to entry PF00126.10 HTH_1 216596013774 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 216596013775 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 216596013776 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 216596013777 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 216596013778 Pfam match to entry PF03734.4 ErfK_YbiS_YhnG 216596013779 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 216596013780 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596013781 active site 216596013782 phosphorylation site [posttranslational modification] 216596013783 intermolecular recognition site; other site 216596013784 dimerization interface [polypeptide binding]; other site 216596013785 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216596013786 DNA binding residues [nucleotide binding] 216596013787 dimerization interface [polypeptide binding]; other site 216596013788 Pfam match to entry PF00196.8 GerE 216596013789 Pfam match to entry PF00072.9 Response_reg 216596013790 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 216596013791 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216596013792 DNA binding site [nucleotide binding] 216596013793 AAA ATPase domain; Region: AAA_16; pfam13191 216596013794 Predicted ATPase [General function prediction only]; Region: COG3903 216596013795 Pfam match to entry PF00486.11 Trans_reg_C 216596013796 Pfam match to entry PF06498.1 Ad_Cycl_assoc 216596013797 Pfam match to entry PF06492.1 DUF1095 216596013798 Epoxide hydrolase N terminus; Region: EHN; pfam06441 216596013799 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 216596013800 Pfam match to entry PF06441.1 EHN 216596013801 1 probable transmembrane helix predicted at aa 13-35 216596013802 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 216596013803 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216596013804 Pfam match to entry PF00903.11 Glyoxalase 216596013805 Isochorismatase family; Region: Isochorismatase; pfam00857 216596013806 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 216596013807 catalytic triad [active] 216596013808 conserved cis-peptide bond; other site 216596013809 Pfam match to entry PF00857.9 Isochorismatase 216596013810 enoyl-CoA hydratase; Provisional; Region: PRK07511 216596013811 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216596013812 substrate binding site [chemical binding]; other site 216596013813 oxyanion hole (OAH) forming residues; other site 216596013814 trimer interface [polypeptide binding]; other site 216596013815 Pfam match to entry PF00378.8 ECH 216596013816 1 probable transmembrane helix predicted at aa 13-35 216596013817 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 216596013818 homotrimer interaction site [polypeptide binding]; other site 216596013819 putative active site [active] 216596013820 Pfam match to entry PF01042.8 Ribonuc_L-PSP 216596013821 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 216596013822 classical (c) SDRs; Region: SDR_c; cd05233 216596013823 NAD(P) binding site [chemical binding]; other site 216596013824 active site 216596013825 Pfam match to entry PF00106.11 adh_short 216596013826 SnoaL-like domain; Region: SnoaL_3; pfam13474 216596013827 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 216596013828 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 216596013829 potential catalytic triad [active] 216596013830 conserved cys residue [active] 216596013831 Pfam match to entry PF01965.9 DJ-1_PfpI 216596013832 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 216596013833 Peptidase S8 family domain, uncharacterized subfamily 12; Region: Peptidases_S8_12; cd07480 216596013834 active site 216596013835 catalytic triad [active] 216596013836 Pfam match to entry PF00082.10 Peptidase_S8 216596013837 Uncharacterized bacterial family of heme peroxidases; Region: An_peroxidase_bacterial_1; cd09819 216596013838 putative heme binding site [chemical binding]; other site 216596013839 putative substrate binding site [chemical binding]; other site 216596013840 Pfam match to entry PF03098.5 An_peroxidase 216596013841 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 216596013842 cofactor binding site; other site 216596013843 metal binding site [ion binding]; metal-binding site 216596013844 Pfam match to entry PF00351.10 Biopterin_H 216596013845 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216596013846 putative DNA binding site [nucleotide binding]; other site 216596013847 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 216596013848 putative Zn2+ binding site [ion binding]; other site 216596013849 AsnC family; Region: AsnC_trans_reg; pfam01037 216596013850 Pfam match to entry PF01037.8 AsnC_trans_reg 216596013851 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 216596013852 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 216596013853 putative DNA binding site [nucleotide binding]; other site 216596013854 putative Zn2+ binding site [ion binding]; other site 216596013855 AsnC family; Region: AsnC_trans_reg; pfam01037 216596013856 Pfam match to entry PF01037.8 AsnC_trans_reg 216596013857 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 216596013858 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 216596013859 dimer interface [polypeptide binding]; other site 216596013860 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 216596013861 active site 216596013862 Fe binding site [ion binding]; other site 216596013863 Pfam match to entry PF00903.11 Glyoxalase 216596013864 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 216596013865 Pfam match to entry PF04209.3 HgmA 216596013866 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 216596013867 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 216596013868 Pfam match to entry PF01557.8 FAA_hydrolase 216596013869 maleylacetoacetate isomerase; Region: maiA; TIGR01262 216596013870 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 216596013871 C-terminal domain interface [polypeptide binding]; other site 216596013872 GSH binding site (G-site) [chemical binding]; other site 216596013873 putative dimer interface [polypeptide binding]; other site 216596013874 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 216596013875 dimer interface [polypeptide binding]; other site 216596013876 N-terminal domain interface [polypeptide binding]; other site 216596013877 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 216596013878 Pfam match to entry PF02798.6 GST_N 216596013879 Pfam match to entry PF00043.11 GST_C 216596013880 Predicted periplasmic protein [Function unknown]; Region: COG3904 216596013881 1 probable transmembrane helix predicted at aa 12-34 216596013882 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 216596013883 Ligand Binding Site [chemical binding]; other site 216596013884 Pfam match to entry PF00582.12 Usp 216596013885 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 216596013886 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 216596013887 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 216596013888 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 216596013889 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216596013890 motif II; other site 216596013891 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 216596013892 Pfam match to entry PF00689.9 Cation_ATPase_C 216596013893 8 probable transmembrane helices predicted at aa 56-73, 77-96, 238-260, 270-292,686-708, 765-787, 826-848 and 852-874 216596013894 Pfam match to entry PF00702.10 Hydrolase 216596013895 Pfam match to entry PF00122.7 E1-E2_ATPase 216596013896 Pfam match to entry PF00690.11 Cation_ATPase_N 216596013897 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 216596013898 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 216596013899 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 216596013900 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216596013901 active site 216596013902 motif I; other site 216596013903 motif II; other site 216596013904 5 probable transmembrane helices predicted at aa 29-48, 53-75, 252-272, 277-299 and 577-599 216596013905 Pfam match to entry PF00122.7 E1-E2_ATPase 216596013906 Pfam match to entry PF00702.10 Hydrolase 216596013907 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 216596013908 Ligand Binding Site [chemical binding]; other site 216596013909 Pfam match to entry PF00582.12 Usp 216596013910 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 216596013911 Pfam match to entry PF01243.8 Pyridox_oxidase 216596013912 1 probable transmembrane helix predicted at aa 107-129 216596013913 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 216596013914 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 216596013915 putative NAD(P) binding site [chemical binding]; other site 216596013916 putative substrate binding site [chemical binding]; other site 216596013917 catalytic Zn binding site [ion binding]; other site 216596013918 structural Zn binding site [ion binding]; other site 216596013919 Pfam match to entry PF00107.10 ADH_zinc_N 216596013920 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 216596013921 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 216596013922 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 216596013923 protein binding site [polypeptide binding]; other site 216596013924 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 216596013925 Pfam match to entry PF00089.9 Trypsin 216596013926 Pfam match to entry PF00595.8 PDZ 216596013927 Pfam match to entry PF00595.8 PDZ 216596013928 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 216596013929 BON domain; Region: BON; pfam04972 216596013930 BON domain; Region: BON; pfam04972 216596013931 Pfam match to entry PF04972.3 BON 216596013932 Pfam match to entry PF04972.3 BON 216596013933 Pfam match to entry PF04972.3 BON 216596013934 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216596013935 putative active site [active] 216596013936 heme pocket [chemical binding]; other site 216596013937 PAS domain S-box; Region: sensory_box; TIGR00229 216596013938 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216596013939 putative active site [active] 216596013940 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 216596013941 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216596013942 dimer interface [polypeptide binding]; other site 216596013943 phosphorylation site [posttranslational modification] 216596013944 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596013945 ATP binding site [chemical binding]; other site 216596013946 Mg2+ binding site [ion binding]; other site 216596013947 G-X-G motif; other site 216596013948 Response regulator receiver domain; Region: Response_reg; pfam00072 216596013949 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596013950 active site 216596013951 phosphorylation site [posttranslational modification] 216596013952 intermolecular recognition site; other site 216596013953 dimerization interface [polypeptide binding]; other site 216596013954 Pfam match to entry PF00072.9 Response_reg 216596013955 Pfam match to entry PF02518.9 HATPase_c 216596013956 Pfam match to entry PF00512.10 HisKA 216596013957 Pfam match to entry PF00989.11 PAS 216596013958 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 216596013959 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 216596013960 ligand binding site [chemical binding]; other site 216596013961 flexible hinge region; other site 216596013962 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 216596013963 putative switch regulator; other site 216596013964 non-specific DNA interactions [nucleotide binding]; other site 216596013965 DNA binding site [nucleotide binding] 216596013966 sequence specific DNA binding site [nucleotide binding]; other site 216596013967 putative cAMP binding site [chemical binding]; other site 216596013968 Pfam match to entry PF00325.9 Crp 216596013969 Pfam match to entry PF00027.13 cNMP_binding 216596013970 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 216596013971 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596013972 active site 216596013973 phosphorylation site [posttranslational modification] 216596013974 intermolecular recognition site; other site 216596013975 dimerization interface [polypeptide binding]; other site 216596013976 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216596013977 DNA binding site [nucleotide binding] 216596013978 Pfam match to entry PF00072.9 Response_reg 216596013979 Pfam match to entry PF00486.11 Trans_reg_C 216596013980 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 216596013981 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 216596013982 putative dimer interface [polypeptide binding]; other site 216596013983 Pfam match to entry PF00011.8 HSP20 216596013984 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 216596013985 BON domain; Region: BON; pfam04972 216596013986 BON domain; Region: BON; pfam04972 216596013987 BON domain; Region: BON; pfam04972 216596013988 Pfam match to entry PF04972.3 BON 216596013989 Pfam match to entry PF04972.3 BON 216596013990 Pfam match to entry PF04972.3 BON 216596013991 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 216596013992 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 216596013993 Beta-Casp domain; Region: Beta-Casp; smart01027 216596013994 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 216596013995 Pfam match to entry PF00753.12 Lactamase_B 216596013996 Pfam match to entry PF07521.1 RMMBL 216596013997 Acetokinase family; Region: Acetate_kinase; cl17229 216596013998 propionate/acetate kinase; Provisional; Region: PRK12379 216596013999 Pfam match to entry PF00871.7 Acetate_kinase 216596014000 2 probable transmembrane helices predicted at aa 25-47 and 74-96 216596014001 1 probable transmembrane helix predicted at aa 9-31 216596014002 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 216596014003 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 216596014004 Multicopper oxidase; Region: Cu-oxidase; pfam00394 216596014005 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 216596014006 Pfam match to entry PF00394.10 Cu-oxidase 216596014007 Protein of unknown function (DUF2933); Region: DUF2933; pfam11666 216596014008 2 probable transmembrane helices predicted at aa 13-30 and 37-56 216596014009 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 216596014010 4 probable transmembrane helices predicted at aa 5-27, 39-61, 97-119 and 148-170 216596014011 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 216596014012 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 216596014013 Soluble P-type ATPase [General function prediction only]; Region: COG4087 216596014014 8 probable transmembrane helices predicted at aa 87-104, 114-136, 149-171,186-208, 341-363, 378-400, 685-707 and 712-734 216596014015 Pfam match to entry PF00122.7 E1-E2_ATPase 216596014016 Pfam match to entry PF00702.10 Hydrolase 216596014017 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 216596014018 EF-hand domain pair; Region: EF_hand_5; pfam13499 216596014019 Ca2+ binding site [ion binding]; other site 216596014020 2 probable transmembrane helices predicted at aa 33-55 and 103-120 216596014021 Pfam match to entry PF00036.14 efhand 216596014022 Pfam match to entry PF00036.14 efhand 216596014023 TniQ; Region: TniQ; pfam06527 216596014024 AAA domain; Region: AAA_22; pfam13401 216596014025 Integrase core domain; Region: rve; pfam00665 216596014026 Pfam match to entry PF00665.10 rve 216596014027 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 216596014028 oligomeric interface; other site 216596014029 putative active site [active] 216596014030 homodimer interface [polypeptide binding]; other site 216596014031 Pfam match to entry PF01850.8 PIN 216596014032 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 216596014033 7 probable transmembrane helices predicted at aa 30-52, 65-87, 126-148, 158-177,220-242, 252-274 and 341-363 216596014034 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 216596014035 Mechanosensitive ion channel; Region: MS_channel; pfam00924 216596014036 Pfam match to entry PF00924.8 MS_channel 216596014037 11 probable transmembrane helices predicted at aa 5-22, 108-127, 140-157, 162-184,197-219, 223-245, 258-280, 310-332, 345-367, 399-421 and 428-450 216596014038 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 216596014039 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 216596014040 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216596014041 motif II; other site 216596014042 1 probable transmembrane helix predicted at aa 12-31 216596014043 Uncharacterized conserved protein [Function unknown]; Region: COG1262 216596014044 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 216596014045 Pfam match to entry PF03781.4 DUF323 216596014046 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 216596014047 Sulfatase; Region: Sulfatase; pfam00884 216596014048 Pfam match to entry PF00884.10 Sulfatase 216596014049 1 probable transmembrane helix predicted at aa 22-44 216596014050 Oxygen tolerance; Region: BatD; pfam13584 216596014051 von Willebrand factor type A domain; Region: VWA_2; pfam13519 216596014052 metal ion-dependent adhesion site (MIDAS); other site 216596014053 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216596014054 TPR motif; other site 216596014055 binding surface 216596014056 TPR repeat; Region: TPR_11; pfam13414 216596014057 Pfam match to entry PF00515.11 TPR 216596014058 Pfam match to entry PF00515.11 TPR 216596014059 Pfam match to entry PF00092.11 VWA 216596014060 2 probable transmembrane helices predicted at aa 5-27 and 58-80 216596014061 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 216596014062 metal ion-dependent adhesion site (MIDAS); other site 216596014063 1 probable transmembrane helix predicted at aa 301-323 216596014064 Pfam match to entry PF00092.11 VWA 216596014065 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 216596014066 1 probable transmembrane helix predicted at aa 10-29 216596014067 Protein of unknown function DUF58; Region: DUF58; pfam01882 216596014068 Pfam match to entry PF01882.7 DUF58 216596014069 MoxR-like ATPases [General function prediction only]; Region: COG0714 216596014070 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216596014071 Walker A motif; other site 216596014072 ATP binding site [chemical binding]; other site 216596014073 Walker B motif; other site 216596014074 arginine finger; other site 216596014075 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 216596014076 Sulfatase; Region: Sulfatase; pfam00884 216596014077 Pfam match to entry PF00884.10 Sulfatase 216596014078 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 216596014079 Pfam match to entry PF05990.1 DUF900 216596014080 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 216596014081 1 probable transmembrane helix predicted at aa 13-35 216596014082 Bacterial SH3 domain; Region: SH3_3; pfam08239 216596014083 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 216596014084 TPR motif; other site 216596014085 binding surface 216596014086 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216596014087 binding surface 216596014088 TPR motif; other site 216596014089 Uncharacterized conserved protein [Function unknown]; Region: COG5361 216596014090 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 216596014091 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 216596014092 Pfam match to entry PF06863.1 DUF1254 216596014093 Pfam match to entry PF06742.1 DUF1214 216596014094 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 216596014095 Uncharacterized conserved protein [Function unknown]; Region: COG5361 216596014096 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 216596014097 Pfam match to entry PF06742.1 DUF1214 216596014098 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 216596014099 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 216596014100 Autotransporter beta-domain; Region: Autotransporter; smart00869 216596014101 1 probable transmembrane helix predicted at aa 13-35 216596014102 Pfam match to entry PF05594.2 Fil_haemagg 216596014103 Pfam match to entry PF03212.4 Pertactin 216596014104 Pfam match to entry PF03797.5 Autotransporter 216596014105 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 216596014106 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216596014107 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 216596014108 Walker A motif; other site 216596014109 ATP binding site [chemical binding]; other site 216596014110 Walker B motif; other site 216596014111 arginine finger; other site 216596014112 Peptidase family M41; Region: Peptidase_M41; pfam01434 216596014113 Pfam match to entry PF00004.12 AAA 216596014114 Pfam match to entry PF01434.6 Peptidase_M41 216596014115 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 216596014116 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 216596014117 cofactor binding site; other site 216596014118 DNA binding site [nucleotide binding] 216596014119 substrate interaction site [chemical binding]; other site 216596014120 Pfam match to entry PF00145.7 DNA_methylase 216596014121 FRG domain; Region: FRG; pfam08867 216596014122 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 216596014123 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 216596014124 Pfam match to entry PF00805.11 Pentapeptide 216596014125 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 216596014126 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 216596014127 active site 216596014128 metal binding site [ion binding]; metal-binding site 216596014129 Pfam match to entry PF00149.12 Metallophos 216596014130 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 216596014131 active site 216596014132 NTP binding site [chemical binding]; other site 216596014133 metal binding triad [ion binding]; metal-binding site 216596014134 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 216596014135 active site 216596014136 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 216596014137 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 216596014138 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 216596014139 Transcriptional regulator; Region: Transcrip_reg; cl00361 216596014140 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 216596014141 active site 216596014142 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 216596014143 TSCPD domain; Region: TSCPD; pfam12637 216596014144 Pfam match to entry PF02867.4 Ribonuc_red_lgC 216596014145 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 216596014146 active site 216596014147 Pfam match to entry PF00156.11 Pribosyltran 216596014148 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 216596014149 Ligand Binding Site [chemical binding]; other site 216596014150 Pfam match to entry PF00582.12 Usp 216596014151 Pfam match to entry PF00582.12 Usp 216596014152 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 216596014153 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 216596014154 putative MPT binding site; other site 216596014155 Pfam match to entry PF00994.10 MoCF_biosynth 216596014156 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 216596014157 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 216596014158 Pfam match to entry PF00258.10 Flavodoxin_1 216596014159 VanZ like family; Region: VanZ; cl01971 216596014160 4 probable transmembrane helices predicted at aa 63-80, 95-109, 116-134 and 144-161 216596014161 threonine dehydratase; Validated; Region: PRK08639 216596014162 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 216596014163 tetramer interface [polypeptide binding]; other site 216596014164 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596014165 catalytic residue [active] 216596014166 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 216596014167 Pfam match to entry PF00291.10 PALP 216596014168 Pfam match to entry PF00585.7 Thr_dehydrat_C 216596014169 Transcriptional activator HlyU; Region: HlyU; pfam10115 216596014170 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 216596014171 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216596014172 metal binding site [ion binding]; metal-binding site 216596014173 active site 216596014174 I-site; other site 216596014175 7 probable transmembrane helices predicted at aa 5-27, 34-56, 66-83, 95-113,133-155, 167-189 and 199-221 216596014176 Pfam match to entry PF00990.8 GGDEF 216596014177 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596014178 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216596014179 12 probable transmembrane helices predicted at aa 25-47, 57-79, 84-106, 116-138,147-169, 179-201, 222-244, 259-281, 288-310, 314-336,349-371 and 376-398 216596014180 short chain dehydrogenase; Provisional; Region: PRK06500 216596014181 classical (c) SDRs; Region: SDR_c; cd05233 216596014182 NAD(P) binding site [chemical binding]; other site 216596014183 active site 216596014184 Pfam match to entry PF00106.11 adh_short 216596014185 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216596014186 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216596014187 Pfam match to entry PF00440.8 TetR_N 216596014188 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 216596014189 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 216596014190 Pfam match to entry PF02525.5 Flavodoxin_2 216596014191 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596014192 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596014193 LysR substrate binding domain; Region: LysR_substrate; pfam03466 216596014194 dimerization interface [polypeptide binding]; other site 216596014195 Pfam match to entry PF00126.10 HTH_1 216596014196 Pfam match to entry PF03466.5 LysR_substrate 216596014197 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 216596014198 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 216596014199 active site 216596014200 metal binding site [ion binding]; metal-binding site 216596014201 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 216596014202 Pfam match to entry PF02872.7 5_nucleotid_C 216596014203 Pfam match to entry PF00149.12 Metallophos 216596014204 2 probable transmembrane helices predicted at aa 5-27 and 42-64 216596014205 PilZ domain; Region: PilZ; pfam07238 216596014206 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 216596014207 10 probable transmembrane helices predicted at aa 7-25, 30-52, 73-95, 100-117,122-139, 149-168, 181-203, 208-227, 234-256 and 261-280 216596014208 Pfam match to entry PF00892.8 DUF6 216596014209 Pfam match to entry PF00892.8 DUF6 216596014210 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 216596014211 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216596014212 putative DNA binding site [nucleotide binding]; other site 216596014213 putative Zn2+ binding site [ion binding]; other site 216596014214 AsnC family; Region: AsnC_trans_reg; pfam01037 216596014215 Pfam match to entry PF01037.8 AsnC_trans_reg 216596014216 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 216596014217 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 216596014218 hexamer interface [polypeptide binding]; other site 216596014219 ligand binding site [chemical binding]; other site 216596014220 putative active site [active] 216596014221 NAD(P) binding site [chemical binding]; other site 216596014222 Pfam match to entry PF05222.2 AlaDh_PNT_N 216596014223 Pfam match to entry PF01262.8 AlaDh_PNT_C 216596014224 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 216596014225 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 216596014226 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216596014227 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216596014228 Pfam match to entry PF00165.8 HTH_AraC 216596014229 Pfam match to entry PF00165.8 HTH_AraC 216596014230 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 216596014231 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216596014232 NAD(P) binding site [chemical binding]; other site 216596014233 active site 216596014234 Pfam match to entry PF00106.11 adh_short 216596014235 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 216596014236 Pfam match to entry PF01613.6 Flavin_Reduct 216596014237 Uncharacterized conserved protein [Function unknown]; Region: COG5470 216596014238 Pfam match to entry PF07045.1 DUF1330 216596014239 Protein of unknown function (DUF1203); Region: DUF1203; pfam06718 216596014240 Pfam match to entry PF06718.1 DUF1203 216596014241 Transposase; Region: DEDD_Tnp_IS110; pfam01548 216596014242 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 216596014243 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 216596014244 Pfam match to entry PF02371.5 Transposase_20 216596014245 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596014246 S-adenosylmethionine binding site [chemical binding]; other site 216596014247 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 216596014248 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 216596014249 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 216596014250 active site residue [active] 216596014251 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 216596014252 active site residue [active] 216596014253 Pfam match to entry PF00581.7 Rhodanese 216596014254 Pfam match to entry PF00581.7 Rhodanese 216596014255 Similar to C-terminus from codon 470 of Escherichia coli AlaS alanyl-tRNA synthetase (ec 6.1.1.7) (alanine--tRNA ligase) (AlaRS). UniProt:SYA_ECOLI (EMBL:ECDALAS3) (876 aa), and to entire protein of Agrobacterium tumefaciens (strain C58/ATCC 33970) AlaS alanyl-tRNA synthetase (agr_c_2246p). UniProt:Q8UG26_AGRT5 (EMBL:AE008050) (245 aa); similarity:fasta; with=UniProt:SYA_ECOLI (EMBL:ECDALAS3); Escherichia coli.; alaS; Alanyl-tRNA synthetase (EC 6.1.1.7) (Alanine--tRNA ligase) (AlaRS).; length=876; id 29.956; 227 aa overlap; query 3-217; subject 470-678; similarity:fasta; with=UniProt:Q8UG26_AGRT5 (EMBL:AE008050); Agrobacterium tumefaciens (strain C58/ATCC 33970).; alaS; Alanyl-tRNA synthetase (AGR_C_2246p).; length=245; id 85.477; 241 aa overlap; query 1-241; subject 1-241; alanyl-tRNA synthetase, pseudogene 216596014256 Pfam match to entry PF01411.6 tRNA-synt_2c 216596014257 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 216596014258 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 216596014259 dimer interface [polypeptide binding]; other site 216596014260 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596014261 catalytic residue [active] 216596014262 Pfam match to entry PF00291.10 PALP 216596014263 anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451 216596014264 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 216596014265 short chain dehydrogenase; Provisional; Region: PRK06101 216596014266 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216596014267 NAD(P) binding site [chemical binding]; other site 216596014268 active site 216596014269 Pfam match to entry PF00106.11 adh_short 216596014270 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 216596014271 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 216596014272 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596014273 S-adenosylmethionine binding site [chemical binding]; other site 216596014274 Pfam match to entry PF02353.6 CMAS 216596014275 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 216596014276 Pfam match to entry PF07103.1 DUF1365 216596014277 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 216596014278 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 216596014279 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 216596014280 DNA photolyase; Region: DNA_photolyase; pfam00875 216596014281 Pfam match to entry PF03441.3 FAD_binding_7 216596014282 Pfam match to entry PF00875.7 DNA_photolyase 216596014283 1 probable transmembrane helix predicted at aa 11-33 216596014284 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 216596014285 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 216596014286 motif II; other site 216596014287 Pfam match to entry PF00702.10 Hydrolase 216596014288 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 216596014289 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 216596014290 [4Fe-4S] binding site [ion binding]; other site 216596014291 molybdopterin cofactor binding site; other site 216596014292 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 216596014293 molybdopterin cofactor binding site; other site 216596014294 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 216596014295 Pfam match to entry PF04324.3 Fer2_BFD 216596014296 Pfam match to entry PF01568.7 Molydop_binding 216596014297 Pfam match to entry PF00384.9 Molybdopterin 216596014298 Pfam match to entry PF04879.3 Molybdop_Fe4S4 216596014299 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 216596014300 [2Fe-2S] cluster binding site [ion binding]; other site 216596014301 Pfam match to entry PF00355.13 Rieske 216596014302 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 216596014303 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 216596014304 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 216596014305 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 216596014306 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 216596014307 Pfam match to entry PF01077.8 NIR_SIR 216596014308 Pfam match to entry PF03460.3 NIR_SIR_ferr 216596014309 Pfam match to entry PF04324.3 Fer2_BFD 216596014310 Pfam match to entry PF04324.3 Fer2_BFD 216596014311 Pfam match to entry PF00070.12 Pyr_redox 216596014312 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 216596014313 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596014314 putative substrate translocation pore; other site 216596014315 12 probable transmembrane helices predicted at aa 26-48, 61-83, 87-109, 116-138,148-170, 177-196, 227-249, 256-278, 293-315, 320-342,362-384 and 391-413 216596014316 NMT1-like family; Region: NMT1_2; pfam13379 216596014317 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 216596014318 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 216596014319 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596014320 active site 216596014321 phosphorylation site [posttranslational modification] 216596014322 intermolecular recognition site; other site 216596014323 ANTAR domain; Region: ANTAR; pfam03861 216596014324 Pfam match to entry PF03861.3 ANTAR 216596014325 Pfam match to entry PF00072.9 Response_reg 216596014326 Transcriptional regulators [Transcription]; Region: PurR; COG1609 216596014327 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216596014328 DNA binding site [nucleotide binding] 216596014329 domain linker motif; other site 216596014330 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 216596014331 putative ligand binding site [chemical binding]; other site 216596014332 putative dimerization interface [polypeptide binding]; other site 216596014333 Pfam match to entry PF00532.8 Peripla_BP_1 216596014334 Pfam match to entry PF00356.8 LacI 216596014335 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 216596014336 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 216596014337 putative ligand binding site [chemical binding]; other site 216596014338 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 216596014339 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 216596014340 Walker A/P-loop; other site 216596014341 ATP binding site [chemical binding]; other site 216596014342 Q-loop/lid; other site 216596014343 ABC transporter signature motif; other site 216596014344 Walker B; other site 216596014345 D-loop; other site 216596014346 H-loop/switch region; other site 216596014347 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 216596014348 Pfam match to entry PF00005.11 ABC_tran 216596014349 Pfam match to entry PF00005.11 ABC_tran 216596014350 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596014351 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216596014352 TM-ABC transporter signature motif; other site 216596014353 10 probable transmembrane helices predicted at aa 21-43, 53-72, 74-96, 101-123,128-150, 165-187, 218-240, 245-267, 272-294 and 299-321 216596014354 Pfam match to entry PF02653.5 BPD_transp_2 216596014355 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596014356 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216596014357 TM-ABC transporter signature motif; other site 216596014358 10 probable transmembrane helices predicted at aa 20-42, 57-74, 79-101, 106-128,133-155, 170-192, 224-246, 256-275, 277-299 and 304-322 216596014359 Pfam match to entry PF02653.5 BPD_transp_2 216596014360 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 216596014361 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 216596014362 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 216596014363 17 probable transmembrane helices predicted at aa 28-50, 65-87, 107-129, 144-163,170-192, 207-229, 250-272, 292-314, 334-356, 366-385,406-428, 438-460, 467-486, 496-518, 520-542, 552-574 and 587-609 216596014364 Pfam match to entry PF04290.2 DctQ 216596014365 Pfam match to entry PF06808.1 DctM 216596014366 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 216596014367 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 216596014368 Pfam match to entry PF03480.3 SBP_bac_7 216596014369 Transposase domain (DUF772); Region: DUF772; pfam05598 216596014370 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 216596014371 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 216596014372 Pfam match to entry PF01609.9 Transposase_11 216596014373 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 216596014374 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 216596014375 dimer interface [polypeptide binding]; other site 216596014376 decamer (pentamer of dimers) interface [polypeptide binding]; other site 216596014377 catalytic triad [active] 216596014378 Pfam match to entry PF00578.7 AhpC-TSA 216596014379 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 216596014380 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 216596014381 C-terminal domain interface [polypeptide binding]; other site 216596014382 GSH binding site (G-site) [chemical binding]; other site 216596014383 dimer interface [polypeptide binding]; other site 216596014384 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 216596014385 dimer interface [polypeptide binding]; other site 216596014386 N-terminal domain interface [polypeptide binding]; other site 216596014387 Pfam match to entry PF00043.11 GST_C 216596014388 Pfam match to entry PF02798.6 GST_N 216596014389 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 216596014390 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 216596014391 N-acetyl-D-glucosamine binding site [chemical binding]; other site 216596014392 catalytic residue [active] 216596014393 Pfam match to entry PF01464.7 SLT 216596014394 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 216596014395 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216596014396 NAD(P) binding site [chemical binding]; other site 216596014397 active site 216596014398 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216596014399 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 216596014400 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 216596014401 MOFRL family; Region: MOFRL; pfam05161 216596014402 Pfam match to entry PF05161.2 MOFRL 216596014403 hypothetical protein; Validated; Region: PRK09104 216596014404 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 216596014405 metal binding site [ion binding]; metal-binding site 216596014406 putative dimer interface [polypeptide binding]; other site 216596014407 Pfam match to entry PF01546.12 Peptidase_M20 216596014408 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 216596014409 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216596014410 Walker A/P-loop; other site 216596014411 ATP binding site [chemical binding]; other site 216596014412 Q-loop/lid; other site 216596014413 ABC transporter signature motif; other site 216596014414 Walker B; other site 216596014415 D-loop; other site 216596014416 H-loop/switch region; other site 216596014417 Pfam match to entry PF00005.11 ABC_tran 216596014418 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 216596014419 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596014420 dimer interface [polypeptide binding]; other site 216596014421 conserved gate region; other site 216596014422 putative PBP binding loops; other site 216596014423 ABC-ATPase subunit interface; other site 216596014424 7 probable transmembrane helices predicted at aa 10-32, 70-89, 99-119, 126-148,176-198, 205-224 and 239-261 216596014425 Pfam match to entry PF00528.10 BPD_transp_1 216596014426 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 216596014427 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596014428 dimer interface [polypeptide binding]; other site 216596014429 conserved gate region; other site 216596014430 putative PBP binding loops; other site 216596014431 ABC-ATPase subunit interface; other site 216596014432 Pfam match to entry PF00528.10 BPD_transp_1 216596014433 6 probable transmembrane helices predicted at aa 12-34, 59-81, 93-115, 142-164,185-207 and 241-263 216596014434 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 216596014435 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 216596014436 Pfam match to entry PF01547.11 SBP_bac_1 216596014437 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 216596014438 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 216596014439 active site 216596014440 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 216596014441 Pfam match to entry PF01979.7 Amidohydro_1 216596014442 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 216596014443 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216596014444 Walker A/P-loop; other site 216596014445 ATP binding site [chemical binding]; other site 216596014446 Q-loop/lid; other site 216596014447 ABC transporter signature motif; other site 216596014448 Walker B; other site 216596014449 D-loop; other site 216596014450 H-loop/switch region; other site 216596014451 Pfam match to entry PF00005.11 ABC_tran 216596014452 permease component of cationic ABC transporter, pseudogene; similarity:fasta; with=UniProt:Q9XD88_CORDI (EMBL:AF109162); Corynebacterium diphtheriae.; hmuU; HmuU.; length=350; id 32.464; 345 aa overlap; query 20-362; subject 19-348; similarity:fasta; with=UniProt:Q6D2K0_ERWCT (EMBL:BX950851); Erwinia carotovora (subsp. atroseptica) (Pectobacterium atrosepticum).; ABC transporter permease.; length=339; id 45.640; 344 aa overlap; query 20-361; subject 7-338 216596014453 Pfam match to entry PF01032.7 FecCD 216596014454 6 probable transmembrane helices predicted at aa 4-26, 39-61, 81-103, 132-154,169-186 and 193-215 216596014455 Pfam match to entry PF01032.7 FecCD 216596014456 1 probable transmembrane helix predicted at aa 21-43 216596014457 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 216596014458 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 216596014459 intersubunit interface [polypeptide binding]; other site 216596014460 Pfam match to entry PF01497.7 Peripla_BP_2 216596014461 1 probable transmembrane helix predicted at aa 27-46 216596014462 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 216596014463 hydroperoxidase II; Provisional; Region: katE; PRK11249 216596014464 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 216596014465 tetramer interface [polypeptide binding]; other site 216596014466 heme binding pocket [chemical binding]; other site 216596014467 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 216596014468 domain interactions; other site 216596014469 Pfam match to entry PF06628.1 Catalase-rel 216596014470 Pfam match to entry PF00199.8 Catalase 216596014471 4 probable transmembrane helices predicted at aa 27-49, 62-81, 113-135 and 261-283 216596014472 1 probable transmembrane helix predicted at aa 47-69 216596014473 KTSC domain; Region: KTSC; pfam13619 216596014474 DNA ligase, pseudogene; Similar to codons 200 to the C-terminus of Rhizobium meliloti (Sinorhizobium meliloti) DNA ligase. UniProt:Q930H2_RHIME (EMBL:AE007215) (346 aa); similarity:fasta; with=UniProt:Q930H2_RHIME (EMBL:AE007215); Rhizobium meliloti (Sinorhizobium meliloti).; DNA ligase.; length=346; id 50.350; 143 aa overlap; query 9-149; subject 200-340 216596014475 Pfam match to entry PF04679.4 DNA_ligase_A_C 216596014476 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 216596014477 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596014478 S-adenosylmethionine binding site [chemical binding]; other site 216596014479 Pfam match to entry PF01135.8 PCMT 216596014480 Protein of unknown function (DUF2497); Region: DUF2497; pfam10691 216596014481 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 216596014482 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 216596014483 HIGH motif; other site 216596014484 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 216596014485 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 216596014486 active site 216596014487 KMSKS motif; other site 216596014488 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 216596014489 tRNA binding surface [nucleotide binding]; other site 216596014490 anticodon binding site; other site 216596014491 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 216596014492 Pfam match to entry PF00133.8 tRNA-synt_1 216596014493 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 216596014494 Pfam match to entry PF03349.5 Toluene_X 216596014495 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 216596014496 Sel1-like repeats; Region: SEL1; smart00671 216596014497 Sel1-like repeats; Region: SEL1; smart00671 216596014498 1 probable transmembrane helix predicted at aa 21-40 216596014499 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 216596014500 putative catalytic site [active] 216596014501 putative phosphate binding site [ion binding]; other site 216596014502 active site 216596014503 metal binding site A [ion binding]; metal-binding site 216596014504 DNA binding site [nucleotide binding] 216596014505 putative AP binding site [nucleotide binding]; other site 216596014506 putative metal binding site B [ion binding]; other site 216596014507 Pfam match to entry PF03372.6 Exo_endo_phos 216596014508 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 216596014509 Pfam match to entry PF01521.7 HesB 216596014510 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 216596014511 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 216596014512 Zn2+ binding site [ion binding]; other site 216596014513 Mg2+ binding site [ion binding]; other site 216596014514 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 216596014515 Pfam match to entry PF01966.8 HD 216596014516 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 216596014517 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 216596014518 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 216596014519 active site 216596014520 HIGH motif; other site 216596014521 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 216596014522 KMSK motif region; other site 216596014523 tRNA binding surface [nucleotide binding]; other site 216596014524 DALR anticodon binding domain; Region: DALR_1; smart00836 216596014525 anticodon binding site; other site 216596014526 Pfam match to entry PF03485.5 Arg_tRNA_synt_N 216596014527 Pfam match to entry PF00750.8 tRNA-synt_1d 216596014528 Pfam match to entry PF05746.3 tRNA-synt_1d_C 216596014529 Sporulation related domain; Region: SPOR; pfam05036 216596014530 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 216596014531 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 216596014532 Pfam match to entry PF00933.10 Glyco_hydro_3 216596014533 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 216596014534 Pfam match to entry PF02616.4 DUF173 216596014535 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 216596014536 Pfam match to entry PF04079.5 DUF387 216596014537 twin arginine translocase protein A; Provisional; Region: tatA; PRK00720 216596014538 Pfam match to entry PF02416.5 MttA_Hcf106 216596014539 1 probable transmembrane helix predicted at aa 4-21 216596014540 sec-independent translocase; Provisional; Region: PRK00708 216596014541 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 216596014542 Pfam match to entry PF02416.5 MttA_Hcf106 216596014543 1 probable transmembrane helix predicted at aa 4-21 216596014544 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 216596014545 Pfam match to entry PF00902.7 TatC 216596014546 6 probable transmembrane helices predicted at aa 27-49, 83-105, 117-139, 176-198,210-224 and 228-250 216596014547 seryl-tRNA synthetase; Provisional; Region: PRK05431 216596014548 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 216596014549 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 216596014550 dimer interface [polypeptide binding]; other site 216596014551 active site 216596014552 motif 1; other site 216596014553 motif 2; other site 216596014554 motif 3; other site 216596014555 Pfam match to entry PF02403.6 Seryl_tRNA_N 216596014556 Pfam match to entry PF00587.10 tRNA-synt_2b 216596014557 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 216596014558 Pfam match to entry PF01975.6 SurE 216596014559 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 216596014560 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 216596014561 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596014562 S-adenosylmethionine binding site [chemical binding]; other site 216596014563 Pfam match to entry PF01135.8 PCMT 216596014564 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 216596014565 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 216596014566 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 216596014567 Peptidase family M23; Region: Peptidase_M23; pfam01551 216596014568 Pfam match to entry PF01476.8 LysM 216596014569 Pfam match to entry PF01476.8 LysM 216596014570 Pfam match to entry PF01551.6 Peptidase_M23 216596014571 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 216596014572 Protein of unknown function (DUF815); Region: DUF815; pfam05673 216596014573 Walker A motif; other site 216596014574 ATP binding site [chemical binding]; other site 216596014575 Walker B motif; other site 216596014576 Pfam match to entry PF05673.1 DUF815 216596014577 Preprotein translocase subunit YajC [Intracellular trafficking and secretion]; Region: YajC; COG1862 216596014578 1 probable transmembrane helix predicted at aa 20-41 216596014579 Pfam match to entry PF02699.4 YajC 216596014580 bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726 216596014581 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 216596014582 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 216596014583 Protein export membrane protein; Region: SecD_SecF; pfam02355 216596014584 12 probable transmembrane helices predicted at aa 7-29, 364-386, 391-413, 417-439,460-482, 497-519, 549-571, 664-686, 693-715, 719-741,767-789 and 799-821 216596014585 Pfam match to entry PF07549.1 Sec_GG 216596014586 Pfam match to entry PF02355.6 SecD_SecF 216596014587 Pfam match to entry PF07549.1 Sec_GG 216596014588 Pfam match to entry PF02355.6 SecD_SecF 216596014589 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 216596014590 Pfam match to entry PF04635.2 DUF598 216596014591 Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562 216596014592 substrate binding pocket [chemical binding]; other site 216596014593 substrate-Mg2+ binding site; other site 216596014594 aspartate-rich region 1; other site 216596014595 aspartate-rich region 2; other site 216596014596 Pfam match to entry PF00494.8 SQS_PSY 216596014597 1 probable transmembrane helix predicted at aa 2-24 216596014598 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 216596014599 Glucose inhibited division protein A; Region: GIDA; pfam01134 216596014600 Pfam match to entry PF01134.9 GIDA 216596014601 Predicted membrane protein (DUF2157); Region: DUF2157; cl10480 216596014602 11 probable transmembrane helices predicted at aa 75-97, 104-126, 130-152, 165-187,207-229, 236-253, 258-280, 287-309, 314-333, 340-359 and 364-386 216596014603 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 216596014604 1 probable transmembrane helix predicted at aa 13-35 216596014605 trigger factor; Provisional; Region: tig; PRK01490 216596014606 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 216596014607 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 216596014608 Pfam match to entry PF05697.2 Trigger_N 216596014609 Pfam match to entry PF00254.12 FKBP_C 216596014610 Pfam match to entry PF05698.2 Trigger_C 216596014611 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 216596014612 B12-binding domain/radical SAM domain protein, MJ_1487 family; Region: B12_SAM_MJ_1487; TIGR04013 216596014613 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 216596014614 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 216596014615 FeS/SAM binding site; other site 216596014616 Pfam match to entry PF04055.4 Radical_SAM 216596014617 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 216596014618 putative catalytic site [active] 216596014619 putative metal binding site [ion binding]; other site 216596014620 putative phosphate binding site [ion binding]; other site 216596014621 Pfam match to entry PF03372.6 Exo_endo_phos 216596014622 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 216596014623 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 216596014624 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 216596014625 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 216596014626 Pfam match to entry PF02852.6 Pyr_redox_dim 216596014627 Pfam match to entry PF00070.12 Pyr_redox 216596014628 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 216596014629 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 216596014630 phosphate binding site [ion binding]; other site 216596014631 Pfam match to entry PF01070.7 FMN_dh 216596014632 hypothetical protein; Reviewed; Region: PRK00024 216596014633 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 216596014634 MPN+ (JAMM) motif; other site 216596014635 Zinc-binding site [ion binding]; other site 216596014636 Pfam match to entry PF04002.4 RadC 216596014637 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 216596014638 active site 216596014639 Pfam match to entry PF00557.8 Peptidase_M24 216596014640 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216596014641 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216596014642 Pfam match to entry PF00440.8 TetR_N 216596014643 1 probable transmembrane helix predicted at aa 20-42 216596014644 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 216596014645 2 probable transmembrane helices predicted at aa 5-24 and 55-77 216596014646 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 216596014647 Pfam match to entry PF03652.4 UPF0081 216596014648 metal-dependent hydrolase; Provisional; Region: PRK00685 216596014649 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 216596014650 Pfam match to entry PF00753.12 Lactamase_B 216596014651 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 216596014652 Pfam match to entry PF02686.4 Glu-tRNAGln 216596014653 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 216596014654 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 216596014655 Pfam match to entry PF01425.8 Amidase 216596014656 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 216596014657 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216596014658 Coenzyme A binding pocket [chemical binding]; other site 216596014659 Pfam match to entry PF00583.9 Acetyltransf_1 216596014660 hypothetical protein; Provisional; Region: PRK13687 216596014661 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 216596014662 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216596014663 Coenzyme A binding pocket [chemical binding]; other site 216596014664 Pfam match to entry PF00583.9 Acetyltransf_1 216596014665 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 216596014666 3 probable transmembrane helices predicted at aa 7-26, 41-58 and 71-93 216596014667 Pfam match to entry PF06961.1 DUF1294 216596014668 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 216596014669 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 216596014670 GatB domain; Region: GatB_Yqey; smart00845 216596014671 Pfam match to entry PF02934.4 GatB_N 216596014672 Pfam match to entry PF01162.8 GatB 216596014673 Pfam match to entry PF02637.5 GatB_Yqey 216596014674 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 216596014675 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216596014676 Coenzyme A binding pocket [chemical binding]; other site 216596014677 Pfam match to entry PF00583.9 Acetyltransf_1 216596014678 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 216596014679 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216596014680 Coenzyme A binding pocket [chemical binding]; other site 216596014681 Pfam match to entry PF00583.9 Acetyltransf_1 216596014682 NADH dehydrogenase; Validated; Region: PRK08183 216596014683 Pfam match to entry PF05071.6 Complex1_17_2kD 216596014684 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4765 216596014685 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 216596014686 Pfam match to entry PF03588.4 Leu_Phe_trans 216596014687 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 216596014688 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 216596014689 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 216596014690 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 216596014691 Pfam match to entry PF02785.5 Biotin_carb_C 216596014692 Pfam match to entry PF02786.4 CPSase_L_D2 216596014693 Pfam match to entry PF00289.9 CPSase_L_chain 216596014694 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 216596014695 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 216596014696 carboxyltransferase (CT) interaction site; other site 216596014697 biotinylation site [posttranslational modification]; other site 216596014698 Pfam match to entry PF00364.9 Biotin_lipoyl 216596014699 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 216596014700 Dehydroquinase class II; Region: DHquinase_II; pfam01220 216596014701 trimer interface [polypeptide binding]; other site 216596014702 active site 216596014703 dimer interface [polypeptide binding]; other site 216596014704 Pfam match to entry PF01220.7 DHquinase_II 216596014705 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 216596014706 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 216596014707 catalytic residues [active] 216596014708 Pfam match to entry PF01323.9 DSBA 216596014709 aspartate aminotransferase; Provisional; Region: PRK05764 216596014710 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216596014711 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596014712 homodimer interface [polypeptide binding]; other site 216596014713 catalytic residue [active] 216596014714 Pfam match to entry PF00155.8 Aminotran_1_2 216596014715 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 216596014716 1 probable transmembrane helix predicted at aa 89-111 216596014717 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 216596014718 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 216596014719 Pfam match to entry PF07167.2 PhaC_N 216596014720 aminotransferase; Validated; Region: PRK09148 216596014721 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216596014722 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596014723 homodimer interface [polypeptide binding]; other site 216596014724 catalytic residue [active] 216596014725 Pfam match to entry PF00155.8 Aminotran_1_2 216596014726 homoserine dehydrogenase; Provisional; Region: PRK06349 216596014727 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 216596014728 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 216596014729 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 216596014730 Pfam match to entry PF03447.4 NAD_binding_3 216596014731 Pfam match to entry PF00742.8 Homoserine_dh 216596014732 Pfam match to entry PF01842.8 ACT 216596014733 1 probable transmembrane helix predicted at aa 62-84 216596014734 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 216596014735 DHH family; Region: DHH; pfam01368 216596014736 DHHA1 domain; Region: DHHA1; pfam02272 216596014737 Pfam match to entry PF01368.8 DHH 216596014738 Pfam match to entry PF02272.6 DHHA1 216596014739 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 216596014740 Peptidase M15; Region: Peptidase_M15_3; cl01194 216596014741 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216596014742 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 216596014743 dimer interface [polypeptide binding]; other site 216596014744 active site 216596014745 metal binding site [ion binding]; metal-binding site 216596014746 glutathione binding site [chemical binding]; other site 216596014747 Pfam match to entry PF00903.11 Glyoxalase 216596014748 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 216596014749 DNA-binding site [nucleotide binding]; DNA binding site 216596014750 RNA-binding motif; other site 216596014751 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 216596014752 DNA-binding site [nucleotide binding]; DNA binding site 216596014753 RNA-binding motif; other site 216596014754 Pfam match to entry PF00313.8 CSD 216596014755 Pfam match to entry PF00313.8 CSD 216596014756 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 216596014757 1 probable transmembrane helix predicted at aa 4-26 216596014758 Pfam match to entry PF02643.4 DUF192 216596014759 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 216596014760 Pfam match to entry PF04800.2 ETC_C1_NDUFA4 216596014761 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 216596014762 synthetase active site [active] 216596014763 NTP binding site [chemical binding]; other site 216596014764 metal binding site [ion binding]; metal-binding site 216596014765 Pfam match to entry PF04607.3 RelA_SpoT 216596014766 CRISPR/Cas system-associated protein Cas3/Cas2; Region: Cas3_Cas2_I-F; cd09673 216596014767 4 probable transmembrane helices predicted at aa 135-154, 174-196, 216-238 and 253-272 216596014768 Peptidase family M54, also called archaemetzincins or archaelysins; Region: Peptidase_M54; cl17349 216596014769 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 216596014770 active site 216596014771 polymerase, pseudogene; similarity:fasta; with=UniProt:Q89W32_BRAJA (EMBL:BA000040); Bradyrhizobium japonicum.; dinP; DNA-damage-inducible protein.; length=366; id 84.946; 93 aa overlap; query 5-97; subject 10-99 216596014772 Pfam match to entry PF00817.8 IMS 216596014773 Uncharacterized conserved protein [Function unknown]; Region: COG4544 216596014774 DNA Polymerase Y-family; Region: PolY_like; cd03468 216596014775 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 216596014776 DNA binding site [nucleotide binding] 216596014777 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 216596014778 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 216596014779 putative active site [active] 216596014780 putative PHP Thumb interface [polypeptide binding]; other site 216596014781 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 216596014782 generic binding surface I; other site 216596014783 generic binding surface II; other site 216596014784 Pfam match to entry PF02231.5 PHP_N 216596014785 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 216596014786 3 probable transmembrane helices predicted at aa 7-29, 60-82 and 94-116 216596014787 Uncharacterized conserved protein [Function unknown]; Region: COG2135 216596014788 Pfam match to entry PF02586.4 DUF159 216596014789 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 216596014790 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 216596014791 Catalytic site; other site 216596014792 1 probable transmembrane helix predicted at aa 117-139 216596014793 5 probable transmembrane helices predicted at aa 7-29, 60-82, 94-111, 116-135 and 156-178 216596014794 1 probable transmembrane helix predicted at aa 40-57 216596014795 2 probable transmembrane helices predicted at aa 29-51 and 61-78 216596014796 3 probable transmembrane helices predicted at aa 41-60, 73-95 and 110-132 216596014797 HerA helicase [Replication, recombination, and repair]; Region: COG0433 216596014798 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 216596014799 Part of AAA domain; Region: AAA_19; pfam13245 216596014800 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 216596014801 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 216596014802 AAA domain; Region: AAA_12; pfam13087 216596014803 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 216596014804 putative active site [active] 216596014805 Transposase; Region: HTH_Tnp_1; pfam01527 216596014806 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 216596014807 Pfam match to entry PF01527.7 Transposase_8 216596014808 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 216596014809 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 216596014810 Pfam match to entry PF05717.2 Transposase_34 216596014811 transposase-related protein,pseudogene; N-terminus to codon 454 is similar to N-terminus to codon 445 of Rhizobium etli yi14a-iii hypothetical protein yi14a-iii. UniProt:Q8KL41_RHIET (EMBL:U80928) (510 aa); similarity:fasta; with=UniProt:Q8KL41_RHIET (EMBL:U80928); Rhizobium etli.; yi14a-III; Hypothetical protein yi14a-III.; length=510; id 84.071; 452 aa overlap; query 1-452; subject 1-445 216596014812 Pfam match to entry PF03050.4 Transposase_25 216596014813 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 216596014814 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 216596014815 catalytic residues [active] 216596014816 catalytic nucleophile [active] 216596014817 Recombinase; Region: Recombinase; pfam07508 216596014818 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 216596014819 Pfam match to entry PF07508.1 Recombinase 216596014820 Pfam match to entry PF00239.10 Resolvase 216596014821 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 216596014822 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 216596014823 putative homodimer interface [polypeptide binding]; other site 216596014824 putative DNA binding site [nucleotide binding]; other site 216596014825 Pfam match to entry PF02735.5 Ku 216596014826 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 216596014827 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 216596014828 putative DNA binding site [nucleotide binding]; other site 216596014829 putative homodimer interface [polypeptide binding]; other site 216596014830 Pfam match to entry PF02735.5 Ku 216596014831 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 216596014832 1 probable transmembrane helix predicted at aa 621-643 216596014833 Protein of unknown function (DUF982); Region: DUF982; pfam06169 216596014834 Pfam match to entry PF06169.1 DUF982 216596014835 Transposase; Region: DEDD_Tnp_IS110; pfam01548 216596014836 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 216596014837 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 216596014838 Pfam match to entry PF02371.5 Transposase_20 216596014839 2 probable transmembrane helices predicted at aa 15-37 and 88-107 216596014840 Nuclease-related domain; Region: NERD; pfam08378 216596014841 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 216596014842 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 216596014843 active site 216596014844 metal binding site [ion binding]; metal-binding site 216596014845 Pfam match to entry PF00149.12 Metallophos 216596014846 Predicted ATPase [General function prediction only]; Region: COG5293 216596014847 Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088 216596014848 1 probable transmembrane helix predicted at aa 15-37 216596014849 PLD-like domain; Region: PLDc_2; pfam13091 216596014850 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 216596014851 putative active site [active] 216596014852 catalytic site [active] 216596014853 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176 216596014854 putative homodimer interface [polypeptide binding]; other site 216596014855 putative active site [active] 216596014856 catalytic site [active] 216596014857 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 216596014858 multiple promoter invertase; Provisional; Region: mpi; PRK13413 216596014859 catalytic residues [active] 216596014860 catalytic nucleophile [active] 216596014861 Presynaptic Site I dimer interface [polypeptide binding]; other site 216596014862 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 216596014863 Synaptic Flat tetramer interface [polypeptide binding]; other site 216596014864 Synaptic Site I dimer interface [polypeptide binding]; other site 216596014865 DNA binding site [nucleotide binding] 216596014866 Pfam match to entry PF00239.10 Resolvase 216596014867 CHAT domain; Region: CHAT; pfam12770 216596014868 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 216596014869 putative catalytic site [active] 216596014870 putative metal binding site [ion binding]; other site 216596014871 putative phosphate binding site [ion binding]; other site 216596014872 conserved hypothetical protein, pseudogene; N-terminus is similar to N-terminus to codon 250 of Anabaena sp. (strain PCC 7120) all3488 protein. UniProt:Q8YRG0_ANASP (EMBL:BA000019) (291 aa); similarity:fasta; with=UniProt:Q8YRG0_ANASP (EMBL:BA000019); Anabaena sp. (strain PCC 7120).; All3488 protein.; length=291; id 48.980; 245 aa overlap; query 2-243; subject 3-246 216596014873 Caspase domain; Region: Peptidase_C14; pfam00656 216596014874 Pfam match to entry PF00656.9 Peptidase_C14 216596014875 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 216596014876 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 216596014877 oligomeric interface; other site 216596014878 putative active site [active] 216596014879 homodimer interface [polypeptide binding]; other site 216596014880 Pfam match to entry PF01850.8 PIN 216596014881 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216596014882 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 216596014883 Walker A motif; other site 216596014884 ATP binding site [chemical binding]; other site 216596014885 Walker B motif; other site 216596014886 arginine finger; other site 216596014887 Peptidase family M41; Region: Peptidase_M41; pfam01434 216596014888 Pfam match to entry PF00004.12 AAA 216596014889 Pfam match to entry PF01434.6 Peptidase_M41 216596014890 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 216596014891 Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404 216596014892 putative active site [active] 216596014893 putative metal binding site [ion binding]; other site 216596014894 Pfam match to entry PF00149.12 Metallophos 216596014895 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 216596014896 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216596014897 non-specific DNA binding site [nucleotide binding]; other site 216596014898 salt bridge; other site 216596014899 sequence-specific DNA binding site [nucleotide binding]; other site 216596014900 Pfam match to entry PF01381.9 HTH_3 216596014901 Domain of unknown function (DUF955); Region: DUF955; pfam06114 216596014902 Pfam match to entry PF06114.2 DUF955 216596014903 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 216596014904 active site 216596014905 NTP binding site [chemical binding]; other site 216596014906 metal binding triad [ion binding]; metal-binding site 216596014907 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 216596014908 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216596014909 Walker B motif; other site 216596014910 arginine finger; other site 216596014911 Pfam match to entry PF00004.12 AAA 216596014912 Integrase core domain; Region: rve; pfam00665 216596014913 Protein of unknown function (DUF2984); Region: DUF2984; cl12752 216596014914 Pfam match to entry PF00665.10 rve 216596014915 AAA domain; Region: AAA_22; pfam13401 216596014916 Bacterial TniB protein; Region: TniB; pfam05621 216596014917 TniQ; Region: TniQ; pfam06527 216596014918 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 216596014919 Protein of unknown function (DUF982); Region: DUF982; pfam06169 216596014920 Pfam match to entry PF06169.1 DUF982 216596014921 conserved hypothetical protein, pseudogene; Similar to N-terminus to codon 83 of Rhodopseudomonas palustris beta-lactamase precursor. UniProt:Q6N609_RHOPA (EMBL:BX572602) (430 aa); similarity:fasta; with=UniProt:Q6N609_RHOPA (EMBL:BX572602); Rhodopseudomonas palustris.; Beta-lactamase precursor.; length=430; id 41.791; 67 aa overlap; query 11-74; subject 19-82 216596014922 Signal peptide predicted for RL2197 by SignalP 2.0 HMM (Signal peptide probabilty 0.781) with cleavage site probability 0.667 between residues 30 and 31 216596014923 Domain of unknown function (DUF3597); Region: DUF3597; pfam12200 216596014924 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 216596014925 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 216596014926 Walker A/P-loop; other site 216596014927 ATP binding site [chemical binding]; other site 216596014928 Q-loop/lid; other site 216596014929 ABC transporter signature motif; other site 216596014930 Walker B; other site 216596014931 D-loop; other site 216596014932 H-loop/switch region; other site 216596014933 Pfam match to entry PF00005.11 ABC_tran 216596014934 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 216596014935 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596014936 dimer interface [polypeptide binding]; other site 216596014937 conserved gate region; other site 216596014938 putative PBP binding loops; other site 216596014939 ABC-ATPase subunit interface; other site 216596014940 Pfam match to entry PF00528.10 BPD_transp_1 216596014941 8 probable transmembrane helices predicted at aa 41-63, 114-133, 140-162, 177-199,220-242, 247-269, 306-328 and 343-365 216596014942 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 216596014943 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596014944 conserved gate region; other site 216596014945 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596014946 dimer interface [polypeptide binding]; other site 216596014947 conserved gate region; other site 216596014948 putative PBP binding loops; other site 216596014949 ABC-ATPase subunit interface; other site 216596014950 Pfam match to entry PF00528.10 BPD_transp_1 216596014951 8 probable transmembrane helices predicted at aa 29-48, 95-117, 138-160, 190-212,225-247, 262-284, 340-359 and 369-391 216596014952 Pfam match to entry PF03929.4 PepSY_TM 216596014953 Pfam match to entry PF03929.4 PepSY_TM 216596014954 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 216596014955 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 216596014956 substrate binding pocket [chemical binding]; other site 216596014957 membrane-bound complex binding site; other site 216596014958 hinge residues; other site 216596014959 1 probable transmembrane helix predicted at aa 54-76 216596014960 cystathionine beta-lyase; Provisional; Region: PRK05967 216596014961 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 216596014962 homodimer interface [polypeptide binding]; other site 216596014963 substrate-cofactor binding pocket; other site 216596014964 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596014965 catalytic residue [active] 216596014966 Pfam match to entry PF01053.8 Cys_Met_Meta_PP 216596014967 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 216596014968 salicylate hydroxylase; Provisional; Region: PRK08163 216596014969 Pfam match to entry PF01360.9 Monooxygenase 216596014970 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391 216596014971 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216596014972 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 216596014973 Pfam match to entry PF00561.8 Abhydrolase_1 216596014974 serine acetyltransferase; Provisional; Region: cysE; PRK11132 216596014975 Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971 216596014976 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 216596014977 trimer interface [polypeptide binding]; other site 216596014978 active site 216596014979 substrate binding site [chemical binding]; other site 216596014980 CoA binding site [chemical binding]; other site 216596014981 Pfam match to entry PF06426.1 SATase_N 216596014982 Pfam match to entry PF00132.9 Hexapep 216596014983 Pfam match to entry PF00132.9 Hexapep 216596014984 Protein of unknown function (DUF3126); Region: DUF3126; pfam11324 216596014985 Phasin protein; Region: Phasin_2; pfam09361 216596014986 Uncharacterized conserved protein [Function unknown]; Region: COG2127 216596014987 Pfam match to entry PF02617.4 ClpS 216596014988 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 216596014989 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216596014990 Walker A motif; other site 216596014991 ATP binding site [chemical binding]; other site 216596014992 Walker B motif; other site 216596014993 arginine finger; other site 216596014994 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216596014995 Walker A motif; other site 216596014996 ATP binding site [chemical binding]; other site 216596014997 Walker B motif; other site 216596014998 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 216596014999 Pfam match to entry PF02861.5 Clp_N 216596015000 Pfam match to entry PF00004.12 AAA 216596015001 Pfam match to entry PF00004.12 AAA 216596015002 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 216596015003 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 216596015004 HIT family signature motif; other site 216596015005 catalytic residue [active] 216596015006 Pfam match to entry PF01230.10 HIT 216596015007 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146 216596015008 Protein of unknown function, DUF482; Region: DUF482; pfam04339 216596015009 Pfam match to entry PF04339.2 DUF482 216596015010 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_3; cd08585 216596015011 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 216596015012 putative active site [active] 216596015013 catalytic site [active] 216596015014 putative metal binding site [ion binding]; other site 216596015015 Pfam match to entry PF03009.6 GDPD 216596015016 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 216596015017 homotrimer interaction site [polypeptide binding]; other site 216596015018 putative active site [active] 216596015019 Pfam match to entry PF01042.8 Ribonuc_L-PSP 216596015020 Domain of unknown function (DUF1849); Region: DUF1849; pfam08904 216596015021 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 216596015022 rRNA interaction site [nucleotide binding]; other site 216596015023 S8 interaction site; other site 216596015024 putative laminin-1 binding site; other site 216596015025 Pfam match to entry PF00318.7 Ribosomal_S2 216596015026 elongation factor Ts; Provisional; Region: tsf; PRK09377 216596015027 UBA/TS-N domain; Region: UBA; pfam00627 216596015028 Elongation factor TS; Region: EF_TS; pfam00889 216596015029 Elongation factor TS; Region: EF_TS; pfam00889 216596015030 Pfam match to entry PF00627.13 UBA 216596015031 Pfam match to entry PF00889.8 EF_TS 216596015032 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 216596015033 putative nucleotide binding site [chemical binding]; other site 216596015034 uridine monophosphate binding site [chemical binding]; other site 216596015035 homohexameric interface [polypeptide binding]; other site 216596015036 Pfam match to entry PF00696.12 AA_kinase 216596015037 ribosome recycling factor; Reviewed; Region: frr; PRK00083 216596015038 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 216596015039 hinge region; other site 216596015040 Pfam match to entry PF01765.7 RRF 216596015041 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14834 216596015042 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 216596015043 catalytic residue [active] 216596015044 putative FPP diphosphate binding site; other site 216596015045 putative FPP binding hydrophobic cleft; other site 216596015046 dimer interface [polypeptide binding]; other site 216596015047 putative IPP diphosphate binding site; other site 216596015048 Pfam match to entry PF01255.9 Prenyltransf 216596015049 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 216596015050 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 216596015051 Pfam match to entry PF01148.9 CTP_transf_1 216596015052 7 probable transmembrane helices predicted at aa 13-35, 55-77, 79-98, 103-121,128-150, 170-192 and 244-266 216596015053 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 216596015054 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 216596015055 active site 216596015056 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 216596015057 protein binding site [polypeptide binding]; other site 216596015058 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 216596015059 putative substrate binding region [chemical binding]; other site 216596015060 4 probable transmembrane helices predicted at aa 7-29, 118-140, 298-320 and 351-373 216596015061 Pfam match to entry PF02163.9 Peptidase_M50 216596015062 Pfam match to entry PF00595.8 PDZ 216596015063 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 216596015064 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 216596015065 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 216596015066 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 216596015067 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 216596015068 Surface antigen; Region: Bac_surface_Ag; pfam01103 216596015069 Pfam match to entry PF07244.1 Surf_Ag_VNR 216596015070 Pfam match to entry PF07244.1 Surf_Ag_VNR 216596015071 Pfam match to entry PF07244.1 Surf_Ag_VNR 216596015072 Pfam match to entry PF07244.1 Surf_Ag_VNR 216596015073 Pfam match to entry PF07244.1 Surf_Ag_VNR 216596015074 Pfam match to entry PF01103.10 Bac_surface_Ag 216596015075 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 216596015076 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 216596015077 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 216596015078 trimer interface [polypeptide binding]; other site 216596015079 active site 216596015080 UDP-GlcNAc binding site [chemical binding]; other site 216596015081 lipid binding site [chemical binding]; lipid-binding site 216596015082 Pfam match to entry PF04613.2 LpxD 216596015083 Pfam match to entry PF00132.9 Hexapep 216596015084 Pfam match to entry PF00132.9 Hexapep 216596015085 Pfam match to entry PF00132.9 Hexapep 216596015086 Pfam match to entry PF00132.9 Hexapep 216596015087 Pfam match to entry PF00132.9 Hexapep 216596015088 Pfam match to entry PF00132.9 Hexapep 216596015089 Pfam match to entry PF00132.9 Hexapep 216596015090 Pfam match to entry PF00132.9 Hexapep 216596015091 Pfam match to entry PF00132.9 Hexapep 216596015092 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 216596015093 Pfam match to entry PF03061.8 4HBT 216596015094 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 216596015095 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 216596015096 active site 216596015097 Pfam match to entry PF00132.9 Hexapep 216596015098 Pfam match to entry PF00132.9 Hexapep 216596015099 Pfam match to entry PF00132.9 Hexapep 216596015100 Pfam match to entry PF00132.9 Hexapep 216596015101 Pfam match to entry PF00132.9 Hexapep 216596015102 Pfam match to entry PF00132.9 Hexapep 216596015103 Pfam match to entry PF00132.9 Hexapep 216596015104 Pfam match to entry PF00132.9 Hexapep 216596015105 Protein of unknown function (DUF1009); Region: DUF1009; cl09182 216596015106 Pfam match to entry PF06230.1 DUF1009 216596015107 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 216596015108 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 216596015109 Pfam match to entry PF02684.5 LpxB 216596015110 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 216596015111 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 216596015112 dimer interface [polypeptide binding]; other site 216596015113 active site 216596015114 citrylCoA binding site [chemical binding]; other site 216596015115 NADH binding [chemical binding]; other site 216596015116 cationic pore residues; other site 216596015117 oxalacetate/citrate binding site [chemical binding]; other site 216596015118 coenzyme A binding site [chemical binding]; other site 216596015119 catalytic triad [active] 216596015120 Pfam match to entry PF00285.10 Citrate_synt 216596015121 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 216596015122 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 216596015123 Competence protein; Region: Competence; pfam03772 216596015124 12 probable transmembrane helices predicted at aa 4-21, 89-108, 113-130, 340-362,377-399, 419-436, 440-462, 483-505, 520-542, 549-566,581-599 and 606-623 216596015125 Pfam match to entry PF03772.4 Competence 216596015126 LexA repressor; Validated; Region: PRK00215 216596015127 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 216596015128 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 216596015129 Catalytic site [active] 216596015130 Pfam match to entry PF00717.8 Peptidase_S24 216596015131 Pfam match to entry PF01726.6 LexA_DNA_bind 216596015132 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 216596015133 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 216596015134 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 216596015135 Pfam match to entry PF00793.9 DAHP_synth_1 216596015136 enolase; Provisional; Region: eno; PRK00077 216596015137 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 216596015138 dimer interface [polypeptide binding]; other site 216596015139 metal binding site [ion binding]; metal-binding site 216596015140 substrate binding pocket [chemical binding]; other site 216596015141 Pfam match to entry PF03952.3 Enolase_N 216596015142 Pfam match to entry PF00113.9 Enolase_C 216596015143 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 216596015144 Septum formation initiator; Region: DivIC; pfam04977 216596015145 1 probable transmembrane helix predicted at aa 12-34 216596015146 Pfam match to entry PF04977.3 DivIC 216596015147 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 216596015148 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 216596015149 tetramer interface [polypeptide binding]; other site 216596015150 TPP-binding site [chemical binding]; other site 216596015151 heterodimer interface [polypeptide binding]; other site 216596015152 phosphorylation loop region [posttranslational modification] 216596015153 Pfam match to entry PF00676.8 E1_dh 216596015154 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 216596015155 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 216596015156 E3 interaction surface; other site 216596015157 lipoyl attachment site [posttranslational modification]; other site 216596015158 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 216596015159 alpha subunit interface [polypeptide binding]; other site 216596015160 TPP binding site [chemical binding]; other site 216596015161 heterodimer interface [polypeptide binding]; other site 216596015162 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 216596015163 Pfam match to entry PF00364.9 Biotin_lipoyl 216596015164 Pfam match to entry PF02779.8 Transket_pyr 216596015165 Pfam match to entry PF02780.6 Transketolase_C 216596015166 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 216596015167 E3 interaction surface; other site 216596015168 lipoyl attachment site [posttranslational modification]; other site 216596015169 e3 binding domain; Region: E3_binding; pfam02817 216596015170 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 216596015171 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 216596015172 Pfam match to entry PF00364.9 Biotin_lipoyl 216596015173 Pfam match to entry PF02817.4 E3_binding 216596015174 Pfam match to entry PF00198.10 2-oxoacid_dh 216596015175 SGNH_hydrolase subfamily, similar to arylesterase (7-aminocephalosporanic acid-deacetylating enzyme) of A. tumefaciens. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of...; Region: SGNH_arylesterase_like; cd01839 216596015176 active site 216596015177 catalytic triad [active] 216596015178 oxyanion hole [active] 216596015179 Pfam match to entry PF00657.10 Lipase_GDSL 216596015180 Pfam match to entry PF00583.9 Acetyltransf_1 216596015181 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 216596015182 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 216596015183 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 216596015184 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 216596015185 Pfam match to entry PF00070.12 Pyr_redox 216596015186 Pfam match to entry PF02852.6 Pyr_redox_dim 216596015187 3 probable transmembrane helices predicted at aa 27-49, 56-78 and 83-105 216596015188 Pfam match to entry PF04226.2 Transgly_assoc 216596015189 Predicted membrane protein [Function unknown]; Region: COG2261 216596015190 3 probable transmembrane helices predicted at aa 10-27, 34-56 and 61-83 216596015191 Pfam match to entry PF04226.2 Transgly_assoc 216596015192 lipoyl synthase; Provisional; Region: PRK05481 216596015193 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 216596015194 FeS/SAM binding site; other site 216596015195 Pfam match to entry PF04055.4 Radical_SAM 216596015196 topology modulation protein; Reviewed; Region: PRK08118 216596015197 AAA domain; Region: AAA_17; pfam13207 216596015198 topology modulation protein; Reviewed; Region: PRK08118 216596015199 AAA domain; Region: AAA_17; pfam13207 216596015200 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 216596015201 putative coenzyme Q binding site [chemical binding]; other site 216596015202 Pfam match to entry PF03654.3 ARPF 216596015203 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 216596015204 Pfam match to entry PF02464.5 CinA 216596015205 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 216596015206 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 216596015207 substrate binding site; other site 216596015208 dimer interface; other site 216596015209 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 216596015210 homotrimer interaction site [polypeptide binding]; other site 216596015211 zinc binding site [ion binding]; other site 216596015212 CDP-binding sites; other site 216596015213 Pfam match to entry PF02542.4 YgbB 216596015214 Pfam match to entry PF01128.8 IspD 216596015215 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 216596015216 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 216596015217 FMN binding site [chemical binding]; other site 216596015218 active site 216596015219 catalytic residues [active] 216596015220 substrate binding site [chemical binding]; other site 216596015221 Pfam match to entry PF01207.7 Dus 216596015222 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 216596015223 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216596015224 dimer interface [polypeptide binding]; other site 216596015225 phosphorylation site [posttranslational modification] 216596015226 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596015227 ATP binding site [chemical binding]; other site 216596015228 Mg2+ binding site [ion binding]; other site 216596015229 G-X-G motif; other site 216596015230 Pfam match to entry PF00989.11 PAS 216596015231 Pfam match to entry PF00512.10 HisKA 216596015232 Pfam match to entry PF02518.9 HATPase_c 216596015233 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 216596015234 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596015235 active site 216596015236 phosphorylation site [posttranslational modification] 216596015237 intermolecular recognition site; other site 216596015238 dimerization interface [polypeptide binding]; other site 216596015239 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216596015240 Walker A motif; other site 216596015241 ATP binding site [chemical binding]; other site 216596015242 Walker B motif; other site 216596015243 arginine finger; other site 216596015244 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 216596015245 Pfam match to entry PF00072.9 Response_reg 216596015246 Pfam match to entry PF00158.12 Sigma54_activat 216596015247 Pfam match to entry PF02954.7 HTH_8 216596015248 1 probable transmembrane helix predicted at aa 7-29 216596015249 Predicted periplasmic protein (DUF2092); Region: DUF2092; pfam09865 216596015250 1 probable transmembrane helix predicted at aa 13-35 216596015251 Predicted integral membrane protein [Function unknown]; Region: COG5616 216596015252 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216596015253 TPR motif; other site 216596015254 binding surface 216596015255 TPR repeat; Region: TPR_11; pfam13414 216596015256 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216596015257 binding surface 216596015258 TPR motif; other site 216596015259 1 probable transmembrane helix predicted at aa 157-179 216596015260 4 probable transmembrane helices predicted at aa 24-46, 61-80, 92-114 and 118-140 216596015261 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 216596015262 Sulfatase; Region: Sulfatase; pfam00884 216596015263 Pfam match to entry PF00884.10 Sulfatase 216596015264 Uncharacterized conserved protein [Function unknown]; Region: COG1262 216596015265 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 216596015266 Pfam match to entry PF03781.4 DUF323 216596015267 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 216596015268 Sulfatase; Region: Sulfatase; pfam00884 216596015269 1 probable transmembrane helix predicted at aa 13-35 216596015270 Pfam match to entry PF00884.10 Sulfatase 216596015271 1 probable transmembrane helix predicted at aa 49-71 216596015272 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 216596015273 Ligand Binding Site [chemical binding]; other site 216596015274 Pfam match to entry PF00582.12 Usp 216596015275 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 216596015276 Pfam match to entry PF01988.8 DUF125 216596015277 5 probable transmembrane helices predicted at aa 21-43, 48-70, 146-168, 173-195 and 208-230 216596015278 Domain of unknown function DUF302; Region: DUF302; cl01364 216596015279 Pfam match to entry PF03625.3 DUF302 216596015280 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 216596015281 EF-hand domain pair; Region: EF_hand_5; pfam13499 216596015282 Ca2+ binding site [ion binding]; other site 216596015283 Pfam match to entry PF00036.14 efhand 216596015284 Pfam match to entry PF00036.14 efhand 216596015285 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 216596015286 ApbE family; Region: ApbE; pfam02424 216596015287 Pfam match to entry PF02424.5 ApbE 216596015288 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 216596015289 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 216596015290 Flavodoxin; Region: Flavodoxin_1; pfam00258 216596015291 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like2; cd06201 216596015292 FAD binding pocket [chemical binding]; other site 216596015293 FAD binding motif [chemical binding]; other site 216596015294 catalytic residues [active] 216596015295 NAD binding pocket [chemical binding]; other site 216596015296 phosphate binding motif [ion binding]; other site 216596015297 beta-alpha-beta structure motif; other site 216596015298 Pfam match to entry PF00175.8 NAD_binding_1 216596015299 Pfam match to entry PF00258.10 Flavodoxin_1 216596015300 3 probable transmembrane helices predicted at aa 7-29, 118-140 and 284-306 216596015301 Pfam match to entry PF03929.4 PepSY_TM 216596015302 Pfam match to entry PF03929.4 PepSY_TM 216596015303 Pfam match to entry PF03929.4 PepSY_TM 216596015304 Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029 216596015305 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 216596015306 1 probable transmembrane helix predicted at aa 111-133 216596015307 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 216596015308 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596015309 active site 216596015310 phosphorylation site [posttranslational modification] 216596015311 intermolecular recognition site; other site 216596015312 dimerization interface [polypeptide binding]; other site 216596015313 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216596015314 DNA binding site [nucleotide binding] 216596015315 Pfam match to entry PF00072.9 Response_reg 216596015316 Pfam match to entry PF00486.11 Trans_reg_C 216596015317 HAMP domain; Region: HAMP; pfam00672 216596015318 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 216596015319 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596015320 ATP binding site [chemical binding]; other site 216596015321 Mg2+ binding site [ion binding]; other site 216596015322 G-X-G motif; other site 216596015323 2 probable transmembrane helices predicted at aa 10-32 and 164-186 216596015324 Pfam match to entry PF00672.10 HAMP 216596015325 Pfam match to entry PF00512.10 HisKA 216596015326 Pfam match to entry PF02518.9 HATPase_c 216596015327 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 216596015328 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 216596015329 active site 216596015330 catalytic tetrad [active] 216596015331 Pfam match to entry PF00248.9 Aldo_ket_red 216596015332 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 216596015333 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 216596015334 dimerization interface [polypeptide binding]; other site 216596015335 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216596015336 dimer interface [polypeptide binding]; other site 216596015337 phosphorylation site [posttranslational modification] 216596015338 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596015339 ATP binding site [chemical binding]; other site 216596015340 Mg2+ binding site [ion binding]; other site 216596015341 G-X-G motif; other site 216596015342 4 probable transmembrane helices predicted at aa 23-45, 60-82, 103-125 and 299-321 216596015343 Pfam match to entry PF00672.10 HAMP 216596015344 Pfam match to entry PF00989.11 PAS 216596015345 Pfam match to entry PF00512.10 HisKA 216596015346 Pfam match to entry PF02518.9 HATPase_c 216596015347 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 216596015348 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596015349 active site 216596015350 phosphorylation site [posttranslational modification] 216596015351 intermolecular recognition site; other site 216596015352 dimerization interface [polypeptide binding]; other site 216596015353 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216596015354 Walker A motif; other site 216596015355 ATP binding site [chemical binding]; other site 216596015356 Walker B motif; other site 216596015357 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 216596015358 Pfam match to entry PF00072.9 Response_reg 216596015359 Pfam match to entry PF00158.12 Sigma54_activat 216596015360 Pfam match to entry PF02954.7 HTH_8 216596015361 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 216596015362 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 216596015363 homodimer interface [polypeptide binding]; other site 216596015364 substrate-cofactor binding pocket; other site 216596015365 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596015366 catalytic residue [active] 216596015367 Pfam match to entry PF01063.7 Aminotran_4 216596015368 bacterial Hfq-like; Region: Hfq; cd01716 216596015369 hexamer interface [polypeptide binding]; other site 216596015370 Sm1 motif; other site 216596015371 RNA binding site [nucleotide binding]; other site 216596015372 Sm2 motif; other site 216596015373 Pfam match to entry PF01423.9 LSM 216596015374 1 probable transmembrane helix predicted at aa 21-40 216596015375 GTPases [General function prediction only]; Region: HflX; COG2262 216596015376 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 216596015377 HflX GTPase family; Region: HflX; cd01878 216596015378 G1 box; other site 216596015379 GTP/Mg2+ binding site [chemical binding]; other site 216596015380 Switch I region; other site 216596015381 G2 box; other site 216596015382 G3 box; other site 216596015383 Switch II region; other site 216596015384 G4 box; other site 216596015385 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 216596015386 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 216596015387 homodimer interface [polypeptide binding]; other site 216596015388 metal binding site [ion binding]; metal-binding site 216596015389 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 216596015390 homodimer interface [polypeptide binding]; other site 216596015391 active site 216596015392 putative chemical substrate binding site [chemical binding]; other site 216596015393 metal binding site [ion binding]; metal-binding site 216596015394 Pfam match to entry PF03819.5 MazG 216596015395 Pfam match to entry PF03819.5 MazG 216596015396 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 216596015397 nucleoside/Zn binding site; other site 216596015398 dimer interface [polypeptide binding]; other site 216596015399 catalytic motif [active] 216596015400 Pfam match to entry PF00383.9 dCMP_cyt_deam 216596015401 siroheme synthase; Provisional; Region: cysG; PRK10637 216596015402 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 216596015403 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 216596015404 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 216596015405 active site 216596015406 SAM binding site [chemical binding]; other site 216596015407 homodimer interface [polypeptide binding]; other site 216596015408 Pfam match to entry PF00590.7 TP_methylase 216596015409 Protein of unknown function (DUF2849); Region: DUF2849; pfam11011 216596015410 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 216596015411 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 216596015412 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 216596015413 Pfam match to entry PF03460.3 NIR_SIR_ferr 216596015414 Pfam match to entry PF01077.8 NIR_SIR 216596015415 Pfam match to entry PF03460.3 NIR_SIR_ferr 216596015416 Pfam match to entry PF01077.8 NIR_SIR 216596015417 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3749 216596015418 Pfam match to entry PF06073.1 DUF934 216596015419 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494 216596015420 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 216596015421 1 probable transmembrane helix predicted at aa 7-26 216596015422 Pfam match to entry PF01360.9 Monooxygenase 216596015423 Predicted permeases [General function prediction only]; Region: COG0679 216596015424 10 probable transmembrane helices predicted at aa 4-21, 33-55, 65-87, 100-119,124-146, 167-189, 199-221, 228-250, 255-277 and 290-309 216596015425 Pfam match to entry PF03547.6 Auxin_eff 216596015426 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 216596015427 Pfam match to entry PF00753.12 Lactamase_B 216596015428 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 216596015429 classical (c) SDRs; Region: SDR_c; cd05233 216596015430 NAD(P) binding site [chemical binding]; other site 216596015431 active site 216596015432 Pfam match to entry PF00106.11 adh_short 216596015433 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 216596015434 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 216596015435 dimer interface [polypeptide binding]; other site 216596015436 NADP binding site [chemical binding]; other site 216596015437 catalytic residues [active] 216596015438 Pfam match to entry PF00171.9 Aldedh 216596015439 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 216596015440 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 216596015441 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 216596015442 FMN binding site [chemical binding]; other site 216596015443 substrate binding site [chemical binding]; other site 216596015444 putative catalytic residue [active] 216596015445 Pfam match to entry PF03060.4 NPD 216596015446 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 216596015447 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 216596015448 Pfam match to entry PF00296.10 Bac_luciferase 216596015449 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 216596015450 1 probable transmembrane helix predicted at aa 13-35 216596015451 Pfam match to entry PF00520.13 Ion_trans 216596015452 4 probable transmembrane helices predicted at aa 30-52, 94-116, 137-159 and 196-218 216596015453 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 216596015454 classical (c) SDRs; Region: SDR_c; cd05233 216596015455 NAD(P) binding site [chemical binding]; other site 216596015456 active site 216596015457 Pfam match to entry PF00106.11 adh_short 216596015458 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 216596015459 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 216596015460 6 probable transmembrane helices predicted at aa 15-37, 58-80, 95-117, 138-160,175-197 and 217-239 216596015461 Pfam match to entry PF02683.4 DsbD 216596015462 Domain of unknown function (DUF1476); Region: DUF1476; pfam07345 216596015463 Pfam match to entry PF07345.1 DUF1476 216596015464 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 216596015465 Pfam match to entry PF05532.1 CsbD 216596015466 1 probable transmembrane helix predicted at aa 12-34 216596015467 submitted without /pseudo; similarity:fasta; with=UniProt:Q92Y25_RHIME (EMBL:AE007292); Rhizobium meliloti (Sinorhizobium meliloti).; oxygenase.; length=511; id 64.741; 502 aa overlap; query 27-519; subject 1-498 216596015468 Pfam match to entry PF01360.9 Monooxygenase 216596015469 Protein of unknown function (DUF2956); Region: DUF2956; pfam11169 216596015470 Protein of unknown function (DUF982); Region: DUF982; pfam06169 216596015471 Pfam match to entry PF06169.1 DUF982 216596015472 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 216596015473 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 216596015474 cyclase homology domain; Region: CHD; cd07302 216596015475 nucleotidyl binding site; other site 216596015476 metal binding site [ion binding]; metal-binding site 216596015477 dimer interface [polypeptide binding]; other site 216596015478 Pfam match to entry PF00211.9 Guanylate_cyc 216596015479 Protein of unknown function (DUF982); Region: DUF982; pfam06169 216596015480 Pfam match to entry PF06169.1 DUF982 216596015481 hypothetical protein; Provisional; Region: PRK06184 216596015482 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 216596015483 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 216596015484 Pfam match to entry PF01360.9 Monooxygenase 216596015485 Pfam match to entry PF01494.7 FAD_binding_3 216596015486 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 216596015487 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216596015488 putative DNA binding site [nucleotide binding]; other site 216596015489 putative Zn2+ binding site [ion binding]; other site 216596015490 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 216596015491 Pfam match to entry PF01047.8 MarR 216596015492 Protein of unknown function (DUF2938); Region: DUF2938; pfam11158 216596015493 4 probable transmembrane helices predicted at aa 4-26, 66-88, 103-125 and 138-157 216596015494 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3828 216596015495 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 216596015496 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 216596015497 Pfam match to entry PF01408.8 GFO_IDH_MocA 216596015498 1 probable transmembrane helix predicted at aa 12-34 216596015499 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 216596015500 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 216596015501 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 216596015502 Pfam match to entry PF00480.8 ROK 216596015503 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 216596015504 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 216596015505 1 probable transmembrane helix predicted at aa 20-42 216596015506 Pfam match to entry PF01547.11 SBP_bac_1 216596015507 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596015508 dimer interface [polypeptide binding]; other site 216596015509 conserved gate region; other site 216596015510 putative PBP binding loops; other site 216596015511 ABC-ATPase subunit interface; other site 216596015512 6 probable transmembrane helices predicted at aa 31-53, 95-117, 124-146, 177-199,229-251 and 282-304 216596015513 Pfam match to entry PF00528.10 BPD_transp_1 216596015514 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216596015515 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596015516 dimer interface [polypeptide binding]; other site 216596015517 conserved gate region; other site 216596015518 putative PBP binding loops; other site 216596015519 ABC-ATPase subunit interface; other site 216596015520 6 probable transmembrane helices predicted at aa 13-35, 79-101, 108-130, 140-160,198-220 and 240-262 216596015521 Pfam match to entry PF00528.10 BPD_transp_1 216596015522 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 216596015523 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 216596015524 Walker A/P-loop; other site 216596015525 ATP binding site [chemical binding]; other site 216596015526 Q-loop/lid; other site 216596015527 ABC transporter signature motif; other site 216596015528 Walker B; other site 216596015529 D-loop; other site 216596015530 H-loop/switch region; other site 216596015531 TOBE domain; Region: TOBE_2; pfam08402 216596015532 Pfam match to entry PF00005.11 ABC_tran 216596015533 Pfam match to entry PF03459.4 TOBE 216596015534 Pfam match to entry PF03459.4 TOBE 216596015535 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 216596015536 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 216596015537 Pfam match to entry PF03050.4 Transposase_25 216596015538 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216596015539 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 216596015540 Uncharacterized conserved protein [Function unknown]; Region: COG3791 216596015541 Pfam match to entry PF04828.3 DUF636 216596015542 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216596015543 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 216596015544 Cupin; Region: Cupin_6; pfam12852 216596015545 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216596015546 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216596015547 Pfam match to entry PF00165.8 HTH_AraC 216596015548 Pfam match to entry PF00165.8 HTH_AraC 216596015549 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 216596015550 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 216596015551 putative active site [active] 216596015552 catalytic residue [active] 216596015553 Pfam match to entry PF00701.10 DHDPS 216596015554 D-mannonate dehydratase [Carbohydrate transport and metabolism]; Region: UxuA; COG1312 216596015555 mannonate dehydratase; Region: uxuA; TIGR00695 216596015556 Pfam match to entry PF03786.3 UxuA 216596015557 Transcriptional regulators [Transcription]; Region: FadR; COG2186 216596015558 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596015559 DNA-binding site [nucleotide binding]; DNA binding site 216596015560 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 216596015561 Pfam match to entry PF00392.9 GntR 216596015562 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 216596015563 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 216596015564 Pfam match to entry PF00496.8 SBP_bac_5 216596015565 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 216596015566 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596015567 dimer interface [polypeptide binding]; other site 216596015568 conserved gate region; other site 216596015569 putative PBP binding loops; other site 216596015570 ABC-ATPase subunit interface; other site 216596015571 6 probable transmembrane helices predicted at aa 13-35, 105-127, 139-161, 199-221,265-287 and 307-326 216596015572 Pfam match to entry PF00528.10 BPD_transp_1 216596015573 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 216596015574 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 216596015575 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596015576 dimer interface [polypeptide binding]; other site 216596015577 conserved gate region; other site 216596015578 putative PBP binding loops; other site 216596015579 ABC-ATPase subunit interface; other site 216596015580 6 probable transmembrane helices predicted at aa 36-58, 103-125, 146-168, 193-215,222-244 and 264-286 216596015581 Pfam match to entry PF00528.10 BPD_transp_1 216596015582 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 216596015583 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596015584 Walker A/P-loop; other site 216596015585 ATP binding site [chemical binding]; other site 216596015586 Q-loop/lid; other site 216596015587 ABC transporter signature motif; other site 216596015588 Walker B; other site 216596015589 D-loop; other site 216596015590 H-loop/switch region; other site 216596015591 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216596015592 Pfam match to entry PF00005.11 ABC_tran 216596015593 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 216596015594 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596015595 Walker A/P-loop; other site 216596015596 ATP binding site [chemical binding]; other site 216596015597 Q-loop/lid; other site 216596015598 ABC transporter signature motif; other site 216596015599 Walker B; other site 216596015600 D-loop; other site 216596015601 H-loop/switch region; other site 216596015602 Pfam match to entry PF00005.11 ABC_tran 216596015603 Transcriptional regulators [Transcription]; Region: PurR; COG1609 216596015604 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216596015605 DNA binding site [nucleotide binding] 216596015606 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 216596015607 ligand binding site [chemical binding]; other site 216596015608 dimerization interface [polypeptide binding]; other site 216596015609 Pfam match to entry PF00532.8 Peripla_BP_1 216596015610 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 216596015611 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 216596015612 Pfam match to entry PF01547.11 SBP_bac_1 216596015613 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596015614 dimer interface [polypeptide binding]; other site 216596015615 ABC-ATPase subunit interface; other site 216596015616 putative PBP binding loops; other site 216596015617 6 probable transmembrane helices predicted at aa 50-72, 121-143, 155-177, 205-227,248-270 and 312-334 216596015618 Pfam match to entry PF00528.10 BPD_transp_1 216596015619 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216596015620 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596015621 dimer interface [polypeptide binding]; other site 216596015622 conserved gate region; other site 216596015623 putative PBP binding loops; other site 216596015624 ABC-ATPase subunit interface; other site 216596015625 6 probable transmembrane helices predicted at aa 21-43, 150-169, 182-204, 214-236,257-279 and 312-334 216596015626 Pfam match to entry PF00528.10 BPD_transp_1 216596015627 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 216596015628 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 216596015629 Walker A/P-loop; other site 216596015630 ATP binding site [chemical binding]; other site 216596015631 Q-loop/lid; other site 216596015632 ABC transporter signature motif; other site 216596015633 Walker B; other site 216596015634 D-loop; other site 216596015635 H-loop/switch region; other site 216596015636 TOBE domain; Region: TOBE_2; pfam08402 216596015637 Pfam match to entry PF00005.11 ABC_tran 216596015638 Pfam match to entry PF03459.4 TOBE 216596015639 submitted without /pseudo; similarity:fasta; with=UniProt:Q8P4J8_XANCP (EMBL:AE012491); Xanthomonas campestris (pv. campestris).; yagR; OrderedLocusNames=XCC3709; Oxidoreductase. Oxidoreductase.; length=737; id 73.333; 735 aa overlap; query 1-735; subject 1-735 216596015640 Pfam match to entry PF02738.5 Ald_Xan_dh_C2 216596015641 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 216596015642 Pfam match to entry PF04909.2 Amidohydro_2 216596015643 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 216596015644 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 216596015645 potential catalytic triad [active] 216596015646 conserved cys residue [active] 216596015647 Pfam match to entry PF01965.9 DJ-1_PfpI 216596015648 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596015649 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596015650 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 216596015651 putative effector binding pocket; other site 216596015652 putative dimerization interface [polypeptide binding]; other site 216596015653 Pfam match to entry PF00126.10 HTH_1 216596015654 Pfam match to entry PF03466.5 LysR_substrate 216596015655 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596015656 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596015657 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 216596015658 putative effector binding pocket; other site 216596015659 putative dimerization interface [polypeptide binding]; other site 216596015660 Pfam match to entry PF03466.5 LysR_substrate 216596015661 Pfam match to entry PF00126.10 HTH_1 216596015662 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 216596015663 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 216596015664 Pfam match to entry PF02627.6 CMD 216596015665 Pfam match to entry PF02627.6 CMD 216596015666 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 216596015667 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 216596015668 active site 216596015669 catalytic tetrad [active] 216596015670 Pfam match to entry PF00248.9 Aldo_ket_red 216596015671 Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; pfam10012 216596015672 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 216596015673 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216596015674 NAD(P) binding site [chemical binding]; other site 216596015675 active site 216596015676 Pfam match to entry PF00106.11 adh_short 216596015677 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 216596015678 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 216596015679 putative NAD(P) binding site [chemical binding]; other site 216596015680 Pfam match to entry PF00107.10 ADH_zinc_N 216596015681 Predicted transcriptional regulator [Transcription]; Region: COG2378 216596015682 HTH domain; Region: HTH_11; pfam08279 216596015683 WYL domain; Region: WYL; pfam13280 216596015684 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 216596015685 3 probable transmembrane helices predicted at aa 17-34, 49-71 and 92-114 216596015686 Uncharacterized conserved protein [Function unknown]; Region: COG3791 216596015687 Pfam match to entry PF04828.3 DUF636 216596015688 macrolide transporter subunit MacA; Provisional; Region: PRK11578 216596015689 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 216596015690 HlyD family secretion protein; Region: HlyD_3; pfam13437 216596015691 1 probable transmembrane helix predicted at aa 40-59 216596015692 Pfam match to entry PF00529.8 HlyD 216596015693 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 216596015694 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 216596015695 Walker A/P-loop; other site 216596015696 ATP binding site [chemical binding]; other site 216596015697 Q-loop/lid; other site 216596015698 ABC transporter signature motif; other site 216596015699 Walker B; other site 216596015700 D-loop; other site 216596015701 H-loop/switch region; other site 216596015702 Pfam match to entry PF00005.11 ABC_tran 216596015703 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 216596015704 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 216596015705 FtsX-like permease family; Region: FtsX; pfam02687 216596015706 4 probable transmembrane helices predicted at aa 21-43, 277-299, 329-351 and 361-383 216596015707 Pfam match to entry PF02687.7 FtsX 216596015708 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216596015709 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 216596015710 active site 216596015711 Pfam match to entry PF00903.11 Glyoxalase 216596015712 Transcriptional regulators [Transcription]; Region: GntR; COG1802 216596015713 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596015714 DNA-binding site [nucleotide binding]; DNA binding site 216596015715 FCD domain; Region: FCD; pfam07729 216596015716 Pfam match to entry PF00392.9 GntR 216596015717 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 216596015718 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 216596015719 FAD binding pocket [chemical binding]; other site 216596015720 FAD binding motif [chemical binding]; other site 216596015721 phosphate binding motif [ion binding]; other site 216596015722 beta-alpha-beta structure motif; other site 216596015723 NAD binding pocket [chemical binding]; other site 216596015724 Pfam match to entry PF00970.9 FAD_binding_6 216596015725 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 216596015726 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 216596015727 6 probable transmembrane helices predicted at aa 16-38, 102-124, 133-152, 156-178,190-208 and 213-235 216596015728 Pfam match to entry PF01066.9 CDP-OH_P_transf 216596015729 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 216596015730 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 216596015731 NADP binding site [chemical binding]; other site 216596015732 dimer interface [polypeptide binding]; other site 216596015733 Pfam match to entry PF00107.10 ADH_zinc_N 216596015734 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 216596015735 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 216596015736 Walker A/P-loop; other site 216596015737 ATP binding site [chemical binding]; other site 216596015738 Q-loop/lid; other site 216596015739 ABC transporter signature motif; other site 216596015740 Walker B; other site 216596015741 D-loop; other site 216596015742 H-loop/switch region; other site 216596015743 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 216596015744 Pfam match to entry PF00005.11 ABC_tran 216596015745 Pfam match to entry PF00005.11 ABC_tran 216596015746 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596015747 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 216596015748 TM-ABC transporter signature motif; other site 216596015749 10 probable transmembrane helices predicted at aa 16-38, 58-80, 87-109, 119-138,147-169, 199-221, 247-266, 270-292, 297-319 and 329-351 216596015750 Pfam match to entry PF02653.5 BPD_transp_2 216596015751 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596015752 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 216596015753 TM-ABC transporter signature motif; other site 216596015754 9 probable transmembrane helices predicted at aa 4-26, 33-55, 60-82, 89-111,141-158, 188-207, 217-234, 241-263 and 267-284 216596015755 Pfam match to entry PF02653.5 BPD_transp_2 216596015756 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 216596015757 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 216596015758 putative ligand binding site [chemical binding]; other site 216596015759 Pfam match to entry PF02608.4 Bmp 216596015760 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 216596015761 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 216596015762 putative ligand binding site [chemical binding]; other site 216596015763 Pfam match to entry PF00532.8 Peripla_BP_1 216596015764 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 216596015765 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 216596015766 Walker A/P-loop; other site 216596015767 ATP binding site [chemical binding]; other site 216596015768 Q-loop/lid; other site 216596015769 ABC transporter signature motif; other site 216596015770 Walker B; other site 216596015771 D-loop; other site 216596015772 H-loop/switch region; other site 216596015773 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 216596015774 Pfam match to entry PF00005.11 ABC_tran 216596015775 Pfam match to entry PF00005.11 ABC_tran 216596015776 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596015777 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216596015778 TM-ABC transporter signature motif; other site 216596015779 10 probable transmembrane helices predicted at aa 7-29, 49-68, 75-94, 99-121,128-150, 165-187, 214-236, 246-268, 273-295 and 305-327 216596015780 Pfam match to entry PF02653.5 BPD_transp_2 216596015781 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596015782 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216596015783 TM-ABC transporter signature motif; other site 216596015784 8 probable transmembrane helices predicted at aa 5-27, 47-80, 87-109, 114-136,157-179, 210-232, 253-275 and 295-317 216596015785 Pfam match to entry PF02653.5 BPD_transp_2 216596015786 Transcriptional regulators [Transcription]; Region: FadR; COG2186 216596015787 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596015788 DNA-binding site [nucleotide binding]; DNA binding site 216596015789 FCD domain; Region: FCD; pfam07729 216596015790 Pfam match to entry PF00392.9 GntR 216596015791 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 216596015792 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 216596015793 Substrate binding site; other site 216596015794 Mg++ binding site; other site 216596015795 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 216596015796 active site 216596015797 substrate binding site [chemical binding]; other site 216596015798 CoA binding site [chemical binding]; other site 216596015799 Pfam match to entry PF00483.9 NTP_transferase 216596015800 Pfam match to entry PF00132.9 Hexapep 216596015801 Pfam match to entry PF00132.9 Hexapep 216596015802 Pfam match to entry PF00132.9 Hexapep 216596015803 Pfam match to entry PF00132.9 Hexapep 216596015804 Pfam match to entry PF00132.9 Hexapep 216596015805 Pfam match to entry PF00132.9 Hexapep 216596015806 1 probable transmembrane helix predicted at aa 5-27 216596015807 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 216596015808 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 216596015809 glutaminase active site [active] 216596015810 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 216596015811 dimer interface [polypeptide binding]; other site 216596015812 active site 216596015813 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 216596015814 dimer interface [polypeptide binding]; other site 216596015815 active site 216596015816 Pfam match to entry PF00310.9 GATase_2 216596015817 Pfam match to entry PF01380.9 SIS 216596015818 Pfam match to entry PF01380.9 SIS 216596015819 Uncharacterized conserved protein [Function unknown]; Region: COG2928 216596015820 4 probable transmembrane helices predicted at aa 19-41, 61-83, 131-150 and 165-184 216596015821 Pfam match to entry PF04367.2 DUF502 216596015822 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 216596015823 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 216596015824 generic binding surface II; other site 216596015825 ssDNA binding site; other site 216596015826 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 216596015827 ATP binding site [chemical binding]; other site 216596015828 putative Mg++ binding site [ion binding]; other site 216596015829 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216596015830 nucleotide binding region [chemical binding]; other site 216596015831 ATP-binding site [chemical binding]; other site 216596015832 Pfam match to entry PF00271.13 Helicase_C 216596015833 Pfam match to entry PF00270.12 DEAD 216596015834 Uncharacterized conserved protein [Function unknown]; Region: COG2938 216596015835 Pfam match to entry PF03937.3 TPR_div1 216596015836 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 216596015837 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 216596015838 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 216596015839 ATP binding site [chemical binding]; other site 216596015840 putative Mg++ binding site [ion binding]; other site 216596015841 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216596015842 nucleotide binding region [chemical binding]; other site 216596015843 ATP-binding site [chemical binding]; other site 216596015844 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 216596015845 Pfam match to entry PF02559.4 CarD_TRCF 216596015846 Pfam match to entry PF00270.12 DEAD 216596015847 Pfam match to entry PF00271.13 Helicase_C 216596015848 Pfam match to entry PF03461.4 TRCF 216596015849 OsmC-like protein; Region: OsmC; cl00767 216596015850 Pfam match to entry PF02566.5 OsmC 216596015851 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 216596015852 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 216596015853 catalytic residues [active] 216596015854 Pfam match to entry PF01323.9 DSBA 216596015855 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 216596015856 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 216596015857 Pfam match to entry PF00496.8 SBP_bac_5 216596015858 Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342 216596015859 Pfam match to entry PF06776.1 IalB 216596015860 Uncharacterized conserved protein [Function unknown]; Region: COG3785 216596015861 glutamine synthetase; Provisional; Region: glnA; PRK09469 216596015862 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 216596015863 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 216596015864 Pfam match to entry PF00120.9 Gln-synt_C 216596015865 Pfam match to entry PF03951.4 Gln-synt_N 216596015866 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 216596015867 Nitrogen regulatory protein P-II; Region: P-II; smart00938 216596015868 Pfam match to entry PF00543.8 P-II 216596015869 putative carbohydrate kinase; Provisional; Region: PRK10565 216596015870 Uncharacterized conserved protein [Function unknown]; Region: COG0062 216596015871 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 216596015872 putative substrate binding site [chemical binding]; other site 216596015873 putative ATP binding site [chemical binding]; other site 216596015874 Pfam match to entry PF03853.3 YjeF_N 216596015875 Pfam match to entry PF01256.7 Carb_kinase 216596015876 Protein of unknown function (DUF808); Region: DUF808; cl01002 216596015877 Pfam match to entry PF05661.2 DUF808 216596015878 4 probable transmembrane helices predicted at aa 189-211, 288-310, 345-367 and 406-428 216596015879 Protein of unknown function DUF72; Region: DUF72; pfam01904 216596015880 Pfam match to entry PF01904.6 DUF72 216596015881 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 216596015882 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216596015883 Coenzyme A binding pocket [chemical binding]; other site 216596015884 Pfam match to entry PF00583.9 Acetyltransf_1 216596015885 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 216596015886 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 216596015887 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 216596015888 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 216596015889 Pfam match to entry PF00005.11 ABC_tran 216596015890 Pfam match to entry PF00005.11 ABC_tran 216596015891 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 216596015892 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 216596015893 dimer interface [polypeptide binding]; other site 216596015894 ssDNA binding site [nucleotide binding]; other site 216596015895 tetramer (dimer of dimers) interface [polypeptide binding]; other site 216596015896 Pfam match to entry PF00436.11 SSB 216596015897 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 216596015898 Pfam match to entry PF01914.6 MarC 216596015899 6 probable transmembrane helices predicted at aa 10-32, 44-66, 70-92, 117-139,149-168 and 181-200 216596015900 DNA gyrase subunit A; Validated; Region: PRK05560 216596015901 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 216596015902 CAP-like domain; other site 216596015903 active site 216596015904 primary dimer interface [polypeptide binding]; other site 216596015905 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 216596015906 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 216596015907 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 216596015908 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 216596015909 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 216596015910 Pfam match to entry PF00521.7 DNA_topoisoIV 216596015911 Pfam match to entry PF03989.2 DNA_gyraseA_C 216596015912 Pfam match to entry PF03989.2 DNA_gyraseA_C 216596015913 Pfam match to entry PF03989.2 DNA_gyraseA_C 216596015914 Pfam match to entry PF03989.2 DNA_gyraseA_C 216596015915 Pfam match to entry PF03989.2 DNA_gyraseA_C 216596015916 Pfam match to entry PF03989.2 DNA_gyraseA_C 216596015917 1 probable transmembrane helix predicted at aa 137-159 216596015918 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 216596015919 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 216596015920 active site 216596015921 (T/H)XGH motif; other site 216596015922 Pfam match to entry PF01467.12 CTP_transf_2 216596015923 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 216596015924 active site 216596015925 Pfam match to entry PF00160.9 Pro_isomerase 216596015926 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 216596015927 active site 216596015928 Pfam match to entry PF00160.9 Pro_isomerase 216596015929 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 216596015930 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 216596015931 Pfam match to entry PF02547.5 Queuosine_synth 216596015932 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 216596015933 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 216596015934 Pfam match to entry PF01702.6 TGT 216596015935 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 216596015936 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 216596015937 dimer interface [polypeptide binding]; other site 216596015938 active site 216596015939 Pfam match to entry PF02801.7 Ketoacyl-synt_C 216596015940 Pfam match to entry PF00109.11 ketoacyl-synt 216596015941 Predicted transcriptional regulators [Transcription]; Region: COG1733 216596015942 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 216596015943 Pfam match to entry PF01638.6 DUF24 216596015944 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Validated; Region: PRK05778 216596015945 3 probable transmembrane helices predicted at aa 7-29, 49-71 and 78-95 216596015946 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 216596015947 Pfam match to entry PF00353.8 HemolysinCabind 216596015948 Pfam match to entry PF00353.8 HemolysinCabind 216596015949 Pfam match to entry PF00353.8 HemolysinCabind 216596015950 Pfam match to entry PF00353.8 HemolysinCabind 216596015951 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 216596015952 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 216596015953 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 216596015954 catalytic site [active] 216596015955 active site 216596015956 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 216596015957 Pfam match to entry PF02922.6 Isoamylase_N 216596015958 Pfam match to entry PF00128.11 Alpha-amylase 216596015959 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 216596015960 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 216596015961 active site 216596015962 metal binding site [ion binding]; metal-binding site 216596015963 Pfam match to entry PF00149.12 Metallophos 216596015964 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 216596015965 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216596015966 Walker A/P-loop; other site 216596015967 ATP binding site [chemical binding]; other site 216596015968 Q-loop/lid; other site 216596015969 ABC transporter signature motif; other site 216596015970 Walker B; other site 216596015971 D-loop; other site 216596015972 H-loop/switch region; other site 216596015973 TOBE domain; Region: TOBE_2; pfam08402 216596015974 Pfam match to entry PF00005.11 ABC_tran 216596015975 Pfam match to entry PF03459.4 TOBE 216596015976 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 216596015977 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596015978 putative PBP binding loops; other site 216596015979 ABC-ATPase subunit interface; other site 216596015980 6 probable transmembrane helices predicted at aa 28-50, 86-108, 120-142, 175-197,217-239 and 273-295 216596015981 Pfam match to entry PF00528.10 BPD_transp_1 216596015982 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216596015983 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596015984 dimer interface [polypeptide binding]; other site 216596015985 conserved gate region; other site 216596015986 putative PBP binding loops; other site 216596015987 ABC-ATPase subunit interface; other site 216596015988 6 probable transmembrane helices predicted at aa 12-34, 73-95, 108-130, 140-162,183-205 and 242-264 216596015989 Pfam match to entry PF00528.10 BPD_transp_1 216596015990 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 216596015991 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 216596015992 1 probable transmembrane helix predicted at aa 7-29 216596015993 Pfam match to entry PF01547.11 SBP_bac_1 216596015994 Transcriptional regulators [Transcription]; Region: PurR; COG1609 216596015995 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216596015996 DNA binding site [nucleotide binding] 216596015997 Ligand-binding domain of putative DNA transcription repressors highly similar to that of the repressor specific for gluconate (GntR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_2; cd06282 216596015998 putative dimerization interface [polypeptide binding]; other site 216596015999 putative ligand binding site [chemical binding]; other site 216596016000 Pfam match to entry PF00532.8 Peripla_BP_1 216596016001 Pfam match to entry PF00356.8 LacI 216596016002 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 216596016003 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 216596016004 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 216596016005 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 216596016006 Pfam match to entry PF00675.9 Peptidase_M16 216596016007 Pfam match to entry PF05193.5 Peptidase_M16_C 216596016008 Pfam match to entry PF05193.5 Peptidase_M16_C 216596016009 Predicted acetyltransferase [General function prediction only]; Region: COG3393 216596016010 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216596016011 Coenzyme A binding pocket [chemical binding]; other site 216596016012 Pfam match to entry PF00583.9 Acetyltransf_1 216596016013 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216596016014 putative Zn2+ binding site [ion binding]; other site 216596016015 putative DNA binding site [nucleotide binding]; other site 216596016016 Pfam match to entry PF01047.8 MarR 216596016017 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216596016018 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596016019 putative substrate translocation pore; other site 216596016020 12 probable transmembrane helices predicted at aa 27-49, 64-86, 93-115, 125-147,156-178, 182-204, 217-239, 261-280, 293-315, 319-338,345-364 and 374-396 216596016021 agmatinase; Region: agmatinase; TIGR01230 216596016022 Agmatinase and related proteins; Region: Agmatinase_like_1; cd11589 216596016023 oligomer interface [polypeptide binding]; other site 216596016024 active site 216596016025 Mn binding site [ion binding]; other site 216596016026 Pfam match to entry PF00491.9 Arginase 216596016027 membrane protein; Provisional; Region: PRK14407 216596016028 Pfam match to entry PF02660.4 DUF205 216596016029 5 probable transmembrane helices predicted at aa 4-26, 57-79, 99-121, 133-155 and 160-179 216596016030 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216596016031 DNA binding site [nucleotide binding] 216596016032 Predicted integral membrane protein [Function unknown]; Region: COG5616 216596016033 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216596016034 TPR motif; other site 216596016035 binding surface 216596016036 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216596016037 TPR motif; other site 216596016038 binding surface 216596016039 Pfam match to entry PF00486.11 Trans_reg_C 216596016040 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 216596016041 Pfam match to entry PF06078.1 DUF937 216596016042 1 probable transmembrane helix predicted at aa 25-47 216596016043 Predicted metal-binding protein [General function prediction only]; Region: COG3019 216596016044 Pfam match to entry PF04214.2 DUF411 216596016045 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363 216596016046 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 216596016047 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 216596016048 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 216596016049 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 216596016050 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 216596016051 1 probable transmembrane helix predicted at aa 19-41 216596016052 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 216596016053 Pfam match to entry PF01292.9 Ni_hydr_CYTB 216596016054 2 probable transmembrane helices predicted at aa 101-123 and 128-150 216596016055 cytochrome c-like protein, pseudogene; Similar to codons 63 to the C-terminus of Rhizobium meliloti (Sinorhizobium meliloti) cytochrome c-like protein. UniProt:Q92ZD5_RHIME (EMBL:AE007246) (206 aa); similarity:fasta; with=UniProt:Q92ZD5_RHIME (EMBL:AE007246); Rhizobium meliloti (Sinorhizobium meliloti).; cytochrome C-like protein.; length=206; id 52.482; 141 aa overlap; query 1-141; subject 63-203 216596016056 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 216596016057 putative catalytic residues [active] 216596016058 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 216596016059 Double zinc ribbon; Region: DZR; pfam12773 216596016060 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 216596016061 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 216596016062 cyclase homology domain; Region: CHD; cd07302 216596016063 nucleotidyl binding site; other site 216596016064 metal binding site [ion binding]; metal-binding site 216596016065 dimer interface [polypeptide binding]; other site 216596016066 Predicted ATPase [General function prediction only]; Region: COG3899 216596016067 AAA ATPase domain; Region: AAA_16; pfam13191 216596016068 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216596016069 Tetratricopeptide repeat; Region: TPR_12; pfam13424 216596016070 TPR motif; other site 216596016071 Pfam match to entry PF00515.11 TPR 216596016072 Pfam match to entry PF00515.11 TPR 216596016073 Pfam match to entry PF00515.11 TPR 216596016074 Pfam match to entry PF00515.11 TPR 216596016075 Pfam match to entry PF00211.9 Guanylate_cyc 216596016076 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 216596016077 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 216596016078 PYR/PP interface [polypeptide binding]; other site 216596016079 dimer interface [polypeptide binding]; other site 216596016080 TPP binding site [chemical binding]; other site 216596016081 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 216596016082 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 216596016083 TPP-binding site [chemical binding]; other site 216596016084 dimer interface [polypeptide binding]; other site 216596016085 Pfam match to entry PF00205.10 TPP_enzyme_M 216596016086 Pfam match to entry PF02776.6 TPP_enzyme_N 216596016087 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596016088 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596016089 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 216596016090 dimerization interface [polypeptide binding]; other site 216596016091 Pfam match to entry PF03466.5 LysR_substrate 216596016092 Pfam match to entry PF00126.10 HTH_1 216596016093 hypothetical protein; Provisional; Region: PRK05463 216596016094 Pfam match to entry PF07286.1 DUF1445 216596016095 benzoate transport; Region: 2A0115; TIGR00895 216596016096 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596016097 putative substrate translocation pore; other site 216596016098 Pfam match to entry PF00083.9 Sugar_tr 216596016099 12 probable transmembrane helices predicted at aa 31-53, 63-85, 97-119, 123-145,158-177, 182-204, 239-261, 271-293, 305-324, 328-350,370-389 and 394-413 216596016100 5-oxoprolinase; Region: PLN02666 216596016101 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 216596016102 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 216596016103 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 216596016104 Pfam match to entry PF05378.1 Hydant_A_N 216596016105 Pfam match to entry PF01968.6 Hydantoinase_A 216596016106 Pfam match to entry PF02538.4 Hydantoinase_B 216596016107 Transcriptional regulators [Transcription]; Region: PurR; COG1609 216596016108 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216596016109 DNA binding site [nucleotide binding] 216596016110 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 216596016111 putative dimerization interface [polypeptide binding]; other site 216596016112 putative ligand binding site [chemical binding]; other site 216596016113 Pfam match to entry PF00532.8 Peripla_BP_1 216596016114 Periplasmic sugar-binding domain of Thermotoga maritima glucose-binding protein (tmGBP) and its close homologs; Region: PBP1_tmGBP; cd06314 216596016115 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 216596016116 ligand binding site [chemical binding]; other site 216596016117 dimerization interface [polypeptide binding]; other site 216596016118 1 probable transmembrane helix predicted at aa 7-29 216596016119 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 216596016120 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216596016121 Walker A/P-loop; other site 216596016122 ATP binding site [chemical binding]; other site 216596016123 Q-loop/lid; other site 216596016124 ABC transporter signature motif; other site 216596016125 Walker B; other site 216596016126 D-loop; other site 216596016127 H-loop/switch region; other site 216596016128 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 216596016129 Pfam match to entry PF00005.11 ABC_tran 216596016130 Pfam match to entry PF00005.11 ABC_tran 216596016131 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596016132 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216596016133 TM-ABC transporter signature motif; other site 216596016134 8 probable transmembrane helices predicted at aa 7-29, 39-58, 60-79, 84-106,111-133, 153-175, 207-229 and 282-304 216596016135 Pfam match to entry PF02653.5 BPD_transp_2 216596016136 conserved hypothetical protein, pseudogene; Similar to N-terminus to codon 155 of Agrobacterium tumefaciens hypothetical protein. UniProt:Q9ADZ4_9RHIZ (EMBL:AF065242) (464 aa); similarity:fasta; with=UniProt:Q9ADZ4_9RHIZ (EMBL:AF065242); Agrobacterium tumefaciens.; Hypothetical protein.; length=464; id 87.333; 150 aa overlap; query 1-150; subject 5-154 216596016137 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 216596016138 Helix-turn-helix domain; Region: HTH_38; pfam13936 216596016139 DNA-binding interface [nucleotide binding]; DNA binding site 216596016140 Integrase core domain; Region: rve; pfam00665 216596016141 Pfam match to entry PF00665.10 rve 216596016142 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 216596016143 Mechanosensitive ion channel; Region: MS_channel; pfam00924 216596016144 Pfam match to entry PF00924.8 MS_channel 216596016145 11 probable transmembrane helices predicted at aa 13-35, 126-148, 174-196, 206-228,249-268, 283-305, 312-334, 338-355, 423-445, 474-496 and 503-525 216596016146 Epoxide hydrolase N terminus; Region: EHN; pfam06441 216596016147 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 216596016148 Pfam match to entry PF06441.1 EHN 216596016149 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216596016150 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 216596016151 Pfam match to entry PF00903.11 Glyoxalase 216596016152 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 216596016153 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 216596016154 Pfam match to entry PF00561.8 Abhydrolase_1 216596016155 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596016156 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596016157 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216596016158 dimerization interface [polypeptide binding]; other site 216596016159 Pfam match to entry PF03466.5 LysR_substrate 216596016160 Pfam match to entry PF00126.10 HTH_1 216596016161 Protein of unknown function, DUF599; Region: DUF599; pfam04654 216596016162 Pfam match to entry PF04654.2 DUF599 216596016163 4 probable transmembrane helices predicted at aa 4-26, 65-87, 107-126 and 186-208 216596016164 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 216596016165 Pfam match to entry PF02626.5 AHS2 216596016166 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 216596016167 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 216596016168 Pfam match to entry PF02682.5 AHS1 216596016169 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 216596016170 putative active site [active] 216596016171 Pfam match to entry PF03746.4 LamB_YcsF 216596016172 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216596016173 PAS fold; Region: PAS_3; pfam08447 216596016174 putative active site [active] 216596016175 heme pocket [chemical binding]; other site 216596016176 similarity:fasta; with=UniProt:Q8KKU4_RHIET (EMBL:U80928); Rhizobium etli.; yp088; Hypothetical protein yp088.; length=273; id 45.353; 269 aa overlap; query 1-219; subject 5-273; conserved hypothetical protein, pseudogene 216596016177 Predicted membrane protein [Function unknown]; Region: COG3174 216596016178 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 216596016179 14 probable transmembrane helices predicted at aa 10-29, 41-63, 67-84, 96-115,119-141, 146-168, 183-200, 207-229, 244-266, 273-295,310-332, 339-361, 371-390, 397-419 216596016180 conserved hypothetical protein, pseudogene; N-terminus to coodn 160 is similar to codons 45 to the C-terminus of Rhizobium loti (Mesorhizobium loti) mll2445 protein. UniProt:Q98ID9_RHILO (EMBL:BA000012) (200 aa); similarity:fasta; with=UniProt:Q98ID9_RHILO (EMBL:BA000012); Rhizobium loti (Mesorhizobium loti).; Mll2445 protein.; length=200; id 27.632; 152 aa overlap; query 6-156; subject 44-188 216596016181 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 216596016182 Pfam match to entry PF03741.3 TerC 216596016183 4 probable transmembrane helices predicted at aa 15-37, 58-80, 144-166 and 173-195 216596016184 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 216596016185 putative hydrolase; Provisional; Region: PRK02113 216596016186 Pfam match to entry PF00753.12 Lactamase_B 216596016187 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 216596016188 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 216596016189 active site 216596016190 Pfam match to entry PF01026.9 TatD_DNase 216596016191 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 216596016192 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 216596016193 active site 216596016194 HIGH motif; other site 216596016195 KMSKS motif; other site 216596016196 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 216596016197 tRNA binding surface [nucleotide binding]; other site 216596016198 anticodon binding site; other site 216596016199 Pfam match to entry PF00133.8 tRNA-synt_1 216596016200 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 216596016201 Pfam match to entry PF01925.8 DUF81 216596016202 8 probable transmembrane helices predicted at aa 46-68, 73-95, 113-135, 140-162,186-220, 233-250, 255-277 and 284-301 216596016203 DNA polymerase III subunit delta'; Validated; Region: PRK09112 216596016204 AAA ATPase domain; Region: AAA_16; pfam13191 216596016205 DNA polymerase III subunit delta'; Validated; Region: PRK08485 216596016206 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 216596016207 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 216596016208 TMP-binding site; other site 216596016209 ATP-binding site [chemical binding]; other site 216596016210 Pfam match to entry PF02223.5 Thymidylate_kin 216596016211 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 216596016212 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 216596016213 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 216596016214 Pfam match to entry PF00768.8 Peptidase_S11 216596016215 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 216596016216 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 216596016217 Pfam match to entry PF03330.5 DPBB_1 216596016218 GYD domain; Region: GYD; pfam08734 216596016219 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 216596016220 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216596016221 metal binding site [ion binding]; metal-binding site 216596016222 active site 216596016223 I-site; other site 216596016224 7 probable transmembrane helices predicted at aa 4-26, 33-50, 65-87, 96-118,122-141, 153-175 and 185-205 216596016225 Pfam match to entry PF00990.8 GGDEF 216596016226 1 probable transmembrane helix predicted at aa 7-29 216596016227 Uncharacterized conserved protein [Function unknown]; Region: COG3246 216596016228 Pfam match to entry PF05853.1 DUF849 216596016229 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596016230 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216596016231 putative substrate translocation pore; other site 216596016232 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596016233 14 probable transmembrane helices predicted at aa 21-43, 58-80, 87-109, 113-135,148-170, 174-196, 209-231, 241-263, 275-297, 312-334,341-363, 367-389, 410-429 and 444-466 216596016234 Pfam match to entry PF00083.9 Sugar_tr 216596016235 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596016236 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596016237 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 216596016238 putative substrate binding pocket [chemical binding]; other site 216596016239 putative dimerization interface [polypeptide binding]; other site 216596016240 Pfam match to entry PF00126.10 HTH_1 216596016241 Pfam match to entry PF03466.5 LysR_substrate 216596016242 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 216596016243 PhnA protein; Region: PhnA; pfam03831 216596016244 Pfam match to entry PF03831.3 PhnA 216596016245 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 216596016246 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 216596016247 Pfam match to entry PF01841.6 Transglut_core 216596016248 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 216596016249 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 216596016250 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 216596016251 Pfam match to entry PF01841.6 Transglut_core 216596016252 Predicted membrane protein [Function unknown]; Region: COG2261 216596016253 1 probable transmembrane helix predicted at aa 150-167 216596016254 SurA N-terminal domain; Region: SurA_N_3; cl07813 216596016255 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 216596016256 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 216596016257 1 probable transmembrane helix predicted at aa 12-31 216596016258 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 216596016259 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 216596016260 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 216596016261 Pfam match to entry PF02885.5 Glycos_trans_3N 216596016262 Pfam match to entry PF00591.9 Glycos_transf_3 216596016263 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 216596016264 active site 216596016265 ribulose/triose binding site [chemical binding]; other site 216596016266 phosphate binding site [ion binding]; other site 216596016267 substrate (anthranilate) binding pocket [chemical binding]; other site 216596016268 product (indole) binding pocket [chemical binding]; other site 216596016269 Pfam match to entry PF00218.10 IGPS 216596016270 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 216596016271 trimer interface [polypeptide binding]; other site 216596016272 dimer interface [polypeptide binding]; other site 216596016273 putative active site [active] 216596016274 Pfam match to entry PF01967.8 MoaC 216596016275 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 216596016276 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 216596016277 dimer interface [polypeptide binding]; other site 216596016278 putative functional site; other site 216596016279 putative MPT binding site; other site 216596016280 Pfam match to entry PF03453.5 MoeA_N 216596016281 Pfam match to entry PF00994.10 MoCF_biosynth 216596016282 Pfam match to entry PF03454.4 MoeA_C 216596016283 Predicted methyltransferase [General function prediction only]; Region: COG3897 216596016284 Cytochrome c; Region: Cytochrom_C; cl11414 216596016285 Pfam match to entry PF00034.8 Cytochrom_C 216596016286 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 216596016287 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 216596016288 catalytic loop [active] 216596016289 iron binding site [ion binding]; other site 216596016290 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 216596016291 Pfam match to entry PF00111.12 Fer2 216596016292 Pfam match to entry PF01799.6 Fer2_2 216596016293 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 216596016294 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 216596016295 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 216596016296 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 216596016297 Pfam match to entry PF02738.5 Ald_Xan_dh_C2 216596016298 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596016299 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596016300 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 216596016301 putative effector binding pocket; other site 216596016302 putative dimerization interface [polypeptide binding]; other site 216596016303 Pfam match to entry PF03466.5 LysR_substrate 216596016304 Pfam match to entry PF00126.10 HTH_1 216596016305 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 216596016306 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 216596016307 putative active site [active] 216596016308 putative FMN binding site [chemical binding]; other site 216596016309 putative substrate binding site [chemical binding]; other site 216596016310 putative catalytic residue [active] 216596016311 Pfam match to entry PF00724.7 Oxidored_FMN 216596016312 short chain dehydrogenase; Provisional; Region: PRK06180 216596016313 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 216596016314 NADP binding site [chemical binding]; other site 216596016315 active site 216596016316 steroid binding site; other site 216596016317 Pfam match to entry PF00106.11 adh_short 216596016318 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 216596016319 Pfam match to entry PF00583.9 Acetyltransf_1 216596016320 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 216596016321 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 216596016322 ATP binding site [chemical binding]; other site 216596016323 Mg++ binding site [ion binding]; other site 216596016324 motif III; other site 216596016325 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216596016326 nucleotide binding region [chemical binding]; other site 216596016327 ATP-binding site [chemical binding]; other site 216596016328 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 216596016329 RNA binding site [nucleotide binding]; other site 216596016330 Pfam match to entry PF03880.4 DbpA 216596016331 Pfam match to entry PF00271.13 Helicase_C 216596016332 Pfam match to entry PF00270.12 DEAD 216596016333 CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080 216596016334 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 216596016335 cyclase homology domain; Region: CHD; cd07302 216596016336 nucleotidyl binding site; other site 216596016337 metal binding site [ion binding]; metal-binding site 216596016338 dimer interface [polypeptide binding]; other site 216596016339 Pfam match to entry PF00211.9 Guanylate_cyc 216596016340 2 probable transmembrane helices predicted at aa 278-297 and 304-326 216596016341 Pfam match to entry PF05226.1 CHASE2 216596016342 FecR protein; Region: FecR; pfam04773 216596016343 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 216596016344 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102 216596016345 dimer interface [polypeptide binding]; other site 216596016346 active site 216596016347 coenzyme A binding site [chemical binding]; other site 216596016348 citrylCoA binding site [chemical binding]; other site 216596016349 oxalacetate/citrate binding site [chemical binding]; other site 216596016350 catalytic triad [active] 216596016351 Pfam match to entry PF00285.10 Citrate_synt 216596016352 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 216596016353 dimer interface [polypeptide binding]; other site 216596016354 Citrate synthase; Region: Citrate_synt; pfam00285 216596016355 active site 216596016356 citrylCoA binding site [chemical binding]; other site 216596016357 oxalacetate/citrate binding site [chemical binding]; other site 216596016358 coenzyme A binding site [chemical binding]; other site 216596016359 catalytic triad [active] 216596016360 Pfam match to entry PF00285.10 Citrate_synt 216596016361 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 216596016362 putative hydrophobic ligand binding site [chemical binding]; other site 216596016363 Pfam match to entry PF05146.3 DUF704 216596016364 CTP synthetase; Validated; Region: pyrG; PRK05380 216596016365 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 216596016366 Catalytic site [active] 216596016367 active site 216596016368 UTP binding site [chemical binding]; other site 216596016369 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 216596016370 active site 216596016371 putative oxyanion hole; other site 216596016372 catalytic triad [active] 216596016373 Pfam match to entry PF00117.10 GATase 216596016374 Pfam match to entry PF06418.1 CTP_synth_N 216596016375 1 probable transmembrane helix predicted at aa 17-39 216596016376 Pfam match to entry PF03840.3 SecG 216596016377 2 probable transmembrane helices predicted at aa 5-27 and 47-69 216596016378 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 216596016379 triosephosphate isomerase; Provisional; Region: PRK14565 216596016380 substrate binding site [chemical binding]; other site 216596016381 dimer interface [polypeptide binding]; other site 216596016382 catalytic triad [active] 216596016383 Pfam match to entry PF00121.7 TIM 216596016384 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 216596016385 1 probable transmembrane helix predicted at aa 55-77 216596016386 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 216596016387 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596016388 Mg2+ binding site [ion binding]; other site 216596016389 G-X-G motif; other site 216596016390 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 216596016391 anchoring element; other site 216596016392 dimer interface [polypeptide binding]; other site 216596016393 ATP binding site [chemical binding]; other site 216596016394 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 216596016395 active site 216596016396 metal binding site [ion binding]; metal-binding site 216596016397 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 216596016398 Pfam match to entry PF02518.9 HATPase_c 216596016399 Pfam match to entry PF00204.9 DNA_gyraseB 216596016400 Pfam match to entry PF00986.8 DNA_gyraseB_C 216596016401 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596016402 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596016403 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 216596016404 putative effector binding pocket; other site 216596016405 dimerization interface [polypeptide binding]; other site 216596016406 Pfam match to entry PF03466.5 LysR_substrate 216596016407 Pfam match to entry PF00126.10 HTH_1 216596016408 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 216596016409 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 216596016410 NAD(P) binding site [chemical binding]; other site 216596016411 Pfam match to entry PF00107.10 ADH_zinc_N 216596016412 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 216596016413 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 216596016414 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 216596016415 Domain of unknown function DUF20; Region: UPF0118; pfam01594 216596016416 Pfam match to entry PF01594.6 UPF0118 216596016417 8 probable transmembrane helices predicted at aa 35-66, 81-103, 175-197, 227-249,254-276, 286-308, 321-340 and 344-363 216596016418 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216596016419 Coenzyme A binding pocket [chemical binding]; other site 216596016420 Pfam match to entry PF00583.9 Acetyltransf_1 216596016421 DNA-damage-inducible protein J [DNA replication, recombination, and repair]; Region: RelB; COG3077 216596016422 Pfam match to entry PF04221.2 RelB 216596016423 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330 216596016424 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 216596016425 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 216596016426 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 216596016427 putative FMN binding site [chemical binding]; other site 216596016428 Pfam match to entry PF00881.10 Nitroreductase 216596016429 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 216596016430 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 216596016431 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 216596016432 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 216596016433 active site 216596016434 dimer interface [polypeptide binding]; other site 216596016435 motif 1; other site 216596016436 motif 2; other site 216596016437 motif 3; other site 216596016438 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 216596016439 anticodon binding site; other site 216596016440 Pfam match to entry PF03129.7 HGTP_anticodon 216596016441 Pfam match to entry PF00587.10 tRNA-synt_2b 216596016442 Pfam match to entry PF02824.6 TGS 216596016443 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 216596016444 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 216596016445 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 216596016446 trimerization site [polypeptide binding]; other site 216596016447 active site 216596016448 Pfam match to entry PF01592.6 NifU_N 216596016449 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 216596016450 GTP cyclohydrolase I; Provisional; Region: PLN03044 216596016451 active site 216596016452 Pfam match to entry PF01227.10 GTP_cyclohydroI 216596016453 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 216596016454 Pfam match to entry PF01502.6 PRA-CH 216596016455 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 216596016456 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 216596016457 active site 216596016458 nucleophile elbow; other site 216596016459 Pfam match to entry PF01734.8 Patatin 216596016460 FOG: CBS domain [General function prediction only]; Region: COG0517 216596016461 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 216596016462 Pfam match to entry PF00571.13 CBS 216596016463 Pfam match to entry PF00571.13 CBS 216596016464 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 216596016465 Pfam match to entry PF01694.8 Rhomboid 216596016466 6 probable transmembrane helices predicted at aa 91-113, 150-172, 179-201,206-228, 255-277 and 282-301 216596016467 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 216596016468 PAS domain; Region: PAS_5; pfam07310 216596016469 Pfam match to entry PF07310.1 DUF1457 216596016470 PilZ domain; Region: PilZ; pfam07238 216596016471 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 216596016472 Pfam match to entry PF00561.8 Abhydrolase_1 216596016473 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035 216596016474 1 probable transmembrane helix predicted at aa 7-29 216596016475 Pfam match to entry PF06035.1 DUF920 216596016476 1 probable transmembrane helix predicted at aa 23-45 216596016477 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 216596016478 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 216596016479 Sporulation related domain; Region: SPOR; pfam05036 216596016480 Pfam match to entry PF00768.8 Peptidase_S11 216596016481 Uncharacterized conserved protein [Function unknown]; Region: COG5458 216596016482 Pfam match to entry PF07370.1 DUF1489 216596016483 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 216596016484 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 216596016485 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 216596016486 Pfam match to entry PF03313.4 SDH_alpha 216596016487 Pfam match to entry PF03315.4 SDH_beta 216596016488 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 216596016489 putative dimer interface [polypeptide binding]; other site 216596016490 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216596016491 Pfam match to entry PF00903.11 Glyoxalase 216596016492 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 216596016493 Pfam match to entry PF01757.9 Acyl_transf_3 216596016494 10 probable transmembrane helices predicted at aa 12-34, 44-61, 81-103, 123-145,152-169, 174-193, 200-222, 232-249, 270-287 and 291-313 216596016495 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 216596016496 Pfam match to entry PF02502.6 LacAB_rpiB 216596016497 Pfam match to entry PF06562.1 DUF1124 216596016498 Predicted membrane protein [Function unknown]; Region: COG3821 216596016499 Pfam match to entry PF04654.2 DUF599 216596016500 4 probable transmembrane helices predicted at aa 4-23, 67-89, 109-131 and 190-212 216596016501 Predicted membrane protein [Function unknown]; Region: COG3503 216596016502 7 probable transmembrane helices predicted at aa 7-29, 39-61, 73-92, 96-115,117-134, 173-195 and 216-238 216596016503 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 216596016504 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 216596016505 DNA binding residues [nucleotide binding] 216596016506 putative dimer interface [polypeptide binding]; other site 216596016507 Pfam match to entry PF00376.9 MerR 216596016508 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 216596016509 MgtE intracellular N domain; Region: MgtE_N; smart00924 216596016510 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 216596016511 Divalent cation transporter; Region: MgtE; cl00786 216596016512 5 probable transmembrane helices predicted at aa 307-329, 334-353, 383-402,412-434 and 447-469 216596016513 Pfam match to entry PF01769.6 MgtE 216596016514 Pfam match to entry PF00571.13 CBS 216596016515 Pfam match to entry PF00571.13 CBS 216596016516 Pfam match to entry PF03448.5 MgtE_N 216596016517 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 216596016518 active site 216596016519 catalytic residues [active] 216596016520 metal binding site [ion binding]; metal-binding site 216596016521 Pfam match to entry PF01327.9 Pep_deformylase 216596016522 BON domain; Region: BON; pfam04972 216596016523 Pfam match to entry PF04972.3 BON 216596016524 1 probable transmembrane helix predicted at aa 5-27 216596016525 lipoate-protein ligase B; Provisional; Region: PRK14341 216596016526 Pfam match to entry PF03099.6 BPL_LipA_LipB 216596016527 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 216596016528 EamA-like transporter family; Region: EamA; pfam00892 216596016529 10 probable transmembrane helices predicted at aa 21-43, 53-75, 87-104, 109-131,136-155, 160-182, 191-213, 228-250, 257-279 and 289-304 216596016530 Pfam match to entry PF00892.8 DUF6 216596016531 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 216596016532 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 216596016533 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 216596016534 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 216596016535 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 216596016536 carboxyltransferase (CT) interaction site; other site 216596016537 biotinylation site [posttranslational modification]; other site 216596016538 Pfam match to entry PF00289.9 CPSase_L_chain 216596016539 Pfam match to entry PF02786.4 CPSase_L_D2 216596016540 Pfam match to entry PF02785.5 Biotin_carb_C 216596016541 Pfam match to entry PF00364.9 Biotin_lipoyl 216596016542 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216596016543 Coenzyme A binding pocket [chemical binding]; other site 216596016544 Pfam match to entry PF00583.9 Acetyltransf_1 216596016545 hypothetical protein; Validated; Region: PRK00124 216596016546 Pfam match to entry PF02639.4 DUF188 216596016547 multidrug efflux system protein; Provisional; Region: PRK11431 216596016548 Pfam match to entry PF00893.7 Multi_Drug_Res 216596016549 4 probable transmembrane helices predicted at aa 2-20, 30-49, 56-78 and 82-100 216596016550 Predicted membrane protein [Function unknown]; Region: COG2259 216596016551 Pfam match to entry PF04173.2 DoxD 216596016552 4 probable transmembrane helices predicted at aa 7-29, 44-66, 73-92 and 102-124 216596016553 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 216596016554 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 216596016555 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 216596016556 Pfam match to entry PF01039.9 Carboxyl_trans 216596016557 Chaperone required for the assembly of the mitochondrial F1-ATPase [Posttranslational modification, protein turnover, chaperones]; Region: COG5387 216596016558 Pfam match to entry PF07542.1 ATP12 216596016559 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 216596016560 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216596016561 motif II; other site 216596016562 Pfam match to entry PF00702.10 Hydrolase 216596016563 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 216596016564 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 216596016565 RNA binding surface [nucleotide binding]; other site 216596016566 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 216596016567 active site 216596016568 Pfam match to entry PF00849.9 PseudoU_synth_2 216596016569 camphor resistance protein CrcB; Provisional; Region: PRK14195 216596016570 Pfam match to entry PF02537.4 CRCB 216596016571 4 probable transmembrane helices predicted at aa 5-22, 32-54, 67-89 and 99-121 216596016572 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 216596016573 Protein of unknown function (DUF461); Region: DUF461; pfam04314 216596016574 Pfam match to entry PF04314.2 DUF461 216596016575 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 216596016576 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 216596016577 Pfam match to entry PF01571.8 GCV_T 216596016578 glycine dehydrogenase; Provisional; Region: PRK05367 216596016579 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 216596016580 tetramer interface [polypeptide binding]; other site 216596016581 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596016582 catalytic residue [active] 216596016583 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 216596016584 tetramer interface [polypeptide binding]; other site 216596016585 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596016586 catalytic residue [active] 216596016587 Pfam match to entry PF02347.5 GDC-P 216596016588 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 216596016589 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 216596016590 active site 216596016591 Pfam match to entry PF01183.9 Glyco_hydro_25 216596016592 flagellar basal body rod protein FlgC; Provisional; Region: flgC; PRK12632 216596016593 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 216596016594 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 216596016595 Pfam match to entry PF00460.8 Flg_bb_rod 216596016596 Pfam match to entry PF06429.1 DUF1078 216596016597 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 216596016598 Pfam match to entry PF01521.7 HesB 216596016599 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 216596016600 Pfam match to entry PF01883.7 DUF59 216596016601 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 216596016602 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 216596016603 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216596016604 catalytic residue [active] 216596016605 Pfam match to entry PF00266.8 Aminotran_5 216596016606 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 216596016607 FeS assembly protein SufD; Region: sufD; TIGR01981 216596016608 Pfam match to entry PF01458.7 UPF0051 216596016609 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 216596016610 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 216596016611 Walker A/P-loop; other site 216596016612 ATP binding site [chemical binding]; other site 216596016613 Q-loop/lid; other site 216596016614 ABC transporter signature motif; other site 216596016615 Walker B; other site 216596016616 D-loop; other site 216596016617 H-loop/switch region; other site 216596016618 Pfam match to entry PF00005.11 ABC_tran 216596016619 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 216596016620 putative ABC transporter; Region: ycf24; CHL00085 216596016621 Pfam match to entry PF01458.7 UPF0051 216596016622 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 216596016623 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 216596016624 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216596016625 catalytic residue [active] 216596016626 Pfam match to entry PF00266.8 Aminotran_5 216596016627 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 216596016628 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 216596016629 Pfam match to entry PF01757.9 Acyl_transf_3 216596016630 10 probable transmembrane helices predicted at aa 42-59, 69-91, 111-133, 173-195,202-224, 234-253, 260-279, 294-316, 323-345 and 351-373 216596016631 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 216596016632 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 216596016633 Pfam match to entry PF00583.9 Acetyltransf_1 216596016634 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 216596016635 Pfam match to entry PF03702.4 UPF0075 216596016636 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 216596016637 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 216596016638 active site 216596016639 HIGH motif; other site 216596016640 dimer interface [polypeptide binding]; other site 216596016641 KMSKS motif; other site 216596016642 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 216596016643 RNA binding surface [nucleotide binding]; other site 216596016644 Pfam match to entry PF00579.11 tRNA-synt_1b 216596016645 Pfam match to entry PF01479.9 S4 216596016646 Protein of unknown function; Region: DUF3971; pfam13116 216596016647 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 216596016648 1 probable transmembrane helix predicted at aa 63-82 216596016649 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 216596016650 catalytic triad [active] 216596016651 Pfam match to entry PF00578.7 AhpC-TSA 216596016652 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 216596016653 dinuclear metal binding motif [ion binding]; other site 216596016654 Pfam match to entry PF04305.2 DUF455 216596016655 Synaptobrevin; Region: Synaptobrevin; pfam00957 216596016656 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 216596016657 Peptidase family M23; Region: Peptidase_M23; pfam01551 216596016658 1 probable transmembrane helix predicted at aa 37-59 216596016659 Pfam match to entry PF01551.6 Peptidase_M23 216596016660 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 216596016661 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 216596016662 ATP binding site [chemical binding]; other site 216596016663 Mg++ binding site [ion binding]; other site 216596016664 motif III; other site 216596016665 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216596016666 nucleotide binding region [chemical binding]; other site 216596016667 ATP-binding site [chemical binding]; other site 216596016668 Pfam match to entry PF00270.12 DEAD 216596016669 Pfam match to entry PF00271.13 Helicase_C 216596016670 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 216596016671 nudix motif; other site 216596016672 Pfam match to entry PF00293.12 NUDIX 216596016673 TfoX N-terminal domain; Region: TfoX_N; pfam04993 216596016674 Pfam match to entry PF04993.3 TfoX_N 216596016675 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 216596016676 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 216596016677 ligand binding site [chemical binding]; other site 216596016678 Pfam match to entry PF01094.13 ANF_receptor 216596016679 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 216596016680 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 216596016681 substrate binding site [chemical binding]; other site 216596016682 hexamer interface [polypeptide binding]; other site 216596016683 metal binding site [ion binding]; metal-binding site 216596016684 Pfam match to entry PF00834.7 Ribul_P_3_epim 216596016685 Predicted secreted protein (DUF2259); Region: DUF2259; pfam10016 216596016686 1 probable transmembrane helix predicted at aa 5-27 216596016687 5 probable transmembrane helices predicted at aa 15-35, 48-70, 80-102, 109-131 and 135-157 216596016688 adenylosuccinate lyase; Provisional; Region: PRK07492 216596016689 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 216596016690 tetramer interface [polypeptide binding]; other site 216596016691 active site 216596016692 Pfam match to entry PF00206.9 Lyase_1 216596016693 Low affinity iron permease; Region: Iron_permease; cl12096 216596016694 Pfam match to entry PF07300.1 DUF1452 216596016695 2 probable transmembrane helices predicted at aa 38-57 and 62-84 216596016696 Predicted integral membrane protein [Function unknown]; Region: COG5473 216596016697 6 probable transmembrane helices predicted at aa 43-62, 72-94, 115-137, 171-193,213-235 and 239-258 216596016698 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 216596016699 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216596016700 Pfam match to entry PF06821.1 DUF1234 216596016701 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216596016702 PAS fold; Region: PAS_3; pfam08447 216596016703 putative active site [active] 216596016704 heme pocket [chemical binding]; other site 216596016705 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 216596016706 PAS fold; Region: PAS_3; pfam08447 216596016707 putative active site [active] 216596016708 heme pocket [chemical binding]; other site 216596016709 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 216596016710 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216596016711 metal binding site [ion binding]; metal-binding site 216596016712 active site 216596016713 I-site; other site 216596016714 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216596016715 Pfam match to entry PF00785.11 PAC 216596016716 Pfam match to entry PF00785.11 PAC 216596016717 Pfam match to entry PF00990.8 GGDEF 216596016718 Pfam match to entry PF00563.9 EAL 216596016719 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 216596016720 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 216596016721 ATP binding site [chemical binding]; other site 216596016722 active site 216596016723 substrate binding site [chemical binding]; other site 216596016724 Pfam match to entry PF01259.8 SAICAR_synt 216596016725 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 216596016726 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 216596016727 Pfam match to entry PF01885.6 PTS_2-RNA 216596016728 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 216596016729 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 216596016730 putative active site [active] 216596016731 catalytic triad [active] 216596016732 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 216596016733 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596016734 DNA-binding site [nucleotide binding]; DNA binding site 216596016735 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216596016736 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596016737 homodimer interface [polypeptide binding]; other site 216596016738 catalytic residue [active] 216596016739 Pfam match to entry PF00392.9 GntR 216596016740 Pfam match to entry PF00155.8 Aminotran_1_2 216596016741 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 216596016742 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 216596016743 dimerization interface [polypeptide binding]; other site 216596016744 ATP binding site [chemical binding]; other site 216596016745 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 216596016746 dimerization interface [polypeptide binding]; other site 216596016747 ATP binding site [chemical binding]; other site 216596016748 Pfam match to entry PF00586.11 AIRS 216596016749 Pfam match to entry PF02769.9 AIRS_C 216596016750 Pfam match to entry PF00586.11 AIRS 216596016751 Pfam match to entry PF02769.9 AIRS_C 216596016752 2 probable transmembrane helices predicted at aa 127-149 and 159-181 216596016753 Cytochrome c; Region: Cytochrom_C; pfam00034 216596016754 1 probable transmembrane helix predicted at aa 7-26 216596016755 Pfam match to entry PF00034.8 Cytochrom_C 216596016756 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 216596016757 putative GSH binding site [chemical binding]; other site 216596016758 catalytic residues [active] 216596016759 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596016760 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 216596016761 putative substrate translocation pore; other site 216596016762 12 probable transmembrane helices predicted at aa 20-42, 57-79, 86-108, 112-134,147-169, 173-195, 224-246, 256-278, 290-308, 318-340,347-369 and 379-401 216596016763 Pfam match to entry PF00083.9 Sugar_tr 216596016764 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596016765 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 216596016766 putative substrate translocation pore; other site 216596016767 12 probable transmembrane helices predicted at aa 17-39, 61-83, 90-112, 116-138,151-173, 177-199, 228-250, 265-287, 294-316, 321-343,350-372 and 382-404 216596016768 Pfam match to entry PF00083.9 Sugar_tr 216596016769 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 216596016770 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 216596016771 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216596016772 Coenzyme A binding pocket [chemical binding]; other site 216596016773 Pfam match to entry PF00583.9 Acetyltransf_1 216596016774 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 216596016775 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 216596016776 active site 216596016777 putative lithium-binding site [ion binding]; other site 216596016778 substrate binding site [chemical binding]; other site 216596016779 Pfam match to entry PF00459.10 Inositol_P 216596016780 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 216596016781 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 216596016782 active site 216596016783 putative lithium-binding site [ion binding]; other site 216596016784 substrate binding site [chemical binding]; other site 216596016785 Pfam match to entry PF00459.10 Inositol_P 216596016786 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 216596016787 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 216596016788 Ligand Binding Site [chemical binding]; other site 216596016789 Pfam match to entry PF01171.9 ATP_bind_3 216596016790 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 216596016791 glutaminase; Provisional; Region: PRK00971 216596016792 Pfam match to entry PF04960.4 Glutaminase 216596016793 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 216596016794 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 216596016795 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 216596016796 RNA binding surface [nucleotide binding]; other site 216596016797 Pfam match to entry PF01479.9 S4 216596016798 Pfam match to entry PF00163.7 Ribosomal_S4 216596016799 Domain of unknown function DUF87; Region: DUF87; pfam01935 216596016800 HerA helicase [Replication, recombination, and repair]; Region: COG0433 216596016801 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596016802 putative substrate translocation pore; other site 216596016803 12 probable transmembrane helices predicted at aa 30-49, 64-86, 93-110, 114-136,156-178, 182-201, 222-244, 259-278, 290-312, 316-338,350-372 and 377-399 216596016804 glutamate racemase; Provisional; Region: PRK00865 216596016805 Pfam match to entry PF01177.8 Asp_Glu_race 216596016806 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 216596016807 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 216596016808 Pfam match to entry PF00588.7 SpoU_methylase 216596016809 Predicted membrane protein [Function unknown]; Region: COG1289 216596016810 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 216596016811 10 probable transmembrane helices predicted at aa 29-48, 52-69, 78-97, 107-129,150-172, 383-400, 407-429, 433-450, 455-477 and 482-504 216596016812 isocitrate dehydrogenase; Validated; Region: PRK08299 216596016813 Pfam match to entry PF00180.7 Iso_dh 216596016814 putative acetyltransferase; Provisional; Region: PRK03624 216596016815 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216596016816 Coenzyme A binding pocket [chemical binding]; other site 216596016817 Pfam match to entry PF00583.9 Acetyltransf_1 216596016818 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 216596016819 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 216596016820 putative C-terminal domain interface [polypeptide binding]; other site 216596016821 putative GSH binding site (G-site) [chemical binding]; other site 216596016822 putative dimer interface [polypeptide binding]; other site 216596016823 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 216596016824 dimer interface [polypeptide binding]; other site 216596016825 N-terminal domain interface [polypeptide binding]; other site 216596016826 putative substrate binding pocket (H-site) [chemical binding]; other site 216596016827 Pfam match to entry PF02798.6 GST_N 216596016828 Pfam match to entry PF00043.11 GST_C 216596016829 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216596016830 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216596016831 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 216596016832 Pfam match to entry PF06445.1 AraC_E_bind 216596016833 Pfam match to entry PF00165.8 HTH_AraC 216596016834 Pfam match to entry PF00165.8 HTH_AraC 216596016835 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 216596016836 Pfam match to entry PF01810.7 LysE 216596016837 4 probable transmembrane helices predicted at aa 31-53, 68-85, 106-128 and 143-165 216596016838 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 216596016839 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 216596016840 motif 1; other site 216596016841 active site 216596016842 motif 2; other site 216596016843 motif 3; other site 216596016844 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 216596016845 DHHA1 domain; Region: DHHA1; pfam02272 216596016846 Pfam match to entry PF02272.6 DHHA1 216596016847 Pfam match to entry PF01411.6 tRNA-synt_2c 216596016848 recombinase A; Provisional; Region: recA; PRK09354 216596016849 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 216596016850 hexamer interface [polypeptide binding]; other site 216596016851 Walker A motif; other site 216596016852 ATP binding site [chemical binding]; other site 216596016853 Walker B motif; other site 216596016854 Pfam match to entry PF00154.7 RecA 216596016855 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 216596016856 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 216596016857 substrate binding site [chemical binding]; other site 216596016858 ATP binding site [chemical binding]; other site 216596016859 Pfam match to entry PF00294.10 PfkB 216596016860 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 216596016861 Pfam match to entry PF04227.2 Indigoidine_A 216596016862 PAS domain S-box; Region: sensory_box; TIGR00229 216596016863 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216596016864 putative active site [active] 216596016865 heme pocket [chemical binding]; other site 216596016866 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 216596016867 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 216596016868 putative active site [active] 216596016869 heme pocket [chemical binding]; other site 216596016870 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 216596016871 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216596016872 dimer interface [polypeptide binding]; other site 216596016873 phosphorylation site [posttranslational modification] 216596016874 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596016875 ATP binding site [chemical binding]; other site 216596016876 Mg2+ binding site [ion binding]; other site 216596016877 G-X-G motif; other site 216596016878 Response regulator receiver domain; Region: Response_reg; pfam00072 216596016879 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596016880 active site 216596016881 phosphorylation site [posttranslational modification] 216596016882 intermolecular recognition site; other site 216596016883 dimerization interface [polypeptide binding]; other site 216596016884 Pfam match to entry PF00072.9 Response_reg 216596016885 Pfam match to entry PF02518.9 HATPase_c 216596016886 Pfam match to entry PF00512.10 HisKA 216596016887 Pfam match to entry PF00989.11 PAS 216596016888 Pfam match to entry PF00989.11 PAS 216596016889 2 probable transmembrane helices predicted at aa 22-44 and 51-73 216596016890 1 probable transmembrane helix predicted at aa 15-37 216596016891 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 216596016892 Pfam match to entry PF06353.1 DUF1062 216596016893 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 216596016894 Pfam match to entry PF01258.7 zf-dskA_traR 216596016895 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 216596016896 catalytic core [active] 216596016897 Pfam match to entry PF00300.9 PGAM 216596016898 YcjX-like family, DUF463; Region: DUF463; pfam04317 216596016899 Pfam match to entry PF04317.2 DUF463 216596016900 Predicted membrane protein [Function unknown]; Region: COG3768 216596016901 Domain of unknown function (DUF697); Region: DUF697; cl12064 216596016902 Pfam match to entry PF05128.2 DUF697 216596016903 2 probable transmembrane helices predicted at aa 80-97 and 112-131 216596016904 1 probable transmembrane helix predicted at aa 7-29 216596016905 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 216596016906 catalytic center binding site [active] 216596016907 ATP binding site [chemical binding]; other site 216596016908 Pfam match to entry PF01288.8 HPPK 216596016909 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 216596016910 homooctamer interface [polypeptide binding]; other site 216596016911 active site 216596016912 Pfam match to entry PF02152.5 FolB 216596016913 dihydropteroate synthase; Region: DHPS; TIGR01496 216596016914 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 216596016915 substrate binding pocket [chemical binding]; other site 216596016916 dimer interface [polypeptide binding]; other site 216596016917 inhibitor binding site; inhibition site 216596016918 Pfam match to entry PF00809.8 Pterin_bind 216596016919 Bacterial protein of unknown function (DUF922); Region: DUF922; pfam06037 216596016920 Pfam match to entry PF06037.1 DUF922 216596016921 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 216596016922 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 216596016923 catalytic loop [active] 216596016924 iron binding site [ion binding]; other site 216596016925 Pfam match to entry PF00111.12 Fer2 216596016926 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 216596016927 putative binding surface; other site 216596016928 active site 216596016929 Pfam match to entry PF01627.9 Hpt 216596016930 chromosome segregation protein; Provisional; Region: PRK02224 216596016931 2 probable transmembrane helices predicted at aa 130-152 and 165-187 216596016932 Pfam match to entry PF02809.8 UIM 216596016933 Pfam match to entry PF02809.8 UIM 216596016934 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 216596016935 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 216596016936 Pfam match to entry PF00768.8 Peptidase_S11 216596016937 GAF domain; Region: GAF; pfam01590 216596016938 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 216596016939 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 216596016940 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216596016941 metal binding site [ion binding]; metal-binding site 216596016942 active site 216596016943 I-site; other site 216596016944 Pfam match to entry PF00990.8 GGDEF 216596016945 Pfam match to entry PF01590.11 GAF 216596016946 ABC-type uncharacterized transport system, auxiliary component [General function prediction only]; Region: COG3218 216596016947 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 216596016948 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 216596016949 mce related protein; Region: MCE; pfam02470 216596016950 Pfam match to entry PF02470.6 MCE 216596016951 1 probable transmembrane helix predicted at aa 7-29 216596016952 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 216596016953 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 216596016954 Walker A/P-loop; other site 216596016955 ATP binding site [chemical binding]; other site 216596016956 Q-loop/lid; other site 216596016957 ABC transporter signature motif; other site 216596016958 Walker B; other site 216596016959 D-loop; other site 216596016960 H-loop/switch region; other site 216596016961 Pfam match to entry PF00005.11 ABC_tran 216596016962 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 216596016963 anti sigma factor interaction site; other site 216596016964 regulatory phosphorylation site [posttranslational modification]; other site 216596016965 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 216596016966 Permease; Region: Permease; pfam02405 216596016967 6 probable transmembrane helices predicted at aa 182-204, 219-241, 262-284,288-310, 323-345 and 365-387 216596016968 Pfam match to entry PF02405.5 DUF140 216596016969 Pfam match to entry PF01740.8 STAS 216596016970 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 216596016971 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 216596016972 active site 216596016973 Pfam match to entry PF02746.4 MR_MLE_N 216596016974 Pfam match to entry PF01188.9 MR_MLE 216596016975 1 probable transmembrane helix predicted at aa 266-288 216596016976 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 216596016977 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596016978 putative substrate translocation pore; other site 216596016979 10 probable transmembrane helices predicted at aa 21-43, 53-75, 84-106, 111-133,146-163, 167-189, 280-297, 302-321, 342-364 and 369-391 216596016980 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 216596016981 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 216596016982 putative active site [active] 216596016983 putative metal binding site [ion binding]; other site 216596016984 Pfam match to entry PF00149.12 Metallophos 216596016985 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 216596016986 catalytic core [active] 216596016987 Pfam match to entry PF00300.9 PGAM 216596016988 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 216596016989 Protein export membrane protein; Region: SecD_SecF; cl14618 216596016990 Pfam match to entry PF00873.7 ACR_tran 216596016991 12 probable transmembrane helices predicted at aa 13-35, 340-359, 366-388, 392-414,438-460, 475-497, 538-560, 866-885, 890-912, 922-941,962-984 and 999-1021 216596016992 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 216596016993 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 216596016994 HlyD family secretion protein; Region: HlyD_3; pfam13437 216596016995 Pfam match to entry PF00529.8 HlyD 216596016996 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216596016997 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216596016998 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 216596016999 FAD binding domain; Region: FAD_binding_4; pfam01565 216596017000 Berberine and berberine like; Region: BBE; pfam08031 216596017001 Pfam match to entry PF01565.10 FAD_binding_4 216596017002 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596017003 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596017004 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 216596017005 putative effector binding pocket; other site 216596017006 dimerization interface [polypeptide binding]; other site 216596017007 Pfam match to entry PF03466.5 LysR_substrate 216596017008 Pfam match to entry PF00126.10 HTH_1 216596017009 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 216596017010 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 216596017011 Pfam match to entry PF03807.3 F420_oxidored 216596017012 malic enzyme; Reviewed; Region: PRK12862 216596017013 Malic enzyme, N-terminal domain; Region: malic; pfam00390 216596017014 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 216596017015 putative NAD(P) binding site [chemical binding]; other site 216596017016 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 216596017017 Pfam match to entry PF00390.8 malic 216596017018 Pfam match to entry PF03949.3 Malic_M 216596017019 Pfam match to entry PF01515.8 PTA_PTB 216596017020 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 216596017021 RNA/DNA hybrid binding site [nucleotide binding]; other site 216596017022 active site 216596017023 Pfam match to entry PF00075.10 RnaseH 216596017024 Protein of unknown function (DUF2865); Region: DUF2865; pfam11064 216596017025 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 216596017026 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216596017027 NAD(P) binding site [chemical binding]; other site 216596017028 active site 216596017029 Pfam match to entry PF00106.11 adh_short 216596017030 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 216596017031 active site 216596017032 Int/Topo IB signature motif; other site 216596017033 DNA binding site [nucleotide binding] 216596017034 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 216596017035 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 216596017036 active site 216596017037 DNA binding site [nucleotide binding] 216596017038 Int/Topo IB signature motif; other site 216596017039 Pfam match to entry PF02899.5 Phage_integr_N 216596017040 Pfam match to entry PF00589.8 Phage_integrase 216596017041 Pfam match to entry PF00589.8 Phage_integrase 216596017042 Domain of unknown function (DUF4375); Region: DUF4375; pfam14300 216596017043 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 216596017044 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 216596017045 Putative transposase; Region: Y2_Tnp; pfam04986 216596017046 Pfam match to entry PF04986.3 Transposase_32 216596017047 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 216596017048 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 216596017049 Int/Topo IB signature motif; other site 216596017050 Pfam match to entry PF00589.8 Phage_integrase 216596017051 Pfam match to entry PF02899.5 Phage_integr_N 216596017052 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 216596017053 putative FMN binding site [chemical binding]; other site 216596017054 Pfam match to entry PF00881.10 Nitroreductase 216596017055 putative transporter; Provisional; Region: PRK10504 216596017056 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596017057 putative substrate translocation pore; other site 216596017058 11 probable transmembrane helices predicted at aa 117-139, 154-176, 209-231,235-257, 270-292, 296-318, 339-361, 397-419, 426-448,468-490 and 502-524 216596017059 Pfam match to entry PF00083.9 Sugar_tr 216596017060 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 216596017061 dimerization interface [polypeptide binding]; other site 216596017062 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216596017063 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 216596017064 dimer interface [polypeptide binding]; other site 216596017065 putative CheW interface [polypeptide binding]; other site 216596017066 2 probable transmembrane helices predicted at aa 10-32 and 171-193 216596017067 Pfam match to entry PF00672.10 HAMP 216596017068 Pfam match to entry PF00015.9 MCPsignal 216596017069 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 216596017070 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 216596017071 Pfam match to entry PF00793.9 DAHP_synth_1 216596017072 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 216596017073 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 216596017074 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 216596017075 NAD synthetase; Provisional; Region: PRK13981 216596017076 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 216596017077 multimer interface [polypeptide binding]; other site 216596017078 active site 216596017079 catalytic triad [active] 216596017080 protein interface 1 [polypeptide binding]; other site 216596017081 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 216596017082 homodimer interface [polypeptide binding]; other site 216596017083 NAD binding pocket [chemical binding]; other site 216596017084 ATP binding pocket [chemical binding]; other site 216596017085 Mg binding site [ion binding]; other site 216596017086 active-site loop [active] 216596017087 Pfam match to entry PF02540.4 NAD_synthase 216596017088 Pfam match to entry PF00795.10 CN_hydrolase 216596017089 Predicted membrane protein [Function unknown]; Region: COG4420 216596017090 Pfam match to entry PF06210.1 DUF1003 216596017091 2 probable transmembrane helices predicted at aa 63-85 and 95-117 216596017092 Uncharacterized conserved protein [Function unknown]; Region: COG3791 216596017093 Pfam match to entry PF04828.3 DUF636 216596017094 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 216596017095 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 216596017096 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 216596017097 Walker A/P-loop; other site 216596017098 ATP binding site [chemical binding]; other site 216596017099 Q-loop/lid; other site 216596017100 ABC transporter signature motif; other site 216596017101 Walker B; other site 216596017102 D-loop; other site 216596017103 H-loop/switch region; other site 216596017104 3 probable transmembrane helices predicted at aa 49-71, 91-113 and 187-209 216596017105 Pfam match to entry PF00664.9 ABC_membrane 216596017106 Pfam match to entry PF00005.11 ABC_tran 216596017107 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 216596017108 Pfam match to entry PF01474.5 DAHP_synth_2 216596017109 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 216596017110 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 216596017111 1 probable transmembrane helix predicted at aa 13-35 216596017112 glutathione reductase; Validated; Region: PRK06116 216596017113 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 216596017114 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 216596017115 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 216596017116 Pfam match to entry PF02852.6 Pyr_redox_dim 216596017117 Pfam match to entry PF00070.12 Pyr_redox 216596017118 acylphosphatase; Provisional; Region: PRK14425 216596017119 Pfam match to entry PF00708.7 Acylphosphatase 216596017120 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3184 216596017121 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 216596017122 tetramer (dimer of dimers) interface [polypeptide binding]; other site 216596017123 active site 216596017124 dimer interface [polypeptide binding]; other site 216596017125 Pfam match to entry PF06026.2 Rib_5-P_isom_A 216596017126 Pfam match to entry PF00455.10 DeoR 216596017127 phosphoglycolate phosphatase; Provisional; Region: PRK13222 216596017128 Acid Phosphatase; Region: Acid_PPase; cl17256 216596017129 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216596017130 motif II; other site 216596017131 Pfam match to entry PF00702.10 Hydrolase 216596017132 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 216596017133 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 216596017134 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 216596017135 1 probable transmembrane helix predicted at aa 7-29 216596017136 fumarate hydratase; Reviewed; Region: fumC; PRK00485 216596017137 Class II fumarases; Region: Fumarase_classII; cd01362 216596017138 active site 216596017139 tetramer interface [polypeptide binding]; other site 216596017140 Pfam match to entry PF00206.9 Lyase_1 216596017141 VCBS repeat; Region: VCBS_repeat; TIGR01965 216596017142 fumarate hydratase; Provisional; Region: PRK15389 216596017143 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 216596017144 Fumarase C-terminus; Region: Fumerase_C; pfam05683 216596017145 Pfam match to entry PF05681.2 Fumerase 216596017146 Pfam match to entry PF05683.1 Fumerase_C 216596017147 1 probable transmembrane helix predicted at aa 21-39 216596017148 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 216596017149 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216596017150 metal binding site [ion binding]; metal-binding site 216596017151 active site 216596017152 I-site; other site 216596017153 Pfam match to entry PF00990.8 GGDEF 216596017154 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 216596017155 Pfam match to entry PF01243.8 Pyridox_oxidase 216596017156 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 216596017157 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216596017158 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 216596017159 MarR family; Region: MarR; pfam01047 216596017160 Pfam match to entry PF01047.8 MarR 216596017161 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 216596017162 Pfam match to entry PF06772.1 LtrA 216596017163 11 probable transmembrane helices predicted at aa 21-39, 54-76, 83-105, 110-127,140-159, 169-191, 211-230, 235-257, 282-304, 314-333 and 346-380 216596017164 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 216596017165 Pfam match to entry PF06155.1 DUF971 216596017166 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 216596017167 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 216596017168 FeS/SAM binding site; other site 216596017169 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 216596017170 Pfam match to entry PF04055.4 Radical_SAM 216596017171 Pfam match to entry PF06463.1 Mob_synth_C 216596017172 Methyltransferase domain; Region: Methyltransf_23; pfam13489 216596017173 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596017174 S-adenosylmethionine binding site [chemical binding]; other site 216596017175 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 216596017176 Pfam match to entry PF01209.8 Ubie_methyltran 216596017177 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 216596017178 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 216596017179 putative ligand binding residues [chemical binding]; other site 216596017180 1 probable transmembrane helix predicted at aa 7-29 216596017181 Pfam match to entry PF01497.7 Peripla_BP_2 216596017182 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 216596017183 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 216596017184 ABC-ATPase subunit interface; other site 216596017185 dimer interface [polypeptide binding]; other site 216596017186 putative PBP binding regions; other site 216596017187 9 probable transmembrane helices predicted at aa 26-48, 74-96, 109-131, 136-158,171-193, 213-232, 264-286, 301-320 and 327-349 216596017188 Pfam match to entry PF01032.7 FecCD 216596017189 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 216596017190 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 216596017191 Walker A/P-loop; other site 216596017192 ATP binding site [chemical binding]; other site 216596017193 Q-loop/lid; other site 216596017194 ABC transporter signature motif; other site 216596017195 Walker B; other site 216596017196 D-loop; other site 216596017197 H-loop/switch region; other site 216596017198 Pfam match to entry PF00005.11 ABC_tran 216596017199 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 216596017200 MarR family; Region: MarR_2; pfam12802 216596017201 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 216596017202 Pfam match to entry PF04198.2 Sugar-bind 216596017203 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 216596017204 bacterial glycerol kinase 2-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GK2_bacteria; cd07791 216596017205 N- and C-terminal domain interface [polypeptide binding]; other site 216596017206 active site 216596017207 MgATP binding site [chemical binding]; other site 216596017208 catalytic site [active] 216596017209 metal binding site [ion binding]; metal-binding site 216596017210 putative homotetramer interface [polypeptide binding]; other site 216596017211 putative homodimer interface [polypeptide binding]; other site 216596017212 glycerol binding site [chemical binding]; other site 216596017213 Pfam match to entry PF02782.4 FGGY_C 216596017214 Pfam match to entry PF00370.9 FGGY_N 216596017215 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 216596017216 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 216596017217 PYR/PP interface [polypeptide binding]; other site 216596017218 dimer interface [polypeptide binding]; other site 216596017219 TPP binding site [chemical binding]; other site 216596017220 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 216596017221 Pfam match to entry PF02780.6 Transketolase_C 216596017222 Pfam match to entry PF02779.8 Transket_pyr 216596017223 transketolase; Reviewed; Region: PRK05899 216596017224 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 216596017225 TPP-binding site [chemical binding]; other site 216596017226 dimer interface [polypeptide binding]; other site 216596017227 Pfam match to entry PF00456.9 Transketolase_N 216596017228 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596017229 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216596017230 TM-ABC transporter signature motif; other site 216596017231 7 probable transmembrane helices predicted at aa 24-46, 58-80, 100-122, 169-191,221-243, 264-286 and 301-320 216596017232 Pfam match to entry PF02653.5 BPD_transp_2 216596017233 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 216596017234 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 216596017235 ligand binding site [chemical binding]; other site 216596017236 Pfam match to entry PF00532.8 Peripla_BP_1 216596017237 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 216596017238 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 216596017239 Walker A/P-loop; other site 216596017240 ATP binding site [chemical binding]; other site 216596017241 Q-loop/lid; other site 216596017242 ABC transporter signature motif; other site 216596017243 Walker B; other site 216596017244 D-loop; other site 216596017245 H-loop/switch region; other site 216596017246 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 216596017247 Pfam match to entry PF00005.11 ABC_tran 216596017248 Pfam match to entry PF00005.11 ABC_tran 216596017249 short chain dehydrogenase; Provisional; Region: PRK06114 216596017250 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216596017251 NAD(P) binding site [chemical binding]; other site 216596017252 active site 216596017253 Pfam match to entry PF00106.11 adh_short 216596017254 Similar to Shigella flexneri tpia triosephosphate isomerase (ec 5.3.1.1) (tim) (triose-phosphate isomerase). UniProt:TPIS_ECOLI (EMBL:AE016770) (255 aa), and to Agrobacterium rhizogenes riorf86 triosephosphate isomerase (ec 5.3.1.1) (tim). UniProt:Q9KW98_AGRRH (EMBL:AB039932) (250 aa); similarity:fasta; with=UniProt:TPIS_ECOLI (EMBL:AE016770); Shigella flexneri.; tpiA; Triosephosphate isomerase (EC 5.3.1.1) (TIM) (Triose-phosphate isomerase).; length=255; id 34.921; 63 aa overlap; query 7-69; subject 8-65; similarity:fasta; with=UniProt:Q9KW98_AGRRH (EMBL:AB039932); Agrobacterium rhizogenes.; riorf86; Triosephosphate isomerase (EC 5.3.1.1) (TIM).; length=250; id 47.273; 55 aa overlap; query 16-70; subject 13-67; triosephosphate isomerase, pseudogene 216596017255 Pfam match to entry PF00121.7 TIM 216596017256 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 216596017257 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216596017258 NAD(P) binding site [chemical binding]; other site 216596017259 active site 216596017260 Pfam match to entry PF00106.11 adh_short 216596017261 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 216596017262 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 216596017263 Pfam match to entry PF00926.7 DHBP_synthase 216596017264 short chain dehydrogenase; Provisional; Region: PRK07478 216596017265 classical (c) SDRs; Region: SDR_c; cd05233 216596017266 NAD(P) binding site [chemical binding]; other site 216596017267 active site 216596017268 Pfam match to entry PF00106.11 adh_short 216596017269 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 216596017270 9 probable transmembrane helices predicted at aa 10-32, 39-56, 71-93, 100-122,137-159, 178-200, 210-232, 239-261 and 265-282 216596017271 Pfam match to entry PF00892.8 DUF6 216596017272 Pfam match to entry PF00892.8 DUF6 216596017273 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 216596017274 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 216596017275 GTP binding site; other site 216596017276 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 216596017277 Walker A motif; other site 216596017278 Pfam match to entry PF03205.3 MobB 216596017279 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216596017280 PAS fold; Region: PAS_3; pfam08447 216596017281 putative active site [active] 216596017282 heme pocket [chemical binding]; other site 216596017283 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596017284 ATP binding site [chemical binding]; other site 216596017285 G-X-G motif; other site 216596017286 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 216596017287 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596017288 active site 216596017289 phosphorylation site [posttranslational modification] 216596017290 intermolecular recognition site; other site 216596017291 dimerization interface [polypeptide binding]; other site 216596017292 Pfam match to entry PF00072.9 Response_reg 216596017293 Pfam match to entry PF02518.9 HATPase_c 216596017294 Pfam match to entry PF00512.10 HisKA 216596017295 Pfam match to entry PF00785.11 PAC 216596017296 circadian clock protein KaiC; Reviewed; Region: PRK09302 216596017297 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 216596017298 Walker A motif; other site 216596017299 ATP binding site [chemical binding]; other site 216596017300 Walker B motif; other site 216596017301 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 216596017302 Walker A motif; other site 216596017303 ATP binding site [chemical binding]; other site 216596017304 Walker B motif; other site 216596017305 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596017306 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596017307 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 216596017308 putative effector binding pocket; other site 216596017309 putative dimerization interface [polypeptide binding]; other site 216596017310 Pfam match to entry PF03466.5 LysR_substrate 216596017311 Pfam match to entry PF00126.10 HTH_1 216596017312 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 216596017313 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 216596017314 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 216596017315 active site 216596017316 catalytic tetrad [active] 216596017317 Pfam match to entry PF00248.9 Aldo_ket_red 216596017318 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 216596017319 maleylacetoacetate isomerase; Region: maiA; TIGR01262 216596017320 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 216596017321 N-terminal domain interface [polypeptide binding]; other site 216596017322 Pfam match to entry PF00043.11 GST_C 216596017323 Pfam match to entry PF02798.6 GST_N 216596017324 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 216596017325 Pfam match to entry PF02566.5 OsmC 216596017326 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 216596017327 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 216596017328 dimerization interface [polypeptide binding]; other site 216596017329 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216596017330 dimer interface [polypeptide binding]; other site 216596017331 phosphorylation site [posttranslational modification] 216596017332 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596017333 ATP binding site [chemical binding]; other site 216596017334 Mg2+ binding site [ion binding]; other site 216596017335 G-X-G motif; other site 216596017336 Pfam match to entry PF02518.9 HATPase_c 216596017337 Pfam match to entry PF00512.10 HisKA 216596017338 Pfam match to entry PF00672.10 HAMP 216596017339 2 probable transmembrane helices predicted at aa 15-34 and 153-175 216596017340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596017341 osmolarity response regulator; Provisional; Region: ompR; PRK09468 216596017342 active site 216596017343 phosphorylation site [posttranslational modification] 216596017344 intermolecular recognition site; other site 216596017345 dimerization interface [polypeptide binding]; other site 216596017346 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216596017347 DNA binding site [nucleotide binding] 216596017348 Pfam match to entry PF00486.11 Trans_reg_C 216596017349 Pfam match to entry PF00072.9 Response_reg 216596017350 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 216596017351 Pfam match to entry PF00561.8 Abhydrolase_1 216596017352 1 probable transmembrane helix predicted at aa 12-34 216596017353 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 216596017354 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 216596017355 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 216596017356 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 216596017357 catalytic residues [active] 216596017358 5 probable transmembrane helices predicted at aa 72-94, 109-131, 189-211, 226-245 and 265-287 216596017359 Pfam match to entry PF02683.4 DsbD 216596017360 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216596017361 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 216596017362 1 probable transmembrane helix predicted at aa 5-27 216596017363 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 216596017364 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 216596017365 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 216596017366 Pfam match to entry PF00455.10 DeoR 216596017367 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 216596017368 intersubunit interface [polypeptide binding]; other site 216596017369 active site 216596017370 catalytic residue [active] 216596017371 Pfam match to entry PF01791.6 DeoC 216596017372 Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111 216596017373 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 216596017374 NAD(P) binding site [chemical binding]; other site 216596017375 catalytic residues [active] 216596017376 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 216596017377 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 216596017378 NAD(P) binding site [chemical binding]; other site 216596017379 Pfam match to entry PF00171.9 Aldedh 216596017380 Pfam match to entry PF00171.9 Aldedh 216596017381 Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154 216596017382 Pfam match to entry PF05025.2 RbsD_FucU 216596017383 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 216596017384 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 216596017385 substrate binding site [chemical binding]; other site 216596017386 dimer interface [polypeptide binding]; other site 216596017387 ATP binding site [chemical binding]; other site 216596017388 Pfam match to entry PF00294.10 PfkB 216596017389 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 216596017390 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 216596017391 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596017392 dimer interface [polypeptide binding]; other site 216596017393 putative PBP binding loops; other site 216596017394 ABC-ATPase subunit interface; other site 216596017395 7 probable transmembrane helices predicted at aa 10-32, 63-85, 100-122, 157-179,199-221, 228-250 and 260-282 216596017396 Pfam match to entry PF00528.10 BPD_transp_1 216596017397 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216596017398 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596017399 dimer interface [polypeptide binding]; other site 216596017400 conserved gate region; other site 216596017401 putative PBP binding loops; other site 216596017402 ABC-ATPase subunit interface; other site 216596017403 9 probable transmembrane helices predicted at aa 12-34, 44-66, 73-95, 105-127,132-154, 169-191, 203-225, 264-286 and 307-329 216596017404 Pfam match to entry PF00528.10 BPD_transp_1 216596017405 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 216596017406 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 216596017407 Pfam match to entry PF01547.11 SBP_bac_1 216596017408 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 216596017409 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 216596017410 Walker A/P-loop; other site 216596017411 ATP binding site [chemical binding]; other site 216596017412 Q-loop/lid; other site 216596017413 ABC transporter signature motif; other site 216596017414 Walker B; other site 216596017415 D-loop; other site 216596017416 H-loop/switch region; other site 216596017417 TOBE domain; Region: TOBE_2; pfam08402 216596017418 Pfam match to entry PF00005.11 ABC_tran 216596017419 Pfam match to entry PF03459.4 TOBE 216596017420 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 216596017421 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 216596017422 ligand binding site [chemical binding]; other site 216596017423 Pfam match to entry PF00691.7 OmpA 216596017424 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 216596017425 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 216596017426 substrate binding pocket [chemical binding]; other site 216596017427 membrane-bound complex binding site; other site 216596017428 hinge residues; other site 216596017429 Pfam match to entry PF00497.8 SBP_bac_3 216596017430 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 216596017431 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596017432 dimer interface [polypeptide binding]; other site 216596017433 conserved gate region; other site 216596017434 putative PBP binding loops; other site 216596017435 ABC-ATPase subunit interface; other site 216596017436 6 probable transmembrane helices predicted at aa 13-35, 55-77, 102-124, 139-161,182-204 and 235-257 216596017437 Pfam match to entry PF00528.10 BPD_transp_1 216596017438 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 216596017439 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596017440 dimer interface [polypeptide binding]; other site 216596017441 conserved gate region; other site 216596017442 putative PBP binding loops; other site 216596017443 ABC-ATPase subunit interface; other site 216596017444 6 probable transmembrane helices predicted at aa 28-50, 65-87, 100-122, 137-159,210-229 and 244-266 216596017445 Pfam match to entry PF00528.10 BPD_transp_1 216596017446 Usg protein, probable subunit of phosphoribosylanthranilate isomerase [Amino acid transport and metabolism]; Region: COG5425 216596017447 Pfam match to entry PF06233.1 Usg 216596017448 Predicted integral membrane protein [Function unknown]; Region: COG5530 216596017449 4 probable transmembrane helices predicted at aa 65-84, 89-111, 170-187 and 210-232 216596017450 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 216596017451 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596017452 Pfam match to entry PF00515.11 TPR 216596017453 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 216596017454 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 216596017455 C-terminal domain interface [polypeptide binding]; other site 216596017456 GSH binding site (G-site) [chemical binding]; other site 216596017457 dimer interface [polypeptide binding]; other site 216596017458 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 216596017459 N-terminal domain interface [polypeptide binding]; other site 216596017460 dimer interface [polypeptide binding]; other site 216596017461 substrate binding pocket (H-site) [chemical binding]; other site 216596017462 Pfam match to entry PF02798.6 GST_N 216596017463 Pfam match to entry PF00043.11 GST_C 216596017464 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216596017465 dimerization interface [polypeptide binding]; other site 216596017466 putative DNA binding site [nucleotide binding]; other site 216596017467 putative Zn2+ binding site [ion binding]; other site 216596017468 Pfam match to entry PF01022.8 HTH_5 216596017469 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_7; cd08900 216596017470 putative hydrophobic ligand binding site [chemical binding]; other site 216596017471 Pfam match to entry PF05146.3 DUF704 216596017472 Uncharacterized conserved protein [Function unknown]; Region: COG5649 216596017473 Uncharacterized conserved protein [Function unknown]; Region: COG5649 216596017474 2 probable transmembrane helices predicted at aa 20-37 and 42-64 216596017475 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 216596017476 putative hydrophobic ligand binding site [chemical binding]; other site 216596017477 Pfam match to entry PF05146.3 DUF704 216596017478 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216596017479 dimerization interface [polypeptide binding]; other site 216596017480 putative DNA binding site [nucleotide binding]; other site 216596017481 putative Zn2+ binding site [ion binding]; other site 216596017482 Pfam match to entry PF01022.8 HTH_5 216596017483 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 216596017484 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 216596017485 Walker A/P-loop; other site 216596017486 ATP binding site [chemical binding]; other site 216596017487 Q-loop/lid; other site 216596017488 ABC transporter signature motif; other site 216596017489 Walker B; other site 216596017490 D-loop; other site 216596017491 H-loop/switch region; other site 216596017492 Pfam match to entry PF00005.11 ABC_tran 216596017493 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 216596017494 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596017495 dimer interface [polypeptide binding]; other site 216596017496 conserved gate region; other site 216596017497 putative PBP binding loops; other site 216596017498 ABC-ATPase subunit interface; other site 216596017499 Pfam match to entry PF00528.10 BPD_transp_1 216596017500 6 probable transmembrane helices predicted at aa 32-54, 87-109, 121-143, 148-170,192-214 and 243-265 216596017501 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 216596017502 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 216596017503 active site 216596017504 dimer interface [polypeptide binding]; other site 216596017505 non-prolyl cis peptide bond; other site 216596017506 insertion regions; other site 216596017507 Pfam match to entry PF00296.10 Bac_luciferase 216596017508 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 216596017509 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 216596017510 membrane-bound complex binding site; other site 216596017511 hinge residues; other site 216596017512 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 216596017513 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 216596017514 Pfam match to entry PF03446.3 NAD_binding_2 216596017515 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 216596017516 A new structural DNA glycosylase; Region: AlkD_like; cd06561 216596017517 active site 216596017518 LysR family transcriptional regulator; Provisional; Region: PRK14997 216596017519 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596017520 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216596017521 dimerization interface [polypeptide binding]; other site 216596017522 Pfam match to entry PF03466.5 LysR_substrate 216596017523 Pfam match to entry PF00126.10 HTH_1 216596017524 Porin subfamily; Region: Porin_2; pfam02530 216596017525 Pfam match to entry PF02530.4 Porin_2 216596017526 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 216596017527 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216596017528 putative DNA binding site [nucleotide binding]; other site 216596017529 putative Zn2+ binding site [ion binding]; other site 216596017530 AsnC family; Region: AsnC_trans_reg; pfam01037 216596017531 Pfam match to entry PF01037.8 AsnC_trans_reg 216596017532 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 216596017533 putative uracil binding site [chemical binding]; other site 216596017534 putative active site [active] 216596017535 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 216596017536 Catalytic site; other site 216596017537 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 216596017538 Pfam match to entry PF00565.7 SNase 216596017539 1 probable transmembrane helix predicted at aa 7-26 216596017540 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 216596017541 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216596017542 dimer interface [polypeptide binding]; other site 216596017543 phosphorylation site [posttranslational modification] 216596017544 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596017545 ATP binding site [chemical binding]; other site 216596017546 Mg2+ binding site [ion binding]; other site 216596017547 G-X-G motif; other site 216596017548 5 probable transmembrane helices predicted at aa 60-82, 87-104, 124-143, 158-180 and 199-218 216596017549 Pfam match to entry PF00512.10 HisKA 216596017550 Pfam match to entry PF02518.9 HATPase_c 216596017551 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 216596017552 Pfam match to entry PF01219.8 DAGK_prokar 216596017553 2 probable transmembrane helices predicted at aa 90-112 and 144-163 216596017554 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 216596017555 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 216596017556 putative dimer interface [polypeptide binding]; other site 216596017557 active site pocket [active] 216596017558 putative cataytic base [active] 216596017559 Pfam match to entry PF02277.6 DBI_PRT 216596017560 cobalamin synthase; Reviewed; Region: cobS; PRK00235 216596017561 Predicted aspartyl protease [General function prediction only]; Region: COG3577 216596017562 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 216596017563 catalytic motif [active] 216596017564 Catalytic residue [active] 216596017565 3 probable transmembrane helices predicted at aa 2-20, 35-54 and 67-84 216596017566 5 probable transmembrane helices predicted at aa 4-23, 35-57, 67-89, 98-120 and 125-144 216596017567 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596017568 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596017569 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 216596017570 dimerization interface [polypeptide binding]; other site 216596017571 Pfam match to entry PF00126.10 HTH_1 216596017572 Pfam match to entry PF03466.5 LysR_substrate 216596017573 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 216596017574 short chain dehydrogenase; Provisional; Region: PRK07041 216596017575 putative NAD(P) binding site [chemical binding]; other site 216596017576 homodimer interface [polypeptide binding]; other site 216596017577 Pfam match to entry PF00106.11 adh_short 216596017578 ABC-2 type transporter; Region: ABC2_membrane; cl17235 216596017579 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 216596017580 Pfam match to entry PF01061.7 ABC2_membrane 216596017581 6 probable transmembrane helices predicted at aa 21-43, 63-82, 103-125, 140-162,169-191 and 223-245 216596017582 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 216596017583 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 216596017584 Walker A/P-loop; other site 216596017585 ATP binding site [chemical binding]; other site 216596017586 Q-loop/lid; other site 216596017587 ABC transporter signature motif; other site 216596017588 Walker B; other site 216596017589 D-loop; other site 216596017590 H-loop/switch region; other site 216596017591 Pfam match to entry PF00005.11 ABC_tran 216596017592 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 216596017593 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 216596017594 inhibitor binding site; inhibition site 216596017595 active site 216596017596 Pfam match to entry PF04616.4 Glyco_hydro_43 216596017597 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 216596017598 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 216596017599 active site 216596017600 catalytic tetrad [active] 216596017601 Pfam match to entry PF00248.9 Aldo_ket_red 216596017602 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 216596017603 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 216596017604 Pfam match to entry PF01408.8 GFO_IDH_MocA 216596017605 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 216596017606 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 216596017607 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 216596017608 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 216596017609 Pfam match to entry PF00703.9 Glyco_hydro_2 216596017610 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 216596017611 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 216596017612 Walker A/P-loop; other site 216596017613 ATP binding site [chemical binding]; other site 216596017614 Q-loop/lid; other site 216596017615 ABC transporter signature motif; other site 216596017616 Walker B; other site 216596017617 D-loop; other site 216596017618 H-loop/switch region; other site 216596017619 TOBE domain; Region: TOBE_2; pfam08402 216596017620 Pfam match to entry PF00005.11 ABC_tran 216596017621 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216596017622 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596017623 dimer interface [polypeptide binding]; other site 216596017624 conserved gate region; other site 216596017625 putative PBP binding loops; other site 216596017626 ABC-ATPase subunit interface; other site 216596017627 Pfam match to entry PF00528.10 BPD_transp_1 216596017628 6 probable transmembrane helices predicted at aa 39-61, 113-135, 142-164, 179-198,219-241 and 282-304 216596017629 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 216596017630 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596017631 dimer interface [polypeptide binding]; other site 216596017632 conserved gate region; other site 216596017633 putative PBP binding loops; other site 216596017634 ABC-ATPase subunit interface; other site 216596017635 Pfam match to entry PF00528.10 BPD_transp_1 216596017636 6 probable transmembrane helices predicted at aa 21-43, 79-101, 114-133, 163-185,206-228 and 270-292 216596017637 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 216596017638 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 216596017639 Pfam match to entry PF01547.11 SBP_bac_1 216596017640 Transcriptional regulators [Transcription]; Region: PurR; COG1609 216596017641 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216596017642 DNA binding site [nucleotide binding] 216596017643 domain linker motif; other site 216596017644 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 216596017645 ligand binding site [chemical binding]; other site 216596017646 Pfam match to entry PF00532.8 Peripla_BP_1 216596017647 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 216596017648 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 216596017649 HIGH motif; other site 216596017650 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 216596017651 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 216596017652 active site 216596017653 KMSKS motif; other site 216596017654 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 216596017655 tRNA binding surface [nucleotide binding]; other site 216596017656 Pfam match to entry PF00133.8 tRNA-synt_1 216596017657 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596017658 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596017659 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 216596017660 putative dimerization interface [polypeptide binding]; other site 216596017661 Pfam match to entry PF03466.5 LysR_substrate 216596017662 Pfam match to entry PF00126.10 HTH_1 216596017663 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 216596017664 putative active site [active] 216596017665 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 216596017666 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 216596017667 ATP-grasp domain; Region: ATP-grasp_4; cl17255 216596017668 Pfam match to entry PF01820.9 Dala_Dala_lig_N 216596017669 Pfam match to entry PF07478.1 Dala_Dala_lig_C 216596017670 Predicted ATPase [General function prediction only]; Region: COG3911 216596017671 AAA domain; Region: AAA_28; pfam13521 216596017672 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596017673 S-adenosylmethionine binding site [chemical binding]; other site 216596017674 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 216596017675 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 216596017676 Pfam match to entry PF00583.9 Acetyltransf_1 216596017677 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216596017678 Coenzyme A binding pocket [chemical binding]; other site 216596017679 Pfam match to entry PF00583.9 Acetyltransf_1 216596017680 Predicted amidohydrolase [General function prediction only]; Region: COG0388 216596017681 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 216596017682 active site 216596017683 catalytic triad [active] 216596017684 dimer interface [polypeptide binding]; other site 216596017685 Pfam match to entry PF00795.10 CN_hydrolase 216596017686 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG0362 216596017687 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 216596017688 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 216596017689 Pfam match to entry PF00393.7 6PGD 216596017690 Pfam match to entry PF03446.3 NAD_binding_2 216596017691 Helix-turn-helix domain; Region: HTH_18; pfam12833 216596017692 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 216596017693 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216596017694 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 216596017695 Pfam match to entry PF00903.11 Glyoxalase 216596017696 PAS fold; Region: PAS_4; pfam08448 216596017697 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216596017698 putative active site [active] 216596017699 heme pocket [chemical binding]; other site 216596017700 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 216596017701 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 216596017702 putative acyl-acceptor binding pocket; other site 216596017703 Pfam match to entry PF03279.3 Lip_A_acyltrans 216596017704 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 216596017705 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH_like1; cd08266 216596017706 putative NAD(P) binding site [chemical binding]; other site 216596017707 structural Zn binding site [ion binding]; other site 216596017708 Pfam match to entry PF00107.10 ADH_zinc_N 216596017709 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06501 216596017710 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 216596017711 dimer interface [polypeptide binding]; other site 216596017712 active site 216596017713 Pfam match to entry PF02801.7 Ketoacyl-synt_C 216596017714 Pfam match to entry PF00109.11 ketoacyl-synt 216596017715 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06519 216596017716 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 216596017717 active site 216596017718 Pfam match to entry PF00109.11 ketoacyl-synt 216596017719 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases [Lipid metabolism]; Region: FabA; COG0764 216596017720 active site 2 [active] 216596017721 active site 1 [active] 216596017722 Pfam match to entry PF03061.8 4HBT 216596017723 acyl carrier protein; Provisional; Region: PRK06508 216596017724 Pfam match to entry PF00550.9 PP-binding 216596017725 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 216596017726 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 216596017727 ligand binding site [chemical binding]; other site 216596017728 flexible hinge region; other site 216596017729 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 216596017730 putative switch regulator; other site 216596017731 non-specific DNA interactions [nucleotide binding]; other site 216596017732 DNA binding site [nucleotide binding] 216596017733 sequence specific DNA binding site [nucleotide binding]; other site 216596017734 putative cAMP binding site [chemical binding]; other site 216596017735 Pfam match to entry PF00027.13 cNMP_binding 216596017736 Pfam match to entry PF00325.9 Crp 216596017737 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 216596017738 4 probable transmembrane helices predicted at aa 62-81, 83-105, 162-181 and 303-325 216596017739 Pfam match to entry PF03186.3 CobD_Cbib 216596017740 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 216596017741 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216596017742 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596017743 homodimer interface [polypeptide binding]; other site 216596017744 catalytic residue [active] 216596017745 Pfam match to entry PF00155.8 Aminotran_1_2 216596017746 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 216596017747 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 216596017748 Pfam match to entry PF01656.7 CbiA 216596017749 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 216596017750 active site 216596017751 SAM binding site [chemical binding]; other site 216596017752 homodimer interface [polypeptide binding]; other site 216596017753 Pfam match to entry PF00590.7 TP_methylase 216596017754 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 216596017755 active site 216596017756 Pfam match to entry PF01156.8 IU_nuc_hydro 216596017757 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 216596017758 Pfam match to entry PF01890.6 CbiG 216596017759 SnoaL-like domain; Region: SnoaL_2; pfam12680 216596017760 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 216596017761 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216596017762 non-specific DNA binding site [nucleotide binding]; other site 216596017763 salt bridge; other site 216596017764 sequence-specific DNA binding site [nucleotide binding]; other site 216596017765 Pfam match to entry PF01381.9 HTH_3 216596017766 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 216596017767 cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986 216596017768 Pfam match to entry PF02572.4 CobA_CobO_BtuR 216596017769 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 216596017770 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 216596017771 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 216596017772 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 216596017773 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 216596017774 Pfam match to entry PF02514.5 CobN-Mg_chel 216596017775 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 216596017776 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 216596017777 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 216596017778 Pfam match to entry PF02492.6 cobW 216596017779 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 216596017780 homotrimer interface [polypeptide binding]; other site 216596017781 Walker A motif; other site 216596017782 GTP binding site [chemical binding]; other site 216596017783 Walker B motif; other site 216596017784 Pfam match to entry PF02283.5 CobU 216596017785 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 216596017786 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 216596017787 Cl- selectivity filter; other site 216596017788 Cl- binding residues [ion binding]; other site 216596017789 pore gating glutamate residue; other site 216596017790 dimer interface [polypeptide binding]; other site 216596017791 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 216596017792 10 probable transmembrane helices predicted at aa 27-49, 77-96, 171-193, 203-225,246-268, 283-305, 318-340, 345-367, 374-396 and 406-428 216596017793 Pfam match to entry PF00654.9 Voltage_CLC 216596017794 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 216596017795 cyclase homology domain; Region: CHD; cd07302 216596017796 nucleotidyl binding site; other site 216596017797 metal binding site [ion binding]; metal-binding site 216596017798 dimer interface [polypeptide binding]; other site 216596017799 Pfam match to entry PF00211.9 Guanylate_cyc 216596017800 gluconate 5-dehydrogenase; Provisional; Region: PRK06124 216596017801 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216596017802 NAD(P) binding site [chemical binding]; other site 216596017803 active site 216596017804 Pfam match to entry PF00106.11 adh_short 216596017805 cobyric acid synthase; Provisional; Region: PRK00784 216596017806 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 216596017807 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 216596017808 catalytic triad [active] 216596017809 Pfam match to entry PF01656.7 CbiA 216596017810 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 216596017811 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 216596017812 Pfam match to entry PF04069.2 OpuAC 216596017813 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 216596017814 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596017815 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216596017816 dimerization interface [polypeptide binding]; other site 216596017817 Pfam match to entry PF03466.5 LysR_substrate 216596017818 Pfam match to entry PF00126.10 HTH_1 216596017819 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 216596017820 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 216596017821 Walker A/P-loop; other site 216596017822 ATP binding site [chemical binding]; other site 216596017823 Q-loop/lid; other site 216596017824 ABC transporter signature motif; other site 216596017825 Walker B; other site 216596017826 D-loop; other site 216596017827 H-loop/switch region; other site 216596017828 Pfam match to entry PF00005.11 ABC_tran 216596017829 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 216596017830 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 216596017831 Walker A/P-loop; other site 216596017832 ATP binding site [chemical binding]; other site 216596017833 Q-loop/lid; other site 216596017834 ABC transporter signature motif; other site 216596017835 Walker B; other site 216596017836 D-loop; other site 216596017837 H-loop/switch region; other site 216596017838 Pfam match to entry PF00005.11 ABC_tran 216596017839 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 216596017840 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596017841 TM-ABC transporter signature motif; other site 216596017842 8 probable transmembrane helices predicted at aa 10-32, 37-59, 79-101, 108-127,169-188, 218-240, 255-277 and 289-311 216596017843 Pfam match to entry PF02653.5 BPD_transp_2 216596017844 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596017845 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 216596017846 TM-ABC transporter signature motif; other site 216596017847 7 probable transmembrane helices predicted at aa 32-54, 82-104, 117-134, 165-187,218-240, 255-277 and 290-307 216596017848 Pfam match to entry PF02653.5 BPD_transp_2 216596017849 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 216596017850 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 216596017851 ligand binding site [chemical binding]; other site 216596017852 Pfam match to entry PF01094.13 ANF_receptor 216596017853 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 216596017854 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 216596017855 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 216596017856 shikimate binding site; other site 216596017857 NAD(P) binding site [chemical binding]; other site 216596017858 Pfam match to entry PF01488.5 Shikimate_DH 216596017859 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 216596017860 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 216596017861 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 216596017862 dimer interface [polypeptide binding]; other site 216596017863 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 216596017864 active site 216596017865 Fe binding site [ion binding]; other site 216596017866 Pfam match to entry PF00903.11 Glyoxalase 216596017867 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 216596017868 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 216596017869 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 216596017870 shikimate binding site; other site 216596017871 NAD(P) binding site [chemical binding]; other site 216596017872 Pfam match to entry PF01488.5 Shikimate_DH 216596017873 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596017874 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596017875 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 216596017876 putative dimerization interface [polypeptide binding]; other site 216596017877 Pfam match to entry PF03466.5 LysR_substrate 216596017878 Pfam match to entry PF00126.10 HTH_1 216596017879 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 216596017880 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 216596017881 active site 216596017882 Pfam match to entry PF04909.2 Amidohydro_2 216596017883 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 216596017884 Pfam match to entry PF04303.2 DUF453 216596017885 hypothetical protein; Provisional; Region: PRK09262 216596017886 Pfam match to entry PF03737.4 Methyltransf_6 216596017887 N-terminal, non-catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_N_like; cd09013 216596017888 tetramer interface [polypeptide binding]; other site 216596017889 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 216596017890 C-terminal, catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_C_like; cd09014 216596017891 tetramer interface [polypeptide binding]; other site 216596017892 active site 216596017893 metal binding site [ion binding]; metal-binding site 216596017894 Pfam match to entry PF00903.11 Glyoxalase 216596017895 Pfam match to entry PF00903.11 Glyoxalase 216596017896 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 216596017897 Pfam match to entry PF02585.4 DUF158 216596017898 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 216596017899 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 216596017900 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596017901 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596017902 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596017903 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596017904 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216596017905 dimerization interface [polypeptide binding]; other site 216596017906 Pfam match to entry PF00126.10 HTH_1 216596017907 Pfam match to entry PF00126.10 HTH_1 216596017908 Pfam match to entry PF03466.5 LysR_substrate 216596017909 Lysine efflux permease [General function prediction only]; Region: COG1279 216596017910 Pfam match to entry PF01810.7 LysE 216596017911 6 probable transmembrane helices predicted at aa 10-32, 41-60, 75-97, 117-139,149-171 and 183-200 216596017912 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 216596017913 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596017914 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216596017915 dimerization interface [polypeptide binding]; other site 216596017916 Pfam match to entry PF00126.10 HTH_1 216596017917 transcription elongation factor regulatory protein; Validated; Region: PRK06342 216596017918 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 216596017919 Pfam match to entry PF01272.7 GreA_GreB 216596017920 Protein of unknwon function (DUF3008); Region: DUF3008; pfam11450 216596017921 Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; pfam09939 216596017922 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 216596017923 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 216596017924 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 216596017925 high affinity sulphate transporter 1; Region: sulP; TIGR00815 216596017926 Sulfate transporter family; Region: Sulfate_transp; pfam00916 216596017927 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 216596017928 12 probable transmembrane helices predicted at aa 26-48, 53-75, 82-100, 105-127,139-161, 181-200, 212-234, 257-279, 292-314, 329-346,353-375 and 395-417 216596017929 Pfam match to entry PF00916.8 Sulfate_transp 216596017930 Pfam match to entry PF01740.8 STAS 216596017931 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 216596017932 Pfam match to entry PF03976.3 DUF344 216596017933 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 216596017934 putative active site [active] 216596017935 putative metal binding residues [ion binding]; other site 216596017936 signature motif; other site 216596017937 putative dimer interface [polypeptide binding]; other site 216596017938 putative phosphate binding site [ion binding]; other site 216596017939 Pfam match to entry PF01928.10 CYTH 216596017940 Protein of unknown function (DUF2955); Region: DUF2955; pfam11168 216596017941 10 probable transmembrane helices predicted at aa 19-41, 61-83, 90-107, 111-130,137-159, 186-208, 229-251, 256-275, 282-304 and 309-331 216596017942 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 216596017943 HlyD family secretion protein; Region: HlyD_3; pfam13437 216596017944 Pfam match to entry PF00529.8 HlyD 216596017945 Predicted integral membrane protein [Function unknown]; Region: COG5616 216596017946 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 216596017947 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216596017948 TPR motif; other site 216596017949 binding surface 216596017950 1 probable transmembrane helix predicted at aa 157-176 216596017951 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782 216596017952 Pfam match to entry PF05990.1 DUF900 216596017953 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 216596017954 Mechanosensitive ion channel; Region: MS_channel; pfam00924 216596017955 12 probable transmembrane helices predicted at aa 13-35, 129-151, 174-196, 206-228,255-274, 284-302, 322-339, 343-360, 386-408, 423-445,479-501 and 505-527 216596017956 Pfam match to entry PF00924.8 MS_channel 216596017957 2 probable transmembrane helices predicted at aa 4-26 and 87-109 216596017958 MarC family integral membrane protein; Region: MarC; cl00919 216596017959 Pfam match to entry PF01914.6 MarC 216596017960 6 probable transmembrane helices predicted at aa 9-31, 46-68, 73-95, 115-137,144-166 and 186-208 216596017961 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 216596017962 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 216596017963 conserved cys residue [active] 216596017964 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216596017965 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216596017966 1 probable transmembrane helix predicted at aa 21-39 216596017967 Pfam match to entry PF01965.9 DJ-1_PfpI 216596017968 Pfam match to entry PF00165.8 HTH_AraC 216596017969 Pfam match to entry PF00165.8 HTH_AraC 216596017970 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 216596017971 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596017972 active site 216596017973 phosphorylation site [posttranslational modification] 216596017974 intermolecular recognition site; other site 216596017975 dimerization interface [polypeptide binding]; other site 216596017976 Response regulator receiver domain; Region: Response_reg; pfam00072 216596017977 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596017978 active site 216596017979 phosphorylation site [posttranslational modification] 216596017980 intermolecular recognition site; other site 216596017981 dimerization interface [polypeptide binding]; other site 216596017982 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216596017983 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 216596017984 metal binding site [ion binding]; metal-binding site 216596017985 active site 216596017986 I-site; other site 216596017987 Pfam match to entry PF00990.8 GGDEF 216596017988 Pfam match to entry PF00072.9 Response_reg 216596017989 Pfam match to entry PF00072.9 Response_reg 216596017990 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 216596017991 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 216596017992 active site 216596017993 phosphorylation site [posttranslational modification] 216596017994 intermolecular recognition site; other site 216596017995 dimerization interface [polypeptide binding]; other site 216596017996 Response regulator receiver domain; Region: Response_reg; pfam00072 216596017997 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596017998 active site 216596017999 phosphorylation site [posttranslational modification] 216596018000 intermolecular recognition site; other site 216596018001 dimerization interface [polypeptide binding]; other site 216596018002 Pfam match to entry PF00072.9 Response_reg 216596018003 Low molecular weight phosphatase family; Region: LMWPc; cd00115 216596018004 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 216596018005 active site 216596018006 Pfam match to entry PF01451.6 LMWPc 216596018007 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 216596018008 Pfam match to entry PF00583.9 Acetyltransf_1 216596018009 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 216596018010 amphipathic channel; other site 216596018011 Asn-Pro-Ala signature motifs; other site 216596018012 Pfam match to entry PF00230.7 MIP 216596018013 6 probable transmembrane helices predicted at aa 12-33, 48-70, 91-113, 128-147,160-182 and 197-219 216596018014 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 216596018015 ArsC family; Region: ArsC; pfam03960 216596018016 catalytic residues [active] 216596018017 Pfam match to entry PF03960.4 ArsC 216596018018 arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690 216596018019 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 216596018020 Pfam match to entry PF03358.3 FMN_red 216596018021 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216596018022 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596018023 putative substrate translocation pore; other site 216596018024 12 probable transmembrane helices predicted at aa 13-35, 48-70, 77-99, 104-126,138-160, 165-187, 219-241, 245-267, 280-302, 312-334,346-368 and 372-391 216596018025 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 216596018026 Mechanosensitive ion channel; Region: MS_channel; pfam00924 216596018027 Pfam match to entry PF00924.8 MS_channel 216596018028 11 probable transmembrane helices predicted at aa 221-243, 264-286, 296-318,339-361, 371-393, 413-435, 439-461, 495-517, 537-559,589-611 and 621-643 216596018029 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 216596018030 Pfam match to entry PF06041.1 DUF924 216596018031 Response regulator receiver domain; Region: Response_reg; pfam00072 216596018032 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596018033 active site 216596018034 phosphorylation site [posttranslational modification] 216596018035 intermolecular recognition site; other site 216596018036 dimerization interface [polypeptide binding]; other site 216596018037 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 216596018038 Histidine kinase; Region: HisKA_2; pfam07568 216596018039 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596018040 ATP binding site [chemical binding]; other site 216596018041 Mg2+ binding site [ion binding]; other site 216596018042 G-X-G motif; other site 216596018043 Pfam match to entry PF02518.9 HATPase_c 216596018044 Pfam match to entry PF07568.1 HisKA_2 216596018045 Pfam match to entry PF00072.9 Response_reg 216596018046 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596018047 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216596018048 putative substrate translocation pore; other site 216596018049 13 probable transmembrane helices predicted at aa 71-93, 108-130, 137-159, 163-185,198-220, 224-246, 259-276, 286-308, 317-339, 349-371,392-414, 460-482 and 495-514 216596018050 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 216596018051 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 216596018052 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 216596018053 Pfam match to entry PF01547.11 SBP_bac_1 216596018054 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 216596018055 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596018056 dimer interface [polypeptide binding]; other site 216596018057 conserved gate region; other site 216596018058 putative PBP binding loops; other site 216596018059 ABC-ATPase subunit interface; other site 216596018060 6 probable transmembrane helices predicted at aa 76-98, 140-162, 169-191, 228-250,271-293 and 331-353 216596018061 Pfam match to entry PF00528.10 BPD_transp_1 216596018062 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216596018063 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596018064 dimer interface [polypeptide binding]; other site 216596018065 conserved gate region; other site 216596018066 putative PBP binding loops; other site 216596018067 ABC-ATPase subunit interface; other site 216596018068 6 probable transmembrane helices predicted at aa 20-42, 115-137, 149-171, 181-203,228-250 and 283-302 216596018069 Pfam match to entry PF00528.10 BPD_transp_1 216596018070 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 216596018071 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 216596018072 Walker A/P-loop; other site 216596018073 ATP binding site [chemical binding]; other site 216596018074 Q-loop/lid; other site 216596018075 ABC transporter signature motif; other site 216596018076 Walker B; other site 216596018077 D-loop; other site 216596018078 H-loop/switch region; other site 216596018079 TOBE domain; Region: TOBE_2; pfam08402 216596018080 Pfam match to entry PF00005.11 ABC_tran 216596018081 Pfam match to entry PF03459.4 TOBE 216596018082 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 216596018083 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216596018084 Walker A/P-loop; other site 216596018085 ATP binding site [chemical binding]; other site 216596018086 Q-loop/lid; other site 216596018087 ABC transporter signature motif; other site 216596018088 Walker B; other site 216596018089 D-loop; other site 216596018090 H-loop/switch region; other site 216596018091 TOBE domain; Region: TOBE_2; pfam08402 216596018092 Pfam match to entry PF00005.11 ABC_tran 216596018093 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 216596018094 dihydroxyacetone kinase, ATP-dependent; Region: dak_ATP; TIGR02361 216596018095 DAK2 domain; Region: Dak2; pfam02734 216596018096 Pfam match to entry PF02733.5 Dak1 216596018097 Pfam match to entry PF02734.5 Dak2 216596018098 DAK2 domain; Region: Dak2; cl03685 216596018099 Pfam match to entry PF02734.5 Dak2 216596018100 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 216596018101 active site 216596018102 active pocket/dimerization site; other site 216596018103 phosphorylation site [posttranslational modification] 216596018104 Pfam match to entry PF03610.4 EIIA-man 216596018105 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 216596018106 dimerization domain swap beta strand [polypeptide binding]; other site 216596018107 regulatory protein interface [polypeptide binding]; other site 216596018108 active site 216596018109 regulatory phosphorylation site [posttranslational modification]; other site 216596018110 Pfam match to entry PF00381.8 PTS-HPr 216596018111 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 216596018112 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 216596018113 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 216596018114 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 216596018115 Pfam match to entry PF05524.1 PEP-utilisers_N 216596018116 Pfam match to entry PF00391.9 PEP-utilizers 216596018117 Pfam match to entry PF02896.6 PEP-utilizers_C 216596018118 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 216596018119 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 216596018120 Pfam match to entry PF02733.5 Dak1 216596018121 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 216596018122 Acetyl esterase (deacetylase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3458 216596018123 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 216596018124 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 216596018125 Pfam match to entry PF02525.5 Flavodoxin_2 216596018126 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216596018127 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216596018128 Pfam match to entry PF00440.8 TetR_N 216596018129 Epoxide hydrolase N terminus; Region: EHN; pfam06441 216596018130 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 216596018131 Pfam match to entry PF06441.1 EHN 216596018132 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216596018133 Transcriptional regulators [Transcription]; Region: GntR; COG1802 216596018134 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596018135 DNA-binding site [nucleotide binding]; DNA binding site 216596018136 FCD domain; Region: FCD; pfam07729 216596018137 Pfam match to entry PF00392.9 GntR 216596018138 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 216596018139 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596018140 S-adenosylmethionine binding site [chemical binding]; other site 216596018141 Pfam match to entry PF01596.7 Methyltransf_3 216596018142 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 216596018143 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 216596018144 FAD binding pocket [chemical binding]; other site 216596018145 FAD binding motif [chemical binding]; other site 216596018146 phosphate binding motif [ion binding]; other site 216596018147 NAD binding pocket [chemical binding]; other site 216596018148 Pfam match to entry PF04954.2 SIP 216596018149 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 216596018150 Pfam match to entry PF01266.8 DAO 216596018151 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 216596018152 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 216596018153 catalytic triad [active] 216596018154 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 216596018155 homotrimer interaction site [polypeptide binding]; other site 216596018156 putative active site [active] 216596018157 Pfam match to entry PF01042.8 Ribonuc_L-PSP 216596018158 Pfam match to entry PF00117.10 GATase 216596018159 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596018160 ABC-ATPase subunit interface; other site 216596018161 putative PBP binding loops; other site 216596018162 Pfam match to entry PF00528.10 BPD_transp_1 216596018163 5 probable transmembrane helices predicted at aa 24-46, 58-80, 85-107, 136-158 and 188-210 216596018164 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 216596018165 Pfam match to entry PF00528.10 BPD_transp_1 216596018166 5 probable transmembrane helices predicted at aa 20-42, 61-83, 88-110, 122-144 and 182-204 216596018167 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 216596018168 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 216596018169 Walker A/P-loop; other site 216596018170 ATP binding site [chemical binding]; other site 216596018171 Q-loop/lid; other site 216596018172 ABC transporter signature motif; other site 216596018173 Walker B; other site 216596018174 D-loop; other site 216596018175 H-loop/switch region; other site 216596018176 Pfam match to entry PF00005.11 ABC_tran 216596018177 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 216596018178 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 216596018179 substrate binding pocket [chemical binding]; other site 216596018180 membrane-bound complex binding site; other site 216596018181 hinge residues; other site 216596018182 Pfam match to entry PF00497.8 SBP_bac_3 216596018183 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 216596018184 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 216596018185 conserved cys residue [active] 216596018186 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216596018187 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216596018188 Pfam match to entry PF01965.9 DJ-1_PfpI 216596018189 1 probable transmembrane helix predicted at aa 135-157 216596018190 Pfam match to entry PF00165.8 HTH_AraC 216596018191 Pfam match to entry PF00165.8 HTH_AraC 216596018192 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 216596018193 MarR family; Region: MarR; pfam01047 216596018194 Pfam match to entry PF01047.8 MarR 216596018195 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 216596018196 active site 216596018197 8-oxo-dGMP binding site [chemical binding]; other site 216596018198 nudix motif; other site 216596018199 metal binding site [ion binding]; metal-binding site 216596018200 Pfam match to entry PF00293.12 NUDIX 216596018201 Protein of unknown function (DUF3095); Region: DUF3095; pfam11294 216596018202 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 216596018203 Pfam match to entry PF02566.5 OsmC 216596018204 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596018205 S-adenosylmethionine binding site [chemical binding]; other site 216596018206 CAP-Gly domain; Region: CAP_GLY; cl08315 216596018207 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921 216596018208 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 216596018209 Pfam match to entry PF06904.1 Extensin-like_C 216596018210 Cache domain; Region: Cache_2; pfam08269 216596018211 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216596018212 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 216596018213 dimer interface [polypeptide binding]; other site 216596018214 putative CheW interface [polypeptide binding]; other site 216596018215 Pfam match to entry PF00015.9 MCPsignal 216596018216 Pfam match to entry PF00672.10 HAMP 216596018217 2 probable transmembrane helices predicted at aa 10-32 and 187-209 216596018218 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 216596018219 Pfam match to entry PF03061.8 4HBT 216596018220 6 probable transmembrane helices predicted at aa 15-37, 44-65, 75-97, 118-136,149-166 and 171-193 216596018221 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 216596018222 Pfam match to entry PF07394.2 DUF1501 216596018223 1 probable transmembrane helix predicted at aa 13-35 216596018224 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 216596018225 FlxA-like protein; Region: FlxA; pfam14282 216596018226 Protein of unknown function, DUF486; Region: DUF486; cl01236 216596018227 Pfam match to entry PF04342.2 DUF486 216596018228 4 probable transmembrane helices predicted at aa 7-29, 33-55, 76-90 and 94-113 216596018229 RDD family; Region: RDD; pfam06271 216596018230 Pfam match to entry PF06271.1 RDD 216596018231 4 probable transmembrane helices predicted at aa 33-55, 145-167, 204-226 and 246-268 216596018232 putative sialic acid transporter; Region: 2A0112; TIGR00891 216596018233 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596018234 putative substrate translocation pore; other site 216596018235 Pfam match to entry PF00083.9 Sugar_tr 216596018236 8 probable transmembrane helices predicted at aa 21-43, 53-75, 88-110, 153-186,210-232, 252-274, 286-308 and 372-394 216596018237 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596018238 S-adenosylmethionine binding site [chemical binding]; other site 216596018239 Cupin; Region: Cupin_6; pfam12852 216596018240 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216596018241 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216596018242 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216596018243 Pfam match to entry PF00165.8 HTH_AraC 216596018244 Pfam match to entry PF00165.8 HTH_AraC 216596018245 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 216596018246 classical (c) SDRs; Region: SDR_c; cd05233 216596018247 NAD(P) binding site [chemical binding]; other site 216596018248 active site 216596018249 Pfam match to entry PF00106.11 adh_short 216596018250 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 216596018251 NmrA-like family; Region: NmrA; pfam05368 216596018252 NADP binding site [chemical binding]; other site 216596018253 active site 216596018254 regulatory binding site [polypeptide binding]; other site 216596018255 Pfam match to entry PF05368.1 NmrA 216596018256 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596018257 LysR family transcriptional regulator; Provisional; Region: PRK14997 216596018258 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 216596018259 putative effector binding pocket; other site 216596018260 dimerization interface [polypeptide binding]; other site 216596018261 Pfam match to entry PF00126.10 HTH_1 216596018262 Pfam match to entry PF03466.5 LysR_substrate 216596018263 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 216596018264 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 216596018265 Sulfate transporter family; Region: Sulfate_transp; pfam00916 216596018266 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 216596018267 Pfam match to entry PF01740.8 STAS 216596018268 Pfam match to entry PF00916.8 Sulfate_transp 216596018269 12 probable transmembrane helices predicted at aa 19-41, 45-62, 67-84, 89-111,124-141, 145-167, 174-196, 216-238, 259-281, 291-309,316-338 and 353-375 216596018270 Response regulator receiver domain; Region: Response_reg; pfam00072 216596018271 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 216596018272 active site 216596018273 phosphorylation site [posttranslational modification] 216596018274 intermolecular recognition site; other site 216596018275 dimerization interface [polypeptide binding]; other site 216596018276 Pfam match to entry PF00072.9 Response_reg 216596018277 Putative catalytic domain, repeat 1, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_1; cd09172 216596018278 PLD-like domain; Region: PLDc_2; pfam13091 216596018279 putative active site [active] 216596018280 catalytic site [active] 216596018281 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 216596018282 PLD-like domain; Region: PLDc_2; pfam13091 216596018283 putative active site [active] 216596018284 catalytic site [active] 216596018285 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 216596018286 Pfam match to entry PF05988.1 DUF899 216596018287 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 216596018288 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 216596018289 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 216596018290 1 probable transmembrane helix predicted at aa 4-26 216596018291 Pfam match to entry PF00023.12 Ank 216596018292 Pfam match to entry PF00023.12 Ank 216596018293 Pfam match to entry PF00023.12 Ank 216596018294 Pfam match to entry PF00023.12 Ank 216596018295 Pfam match to entry PF00023.12 Ank 216596018296 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 216596018297 Pfam match to entry PF04945.2 YHS 216596018298 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 216596018299 cyclase homology domain; Region: CHD; cd07302 216596018300 nucleotidyl binding site; other site 216596018301 metal binding site [ion binding]; metal-binding site 216596018302 dimer interface [polypeptide binding]; other site 216596018303 Predicted integral membrane protein [Function unknown]; Region: COG5616 216596018304 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 216596018305 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216596018306 TPR motif; other site 216596018307 binding surface 216596018308 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216596018309 binding surface 216596018310 TPR motif; other site 216596018311 Pfam match to entry PF00515.11 TPR 216596018312 Pfam match to entry PF00515.11 TPR 216596018313 Pfam match to entry PF00515.11 TPR 216596018314 1 probable transmembrane helix predicted at aa 190-212 216596018315 Pfam match to entry PF00211.9 Guanylate_cyc 216596018316 Rhomboid family; Region: Rhomboid; pfam01694 216596018317 9 probable transmembrane helices predicted at aa 20-37, 47-66, 203-225, 263-285,290-312, 316-338, 351-368, 378-397 and 406-428 216596018318 Pfam match to entry PF01694.8 Rhomboid 216596018319 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 216596018320 cyclase homology domain; Region: CHD; cd07302 216596018321 nucleotidyl binding site; other site 216596018322 metal binding site [ion binding]; metal-binding site 216596018323 dimer interface [polypeptide binding]; other site 216596018324 Pfam match to entry PF00211.9 Guanylate_cyc 216596018325 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 216596018326 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 216596018327 Pfam match to entry PF00723.9 Glyco_hydro_15 216596018328 excinuclease ABC subunit B; Provisional; Region: PRK05298 216596018329 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 216596018330 ATP binding site [chemical binding]; other site 216596018331 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216596018332 nucleotide binding region [chemical binding]; other site 216596018333 ATP-binding site [chemical binding]; other site 216596018334 Ultra-violet resistance protein B; Region: UvrB; pfam12344 216596018335 UvrB/uvrC motif; Region: UVR; pfam02151 216596018336 Pfam match to entry PF04851.3 ResIII 216596018337 Pfam match to entry PF00271.13 Helicase_C 216596018338 Pfam match to entry PF02151.6 UVR 216596018339 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216596018340 Coenzyme A binding pocket [chemical binding]; other site 216596018341 Pfam match to entry PF00583.9 Acetyltransf_1 216596018342 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 216596018343 Ca2+ binding site [ion binding]; other site 216596018344 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 216596018345 Ca2+ binding site [ion binding]; other site 216596018346 Pfam match to entry PF00353.8 HemolysinCabind 216596018347 Pfam match to entry PF00353.8 HemolysinCabind 216596018348 Pfam match to entry PF00353.8 HemolysinCabind 216596018349 Pfam match to entry PF00353.8 HemolysinCabind 216596018350 Pfam match to entry PF00353.8 HemolysinCabind 216596018351 Pfam match to entry PF00353.8 HemolysinCabind 216596018352 Pfam match to entry PF00353.8 HemolysinCabind 216596018353 Pfam match to entry PF00353.8 HemolysinCabind 216596018354 Pfam match to entry PF00353.8 HemolysinCabind 216596018355 Pfam match to entry PF00353.8 HemolysinCabind 216596018356 Pfam match to entry PF00353.8 HemolysinCabind 216596018357 Pfam match to entry PF00028.7 Cadherin 216596018358 Pfam match to entry PF00028.7 Cadherin 216596018359 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 216596018360 Pfam match to entry PF03992.3 ABM 216596018361 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 216596018362 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 216596018363 DNA-binding site [nucleotide binding]; DNA binding site 216596018364 RNA-binding motif; other site 216596018365 Pfam match to entry PF00313.8 CSD 216596018366 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 216596018367 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 216596018368 FMN binding site [chemical binding]; other site 216596018369 active site 216596018370 catalytic residues [active] 216596018371 substrate binding site [chemical binding]; other site 216596018372 Pfam match to entry PF01207.7 Dus 216596018373 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 216596018374 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 216596018375 protein binding site [polypeptide binding]; other site 216596018376 Pfam match to entry PF00595.8 PDZ 216596018377 Pfam match to entry PF00089.9 Trypsin 216596018378 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 216596018379 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 216596018380 Pfam match to entry PF00561.8 Abhydrolase_1 216596018381 1 probable transmembrane helix predicted at aa 74-93 216596018382 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 216596018383 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 216596018384 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216596018385 dimer interface [polypeptide binding]; other site 216596018386 phosphorylation site [posttranslational modification] 216596018387 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596018388 ATP binding site [chemical binding]; other site 216596018389 Mg2+ binding site [ion binding]; other site 216596018390 G-X-G motif; other site 216596018391 Pfam match to entry PF02518.9 HATPase_c 216596018392 Pfam match to entry PF00512.10 HisKA 216596018393 Pfam match to entry PF00672.10 HAMP 216596018394 2 probable transmembrane helices predicted at aa 20-42 and 162-184 216596018395 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 216596018396 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596018397 active site 216596018398 phosphorylation site [posttranslational modification] 216596018399 intermolecular recognition site; other site 216596018400 dimerization interface [polypeptide binding]; other site 216596018401 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216596018402 DNA binding site [nucleotide binding] 216596018403 Pfam match to entry PF00486.11 Trans_reg_C 216596018404 Pfam match to entry PF00072.9 Response_reg 216596018405 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 216596018406 Predicted flavoprotein [General function prediction only]; Region: COG0431 216596018407 Pfam match to entry PF03358.3 FMN_red 216596018408 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 216596018409 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216596018410 Walker A/P-loop; other site 216596018411 ATP binding site [chemical binding]; other site 216596018412 Q-loop/lid; other site 216596018413 ABC transporter signature motif; other site 216596018414 Walker B; other site 216596018415 D-loop; other site 216596018416 H-loop/switch region; other site 216596018417 Pfam match to entry PF00005.11 ABC_tran 216596018418 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 216596018419 Pfam match to entry PF06182.1 DUF990 216596018420 4 probable transmembrane helices predicted at aa 114-136, 151-173, 180-199 and 232-254 216596018421 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 216596018422 6 probable transmembrane helices predicted at aa 42-64, 79-98, 129-151, 166-188,209-231 and 246-268 216596018423 Pfam match to entry PF06182.1 DUF990 216596018424 Predicted transcriptional regulators [Transcription]; Region: COG1733 216596018425 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 216596018426 Pfam match to entry PF01638.6 DUF24 216596018427 RibD C-terminal domain; Region: RibD_C; cl17279 216596018428 Pfam match to entry PF01872.7 RibD_C 216596018429 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216596018430 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216596018431 Pfam match to entry PF00440.8 TetR_N 216596018432 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 216596018433 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596018434 S-adenosylmethionine binding site [chemical binding]; other site 216596018435 Pfam match to entry PF01596.7 Methyltransf_3 216596018436 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216596018437 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216596018438 Pfam match to entry PF00440.8 TetR_N 216596018439 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 216596018440 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 216596018441 active site 216596018442 catalytic tetrad [active] 216596018443 Pfam match to entry PF00248.9 Aldo_ket_red 216596018444 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216596018445 Coenzyme A binding pocket [chemical binding]; other site 216596018446 Pfam match to entry PF00583.9 Acetyltransf_1 216596018447 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 216596018448 2 probable transmembrane helices predicted at aa 50-72 and 85-107 216596018449 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 216596018450 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216596018451 putative DNA binding site [nucleotide binding]; other site 216596018452 putative Zn2+ binding site [ion binding]; other site 216596018453 AsnC family; Region: AsnC_trans_reg; pfam01037 216596018454 Pfam match to entry PF01037.8 AsnC_trans_reg 216596018455 argininosuccinate synthase; Provisional; Region: PRK13820 216596018456 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 216596018457 ANP binding site [chemical binding]; other site 216596018458 Substrate Binding Site II [chemical binding]; other site 216596018459 Substrate Binding Site I [chemical binding]; other site 216596018460 Pfam match to entry PF00764.7 Arginosuc_synth 216596018461 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 216596018462 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12870 216596018463 UbiA prenyltransferase family; Region: UbiA; pfam01040 216596018464 7 probable transmembrane helices predicted at aa 39-58, 107-129, 136-157, 177-199,220-242, 246-268 and 281-303 216596018465 Pfam match to entry PF01040.7 UbiA 216596018466 Signal peptide predicted for RL2991 by SignalP 2.0 HMM (Signal peptide probabilty 0.951) with cleavage site probability 0.537 between residues 30 and 31 216596018467 Predicted periplasmic protein [Function unknown]; Region: COG3698 216596018468 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 216596018469 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 216596018470 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 216596018471 putative C-terminal domain interface [polypeptide binding]; other site 216596018472 putative GSH binding site (G-site) [chemical binding]; other site 216596018473 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 216596018474 putative dimer interface [polypeptide binding]; other site 216596018475 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 216596018476 dimer interface [polypeptide binding]; other site 216596018477 N-terminal domain interface [polypeptide binding]; other site 216596018478 putative substrate binding pocket (H-site) [chemical binding]; other site 216596018479 Pfam match to entry PF00043.11 GST_C 216596018480 Pfam match to entry PF02798.6 GST_N 216596018481 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 216596018482 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 216596018483 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216596018484 Walker A/P-loop; other site 216596018485 ATP binding site [chemical binding]; other site 216596018486 Q-loop/lid; other site 216596018487 ABC transporter signature motif; other site 216596018488 Walker B; other site 216596018489 D-loop; other site 216596018490 H-loop/switch region; other site 216596018491 Pfam match to entry PF00005.11 ABC_tran 216596018492 Pfam match to entry PF00664.9 ABC_membrane 216596018493 5 probable transmembrane helices predicted at aa 33-55, 60-82, 89-111, 176-198 and 276-298 216596018494 Uncharacterized conserved protein [Function unknown]; Region: COG3791 216596018495 Pfam match to entry PF04828.3 DUF636 216596018496 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 216596018497 dimer interface [polypeptide binding]; other site 216596018498 Pfam match to entry PF06983.1 3-dmu-9_3-mt 216596018499 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 216596018500 catalytic core [active] 216596018501 Pfam match to entry PF00300.9 PGAM 216596018502 Predicted amidohydrolase [General function prediction only]; Region: COG0388 216596018503 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 216596018504 active site 216596018505 catalytic triad [active] 216596018506 dimer interface [polypeptide binding]; other site 216596018507 Pfam match to entry PF00795.10 CN_hydrolase 216596018508 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216596018509 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 216596018510 active site 216596018511 metal binding site [ion binding]; metal-binding site 216596018512 Pfam match to entry PF00903.11 Glyoxalase 216596018513 2 probable transmembrane helices predicted at aa 15-35 and 48-70 216596018514 dihydrodipicolinate reductase; Provisional; Region: PRK00048 216596018515 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 216596018516 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 216596018517 Pfam match to entry PF01113.9 DapB_N 216596018518 Pfam match to entry PF05173.2 DapB_C 216596018519 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 216596018520 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 216596018521 Pfam match to entry PF02423.5 OCD_Mu_crystall 216596018522 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 216596018523 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216596018524 Coenzyme A binding pocket [chemical binding]; other site 216596018525 Pfam match to entry PF00583.9 Acetyltransf_1 216596018526 Pfam match to entry PF04886.2 PT 216596018527 Pfam match to entry PF04886.2 PT 216596018528 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 216596018529 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216596018530 catalytic residue [active] 216596018531 Pfam match to entry PF00282.7 Pyridoxal_deC 216596018532 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG4551 216596018533 active site 216596018534 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216596018535 Coenzyme A binding pocket [chemical binding]; other site 216596018536 Pfam match to entry PF00583.9 Acetyltransf_1 216596018537 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596018538 S-adenosylmethionine binding site [chemical binding]; other site 216596018539 TIGR02594 family protein; Region: TIGR02594 216596018540 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596018541 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216596018542 putative substrate translocation pore; other site 216596018543 12 probable transmembrane helices predicted at aa 7-24, 39-61, 68-87, 91-113,134-153, 157-179, 192-214, 229-251, 264-286, 290-312,325-347 and 352-374 216596018544 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 216596018545 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 216596018546 active site 216596018547 HIGH motif; other site 216596018548 dimer interface [polypeptide binding]; other site 216596018549 KMSKS motif; other site 216596018550 Pfam match to entry PF01479.9 S4 216596018551 Pfam match to entry PF00579.11 tRNA-synt_1b 216596018552 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 216596018553 12 probable transmembrane helices predicted at aa 17-39, 59-81, 106-128, 143-165,172-194, 209-231, 255-277, 297-319, 340-362, 372-391,398-420 and 430-449 216596018554 Pfam match to entry PF02705.5 K_trans 216596018555 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 216596018556 Pfam match to entry PF00999.9 Na_H_Exchanger 216596018557 13 probable transmembrane helices predicted at aa 5-24, 31-53, 57-76, 83-105,110-132, 153-175, 185-207, 214-231, 235-252, 265-287,302-324, 345-367 and 382-404 216596018558 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 216596018559 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 216596018560 putative active site [active] 216596018561 1 probable transmembrane helix predicted at aa 5-24 216596018562 Pfam match to entry PF00775.10 Dioxygenase_C 216596018563 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 216596018564 bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they...; Region: bact_SO_family_Moco; cd02108 216596018565 Moco binding site; other site 216596018566 metal coordination site [ion binding]; other site 216596018567 Pfam match to entry PF00174.8 Oxidored_molyb 216596018568 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 216596018569 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 216596018570 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 216596018571 Pfam match to entry PF01292.9 Ni_hydr_CYTB 216596018572 4 probable transmembrane helices predicted at aa 21-43, 124-146, 194-216 and 239-261 216596018573 1 probable transmembrane helix predicted at aa 4-26 216596018574 RNA polymerase sigma factor; Provisional; Region: PRK12536 216596018575 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216596018576 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 216596018577 DNA binding residues [nucleotide binding] 216596018578 Pfam match to entry PF04542.2 Sigma70_r2 216596018579 Protein of unknown function (DUF1109); Region: DUF1109; pfam06532 216596018580 Pfam match to entry PF06532.1 DUF1109 216596018581 6 probable transmembrane helices predicted at aa 26-48, 58-80, 92-113, 128-150,157-179 and 189-211 216596018582 bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603 216596018583 Right handed beta helix region; Region: Beta_helix; pfam13229 216596018584 Right handed beta helix region; Region: Beta_helix; pfam13229 216596018585 Right handed beta helix region; Region: Beta_helix; pfam13229 216596018586 EamA-like transporter family; Region: EamA; pfam00892 216596018587 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 216596018588 EamA-like transporter family; Region: EamA; pfam00892 216596018589 10 probable transmembrane helices predicted at aa 13-35, 50-72, 85-104, 109-131,138-155, 170-188, 195-217, 232-251, 258-280 and 290-307 216596018590 Pfam match to entry PF00892.8 DUF6 216596018591 Pfam match to entry PF00892.8 DUF6 216596018592 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 216596018593 FtsX-like permease family; Region: FtsX; pfam02687 216596018594 Pfam match to entry PF02687.7 FtsX 216596018595 4 probable transmembrane helices predicted at aa 23-45, 263-285, 317-339 and 364-386 216596018596 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 216596018597 FtsX-like permease family; Region: FtsX; pfam02687 216596018598 Pfam match to entry PF02687.7 FtsX 216596018599 4 probable transmembrane helices predicted at aa 20-42, 259-281, 302-324 and 344-366 216596018600 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 216596018601 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 216596018602 Walker A/P-loop; other site 216596018603 ATP binding site [chemical binding]; other site 216596018604 Q-loop/lid; other site 216596018605 ABC transporter signature motif; other site 216596018606 Walker B; other site 216596018607 D-loop; other site 216596018608 H-loop/switch region; other site 216596018609 Pfam match to entry PF00005.11 ABC_tran 216596018610 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 216596018611 HlyD family secretion protein; Region: HlyD_3; pfam13437 216596018612 Helix-turn-helix domain; Region: HTH_18; pfam12833 216596018613 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216596018614 Pfam match to entry PF00165.8 HTH_AraC 216596018615 Pfam match to entry PF00165.8 HTH_AraC 216596018616 7 probable transmembrane helices predicted at aa 13-35, 45-67, 72-91, 106-122,129-150, 165-187 and 200-219 216596018617 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 216596018618 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 216596018619 putative NAD(P) binding site [chemical binding]; other site 216596018620 active site 216596018621 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 216596018622 active site 216596018623 Dienelactone hydrolase family; Region: DLH; pfam01738 216596018624 oxygenase, pseudogene; N-terminus is similar to the N-terminus of Rhizobium loti (Mesorhizobium loti) probable oxygenase. UniProt:Q98JA5_RHILO (EMBL:BA000012) (521 aa). Frameshift mutation after codon 91; similarity:fasta; with=UniProt:Q98JA5_RHILO (EMBL:BA000012); Rhizobium loti (Mesorhizobium loti).; Probable oxygenase.; length=521; id 70.312; 128 aa overlap; query 8-129; subject 9-135 216596018625 tyramine oxidase; Provisional; Region: tynA; PRK11504 216596018626 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 216596018627 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 216596018628 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 216596018629 Pfam match to entry PF01179.8 Cu_amine_oxid 216596018630 Pfam match to entry PF02728.4 Cu_amine_oxidN3 216596018631 Pfam match to entry PF02727.4 Cu_amine_oxidN2 216596018632 1 probable transmembrane helix predicted at aa 13-35 216596018633 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 216596018634 Pfam match to entry PF00324.10 AA_permease 216596018635 12 probable transmembrane helices predicted at aa 73-95, 105-127, 139-161, 181-203,215-237, 252-274, 295-317, 352-374, 395-417, 430-452,459-481 and 496-518 216596018636 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 216596018637 Helix-turn-helix domain; Region: HTH_18; pfam12833 216596018638 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 216596018639 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 216596018640 Predicted small integral membrane protein [Function unknown]; Region: COG5605 216596018641 3 probable transmembrane helices predicted at aa 26-48, 52-74 and 81-103 216596018642 Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_1; cd02864 216596018643 Subunit I/III interface [polypeptide binding]; other site 216596018644 Pfam match to entry PF00510.8 COX3 216596018645 5 probable transmembrane helices predicted at aa 43-65, 80-102, 123-145, 168-190 and 221-240 216596018646 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 216596018647 Subunit I/III interface [polypeptide binding]; other site 216596018648 Pfam match to entry PF00510.8 COX3 216596018649 6 probable transmembrane helices predicted at aa 4-21, 55-77, 92-109, 122-141,161-183 and 204-226 216596018650 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 216596018651 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 216596018652 12 probable transmembrane helices predicted at aa 41-63, 83-105, 126-148, 174-196,216-238, 273-295, 307-329, 344-366, 379-401, 416-438,451-473 and 498-520 216596018653 Pfam match to entry PF00115.8 COX1 216596018654 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 216596018655 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 216596018656 Pfam match to entry PF00116.8 COX2 216596018657 3 probable transmembrane helices predicted at aa 3-25, 40-62 and 83-105 216596018658 Cytochrome c2 [Energy production and conversion]; Region: COG3474 216596018659 Pfam match to entry PF00034.8 Cytochrom_C 216596018660 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 216596018661 5 probable transmembrane helices predicted at aa 7-28, 43-65, 72-94, 156-178 and 191-213 216596018662 Pfam match to entry PF01810.7 LysE 216596018663 Uncharacterized protein family (UPF0160); Region: UPF0160; pfam03690 216596018664 Pfam match to entry PF03690.3 UPF0160 216596018665 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 216596018666 nucleotide binding site/active site [active] 216596018667 HIT family signature motif; other site 216596018668 catalytic residue [active] 216596018669 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 216596018670 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 216596018671 Walker A/P-loop; other site 216596018672 ATP binding site [chemical binding]; other site 216596018673 Q-loop/lid; other site 216596018674 ABC transporter signature motif; other site 216596018675 Walker B; other site 216596018676 D-loop; other site 216596018677 H-loop/switch region; other site 216596018678 Pfam match to entry PF00005.11 ABC_tran 216596018679 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 216596018680 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 216596018681 ABC-ATPase subunit interface; other site 216596018682 dimer interface [polypeptide binding]; other site 216596018683 putative PBP binding regions; other site 216596018684 10 probable transmembrane helices predicted at aa 7-29, 73-95, 102-124, 129-151,158-180, 200-222, 235-257, 261-283, 290-312 and 317-339 216596018685 Pfam match to entry PF01032.7 FecCD 216596018686 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 216596018687 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 216596018688 putative ligand binding residues [chemical binding]; other site 216596018689 Pfam match to entry PF01497.7 Peripla_BP_2 216596018690 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 216596018691 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 216596018692 putative active site [active] 216596018693 Pfam match to entry PF01850.8 PIN 216596018694 Putative phosphatase (DUF442); Region: DUF442; cl17385 216596018695 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 216596018696 Pfam match to entry PF00753.12 Lactamase_B 216596018697 Pfam match to entry PF04273.2 DUF442 216596018698 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 216596018699 Pfam match to entry PF02635.5 DrsE 216596018700 Cupin; Region: Cupin_6; pfam12852 216596018701 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 216596018702 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216596018703 Pfam match to entry PF00165.8 HTH_AraC 216596018704 Pfam match to entry PF00165.8 HTH_AraC 216596018705 Uncharacterized conserved protein [Function unknown]; Region: COG5361 216596018706 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 216596018707 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 216596018708 Pfam match to entry PF06863.1 DUF1254 216596018709 Pfam match to entry PF06742.1 DUF1214 216596018710 Cupin domain; Region: Cupin_2; pfam07883 216596018711 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 216596018712 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216596018713 Pfam match to entry PF00903.11 Glyoxalase 216596018714 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 216596018715 Bacterial transcriptional activator domain; Region: BTAD; smart01043 216596018716 Predicted integral membrane protein [Function unknown]; Region: COG5616 216596018717 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216596018718 TPR motif; other site 216596018719 binding surface 216596018720 Pfam match to entry PF03704.4 BTAD 216596018721 AAA domain; Region: AAA_33; pfam13671 216596018722 AAA domain; Region: AAA_17; pfam13207 216596018723 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 216596018724 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 216596018725 active site 216596018726 catalytic tetrad [active] 216596018727 Pfam match to entry PF00248.9 Aldo_ket_red 216596018728 1 probable transmembrane helix predicted at aa 27-49 216596018729 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 216596018730 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596018731 active site 216596018732 phosphorylation site [posttranslational modification] 216596018733 intermolecular recognition site; other site 216596018734 dimerization interface [polypeptide binding]; other site 216596018735 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216596018736 DNA binding site [nucleotide binding] 216596018737 Pfam match to entry PF00072.9 Response_reg 216596018738 Pfam match to entry PF00486.11 Trans_reg_C 216596018739 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 216596018740 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596018741 ATP binding site [chemical binding]; other site 216596018742 Mg2+ binding site [ion binding]; other site 216596018743 G-X-G motif; other site 216596018744 2 probable transmembrane helices predicted at aa 15-37 and 171-193 216596018745 Pfam match to entry PF00672.10 HAMP 216596018746 Pfam match to entry PF02518.9 HATPase_c 216596018747 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 216596018748 3 probable transmembrane helices predicted at aa 16-33, 43-65 and 72-94 216596018749 4 probable transmembrane helices predicted at aa 13-35, 78-100, 107-129 and 158-177 216596018750 cell division protein FtsZ; Validated; Region: PRK09330 216596018751 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 216596018752 nucleotide binding site [chemical binding]; other site 216596018753 SulA interaction site; other site 216596018754 Pfam match to entry PF00091.13 Tubulin 216596018755 Pfam match to entry PF03953.5 Tubulin_C 216596018756 VCBS repeat; Region: VCBS_repeat; TIGR01965 216596018757 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216596018758 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 216596018759 salt bridge; other site 216596018760 non-specific DNA binding site [nucleotide binding]; other site 216596018761 sequence-specific DNA binding site [nucleotide binding]; other site 216596018762 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 216596018763 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 216596018764 putative NAD(P) binding site [chemical binding]; other site 216596018765 3 probable transmembrane helices predicted at aa 4-23, 43-65 and 70-92 216596018766 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 216596018767 putative hydrophobic ligand binding site [chemical binding]; other site 216596018768 Pfam match to entry PF05146.3 DUF704 216596018769 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 216596018770 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216596018771 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216596018772 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 216596018773 Pfam match to entry PF00440.8 TetR_N 216596018774 Domain of unknown function (DUF4168); Region: DUF4168; pfam13767 216596018775 1 probable transmembrane helix predicted at aa 5-27 216596018776 L-ectoine synthase; Reviewed; Region: ectC; PRK13290 216596018777 Pfam match to entry PF06339.1 Ectoine_synth 216596018778 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 216596018779 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596018780 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216596018781 dimerization interface [polypeptide binding]; other site 216596018782 Pfam match to entry PF00126.10 HTH_1 216596018783 Pfam match to entry PF03466.5 LysR_substrate 216596018784 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 216596018785 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216596018786 metal binding site [ion binding]; metal-binding site 216596018787 active site 216596018788 I-site; other site 216596018789 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216596018790 Pfam match to entry PF00990.8 GGDEF 216596018791 Pfam match to entry PF00563.9 EAL 216596018792 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 216596018793 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596018794 S-adenosylmethionine binding site [chemical binding]; other site 216596018795 Cache domain; Region: Cache_1; pfam02743 216596018796 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 216596018797 dimerization interface [polypeptide binding]; other site 216596018798 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 216596018799 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 216596018800 2 probable transmembrane helices predicted at aa 20-42 and 432-454 216596018801 Pfam match to entry PF02743.5 Cache 216596018802 Pfam match to entry PF00672.10 HAMP 216596018803 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5381 216596018804 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 216596018805 Pfam match to entry PF02518.9 HATPase_c 216596018806 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 216596018807 anti sigma factor interaction site; other site 216596018808 regulatory phosphorylation site [posttranslational modification]; other site 216596018809 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 216596018810 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 216596018811 dimerization interface [polypeptide binding]; other site 216596018812 putative DNA binding site [nucleotide binding]; other site 216596018813 putative Zn2+ binding site [ion binding]; other site 216596018814 AsnC family; Region: AsnC_trans_reg; pfam01037 216596018815 Pfam match to entry PF01037.8 AsnC_trans_reg 216596018816 ornithine cyclodeaminase; Validated; Region: PRK07589 216596018817 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 216596018818 Pfam match to entry PF02423.5 OCD_Mu_crystall 216596018819 conserved hypothetical protein, pseudogene; Frameshift mutation after codon 89. Stop signal after codon 175. It is possible that the following open reading frame could be transcribed as a separate coding sequence rather than be part of the pseudogene.; similarity:fasta; with=UniProt:Q8XSJ0_RALSO (EMBL:AL646078); Ralstonia solanacearum (Pseudomonas solanacearum).; Hypothetical protein RSp0484. Hypothetical protein RSp0484.; length=319; id 63.487; 304 aa overlap; query 8-308; subject 16-319 216596018820 1 probable transmembrane helix predicted at aa 10-32 216596018821 1 probable transmembrane helix predicted at aa 87-109 216596018822 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 216596018823 1 probable transmembrane helix predicted at aa 5-27 216596018824 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 216596018825 3 probable transmembrane helices predicted at aa 79-101, 108-130 and 150-172 216596018826 Predicted transcriptional regulators [Transcription]; Region: COG1695 216596018827 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 216596018828 Pfam match to entry PF03551.4 PadR 216596018829 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 216596018830 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 216596018831 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 216596018832 active site 216596018833 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 216596018834 catalytic tetrad [active] 216596018835 Pfam match to entry PF00248.9 Aldo_ket_red 216596018836 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 216596018837 Pfam match to entry PF00753.12 Lactamase_B 216596018838 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596018839 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596018840 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 216596018841 putative effector binding pocket; other site 216596018842 putative dimerization interface [polypeptide binding]; other site 216596018843 Pfam match to entry PF00126.10 HTH_1 216596018844 Pfam match to entry PF03466.5 LysR_substrate 216596018845 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 216596018846 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 216596018847 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 216596018848 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 216596018849 Pfam match to entry PF02449.5 Glyco_hydro_42 216596018850 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 216596018851 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 216596018852 Walker A/P-loop; other site 216596018853 ATP binding site [chemical binding]; other site 216596018854 Q-loop/lid; other site 216596018855 ABC transporter signature motif; other site 216596018856 Walker B; other site 216596018857 D-loop; other site 216596018858 H-loop/switch region; other site 216596018859 TOBE domain; Region: TOBE_2; pfam08402 216596018860 Pfam match to entry PF00005.11 ABC_tran 216596018861 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216596018862 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596018863 dimer interface [polypeptide binding]; other site 216596018864 conserved gate region; other site 216596018865 putative PBP binding loops; other site 216596018866 ABC-ATPase subunit interface; other site 216596018867 Pfam match to entry PF00528.10 BPD_transp_1 216596018868 6 probable transmembrane helices predicted at aa 16-38, 81-103, 110-132, 147-169,190-212 and 246-268 216596018869 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 216596018870 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596018871 dimer interface [polypeptide binding]; other site 216596018872 conserved gate region; other site 216596018873 putative PBP binding loops; other site 216596018874 ABC-ATPase subunit interface; other site 216596018875 Pfam match to entry PF00528.10 BPD_transp_1 216596018876 7 probable transmembrane helices predicted at aa 26-48, 53-75, 90-112, 124-146,174-196, 217-239 and 277-299 216596018877 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 216596018878 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 216596018879 Pfam match to entry PF01547.11 SBP_bac_1 216596018880 1 probable transmembrane helix predicted at aa 13-35 216596018881 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 216596018882 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 216596018883 nucleotide binding site [chemical binding]; other site 216596018884 Pfam match to entry PF00480.8 ROK 216596018885 Cupin domain; Region: Cupin_2; pfam07883 216596018886 Cupin domain; Region: Cupin_2; cl17218 216596018887 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 216596018888 Phosphotransferase enzyme family; Region: APH; pfam01636 216596018889 active site 216596018890 substrate binding site [chemical binding]; other site 216596018891 ATP binding site [chemical binding]; other site 216596018892 Pfam match to entry PF01636.8 APH 216596018893 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 216596018894 active site 216596018895 catalytic site [active] 216596018896 substrate binding site [chemical binding]; other site 216596018897 Pfam match to entry PF00929.11 Exonuc_X-T 216596018898 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 216596018899 10 probable transmembrane helices predicted at aa 7-29, 34-56, 69-88, 93-115,122-144, 148-167, 179-198, 208-230, 237-259 and 264-286 216596018900 Pfam match to entry PF00892.8 DUF6 216596018901 Pfam match to entry PF00892.8 DUF6 216596018902 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 216596018903 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596018904 DNA-binding site [nucleotide binding]; DNA binding site 216596018905 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216596018906 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596018907 homodimer interface [polypeptide binding]; other site 216596018908 catalytic residue [active] 216596018909 Pfam match to entry PF00392.9 GntR 216596018910 Pfam match to entry PF00155.8 Aminotran_1_2 216596018911 Response regulator receiver domain; Region: Response_reg; pfam00072 216596018912 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596018913 active site 216596018914 phosphorylation site [posttranslational modification] 216596018915 intermolecular recognition site; other site 216596018916 dimerization interface [polypeptide binding]; other site 216596018917 Pfam match to entry PF00072.9 Response_reg 216596018918 CHASE4 domain; Region: CHASE4; pfam05228 216596018919 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 216596018920 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216596018921 dimer interface [polypeptide binding]; other site 216596018922 phosphorylation site [posttranslational modification] 216596018923 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596018924 ATP binding site [chemical binding]; other site 216596018925 Mg2+ binding site [ion binding]; other site 216596018926 G-X-G motif; other site 216596018927 Pfam match to entry PF02518.9 HATPase_c 216596018928 Pfam match to entry PF00512.10 HisKA 216596018929 1 probable transmembrane helix predicted at aa 238-257 216596018930 Pfam match to entry PF05228.1 CHASE4 216596018931 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 216596018932 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216596018933 Coenzyme A binding pocket [chemical binding]; other site 216596018934 Pfam match to entry PF00583.9 Acetyltransf_1 216596018935 glutathionine S-transferase; Provisional; Region: PRK10542 216596018936 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 216596018937 C-terminal domain interface [polypeptide binding]; other site 216596018938 GSH binding site (G-site) [chemical binding]; other site 216596018939 dimer interface [polypeptide binding]; other site 216596018940 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 216596018941 dimer interface [polypeptide binding]; other site 216596018942 N-terminal domain interface [polypeptide binding]; other site 216596018943 substrate binding pocket (H-site) [chemical binding]; other site 216596018944 Pfam match to entry PF02798.6 GST_N 216596018945 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 216596018946 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 216596018947 TAP-like protein; Region: Abhydrolase_4; pfam08386 216596018948 Pfam match to entry PF00561.8 Abhydrolase_1 216596018949 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 216596018950 active site 216596018951 Pfam match to entry PF02126.7 PTE 216596018952 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 216596018953 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 216596018954 Pfam match to entry PF05988.1 DUF899 216596018955 2 probable transmembrane helices predicted at aa 67-89 and 99-121 216596018956 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 216596018957 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 216596018958 active site 216596018959 metal binding site [ion binding]; metal-binding site 216596018960 Pfam match to entry PF00149.12 Metallophos 216596018961 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 216596018962 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 216596018963 active site 216596018964 Pfam match to entry PF00459.10 Inositol_P 216596018965 Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566 216596018966 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 216596018967 putative active site [active] 216596018968 catalytic site [active] 216596018969 putative metal binding site [ion binding]; other site 216596018970 oligomer interface [polypeptide binding]; other site 216596018971 Pfam match to entry PF03009.6 GDPD 216596018972 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 216596018973 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216596018974 Walker A/P-loop; other site 216596018975 ATP binding site [chemical binding]; other site 216596018976 Q-loop/lid; other site 216596018977 ABC transporter signature motif; other site 216596018978 Walker B; other site 216596018979 D-loop; other site 216596018980 H-loop/switch region; other site 216596018981 Pfam match to entry PF00005.11 ABC_tran 216596018982 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216596018983 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596018984 dimer interface [polypeptide binding]; other site 216596018985 conserved gate region; other site 216596018986 putative PBP binding loops; other site 216596018987 ABC-ATPase subunit interface; other site 216596018988 Pfam match to entry PF00528.10 BPD_transp_1 216596018989 6 probable transmembrane helices predicted at aa 7-29, 75-97, 104-126, 168-190,210-232 and 271-293 216596018990 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 216596018991 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596018992 dimer interface [polypeptide binding]; other site 216596018993 conserved gate region; other site 216596018994 putative PBP binding loops; other site 216596018995 ABC-ATPase subunit interface; other site 216596018996 Pfam match to entry PF00528.10 BPD_transp_1 216596018997 6 probable transmembrane helices predicted at aa 12-34, 75-97, 117-139, 159-181,229-251 and 266-288 216596018998 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 216596018999 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 216596019000 Pfam match to entry PF01547.11 SBP_bac_1 216596019001 Transcriptional regulators [Transcription]; Region: MarR; COG1846 216596019002 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216596019003 putative DNA binding site [nucleotide binding]; other site 216596019004 putative Zn2+ binding site [ion binding]; other site 216596019005 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 216596019006 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 216596019007 Pfam match to entry PF00480.8 ROK 216596019008 replicative DNA helicase; Provisional; Region: PRK05973 216596019009 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 216596019010 Pfam match to entry PF03796.3 DnaB_C 216596019011 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 216596019012 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596019013 S-adenosylmethionine binding site [chemical binding]; other site 216596019014 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 216596019015 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 216596019016 Pfam match to entry PF00296.10 Bac_luciferase 216596019017 Ion channel; Region: Ion_trans_2; pfam07885 216596019018 4 probable transmembrane helices predicted at aa 4-26, 46-68, 83-102 and 114-136 216596019019 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 216596019020 Pfam match to entry PF01594.6 UPF0118 216596019021 9 probable transmembrane helices predicted at aa 15-34, 41-60, 70-92, 155-174,178-200, 221-243, 248-270, 275-297 and 317-348 216596019022 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 216596019023 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216596019024 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216596019025 Pfam match to entry PF00165.8 HTH_AraC 216596019026 Pfam match to entry PF00165.8 HTH_AraC 216596019027 Pfam match to entry PF02311.7 AraC_binding 216596019028 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 216596019029 Pfam match to entry PF05721.2 PhyH 216596019030 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596019031 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596019032 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 216596019033 putative effector binding pocket; other site 216596019034 dimerization interface [polypeptide binding]; other site 216596019035 Pfam match to entry PF00126.10 HTH_1 216596019036 Pfam match to entry PF03466.5 LysR_substrate 216596019037 H+ Antiporter protein; Region: 2A0121; TIGR00900 216596019038 9 probable transmembrane helices predicted at aa 26-48, 80-102, 167-189, 221-243,258-280, 287-304, 314-336, 348-370 and 375-397 216596019039 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216596019040 dimerization interface [polypeptide binding]; other site 216596019041 putative DNA binding site [nucleotide binding]; other site 216596019042 putative Zn2+ binding site [ion binding]; other site 216596019043 Pfam match to entry PF01022.8 HTH_5 216596019044 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 216596019045 cyclase homology domain; Region: CHD; cd07302 216596019046 nucleotidyl binding site; other site 216596019047 metal binding site [ion binding]; metal-binding site 216596019048 dimer interface [polypeptide binding]; other site 216596019049 Pfam match to entry PF00211.9 Guanylate_cyc 216596019050 Similar to N-terminus to codon 110 of Rhizobium sp. (strain NGR234) adenylate cyclase (ec 4.6.1.1). UniProt:Q6W1V7_RHISN (EMBL:AY316747) (354 aa). This CDS may form part of a pseudogene with RL1349 or may be transcribed as a separate gene; similarity:fasta; with=UniProt:Q6W1V7_RHISN (EMBL:AY316747); Rhizobium sp. (strain NGR234).; Adenylate cyclase (EC 4.6.1.1).; length=354; id 74.312; 109 aa overlap; query 1-109; subject 1-109 216596019051 Signal peptide predicted for RL3151 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.969 between residues 26 and 27 216596019052 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 216596019053 putative hydrophobic ligand binding site [chemical binding]; other site 216596019054 Pfam match to entry PF05146.3 DUF704 216596019055 riboflavin synthase subunit beta; Provisional; Region: PRK12419 216596019056 active site 216596019057 homopentamer interface [polypeptide binding]; other site 216596019058 Pfam match to entry PF00885.7 DMRL_synthase 216596019059 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 216596019060 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216596019061 Pfam match to entry PF00903.11 Glyoxalase 216596019062 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 216596019063 Pfam match to entry PF01292.9 Ni_hydr_CYTB 216596019064 4 probable transmembrane helices predicted at aa 9-31, 46-68, 89-111 and 142-164 216596019065 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 216596019066 MarR family; Region: MarR_2; pfam12802 216596019067 Pfam match to entry PF01047.8 MarR 216596019068 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 216596019069 Pfam match to entry PF03992.3 ABM 216596019070 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 216596019071 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596019072 The C-terminal substrate-domain of LysR-type transcriptional regulators for beta-lactamase genes, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_beta_lactamase; cd08484 216596019073 putative dimerization interface [polypeptide binding]; other site 216596019074 putative substrate binding pocket [chemical binding]; other site 216596019075 Pfam match to entry PF03466.5 LysR_substrate 216596019076 Pfam match to entry PF00126.10 HTH_1 216596019077 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 216596019078 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 216596019079 Pfam match to entry PF00144.9 Beta-lactamase 216596019080 Protein of unknown function (DUF1194); Region: DUF1194; pfam06707 216596019081 Pfam match to entry PF06707.1 DUF1194 216596019082 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596019083 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596019084 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 216596019085 putative effector binding pocket; other site 216596019086 dimerization interface [polypeptide binding]; other site 216596019087 Pfam match to entry PF03466.5 LysR_substrate 216596019088 Pfam match to entry PF00126.10 HTH_1 216596019089 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216596019090 NAD(P) binding site [chemical binding]; other site 216596019091 Pfam match to entry PF00106.11 adh_short 216596019092 classical (c) SDRs; Region: SDR_c; cd05233 216596019093 Pfam match to entry PF00106.11 adh_short 216596019094 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 216596019095 homotrimer interaction site [polypeptide binding]; other site 216596019096 putative active site [active] 216596019097 Pfam match to entry PF01042.8 Ribonuc_L-PSP 216596019098 FecR protein; Region: FecR; pfam04773 216596019099 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 216596019100 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216596019101 TPR motif; other site 216596019102 binding surface 216596019103 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216596019104 binding surface 216596019105 TPR motif; other site 216596019106 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 216596019107 binding surface 216596019108 TPR motif; other site 216596019109 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 216596019110 Pfam match to entry PF00515.11 TPR 216596019111 Pfam match to entry PF00515.11 TPR 216596019112 Pfam match to entry PF00515.11 TPR 216596019113 Pfam match to entry PF00515.11 TPR 216596019114 Pfam match to entry PF00593.9 TonB_dep_Rec 216596019115 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 216596019116 CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080 216596019117 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 216596019118 cyclase homology domain; Region: CHD; cd07302 216596019119 nucleotidyl binding site; other site 216596019120 metal binding site [ion binding]; metal-binding site 216596019121 dimer interface [polypeptide binding]; other site 216596019122 3 probable transmembrane helices predicted at aa 20-42, 314-336 and 343-365 216596019123 Pfam match to entry PF05226.1 CHASE2 216596019124 Pfam match to entry PF00211.9 Guanylate_cyc 216596019125 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 216596019126 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 216596019127 Pfam match to entry PF00583.9 Acetyltransf_1 216596019128 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 216596019129 active site 216596019130 NTP binding site [chemical binding]; other site 216596019131 metal binding triad [ion binding]; metal-binding site 216596019132 antibiotic binding site [chemical binding]; other site 216596019133 Pfam match to entry PF01909.9 NTP_transf_2 216596019134 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 216596019135 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 216596019136 Pfam match to entry PF01557.8 FAA_hydrolase 216596019137 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 216596019138 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 216596019139 trimer interface [polypeptide binding]; other site 216596019140 putative metal binding site [ion binding]; other site 216596019141 Pfam match to entry PF00132.9 Hexapep 216596019142 Pfam match to entry PF00132.9 Hexapep 216596019143 Pfam match to entry PF00132.9 Hexapep 216596019144 Pfam match to entry PF00132.9 Hexapep 216596019145 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 216596019146 Pfam match to entry PF04140.3 ICMT 216596019147 5 probable transmembrane helices predicted at aa 20-42, 47-69, 89-108, 123-145 and 181-203 216596019148 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 216596019149 Pfam match to entry PF07366.1 DUF1486 216596019150 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 216596019151 metal binding site 2 [ion binding]; metal-binding site 216596019152 putative DNA binding helix; other site 216596019153 metal binding site 1 [ion binding]; metal-binding site 216596019154 dimer interface [polypeptide binding]; other site 216596019155 structural Zn2+ binding site [ion binding]; other site 216596019156 Pfam match to entry PF01475.6 FUR 216596019157 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 216596019158 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 216596019159 ABC-ATPase subunit interface; other site 216596019160 dimer interface [polypeptide binding]; other site 216596019161 putative PBP binding regions; other site 216596019162 Pfam match to entry PF00950.7 ABC-3 216596019163 7 probable transmembrane helices predicted at aa 31-53, 78-100, 112-134, 154-176,197-219, 239-261 and 268-285 216596019164 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 216596019165 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 216596019166 Pfam match to entry PF00005.11 ABC_tran 216596019167 Signal peptide predicted for RL3178 by SignalP 2.0 HMM (Signal peptide probabilty 0.952) with cleavage site probability 0.326 between residues 25 and 26 216596019168 1 probable transmembrane helix predicted at aa 12-34 216596019169 ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531 216596019170 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 216596019171 metal binding site [ion binding]; metal-binding site 216596019172 Pfam match to entry PF01297.7 SBP_bac_9 216596019173 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 216596019174 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 216596019175 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 216596019176 Pfam match to entry PF02492.6 cobW 216596019177 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 216596019178 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 216596019179 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216596019180 active site 216596019181 Pfam match to entry PF00903.11 Glyoxalase 216596019182 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 216596019183 Domain of unknown function DUF21; Region: DUF21; pfam01595 216596019184 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 216596019185 Transporter associated domain; Region: CorC_HlyC; smart01091 216596019186 4 probable transmembrane helices predicted at aa 31-53, 87-109, 129-151 and 172-194 216596019187 Pfam match to entry PF01595.7 DUF21 216596019188 Pfam match to entry PF00571.13 CBS 216596019189 Pfam match to entry PF00571.13 CBS 216596019190 Pfam match to entry PF03471.5 CorC_HlyC 216596019191 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 216596019192 Chromate transporter; Region: Chromate_transp; pfam02417 216596019193 11 probable transmembrane helices predicted at aa 119-141, 146-168, 180-197,201-218, 256-278, 288-310, 331-353, 363-385, 406-428,443-465 and 470-489 216596019194 Pfam match to entry PF02417.5 Chromate_transp 216596019195 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 216596019196 active site residue [active] 216596019197 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 216596019198 1 probable transmembrane helix predicted at aa 75-97 216596019199 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 216596019200 Pfam match to entry PF02567.5 PhzC-PhzF 216596019201 NUDIX domain; Region: NUDIX; pfam00293 216596019202 nudix motif; other site 216596019203 Pfam match to entry PF00293.12 NUDIX 216596019204 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 216596019205 putative metal binding site [ion binding]; other site 216596019206 Pfam match to entry PF03372.6 Exo_endo_phos 216596019207 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 216596019208 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 216596019209 Walker A/P-loop; other site 216596019210 ATP binding site [chemical binding]; other site 216596019211 Q-loop/lid; other site 216596019212 ABC transporter signature motif; other site 216596019213 Walker B; other site 216596019214 D-loop; other site 216596019215 H-loop/switch region; other site 216596019216 TOBE domain; Region: TOBE_2; pfam08402 216596019217 Pfam match to entry PF00005.11 ABC_tran 216596019218 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 216596019219 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596019220 dimer interface [polypeptide binding]; other site 216596019221 conserved gate region; other site 216596019222 putative PBP binding loops; other site 216596019223 ABC-ATPase subunit interface; other site 216596019224 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596019225 dimer interface [polypeptide binding]; other site 216596019226 conserved gate region; other site 216596019227 putative PBP binding loops; other site 216596019228 ABC-ATPase subunit interface; other site 216596019229 Pfam match to entry PF00528.10 BPD_transp_1 216596019230 14 probable transmembrane helices predicted at aa 13-35, 65-87, 94-116, 141-163,188-210, 215-237, 250-267, 301-323, 356-378, 393-415,422-444, 473-495, 502-519 and 529-551 216596019231 Pfam match to entry PF00528.10 BPD_transp_1 216596019232 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 216596019233 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 216596019234 Pfam match to entry PF01547.11 SBP_bac_1 216596019235 1 probable transmembrane helix predicted at aa 46-68 216596019236 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216596019237 Transcriptional regulators [Transcription]; Region: MarR; COG1846 216596019238 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 216596019239 Pfam match to entry PF01047.8 MarR 216596019240 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 216596019241 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 216596019242 active site 216596019243 catalytic tetrad [active] 216596019244 Pfam match to entry PF00248.9 Aldo_ket_red 216596019245 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 216596019246 Lamin Tail Domain; Region: LTD; pfam00932 216596019247 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 216596019248 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216596019249 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596019250 homodimer interface [polypeptide binding]; other site 216596019251 catalytic residue [active] 216596019252 Pfam match to entry PF00155.8 Aminotran_1_2 216596019253 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 216596019254 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 216596019255 homodimer interface [polypeptide binding]; other site 216596019256 substrate-cofactor binding pocket; other site 216596019257 catalytic residue [active] 216596019258 Pfam match to entry PF01063.7 Aminotran_4 216596019259 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 216596019260 putative active site [active] 216596019261 Pfam match to entry PF01850.8 PIN 216596019262 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 216596019263 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 216596019264 Pfam match to entry PF05016.2 Plasmid_stabil 216596019265 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 216596019266 Methyltransferase domain; Region: Methyltransf_23; pfam13489 216596019267 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596019268 S-adenosylmethionine binding site [chemical binding]; other site 216596019269 ketol-acid reductoisomerase; Provisional; Region: PRK05479 216596019270 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 216596019271 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 216596019272 Pfam match to entry PF01450.8 IlvC 216596019273 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216596019274 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216596019275 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 216596019276 Pfam match to entry PF00440.8 TetR_N 216596019277 Protein of unknown function (DUF4087); Region: DUF4087; pfam13316 216596019278 9 probable transmembrane helices predicted at aa 25-47, 103-125, 138-160, 183-205,226-248, 263-294, 307-329, 333-355 and 362-384 216596019279 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 216596019280 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 216596019281 Ligand binding site; other site 216596019282 Putative Catalytic site; other site 216596019283 DXD motif; other site 216596019284 2 probable transmembrane helices predicted at aa 236-258 and 268-290 216596019285 Pfam match to entry PF00535.10 Glycos_transf_2 216596019286 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 216596019287 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 216596019288 Pfam match to entry PF00165.8 HTH_AraC 216596019289 Pfam match to entry PF00165.8 HTH_AraC 216596019290 Pfam match to entry PF06719.1 AraC_N 216596019291 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 216596019292 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 216596019293 putative NAD(P) binding site [chemical binding]; other site 216596019294 putative substrate binding site [chemical binding]; other site 216596019295 catalytic Zn binding site [ion binding]; other site 216596019296 structural Zn binding site [ion binding]; other site 216596019297 dimer interface [polypeptide binding]; other site 216596019298 Pfam match to entry PF00107.10 ADH_zinc_N 216596019299 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 216596019300 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 216596019301 G1 box; other site 216596019302 GTP/Mg2+ binding site [chemical binding]; other site 216596019303 G2 box; other site 216596019304 Switch I region; other site 216596019305 G3 box; other site 216596019306 Switch II region; other site 216596019307 G4 box; other site 216596019308 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 216596019309 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 216596019310 Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to the...; Region: Elongation_Factor_C; cl02785 216596019311 Pfam match to entry PF00679.10 EFG_C 216596019312 Pfam match to entry PF03764.4 EFG_IV 216596019313 Pfam match to entry PF03144.8 GTP_EFTU_D2 216596019314 Pfam match to entry PF00009.10 GTP_EFTU 216596019315 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 216596019316 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 216596019317 1 probable transmembrane helix predicted at aa 369-386 216596019318 Pfam match to entry PF00070.12 Pyr_redox 216596019319 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 216596019320 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216596019321 putative DNA binding site [nucleotide binding]; other site 216596019322 putative Zn2+ binding site [ion binding]; other site 216596019323 AsnC family; Region: AsnC_trans_reg; pfam01037 216596019324 Pfam match to entry PF01037.8 AsnC_trans_reg 216596019325 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 216596019326 aspartate racemase; Region: asp_race; TIGR00035 216596019327 Pfam match to entry PF01177.8 Asp_Glu_race 216596019328 MarR family; Region: MarR_2; pfam12802 216596019329 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 216596019330 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216596019331 Coenzyme A binding pocket [chemical binding]; other site 216596019332 Pfam match to entry PF01047.8 MarR 216596019333 Pfam match to entry PF00583.9 Acetyltransf_1 216596019334 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216596019335 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216596019336 Pfam match to entry PF00440.8 TetR_N 216596019337 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 216596019338 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596019339 12 probable transmembrane helices predicted at aa 16-38, 53-75, 87-104, 109-131,143-162, 172-194, 225-247, 257-279, 286-305, 310-332,349-371 and 375-397 216596019340 Predicted transcriptional regulators [Transcription]; Region: COG1733 216596019341 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 216596019342 Pfam match to entry PF01638.6 DUF24 216596019343 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 216596019344 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 216596019345 NADP binding site [chemical binding]; other site 216596019346 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 216596019347 active site 216596019348 hydrophilic channel; other site 216596019349 dimerization interface [polypeptide binding]; other site 216596019350 catalytic residues [active] 216596019351 active site lid [active] 216596019352 Pfam match to entry PF03740.3 PdxJ 216596019353 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 216596019354 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 216596019355 dimer interface [polypeptide binding]; other site 216596019356 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 216596019357 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216596019358 DNA binding residues [nucleotide binding] 216596019359 dimerization interface [polypeptide binding]; other site 216596019360 Pfam match to entry PF00376.9 MerR 216596019361 Pfam match to entry PF00196.8 GerE 216596019362 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 216596019363 AAA domain; Region: AAA_30; pfam13604 216596019364 Family description; Region: UvrD_C_2; pfam13538 216596019365 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596019366 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596019367 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 216596019368 putative effector binding pocket; other site 216596019369 dimerization interface [polypeptide binding]; other site 216596019370 Pfam match to entry PF03466.5 LysR_substrate 216596019371 Pfam match to entry PF00126.10 HTH_1 216596019372 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 216596019373 Uncharacterized conserved protein [Function unknown]; Region: COG2128 216596019374 Pfam match to entry PF02627.6 CMD 216596019375 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216596019376 NADH(P)-binding; Region: NAD_binding_10; pfam13460 216596019377 NAD(P) binding site [chemical binding]; other site 216596019378 active site 216596019379 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 216596019380 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 216596019381 Mechanosensitive ion channel; Region: MS_channel; pfam00924 216596019382 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 216596019383 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 216596019384 ligand binding site [chemical binding]; other site 216596019385 flexible hinge region; other site 216596019386 5 probable transmembrane helices predicted at aa 5-27, 37-56, 80-98, 113-135 and 142-164 216596019387 Pfam match to entry PF00924.8 MS_channel 216596019388 Pfam match to entry PF00027.13 cNMP_binding 216596019389 Predicted transcriptional regulator [Transcription]; Region: COG1959 216596019390 Transcriptional regulator; Region: Rrf2; pfam02082 216596019391 Pfam match to entry PF02082.5 Rrf2 216596019392 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 216596019393 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216596019394 putative Zn2+ binding site [ion binding]; other site 216596019395 putative DNA binding site [nucleotide binding]; other site 216596019396 Pfam match to entry PF01047.8 MarR 216596019397 Cupin domain; Region: Cupin_2; pfam07883 216596019398 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 216596019399 Pfam match to entry PF00903.11 Glyoxalase 216596019400 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 216596019401 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 216596019402 Pfam match to entry PF03640.4 Lipoprotein_15 216596019403 Pfam match to entry PF03640.4 Lipoprotein_15 216596019404 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 216596019405 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216596019406 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 216596019407 DNA binding residues [nucleotide binding] 216596019408 Pfam match to entry PF04542.2 Sigma70_r2 216596019409 Pfam match to entry PF04545.3 Sigma70_r4 216596019410 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 216596019411 1 probable transmembrane helix predicted at aa 84-106 216596019412 nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889 216596019413 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 216596019414 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 216596019415 Pfam match to entry PF02211.5 NHase_beta 216596019416 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 216596019417 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 216596019418 Pfam match to entry PF02979.5 NHase_alpha 216596019419 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 216596019420 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 216596019421 putative NAD(P) binding site [chemical binding]; other site 216596019422 active site 216596019423 DoxX-like family; Region: DoxX_3; pfam13781 216596019424 4 probable transmembrane helices predicted at aa 311-330, 345-367, 374-396 and 401-421 216596019425 Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027 216596019426 4 probable transmembrane helices predicted at aa 5-27, 39-61, 81-103 and 128-150 216596019427 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 216596019428 4 probable transmembrane helices predicted at aa 7-29, 44-66, 137-159 and 179-196 216596019429 Pfam match to entry PF01810.7 LysE 216596019430 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 216596019431 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 216596019432 active site 216596019433 catalytic tetrad [active] 216596019434 Pfam match to entry PF00248.9 Aldo_ket_red 216596019435 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 216596019436 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 216596019437 putative valine binding site [chemical binding]; other site 216596019438 dimer interface [polypeptide binding]; other site 216596019439 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 216596019440 Pfam match to entry PF01842.8 ACT 216596019441 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 216596019442 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 216596019443 PYR/PP interface [polypeptide binding]; other site 216596019444 dimer interface [polypeptide binding]; other site 216596019445 TPP binding site [chemical binding]; other site 216596019446 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 216596019447 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 216596019448 TPP-binding site [chemical binding]; other site 216596019449 dimer interface [polypeptide binding]; other site 216596019450 Pfam match to entry PF00205.10 TPP_enzyme_M 216596019451 Pfam match to entry PF02776.6 TPP_enzyme_N 216596019452 HerA helicase [Replication, recombination, and repair]; Region: COG0433 216596019453 Domain of unknown function DUF87; Region: DUF87; pfam01935 216596019454 Pfam match to entry PF01935.6 DUF87 216596019455 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 216596019456 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 216596019457 inhibitor site; inhibition site 216596019458 active site 216596019459 dimer interface [polypeptide binding]; other site 216596019460 catalytic residue [active] 216596019461 Pfam match to entry PF00701.10 DHDPS 216596019462 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 216596019463 Pfam match to entry PF01810 LysE 216596019464 6 probable transmembrane helices predicted at aa 4-26, 38-60, 64-86, 116-138,148-170 and 183-202 216596019465 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 216596019466 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596019467 DNA-binding site [nucleotide binding]; DNA binding site 216596019468 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216596019469 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596019470 homodimer interface [polypeptide binding]; other site 216596019471 catalytic residue [active] 216596019472 Pfam match to entry PF00392.9 GntR 216596019473 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 216596019474 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 216596019475 Pfam match to entry PF01715.6 IPPT 216596019476 Pfam match to entry PF01745.6 IPT 216596019477 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 216596019478 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216596019479 motif II; other site 216596019480 Pfam match to entry PF00702.10 Hydrolase 216596019481 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 216596019482 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 216596019483 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 216596019484 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 216596019485 protein binding site [polypeptide binding]; other site 216596019486 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 216596019487 protein binding site [polypeptide binding]; other site 216596019488 Pfam match to entry PF00595.8 PDZ 216596019489 Pfam match to entry PF00595.8 PDZ 216596019490 Pfam match to entry PF00089.9 Trypsin 216596019491 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 216596019492 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 216596019493 Pfam match to entry PF01145.11 Band_7 216596019494 1 probable transmembrane helix predicted at aa 7-29 216596019495 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 216596019496 HflK protein; Region: hflK; TIGR01933 216596019497 Pfam match to entry PF01145.11 Band_7 216596019498 1 probable transmembrane helix predicted at aa 57-79 216596019499 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 216596019500 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 216596019501 folate binding site [chemical binding]; other site 216596019502 NADP+ binding site [chemical binding]; other site 216596019503 Pfam match to entry PF00186.8 DHFR_1 216596019504 thymidylate synthase; Reviewed; Region: thyA; PRK01827 216596019505 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 216596019506 dimerization interface [polypeptide binding]; other site 216596019507 active site 216596019508 Pfam match to entry PF00303.7 Thymidylat_synt 216596019509 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3814 216596019510 Pfam match to entry PF07031.1 DUF1321 216596019511 Domain of unknown function (DUF4169); Region: DUF4169; pfam13770 216596019512 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 216596019513 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 216596019514 Pfam match to entry PF05170.2 AsmA 216596019515 1 probable transmembrane helix predicted at aa 5-27 216596019516 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 216596019517 FAD binding domain; Region: FAD_binding_4; pfam01565 216596019518 Pfam match to entry PF02913.7 FAD-oxidase_C 216596019519 Pfam match to entry PF01565.10 FAD_binding_4 216596019520 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 216596019521 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 216596019522 active site 216596019523 catalytic tetrad [active] 216596019524 Pfam match to entry PF00248.9 Aldo_ket_red 216596019525 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596019526 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596019527 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216596019528 dimerization interface [polypeptide binding]; other site 216596019529 Pfam match to entry PF00126.10 HTH_1 216596019530 Pfam match to entry PF03466.5 LysR_substrate 216596019531 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 216596019532 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 216596019533 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 216596019534 9 probable transmembrane helices predicted at aa 34-56, 63-85, 95-117, 158-177,192-211, 218-237, 241-263, 276-298 and 331-353 216596019535 Pfam match to entry PF05145.2 AmoA 216596019536 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 216596019537 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 216596019538 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216596019539 Pfam match to entry PF00165.8 HTH_AraC 216596019540 Pfam match to entry PF00165.8 HTH_AraC 216596019541 Pfam match to entry PF02311.7 AraC_binding 216596019542 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 216596019543 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 216596019544 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 216596019545 ligand binding site [chemical binding]; other site 216596019546 Pfam match to entry PF00691.7 OmpA 216596019547 flagellin; Reviewed; Region: PRK12687 216596019548 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 216596019549 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 216596019550 Pfam match to entry PF00700.8 Flagellin_C 216596019551 Pfam match to entry PF00669.8 Flagellin_N 216596019552 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 216596019553 Pfam match to entry PF00873.7 ACR_tran 216596019554 12 probable transmembrane helices predicted at aa 20-42, 343-362, 369-391, 395-417,440-462, 472-494, 531-553, 859-876, 881-903, 913-935,955-977 and 992-1014 216596019555 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 216596019556 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 216596019557 HlyD family secretion protein; Region: HlyD_3; pfam13437 216596019558 Pfam match to entry PF00529.8 HlyD 216596019559 1 probable transmembrane helix predicted at aa 7-29 216596019560 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 216596019561 cyclase homology domain; Region: CHD; cd07302 216596019562 nucleotidyl binding site; other site 216596019563 metal binding site [ion binding]; metal-binding site 216596019564 dimer interface [polypeptide binding]; other site 216596019565 4 probable transmembrane helices predicted at aa 212-231, 235-252, 259-281 and 285-304 216596019566 Pfam match to entry PF00211.9 Guanylate_cyc 216596019567 SpoVR family protein; Provisional; Region: PRK11767 216596019568 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 216596019569 Pfam match to entry PF04293.3 SpoVR 216596019570 hypothetical protein; Provisional; Region: PRK05325 216596019571 Pfam match to entry PF04285.2 DUF444 216596019572 PrkA family serine protein kinase; Provisional; Region: PRK15455 216596019573 AAA ATPase domain; Region: AAA_16; pfam13191 216596019574 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 216596019575 Pfam match to entry PF06798.1 PrkA 216596019576 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 216596019577 dimer interface [polypeptide binding]; other site 216596019578 Pfam match to entry PF06983.1 3-dmu-9_3-mt 216596019579 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 216596019580 Part of AAA domain; Region: AAA_19; pfam13245 216596019581 Family description; Region: UvrD_C_2; pfam13538 216596019582 Pfam match to entry PF00580.8 UvrD-helicase 216596019583 3 probable transmembrane helices predicted at aa 13-35, 48-70 and 85-107 216596019584 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 216596019585 Ca2+ binding site [ion binding]; other site 216596019586 Pfam match to entry PF00036.14 efhand 216596019587 Pfam match to entry PF00036.14 efhand 216596019588 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 216596019589 Isochorismatase family; Region: Isochorismatase; pfam00857 216596019590 catalytic triad [active] 216596019591 metal binding site [ion binding]; metal-binding site 216596019592 conserved cis-peptide bond; other site 216596019593 Pfam match to entry PF00857.9 Isochorismatase 216596019594 RibD C-terminal domain; Region: RibD_C; cl17279 216596019595 Pfam match to entry PF01872.7 RibD_C 216596019596 9 probable transmembrane helices predicted at aa 79-101, 131-153, 160-182,192-211, 223-245, 265-287, 299-318, 333-352 and 359-381 216596019597 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 216596019598 5 probable transmembrane helices predicted at aa 85-107, 140-159, 203-225, 235-252 and 259-278 216596019599 Pfam match to entry PF03591.3 AzlC 216596019600 Predicted membrane protein [Function unknown]; Region: COG4541 216596019601 Pfam match to entry PF06063.1 DUF931 216596019602 3 probable transmembrane helices predicted at aa 10-29, 42-61 and 71-93 216596019603 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 216596019604 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 216596019605 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 216596019606 active site 216596019607 Pfam match to entry PF00557.8 Peptidase_M24 216596019608 ABC transporter component, pseudogene; Similar to N-terminus to codon 45 of Bacillus cereus (strain ATCC 10987) ABC transporter, ATP-binding protein. UniProt:Q73A00_BACC1 (EMBL:AE017270) (314 aa); similarity:fasta; with=UniProt:Q73A00_BACC1 (EMBL:AE017270); Bacillus cereus (strain ATCC 10987).; ABC transporter, ATP-binding protein.; length=314; id 27.083; 48 aa overlap; query 1-45; subject 9-56 216596019609 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 216596019610 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596019611 S-adenosylmethionine binding site [chemical binding]; other site 216596019612 Pfam match to entry PF06325.2 PrmA 216596019613 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 216596019614 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 216596019615 Cu(I) binding site [ion binding]; other site 216596019616 Pfam match to entry PF02630.4 SCO1-SenC 216596019617 1 probable transmembrane helix predicted at aa 7-29 216596019618 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 216596019619 putative CheA interaction surface; other site 216596019620 Pfam match to entry PF01584.7 CheW 216596019621 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 216596019622 CreA protein; Region: CreA; pfam05981 216596019623 Pfam match to entry PF05981.1 CreA 216596019624 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 216596019625 active site 216596019626 catalytic site [active] 216596019627 substrate binding site [chemical binding]; other site 216596019628 Pfam match to entry PF00929.11 Exonuc_X-T 216596019629 putative acetyltransferase YhhY; Provisional; Region: PRK10140 216596019630 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216596019631 Coenzyme A binding pocket [chemical binding]; other site 216596019632 Pfam match to entry PF00583.9 Acetyltransf_1 216596019633 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 216596019634 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 216596019635 nucleotide binding pocket [chemical binding]; other site 216596019636 K-X-D-G motif; other site 216596019637 catalytic site [active] 216596019638 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 216596019639 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 216596019640 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 216596019641 Dimer interface [polypeptide binding]; other site 216596019642 BRCT sequence motif; other site 216596019643 Pfam match to entry PF00533.12 BRCT 216596019644 Pfam match to entry PF00633.11 HHH 216596019645 Pfam match to entry PF00633.11 HHH 216596019646 Pfam match to entry PF03119.4 DNA_ligase_ZBD 216596019647 Pfam match to entry PF03120.4 DNA_ligase_OB 216596019648 Pfam match to entry PF01653.7 DNA_ligase_aden 216596019649 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 216596019650 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 216596019651 Walker A/P-loop; other site 216596019652 ATP binding site [chemical binding]; other site 216596019653 Q-loop/lid; other site 216596019654 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 216596019655 ABC transporter signature motif; other site 216596019656 Walker B; other site 216596019657 D-loop; other site 216596019658 H-loop/switch region; other site 216596019659 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 216596019660 Pfam match to entry PF03696.3 UPF0169 216596019661 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 216596019662 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 216596019663 Pfam match to entry PF03331.3 LpxC 216596019664 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 216596019665 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 216596019666 nucleotide binding site [chemical binding]; other site 216596019667 SulA interaction site; other site 216596019668 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 216596019669 Pfam match to entry PF03953.5 Tubulin_C 216596019670 Pfam match to entry PF00091.13 Tubulin 216596019671 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 216596019672 Cell division protein FtsA; Region: FtsA; smart00842 216596019673 Cell division protein FtsA; Region: FtsA; pfam14450 216596019674 Pfam match to entry PF02491.7 FtsA 216596019675 Pfam match to entry PF02491.7 FtsA 216596019676 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 216596019677 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 216596019678 Cell division protein FtsQ; Region: FtsQ; pfam03799 216596019679 Pfam match to entry PF03799.3 FtsQ 216596019680 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 216596019681 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 216596019682 ATP-grasp domain; Region: ATP-grasp_4; cl17255 216596019683 Pfam match to entry PF07478.1 Dala_Dala_lig_C 216596019684 Pfam match to entry PF01820.9 Dala_Dala_lig_N 216596019685 aquaporin Z; Provisional; Region: PRK05420 216596019686 amphipathic channel; other site 216596019687 Asn-Pro-Ala signature motifs; other site 216596019688 Pfam match to entry PF00230 216596019689 6 probable transmembrane helices predicted at aa 43-65, 70-92, 119-141, 165-187,194-216 and 236-258 216596019690 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596019691 metabolite-proton symporter; Region: 2A0106; TIGR00883 216596019692 putative substrate translocation pore; other site 216596019693 Pfam match to entry PF00083.9 Sugar_tr 216596019694 12 probable transmembrane helices predicted at aa 27-49, 69-91, 98-117, 122-144,164-186, 201-220, 252-274, 294-316, 323-345, 355-377,384-406 and 416-435 216596019695 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 216596019696 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 216596019697 putative NAD(P) binding site [chemical binding]; other site 216596019698 active site 216596019699 putative substrate binding site [chemical binding]; other site 216596019700 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 216596019701 FAD binding domain; Region: FAD_binding_4; pfam01565 216596019702 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 216596019703 Pfam match to entry PF02873.4 MurB_C 216596019704 Pfam match to entry PF01565.10 FAD_binding_4 216596019705 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 216596019706 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 216596019707 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 216596019708 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 216596019709 Pfam match to entry PF02875.7 Mur_ligase_C 216596019710 Pfam match to entry PF01225.11 Mur_ligase 216596019711 1 probable transmembrane helix predicted at aa 7-24 216596019712 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 216596019713 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 216596019714 active site 216596019715 homodimer interface [polypeptide binding]; other site 216596019716 Pfam match to entry PF04101.4 Glyco_tran_28_C 216596019717 Pfam match to entry PF03033.7 Glyco_transf_28 216596019718 cell division protein FtsW; Region: ftsW; TIGR02614 216596019719 Pfam match to entry PF01098.8 FTSW_RODA_SPOVE 216596019720 8 probable transmembrane helices predicted at aa 21-43, 58-77, 84-103, 146-165,177-199, 268-290, 303-325 and 338-360 216596019721 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 216596019722 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 216596019723 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 216596019724 Pfam match to entry PF02875.7 Mur_ligase_C 216596019725 Pfam match to entry PF01225.11 Mur_ligase 216596019726 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 216596019727 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 216596019728 Mg++ binding site [ion binding]; other site 216596019729 putative catalytic motif [active] 216596019730 putative substrate binding site [chemical binding]; other site 216596019731 10 probable transmembrane helices predicted at aa 27-49, 69-91, 96-114, 135-154,174-196, 203-225, 240-262, 267-289, 294-316 and 344-363 216596019732 Pfam match to entry PF00953.8 Glycos_transf_4 216596019733 UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093 216596019734 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 216596019735 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 216596019736 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 216596019737 Pfam match to entry PF02875.7 Mur_ligase_C 216596019738 Pfam match to entry PF01225.11 Mur_ligase 216596019739 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 216596019740 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 216596019741 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 216596019742 Pfam match to entry PF02875.7 Mur_ligase_C 216596019743 Pfam match to entry PF01225.11 Mur_ligase 216596019744 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 216596019745 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 216596019746 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 216596019747 Pfam match to entry PF00905.8 Transpeptidase 216596019748 Pfam match to entry PF03717.4 PBP_dimer 216596019749 1 probable transmembrane helix predicted at aa 49-68 216596019750 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462 216596019751 MraW methylase family; Region: Methyltransf_5; cl17771 216596019752 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 216596019753 Pfam match to entry PF01795.8 Methyltransf_5 216596019754 cell division protein MraZ; Reviewed; Region: PRK00326 216596019755 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 216596019756 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 216596019757 hydroxyglutarate oxidase; Provisional; Region: PRK11728 216596019758 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 216596019759 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 216596019760 N-acetyl-D-glucosamine binding site [chemical binding]; other site 216596019761 catalytic residue [active] 216596019762 Pfam match to entry PF01464.7 SLT 216596019763 1 probable transmembrane helix predicted at aa 4-23 216596019764 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 216596019765 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 216596019766 amidase catalytic site [active] 216596019767 Zn binding residues [ion binding]; other site 216596019768 substrate binding site [chemical binding]; other site 216596019769 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 216596019770 Pfam match to entry PF01471.6 PG_binding_1 216596019771 Pfam match to entry PF01510.12 Amidase_2 216596019772 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 216596019773 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 216596019774 putative metal binding site [ion binding]; other site 216596019775 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 216596019776 HSP70 interaction site [polypeptide binding]; other site 216596019777 Pfam match to entry PF00226.13 DnaJ 216596019778 pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555 216596019779 6-phosphofructokinase [Carbohydrate transport and metabolism]; Region: PfkA; COG0205 216596019780 active site 216596019781 ADP/pyrophosphate binding site [chemical binding]; other site 216596019782 allosteric effector site; other site 216596019783 dimerization interface [polypeptide binding]; other site 216596019784 fructose-1,6-bisphosphate binding site; other site 216596019785 Pfam match to entry PF00365.7 PFK 216596019786 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 216596019787 5 probable transmembrane helices predicted at aa 10-32, 39-61, 66-88, 114-136 and 151-173 216596019788 Pfam match to entry PF01810.7 LysE 216596019789 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 216596019790 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 216596019791 N-acetyl-D-glucosamine binding site [chemical binding]; other site 216596019792 catalytic residue [active] 216596019793 Pfam match to entry PF01464.7 SLT 216596019794 Beta-lactamase; Region: Beta-lactamase; pfam00144 216596019795 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 216596019796 Pfam match to entry PF00144.9 Beta-lactamase 216596019797 1 probable transmembrane helix predicted at aa 58-80 216596019798 S-adenosylmethionine:diacylglycerol 3-amino-3-carboxypropyl transferase [Lipid metabolism]; Region: BtaA; COG5379 216596019799 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596019800 S-adenosylmethionine binding site [chemical binding]; other site 216596019801 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 216596019802 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 216596019803 active site 216596019804 Pfam match to entry PF01183.9 Glyco_hydro_25 216596019805 lytic murein transglycosylase; Region: MltB_2; TIGR02283 216596019806 murein hydrolase B; Provisional; Region: PRK10760; cl17906 216596019807 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 216596019808 1 probable transmembrane helix predicted at aa 5-24 216596019809 Pfam match to entry PF01471.6 PG_binding_1 216596019810 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 216596019811 EamA-like transporter family; Region: EamA; pfam00892 216596019812 EamA-like transporter family; Region: EamA; pfam00892 216596019813 10 probable transmembrane helices predicted at aa 7-29, 39-56, 69-91, 95-117,124-146, 151-173, 180-202, 217-239, 246-268 and 272-289 216596019814 Pfam match to entry PF00892.8 DUF6 216596019815 Pfam match to entry PF00892.8 DUF6 216596019816 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 216596019817 FAD binding site [chemical binding]; other site 216596019818 Pfam match to entry PF02219.5 MTHFR 216596019819 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216596019820 putative DNA binding site [nucleotide binding]; other site 216596019821 ubiquinone biosynthesis O-methyltransferase; Region: UbiG; TIGR01983 216596019822 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596019823 S-adenosylmethionine binding site [chemical binding]; other site 216596019824 Pfam match to entry PF01022.8 HTH_5 216596019825 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 216596019826 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216596019827 Walker A/P-loop; other site 216596019828 ATP binding site [chemical binding]; other site 216596019829 Q-loop/lid; other site 216596019830 ABC transporter signature motif; other site 216596019831 Walker B; other site 216596019832 D-loop; other site 216596019833 H-loop/switch region; other site 216596019834 ABC transporter; Region: ABC_tran_2; pfam12848 216596019835 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 216596019836 Pfam match to entry PF00005.11 ABC_tran 216596019837 Pfam match to entry PF00005.11 ABC_tran 216596019838 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 216596019839 B1 nucleotide binding pocket [chemical binding]; other site 216596019840 B2 nucleotide binding pocket [chemical binding]; other site 216596019841 CAS motifs; other site 216596019842 active site 216596019843 Pfam match to entry PF00445.8 Ribonuclease_T2 216596019844 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 216596019845 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 216596019846 Protein of unknown function (DUF2920); Region: DUF2920; pfam11144 216596019847 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 216596019848 EamA-like transporter family; Region: EamA; pfam00892 216596019849 EamA-like transporter family; Region: EamA; cl17759 216596019850 10 probable transmembrane helices predicted at aa 21-43, 48-67, 80-99, 103-125,132-149, 159-181, 193-210, 225-247, 252-274 and 279-298 216596019851 Pfam match to entry PF00892.8 DUF6 216596019852 Pfam match to entry PF00892.8 DUF6 216596019853 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 216596019854 CoA-transferase family III; Region: CoA_transf_3; pfam02515 216596019855 Pfam match to entry PF02515.5 CoA_transf_3 216596019856 thiamine pyrophosphate protein; Validated; Region: PRK08199 216596019857 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 216596019858 PYR/PP interface [polypeptide binding]; other site 216596019859 dimer interface [polypeptide binding]; other site 216596019860 TPP binding site [chemical binding]; other site 216596019861 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 216596019862 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 216596019863 TPP-binding site [chemical binding]; other site 216596019864 Pfam match to entry PF02776.6 TPP_enzyme_N 216596019865 Pfam match to entry PF00205.10 TPP_enzyme_M 216596019866 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 216596019867 homotrimer interaction site [polypeptide binding]; other site 216596019868 putative active site [active] 216596019869 Pfam match to entry PF01042.8 Ribonuc_L-PSP 216596019870 Putative phosphatase (DUF442); Region: DUF442; cl17385 216596019871 Pfam match to entry PF04273.2 DUF442 216596019872 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 216596019873 active site 216596019874 catalytic residues [active] 216596019875 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 216596019876 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 216596019877 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 216596019878 Pfam match to entry PF03734.4 ErfK_YbiS_YhnG 216596019879 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 216596019880 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 216596019881 P-loop; other site 216596019882 Magnesium ion binding site [ion binding]; other site 216596019883 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 216596019884 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 216596019885 putative active site [active] 216596019886 metal binding site [ion binding]; metal-binding site 216596019887 Pfam match to entry PF00465.7 Fe-ADH 216596019888 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 216596019889 Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102 216596019890 NAD(P) binding site [chemical binding]; other site 216596019891 catalytic residues [active] 216596019892 Pfam match to entry PF00171.9 Aldedh 216596019893 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 216596019894 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 216596019895 Pfam match to entry PF00120.9 Gln-synt_C 216596019896 Pfam match to entry PF03951.4 Gln-synt_N 216596019897 amino acid permease (GABA permease); Region: 2A0304; TIGR00907 216596019898 12 probable transmembrane helices predicted at aa 20-37, 47-69, 100-122, 137-159,168-190, 210-232, 256-278, 305-327, 356-375, 385-407,428-450 and 455-474 216596019899 Pfam match to entry PF00324.10 AA_permease 216596019900 N-formylglutamate amidohydrolase; Region: FGase; cl01522 216596019901 Pfam match to entry PF05013.2 FGase 216596019902 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 216596019903 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 216596019904 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 216596019905 putative active site [active] 216596019906 Pfam match to entry PF01418.7 HTH_6 216596019907 Pfam match to entry PF01380.9 SIS 216596019908 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 216596019909 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 216596019910 Pfam match to entry PF01547.11 SBP_bac_1 216596019911 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 216596019912 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4132 216596019913 7 probable transmembrane helices predicted at aa 32-54, 83-105, 125-147, 154-176,209-231, 238-260 and 270-292 216596019914 Pfam match to entry PF00528.10 BPD_transp_1 216596019915 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 216596019916 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596019917 dimer interface [polypeptide binding]; other site 216596019918 conserved gate region; other site 216596019919 putative PBP binding loops; other site 216596019920 ABC-ATPase subunit interface; other site 216596019921 6 probable transmembrane helices predicted at aa 12-34, 64-86, 93-115, 130-152,191-213 and 233-255 216596019922 Pfam match to entry PF00528.10 BPD_transp_1 216596019923 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 216596019924 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216596019925 Walker A/P-loop; other site 216596019926 ATP binding site [chemical binding]; other site 216596019927 Q-loop/lid; other site 216596019928 ABC transporter signature motif; other site 216596019929 Walker B; other site 216596019930 D-loop; other site 216596019931 H-loop/switch region; other site 216596019932 TOBE domain; Region: TOBE_2; pfam08402 216596019933 Pfam match to entry PF00005.11 ABC_tran 216596019934 NIPSNAP; Region: NIPSNAP; pfam07978 216596019935 Pfam match to entry PF06499.1 DUF1099 216596019936 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 216596019937 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 216596019938 Walker A/P-loop; other site 216596019939 ATP binding site [chemical binding]; other site 216596019940 Q-loop/lid; other site 216596019941 ABC transporter signature motif; other site 216596019942 Walker B; other site 216596019943 D-loop; other site 216596019944 H-loop/switch region; other site 216596019945 TOBE domain; Region: TOBE_2; pfam08402 216596019946 Pfam match to entry PF03459.4 TOBE 216596019947 Pfam match to entry PF00005.11 ABC_tran 216596019948 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 216596019949 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 216596019950 Pfam match to entry PF01408.8 GFO_IDH_MocA 216596019951 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216596019952 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596019953 dimer interface [polypeptide binding]; other site 216596019954 conserved gate region; other site 216596019955 putative PBP binding loops; other site 216596019956 ABC-ATPase subunit interface; other site 216596019957 Pfam match to entry PF00528.10 BPD_transp_1 216596019958 6 probable transmembrane helices predicted at aa 12-34, 77-99, 106-128, 143-165,186-208 and 244-266 216596019959 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 216596019960 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596019961 dimer interface [polypeptide binding]; other site 216596019962 conserved gate region; other site 216596019963 putative PBP binding loops; other site 216596019964 ABC-ATPase subunit interface; other site 216596019965 Pfam match to entry PF00528.10 BPD_transp_1 216596019966 6 probable transmembrane helices predicted at aa 86-108, 153-175, 188-210,225-247, 288-310 and 351-373 216596019967 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 216596019968 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 216596019969 Pfam match to entry PF01547.11 SBP_bac_1 216596019970 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 216596019971 Pfam match to entry PF01869.8 BcrAD_BadFG 216596019972 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 216596019973 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596019974 DNA-binding site [nucleotide binding]; DNA binding site 216596019975 UTRA domain; Region: UTRA; pfam07702 216596019976 Pfam match to entry PF00392.9 GntR 216596019977 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 216596019978 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 216596019979 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 216596019980 substrate binding pocket [chemical binding]; other site 216596019981 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 216596019982 B12 binding site [chemical binding]; other site 216596019983 cobalt ligand [ion binding]; other site 216596019984 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 216596019985 Pfam match to entry PF02965.5 Met_synt_B12 216596019986 Pfam match to entry PF02310.8 B12-binding 216596019987 Pfam match to entry PF02607.6 B12-binding_2 216596019988 Pfam match to entry PF00809.8 Pterin_bind 216596019989 Pfam match to entry PF02574.5 S-methyl_trans 216596019990 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 216596019991 dimerization interface [polypeptide binding]; other site 216596019992 putative active cleft [active] 216596019993 Pfam match to entry PF07221.1 GlcNAc_2-epim 216596019994 hypothetical protein; Provisional; Region: PRK02487 216596019995 Pfam match to entry PF06142.1 DUF967 216596019996 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 216596019997 Pfam match to entry PF01613.6 Flavin_Reduct 216596019998 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 216596019999 Pfam match to entry PF01177.8 Asp_Glu_race 216596020000 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 216596020001 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596020002 dimer interface [polypeptide binding]; other site 216596020003 conserved gate region; other site 216596020004 putative PBP binding loops; other site 216596020005 ABC-ATPase subunit interface; other site 216596020006 Pfam match to entry PF00528.10 BPD_transp_1 216596020007 6 probable transmembrane helices predicted at aa 12-34, 75-94, 106-128, 143-165,186-208 and 239-261 216596020008 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596020009 dimer interface [polypeptide binding]; other site 216596020010 conserved gate region; other site 216596020011 putative PBP binding loops; other site 216596020012 ABC-ATPase subunit interface; other site 216596020013 Pfam match to entry PF00528.10 BPD_transp_1 216596020014 6 probable transmembrane helices predicted at aa 35-57, 93-115, 122-144, 175-197,218-240 and 273-295 216596020015 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 216596020016 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 216596020017 1 probable transmembrane helix predicted at aa 22-44 216596020018 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 216596020019 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216596020020 Walker A/P-loop; other site 216596020021 ATP binding site [chemical binding]; other site 216596020022 Q-loop/lid; other site 216596020023 ABC transporter signature motif; other site 216596020024 Walker B; other site 216596020025 D-loop; other site 216596020026 H-loop/switch region; other site 216596020027 TOBE domain; Region: TOBE_2; pfam08402 216596020028 Pfam match to entry PF00005.11 ABC_tran 216596020029 Transcriptional regulators [Transcription]; Region: GntR; COG1802 216596020030 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596020031 DNA-binding site [nucleotide binding]; DNA binding site 216596020032 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 216596020033 Pfam match to entry PF00392.9 GntR 216596020034 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 216596020035 N-terminal catalytic domain of mainly uncharacterized eukaryotic proteins similar to alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like_1; cd10791 216596020036 putative active site [active] 216596020037 catalytic site [active] 216596020038 Autoinducer binding domain; Region: Autoind_bind; pfam03472 216596020039 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216596020040 DNA binding residues [nucleotide binding] 216596020041 dimerization interface [polypeptide binding]; other site 216596020042 Pfam match to entry PF03472.4 Autoind_bind 216596020043 Pfam match to entry PF00196.8 GerE 216596020044 Autoinducer synthetase; Region: Autoind_synth; cl17404 216596020045 Pfam match to entry PF00765.7 Autoind_synth 216596020046 Response regulator receiver domain; Region: Response_reg; pfam00072 216596020047 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596020048 active site 216596020049 phosphorylation site [posttranslational modification] 216596020050 intermolecular recognition site; other site 216596020051 dimerization interface [polypeptide binding]; other site 216596020052 Pfam match to entry PF00072.9 Response_reg 216596020053 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 216596020054 Coenzyme A binding pocket [chemical binding]; other site 216596020055 Pfam match to entry PF00583.9 Acetyltransf_1 216596020056 1 probable transmembrane helix predicted at aa 90-112 216596020057 Uncharacterized conserved protein [Function unknown]; Region: COG2968 216596020058 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 216596020059 Pfam match to entry PF04402.3 DUF541 216596020060 Uncharacterized conserved protein [Function unknown]; Region: COG0432 216596020061 Pfam match to entry PF01894.6 UPF0047 216596020062 Protein of unknown function (DUF1428); Region: DUF1428; cl02319 216596020063 Pfam match to entry PF07237.1 DUF1428 216596020064 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 216596020065 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216596020066 motif II; other site 216596020067 Pfam match to entry PF00702.10 Hydrolase 216596020068 similarity:fasta; with=UniProt:Q92U22_RHIME (EMBL:RME591985); Rhizobium meliloti (Sinorhizobium meliloti).; Hypothetical protein SMb21492.; length=220; id 58.685; 213 aa overlap; query 1-209; subject 8-219 216596020069 Pfam match to entry PF06037.1 DUF922 216596020070 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596020071 putative substrate translocation pore; other site 216596020072 10 probable transmembrane helices predicted at aa 20-42, 47-69, 81-100, 104-123,144-166, 170-192, 220-242, 257-276, 289-320 and 369-391 216596020073 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 216596020074 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 216596020075 ligand binding site [chemical binding]; other site 216596020076 flexible hinge region; other site 216596020077 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 216596020078 Pfam match to entry PF00027.13 cNMP_binding 216596020079 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 216596020080 Pfam match to entry PF04248.2 DUF427 216596020081 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 216596020082 B3/4 domain; Region: B3_4; pfam03483 216596020083 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 216596020084 EamA-like transporter family; Region: EamA; pfam00892 216596020085 EamA-like transporter family; Region: EamA; pfam00892 216596020086 10 probable transmembrane helices predicted at aa 7-29, 39-61, 68-90, 95-117,124-143, 148-170, 177-199, 209-231, 243-262 and 266-288 216596020087 Pfam match to entry PF00892.8 DUF6 216596020088 Pfam match to entry PF00892.8 DUF6 216596020089 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 216596020090 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216596020091 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216596020092 Pfam match to entry PF00165.8 HTH_AraC 216596020093 Pfam match to entry PF00165.8 HTH_AraC 216596020094 Pfam match to entry PF02311.7 AraC_binding 216596020095 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 216596020096 Phosphotransferase enzyme family; Region: APH; pfam01636 216596020097 active site 216596020098 ATP binding site [chemical binding]; other site 216596020099 antibiotic binding site [chemical binding]; other site 216596020100 Pfam match to entry PF01636.8 APH 216596020101 Domain of Unknown Function (DUF930); Region: DUF930; pfam06059 216596020102 Pfam match to entry PF06059.1 DUF930 216596020103 1 probable transmembrane helix predicted at aa 21-43 216596020104 Domain of Unknown Function (DUF930); Region: DUF930; pfam06059 216596020105 Pfam match to entry PF06059.1 DUF930 216596020106 1 probable transmembrane helix predicted at aa 12-34 216596020107 Uncharacterized conserved protein [Function unknown]; Region: COG4274 216596020108 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 216596020109 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 216596020110 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 216596020111 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 216596020112 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216596020113 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 216596020114 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 216596020115 DNA binding residues [nucleotide binding] 216596020116 Pfam match to entry PF04545.3 Sigma70_r4 216596020117 Pfam match to entry PF04539.2 Sigma70_r3 216596020118 Pfam match to entry PF04542.2 Sigma70_r2 216596020119 Pfam match to entry PF00140.8 Sigma70_r1_2 216596020120 Pfam match to entry PF03979.3 Sigma70_r1_1 216596020121 Uncharacterized conserved protein [Function unknown]; Region: COG3791 216596020122 Pfam match to entry PF04828.3 DUF636 216596020123 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 216596020124 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 216596020125 NAD(P) binding site [chemical binding]; other site 216596020126 Pfam match to entry PF00107.10 ADH_zinc_N 216596020127 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 216596020128 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 216596020129 substrate-cofactor binding pocket; other site 216596020130 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596020131 catalytic residue [active] 216596020132 Pfam match to entry PF00155.8 Aminotran_1_2 216596020133 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596020134 S-adenosylmethionine binding site [chemical binding]; other site 216596020135 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 216596020136 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 216596020137 ATP binding site [chemical binding]; other site 216596020138 putative Mg++ binding site [ion binding]; other site 216596020139 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216596020140 nucleotide binding region [chemical binding]; other site 216596020141 ATP-binding site [chemical binding]; other site 216596020142 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 216596020143 HRDC domain; Region: HRDC; pfam00570 216596020144 Pfam match to entry PF00570.11 HRDC 216596020145 Pfam match to entry PF00271.13 Helicase_C 216596020146 Pfam match to entry PF00270.12 DEAD 216596020147 DNA primase; Validated; Region: dnaG; PRK05667 216596020148 CHC2 zinc finger; Region: zf-CHC2; cl17510 216596020149 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 216596020150 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 216596020151 active site 216596020152 metal binding site [ion binding]; metal-binding site 216596020153 interdomain interaction site; other site 216596020154 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 216596020155 Pfam match to entry PF01751.7 Toprim 216596020156 Pfam match to entry PF01807.7 zf-CHC2 216596020157 DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is...; Region: DEP; cl02442 216596020158 Yqey-like protein; Region: YqeY; pfam09424 216596020159 Pfam match to entry PF02637.5 GatB_Yqey 216596020160 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 216596020161 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 216596020162 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 216596020163 catalytic site [active] 216596020164 subunit interface [polypeptide binding]; other site 216596020165 Pfam match to entry PF00988.9 CPSase_sm_chain 216596020166 Pfam match to entry PF00117.10 GATase 216596020167 multidrug efflux protein; Reviewed; Region: PRK01766 216596020168 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 216596020169 cation binding site [ion binding]; other site 216596020170 12 probable transmembrane helices predicted at aa 20-42, 62-84, 105-127, 142-164,171-193, 203-225, 260-282, 292-314, 327-349, 369-391,404-426 and 436-458 216596020171 Pfam match to entry PF01554.8 MatE 216596020172 Pfam match to entry PF01554.8 MatE 216596020173 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216596020174 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596020175 putative substrate translocation pore; other site 216596020176 Pfam match to entry PF00083.9 Sugar_tr 216596020177 10 probable transmembrane helices predicted at aa 12-34, 49-71, 83-105, 110-127,139-161, 166-188, 218-240, 255-274, 287-309 and 376-398 216596020178 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 216596020179 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 216596020180 active site 216596020181 catalytic tetrad [active] 216596020182 Pfam match to entry PF00248.9 Aldo_ket_red 216596020183 Predicted metalloprotease [General function prediction only]; Region: COG2321 216596020184 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 216596020185 Pfam match to entry PF04228.2 Zn_peptidase 216596020186 1 probable transmembrane helix predicted at aa 47-66 216596020187 Predicted membrane protein [Function unknown]; Region: COG5395 216596020188 5 probable transmembrane helices predicted at aa 15-34, 46-65, 70-92, 105-124 and 134-156 216596020189 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 216596020190 LytTr DNA-binding domain; Region: LytTR; smart00850 216596020191 4 probable transmembrane helices predicted at aa 21-39, 54-76, 83-105 and 120-142 216596020192 Pfam match to entry PF04397.4 LytTR 216596020193 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 216596020194 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 216596020195 ATP-grasp domain; Region: ATP-grasp_4; cl17255 216596020196 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 216596020197 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 216596020198 ATP-grasp domain; Region: ATP-grasp_4; cl17255 216596020199 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 216596020200 IMP binding site; other site 216596020201 dimer interface [polypeptide binding]; other site 216596020202 partial ornithine binding site; other site 216596020203 Pfam match to entry PF00289.9 CPSase_L_chain 216596020204 Pfam match to entry PF02786.4 CPSase_L_D2 216596020205 Pfam match to entry PF02787.5 CPSase_L_D3 216596020206 Pfam match to entry PF00289.9 CPSase_L_chain 216596020207 Pfam match to entry PF02786.4 CPSase_L_D2 216596020208 Pfam match to entry PF02142.8 MGS 216596020209 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 216596020210 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 216596020211 Fe-S cluster binding site [ion binding]; other site 216596020212 active site 216596020213 Pfam match to entry PF03167.6 UDG 216596020214 Predicted DNA-binding protein with the Helix-hairpin-helix motif [General function prediction only]; Region: COG4277 216596020215 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 216596020216 FeS/SAM binding site; other site 216596020217 Pfam match to entry PF04055.4 Radical_SAM 216596020218 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 216596020219 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 216596020220 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 216596020221 Pfam match to entry PF03449.3 GreA_GreB_N 216596020222 Pfam match to entry PF01272.7 GreA_GreB 216596020223 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 216596020224 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 216596020225 Pfam match to entry PF00534.8 Glycos_transf_1 216596020226 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 216596020227 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 216596020228 Pfam match to entry PF00375.7 SDF 216596020229 9 probable transmembrane helices predicted at aa 18-40, 53-75, 90-112, 142-159,163-180, 201-222, 232-254, 327-349 and 364-386 216596020230 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 216596020231 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216596020232 dimer interface [polypeptide binding]; other site 216596020233 phosphorylation site [posttranslational modification] 216596020234 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596020235 ATP binding site [chemical binding]; other site 216596020236 Mg2+ binding site [ion binding]; other site 216596020237 G-X-G motif; other site 216596020238 1 probable transmembrane helix predicted at aa 26-45 216596020239 Pfam match to entry PF00512.10 HisKA 216596020240 Pfam match to entry PF02518.9 HATPase_c 216596020241 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 216596020242 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596020243 active site 216596020244 phosphorylation site [posttranslational modification] 216596020245 intermolecular recognition site; other site 216596020246 dimerization interface [polypeptide binding]; other site 216596020247 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216596020248 Walker A motif; other site 216596020249 ATP binding site [chemical binding]; other site 216596020250 Walker B motif; other site 216596020251 arginine finger; other site 216596020252 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 216596020253 Pfam match to entry PF00072.9 Response_reg 216596020254 Pfam match to entry PF00158.12 Sigma54_activat 216596020255 Pfam match to entry PF02954.7 HTH_8 216596020256 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 216596020257 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216596020258 putative DNA binding site [nucleotide binding]; other site 216596020259 putative Zn2+ binding site [ion binding]; other site 216596020260 AsnC family; Region: AsnC_trans_reg; pfam01037 216596020261 Pfam match to entry PF01037.8 AsnC_trans_reg 216596020262 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 216596020263 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 216596020264 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 216596020265 Pfam match to entry PF00070.12 Pyr_redox 216596020266 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596020267 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596020268 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 216596020269 putative effector binding pocket; other site 216596020270 dimerization interface [polypeptide binding]; other site 216596020271 Pfam match to entry PF00126.10 HTH_1 216596020272 Pfam match to entry PF03466.5 LysR_substrate 216596020273 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216596020274 dimerization interface [polypeptide binding]; other site 216596020275 putative DNA binding site [nucleotide binding]; other site 216596020276 putative Zn2+ binding site [ion binding]; other site 216596020277 Pfam match to entry PF01022.8 HTH_5 216596020278 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 216596020279 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596020280 putative substrate translocation pore; other site 216596020281 12 probable transmembrane helices predicted at aa 5-27, 37-59, 72-94, 99-121,128-150, 160-179, 200-222, 237-256, 263-285, 295-317,324-346 and 356-378 216596020282 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 216596020283 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 216596020284 FMN binding site [chemical binding]; other site 216596020285 active site 216596020286 substrate binding site [chemical binding]; other site 216596020287 catalytic residue [active] 216596020288 Pfam match to entry PF00724.7 Oxidored_FMN 216596020289 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 216596020290 Pfam match to entry PF04655.2 APH_6_hur 216596020291 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216596020292 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 216596020293 NAD(P) binding site [chemical binding]; other site 216596020294 active site 216596020295 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596020296 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596020297 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216596020298 dimerization interface [polypeptide binding]; other site 216596020299 Pfam match to entry PF00126.10 HTH_1 216596020300 Pfam match to entry PF03466.5 LysR_substrate 216596020301 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 216596020302 Pfam match to entry PF04229.3 UPF0157 216596020303 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 216596020304 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 216596020305 11 probable transmembrane helices predicted at aa 12-31, 36-58, 71-93, 104-126,138-160, 164-183, 219-241, 251-273, 286-308, 313-335 and 342-364 216596020306 Pfam match to entry PF01699.11 Na_Ca_ex 216596020307 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 216596020308 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 216596020309 Ligand binding site; other site 216596020310 metal-binding site 216596020311 Pfam match to entry PF01501.8 Glyco_transf_8 216596020312 PIN domain nuclease, a component of toxin-antitoxin system (PIN domain) [Signal transduction mechanisms]; Region: COG3744 216596020313 putative active site [active] 216596020314 Pfam match to entry PF01850.8 PIN 216596020315 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 216596020316 aspartate aminotransferase; Provisional; Region: PRK05764 216596020317 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216596020318 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596020319 homodimer interface [polypeptide binding]; other site 216596020320 catalytic residue [active] 216596020321 Pfam match to entry PF00155.8 Aminotran_1_2 216596020322 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 216596020323 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 216596020324 vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to...; Region: vWA_interalpha_trypsin_inhibitor; cd01461 216596020325 metal ion-dependent adhesion site (MIDAS); other site 216596020326 2 probable transmembrane helices predicted at aa 88-110 and 832-849 216596020327 Pfam match to entry PF00092.11 VWA 216596020328 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 216596020329 active site 216596020330 catalytic site [active] 216596020331 1 probable transmembrane helix predicted at aa 55-77 216596020332 Pfam match to entry PF04203.3 Sortase 216596020333 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 216596020334 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 216596020335 EamA-like transporter family; Region: EamA; pfam00892 216596020336 10 probable transmembrane helices predicted at aa 7-28, 32-54, 67-89, 99-116,123-145, 149-171, 178-200, 210-232, 239-261 and 266-288 216596020337 Pfam match to entry PF00892.8 DUF6 216596020338 Pfam match to entry PF00892.8 DUF6 216596020339 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 216596020340 DNA-binding site [nucleotide binding]; DNA binding site 216596020341 RNA-binding motif; other site 216596020342 Pfam match to entry PF00313.8 CSD 216596020343 BA14K-like protein; Region: BA14K; pfam07886 216596020344 2 probable transmembrane helices predicted at aa 48-67 and 82-104 216596020345 short chain dehydrogenase; Provisional; Region: PRK06180 216596020346 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 216596020347 NADP binding site [chemical binding]; other site 216596020348 active site 216596020349 steroid binding site; other site 216596020350 Pfam match to entry PF00106.11 adh_short 216596020351 Predicted transcriptional regulators [Transcription]; Region: COG1733 216596020352 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 216596020353 Pfam match to entry PF01638.6 DUF24 216596020354 HAMP domain; Region: HAMP; pfam00672 216596020355 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596020356 ATP binding site [chemical binding]; other site 216596020357 Mg2+ binding site [ion binding]; other site 216596020358 G-X-G motif; other site 216596020359 Pfam match to entry PF02518.9 HATPase_c 216596020360 Pfam match to entry PF00512.10 HisKA 216596020361 Pfam match to entry PF00672.10 HAMP 216596020362 2 probable transmembrane helices predicted at aa 34-56 and 181-203 216596020363 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 216596020364 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596020365 active site 216596020366 phosphorylation site [posttranslational modification] 216596020367 intermolecular recognition site; other site 216596020368 dimerization interface [polypeptide binding]; other site 216596020369 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216596020370 DNA binding site [nucleotide binding] 216596020371 Pfam match to entry PF00486.11 Trans_reg_C 216596020372 Pfam match to entry PF00072.9 Response_reg 216596020373 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 216596020374 MarR family; Region: MarR_2; pfam12802 216596020375 Pfam match to entry PF01047.8 MarR 216596020376 3 probable transmembrane helices predicted at aa 15-37, 44-66 and 76-98 216596020377 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 216596020378 Bacterial SH3 domain; Region: SH3_3; pfam08239 216596020379 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 216596020380 Pfam match to entry PF06823.1 DUF1236 216596020381 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 216596020382 Pfam match to entry PF00753.12 Lactamase_B 216596020383 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 216596020384 dimer interface [polypeptide binding]; other site 216596020385 putative tRNA-binding site [nucleotide binding]; other site 216596020386 Pfam match to entry PF01588.6 tRNA_bind 216596020387 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 216596020388 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 216596020389 Pfam match to entry PF01089.8 P5CR 216596020390 Uncharacterized conserved protein [Function unknown]; Region: COG5465 216596020391 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 216596020392 Pfam match to entry PF01790.7 LGT 216596020393 7 probable transmembrane helices predicted at aa 20-42, 71-91, 106-128, 135-157,188-210, 217-234 and 249-271 216596020394 Uncharacterized conserved protein [Function unknown]; Region: COG1565 216596020395 Pfam match to entry PF02636.4 DUF185 216596020396 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 216596020397 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 216596020398 Pfam match to entry PF02578.4 DUF152 216596020399 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 216596020400 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 216596020401 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 216596020402 active site 216596020403 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 216596020404 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 216596020405 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 216596020406 active site 216596020407 Pfam match to entry PF00156.11 Pribosyltran 216596020408 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 216596020409 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 216596020410 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 216596020411 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216596020412 metal binding site [ion binding]; metal-binding site 216596020413 active site 216596020414 I-site; other site 216596020415 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216596020416 Pfam match to entry PF00563.9 EAL 216596020417 Pfam match to entry PF00990.8 GGDEF 216596020418 7 probable transmembrane helices predicted at aa 15-37, 49-68, 83-105, 110-132,142-164, 177-199 and 214-236 216596020419 Pfam match to entry PF03707.5 MHYT 216596020420 Pfam match to entry PF03707.5 MHYT 216596020421 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 216596020422 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 216596020423 5S rRNA interface [nucleotide binding]; other site 216596020424 CTC domain interface [polypeptide binding]; other site 216596020425 L16 interface [polypeptide binding]; other site 216596020426 Pfam match to entry PF01386.7 Ribosomal_L25p 216596020427 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 216596020428 dimerization interface [polypeptide binding]; other site 216596020429 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216596020430 PAS domain; Region: PAS_9; pfam13426 216596020431 putative active site [active] 216596020432 heme pocket [chemical binding]; other site 216596020433 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 216596020434 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216596020435 metal binding site [ion binding]; metal-binding site 216596020436 active site 216596020437 I-site; other site 216596020438 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216596020439 2 probable transmembrane helices predicted at aa 83-105 and 220-239 216596020440 Pfam match to entry PF00672.10 HAMP 216596020441 Pfam match to entry PF00989.11 PAS 216596020442 Pfam match to entry PF00990.8 GGDEF 216596020443 Pfam match to entry PF00563.9 EAL 216596020444 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 216596020445 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 216596020446 substrate binding pocket [chemical binding]; other site 216596020447 membrane-bound complex binding site; other site 216596020448 hinge residues; other site 216596020449 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 216596020450 putative active site [active] 216596020451 catalytic residue [active] 216596020452 Pfam match to entry PF01195.8 Pept_tRNA_hydro 216596020453 putative acetyltransferase; Provisional; Region: PRK03624 216596020454 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216596020455 Coenzyme A binding pocket [chemical binding]; other site 216596020456 Pfam match to entry PF00583.9 Acetyltransf_1 216596020457 ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019 216596020458 Pfam match to entry PF02617.4 ClpS 216596020459 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 216596020460 putative active site [active] 216596020461 Pfam match to entry PF01850.8 PIN 216596020462 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 216596020463 GTP-binding protein YchF; Reviewed; Region: PRK09601 216596020464 YchF GTPase; Region: YchF; cd01900 216596020465 G1 box; other site 216596020466 GTP/Mg2+ binding site [chemical binding]; other site 216596020467 Switch I region; other site 216596020468 G2 box; other site 216596020469 Switch II region; other site 216596020470 G3 box; other site 216596020471 G4 box; other site 216596020472 G5 box; other site 216596020473 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 216596020474 Pfam match to entry PF06071.1 DUF933 216596020475 9 probable transmembrane helices predicted at aa 71-93, 110-132, 142-161, 168-190,205-227, 240-259, 269-291, 296-313 and 323-345 216596020476 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 216596020477 putative active site [active] 216596020478 putative catalytic site [active] 216596020479 Pfam match to entry PF01575.6 MaoC_dehydratas 216596020480 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 216596020481 putative active site [active] 216596020482 putative catalytic site [active] 216596020483 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 216596020484 active site 216596020485 Pfam match to entry PF00156.11 Pribosyltran 216596020486 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 216596020487 Pfam match to entry PF02167.5 Cytochrom_C1 216596020488 1 probable transmembrane helix predicted at aa 266-283 216596020489 cytochrome b; Provisional; Region: CYTB; MTH00191 216596020490 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 216596020491 Qi binding site; other site 216596020492 intrachain domain interface; other site 216596020493 interchain domain interface [polypeptide binding]; other site 216596020494 heme bH binding site [chemical binding]; other site 216596020495 heme bL binding site [chemical binding]; other site 216596020496 Qo binding site; other site 216596020497 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 216596020498 interchain domain interface [polypeptide binding]; other site 216596020499 intrachain domain interface; other site 216596020500 Qi binding site; other site 216596020501 Qo binding site; other site 216596020502 9 probable transmembrane helices predicted at aa 46-68, 89-111, 126-148, 155-177,197-219, 246-268, 312-331, 344-363 and 373-395 216596020503 Pfam match to entry PF00032.7 Cytochrom_B_C 216596020504 Pfam match to entry PF00033.8 Cytochrom_B_N 216596020505 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 216596020506 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 216596020507 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 216596020508 [2Fe-2S] cluster binding site [ion binding]; other site 216596020509 Pfam match to entry PF00355.13 Rieske 216596020510 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 216596020511 putative catalytic site [active] 216596020512 putative metal binding site [ion binding]; other site 216596020513 putative phosphate binding site [ion binding]; other site 216596020514 3 probable transmembrane helices predicted at aa 5-22, 32-54 and 59-78 216596020515 Pfam match to entry PF03372.6 Exo_endo_phos 216596020516 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 216596020517 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 216596020518 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216596020519 Walker A/P-loop; other site 216596020520 ATP binding site [chemical binding]; other site 216596020521 Q-loop/lid; other site 216596020522 ABC transporter signature motif; other site 216596020523 Walker B; other site 216596020524 D-loop; other site 216596020525 H-loop/switch region; other site 216596020526 Pfam match to entry PF00005.11 ABC_tran 216596020527 Pfam match to entry PF00664.9 ABC_membrane 216596020528 6 probable transmembrane helices predicted at aa 44-66, 91-113, 164-186, 191-213,273-295 and 300-322 216596020529 Predicted transcriptional regulator [Transcription]; Region: COG3905 216596020530 Pfam match to entry PF01402.8 HTH_4 216596020531 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 216596020532 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 216596020533 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 216596020534 Walker A/P-loop; other site 216596020535 ATP binding site [chemical binding]; other site 216596020536 Q-loop/lid; other site 216596020537 ABC transporter signature motif; other site 216596020538 Walker B; other site 216596020539 D-loop; other site 216596020540 H-loop/switch region; other site 216596020541 Pfam match to entry PF00005.11 ABC_tran 216596020542 Pfam match to entry PF00664.9 ABC_membrane 216596020543 6 probable transmembrane helices predicted at aa 38-60, 83-105, 162-180, 184-203,265-283 and 287-309 216596020544 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 216596020545 Pfam match to entry PF00588.7 SpoU_methylase 216596020546 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 216596020547 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 216596020548 PhoU domain; Region: PhoU; pfam01895 216596020549 PhoU domain; Region: PhoU; pfam01895 216596020550 7 probable transmembrane helices predicted at aa 5-24, 53-75, 87-109, 129-151,164-186, 201-223 and 244-266 216596020551 Pfam match to entry PF02690.5 Na_Pi_cotrans 216596020552 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 216596020553 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752 216596020554 Pfam match to entry PF01218.7 Coprogen_oxidas 216596020555 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 216596020556 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 216596020557 active site 216596020558 NTP binding site [chemical binding]; other site 216596020559 metal binding triad [ion binding]; metal-binding site 216596020560 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 216596020561 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 216596020562 Pfam match to entry PF01743.7 PolyA_pol 216596020563 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 216596020564 putative active site [active] 216596020565 putative CoA binding site [chemical binding]; other site 216596020566 nudix motif; other site 216596020567 metal binding site [ion binding]; metal-binding site 216596020568 Pfam match to entry PF00293.12 NUDIX 216596020569 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816 216596020570 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 216596020571 Pfam match to entry PF06938.1 DUF1285 216596020572 MoxR-like ATPases [General function prediction only]; Region: COG0714 216596020573 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216596020574 Walker A motif; other site 216596020575 ATP binding site [chemical binding]; other site 216596020576 Walker B motif; other site 216596020577 arginine finger; other site 216596020578 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 216596020579 Protein of unknown function DUF58; Region: DUF58; pfam01882 216596020580 Pfam match to entry PF01882.7 DUF58 216596020581 N-terminal double-transmembrane domain; Region: two_anch; TIGR02226 216596020582 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 216596020583 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 216596020584 4 probable transmembrane helices predicted at aa 5-27, 60-82, 629-651 and 658-680 216596020585 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 216596020586 2 probable transmembrane helices predicted at aa 7-29 and 663-685 216596020587 Coenzyme A binding pocket [chemical binding]; other site 216596020588 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 216596020589 Pfam match to entry PF00583.9 Acetyltransf_1 216596020590 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 216596020591 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216596020592 Coenzyme A binding pocket [chemical binding]; other site 216596020593 Pfam match to entry PF00583.9 Acetyltransf_1 216596020594 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 216596020595 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 216596020596 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 216596020597 putative dimer interface [polypeptide binding]; other site 216596020598 N-terminal domain interface [polypeptide binding]; other site 216596020599 putative substrate binding pocket (H-site) [chemical binding]; other site 216596020600 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 216596020601 nudix motif; other site 216596020602 Pfam match to entry PF00293.12 NUDIX 216596020603 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 216596020604 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 216596020605 putative active site [active] 216596020606 putative metal binding site [ion binding]; other site 216596020607 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 216596020608 Pfam match to entry PF00149.12 Metallophos 216596020609 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216596020610 binding surface 216596020611 Tetratricopeptide repeat; Region: TPR_16; pfam13432 216596020612 TPR motif; other site 216596020613 1 probable transmembrane helix predicted at aa 7-29 216596020614 RNA polymerase sigma factor; Provisional; Region: PRK12547 216596020615 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216596020616 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 216596020617 DNA binding residues [nucleotide binding] 216596020618 Pfam match to entry PF04542.2 Sigma70_r2 216596020619 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 216596020620 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 216596020621 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 216596020622 NAD(P) binding site [chemical binding]; other site 216596020623 Pfam match to entry PF00107.10 ADH_zinc_N 216596020624 Predicted transcriptional regulators [Transcription]; Region: COG1733 216596020625 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 216596020626 Pfam match to entry PF01638.6 DUF24 216596020627 2-isopropylmalate synthase; Validated; Region: PRK03739 216596020628 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 216596020629 active site 216596020630 catalytic residues [active] 216596020631 metal binding site [ion binding]; metal-binding site 216596020632 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 216596020633 Pfam match to entry PF00682.8 HMGL-like 216596020634 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 216596020635 benzoate transporter; Region: benE; TIGR00843 216596020636 11 probable transmembrane helices predicted at aa 30-52, 65-87, 111-133, 140-162,166-185, 190-208, 228-250, 279-301, 316-338, 345-367 and 387-409 216596020637 Pfam match to entry PF03594.3 BenE 216596020638 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 216596020639 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 216596020640 oligomer interface [polypeptide binding]; other site 216596020641 active site residues [active] 216596020642 Pfam match to entry PF00574.9 CLP_protease 216596020643 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 216596020644 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 216596020645 Pfam match to entry PF01227.10 GTP_cyclohydroI 216596020646 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 216596020647 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 216596020648 Pfam match to entry PF01545.9 Cation_efflux 216596020649 5 probable transmembrane helices predicted at aa 30-52, 56-78, 98-117, 132-154 and 175-197 216596020650 Uncharacterized conserved protein (DUF2161); Region: DUF2161; cl02298 216596020651 anthranilate synthase; Provisional; Region: PRK13566 216596020652 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 216596020653 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 216596020654 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 216596020655 glutamine binding [chemical binding]; other site 216596020656 catalytic triad [active] 216596020657 Pfam match to entry PF00117.10 GATase 216596020658 Pfam match to entry PF00425.7 Chorismate_bind 216596020659 Pfam match to entry PF04715.2 Anth_synt_I_N 216596020660 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 216596020661 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216596020662 N-terminal plug; other site 216596020663 ligand-binding site [chemical binding]; other site 216596020664 Pfam match to entry PF00593.9 TonB_dep_Rec 216596020665 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 216596020666 Pfam match to entry PF06904.1 Extensin-like_C 216596020667 2 probable transmembrane helices predicted at aa 3-22 and 27-49 216596020668 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 216596020669 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 216596020670 Potassium binding sites [ion binding]; other site 216596020671 Cesium cation binding sites [ion binding]; other site 216596020672 Pfam match to entry PF01268.8 FTHFS 216596020673 hypothetical protein; Provisional; Region: PRK05208 216596020674 Pfam match to entry PF03350.3 UPF0114 216596020675 4 probable transmembrane helices predicted at aa 5-27, 37-59, 94-111 and 121-141 216596020676 Predicted periplasmic protein [Function unknown]; Region: COG3904 216596020677 Predicted periplasmic protein [Function unknown]; Region: COG3904 216596020678 1 probable transmembrane helix predicted at aa 13-35 216596020679 Autoinducer binding domain; Region: Autoind_bind; pfam03472 216596020680 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 216596020681 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216596020682 DNA binding residues [nucleotide binding] 216596020683 dimerization interface [polypeptide binding]; other site 216596020684 Pfam match to entry PF00196.8 GerE 216596020685 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 216596020686 PAS fold; Region: PAS_3; pfam08447 216596020687 putative active site [active] 216596020688 heme pocket [chemical binding]; other site 216596020689 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5345 216596020690 2 probable transmembrane helices predicted at aa 19-38 and 43-65 216596020691 thymidine kinase; Provisional; Region: PRK04296 216596020692 Pfam match to entry PF00265.8 TK 216596020693 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 216596020694 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 216596020695 Pfam match to entry PF04069.2 OpuAC 216596020696 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 216596020697 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596020698 dimer interface [polypeptide binding]; other site 216596020699 conserved gate region; other site 216596020700 ABC-ATPase subunit interface; other site 216596020701 7 probable transmembrane helices predicted at aa 7-29, 78-109, 121-143, 167-189,202-224, 244-266 and 273-292 216596020702 Pfam match to entry PF00528.10 BPD_transp_1 216596020703 choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415 216596020704 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216596020705 Walker A/P-loop; other site 216596020706 ATP binding site [chemical binding]; other site 216596020707 Q-loop/lid; other site 216596020708 ABC transporter signature motif; other site 216596020709 Walker B; other site 216596020710 D-loop; other site 216596020711 H-loop/switch region; other site 216596020712 Pfam match to entry PF00005.11 ABC_tran 216596020713 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 216596020714 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 216596020715 Pfam match to entry PF01243.8 Pyridox_oxidase 216596020716 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216596020717 dimerization interface [polypeptide binding]; other site 216596020718 putative DNA binding site [nucleotide binding]; other site 216596020719 putative Zn2+ binding site [ion binding]; other site 216596020720 Pfam match to entry PF01022.8 HTH_5 216596020721 omega amino acid--pyruvate transaminase; Provisional; Region: PRK13360 216596020722 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 216596020723 inhibitor-cofactor binding pocket; inhibition site 216596020724 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596020725 catalytic residue [active] 216596020726 Pfam match to entry PF00202.8 Aminotran_3 216596020727 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 216596020728 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 216596020729 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 216596020730 Zn2+ binding site [ion binding]; other site 216596020731 Mg2+ binding site [ion binding]; other site 216596020732 Pfam match to entry PF01966.8 HD 216596020733 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 216596020734 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 216596020735 dimerization interface [polypeptide binding]; other site 216596020736 ligand binding site [chemical binding]; other site 216596020737 Pfam match to entry PF01094.13 ANF_receptor 216596020738 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 216596020739 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 216596020740 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 216596020741 active site 216596020742 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 216596020743 Pfam match to entry PF01979.7 Amidohydro_1 216596020744 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 216596020745 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 216596020746 active site 216596020747 catalytic site [active] 216596020748 Pfam match to entry PF00128.11 Alpha-amylase 216596020749 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 216596020750 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 216596020751 peptide binding site [polypeptide binding]; other site 216596020752 Pfam match to entry PF00496.8 SBP_bac_5 216596020753 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 216596020754 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596020755 dimer interface [polypeptide binding]; other site 216596020756 conserved gate region; other site 216596020757 putative PBP binding loops; other site 216596020758 ABC-ATPase subunit interface; other site 216596020759 6 probable transmembrane helices predicted at aa 9-31, 100-122, 129-151, 161-183,232-254 and 278-300 216596020760 Pfam match to entry PF00528.10 BPD_transp_1 216596020761 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 216596020762 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 216596020763 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596020764 dimer interface [polypeptide binding]; other site 216596020765 conserved gate region; other site 216596020766 putative PBP binding loops; other site 216596020767 ABC-ATPase subunit interface; other site 216596020768 6 probable transmembrane helices predicted at aa 50-72, 115-137, 150-172, 176-195,226-248 and 280-302 216596020769 Pfam match to entry PF00528.10 BPD_transp_1 216596020770 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 216596020771 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596020772 Walker A/P-loop; other site 216596020773 ATP binding site [chemical binding]; other site 216596020774 Q-loop/lid; other site 216596020775 ABC transporter signature motif; other site 216596020776 Walker B; other site 216596020777 D-loop; other site 216596020778 H-loop/switch region; other site 216596020779 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 216596020780 Pfam match to entry PF00005.11 ABC_tran 216596020781 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 216596020782 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596020783 Walker A/P-loop; other site 216596020784 ATP binding site [chemical binding]; other site 216596020785 Q-loop/lid; other site 216596020786 ABC transporter signature motif; other site 216596020787 Walker B; other site 216596020788 D-loop; other site 216596020789 H-loop/switch region; other site 216596020790 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 216596020791 Pfam match to entry PF00005.11 ABC_tran 216596020792 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 216596020793 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 216596020794 substrate binding site [chemical binding]; other site 216596020795 ATP binding site [chemical binding]; other site 216596020796 Pfam match to entry PF00294.10 PfkB 216596020797 glutamine synthetase; Region: PLN02284 216596020798 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 216596020799 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 216596020800 Pfam match to entry PF03951.4 Gln-synt_N 216596020801 Pfam match to entry PF00120.9 Gln-synt_C 216596020802 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 216596020803 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 216596020804 Pfam match to entry PF00534.8 Glycos_transf_1 216596020805 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 216596020806 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 216596020807 Pfam match to entry PF00135.13 COesterase 216596020808 MarR family; Region: MarR; pfam01047 216596020809 Pfam match to entry PF01047.8 MarR 216596020810 GTP-binding protein Der; Reviewed; Region: PRK00093 216596020811 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 216596020812 G1 box; other site 216596020813 GTP/Mg2+ binding site [chemical binding]; other site 216596020814 Switch I region; other site 216596020815 G2 box; other site 216596020816 Switch II region; other site 216596020817 G3 box; other site 216596020818 G4 box; other site 216596020819 G5 box; other site 216596020820 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 216596020821 G1 box; other site 216596020822 GTP/Mg2+ binding site [chemical binding]; other site 216596020823 Switch I region; other site 216596020824 G2 box; other site 216596020825 G3 box; other site 216596020826 Switch II region; other site 216596020827 G4 box; other site 216596020828 G5 box; other site 216596020829 Pfam match to entry PF01926.7 MMR_HSR1 216596020830 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 216596020831 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 216596020832 1 probable transmembrane helix predicted at aa 27-49 216596020833 NnrU protein; Region: NnrU; pfam07298 216596020834 Pfam match to entry PF07298.1 NnrU 216596020835 5 probable transmembrane helices predicted at aa 2-21, 36-58, 71-93, 127-144 and 165-187 216596020836 Putative catalytic domain of uncharacterized bacterial hypothetical proteins similar to insect chitin deacetylase-like proteins; Region: CE4_CDA_like_3; cd10976 216596020837 NodB motif; other site 216596020838 putative active site [active] 216596020839 putative catalytic site [active] 216596020840 microcin B17 transporter; Reviewed; Region: PRK11098 216596020841 7 probable transmembrane helices predicted at aa 12-34, 61-83, 90-112, 148-170,208-230, 245-267 and 335-357 216596020842 Pfam match to entry PF05992.1 SbmA_BacA 216596020843 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 216596020844 12 probable transmembrane helices predicted at aa 21-43, 66-88, 95-117, 121-143,156-178, 188-210, 231-253, 263-282, 289-311, 321-340,353-375 and 381-403 216596020845 Pfam match to entry PF06779.1 DUF1228 216596020846 Signal peptide predicted for RL3558 by SignalP 2.0 HMM (Signal peptide probabilty 0.821) with cleavage site probability 0.556 between residues 62 and 63 216596020847 Predicted transcriptional regulators [Transcription]; Region: COG1695 216596020848 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 216596020849 Pfam match to entry PF03551.4 PadR 216596020850 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 216596020851 active site 216596020852 Pfam match to entry PF00557.8 Peptidase_M24 216596020853 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 216596020854 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 216596020855 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 216596020856 Pfam match to entry PF00296.10 Bac_luciferase 216596020857 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896 216596020858 putative hydrophobic ligand binding site [chemical binding]; other site 216596020859 Pfam match to entry PF05146.3 DUF704 216596020860 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 216596020861 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216596020862 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 216596020863 Pfam match to entry PF04542.2 Sigma70_r2 216596020864 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 216596020865 Pfam match to entry PF04946.2 DGPF 216596020866 HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401 216596020867 Pfam match to entry PF01966.8 HD 216596020868 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 216596020869 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 216596020870 conserved cys residue [active] 216596020871 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216596020872 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216596020873 Pfam match to entry PF01965.9 DJ-1_PfpI 216596020874 Pfam match to entry PF00165.8 HTH_AraC 216596020875 Pfam match to entry PF00165.8 HTH_AraC 216596020876 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 216596020877 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 216596020878 N- and C-terminal domain interface [polypeptide binding]; other site 216596020879 active site 216596020880 MgATP binding site [chemical binding]; other site 216596020881 catalytic site [active] 216596020882 metal binding site [ion binding]; metal-binding site 216596020883 glycerol binding site [chemical binding]; other site 216596020884 homotetramer interface [polypeptide binding]; other site 216596020885 homodimer interface [polypeptide binding]; other site 216596020886 FBP binding site [chemical binding]; other site 216596020887 protein IIAGlc interface [polypeptide binding]; other site 216596020888 Pfam match to entry PF02782.4 FGGY_C 216596020889 Pfam match to entry PF00370.9 FGGY_N 216596020890 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 216596020891 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 216596020892 NAD binding site [chemical binding]; other site 216596020893 homotetramer interface [polypeptide binding]; other site 216596020894 homodimer interface [polypeptide binding]; other site 216596020895 substrate binding site [chemical binding]; other site 216596020896 active site 216596020897 Pfam match to entry PF00106.11 adh_short 216596020898 Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A [Nucleotide transport and metabolism]; Region: XdhA; COG4630 216596020899 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 216596020900 catalytic loop [active] 216596020901 iron binding site [ion binding]; other site 216596020902 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 216596020903 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 216596020904 Pfam match to entry PF00111.12 Fer2 216596020905 Pfam match to entry PF01799.6 Fer2_2 216596020906 Pfam match to entry PF00941.7 FAD_binding_5 216596020907 Pfam match to entry PF03450.3 CO_deh_flav_C 216596020908 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 216596020909 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 216596020910 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 216596020911 Pfam match to entry PF01315.9 Ald_Xan_dh_C 216596020912 Pfam match to entry PF02738.5 Ald_Xan_dh_C2 216596020913 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 216596020914 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 216596020915 XdhC Rossmann domain; Region: XdhC_C; pfam13478 216596020916 Pfam match to entry PF02625.5 XdhC_CoxI 216596020917 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 216596020918 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596020919 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 216596020920 dimerization interface [polypeptide binding]; other site 216596020921 substrate binding pocket [chemical binding]; other site 216596020922 Pfam match to entry PF00126.10 HTH_1 216596020923 Pfam match to entry PF03466.5 LysR_substrate 216596020924 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 216596020925 conserved cys residue [active] 216596020926 Predicted membrane protein [Function unknown]; Region: COG3748 216596020927 Protein of unknown function (DUF989); Region: DUF989; pfam06181 216596020928 Cytochrome c; Region: Cytochrom_C; pfam00034 216596020929 Pfam match to entry PF06181.1 DUF989 216596020930 7 probable transmembrane helices predicted at aa 13-35, 88-110, 117-139, 149-168,175-197, 249-271 and 283-301 216596020931 guanine deaminase; Provisional; Region: PRK09228 216596020932 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 216596020933 active site 216596020934 Pfam match to entry PF01979.7 Amidohydro_1 216596020935 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 216596020936 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 216596020937 phosphate binding site [ion binding]; other site 216596020938 Pfam match to entry PF01070.7 FMN_dh 216596020939 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 216596020940 Pfam match to entry PF04012.2 PspA_IM30 216596020941 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 216596020942 Pfam match to entry PF07290.1 DUF1449 216596020943 3 probable transmembrane helices predicted at aa 12-34, 54-76 and 89-111 216596020944 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 216596020945 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 216596020946 1 probable transmembrane helix predicted at aa 5-27 216596020947 Pfam match to entry PF01145.11 Band_7 216596020948 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 216596020949 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 216596020950 active site 216596020951 metal binding site [ion binding]; metal-binding site 216596020952 Pfam match to entry PF00149.12 Metallophos 216596020953 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 216596020954 active site 216596020955 homotetramer interface [polypeptide binding]; other site 216596020956 Pfam match to entry PF00576.9 Transthyretin 216596020957 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 216596020958 ureidoglycolate hydrolase; Provisional; Region: PRK03606 216596020959 Pfam match to entry PF04115.2 Ureidogly_hydro 216596020960 Protein of unknown function DUF86; Region: DUF86; cl01031 216596020961 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195 216596020962 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 216596020963 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 216596020964 active site 216596020965 catalytic site [active] 216596020966 tetramer interface [polypeptide binding]; other site 216596020967 Pfam match to entry PF01522.9 Polysacc_deac_1 216596020968 Protein of unknown function (DUF1045); Region: DUF1045; pfam06299 216596020969 Pfam match to entry PF06299.1 DUF1045 216596020970 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 216596020971 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 216596020972 Pfam match to entry PF01266.8 DAO 216596020973 2 probable transmembrane helices predicted at aa 10-32 and 39-61 216596020974 Uncharacterized conserved protein [Function unknown]; Region: COG4121 216596020975 Pfam match to entry PF05430.1 DUF752 216596020976 PAS domain S-box; Region: sensory_box; TIGR00229 216596020977 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216596020978 putative active site [active] 216596020979 heme pocket [chemical binding]; other site 216596020980 PAS domain; Region: PAS; smart00091 216596020981 PAS fold; Region: PAS_7; pfam12860 216596020982 PAS fold; Region: PAS_7; pfam12860 216596020983 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216596020984 dimer interface [polypeptide binding]; other site 216596020985 phosphorylation site [posttranslational modification] 216596020986 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596020987 ATP binding site [chemical binding]; other site 216596020988 Mg2+ binding site [ion binding]; other site 216596020989 G-X-G motif; other site 216596020990 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 216596020991 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596020992 active site 216596020993 phosphorylation site [posttranslational modification] 216596020994 intermolecular recognition site; other site 216596020995 dimerization interface [polypeptide binding]; other site 216596020996 Response regulator receiver domain; Region: Response_reg; pfam00072 216596020997 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596020998 active site 216596020999 phosphorylation site [posttranslational modification] 216596021000 intermolecular recognition site; other site 216596021001 dimerization interface [polypeptide binding]; other site 216596021002 Pfam match to entry PF00072.9 Response_reg 216596021003 Pfam match to entry PF00072.9 Response_reg 216596021004 Pfam match to entry PF02518.9 HATPase_c 216596021005 Pfam match to entry PF00512.10 HisKA 216596021006 Pfam match to entry PF00989.11 PAS 216596021007 Pfam match to entry PF00989.11 PAS 216596021008 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596021009 benzoate transport; Region: 2A0115; TIGR00895 216596021010 putative substrate translocation pore; other site 216596021011 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596021012 Pfam match to entry PF00083.9 Sugar_tr 216596021013 11 probable transmembrane helices predicted at aa 40-62, 72-94, 101-123, 127-149,162-184, 188-210, 273-295, 308-330, 337-359, 364-386 and 428-450 216596021014 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 216596021015 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 216596021016 inhibitor site; inhibition site 216596021017 active site 216596021018 dimer interface [polypeptide binding]; other site 216596021019 catalytic residue [active] 216596021020 Pfam match to entry PF00701.10 DHDPS 216596021021 Transcriptional regulators [Transcription]; Region: PurR; COG1609 216596021022 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216596021023 DNA binding site [nucleotide binding] 216596021024 domain linker motif; other site 216596021025 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 216596021026 Pfam match to entry PF00356.8 LacI 216596021027 Pfam match to entry PF00532.8 Peripla_BP_1 216596021028 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 216596021029 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 216596021030 DEAD-like helicases superfamily; Region: DEXDc; smart00487 216596021031 ATP binding site [chemical binding]; other site 216596021032 Mg++ binding site [ion binding]; other site 216596021033 motif III; other site 216596021034 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216596021035 nucleotide binding region [chemical binding]; other site 216596021036 ATP-binding site [chemical binding]; other site 216596021037 Pfam match to entry PF00270.12 DEAD 216596021038 Pfam match to entry PF00271.13 Helicase_C 216596021039 sensor protein RstB; Provisional; Region: PRK10604 216596021040 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596021041 ATP binding site [chemical binding]; other site 216596021042 Mg2+ binding site [ion binding]; other site 216596021043 G-X-G motif; other site 216596021044 Pfam match to entry PF02518.9 HATPase_c 216596021045 Pfam match to entry PF00672.10 HAMP 216596021046 2 probable transmembrane helices predicted at aa 4-21 and 144-166 216596021047 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 216596021048 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596021049 active site 216596021050 phosphorylation site [posttranslational modification] 216596021051 intermolecular recognition site; other site 216596021052 dimerization interface [polypeptide binding]; other site 216596021053 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216596021054 DNA binding site [nucleotide binding] 216596021055 Pfam match to entry PF00486.11 Trans_reg_C 216596021056 Pfam match to entry PF00072.9 Response_reg 216596021057 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 216596021058 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 216596021059 3 probable transmembrane helices predicted at aa 7-29, 77-99 and 141-163 216596021060 Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839 216596021061 1 probable transmembrane helix predicted at aa 13-35 216596021062 Pfam match to entry PF00839.7 Cys_rich_FGFR 216596021063 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 216596021064 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 216596021065 HlyD family secretion protein; Region: HlyD_3; pfam13437 216596021066 Pfam match to entry PF00529.8 HlyD 216596021067 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 216596021068 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 216596021069 4 probable transmembrane helices predicted at aa 13-35, 271-293, 313-335 and 355-374 216596021070 Pfam match to entry PF02687.7 FtsX 216596021071 Bacterial SH3 domain; Region: SH3_3; cl17532 216596021072 3 probable transmembrane helices predicted at aa 5-27, 42-64 and 84-106 216596021073 EamA-like transporter family; Region: EamA; pfam00892 216596021074 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 216596021075 Pfam match to entry PF00892.8 DUF6 216596021076 10 probable transmembrane helices predicted at aa 56-75, 85-107, 114-136, 141-163,170-187, 202-221, 234-253, 268-287, 292-314 and 318-337 216596021077 Pfam match to entry PF00892.8 DUF6 216596021078 Uncharacterized conserved protein [Function unknown]; Region: COG2308 216596021079 Pfam match to entry PF04169.2 DUF404 216596021080 Pfam match to entry PF04174.2 DUF407 216596021081 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 216596021082 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 216596021083 Pfam match to entry PF04168.2 DUF403 216596021084 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 216596021085 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 216596021086 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 216596021087 Pfam match to entry PF01841.6 Transglut_core 216596021088 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 216596021089 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596021090 active site 216596021091 phosphorylation site [posttranslational modification] 216596021092 intermolecular recognition site; other site 216596021093 dimerization interface [polypeptide binding]; other site 216596021094 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 216596021095 Zn2+ binding site [ion binding]; other site 216596021096 Mg2+ binding site [ion binding]; other site 216596021097 Pfam match to entry PF00072.9 Response_reg 216596021098 Pfam match to entry PF01966.8 HD 216596021099 dihydroxy-acid dehydratase; Validated; Region: PRK06131 216596021100 Pfam match to entry PF00920.9 ILVD_EDD 216596021101 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 216596021102 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 216596021103 NAD(P) binding site [chemical binding]; other site 216596021104 catalytic residues [active] 216596021105 Pfam match to entry PF00171.9 Aldedh 216596021106 Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802 216596021107 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 216596021108 Pfam match to entry PF06829.1 DUF1238 216596021109 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596021110 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216596021111 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596021112 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216596021113 TM-ABC transporter signature motif; other site 216596021114 Pfam match to entry PF02653.5 BPD_transp_2 216596021115 11 probable transmembrane helices predicted at aa 27-49, 54-76, 83-102, 106-128,135-154, 181-203, 224-243, 248-267, 295-317, 327-349 and 354-376 216596021116 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 216596021117 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 216596021118 Walker A/P-loop; other site 216596021119 ATP binding site [chemical binding]; other site 216596021120 Q-loop/lid; other site 216596021121 ABC transporter signature motif; other site 216596021122 Walker B; other site 216596021123 D-loop; other site 216596021124 H-loop/switch region; other site 216596021125 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 216596021126 Pfam match to entry PF00005.11 ABC_tran 216596021127 Pfam match to entry PF00005.11 ABC_tran 216596021128 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 216596021129 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 216596021130 putative ligand binding site [chemical binding]; other site 216596021131 Pfam match to entry PF00532.8 Peripla_BP_1 216596021132 1 probable transmembrane helix predicted at aa 5-24 216596021133 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596021134 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596021135 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 216596021136 putative dimerization interface [polypeptide binding]; other site 216596021137 Pfam match to entry PF00126.10 HTH_1 216596021138 Pfam match to entry PF03466.5 LysR_substrate 216596021139 Hint domain; Region: Hint_2; pfam13403 216596021140 1 probable transmembrane helix predicted at aa 19-41 216596021141 2 probable transmembrane helices predicted at aa 59-78 and 82-101 216596021142 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 216596021143 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 216596021144 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 216596021145 Pfam match to entry PF01408.8 GFO_IDH_MocA 216596021146 Pfam match to entry PF02894.4 GFO_IDH_MocA_C 216596021147 MarR family; Region: MarR_2; cl17246 216596021148 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 216596021149 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 216596021150 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 216596021151 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 216596021152 putative ligand binding site [chemical binding]; other site 216596021153 Pfam match to entry PF00532.8 Peripla_BP_1 216596021154 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596021155 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216596021156 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596021157 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216596021158 TM-ABC transporter signature motif; other site 216596021159 10 probable transmembrane helices predicted at aa 34-56, 66-85, 92-111, 121-140,145-167, 194-216, 235-257, 280-302, 330-352 and 367-389 216596021160 Pfam match to entry PF02653.5 BPD_transp_2 216596021161 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 216596021162 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 216596021163 Walker A/P-loop; other site 216596021164 ATP binding site [chemical binding]; other site 216596021165 Q-loop/lid; other site 216596021166 ABC transporter signature motif; other site 216596021167 Walker B; other site 216596021168 D-loop; other site 216596021169 H-loop/switch region; other site 216596021170 Pfam match to entry PF00005.11 ABC_tran 216596021171 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 216596021172 Bacterial protein of unknown function (DUF882); Region: Peptidase_M15_2; pfam05951 216596021173 Pfam match to entry PF05951.1 DUF882 216596021174 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 216596021175 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216596021176 NAD(P) binding site [chemical binding]; other site 216596021177 active site 216596021178 Pfam match to entry PF01370.8 Epimerase 216596021179 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 216596021180 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 216596021181 active site 216596021182 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 216596021183 Pfam match to entry PF00535.10 Glycos_transf_2 216596021184 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 216596021185 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 216596021186 active site 216596021187 Methyltransferase domain; Region: Methyltransf_31; pfam13847 216596021188 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596021189 S-adenosylmethionine binding site [chemical binding]; other site 216596021190 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 216596021191 putative active site [active] 216596021192 putative metal binding site [ion binding]; other site 216596021193 Pfam match to entry PF00535.10 Glycos_transf_2 216596021194 Pfam match to entry PF05401.1 NodS 216596021195 Pfam match to entry PF01522.9 Polysacc_deac_1 216596021196 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 216596021197 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 216596021198 active site 216596021199 Pfam match to entry PF00535.10 Glycos_transf_2 216596021200 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 216596021201 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 216596021202 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216596021203 Walker A/P-loop; other site 216596021204 ATP binding site [chemical binding]; other site 216596021205 Q-loop/lid; other site 216596021206 ABC transporter signature motif; other site 216596021207 Walker B; other site 216596021208 D-loop; other site 216596021209 H-loop/switch region; other site 216596021210 Pfam match to entry PF00664.9 ABC_membrane 216596021211 5 probable transmembrane helices predicted at aa 43-65, 95-117, 169-191, 195-217 and 274-296 216596021212 Pfam match to entry PF00005.11 ABC_tran 216596021213 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 216596021214 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 216596021215 active site 216596021216 Pfam match to entry PF00535.10 Glycos_transf_2 216596021217 TfuA-like protein; Region: TfuA; pfam07812 216596021218 Uncharacterized conserved protein [Function unknown]; Region: COG1944 216596021219 YcaO-like family; Region: YcaO; pfam02624 216596021220 Pfam match to entry PF02624.4 YcaO 216596021221 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216596021222 TPR motif; other site 216596021223 binding surface 216596021224 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 216596021225 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216596021226 non-specific DNA binding site [nucleotide binding]; other site 216596021227 salt bridge; other site 216596021228 sequence-specific DNA binding site [nucleotide binding]; other site 216596021229 Pfam match to entry PF01381.9 HTH_3 216596021230 glycosyl transferase, pseudogene; similarity:fasta; with=UniProt:Q93L34_RHILV (EMBL:AF028810); Rhizobium leguminosarum (biovar viciae).; PssV.; length=396; id 98.737; 396 aa overlap; query 1-396; subject 1-396 216596021231 1 probable transmembrane helix predicted at aa 142-164 216596021232 2 probable transmembrane helices predicted at aa 20-42 and 57-79 216596021233 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 216596021234 Pfam match to entry PF00331.9 Glyco_hydro_10 216596021235 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 216596021236 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_7; cd05844 216596021237 putative ADP-binding pocket [chemical binding]; other site 216596021238 Pfam match to entry PF00534.8 Glycos_transf_1 216596021239 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 216596021240 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 216596021241 trimer interface [polypeptide binding]; other site 216596021242 active site 216596021243 CoA binding site [chemical binding]; other site 216596021244 Pfam match to entry PF00132.9 Hexapep 216596021245 Pfam match to entry PF00132.9 Hexapep 216596021246 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 216596021247 colanic acid exporter; Provisional; Region: PRK10459 216596021248 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 216596021249 Pfam match to entry PF01943.7 Polysacc_synt 216596021250 12 probable transmembrane helices predicted at aa 34-56, 61-83, 95-117, 132-149,165-187, 192-214, 307-324, 337-359, 379-401, 405-424,431-450 and 465-487 216596021251 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 216596021252 Pfam match to entry PF04230.3 PS_pyruv_trans 216596021253 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 216596021254 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 216596021255 active site 216596021256 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 216596021257 Pfam match to entry PF00535.10 Glycos_transf_2 216596021258 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 216596021259 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 216596021260 active site 216596021261 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 216596021262 Pfam match to entry PF00535.10 Glycos_transf_2 216596021263 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 216596021264 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 216596021265 active site 216596021266 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 216596021267 Pfam match to entry PF00535.10 Glycos_transf_2 216596021268 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 216596021269 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 216596021270 active site 216596021271 Pfam match to entry PF00535.10 Glycos_transf_2 216596021272 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 216596021273 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 216596021274 active site 216596021275 Pfam match to entry PF00535.10 Glycos_transf_2 216596021276 1 probable transmembrane helix predicted at aa 273-295 216596021277 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 216596021278 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; pfam04101 216596021279 Pfam match to entry PF04101.4 Glyco_tran_28_C 216596021280 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 216596021281 active site 216596021282 catalytic triad [active] 216596021283 oxyanion hole [active] 216596021284 Pfam match to entry PF00657.10 Lipase_GDSL 216596021285 1 probable transmembrane helix predicted at aa 41-63 216596021286 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 216596021287 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 216596021288 HlyD family secretion protein; Region: HlyD_3; pfam13437 216596021289 Pfam match to entry PF00529.8 HlyD 216596021290 1 probable transmembrane helix predicted at aa 12-34 216596021291 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 216596021292 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 216596021293 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 216596021294 Walker A/P-loop; other site 216596021295 ATP binding site [chemical binding]; other site 216596021296 Q-loop/lid; other site 216596021297 ABC transporter signature motif; other site 216596021298 Walker B; other site 216596021299 D-loop; other site 216596021300 H-loop/switch region; other site 216596021301 Pfam match to entry PF00005.11 ABC_tran 216596021302 Pfam match to entry PF00664.9 ABC_membrane 216596021303 3 probable transmembrane helices predicted at aa 21-43, 58-80 and 144-166 216596021304 Right handed beta helix region; Region: Beta_helix; pfam13229 216596021305 autoaggregation protein, pseudogene; similarity:fasta; with=UniProt:Q9F7Z4_RHILT (EMBL:AF265222); Rhizobium leguminosarum (biovar trifolii).; rap1A; Autoaggregation protein Rap1A.; length=232; id 92.241; 232 aa overlap; query 1-230; subject 1-232 216596021306 1 probable transmembrane helix predicted at aa 7-26 216596021307 Chain length determinant protein; Region: Wzz; pfam02706 216596021308 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 216596021309 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 216596021310 P-loop; other site 216596021311 Magnesium ion binding site [ion binding]; other site 216596021312 2 probable transmembrane helices predicted at aa 40-62 and 452-471 216596021313 Pfam match to entry PF02706.5 Wzz 216596021314 1 probable transmembrane helix predicted at aa 12-34 216596021315 polysaccharide export protein Wza; Provisional; Region: PRK15078 216596021316 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 216596021317 SLBB domain; Region: SLBB; pfam10531 216596021318 Pfam match to entry PF02563.5 Poly_export 216596021319 O-Antigen ligase; Region: Wzy_C; pfam04932 216596021320 12 probable transmembrane helices predicted at aa 13-30, 35-57, 64-83, 120-139,152-174, 189-211, 230-252, 257-279, 292-314, 380-402,415-432 and 436-458 216596021321 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 216596021322 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 216596021323 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 216596021324 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 216596021325 Pfam match to entry PF03721.3 UDPG_MGDP_dh_N 216596021326 Pfam match to entry PF00984.8 UDPG_MGDP_dh 216596021327 Pfam match to entry PF03720.3 UDPG_MGDP_dh_C 216596021328 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 216596021329 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 216596021330 active site 216596021331 metal binding site [ion binding]; metal-binding site 216596021332 Pfam match to entry PF00149.12 Metallophos 216596021333 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 216596021334 Pfam match to entry PF02321.6 OEP 216596021335 KTSC domain; Region: KTSC; pfam13619 216596021336 Predicted esterase [General function prediction only]; Region: COG0400 216596021337 Serine hydrolase (FSH1); Region: FSH1; pfam03959 216596021338 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 216596021339 Zn binding site [ion binding]; other site 216596021340 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 216596021341 Zn binding site [ion binding]; other site 216596021342 Pfam match to entry PF00903.11 Glyoxalase 216596021343 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 216596021344 ligand binding site [chemical binding]; other site 216596021345 active site 216596021346 UGI interface [polypeptide binding]; other site 216596021347 catalytic site [active] 216596021348 Pfam match to entry PF03167.6 UDG 216596021349 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 216596021350 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 216596021351 active site 216596021352 substrate binding site [chemical binding]; other site 216596021353 metal binding site [ion binding]; metal-binding site 216596021354 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 216596021355 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 216596021356 Substrate binding site; other site 216596021357 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 216596021358 Pfam match to entry PF02878.5 PGM_PMM_I 216596021359 Pfam match to entry PF02879.5 PGM_PMM_II 216596021360 Pfam match to entry PF02880.5 PGM_PMM_III 216596021361 Pfam match to entry PF00408.9 PGM_PMM_IV 216596021362 Pfam match to entry PF00483.9 NTP_transferase 216596021363 Pfam match to entry PF01050.8 MannoseP_isomer 216596021364 1 probable transmembrane helix predicted at aa 5-27 216596021365 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 216596021366 putative catalytic site [active] 216596021367 putative metal binding site [ion binding]; other site 216596021368 putative phosphate binding site [ion binding]; other site 216596021369 Pfam match to entry PF03372.6 Exo_endo_phos 216596021370 3 probable transmembrane helices predicted at aa 47-69, 73-95 and 102-121 216596021371 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 216596021372 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 216596021373 putative NAD(P) binding site [chemical binding]; other site 216596021374 active site 216596021375 putative substrate binding site [chemical binding]; other site 216596021376 Pfam match to entry PF01370.8 Epimerase 216596021377 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 216596021378 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216596021379 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 216596021380 Pfam match to entry PF00440.8 TetR_N 216596021381 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 216596021382 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 216596021383 HlyD family secretion protein; Region: HlyD_3; pfam13437 216596021384 1 probable transmembrane helix predicted at aa 7-24 216596021385 Pfam match to entry PF00529.8 HlyD 216596021386 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 216596021387 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 216596021388 Walker A/P-loop; other site 216596021389 ATP binding site [chemical binding]; other site 216596021390 Q-loop/lid; other site 216596021391 ABC transporter signature motif; other site 216596021392 Walker B; other site 216596021393 D-loop; other site 216596021394 H-loop/switch region; other site 216596021395 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 216596021396 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216596021397 Walker A/P-loop; other site 216596021398 ATP binding site [chemical binding]; other site 216596021399 Q-loop/lid; other site 216596021400 ABC transporter signature motif; other site 216596021401 Walker B; other site 216596021402 D-loop; other site 216596021403 H-loop/switch region; other site 216596021404 Pfam match to entry PF00005.11 ABC_tran 216596021405 Pfam match to entry PF00005.11 ABC_tran 216596021406 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 216596021407 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 216596021408 6 probable transmembrane helices predicted at aa 27-49, 180-202, 233-255, 259-281,288-310 and 344-366 216596021409 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 216596021410 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 216596021411 5 probable transmembrane helices predicted at aa 176-198, 219-241, 256-278,285-307 and 342-364 216596021412 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 216596021413 2 probable transmembrane helices predicted at aa 5-27 and 37-59 216596021414 Pfam match to entry PF06823.1 DUF1236 216596021415 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 216596021416 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 216596021417 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 216596021418 Pfam match to entry PF02894.4 GFO_IDH_MocA_C 216596021419 Pfam match to entry PF01408.8 GFO_IDH_MocA 216596021420 Trehalose utilization protein [Carbohydrate transport and metabolism]; Region: ThuA; COG4813 216596021421 conserved cys residue [active] 216596021422 Pfam match to entry PF06283.1 DUF1037 216596021423 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 216596021424 4 probable transmembrane helices predicted at aa 7-26, 30-52, 59-81 and 86-108 216596021425 Pfam match to entry PF00893.7 Multi_Drug_Res 216596021426 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216596021427 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216596021428 Pfam match to entry PF00440.8 TetR_N 216596021429 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 216596021430 apolar tunnel; other site 216596021431 heme binding site [chemical binding]; other site 216596021432 dimerization interface [polypeptide binding]; other site 216596021433 Pfam match to entry PF01152.8 Bac_globin 216596021434 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 216596021435 4 probable transmembrane helices predicted at aa 9-31, 36-58, 65-87 and 97-119 216596021436 Pfam match to entry PF04241.4 DUF423 216596021437 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 216596021438 Pfam match to entry PF03992.3 ABM 216596021439 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 216596021440 Codons 235 to the C-terminus are similar to Pasteurella multocida TonB protein. UniProt:TONB_PASMU (EMBL:AF070473) (256 aa), and similar, although possibly truncated at the N-terminus, to Rhizobium leguminosarum TonB protein. UniProt:Q9AE36_RHILE (EMBL:RLE310723) (454 aa). This CDS may be a frameshifted pseudogene, alternatively the start site may be at codon 14; similarity:fasta; with=UniProt:TONB_PASMU (EMBL:AF070473); Pasteurella multocida.; TonB protein.; length=256; id 31.905; 210 aa overlap; query 248-450; subject 55-251; similarity:fasta; with=UniProt:Q9AE36_RHILE (EMBL:RLE310723); Rhizobium leguminosarum.; TonB protein.; length=454; id 59.300; 457 aa overlap; query 1-442; subject 1-441; TonB receptor protein, pseudogene 216596021441 1 probable transmembrane helix predicted at aa 96-118 216596021442 Hemin uptake protein hemP; Region: hemP; pfam10636 216596021443 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 216596021444 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 216596021445 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 216596021446 Pfam match to entry PF05171.2 HemS 216596021447 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 216596021448 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 216596021449 putative hemin binding site; other site 216596021450 1 probable transmembrane helix predicted at aa 13-32 216596021451 Pfam match to entry PF01497.7 Peripla_BP_2 216596021452 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 216596021453 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 216596021454 ABC-ATPase subunit interface; other site 216596021455 dimer interface [polypeptide binding]; other site 216596021456 putative PBP binding regions; other site 216596021457 10 probable transmembrane helices predicted at aa 30-52, 90-112, 119-141, 151-173,185-207, 222-244, 251-268, 278-300, 313-335 and 345-362 216596021458 Pfam match to entry PF01032.7 FecCD 216596021459 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 216596021460 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 216596021461 Walker A/P-loop; other site 216596021462 ATP binding site [chemical binding]; other site 216596021463 Q-loop/lid; other site 216596021464 ABC transporter signature motif; other site 216596021465 Walker B; other site 216596021466 D-loop; other site 216596021467 H-loop/switch region; other site 216596021468 Pfam match to entry PF00005.11 ABC_tran 216596021469 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 216596021470 Pfam match to entry PF05957.1 DUF883 216596021471 1 probable transmembrane helix predicted at aa 105-122 216596021472 3 probable transmembrane helices predicted at aa 27-49, 59-81 and 102-124 216596021473 RNA polymerase sigma factor; Provisional; Region: PRK12516 216596021474 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216596021475 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 216596021476 DNA binding residues [nucleotide binding] 216596021477 Pfam match to entry PF04545.3 Sigma70_r4 216596021478 Pfam match to entry PF04542.2 Sigma70_r2 216596021479 two-component response regulator; Provisional; Region: PRK09191 216596021480 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 216596021481 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596021482 active site 216596021483 phosphorylation site [posttranslational modification] 216596021484 intermolecular recognition site; other site 216596021485 dimerization interface [polypeptide binding]; other site 216596021486 Pfam match to entry PF00072.9 Response_reg 216596021487 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 216596021488 HWE histidine kinase; Region: HWE_HK; pfam07536 216596021489 Pfam match to entry PF07536.2 HWE_HK 216596021490 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 216596021491 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 216596021492 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 216596021493 Pfam match to entry PF00070.12 Pyr_redox 216596021494 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 216596021495 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 216596021496 homodimer interface [polypeptide binding]; other site 216596021497 active site 216596021498 FMN binding site [chemical binding]; other site 216596021499 substrate binding site [chemical binding]; other site 216596021500 4Fe-4S binding domain; Region: Fer4_6; pfam12837 216596021501 4Fe-4S binding domain; Region: Fer4; pfam00037 216596021502 Pfam match to entry PF01180.11 DHO_dh 216596021503 Pfam match to entry PF00037.11 Fer4 216596021504 Pfam match to entry PF00037.11 Fer4 216596021505 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 216596021506 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 216596021507 conserved cys residue [active] 216596021508 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216596021509 Pfam match to entry PF00165.8 HTH_AraC 216596021510 Pfam match to entry PF00165.8 HTH_AraC 216596021511 Pfam match to entry PF01965.9 DJ-1_PfpI 216596021512 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 216596021513 active site residue [active] 216596021514 Pfam match to entry PF00581.7 Rhodanese 216596021515 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 216596021516 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 216596021517 putative NAD(P) binding site [chemical binding]; other site 216596021518 Pfam match to entry PF00107.10 ADH_zinc_N 216596021519 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596021520 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596021521 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 216596021522 putative effector binding pocket; other site 216596021523 putative dimerization interface [polypeptide binding]; other site 216596021524 Pfam match to entry PF00126.10 HTH_1 216596021525 Pfam match to entry PF03466.5 LysR_substrate 216596021526 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 216596021527 heme binding pocket [chemical binding]; other site 216596021528 heme ligand [chemical binding]; other site 216596021529 Pfam match to entry PF01126.9 Heme_oxygenase 216596021530 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 216596021531 GAF domain; Region: GAF; pfam01590 216596021532 Phytochrome region; Region: PHY; pfam00360 216596021533 HWE histidine kinase; Region: HWE_HK; pfam07536 216596021534 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596021535 active site 216596021536 phosphorylation site [posttranslational modification] 216596021537 intermolecular recognition site; other site 216596021538 dimerization interface [polypeptide binding]; other site 216596021539 Pfam match to entry PF01590.11 GAF 216596021540 Pfam match to entry PF00360.9 Phytochrome 216596021541 Pfam match to entry PF07536.2 HWE_HK 216596021542 Pfam match to entry PF00072.9 Response_reg 216596021543 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 216596021544 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216596021545 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 216596021546 Pfam match to entry PF00440.8 TetR_N 216596021547 allantoate amidohydrolase; Reviewed; Region: PRK12893 216596021548 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 216596021549 active site 216596021550 metal binding site [ion binding]; metal-binding site 216596021551 dimer interface [polypeptide binding]; other site 216596021552 Pfam match to entry PF01546.12 Peptidase_M20 216596021553 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 216596021554 putative active site [active] 216596021555 Pfam match to entry PF04480.2 DUF559 216596021556 phenylhydantoinase; Validated; Region: PRK08323 216596021557 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 216596021558 tetramer interface [polypeptide binding]; other site 216596021559 active site 216596021560 Pfam match to entry PF01979.7 Amidohydro_1 216596021561 Cupin domain; Region: Cupin_2; cl17218 216596021562 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 216596021563 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 216596021564 Walker A/P-loop; other site 216596021565 ATP binding site [chemical binding]; other site 216596021566 Q-loop/lid; other site 216596021567 ABC transporter signature motif; other site 216596021568 Walker B; other site 216596021569 D-loop; other site 216596021570 H-loop/switch region; other site 216596021571 Pfam match to entry PF00005.11 ABC_tran 216596021572 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 216596021573 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596021574 dimer interface [polypeptide binding]; other site 216596021575 conserved gate region; other site 216596021576 putative PBP binding loops; other site 216596021577 ABC-ATPase subunit interface; other site 216596021578 5 probable transmembrane helices predicted at aa 10-32, 96-118, 133-155, 238-260 and 275-297 216596021579 Pfam match to entry PF00528.10 BPD_transp_1 216596021580 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 216596021581 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596021582 dimer interface [polypeptide binding]; other site 216596021583 conserved gate region; other site 216596021584 putative PBP binding loops; other site 216596021585 ABC-ATPase subunit interface; other site 216596021586 11 probable transmembrane helices predicted at aa 5-27, 34-56, 60-82, 89-108,123-145, 152-174, 179-201, 213-235, 245-267, 302-324 and 339-361 216596021587 Pfam match to entry PF00528.10 BPD_transp_1 216596021588 NMT1/THI5 like; Region: NMT1; pfam09084 216596021589 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 216596021590 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 216596021591 HlyD family secretion protein; Region: HlyD_3; pfam13437 216596021592 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 216596021593 ABC-2 type transporter; Region: ABC2_membrane; cl17235 216596021594 Pfam match to entry PF00873.7 ACR_tran 216596021595 12 probable transmembrane helices predicted at aa 12-34, 332-351, 358-377, 387-409,430-452, 457-479, 519-541, 876-895, 902-921, 931-953,974-996 and 1006-1028 216596021596 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 216596021597 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 216596021598 ligand binding site [chemical binding]; other site 216596021599 flexible hinge region; other site 216596021600 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 216596021601 putative switch regulator; other site 216596021602 non-specific DNA interactions [nucleotide binding]; other site 216596021603 DNA binding site [nucleotide binding] 216596021604 sequence specific DNA binding site [nucleotide binding]; other site 216596021605 putative cAMP binding site [chemical binding]; other site 216596021606 Pfam match to entry PF00027.13 cNMP_binding 216596021607 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 216596021608 Pfam match to entry PF01495.7 HypB_UreG 216596021609 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 216596021610 UreF; Region: UreF; pfam01730 216596021611 Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371 216596021612 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cl03727 216596021613 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 216596021614 dimer interface [polypeptide binding]; other site 216596021615 catalytic residues [active] 216596021616 Pfam match to entry PF05194.2 UreE_C 216596021617 Pfam match to entry PF02814.5 UreE_N 216596021618 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 216596021619 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216596021620 metal binding site [ion binding]; metal-binding site 216596021621 active site 216596021622 I-site; other site 216596021623 Pfam match to entry PF00990.8 GGDEF 216596021624 2 probable transmembrane helices predicted at aa 23-45 and 65-87 216596021625 Protein of unknown function (DUF2459); Region: DUF2459; cl09819 216596021626 1 probable transmembrane helix predicted at aa 7-26 216596021627 urease subunit alpha; Reviewed; Region: ureC; PRK13207 216596021628 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 216596021629 subunit interactions [polypeptide binding]; other site 216596021630 active site 216596021631 flap region; other site 216596021632 Pfam match to entry PF01979.7 Amidohydro_1 216596021633 Pfam match to entry PF00449.9 Urease_alpha 216596021634 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 216596021635 Pfam match to entry PF07007.1 DUF1311 216596021636 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 216596021637 gamma-beta subunit interface [polypeptide binding]; other site 216596021638 alpha-beta subunit interface [polypeptide binding]; other site 216596021639 Pfam match to entry PF00699.8 Urease_beta 216596021640 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 216596021641 alpha-gamma subunit interface [polypeptide binding]; other site 216596021642 beta-gamma subunit interface [polypeptide binding]; other site 216596021643 Pfam match to entry PF00547.7 Urease_gamma 216596021644 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 216596021645 Pfam match to entry PF01774.6 UreD 216596021646 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 216596021647 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 216596021648 Walker A/P-loop; other site 216596021649 ATP binding site [chemical binding]; other site 216596021650 Q-loop/lid; other site 216596021651 ABC transporter signature motif; other site 216596021652 Walker B; other site 216596021653 D-loop; other site 216596021654 H-loop/switch region; other site 216596021655 Pfam match to entry PF00005.11 ABC_tran 216596021656 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 216596021657 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 216596021658 Walker A/P-loop; other site 216596021659 ATP binding site [chemical binding]; other site 216596021660 Q-loop/lid; other site 216596021661 ABC transporter signature motif; other site 216596021662 Walker B; other site 216596021663 D-loop; other site 216596021664 H-loop/switch region; other site 216596021665 Pfam match to entry PF00005.11 ABC_tran 216596021666 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 216596021667 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 216596021668 TM-ABC transporter signature motif; other site 216596021669 9 probable transmembrane helices predicted at aa 13-35, 45-64, 66-88, 130-152,159-178, 207-229, 259-281, 296-318 and 325-347 216596021670 Pfam match to entry PF02653.5 BPD_transp_2 216596021671 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 216596021672 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596021673 TM-ABC transporter signature motif; other site 216596021674 9 probable transmembrane helices predicted at aa 7-29, 257-279, 281-303, 318-337,344-366, 395-417, 443-465, 485-507 and 514-533 216596021675 Pfam match to entry PF02653.5 BPD_transp_2 216596021676 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 216596021677 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 216596021678 putative ligand binding site [chemical binding]; other site 216596021679 1 probable transmembrane helix predicted at aa 7-29 216596021680 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 216596021681 active site 216596021682 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 216596021683 autotransporter-associated beta strand repeat; Region: autotrns_rpt; TIGR02601 216596021684 Pfam match to entry PF01569.9 PAP2 216596021685 Na binding site [ion binding]; other site 216596021686 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 216596021687 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 216596021688 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216596021689 dimer interface [polypeptide binding]; other site 216596021690 phosphorylation site [posttranslational modification] 216596021691 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596021692 ATP binding site [chemical binding]; other site 216596021693 Mg2+ binding site [ion binding]; other site 216596021694 G-X-G motif; other site 216596021695 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 216596021696 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596021697 active site 216596021698 phosphorylation site [posttranslational modification] 216596021699 intermolecular recognition site; other site 216596021700 dimerization interface [polypeptide binding]; other site 216596021701 13 probable transmembrane helices predicted at aa 57-79, 84-106, 121-143, 150-172,187-209, 279-301, 321-343, 375-397, 402-421, 442-464,468-490, 584-606 and 621-643 216596021702 Pfam match to entry PF00512.10 HisKA 216596021703 Pfam match to entry PF02518.9 HATPase_c 216596021704 Pfam match to entry PF00072.9 Response_reg 216596021705 Response regulator receiver domain; Region: Response_reg; pfam00072 216596021706 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596021707 active site 216596021708 phosphorylation site [posttranslational modification] 216596021709 intermolecular recognition site; other site 216596021710 dimerization interface [polypeptide binding]; other site 216596021711 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 216596021712 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216596021713 DNA binding residues [nucleotide binding] 216596021714 dimerization interface [polypeptide binding]; other site 216596021715 Pfam match to entry PF00072.9 Response_reg 216596021716 Pfam match to entry PF00196.8 GerE 216596021717 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 216596021718 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 216596021719 dimerization interface [polypeptide binding]; other site 216596021720 ligand binding site [chemical binding]; other site 216596021721 Pfam match to entry PF01094.13 ANF_receptor 216596021722 3 probable transmembrane helices predicted at aa 10-29, 42-64 and 69-91 216596021723 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 216596021724 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 216596021725 Walker A/P-loop; other site 216596021726 ATP binding site [chemical binding]; other site 216596021727 Q-loop/lid; other site 216596021728 ABC transporter signature motif; other site 216596021729 Walker B; other site 216596021730 D-loop; other site 216596021731 H-loop/switch region; other site 216596021732 Pfam match to entry PF00005.11 ABC_tran 216596021733 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 216596021734 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 216596021735 Walker A/P-loop; other site 216596021736 ATP binding site [chemical binding]; other site 216596021737 Q-loop/lid; other site 216596021738 ABC transporter signature motif; other site 216596021739 Walker B; other site 216596021740 D-loop; other site 216596021741 H-loop/switch region; other site 216596021742 Pfam match to entry PF00005.11 ABC_tran 216596021743 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 216596021744 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 216596021745 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 216596021746 TM-ABC transporter signature motif; other site 216596021747 11 probable transmembrane helices predicted at aa 21-40, 55-77, 106-125, 140-162,167-184, 188-210, 217-234, 277-299, 334-356, 371-393 and 414-432 216596021748 Pfam match to entry PF02653.5 BPD_transp_2 216596021749 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596021750 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 216596021751 TM-ABC transporter signature motif; other site 216596021752 8 probable transmembrane helices predicted at aa 15-37, 42-61, 66-88, 100-122,145-167, 197-219, 234-256 and 263-285 216596021753 Pfam match to entry PF02653.5 BPD_transp_2 216596021754 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 216596021755 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 216596021756 active site 216596021757 Pfam match to entry PF00459.10 Inositol_P 216596021758 Bacterial sugar transferase; Region: Bac_transf; pfam02397 216596021759 Pfam match to entry PF02397.6 Bac_transf 216596021760 1 probable transmembrane helix predicted at aa 74-95 216596021761 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 216596021762 Pfam match to entry PF06627.1 DUF1153 216596021763 Paraquat-inducible protein A; Region: PqiA; pfam04403 216596021764 Pfam match to entry PF04403.2 PqiA 216596021765 2 probable transmembrane helices predicted at aa 33-55 and 75-97 216596021766 Predicted acetyltransferase [General function prediction only]; Region: COG2388 216596021767 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 216596021768 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596021769 active site 216596021770 phosphorylation site [posttranslational modification] 216596021771 intermolecular recognition site; other site 216596021772 dimerization interface [polypeptide binding]; other site 216596021773 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216596021774 DNA binding site [nucleotide binding] 216596021775 Pfam match to entry PF00072.9 Response_reg 216596021776 Pfam match to entry PF00486.11 Trans_reg_C 216596021777 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596021778 Response regulator receiver domain; Region: Response_reg; pfam00072 216596021779 active site 216596021780 phosphorylation site [posttranslational modification] 216596021781 intermolecular recognition site; other site 216596021782 dimerization interface [polypeptide binding]; other site 216596021783 Pfam match to entry PF00072.9 Response_reg 216596021784 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5385 216596021785 Protein of unknown function (DUF1134); Region: DUF1134; pfam06577 216596021786 Pfam match to entry PF06577.1 DUF1134 216596021787 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 216596021788 1 probable transmembrane helix predicted at aa 5-27 216596021789 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 216596021790 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 216596021791 Pfam match to entry PF00588.7 SpoU_methylase 216596021792 1 probable transmembrane helix predicted at aa 51-70 216596021793 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 216596021794 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 216596021795 RNA binding surface [nucleotide binding]; other site 216596021796 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 216596021797 active site 216596021798 Pfam match to entry PF01479.9 S4 216596021799 Pfam match to entry PF00849.9 PseudoU_synth_2 216596021800 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 216596021801 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 216596021802 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216596021803 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 216596021804 DNA binding residues [nucleotide binding] 216596021805 Pfam match to entry PF04542.2 Sigma70_r2 216596021806 Pfam match to entry PF04545.3 Sigma70_r4 216596021807 1 probable transmembrane helix predicted at aa 486-508 216596021808 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 216596021809 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 216596021810 GDP-binding site [chemical binding]; other site 216596021811 ACT binding site; other site 216596021812 IMP binding site; other site 216596021813 Pfam match to entry PF00709.9 Adenylsucc_synt 216596021814 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 216596021815 EamA-like transporter family; Region: EamA; pfam00892 216596021816 EamA-like transporter family; Region: EamA; pfam00892 216596021817 10 probable transmembrane helices predicted at aa 5-27, 37-55, 68-85, 90-112,119-141, 156-174, 181-203, 213-235, 248-265 and 269-286 216596021818 Pfam match to entry PF00892.8 DUF6 216596021819 Pfam match to entry PF00892.8 DUF6 216596021820 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216596021821 Coenzyme A binding pocket [chemical binding]; other site 216596021822 Pfam match to entry PF00583.9 Acetyltransf_1 216596021823 PAS fold; Region: PAS_3; pfam08447 216596021824 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 216596021825 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216596021826 metal binding site [ion binding]; metal-binding site 216596021827 active site 216596021828 I-site; other site 216596021829 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216596021830 Pfam match to entry PF00563.9 EAL 216596021831 Pfam match to entry PF00990.8 GGDEF 216596021832 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 216596021833 Pfam match to entry PF00920.9 ILVD_EDD 216596021834 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 216596021835 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 216596021836 Pfam match to entry PF03446.3 NAD_binding_2 216596021837 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 216596021838 Pfam match to entry PF00873.7 ACR_tran 216596021839 12 probable transmembrane helices predicted at aa 38-60, 369-388, 395-417, 422-444,465-487, 502-524, 577-599, 901-923, 928-950, 960-982,1003-1025 and 1040-1062 216596021840 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 216596021841 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 216596021842 HlyD family secretion protein; Region: HlyD_3; pfam13437 216596021843 Pfam match to entry PF00529.8 HlyD 216596021844 1 probable transmembrane helix predicted at aa 7-29 216596021845 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 216596021846 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596021847 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596021848 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 216596021849 putative effector binding pocket; other site 216596021850 putative dimerization interface [polypeptide binding]; other site 216596021851 Pfam match to entry PF00126.10 HTH_1 216596021852 Pfam match to entry PF03466.5 LysR_substrate 216596021853 short chain dehydrogenase; Provisional; Region: PRK12937 216596021854 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 216596021855 NADP binding site [chemical binding]; other site 216596021856 active site 216596021857 steroid binding site; other site 216596021858 Pfam match to entry PF00106.11 adh_short 216596021859 short chain dehydrogenase; Provisional; Region: PRK12939 216596021860 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 216596021861 NADP binding site [chemical binding]; other site 216596021862 homodimer interface [polypeptide binding]; other site 216596021863 active site 216596021864 substrate binding site [chemical binding]; other site 216596021865 Pfam match to entry PF00106.11 adh_short 216596021866 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596021867 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596021868 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 216596021869 putative effector binding pocket; other site 216596021870 putative dimerization interface [polypeptide binding]; other site 216596021871 Pfam match to entry PF00126.10 HTH_1 216596021872 Pfam match to entry PF03466.5 LysR_substrate 216596021873 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 216596021874 active site 216596021875 DNA binding site [nucleotide binding] 216596021876 Pfam match to entry PF02245.5 Pur_DNA_glyco 216596021877 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596021878 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 216596021879 putative substrate translocation pore; other site 216596021880 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596021881 14 probable transmembrane helices predicted at aa 4-21, 42-64, 79-101, 108-130,134-156, 168-190, 195-217, 224-246, 261-283, 296-318,328-350, 362-379, 394-416 and 505-522 216596021882 Pfam match to entry PF00083.9 Sugar_tr 216596021883 Signal peptide predicted for RL3783 by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.782 between residues 31 and 32 216596021884 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 216596021885 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 216596021886 HlyD family secretion protein; Region: HlyD_3; pfam13437 216596021887 Pfam match to entry PF00529.8 HlyD 216596021888 1 probable transmembrane helix predicted at aa 71-88 216596021889 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 216596021890 MarR family; Region: MarR; pfam01047 216596021891 Pfam match to entry PF01047.8 MarR 216596021892 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 216596021893 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 216596021894 HlyD family secretion protein; Region: HlyD_3; pfam13437 216596021895 Pfam match to entry PF00529.8 HlyD 216596021896 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 216596021897 Pfam match to entry PF00873.7 ACR_tran 216596021898 12 probable transmembrane helices predicted at aa 12-34, 343-362, 369-391, 397-419,440-462, 477-499, 541-563, 882-899, 904-926, 936-958,979-1001 and 1016-1038 216596021899 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 216596021900 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 216596021901 active site 216596021902 metal binding site [ion binding]; metal-binding site 216596021903 Pfam match to entry PF00149.12 Metallophos 216596021904 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 216596021905 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216596021906 active site 216596021907 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216596021908 active site 216596021909 Predicted transcriptional regulator [Transcription]; Region: COG1959 216596021910 Transcriptional regulator; Region: Rrf2; pfam02082 216596021911 Pfam match to entry PF02082.5 Rrf2 216596021912 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216596021913 NAD(P) binding site [chemical binding]; other site 216596021914 active site 216596021915 Pfam match to entry PF00106.11 adh_short 216596021916 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 216596021917 Pfam match to entry PF01261.10 AP_endonuc_2 216596021918 Transcriptional regulators [Transcription]; Region: PurR; COG1609 216596021919 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216596021920 DNA binding site [nucleotide binding] 216596021921 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 216596021922 ligand binding site [chemical binding]; other site 216596021923 dimerization interface [polypeptide binding]; other site 216596021924 Pfam match to entry PF00532.8 Peripla_BP_1 216596021925 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 216596021926 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 216596021927 Pfam match to entry PF00496.8 SBP_bac_5 216596021928 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 216596021929 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 216596021930 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 216596021931 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596021932 dimer interface [polypeptide binding]; other site 216596021933 conserved gate region; other site 216596021934 putative PBP binding loops; other site 216596021935 ABC-ATPase subunit interface; other site 216596021936 6 probable transmembrane helices predicted at aa 9-31, 106-128, 141-163, 192-214,253-275 and 299-321 216596021937 Pfam match to entry PF00528.10 BPD_transp_1 216596021938 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 216596021939 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 216596021940 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596021941 dimer interface [polypeptide binding]; other site 216596021942 conserved gate region; other site 216596021943 putative PBP binding loops; other site 216596021944 ABC-ATPase subunit interface; other site 216596021945 7 probable transmembrane helices predicted at aa 52-74, 197-219, 226-248, 253-272,306-328, 332-350 and 362-384 216596021946 Pfam match to entry PF00528.10 BPD_transp_1 216596021947 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 216596021948 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596021949 Walker A/P-loop; other site 216596021950 ATP binding site [chemical binding]; other site 216596021951 Q-loop/lid; other site 216596021952 ABC transporter signature motif; other site 216596021953 Walker B; other site 216596021954 D-loop; other site 216596021955 H-loop/switch region; other site 216596021956 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216596021957 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596021958 Walker A/P-loop; other site 216596021959 ATP binding site [chemical binding]; other site 216596021960 Q-loop/lid; other site 216596021961 ABC transporter signature motif; other site 216596021962 Walker B; other site 216596021963 D-loop; other site 216596021964 H-loop/switch region; other site 216596021965 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216596021966 Pfam match to entry PF00005.11 ABC_tran 216596021967 Pfam match to entry PF00005.11 ABC_tran 216596021968 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 216596021969 Pfam match to entry PF01261.10 AP_endonuc_2 216596021970 tartronate semialdehyde reductase; Provisional; Region: PRK15059 216596021971 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 216596021972 Pfam match to entry PF03446.3 NAD_binding_2 216596021973 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 216596021974 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 216596021975 Pfam match to entry PF02449.5 Glyco_hydro_42 216596021976 1 probable transmembrane helix predicted at aa 139-156 216596021977 Cupin domain; Region: Cupin_2; cl17218 216596021978 Pfam match to entry PF00190.9 Cupin 216596021979 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 216596021980 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 216596021981 Walker A/P-loop; other site 216596021982 ATP binding site [chemical binding]; other site 216596021983 Q-loop/lid; other site 216596021984 ABC transporter signature motif; other site 216596021985 Walker B; other site 216596021986 D-loop; other site 216596021987 H-loop/switch region; other site 216596021988 Pfam match to entry PF03459.4 TOBE 216596021989 Pfam match to entry PF00005.11 ABC_tran 216596021990 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216596021991 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596021992 dimer interface [polypeptide binding]; other site 216596021993 conserved gate region; other site 216596021994 putative PBP binding loops; other site 216596021995 ABC-ATPase subunit interface; other site 216596021996 Pfam match to entry PF00528.10 BPD_transp_1 216596021997 8 probable transmembrane helices predicted at aa 7-29, 76-98, 105-124, 134-156,163-185, 211-233, 238-257 and 272-291 216596021998 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 216596021999 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596022000 putative PBP binding loops; other site 216596022001 dimer interface [polypeptide binding]; other site 216596022002 ABC-ATPase subunit interface; other site 216596022003 Pfam match to entry PF00528.10 BPD_transp_1 216596022004 6 probable transmembrane helices predicted at aa 7-29, 74-96, 108-130, 158-180,201-223 and 265-287 216596022005 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 216596022006 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 216596022007 Pfam match to entry PF01547.11 SBP_bac_1 216596022008 1 probable transmembrane helix predicted at aa 5-24 216596022009 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 216596022010 non-specific DNA interactions [nucleotide binding]; other site 216596022011 DNA binding site [nucleotide binding] 216596022012 sequence specific DNA binding site [nucleotide binding]; other site 216596022013 putative cAMP binding site [chemical binding]; other site 216596022014 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 216596022015 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 216596022016 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 216596022017 Pfam match to entry PF00480.8 ROK 216596022018 Signal peptide predicted for RL3809 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.992 between residues 35 and 36 216596022019 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 216596022020 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 216596022021 Pfam match to entry PF01547.11 SBP_bac_1 216596022022 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596022023 dimer interface [polypeptide binding]; other site 216596022024 conserved gate region; other site 216596022025 putative PBP binding loops; other site 216596022026 ABC-ATPase subunit interface; other site 216596022027 6 probable transmembrane helices predicted at aa 13-35, 71-93, 106-125, 156-178,199-221 and 264-286 216596022028 Pfam match to entry PF00528.10 BPD_transp_1 216596022029 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216596022030 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596022031 dimer interface [polypeptide binding]; other site 216596022032 conserved gate region; other site 216596022033 putative PBP binding loops; other site 216596022034 ABC-ATPase subunit interface; other site 216596022035 6 probable transmembrane helices predicted at aa 10-32, 80-102, 112-134, 139-161,190-212 and 245-267 216596022036 Pfam match to entry PF00528.10 BPD_transp_1 216596022037 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 216596022038 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 216596022039 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 216596022040 Pfam match to entry PF01380.9 SIS 216596022041 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 216596022042 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 216596022043 substrate binding site [chemical binding]; other site 216596022044 ATP binding site [chemical binding]; other site 216596022045 Pfam match to entry PF00294.10 PfkB 216596022046 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 216596022047 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 216596022048 Walker A/P-loop; other site 216596022049 ATP binding site [chemical binding]; other site 216596022050 Q-loop/lid; other site 216596022051 ABC transporter signature motif; other site 216596022052 Walker B; other site 216596022053 D-loop; other site 216596022054 H-loop/switch region; other site 216596022055 TOBE domain; Region: TOBE_2; pfam08402 216596022056 Pfam match to entry PF00005.11 ABC_tran 216596022057 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 216596022058 active site 216596022059 catalytic residues [active] 216596022060 Pfam match to entry PF00722.9 Glyco_hydro_16 216596022061 1 probable transmembrane helix predicted at aa 50-69 216596022062 colanic acid exporter; Provisional; Region: PRK10459 216596022063 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 216596022064 12 probable transmembrane helices predicted at aa 20-37, 42-64, 77-99, 114-136,157-179, 249-271, 291-313, 323-345, 352-374, 379-398,411-433 and 443-465 216596022065 Pfam match to entry PF01943.7 Polysacc_synt 216596022066 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 216596022067 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 216596022068 putative ADP-binding pocket [chemical binding]; other site 216596022069 Pfam match to entry PF00534.8 Glycos_transf_1 216596022070 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 216596022071 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 216596022072 Pfam match to entry PF00534.8 Glycos_transf_1 216596022073 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 216596022074 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 216596022075 ligand binding site [chemical binding]; other site 216596022076 flexible hinge region; other site 216596022077 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 216596022078 Pfam match to entry PF00027.13 cNMP_binding 216596022079 Bacterial sugar transferase; Region: Bac_transf; pfam02397 216596022080 Pfam match to entry PF02397.6 Bac_transf 216596022081 1 probable transmembrane helix predicted at aa 39-61 216596022082 Chain length determinant protein; Region: Wzz; cl15801 216596022083 AAA domain; Region: AAA_31; pfam13614 216596022084 Pfam match to entry PF02706.5 Wzz 216596022085 3 probable transmembrane helices predicted at aa 12-31, 290-309 and 385-407 216596022086 Pfam match to entry PF00535.10 Glycos_transf_2 216596022087 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 216596022088 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 216596022089 SLBB domain; Region: SLBB; pfam10531 216596022090 1 probable transmembrane helix predicted at aa 7-29 216596022091 Pfam match to entry PF02563.5 Poly_export 216596022092 10 probable transmembrane helices predicted at aa 7-29, 44-66, 86-108, 140-162,169-188, 224-243, 256-278, 298-320, 348-370 and 375-397 216596022093 3 probable transmembrane helices predicted at aa 23-45, 52-74 and 78-100 216596022094 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 216596022095 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 216596022096 active site 216596022097 Pfam match to entry PF01501.8 Glyco_transf_8 216596022098 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 216596022099 active site 216596022100 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 216596022101 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 216596022102 ligand binding site [chemical binding]; other site 216596022103 flexible hinge region; other site 216596022104 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 216596022105 Pfam match to entry PF00027.13 cNMP_binding 216596022106 Bacterial sugar transferase; Region: Bac_transf; pfam02397 216596022107 Pfam match to entry PF02397.6 Bac_transf 216596022108 1 probable transmembrane helix predicted at aa 45-67 216596022109 2 probable transmembrane helices predicted at aa 7-39 and 54-76 216596022110 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 216596022111 Pfam match to entry PF01757.9 Acyl_transf_3 216596022112 7 probable transmembrane helices predicted at aa 74-96, 109-131, 176-198, 203-220,230-252, 264-286 and 337-359 216596022113 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 216596022114 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 216596022115 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 216596022116 Trp docking motif [polypeptide binding]; other site 216596022117 putative active site [active] 216596022118 5 probable transmembrane helices predicted at aa 7-29, 34-51, 56-73, 77-99 and 111-133 216596022119 Pfam match to entry PF01011.9 PQQ 216596022120 Pfam match to entry PF01011.9 PQQ 216596022121 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 216596022122 classical (c) SDRs; Region: SDR_c; cd05233 216596022123 NAD(P) binding site [chemical binding]; other site 216596022124 active site 216596022125 Pfam match to entry PF00106.11 adh_short 216596022126 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 216596022127 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 216596022128 Pfam match to entry PF03734.4 ErfK_YbiS_YhnG 216596022129 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 216596022130 4 probable transmembrane helices predicted at aa 5-27, 46-68, 78-95 and 143-165 216596022131 Pfam match to entry PF04140.3 ICMT 216596022132 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 216596022133 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 216596022134 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 216596022135 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216596022136 NAD(P) binding site [chemical binding]; other site 216596022137 active site 216596022138 Pfam match to entry PF00106.11 adh_short 216596022139 2 probable transmembrane helices predicted at aa 246-268 and 344-366 216596022140 Transcriptional regulators [Transcription]; Region: FadR; COG2186 216596022141 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596022142 DNA-binding site [nucleotide binding]; DNA binding site 216596022143 FCD domain; Region: FCD; pfam07729 216596022144 Pfam match to entry PF00392.9 GntR 216596022145 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 216596022146 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 216596022147 ligand binding site [chemical binding]; other site 216596022148 Pfam match to entry PF00532.8 Peripla_BP_1 216596022149 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 216596022150 extended (e) SDRs; Region: SDR_e; cd08946 216596022151 NAD(P) binding site [chemical binding]; other site 216596022152 active site 216596022153 substrate binding site [chemical binding]; other site 216596022154 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 216596022155 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 216596022156 Walker A/P-loop; other site 216596022157 ATP binding site [chemical binding]; other site 216596022158 Q-loop/lid; other site 216596022159 ABC transporter signature motif; other site 216596022160 Walker B; other site 216596022161 D-loop; other site 216596022162 H-loop/switch region; other site 216596022163 Pfam match to entry PF00005.11 ABC_tran 216596022164 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596022165 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216596022166 TM-ABC transporter signature motif; other site 216596022167 8 probable transmembrane helices predicted at aa 20-42, 55-77, 82-101, 108-130,174-196, 227-249, 264-286 and 298-320 216596022168 Pfam match to entry PF02653.5 BPD_transp_2 216596022169 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 216596022170 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 216596022171 Walker A/P-loop; other site 216596022172 ATP binding site [chemical binding]; other site 216596022173 Q-loop/lid; other site 216596022174 ABC transporter signature motif; other site 216596022175 Walker B; other site 216596022176 D-loop; other site 216596022177 H-loop/switch region; other site 216596022178 TOBE domain; Region: TOBE_2; pfam08402 216596022179 Pfam match to entry PF03459.4 TOBE 216596022180 Pfam match to entry PF00005.11 ABC_tran 216596022181 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216596022182 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596022183 dimer interface [polypeptide binding]; other site 216596022184 conserved gate region; other site 216596022185 putative PBP binding loops; other site 216596022186 ABC-ATPase subunit interface; other site 216596022187 Pfam match to entry PF00528.10 BPD_transp_1 216596022188 6 probable transmembrane helices predicted at aa 13-35, 76-98, 103-125, 140-159,198-220 and 243-265 216596022189 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596022190 dimer interface [polypeptide binding]; other site 216596022191 putative PBP binding loops; other site 216596022192 ABC-ATPase subunit interface; other site 216596022193 Pfam match to entry PF00528.10 BPD_transp_1 216596022194 6 probable transmembrane helices predicted at aa 28-50, 89-111, 118-140, 174-196,217-239 and 275-297 216596022195 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 216596022196 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 216596022197 Pfam match to entry PF01547.11 SBP_bac_1 216596022198 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 216596022199 classical (c) SDRs; Region: SDR_c; cd05233 216596022200 NAD(P) binding site [chemical binding]; other site 216596022201 active site 216596022202 Pfam match to entry PF00106.11 adh_short 216596022203 Transcriptional regulators [Transcription]; Region: FadR; COG2186 216596022204 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596022205 DNA-binding site [nucleotide binding]; DNA binding site 216596022206 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 216596022207 Pfam match to entry PF00392.9 GntR 216596022208 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 216596022209 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 216596022210 active site pocket [active] 216596022211 Pfam match to entry PF02746.4 MR_MLE_N 216596022212 Pfam match to entry PF01188.9 MR_MLE 216596022213 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 216596022214 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 216596022215 classical (c) SDRs; Region: SDR_c; cd05233 216596022216 NAD(P) binding site [chemical binding]; other site 216596022217 active site 216596022218 Pfam match to entry PF00106.11 adh_short 216596022219 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 216596022220 Cytochrome c; Region: Cytochrom_C; cl11414 216596022221 methyltransferase, pseudogene; Codons 30 to the C-terminus are similar to codons 225 to the C-terminus of Streptomyces glaucescens TcmO tetracenomycin polyketide synthesis 8-o-methyl transferase (ec 2.1.1.-). UniProt:TCMO_STRGA (EMBL:SGTCREP) (339 aa), and codons 30 to the C-terminus are similar to codons 235 to the C-terminus of Gallus gallus (Chicken) AsmT hydroxyindole O-methyltransferase (ec 2.1.1.4) (hiomt) (acetylserotonin o-methyltransferase) (asmt). UniProt:HIOM_CHICK (EMBL:GDHOMT) (346 aa); similarity:fasta; with=UniProt:TCMO_STRGA (EMBL:SGTCREP); Streptomyces glaucescens.; tcmO; Tetracenomycin polyketide synthesis 8-O-methyl transferase tcmO (EC 2.1.1.-).; length=339; id 38.983; 118 aa overlap; query 29-143; subject 224-338; similarity:fasta; with=UniProt:HIOM_CHICK (EMBL:GDHOMT); Gallus gallus (Chicken).; ASMT; Hydroxyindole O-methyltransferase (EC 2.1.1.4) (HIOMT) (Acetylserotonin O-methyltransferase) (ASMT).; length=346; id 38.938; 113 aa overlap; query 31-142; subject 236-346 216596022222 hypothetical protein; Validated; Region: PRK08245 216596022223 Pfam match to entry PF03737.4 Methyltransf_6 216596022224 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 216596022225 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 216596022226 active site pocket [active] 216596022227 Pfam match to entry PF01188.9 MR_MLE 216596022228 Pfam match to entry PF02746.4 MR_MLE_N 216596022229 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 216596022230 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 216596022231 Walker A/P-loop; other site 216596022232 ATP binding site [chemical binding]; other site 216596022233 Q-loop/lid; other site 216596022234 ABC transporter signature motif; other site 216596022235 Walker B; other site 216596022236 D-loop; other site 216596022237 H-loop/switch region; other site 216596022238 TOBE domain; Region: TOBE; pfam03459 216596022239 Pfam match to entry PF03459.4 TOBE 216596022240 Pfam match to entry PF00005.11 ABC_tran 216596022241 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216596022242 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596022243 dimer interface [polypeptide binding]; other site 216596022244 conserved gate region; other site 216596022245 putative PBP binding loops; other site 216596022246 ABC-ATPase subunit interface; other site 216596022247 Pfam match to entry PF00528.10 BPD_transp_1 216596022248 6 probable transmembrane helices predicted at aa 24-46, 93-115, 127-149, 159-181,202-224 and 262-281 216596022249 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 216596022250 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596022251 dimer interface [polypeptide binding]; other site 216596022252 conserved gate region; other site 216596022253 putative PBP binding loops; other site 216596022254 ABC-ATPase subunit interface; other site 216596022255 Pfam match to entry PF00528.10 BPD_transp_1 216596022256 6 probable transmembrane helices predicted at aa 45-67, 107-129, 136-158, 185-202,249-271 and 297-319 216596022257 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 216596022258 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 216596022259 Pfam match to entry PF01547.11 SBP_bac_1 216596022260 Transcriptional regulators [Transcription]; Region: GntR; COG1802 216596022261 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596022262 DNA-binding site [nucleotide binding]; DNA binding site 216596022263 FCD domain; Region: FCD; pfam07729 216596022264 Pfam match to entry PF00392.9 GntR 216596022265 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 216596022266 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 216596022267 active site pocket [active] 216596022268 Pfam match to entry PF02746.4 MR_MLE_N 216596022269 Pfam match to entry PF01188.9 MR_MLE 216596022270 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 216596022271 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 216596022272 active site pocket [active] 216596022273 Pfam match to entry PF02746.4 MR_MLE_N 216596022274 Pfam match to entry PF01188.9 MR_MLE 216596022275 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 216596022276 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 216596022277 active site pocket [active] 216596022278 Pfam match to entry PF02746.4 MR_MLE_N 216596022279 Pfam match to entry PF01188.9 MR_MLE 216596022280 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 216596022281 1 probable transmembrane helix predicted at aa 84-101 216596022282 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 216596022283 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 216596022284 RNA binding surface [nucleotide binding]; other site 216596022285 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 216596022286 active site 216596022287 Pfam match to entry PF01479.9 S4 216596022288 Pfam match to entry PF00849.9 PseudoU_synth_2 216596022289 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 216596022290 active site 216596022291 Pfam match to entry PF00156.11 Pribosyltran 216596022292 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 216596022293 transmembrane helices; other site 216596022294 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 216596022295 TrkA-C domain; Region: TrkA_C; pfam02080 216596022296 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 216596022297 12 probable transmembrane helices predicted at aa 7-21, 26-43, 48-70, 100-122,135-157, 172-194, 388-407, 412-429, 436-455, 465-487,520-537 and 557-579 216596022298 Pfam match to entry PF02080.7 TrkA_C 216596022299 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 216596022300 ATP binding site [chemical binding]; other site 216596022301 active site 216596022302 substrate binding site [chemical binding]; other site 216596022303 Pfam match to entry PF01259.8 SAICAR_synt 216596022304 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216596022305 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216596022306 Pfam match to entry PF00440.8 TetR_N 216596022307 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 216596022308 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 216596022309 HlyD family secretion protein; Region: HlyD_3; pfam13437 216596022310 Pfam match to entry PF00529.8 HlyD 216596022311 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 216596022312 Protein export membrane protein; Region: SecD_SecF; cl14618 216596022313 Pfam match to entry PF00873.7 ACR_tran 216596022314 12 probable transmembrane helices predicted at aa 13-35, 339-358, 365-387, 391-413,437-459, 474-496, 533-552, 867-886, 891-913, 923-942,963-985 and 1000-1022 216596022315 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 216596022316 Pfam match to entry PF02321.6 OEP 216596022317 Pfam match to entry PF02321.6 OEP 216596022318 Transcriptional regulators [Transcription]; Region: PurR; COG1609 216596022319 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216596022320 DNA binding site [nucleotide binding] 216596022321 domain linker motif; other site 216596022322 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 216596022323 dimerization interface [polypeptide binding]; other site 216596022324 ligand binding site [chemical binding]; other site 216596022325 Pfam match to entry PF00532.8 Peripla_BP_1 216596022326 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 216596022327 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 216596022328 Pfam match to entry PF01547.11 SBP_bac_1 216596022329 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 216596022330 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596022331 dimer interface [polypeptide binding]; other site 216596022332 conserved gate region; other site 216596022333 putative PBP binding loops; other site 216596022334 ABC-ATPase subunit interface; other site 216596022335 6 probable transmembrane helices predicted at aa 9-31, 67-89, 96-118, 145-167,201-223 and 243-265 216596022336 Pfam match to entry PF00528.10 BPD_transp_1 216596022337 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 216596022338 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596022339 dimer interface [polypeptide binding]; other site 216596022340 conserved gate region; other site 216596022341 putative PBP binding loops; other site 216596022342 ABC-ATPase subunit interface; other site 216596022343 6 probable transmembrane helices predicted at aa 5-27, 65-87, 100-122, 126-148,185-207 and 227-249 216596022344 Pfam match to entry PF00528.10 BPD_transp_1 216596022345 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 216596022346 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216596022347 Walker A/P-loop; other site 216596022348 ATP binding site [chemical binding]; other site 216596022349 Q-loop/lid; other site 216596022350 ABC transporter signature motif; other site 216596022351 Walker B; other site 216596022352 D-loop; other site 216596022353 H-loop/switch region; other site 216596022354 Pfam match to entry PF00005.11 ABC_tran 216596022355 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 216596022356 active site 216596022357 Pfam match to entry PF01156.8 IU_nuc_hydro 216596022358 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 216596022359 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 216596022360 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 216596022361 active site 216596022362 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 216596022363 Pfam match to entry PF01979.7 Amidohydro_1 216596022364 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 216596022365 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 216596022366 metal binding site [ion binding]; metal-binding site 216596022367 1 probable transmembrane helix predicted at aa 7-29 216596022368 Pfam match to entry PF01297.7 SBP_bac_9 216596022369 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 216596022370 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 216596022371 Pfam match to entry PF00005.11 ABC_tran 216596022372 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 216596022373 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 216596022374 ABC-ATPase subunit interface; other site 216596022375 dimer interface [polypeptide binding]; other site 216596022376 putative PBP binding regions; other site 216596022377 Pfam match to entry PF00950.7 ABC-3 216596022378 8 probable transmembrane helices predicted at aa 13-35, 50-72, 93-112, 127-149,169-191, 195-214, 221-243 and 248-267 216596022379 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 216596022380 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 216596022381 ABC-ATPase subunit interface; other site 216596022382 dimer interface [polypeptide binding]; other site 216596022383 putative PBP binding regions; other site 216596022384 Pfam match to entry PF00950.7 ABC-3 216596022385 8 probable transmembrane helices predicted at aa 20-42, 52-74, 95-117, 137-159,171-193, 197-216, 223-245 and 249-266 216596022386 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 216596022387 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 216596022388 metal binding site [ion binding]; metal-binding site 216596022389 putative dimer interface [polypeptide binding]; other site 216596022390 Pfam match to entry PF01546.12 Peptidase_M20 216596022391 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 216596022392 12 probable transmembrane helices predicted at aa 21-52, 62-84, 111-133, 138-160,167-189, 204-226, 260-282, 321-343, 355-377, 387-409,411-428 and 465-487 216596022393 Pfam match to entry PF01970.6 DUF112 216596022394 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 216596022395 Pfam match to entry PF07331.1 DUF1468 216596022396 4 probable transmembrane helices predicted at aa 39-61, 74-96, 111-133 and 153-175 216596022397 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 216596022398 Pfam match to entry PF03401.3 Bug 216596022399 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 216596022400 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596022401 active site 216596022402 phosphorylation site [posttranslational modification] 216596022403 intermolecular recognition site; other site 216596022404 dimerization interface [polypeptide binding]; other site 216596022405 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216596022406 Walker A motif; other site 216596022407 ATP binding site [chemical binding]; other site 216596022408 Walker B motif; other site 216596022409 arginine finger; other site 216596022410 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 216596022411 Pfam match to entry PF02954.7 HTH_8 216596022412 Pfam match to entry PF00158.12 Sigma54_activat 216596022413 Pfam match to entry PF00072.9 Response_reg 216596022414 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 216596022415 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216596022416 dimer interface [polypeptide binding]; other site 216596022417 phosphorylation site [posttranslational modification] 216596022418 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596022419 ATP binding site [chemical binding]; other site 216596022420 Mg2+ binding site [ion binding]; other site 216596022421 G-X-G motif; other site 216596022422 Pfam match to entry PF02518.9 HATPase_c 216596022423 Pfam match to entry PF00512.10 HisKA 216596022424 1 probable transmembrane helix predicted at aa 283-305 216596022425 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 216596022426 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 216596022427 Moco binding site; other site 216596022428 metal coordination site [ion binding]; other site 216596022429 Pfam match to entry PF00174.8 Oxidored_molyb 216596022430 2 probable transmembrane helices predicted at aa 7-29 and 176-198 216596022431 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 216596022432 6 probable transmembrane helices predicted at aa 5-27, 65-87, 100-117, 132-154,167-189 and 204-226 216596022433 Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723 216596022434 1 probable transmembrane helix predicted at aa 91-110 216596022435 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 216596022436 catalytic core [active] 216596022437 Pfam match to entry PF00300.9 PGAM 216596022438 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216596022439 metal binding site [ion binding]; metal-binding site 216596022440 active site 216596022441 I-site; other site 216596022442 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216596022443 2 probable transmembrane helices predicted at aa 4-26 and 38-60 216596022444 Pfam match to entry PF00990.8 GGDEF 216596022445 Pfam match to entry PF00563.9 EAL 216596022446 propionate/acetate kinase; Provisional; Region: PRK12379 216596022447 acetate kinase; Provisional; Region: PRK07058 216596022448 Pfam match to entry PF00871.7 Acetate_kinase 216596022449 putative phosphoketolase; Provisional; Region: PRK05261 216596022450 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 216596022451 TPP-binding site; other site 216596022452 XFP C-terminal domain; Region: XFP_C; pfam09363 216596022453 Pfam match to entry PF03894.3 XFP 216596022454 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 216596022455 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 216596022456 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cl00327 216596022457 putative translocon binding site; other site 216596022458 protein-rRNA interface [nucleotide binding]; other site 216596022459 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216596022460 Pfam match to entry PF00165.8 HTH_AraC 216596022461 Pfam match to entry PF00165.8 HTH_AraC 216596022462 Pfam match to entry PF02311.7 AraC_binding 216596022463 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 216596022464 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 216596022465 Pfam match to entry PF01494.7 FAD_binding_3 216596022466 Pfam match to entry PF01360.9 Monooxygenase 216596022467 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 216596022468 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 216596022469 Pfam match to entry PF01094.13 ANF_receptor 216596022470 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 216596022471 TM-ABC transporter signature motif; other site 216596022472 8 probable transmembrane helices predicted at aa 15-37, 50-69, 73-95, 112-134,154-176, 206-228, 243-265 and 278-300 216596022473 Pfam match to entry PF02653.5 BPD_transp_2 216596022474 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 216596022475 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 216596022476 TM-ABC transporter signature motif; other site 216596022477 9 probable transmembrane helices predicted at aa 23-40, 45-67, 72-94, 98-120,125-142, 173-195, 222-244, 264-286 and 293-315 216596022478 Pfam match to entry PF02653.5 BPD_transp_2 216596022479 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 216596022480 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 216596022481 Walker A/P-loop; other site 216596022482 ATP binding site [chemical binding]; other site 216596022483 Q-loop/lid; other site 216596022484 ABC transporter signature motif; other site 216596022485 Walker B; other site 216596022486 D-loop; other site 216596022487 H-loop/switch region; other site 216596022488 Pfam match to entry PF00005.11 ABC_tran 216596022489 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 216596022490 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 216596022491 Walker A/P-loop; other site 216596022492 ATP binding site [chemical binding]; other site 216596022493 Q-loop/lid; other site 216596022494 ABC transporter signature motif; other site 216596022495 Walker B; other site 216596022496 D-loop; other site 216596022497 H-loop/switch region; other site 216596022498 Pfam match to entry PF00005.11 ABC_tran 216596022499 similarity:fasta; with=UniProt:Q9F7Z2_RHILT (EMBL:AF265223); Rhizobium leguminosarum (biovar trifolii).; rapB; Rhizobium-adhering protein RapB. Rhizobium-adhering protein RapB.; length=279; id 97.133; 279 aa overlap; query 1-279; subject 1-279 216596022500 DNA-sulfur modification-associated; Region: DndB; cl17621 216596022501 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 216596022502 Pfam match to entry PF01402.8 HTH_4 216596022503 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 216596022504 8 probable transmembrane helices predicted at aa 5-27, 42-64, 73-95, 110-131,152-174, 244-266, 314-336 and 364-386 216596022505 Pfam match to entry PF03062.7 MBOAT 216596022506 1 probable transmembrane helix predicted at aa 74-96 216596022507 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 216596022508 catalytic residues [active] 216596022509 Pfam match to entry PF00959.8 Phage_lysozyme 216596022510 2 probable transmembrane helices predicted at aa 13-35 and 45-67 216596022511 1 probable transmembrane helix predicted at aa 7-29 216596022512 2 probable transmembrane helices predicted at aa 20-37 and 44-63 216596022513 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 216596022514 N-acetyl-D-glucosamine binding site [chemical binding]; other site 216596022515 catalytic residue [active] 216596022516 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 216596022517 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 216596022518 Pfam match to entry PF00583.9 Acetyltransf_1 216596022519 large terminase protein; Provisional; Region: 17; PHA02533 216596022520 2 probable transmembrane helices predicted at aa 26-48 and 68-90 216596022521 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 216596022522 active site 216596022523 metal binding site [ion binding]; metal-binding site 216596022524 interdomain interaction site; other site 216596022525 Replicative DNA helicase [DNA replication, recombination, and repair]; Region: DnaB; COG0305 216596022526 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 216596022527 Walker A motif; other site 216596022528 ATP binding site [chemical binding]; other site 216596022529 Walker B motif; other site 216596022530 Protein of unknown function (DUF1376); Region: DUF1376; cl01531 216596022531 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 216596022532 non-specific DNA binding site [nucleotide binding]; other site 216596022533 salt bridge; other site 216596022534 sequence-specific DNA binding site [nucleotide binding]; other site 216596022535 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 216596022536 Arc-like DNA binding domain; Region: Arc; pfam03869 216596022537 Pfam match to entry PF03869.3 Arc 216596022538 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 216596022539 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 216596022540 catalytic residues [active] 216596022541 catalytic nucleophile [active] 216596022542 Recombinase; Region: Recombinase; pfam07508 216596022543 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 216596022544 Pfam match to entry PF00239.10 Resolvase 216596022545 Pfam match to entry PF07508.1 Recombinase 216596022546 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 216596022547 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 216596022548 Ligand Binding Site [chemical binding]; other site 216596022549 Pfam match to entry PF03054.5 tRNA_Me_trans 216596022550 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216596022551 PAS domain; Region: PAS_9; pfam13426 216596022552 putative active site [active] 216596022553 heme pocket [chemical binding]; other site 216596022554 PAS fold; Region: PAS_4; pfam08448 216596022555 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216596022556 putative active site [active] 216596022557 heme pocket [chemical binding]; other site 216596022558 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 216596022559 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216596022560 metal binding site [ion binding]; metal-binding site 216596022561 active site 216596022562 I-site; other site 216596022563 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216596022564 Pfam match to entry PF00563.9 EAL 216596022565 Pfam match to entry PF00990.8 GGDEF 216596022566 Pfam match to entry PF00989.11 PAS 216596022567 Pfam match to entry PF00989.11 PAS 216596022568 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 216596022569 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 216596022570 ligand binding site [chemical binding]; other site 216596022571 NAD binding site [chemical binding]; other site 216596022572 dimerization interface [polypeptide binding]; other site 216596022573 catalytic site [active] 216596022574 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 216596022575 putative L-serine binding site [chemical binding]; other site 216596022576 Pfam match to entry PF01842.8 ACT 216596022577 Pfam match to entry PF02826.5 2-Hacid_dh_C 216596022578 Pfam match to entry PF00389.14 2-Hacid_dh 216596022579 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 216596022580 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216596022581 catalytic residue [active] 216596022582 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 216596022583 1 probable transmembrane helix predicted at aa 27-49 216596022584 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 216596022585 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 216596022586 active site 216596022587 substrate binding site [chemical binding]; other site 216596022588 metal binding site [ion binding]; metal-binding site 216596022589 Pfam match to entry PF00408.9 PGM_PMM_IV 216596022590 Pfam match to entry PF02880.5 PGM_PMM_III 216596022591 Pfam match to entry PF02879.5 PGM_PMM_II 216596022592 Pfam match to entry PF02878.5 PGM_PMM_I 216596022593 FtsH Extracellular; Region: FtsH_ext; pfam06480 216596022594 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 216596022595 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216596022596 Walker A motif; other site 216596022597 ATP binding site [chemical binding]; other site 216596022598 Walker B motif; other site 216596022599 arginine finger; other site 216596022600 Peptidase family M41; Region: Peptidase_M41; pfam01434 216596022601 Pfam match to entry PF01434.6 Peptidase_M41 216596022602 Pfam match to entry PF00004.12 AAA 216596022603 Pfam match to entry PF06480.2 FtsH_ext 216596022604 2 probable transmembrane helices predicted at aa 7-29 and 105-127 216596022605 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 216596022606 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 216596022607 Pfam match to entry PF01171.9 ATP_bind_3 216596022608 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 216596022609 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216596022610 TPR motif; other site 216596022611 binding surface 216596022612 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 216596022613 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 216596022614 ligand binding site [chemical binding]; other site 216596022615 Pfam match to entry PF00691.7 OmpA 216596022616 translocation protein TolB; Provisional; Region: tolB; PRK05137 216596022617 TolB amino-terminal domain; Region: TolB_N; pfam04052 216596022618 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 216596022619 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 216596022620 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 216596022621 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 216596022622 Pfam match to entry PF04052.3 TolB_N 216596022623 1 probable transmembrane helix predicted at aa 7-29 216596022624 TolA outer membrane protein,pseudogene; Codons 30 to the C-terminus are similar to codons 280 to the C-terminus of Agrobacterium tumefaciens (strain C58/ATCC 33970) hypothetical protein TolA (agr_l_2241p). UniProt:Q8U9L3_AGRT5 (EMBL:AE008311) (384 aa); similarity:fasta; with=UniProt:Q8U9L3_AGRT5 (EMBL:AE008311); Agrobacterium tumefaciens (strain C58/ATCC 33970).; tolA; Hypothetical protein tolA (AGR_L_2241p).; length=384; id 41.121; 107 aa overlap; query 31-136; subject 278-381 216596022625 Signal peptide predicted for RL3970 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.975 between residues 30 and 31 216596022626 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 216596022627 TolR protein; Region: tolR; TIGR02801 216596022628 Pfam match to entry PF02472.5 ExbD 216596022629 1 probable transmembrane helix predicted at aa 25-47 216596022630 TolQ protein; Region: tolQ; TIGR02796 216596022631 Pfam match to entry PF01618.6 MotA_ExbB 216596022632 3 probable transmembrane helices predicted at aa 23-45, 134-156 and 171-193 216596022633 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 216596022634 active site 216596022635 Pfam match to entry PF03061.8 4HBT 216596022636 UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255 216596022637 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 216596022638 NAD binding site [chemical binding]; other site 216596022639 substrate binding site [chemical binding]; other site 216596022640 active site 216596022641 Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen; Region: GT8_Glycogenin; cd02537 216596022642 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 216596022643 substrate binding site; other site 216596022644 Manganese binding site; other site 216596022645 dimer interface; other site 216596022646 Pfam match to entry PF01501.8 Glyco_transf_8 216596022647 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 216596022648 extended (e) SDRs; Region: SDR_e; cd08946 216596022649 NAD(P) binding site [chemical binding]; other site 216596022650 active site 216596022651 substrate binding site [chemical binding]; other site 216596022652 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 216596022653 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 216596022654 Pfam match to entry PF01812.9 5-FTHF_cyc-lig 216596022655 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 216596022656 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 216596022657 putative active site [active] 216596022658 metal binding site [ion binding]; metal-binding site 216596022659 homodimer binding site [polypeptide binding]; other site 216596022660 Pfam match to entry PF00149.12 Metallophos 216596022661 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 216596022662 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 216596022663 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 216596022664 hypothetical protein; Validated; Region: PRK00110 216596022665 Pfam match to entry PF01709.8 DUF28 216596022666 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 216596022667 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 216596022668 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 216596022669 Pfam match to entry PF00296.10 Bac_luciferase 216596022670 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 216596022671 dimerization interface [polypeptide binding]; other site 216596022672 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 216596022673 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 216596022674 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 216596022675 dimer interface [polypeptide binding]; other site 216596022676 putative CheW interface [polypeptide binding]; other site 216596022677 Pfam match to entry PF00015.9 MCPsignal 216596022678 Pfam match to entry PF00672.10 HAMP 216596022679 2 probable transmembrane helices predicted at aa 82-104 and 417-439 216596022680 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 216596022681 active site 216596022682 putative DNA-binding cleft [nucleotide binding]; other site 216596022683 dimer interface [polypeptide binding]; other site 216596022684 Pfam match to entry PF02075.5 RuvC 216596022685 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 216596022686 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 216596022687 Pfam match to entry PF04014.4 SpoVT_AbrB 216596022688 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875 216596022689 putative active site [active] 216596022690 Pfam match to entry PF01850.8 PIN 216596022691 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 216596022692 RuvA N terminal domain; Region: RuvA_N; pfam01330 216596022693 Pfam match to entry PF01330.10 RuvA_N 216596022694 Pfam match to entry PF07499.1 RuvA_C 216596022695 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 216596022696 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216596022697 Walker A motif; other site 216596022698 ATP binding site [chemical binding]; other site 216596022699 Walker B motif; other site 216596022700 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 216596022701 Pfam match to entry PF05496.1 RuvB_N 216596022702 Pfam match to entry PF00004.12 AAA 216596022703 Pfam match to entry PF05491.2 RuvB_C 216596022704 phosphodiesterase YaeI; Provisional; Region: PRK11340 216596022705 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 216596022706 putative active site [active] 216596022707 putative metal binding site [ion binding]; other site 216596022708 1 probable transmembrane helix predicted at aa 7-29 216596022709 Pfam match to entry PF00149.12 Metallophos 216596022710 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 216596022711 nudix motif; other site 216596022712 Pfam match to entry PF00293.12 NUDIX 216596022713 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 216596022714 DinB superfamily; Region: DinB_2; pfam12867 216596022715 Pfam match to entry PF05163.2 DinB 216596022716 Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946 216596022717 Bacterial virulence protein (VirJ); Region: VirJ; pfam06057 216596022718 Pfam match to entry PF06057.1 VirJ 216596022719 Predicted integral membrane protein [Function unknown]; Region: COG0392 216596022720 Uncharacterized conserved protein [Function unknown]; Region: COG2898 216596022721 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 216596022722 Pfam match to entry PF04331.2 DUF472 216596022723 Pfam match to entry PF04330.2 DUF471 216596022724 Pfam match to entry PF04329.2 DUF470 216596022725 13 probable transmembrane helices predicted at aa 29-48, 68-90, 103-125, 145-167,180-202, 222-244, 251-273, 298-320, 341-363, 378-400,412-443, 463-485 and 506-528 216596022726 Pfam match to entry PF04173.2 DoxD 216596022727 3 probable transmembrane helices predicted at aa 9-31, 51-73 and 94-116 216596022728 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 216596022729 Mechanosensitive ion channel; Region: MS_channel; pfam00924 216596022730 Pfam match to entry PF00924.8 MS_channel 216596022731 12 probable transmembrane helices predicted at aa 55-77, 169-191, 212-234, 249-271,292-311, 326-345, 358-377, 382-404, 425-444, 459-480,512-534 and 539-561 216596022732 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 216596022733 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 216596022734 Pfam match to entry PF00393.7 6PGD 216596022735 Pfam match to entry PF03446.3 NAD_binding_2 216596022736 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 216596022737 hydrophobic ligand binding site; other site 216596022738 Pfam match to entry PF05146.3 DUF704 216596022739 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216596022740 dimerization interface [polypeptide binding]; other site 216596022741 putative DNA binding site [nucleotide binding]; other site 216596022742 putative Zn2+ binding site [ion binding]; other site 216596022743 Pfam match to entry PF01022.8 HTH_5 216596022744 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216596022745 non-specific DNA binding site [nucleotide binding]; other site 216596022746 salt bridge; other site 216596022747 sequence-specific DNA binding site [nucleotide binding]; other site 216596022748 Pfam match to entry PF01381.9 HTH_3 216596022749 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216596022750 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 216596022751 NAD(P) binding site [chemical binding]; other site 216596022752 active site 216596022753 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 216596022754 1 probable transmembrane helix predicted at aa 7-29 216596022755 Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division, chromosome partitioning]; Region: zapA; COG3027 216596022756 Pfam match to entry PF05164.2 DUF710 216596022757 Domain of unknown function (DUF4164); Region: DUF4164; pfam13747 216596022758 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 216596022759 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 216596022760 TPP-binding site [chemical binding]; other site 216596022761 dimer interface [polypeptide binding]; other site 216596022762 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 216596022763 PYR/PP interface [polypeptide binding]; other site 216596022764 dimer interface [polypeptide binding]; other site 216596022765 TPP binding site [chemical binding]; other site 216596022766 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 216596022767 Pfam match to entry PF00456.9 Transketolase_N 216596022768 Pfam match to entry PF02779.8 Transket_pyr 216596022769 Pfam match to entry PF02780.6 Transketolase_C 216596022770 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 216596022771 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 216596022772 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 216596022773 Pfam match to entry PF00044.9 Gp_dh_N 216596022774 Pfam match to entry PF02800.5 Gp_dh_C 216596022775 1 probable transmembrane helix predicted at aa 36-58 216596022776 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 216596022777 Transporter associated domain; Region: CorC_HlyC; cl08393 216596022778 12 probable transmembrane helices predicted at aa 5-27, 34-52, 57-79, 91-113,123-145, 165-184, 194-216, 228-261, 276-293, 300-322,337-359 and 366-385 216596022779 Pfam match to entry PF00999.9 Na_H_Exchanger 216596022780 Pfam match to entry PF03471.5 CorC_HlyC 216596022781 Phosphoglycerate kinase; Region: PGK; pfam00162 216596022782 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 216596022783 substrate binding site [chemical binding]; other site 216596022784 hinge regions; other site 216596022785 ADP binding site [chemical binding]; other site 216596022786 catalytic site [active] 216596022787 Pfam match to entry PF00162.7 PGK 216596022788 Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948 216596022789 active site 216596022790 intersubunit interface [polypeptide binding]; other site 216596022791 catalytic residue [active] 216596022792 Pfam match to entry PF00274.8 Glycolytic 216596022793 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 216596022794 Pfam match to entry PF02567.5 PhzC-PhzF 216596022795 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596022796 putative MFS family transporter protein; Provisional; Region: PRK03633 216596022797 putative substrate translocation pore; other site 216596022798 12 probable transmembrane helices predicted at aa 16-38, 48-70, 83-102, 107-129,141-160, 170-192, 213-235, 245-267, 274-296, 300-322,335-357 and 361-383 216596022799 Protein of unknown function (DUF1192); Region: DUF1192; pfam06698 216596022800 Pfam match to entry PF06698.1 DUF1192 216596022801 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5317 216596022802 Pfam match to entry PF07323.1 DUF1465 216596022803 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 216596022804 Pfam match to entry PF01197.7 Ribosomal_L31 216596022805 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 216596022806 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 216596022807 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 216596022808 Walker A/P-loop; other site 216596022809 ATP binding site [chemical binding]; other site 216596022810 Q-loop/lid; other site 216596022811 ABC transporter signature motif; other site 216596022812 Walker B; other site 216596022813 D-loop; other site 216596022814 H-loop/switch region; other site 216596022815 5 probable transmembrane helices predicted at aa 30-52, 72-94, 150-167, 172-194 and 254-276 216596022816 Pfam match to entry PF00664.9 ABC_membrane 216596022817 Pfam match to entry PF00005.11 ABC_tran 216596022818 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 216596022819 1 probable transmembrane helix predicted at aa 12-31 216596022820 Pfam match to entry PF03401.3 Bug 216596022821 Uncharacterized conserved protein [Function unknown]; Region: COG3422 216596022822 Pfam match to entry PF07411.1 DUF1508 216596022823 YCII-related domain; Region: YCII; cl00999 216596022824 Pfam match to entry PF04946.2 DGPF 216596022825 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 216596022826 Pfam match to entry PF04542.2 Sigma70_r2 216596022827 hypothetical protein; Validated; Region: PRK09039 216596022828 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 216596022829 ligand binding site [chemical binding]; other site 216596022830 Pfam match to entry PF00691.7 OmpA 216596022831 1 probable transmembrane helix predicted at aa 20-42 216596022832 4 probable transmembrane helices predicted at aa 29-51, 61-83, 150-172 and 204-226 216596022833 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 216596022834 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 216596022835 active site 216596022836 dimerization interface [polypeptide binding]; other site 216596022837 Pfam match to entry PF00459.10 Inositol_P 216596022838 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216596022839 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216596022840 Pfam match to entry PF00440.8 TetR_N 216596022841 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 216596022842 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216596022843 NAD(P) binding site [chemical binding]; other site 216596022844 active site 216596022845 Pfam match to entry PF00106.11 adh_short 216596022846 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 216596022847 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596022848 active site 216596022849 phosphorylation site [posttranslational modification] 216596022850 intermolecular recognition site; other site 216596022851 CheB methylesterase; Region: CheB_methylest; pfam01339 216596022852 Pfam match to entry PF01339.7 CheB_methylest 216596022853 Pfam match to entry PF00072.9 Response_reg 216596022854 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 216596022855 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 216596022856 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 216596022857 Pfam match to entry PF01739.8 CheR 216596022858 Pfam match to entry PF03705.5 CheR_N 216596022859 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 216596022860 Pfam match to entry PF01584.7 CheW 216596022861 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 216596022862 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 216596022863 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 216596022864 dimerization interface [polypeptide binding]; other site 216596022865 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 216596022866 dimer interface [polypeptide binding]; other site 216596022867 putative CheW interface [polypeptide binding]; other site 216596022868 Pfam match to entry PF00015.9 MCPsignal 216596022869 Pfam match to entry PF00672.10 HAMP 216596022870 2 probable transmembrane helices predicted at aa 13-35 and 191-213 216596022871 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 216596022872 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 216596022873 dimerization interface [polypeptide binding]; other site 216596022874 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 216596022875 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 216596022876 dimer interface [polypeptide binding]; other site 216596022877 putative CheW interface [polypeptide binding]; other site 216596022878 Pfam match to entry PF00015.9 MCPsignal 216596022879 Pfam match to entry PF00672.10 HAMP 216596022880 2 probable transmembrane helices predicted at aa 57-79 and 234-256 216596022881 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 216596022882 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 216596022883 dimerization interface [polypeptide binding]; other site 216596022884 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 216596022885 dimer interface [polypeptide binding]; other site 216596022886 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 216596022887 putative CheW interface [polypeptide binding]; other site 216596022888 Pfam match to entry PF00015.9 MCPsignal 216596022889 Pfam match to entry PF00672.10 HAMP 216596022890 2 probable transmembrane helices predicted at aa 4-26 and 180-202 216596022891 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 216596022892 Pfam match to entry PF01584.7 CheW 216596022893 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 216596022894 putative binding surface; other site 216596022895 active site 216596022896 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 216596022897 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 216596022898 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596022899 ATP binding site [chemical binding]; other site 216596022900 Mg2+ binding site [ion binding]; other site 216596022901 G-X-G motif; other site 216596022902 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 216596022903 Pfam match to entry PF01584.7 CheW 216596022904 Pfam match to entry PF02518.9 HATPase_c 216596022905 Pfam match to entry PF02895.4 H-kinase_dim 216596022906 Pfam match to entry PF01627.9 Hpt 216596022907 Response regulator receiver domain; Region: Response_reg; pfam00072 216596022908 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596022909 active site 216596022910 phosphorylation site [posttranslational modification] 216596022911 intermolecular recognition site; other site 216596022912 dimerization interface [polypeptide binding]; other site 216596022913 Pfam match to entry PF00072.9 Response_reg 216596022914 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 216596022915 methyl-accepting protein IV; Provisional; Region: PRK09793 216596022916 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 216596022917 Sel1-like repeats; Region: SEL1; smart00671 216596022918 Sel1-like repeats; Region: SEL1; smart00671 216596022919 Sel1-like repeats; Region: SEL1; smart00671 216596022920 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 216596022921 thiamine phosphate binding site [chemical binding]; other site 216596022922 active site 216596022923 pyrophosphate binding site [ion binding]; other site 216596022924 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 216596022925 7 probable transmembrane helices predicted at aa 7-29, 34-56, 76-95, 99-118,139-161, 202-224 and 231-253 216596022926 Pfam match to entry PF01925.8 DUF81 216596022927 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216596022928 dimerization interface [polypeptide binding]; other site 216596022929 putative DNA binding site [nucleotide binding]; other site 216596022930 putative Zn2+ binding site [ion binding]; other site 216596022931 Pfam match to entry PF01022.8 HTH_5 216596022932 Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481 216596022933 Pfam match to entry PF04325.2 DUF465 216596022934 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 216596022935 Pfam match to entry PF00731.9 AIRC 216596022936 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 216596022937 ATP-grasp domain; Region: ATP-grasp; pfam02222 216596022938 Pfam match to entry PF02222.7 ATP-grasp 216596022939 TPR repeat; Region: TPR_11; pfam13414 216596022940 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216596022941 TPR motif; other site 216596022942 binding surface 216596022943 1 probable transmembrane helix predicted at aa 21-43 216596022944 Pfam match to entry PF00515.11 TPR 216596022945 Pfam match to entry PF00515.11 TPR 216596022946 Pfam match to entry PF00515.11 TPR 216596022947 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 216596022948 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 216596022949 catalytic site [active] 216596022950 Pfam match to entry PF00561.8 Abhydrolase_1 216596022951 short chain dehydrogenase; Provisional; Region: PRK07041 216596022952 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216596022953 NAD(P) binding site [chemical binding]; other site 216596022954 active site 216596022955 Pfam match to entry PF00106.11 adh_short 216596022956 Helix-turn-helix domain; Region: HTH_31; pfam13560 216596022957 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 216596022958 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 216596022959 Pfam match to entry PF01019.9 G_glu_transpept 216596022960 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 216596022961 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 216596022962 tetramer interface [polypeptide binding]; other site 216596022963 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596022964 catalytic residue [active] 216596022965 Pfam match to entry PF00291.10 PALP 216596022966 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 216596022967 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216596022968 NAD(P) binding site [chemical binding]; other site 216596022969 active site 216596022970 Pfam match to entry PF00106.11 adh_short 216596022971 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 216596022972 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 216596022973 conserved cys residue [active] 216596022974 Pfam match to entry PF01965.9 DJ-1_PfpI 216596022975 Pfam match to entry PF00165.8 HTH_AraC 216596022976 Pfam match to entry PF00165.8 HTH_AraC 216596022977 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 216596022978 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 216596022979 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596022980 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216596022981 dimerization interface [polypeptide binding]; other site 216596022982 Pfam match to entry PF03466.5 LysR_substrate 216596022983 Pfam match to entry PF00126.10 HTH_1 216596022984 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 216596022985 Pfam match to entry PF01361.9 Tautomerase 216596022986 Pfam match to entry PF01361.9 Tautomerase 216596022987 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 216596022988 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 216596022989 Pfam match to entry PF01810.7 LysE 216596022990 5 probable transmembrane helices predicted at aa 4-26, 39-61, 71-93, 153-172 and 187-206 216596022991 pyruvate kinase; Provisional; Region: PRK06247 216596022992 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 216596022993 domain interfaces; other site 216596022994 active site 216596022995 Pfam match to entry PF02887.4 PK_C 216596022996 Pfam match to entry PF00224.9 PK 216596022997 Predicted integral membrane protein [Function unknown]; Region: COG5480 216596022998 Pfam match to entry PF06282.1 DUF1036 216596022999 Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931 216596023000 Pfam match to entry PF05013.2 FGase 216596023001 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492 216596023002 Pfam match to entry PF06844.1 DUF1244 216596023003 hypothetical protein; Provisional; Region: PRK13694 216596023004 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 216596023005 Bacterial protein of unknown function (DUF882); Region: Peptidase_M15_2; pfam05951 216596023006 Pfam match to entry PF05951.1 DUF882 216596023007 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596023008 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 216596023009 active site 216596023010 phosphorylation site [posttranslational modification] 216596023011 intermolecular recognition site; other site 216596023012 dimerization interface [polypeptide binding]; other site 216596023013 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216596023014 Walker A motif; other site 216596023015 ATP binding site [chemical binding]; other site 216596023016 Walker B motif; other site 216596023017 arginine finger; other site 216596023018 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 216596023019 Pfam match to entry PF02954.7 HTH_8 216596023020 Pfam match to entry PF00158.12 Sigma54_activat 216596023021 Pfam match to entry PF00072.9 Response_reg 216596023022 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 216596023023 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 216596023024 active site 216596023025 Zn binding site [ion binding]; other site 216596023026 Pfam match to entry PF01432.8 Peptidase_M3 216596023027 aminodeoxychorismate synthase; Provisional; Region: PRK07508 216596023028 chorismate binding enzyme; Region: Chorismate_bind; cl10555 216596023029 Pfam match to entry PF00425.7 Chorismate_bind 216596023030 Similar to the C-terminus from codon 405 of Ralstonia solanacearum (Pseudomonas solanacearum) pabB. UniProt:Q68AP0_RALSO (EMBL:AB164392) (626 aa), and similar to entire protein of Rhizobium meliloti (Sinorhizobium meliloti) hypothetical protein smc04014. UniProt:Q92M55_RHIME (EMBL:SME591791) (208 aa); similarity:fasta; with=UniProt:Q68AP0_RALSO (EMBL:AB164392); Ralstonia solanacearum (Pseudomonas solanacearum).; PabB.; length=626; id 34.247; 219 aa overlap; query 3-206; subject 407-621; similarity:fasta; with=UniProt:Q92M55_RHIME (EMBL:SME591791); Rhizobium meliloti (Sinorhizobium meliloti).; Hypothetical protein SMc04014.; length=208; id 69.417; 206 aa overlap; query 1-206; subject 1-206 216596023031 YCII-related domain; Region: YCII; cl00999 216596023032 Pfam match to entry PF03795.3 YCII 216596023033 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 216596023034 Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310 216596023035 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 216596023036 1 probable transmembrane helix predicted at aa 7-29 216596023037 Pfam match to entry PF06408.1 Homo_sperm_syn 216596023038 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 216596023039 CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409 216596023040 active site 216596023041 metal binding site [ion binding]; metal-binding site 216596023042 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 216596023043 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 216596023044 Pfam match to entry PF00149.12 Metallophos 216596023045 Pfam match to entry PF02872.7 5_nucleotid_C 216596023046 Pfam match to entry PF01476.8 LysM 216596023047 ferrochelatase; Reviewed; Region: hemH; PRK00035 216596023048 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 216596023049 C-terminal domain interface [polypeptide binding]; other site 216596023050 active site 216596023051 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 216596023052 active site 216596023053 N-terminal domain interface [polypeptide binding]; other site 216596023054 Pfam match to entry PF00762.8 Ferrochelatase 216596023055 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 216596023056 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 216596023057 1 probable transmembrane helix predicted at aa 2-24 216596023058 Pfam match to entry PF01145.11 Band_7 216596023059 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 216596023060 3 probable transmembrane helices predicted at aa 5-24, 31-50 and 54-76 216596023061 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 216596023062 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 216596023063 putative active site [active] 216596023064 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 216596023065 Pfam match to entry PF00571.13 CBS 216596023066 Pfam match to entry PF00571.13 CBS 216596023067 Pfam match to entry PF01380.9 SIS 216596023068 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 216596023069 1 probable transmembrane helix predicted at aa 20-37 216596023070 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 216596023071 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 216596023072 active site 216596023073 tetramer interface; other site 216596023074 Pfam match to entry PF00483.9 NTP_transferase 216596023075 Transglycosylase SLT domain; Region: SLT_2; pfam13406 216596023076 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 216596023077 N-acetyl-D-glucosamine binding site [chemical binding]; other site 216596023078 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 216596023079 Pfam match to entry PF01471.6 PG_binding_1 216596023080 SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829 216596023081 active site 216596023082 catalytic triad [active] 216596023083 oxyanion hole [active] 216596023084 1 probable transmembrane helix predicted at aa 12-34 216596023085 Pfam match to entry PF04311.2 DUF459 216596023086 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 216596023087 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 216596023088 Pfam match to entry PF00070.12 Pyr_redox 216596023089 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 216596023090 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 216596023091 active site 216596023092 dimer interface [polypeptide binding]; other site 216596023093 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 216596023094 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 216596023095 active site 216596023096 FMN binding site [chemical binding]; other site 216596023097 substrate binding site [chemical binding]; other site 216596023098 3Fe-4S cluster binding site [ion binding]; other site 216596023099 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 216596023100 domain interface; other site 216596023101 Pfam match to entry PF01493.6 GXGXG 216596023102 Pfam match to entry PF01645.6 Glu_synthase 216596023103 Pfam match to entry PF04898.2 Glu_syn_central 216596023104 Pfam match to entry PF04897.2 Glu_synth_NTN 216596023105 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 216596023106 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 216596023107 tetramer interface [polypeptide binding]; other site 216596023108 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596023109 catalytic residue [active] 216596023110 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596023111 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596023112 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216596023113 dimerization interface [polypeptide binding]; other site 216596023114 Pfam match to entry PF03466.5 LysR_substrate 216596023115 Pfam match to entry PF00126.10 HTH_1 216596023116 atcnnnnnnnnngatnnnnnnnnnnnnnnnnatcnnnnnnnnnaat 216596023117 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 216596023118 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 216596023119 9 probable transmembrane helices predicted at aa 13-35, 45-63, 76-98, 108-127,140-162, 177-199, 212-234, 239-261 and 282-304 216596023120 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 216596023121 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 216596023122 putative dimer interface [polypeptide binding]; other site 216596023123 Pfam match to entry PF00011.8 HSP20 216596023124 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 216596023125 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 216596023126 TAP-like protein; Region: Abhydrolase_4; pfam08386 216596023127 Pfam match to entry PF00561.8 Abhydrolase_1 216596023128 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 216596023129 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 216596023130 active site 216596023131 Pfam match to entry PF00459.10 Inositol_P 216596023132 N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: HutG; COG3741 216596023133 Pfam match to entry PF05013.2 FGase 216596023134 Response regulator receiver domain; Region: Response_reg; pfam00072 216596023135 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596023136 active site 216596023137 phosphorylation site [posttranslational modification] 216596023138 intermolecular recognition site; other site 216596023139 dimerization interface [polypeptide binding]; other site 216596023140 Pfam match to entry PF00072.9 Response_reg 216596023141 1 probable transmembrane helix predicted at aa 7-29 216596023142 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 216596023143 MgtC family; Region: MgtC; pfam02308 216596023144 4 probable transmembrane helices predicted at aa 13-35, 50-72, 85-107 and 127-149 216596023145 Pfam match to entry PF02308.6 MgtC 216596023146 hypothetical protein; Provisional; Region: PRK14013 216596023147 8 probable transmembrane helices predicted at aa 34-56, 61-83, 104-126, 156-175,195-217, 277-299, 320-342 and 347-365 216596023148 Pfam match to entry PF04332.2 DUF475 216596023149 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 216596023150 11 probable transmembrane helices predicted at aa 5-27, 47-69, 95-117, 127-149,156-175, 190-209, 299-321, 341-363, 376-398, 408-430 and 451-473 216596023151 Pfam match to entry PF01970.6 DUF112 216596023152 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 216596023153 4 probable transmembrane helices predicted at aa 15-37, 48-70, 85-107 and 127-149 216596023154 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 216596023155 Pfam match to entry PF03401.3 Bug 216596023156 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 216596023157 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 216596023158 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 216596023159 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 216596023160 Pfam match to entry PF02729.5 OTCace_N 216596023161 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 216596023162 cyclase homology domain; Region: CHD; cd07302 216596023163 nucleotidyl binding site; other site 216596023164 metal binding site [ion binding]; metal-binding site 216596023165 dimer interface [polypeptide binding]; other site 216596023166 Predicted integral membrane protein [Function unknown]; Region: COG5616 216596023167 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 216596023168 TPR repeat; Region: TPR_11; pfam13414 216596023169 TPR motif; other site 216596023170 binding surface 216596023171 Pfam match to entry PF00211.9 Guanylate_cyc 216596023172 Pfam match to entry PF00515.11 TPR 216596023173 Pfam match to entry PF00515.11 TPR 216596023174 Pfam match to entry PF00515.11 TPR 216596023175 Pfam match to entry PF00515.11 TPR 216596023176 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 216596023177 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596023178 active site 216596023179 phosphorylation site [posttranslational modification] 216596023180 intermolecular recognition site; other site 216596023181 dimerization interface [polypeptide binding]; other site 216596023182 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216596023183 DNA binding site [nucleotide binding] 216596023184 Pfam match to entry PF00072.9 Response_reg 216596023185 Pfam match to entry PF00486.11 Trans_reg_C 216596023186 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 216596023187 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 216596023188 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216596023189 dimer interface [polypeptide binding]; other site 216596023190 phosphorylation site [posttranslational modification] 216596023191 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596023192 ATP binding site [chemical binding]; other site 216596023193 Mg2+ binding site [ion binding]; other site 216596023194 G-X-G motif; other site 216596023195 1 probable transmembrane helix predicted at aa 166-188 216596023196 Pfam match to entry PF00672.10 HAMP 216596023197 Pfam match to entry PF00512.10 HisKA 216596023198 Pfam match to entry PF02518.9 HATPase_c 216596023199 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 216596023200 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 216596023201 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 216596023202 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 216596023203 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 216596023204 Pfam match to entry PF01841.6 Transglut_core 216596023205 Uncharacterized conserved protein [Function unknown]; Region: COG2308 216596023206 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 216596023207 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 216596023208 Pfam match to entry PF04169.2 DUF404 216596023209 Pfam match to entry PF04174.2 DUF407 216596023210 Pfam match to entry PF04168.2 DUF403 216596023211 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 216596023212 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 216596023213 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 216596023214 Pfam match to entry PF01841.6 Transglut_core 216596023215 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 216596023216 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 216596023217 von Willebrand factor type A domain; Region: VWA_2; pfam13519 216596023218 metal ion-dependent adhesion site (MIDAS); other site 216596023219 1 probable transmembrane helix predicted at aa 21-43 216596023220 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 216596023221 homodimer interface [polypeptide binding]; other site 216596023222 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 216596023223 active site pocket [active] 216596023224 Pfam match to entry PF00343.8 Phosphorylase 216596023225 glycogen branching enzyme; Provisional; Region: PRK05402 216596023226 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 216596023227 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 216596023228 active site 216596023229 catalytic site [active] 216596023230 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 216596023231 Pfam match to entry PF02922.6 Isoamylase_N 216596023232 Pfam match to entry PF00128.11 Alpha-amylase 216596023233 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 216596023234 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 216596023235 ligand binding site; other site 216596023236 oligomer interface; other site 216596023237 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 216596023238 dimer interface [polypeptide binding]; other site 216596023239 N-terminal domain interface [polypeptide binding]; other site 216596023240 sulfate 1 binding site; other site 216596023241 Pfam match to entry PF00483.9 NTP_transferase 216596023242 glycogen synthase; Provisional; Region: glgA; PRK00654 216596023243 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 216596023244 ADP-binding pocket [chemical binding]; other site 216596023245 homodimer interface [polypeptide binding]; other site 216596023246 Pfam match to entry PF00534.8 Glycos_transf_1 216596023247 phosphoglucomutase; Region: PLN02307 216596023248 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 216596023249 substrate binding site [chemical binding]; other site 216596023250 dimer interface [polypeptide binding]; other site 216596023251 active site 216596023252 metal binding site [ion binding]; metal-binding site 216596023253 Pfam match to entry PF02878.5 PGM_PMM_I 216596023254 Pfam match to entry PF02879.5 PGM_PMM_II 216596023255 Pfam match to entry PF02880.5 PGM_PMM_III 216596023256 Pfam match to entry PF00408.9 PGM_PMM_IV 216596023257 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 216596023258 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 216596023259 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 216596023260 active site 216596023261 catalytic site [active] 216596023262 Pfam match to entry PF02922.6 Isoamylase_N 216596023263 Pfam match to entry PF00128.11 Alpha-amylase 216596023264 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 216596023265 putative active site [active] 216596023266 putative catalytic site [active] 216596023267 Pfam match to entry PF01575.6 MaoC_dehydratas 216596023268 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216596023269 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 216596023270 Pfam match to entry PF00903.11 Glyoxalase 216596023271 Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583 216596023272 Pfam match to entry PF04268.2 SoxG 216596023273 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 216596023274 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 216596023275 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 216596023276 Pfam match to entry PF01571.8 GCV_T 216596023277 Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311 216596023278 Pfam match to entry PF04267.2 SoxD 216596023279 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 216596023280 hydroxyglutarate oxidase; Provisional; Region: PRK11728 216596023281 Pfam match to entry PF01266.8 DAO 216596023282 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4254 216596023283 FecR protein; Region: FecR; pfam04773 216596023284 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 216596023285 CHASE2 domain; Region: CHASE2; pfam05226 216596023286 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 216596023287 cyclase homology domain; Region: CHD; cd07302 216596023288 nucleotidyl binding site; other site 216596023289 metal binding site [ion binding]; metal-binding site 216596023290 dimer interface [polypeptide binding]; other site 216596023291 Pfam match to entry PF00211.9 Guanylate_cyc 216596023292 4 probable transmembrane helices predicted at aa 21-40, 363-385, 392-414 and 419-441 216596023293 Pfam match to entry PF05226.1 CHASE2 216596023294 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 216596023295 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 216596023296 cyclase homology domain; Region: CHD; cd07302 216596023297 nucleotidyl binding site; other site 216596023298 metal binding site [ion binding]; metal-binding site 216596023299 dimer interface [polypeptide binding]; other site 216596023300 2 probable transmembrane helices predicted at aa 12-34 and 211-233 216596023301 Pfam match to entry PF00211.9 Guanylate_cyc 216596023302 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 216596023303 Pfam match to entry PF01165.7 Ribosomal_S21 216596023304 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216596023305 TPR motif; other site 216596023306 TPR repeat; Region: TPR_11; pfam13414 216596023307 binding surface 216596023308 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216596023309 binding surface 216596023310 TPR repeat; Region: TPR_11; pfam13414 216596023311 TPR motif; other site 216596023312 TPR repeat; Region: TPR_11; pfam13414 216596023313 Tetratricopeptide repeat; Region: TPR_12; pfam13424 216596023314 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216596023315 binding surface 216596023316 TPR motif; other site 216596023317 Pfam match to entry PF00515.11 TPR 216596023318 Pfam match to entry PF00515.11 TPR 216596023319 Pfam match to entry PF00515.11 TPR 216596023320 Pfam match to entry PF00515.11 TPR 216596023321 Pfam match to entry PF00515.11 TPR 216596023322 Pfam match to entry PF00515.11 TPR 216596023323 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 216596023324 HWE histidine kinase; Region: HWE_HK; smart00911 216596023325 1 probable transmembrane helix predicted at aa 256-278 216596023326 Pfam match to entry PF00672.10 HAMP 216596023327 Pfam match to entry PF07536.2 HWE_HK 216596023328 Protein of unknown function (DUF992); Region: DUF992; pfam06186 216596023329 Pfam match to entry PF06186.1 DUF992 216596023330 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 216596023331 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 216596023332 Pfam match to entry PF02233.5 PNTB 216596023333 8 probable transmembrane helices predicted at aa 7-24, 34-52, 57-79, 94-116,129-148, 163-185, 192-212 and 227-249 216596023334 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 216596023335 3 probable transmembrane helices predicted at aa 41-63, 70-92 and 97-119 216596023336 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 216596023337 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 216596023338 ligand binding site [chemical binding]; other site 216596023339 homodimer interface [polypeptide binding]; other site 216596023340 NAD(P) binding site [chemical binding]; other site 216596023341 trimer interface B [polypeptide binding]; other site 216596023342 trimer interface A [polypeptide binding]; other site 216596023343 Pfam match to entry PF01262.8 AlaDh_PNT_C 216596023344 Pfam match to entry PF05222.2 AlaDh_PNT_N 216596023345 Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835 216596023346 2 probable transmembrane helices predicted at aa 61-83 and 88-107 216596023347 PAS domain; Region: PAS; smart00091 216596023348 PAS fold; Region: PAS_7; pfam12860 216596023349 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 216596023350 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216596023351 metal binding site [ion binding]; metal-binding site 216596023352 active site 216596023353 I-site; other site 216596023354 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216596023355 Pfam match to entry PF00563.9 EAL 216596023356 Pfam match to entry PF00990.8 GGDEF 216596023357 Pfam match to entry PF00989.11 PAS 216596023358 5 probable transmembrane helices predicted at aa 21-43, 47-69, 91-113, 117-136 and 157-179 216596023359 TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665 216596023360 4 probable transmembrane helices predicted at aa 21-43, 53-70, 96-118 and 133-155 216596023361 Pfam match to entry PF04290.2 DctQ 216596023362 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 216596023363 DctM-like transporters; Region: DctM; pfam06808 216596023364 12 probable transmembrane helices predicted at aa 15-37, 58-80, 106-128, 149-171,181-203, 222-244, 248-270, 291-310, 325-347, 352-374,384-401 and 414-436 216596023365 Pfam match to entry PF06808.1 DctM 216596023366 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 216596023367 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 216596023368 Pfam match to entry PF03480.3 SBP_bac_7 216596023369 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 216596023370 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 216596023371 catalytic triad [active] 216596023372 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 216596023373 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 216596023374 putative ligand binding site [chemical binding]; other site 216596023375 NAD binding site [chemical binding]; other site 216596023376 catalytic site [active] 216596023377 Pfam match to entry PF02826.5 2-Hacid_dh_C 216596023378 Pfam match to entry PF00389.14 2-Hacid_dh 216596023379 Transcriptional regulators [Transcription]; Region: PurR; COG1609 216596023380 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216596023381 DNA binding site [nucleotide binding] 216596023382 domain linker motif; other site 216596023383 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 216596023384 putative dimerization interface [polypeptide binding]; other site 216596023385 putative ligand binding site [chemical binding]; other site 216596023386 Pfam match to entry PF00532.8 Peripla_BP_1 216596023387 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 216596023388 MarR family; Region: MarR; pfam01047 216596023389 Pfam match to entry PF01047.8 MarR 216596023390 Creatinine amidohydrolase; Region: Creatininase; pfam02633 216596023391 Pfam match to entry PF02633.4 Creatininase 216596023392 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 216596023393 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 216596023394 P-loop, Walker A motif; other site 216596023395 Base recognition motif; other site 216596023396 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 216596023397 Pfam match to entry PF02492.6 cobW 216596023398 FOG: WD40 repeat [General function prediction only]; Region: COG2319 216596023399 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 216596023400 structural tetrad; other site 216596023401 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 216596023402 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216596023403 Coenzyme A binding pocket [chemical binding]; other site 216596023404 Pfam match to entry PF00583.9 Acetyltransf_1 216596023405 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 216596023406 Transposase domain (DUF772); Region: DUF772; pfam05598 216596023407 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 216596023408 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 216596023409 Pfam match to entry PF01609.9 Transposase_11 216596023410 serine acetyltransferase; Provisional; Region: cysE; PRK11132 216596023411 Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971 216596023412 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 216596023413 trimer interface [polypeptide binding]; other site 216596023414 active site 216596023415 substrate binding site [chemical binding]; other site 216596023416 CoA binding site [chemical binding]; other site 216596023417 Pfam match to entry PF06426.1 SATase_N 216596023418 Pfam match to entry PF00132.9 Hexapep 216596023419 Pfam match to entry PF00132.9 Hexapep 216596023420 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 216596023421 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216596023422 metal binding site [ion binding]; metal-binding site 216596023423 active site 216596023424 I-site; other site 216596023425 Pfam match to entry PF00990.8 GGDEF 216596023426 7 probable transmembrane helices predicted at aa 5-27, 36-55, 70-87, 94-111,121-143, 150-172 and 187-209 216596023427 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 216596023428 Beta-lactamase; Region: Beta-lactamase; pfam00144 216596023429 Pfam match to entry PF00144.9 Beta-lactamase 216596023430 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216596023431 Coenzyme A binding pocket [chemical binding]; other site 216596023432 Pfam match to entry PF00583.9 Acetyltransf_1 216596023433 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 216596023434 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 216596023435 active site 216596023436 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 216596023437 dimer interface [polypeptide binding]; other site 216596023438 catalytic residues [active] 216596023439 substrate binding site [chemical binding]; other site 216596023440 Pfam match to entry PF00278.10 Orn_DAP_Arg_deC 216596023441 Pfam match to entry PF02784.5 Orn_Arg_deC_N 216596023442 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596023443 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596023444 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 216596023445 putative effector binding pocket; other site 216596023446 dimerization interface [polypeptide binding]; other site 216596023447 Pfam match to entry PF00126.10 HTH_1 216596023448 Pfam match to entry PF03466.5 LysR_substrate 216596023449 Protein of unknown function (DUF1007); Region: DUF1007; pfam06226 216596023450 Pfam match to entry PF06226.1 DUF1007 216596023451 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 216596023452 7 probable transmembrane helices predicted at aa 7-26, 75-97, 118-140, 155-174,259-281, 286-308 and 329-351 216596023453 Pfam match to entry PF03824.5 NicO 216596023454 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 216596023455 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 216596023456 Pfam match to entry PF00583.9 Acetyltransf_1 216596023457 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 216596023458 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 216596023459 putative metal binding site [ion binding]; other site 216596023460 Pfam match to entry PF04391.2 DUF533 216596023461 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 216596023462 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 216596023463 active site 216596023464 intersubunit interface [polypeptide binding]; other site 216596023465 catalytic residue [active] 216596023466 Pfam match to entry PF01081.7 Aldolase 216596023467 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 216596023468 putative active site [active] 216596023469 putative metal binding residues [ion binding]; other site 216596023470 signature motif; other site 216596023471 putative dimer interface [polypeptide binding]; other site 216596023472 putative phosphate binding site [ion binding]; other site 216596023473 Pfam match to entry PF01928.10 CYTH 216596023474 CHAD domain; Region: CHAD; pfam05235 216596023475 Pfam match to entry PF05235.2 CHAD 216596023476 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 216596023477 active site 216596023478 metal binding site [ion binding]; metal-binding site 216596023479 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216596023480 Pfam match to entry PF00903.11 Glyoxalase 216596023481 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 216596023482 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 216596023483 active site residue [active] 216596023484 Pfam match to entry PF00581.7 Rhodanese 216596023485 CHASE4 domain; Region: CHASE4; pfam05228 216596023486 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 216596023487 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216596023488 metal binding site [ion binding]; metal-binding site 216596023489 active site 216596023490 I-site; other site 216596023491 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216596023492 Pfam match to entry PF00563.9 EAL 216596023493 Pfam match to entry PF00990.8 GGDEF 216596023494 2 probable transmembrane helices predicted at aa 20-42 and 267-289 216596023495 Pfam match to entry PF05228.1 CHASE4 216596023496 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 216596023497 beta-galactosidase; Region: BGL; TIGR03356 216596023498 Pfam match to entry PF00232.8 Glyco_hydro_1 216596023499 Predicted membrane protein [Function unknown]; Region: COG2259 216596023500 Pfam match to entry PF04173.2 DoxD 216596023501 3 probable transmembrane helices predicted at aa 70-92, 99-121 and 126-148 216596023502 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 216596023503 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 216596023504 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 216596023505 Pfam match to entry PF02894.4 GFO_IDH_MocA_C 216596023506 Pfam match to entry PF01408.8 GFO_IDH_MocA 216596023507 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 216596023508 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 216596023509 AP (apurinic/apyrimidinic) site pocket; other site 216596023510 DNA interaction; other site 216596023511 Metal-binding active site; metal-binding site 216596023512 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 216596023513 Pfam match to entry PF07582.1 AP_endonuc_2_N 216596023514 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 216596023515 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_3; cd06311 216596023516 putative ligand binding site [chemical binding]; other site 216596023517 Pfam match to entry PF00532.8 Peripla_BP_1 216596023518 Signal peptide predicted for RL4172 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 33 and 34 216596023519 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596023520 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216596023521 TM-ABC transporter signature motif; other site 216596023522 9 probable transmembrane helices predicted at aa 24-46, 53-75, 79-101, 108-130,180-202, 233-250, 260-279, 286-305 and 309-328 216596023523 Pfam match to entry PF02653.5 BPD_transp_2 216596023524 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 216596023525 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 216596023526 Walker A/P-loop; other site 216596023527 ATP binding site [chemical binding]; other site 216596023528 Q-loop/lid; other site 216596023529 ABC transporter signature motif; other site 216596023530 Walker B; other site 216596023531 D-loop; other site 216596023532 H-loop/switch region; other site 216596023533 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 216596023534 Pfam match to entry PF00005.11 ABC_tran 216596023535 Pfam match to entry PF00005.11 ABC_tran 216596023536 Transcriptional regulators [Transcription]; Region: PurR; COG1609 216596023537 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216596023538 DNA binding site [nucleotide binding] 216596023539 domain linker motif; other site 216596023540 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 216596023541 dimerization interface [polypeptide binding]; other site 216596023542 ligand binding site [chemical binding]; other site 216596023543 Pfam match to entry PF00356.8 LacI 216596023544 Pfam match to entry PF00532.8 Peripla_BP_1 216596023545 xylose isomerase; Provisional; Region: PRK05474 216596023546 xylose isomerase; Region: xylose_isom_A; TIGR02630 216596023547 Pfam match to entry PF00259.7 Xylose_isom 216596023548 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 216596023549 N- and C-terminal domain interface [polypeptide binding]; other site 216596023550 D-xylulose kinase; Region: XylB; TIGR01312 216596023551 active site 216596023552 MgATP binding site [chemical binding]; other site 216596023553 catalytic site [active] 216596023554 metal binding site [ion binding]; metal-binding site 216596023555 xylulose binding site [chemical binding]; other site 216596023556 homodimer interface [polypeptide binding]; other site 216596023557 Pfam match to entry PF02782.4 FGGY_C 216596023558 Pfam match to entry PF00370.9 FGGY_N 216596023559 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216596023560 DNA binding site [nucleotide binding] 216596023561 domain linker motif; other site 216596023562 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 216596023563 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 216596023564 putative ligand binding site [chemical binding]; other site 216596023565 Pfam match to entry PF00532.8 Peripla_BP_1 216596023566 Pfam match to entry PF00356.8 LacI 216596023567 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 216596023568 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596023569 putative substrate translocation pore; other site 216596023570 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596023571 11 probable transmembrane helices predicted at aa 28-50, 90-112, 121-143, 153-175,182-204, 219-236, 248-270, 290-312, 351-370, 380-402 and 493-515 216596023572 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 216596023573 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 216596023574 HlyD family secretion protein; Region: HlyD_3; pfam13437 216596023575 Pfam match to entry PF00529.8 HlyD 216596023576 1 probable transmembrane helix predicted at aa 64-81 216596023577 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216596023578 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216596023579 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 216596023580 Pfam match to entry PF00440.8 TetR_N 216596023581 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216596023582 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216596023583 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216596023584 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 216596023585 Pfam match to entry PF00165.8 HTH_AraC 216596023586 Pfam match to entry PF00165.8 HTH_AraC 216596023587 Pfam match to entry PF06445.1 AraC_E_bind 216596023588 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 216596023589 7 probable transmembrane helices predicted at aa 10-32, 49-71, 81-99, 126-148,158-180, 187-209 and 214-233 216596023590 Pfam match to entry PF03741.3 TerC 216596023591 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 216596023592 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 216596023593 HIGH motif; other site 216596023594 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 216596023595 active site 216596023596 KMSKS motif; other site 216596023597 Pfam match to entry PF00749.9 tRNA-synt_1c 216596023598 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 216596023599 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 216596023600 dimer interface [polypeptide binding]; other site 216596023601 putative anticodon binding site; other site 216596023602 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 216596023603 motif 1; other site 216596023604 active site 216596023605 motif 2; other site 216596023606 motif 3; other site 216596023607 Pfam match to entry PF01336.9 tRNA_anti 216596023608 Pfam match to entry PF00152.8 tRNA-synt_2 216596023609 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 216596023610 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216596023611 NAD(P) binding site [chemical binding]; other site 216596023612 active site 216596023613 Pfam match to entry PF00106.11 adh_short 216596023614 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 216596023615 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 216596023616 Pfam match to entry PF06719.1 AraC_N 216596023617 Pfam match to entry PF00165.8 HTH_AraC 216596023618 Pfam match to entry PF00165.8 HTH_AraC 216596023619 1 probable transmembrane helix predicted at aa 13-35 216596023620 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596023621 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596023622 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 216596023623 putative substrate binding pocket [chemical binding]; other site 216596023624 dimerization interface [polypeptide binding]; other site 216596023625 Pfam match to entry PF00126.10 HTH_1 216596023626 Pfam match to entry PF03466.5 LysR_substrate 216596023627 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 216596023628 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 216596023629 Pfam match to entry PF01547.11 SBP_bac_1 216596023630 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 216596023631 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216596023632 Walker A/P-loop; other site 216596023633 ATP binding site [chemical binding]; other site 216596023634 Q-loop/lid; other site 216596023635 ABC transporter signature motif; other site 216596023636 Walker B; other site 216596023637 D-loop; other site 216596023638 H-loop/switch region; other site 216596023639 TOBE domain; Region: TOBE_2; pfam08402 216596023640 Pfam match to entry PF00005.11 ABC_tran 216596023641 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 216596023642 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596023643 dimer interface [polypeptide binding]; other site 216596023644 conserved gate region; other site 216596023645 putative PBP binding loops; other site 216596023646 ABC-ATPase subunit interface; other site 216596023647 6 probable transmembrane helices predicted at aa 35-57, 94-116, 129-151, 182-204,240-262 and 290-312 216596023648 Pfam match to entry PF00528.10 BPD_transp_1 216596023649 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 216596023650 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596023651 dimer interface [polypeptide binding]; other site 216596023652 conserved gate region; other site 216596023653 putative PBP binding loops; other site 216596023654 ABC-ATPase subunit interface; other site 216596023655 5 probable transmembrane helices predicted at aa 13-35, 69-91, 103-122, 132-151 and 236-258 216596023656 Pfam match to entry PF00528.10 BPD_transp_1 216596023657 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 216596023658 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 216596023659 tetrameric interface [polypeptide binding]; other site 216596023660 NAD binding site [chemical binding]; other site 216596023661 catalytic residues [active] 216596023662 substrate binding site [chemical binding]; other site 216596023663 Pfam match to entry PF00171.9 Aldedh 216596023664 hypothetical protein; Provisional; Region: PRK13682 216596023665 2 probable transmembrane helices predicted at aa 15-37 and 44-66 216596023666 Pfam match to entry PF07043.1 DUF1328 216596023667 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 216596023668 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 216596023669 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 216596023670 dimerization interface [polypeptide binding]; other site 216596023671 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216596023672 dimer interface [polypeptide binding]; other site 216596023673 phosphorylation site [posttranslational modification] 216596023674 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596023675 ATP binding site [chemical binding]; other site 216596023676 Mg2+ binding site [ion binding]; other site 216596023677 G-X-G motif; other site 216596023678 Pfam match to entry PF02518.9 HATPase_c 216596023679 Pfam match to entry PF00512.10 HisKA 216596023680 Pfam match to entry PF00672.10 HAMP 216596023681 2 probable transmembrane helices predicted at aa 13-35 and 154-176 216596023682 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 216596023683 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596023684 active site 216596023685 phosphorylation site [posttranslational modification] 216596023686 intermolecular recognition site; other site 216596023687 dimerization interface [polypeptide binding]; other site 216596023688 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216596023689 DNA binding site [nucleotide binding] 216596023690 Pfam match to entry PF00486.11 Trans_reg_C 216596023691 Pfam match to entry PF00072.9 Response_reg 216596023692 Predicted membrane protein [Function unknown]; Region: COG2259 216596023693 Pfam match to entry PF04173.2 DoxD 216596023694 4 probable transmembrane helices predicted at aa 38-60, 75-97, 104-122 and 137-156 216596023695 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 216596023696 Pfam match to entry PF07077.1 DUF1345 216596023697 5 probable transmembrane helices predicted at aa 13-35, 39-61, 82-104, 114-136 and 197-219 216596023698 transaldolase-like protein; Provisional; Region: PTZ00411 216596023699 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 216596023700 active site 216596023701 dimer interface [polypeptide binding]; other site 216596023702 catalytic residue [active] 216596023703 Pfam match to entry PF00923.8 Transaldolase 216596023704 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 216596023705 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 216596023706 DNA binding residues [nucleotide binding] 216596023707 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 216596023708 Pfam match to entry PF04198.2 Sugar-bind 216596023709 Helix-turn-helix domain; Region: HTH_18; pfam12833 216596023710 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 216596023711 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 216596023712 DNA binding site [nucleotide binding] 216596023713 active site 216596023714 Pfam match to entry PF01035.9 Methyltransf_1 216596023715 Pfam match to entry PF00165.8 HTH_AraC 216596023716 Pfam match to entry PF00165.8 HTH_AraC 216596023717 Integral membrane protein [Function unknown]; Region: COG5488 216596023718 2 probable transmembrane helices predicted at aa 32-49 and 53-75 216596023719 Signal peptide predicted for RL4207 by SignalP 2.0 HMM (Signal peptide probabilty 0.900) with cleavage site probability 0.886 between residues 19 and 20 216596023720 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 216596023721 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 216596023722 minor groove reading motif; other site 216596023723 helix-hairpin-helix signature motif; other site 216596023724 substrate binding pocket [chemical binding]; other site 216596023725 active site 216596023726 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 216596023727 Pfam match to entry PF00730.11 HhH-GPD 216596023728 Pfam match to entry PF00633.11 HHH 216596023729 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216596023730 Pfam match to entry PF00440.8 TetR_N 216596023731 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 216596023732 putative dimer interface [polypeptide binding]; other site 216596023733 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216596023734 Pfam match to entry PF00903.11 Glyoxalase 216596023735 CysZ-like protein; Reviewed; Region: PRK12768 216596023736 Pfam match to entry PF04401.2 DUF540 216596023737 4 probable transmembrane helices predicted at aa 21-43, 63-85, 135-157 and 190-212 216596023738 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 216596023739 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 216596023740 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 216596023741 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 216596023742 N- and C-terminal domain interface [polypeptide binding]; other site 216596023743 active site 216596023744 MgATP binding site [chemical binding]; other site 216596023745 catalytic site [active] 216596023746 metal binding site [ion binding]; metal-binding site 216596023747 carbohydrate binding site [chemical binding]; other site 216596023748 putative homodimer interface [polypeptide binding]; other site 216596023749 Pfam match to entry PF02782.4 FGGY_C 216596023750 Pfam match to entry PF00370.9 FGGY_N 216596023751 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 216596023752 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216596023753 motif II; other site 216596023754 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 216596023755 Pfam match to entry PF00702.10 Hydrolase 216596023756 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 216596023757 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 216596023758 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 216596023759 Pfam match to entry PF01232.10 Mannitol_dh 216596023760 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 216596023761 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 216596023762 Walker A/P-loop; other site 216596023763 ATP binding site [chemical binding]; other site 216596023764 Q-loop/lid; other site 216596023765 ABC transporter signature motif; other site 216596023766 Walker B; other site 216596023767 D-loop; other site 216596023768 H-loop/switch region; other site 216596023769 TOBE domain; Region: TOBE_2; pfam08402 216596023770 Pfam match to entry PF03459.4 TOBE 216596023771 Pfam match to entry PF00005.11 ABC_tran 216596023772 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216596023773 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596023774 dimer interface [polypeptide binding]; other site 216596023775 conserved gate region; other site 216596023776 putative PBP binding loops; other site 216596023777 ABC-ATPase subunit interface; other site 216596023778 Pfam match to entry PF00528.10 BPD_transp_1 216596023779 6 probable transmembrane helices predicted at aa 12-34, 75-97, 109-131, 141-163,185-207 and 239-261 216596023780 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596023781 dimer interface [polypeptide binding]; other site 216596023782 conserved gate region; other site 216596023783 putative PBP binding loops; other site 216596023784 ABC-ATPase subunit interface; other site 216596023785 Pfam match to entry PF00528.10 BPD_transp_1 216596023786 6 probable transmembrane helices predicted at aa 45-67, 101-123, 130-152, 185-207,240-262 and 288-310 216596023787 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 216596023788 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 216596023789 Pfam match to entry PF01547.11 SBP_bac_1 216596023790 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 216596023791 MarR family; Region: MarR_2; pfam12802 216596023792 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 216596023793 Pfam match to entry PF04198.2 Sugar-bind 216596023794 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 216596023795 Pfam match to entry PF06055.1 ExoD 216596023796 3 probable transmembrane helices predicted at aa 18-40, 91-113 and 128-150 216596023797 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 216596023798 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 216596023799 nucleotide binding site [chemical binding]; other site 216596023800 Pfam match to entry PF00480.8 ROK 216596023801 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 216596023802 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 216596023803 active site 216596023804 Pfam match to entry PF00728.9 Glyco_hydro_20 216596023805 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 216596023806 12 probable transmembrane helices predicted at aa 21-43, 347-364, 369-391, 396-415,435-457, 472-494, 527-549, 862-884, 891-910, 915-937,958-980 and 995-1017 216596023807 Pfam match to entry PF00873.7 ACR_tran 216596023808 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 216596023809 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 216596023810 HlyD family secretion protein; Region: HlyD_3; pfam13437 216596023811 Pfam match to entry PF00529.8 HlyD 216596023812 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216596023813 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216596023814 Pfam match to entry PF00440.8 TetR_N 216596023815 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 216596023816 Pfam match to entry PF02566.5 OsmC 216596023817 short chain dehydrogenase; Provisional; Region: PRK07063 216596023818 classical (c) SDRs; Region: SDR_c; cd05233 216596023819 NAD(P) binding site [chemical binding]; other site 216596023820 active site 216596023821 Pfam match to entry PF00106.11 adh_short 216596023822 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 216596023823 active site 216596023824 catalytic residues [active] 216596023825 Pfam match to entry PF01263.8 Aldose_epim 216596023826 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596023827 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216596023828 TM-ABC transporter signature motif; other site 216596023829 9 probable transmembrane helices predicted at aa 7-29, 39-61, 66-85, 89-111,118-137, 157-179, 209-231, 253-275 and 282-304 216596023830 Pfam match to entry PF02653.5 BPD_transp_2 216596023831 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 216596023832 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 216596023833 Walker A/P-loop; other site 216596023834 ATP binding site [chemical binding]; other site 216596023835 Q-loop/lid; other site 216596023836 ABC transporter signature motif; other site 216596023837 Walker B; other site 216596023838 D-loop; other site 216596023839 H-loop/switch region; other site 216596023840 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 216596023841 Pfam match to entry PF00005.11 ABC_tran 216596023842 Pfam match to entry PF00005.11 ABC_tran 216596023843 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 216596023844 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 216596023845 ligand binding site [chemical binding]; other site 216596023846 Pfam match to entry PF00532.8 Peripla_BP_1 216596023847 1 probable transmembrane helix predicted at aa 30-52 216596023848 Transcriptional regulators [Transcription]; Region: FadR; COG2186 216596023849 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596023850 DNA-binding site [nucleotide binding]; DNA binding site 216596023851 FCD domain; Region: FCD; pfam07729 216596023852 Pfam match to entry PF00392.9 GntR 216596023853 galactonate dehydratase; Provisional; Region: PRK14017 216596023854 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 216596023855 putative active site pocket [active] 216596023856 putative metal binding site [ion binding]; other site 216596023857 Pfam match to entry PF02746.4 MR_MLE_N 216596023858 Pfam match to entry PF01188.9 MR_MLE 216596023859 Pfam match to entry PF04173.2 DoxD 216596023860 4 probable transmembrane helices predicted at aa 7-24, 34-53, 60-82 and 97-119 216596023861 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 216596023862 classical (c) SDRs; Region: SDR_c; cd05233 216596023863 NAD(P) binding site [chemical binding]; other site 216596023864 active site 216596023865 Pfam match to entry PF00106.11 adh_short 216596023866 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 216596023867 cyclase homology domain; Region: CHD; cd07302 216596023868 nucleotidyl binding site; other site 216596023869 metal binding site [ion binding]; metal-binding site 216596023870 dimer interface [polypeptide binding]; other site 216596023871 Pfam match to entry PF00211.9 Guanylate_cyc 216596023872 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 216596023873 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216596023874 DNA binding site [nucleotide binding] 216596023875 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 216596023876 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 216596023877 Pfam match to entry PF05721.2 PhyH 216596023878 short chain dehydrogenase; Provisional; Region: PRK06198 216596023879 classical (c) SDRs; Region: SDR_c; cd05233 216596023880 NAD(P) binding site [chemical binding]; other site 216596023881 active site 216596023882 Pfam match to entry PF00106.11 adh_short 216596023883 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 216596023884 Pfam match to entry PF03758.3 SMP-30 216596023885 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 216596023886 conserved cys residue [active] 216596023887 Pfam match to entry PF06283.1 DUF1037 216596023888 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 216596023889 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 216596023890 Walker A/P-loop; other site 216596023891 ATP binding site [chemical binding]; other site 216596023892 Q-loop/lid; other site 216596023893 ABC transporter signature motif; other site 216596023894 Walker B; other site 216596023895 D-loop; other site 216596023896 H-loop/switch region; other site 216596023897 TOBE domain; Region: TOBE_2; pfam08402 216596023898 Pfam match to entry PF03459.4 TOBE 216596023899 Pfam match to entry PF00005.11 ABC_tran 216596023900 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216596023901 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596023902 dimer interface [polypeptide binding]; other site 216596023903 conserved gate region; other site 216596023904 putative PBP binding loops; other site 216596023905 ABC-ATPase subunit interface; other site 216596023906 Pfam match to entry PF00528.10 BPD_transp_1 216596023907 6 probable transmembrane helices predicted at aa 17-39, 73-95, 108-130, 161-183,213-235 and 266-288 216596023908 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596023909 dimer interface [polypeptide binding]; other site 216596023910 conserved gate region; other site 216596023911 putative PBP binding loops; other site 216596023912 ABC-ATPase subunit interface; other site 216596023913 Pfam match to entry PF00528.10 BPD_transp_1 216596023914 6 probable transmembrane helices predicted at aa 13-35, 75-97, 110-132, 147-169,218-240 and 266-288 216596023915 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 216596023916 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 216596023917 Pfam match to entry PF01547.11 SBP_bac_1 216596023918 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 216596023919 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 216596023920 Pfam match to entry PF01408.8 GFO_IDH_MocA 216596023921 Pfam match to entry PF02894.4 GFO_IDH_MocA_C 216596023922 Transcriptional regulators [Transcription]; Region: PurR; COG1609 216596023923 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216596023924 DNA binding site [nucleotide binding] 216596023925 domain linker motif; other site 216596023926 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 216596023927 Pfam match to entry PF00532.8 Peripla_BP_1 216596023928 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 216596023929 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 216596023930 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 216596023931 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 216596023932 Pfam match to entry PF02837.6 Glyco_hydro_2_N 216596023933 Pfam match to entry PF00703.9 Glyco_hydro_2 216596023934 Pfam match to entry PF02836.5 Glyco_hydro_2_C 216596023935 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 216596023936 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 216596023937 Walker A/P-loop; other site 216596023938 ATP binding site [chemical binding]; other site 216596023939 Q-loop/lid; other site 216596023940 ABC transporter signature motif; other site 216596023941 Walker B; other site 216596023942 D-loop; other site 216596023943 H-loop/switch region; other site 216596023944 Pfam match to entry PF03459.4 TOBE 216596023945 Pfam match to entry PF00005.11 ABC_tran 216596023946 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216596023947 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596023948 dimer interface [polypeptide binding]; other site 216596023949 conserved gate region; other site 216596023950 putative PBP binding loops; other site 216596023951 ABC-ATPase subunit interface; other site 216596023952 Pfam match to entry PF00528.10 BPD_transp_1 216596023953 6 probable transmembrane helices predicted at aa 20-42, 97-116, 128-150, 175-197,218-240 and 282-304 216596023954 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 216596023955 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596023956 dimer interface [polypeptide binding]; other site 216596023957 putative PBP binding loops; other site 216596023958 ABC-ATPase subunit interface; other site 216596023959 Pfam match to entry PF00528.10 BPD_transp_1 216596023960 6 probable transmembrane helices predicted at aa 32-54, 97-119, 132-151, 181-203,232-251 and 287-309 216596023961 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 216596023962 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 216596023963 Pfam match to entry PF01547.11 SBP_bac_1 216596023964 Transcriptional regulators [Transcription]; Region: PurR; COG1609 216596023965 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216596023966 DNA binding site [nucleotide binding] 216596023967 domain linker motif; other site 216596023968 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 216596023969 ligand binding site [chemical binding]; other site 216596023970 Pfam match to entry PF00532.8 Peripla_BP_1 216596023971 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 216596023972 Ligand Binding Site [chemical binding]; other site 216596023973 Pfam match to entry PF06508.1 ExsB 216596023974 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 216596023975 active site 216596023976 Pfam match to entry PF01242.8 PTPS 216596023977 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 216596023978 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 216596023979 Pfam match to entry PF04055.4 Radical_SAM 216596023980 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 216596023981 cyclase homology domain; Region: CHD; cd07302 216596023982 nucleotidyl binding site; other site 216596023983 metal binding site [ion binding]; metal-binding site 216596023984 dimer interface [polypeptide binding]; other site 216596023985 Pfam match to entry PF00211.9 Guanylate_cyc 216596023986 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 216596023987 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 216596023988 dimer interface [polypeptide binding]; other site 216596023989 putative radical transfer pathway; other site 216596023990 diiron center [ion binding]; other site 216596023991 tyrosyl radical; other site 216596023992 Pfam match to entry PF00268.10 Ribonuc_red_sm 216596023993 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 216596023994 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 216596023995 Class I ribonucleotide reductase; Region: RNR_I; cd01679 216596023996 active site 216596023997 dimer interface [polypeptide binding]; other site 216596023998 catalytic residues [active] 216596023999 effector binding site; other site 216596024000 R2 peptide binding site; other site 216596024001 Pfam match to entry PF02867.4 Ribonuc_red_lgC 216596024002 Pfam match to entry PF00317.10 Ribonuc_red_lgN 216596024003 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 216596024004 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 216596024005 catalytic residues [active] 216596024006 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 216596024007 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 216596024008 metal-binding site [ion binding] 216596024009 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 216596024010 6 probable transmembrane helices predicted at aa 154-176, 191-213, 368-390,405-427, 704-726 and 730-752 216596024011 Pfam match to entry PF00702.10 Hydrolase 216596024012 Pfam match to entry PF00122.7 E1-E2_ATPase 216596024013 Pfam match to entry PF00403.12 HMA 216596024014 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 216596024015 DNA binding residues [nucleotide binding] 216596024016 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 216596024017 dimer interface [polypeptide binding]; other site 216596024018 putative metal binding site [ion binding]; other site 216596024019 Pfam match to entry PF00376.9 MerR 216596024020 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 216596024021 Pfam match to entry PF03486.3 HI0933_like 216596024022 methionine sulfoxide reductase B; Provisional; Region: PRK00222 216596024023 SelR domain; Region: SelR; pfam01641 216596024024 Pfam match to entry PF01641.7 SelR 216596024025 1 probable transmembrane helix predicted at aa 7-29 216596024026 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 216596024027 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 216596024028 Pfam match to entry PF01590.11 GAF 216596024029 Pfam match to entry PF02954.7 HTH_8 216596024030 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 216596024031 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 216596024032 NAD(P) binding site [chemical binding]; other site 216596024033 catalytic residues [active] 216596024034 Pfam match to entry PF00171.9 Aldedh 216596024035 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3564 216596024036 Pfam match to entry PF05610.1 DUF779 216596024037 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 216596024038 intracellular protease, PfpI family; Region: PfpI; TIGR01382 216596024039 conserved cys residue [active] 216596024040 Pfam match to entry PF01965.9 DJ-1_PfpI 216596024041 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 216596024042 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 216596024043 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216596024044 NAD(P) binding site [chemical binding]; other site 216596024045 active site 216596024046 Pfam match to entry PF00106.11 adh_short 216596024047 1 probable transmembrane helix predicted at aa 209-231 216596024048 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 216596024049 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 216596024050 11 probable transmembrane helices predicted at aa 20-37, 47-69, 82-104, 119-138,150-172, 182-201, 230-252, 262-284, 297-319, 334-353 and 360-375 216596024051 Pfam match to entry PF01699.11 Na_Ca_ex 216596024052 4 probable transmembrane helices predicted at aa 5-24, 36-58, 174-196 and 203-222 216596024053 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 216596024054 HlyD family secretion protein; Region: HlyD_3; pfam13437 216596024055 Pfam match to entry PF00529.8 HlyD 216596024056 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 216596024057 Pfam match to entry PF00873.7 ACR_tran 216596024058 12 probable transmembrane helices predicted at aa 12-34, 344-363, 370-392, 398-420,441-463, 473-491, 537-556, 871-893, 898-920, 930-952,977-999 and 1009-1031 216596024059 Growth hormone receptor binding; Region: GHBP; pfam12772 216596024060 1 probable transmembrane helix predicted at aa 20-42 216596024061 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 216596024062 dimerization interface [polypeptide binding]; other site 216596024063 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 216596024064 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 216596024065 dimer interface [polypeptide binding]; other site 216596024066 putative CheW interface [polypeptide binding]; other site 216596024067 Pfam match to entry PF00015.9 MCPsignal 216596024068 Pfam match to entry PF00672.10 HAMP 216596024069 2 probable transmembrane helices predicted at aa 15-37 and 424-446 216596024070 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 216596024071 Peptidase family M23; Region: Peptidase_M23; pfam01551 216596024072 1 probable transmembrane helix predicted at aa 32-54 216596024073 Pfam match to entry PF01551.6 Peptidase_M23 216596024074 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 216596024075 Clp amino terminal domain; Region: Clp_N; pfam02861 216596024076 Clp amino terminal domain; Region: Clp_N; pfam02861 216596024077 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216596024078 Walker A motif; other site 216596024079 ATP binding site [chemical binding]; other site 216596024080 Walker B motif; other site 216596024081 arginine finger; other site 216596024082 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216596024083 Walker A motif; other site 216596024084 ATP binding site [chemical binding]; other site 216596024085 Walker B motif; other site 216596024086 arginine finger; other site 216596024087 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 216596024088 Pfam match to entry PF00004.12 AAA 216596024089 Pfam match to entry PF02861.5 Clp_N 216596024090 Pfam match to entry PF02861.5 Clp_N 216596024091 Domain of unknown function (DUF4167); Region: DUF4167; pfam13763 216596024092 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 216596024093 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596024094 S-adenosylmethionine binding site [chemical binding]; other site 216596024095 peptide chain release factor 1; Validated; Region: prfA; PRK00591 216596024096 This domain is found in peptide chain release factors; Region: PCRF; smart00937 216596024097 RF-1 domain; Region: RF-1; pfam00472 216596024098 Pfam match to entry PF00472.8 RF-1 216596024099 Pfam match to entry PF03462.5 PCRF 216596024100 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 216596024101 GAF domain; Region: GAF; pfam01590 216596024102 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 216596024103 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 216596024104 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 216596024105 Pfam match to entry PF02896.6 PEP-utilizers_C 216596024106 Pfam match to entry PF00391.9 PEP-utilizers 216596024107 Pfam match to entry PF05524.1 PEP-utilisers_N 216596024108 Pfam match to entry PF01590.11 GAF 216596024109 aspartate kinase; Reviewed; Region: PRK06635 216596024110 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 216596024111 putative nucleotide binding site [chemical binding]; other site 216596024112 putative catalytic residues [active] 216596024113 putative Mg ion binding site [ion binding]; other site 216596024114 putative aspartate binding site [chemical binding]; other site 216596024115 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 216596024116 putative allosteric regulatory site; other site 216596024117 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 216596024118 Pfam match to entry PF01842.8 ACT 216596024119 Pfam match to entry PF01842.8 ACT 216596024120 Pfam match to entry PF00696.12 AA_kinase 216596024121 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 216596024122 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596024123 S-adenosylmethionine binding site [chemical binding]; other site 216596024124 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5319 216596024125 Pfam match to entry PF06676.1 DUF1178 216596024126 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 216596024127 nitrilase; Region: PLN02798 216596024128 putative active site [active] 216596024129 catalytic triad [active] 216596024130 dimer interface [polypeptide binding]; other site 216596024131 Pfam match to entry PF00795.10 CN_hydrolase 216596024132 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 216596024133 GSH binding site [chemical binding]; other site 216596024134 catalytic residues [active] 216596024135 Pfam match to entry PF00462.9 Glutaredoxin 216596024136 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 216596024137 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 216596024138 active site 216596024139 Pfam match to entry PF00156.11 Pribosyltran 216596024140 Methyltransferase domain; Region: Methyltransf_11; pfam08241 216596024141 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 216596024142 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 216596024143 Pfam match to entry PF04964.3 Flp_Fap 216596024144 1 probable transmembrane helix predicted at aa 46-68 216596024145 1 probable transmembrane helix predicted at aa 24-46 216596024146 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 216596024147 active site 216596024148 8-oxo-dGMP binding site [chemical binding]; other site 216596024149 nudix motif; other site 216596024150 metal binding site [ion binding]; metal-binding site 216596024151 Pfam match to entry PF00293.12 NUDIX 216596024152 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 216596024153 Pfam match to entry PF00583.9 Acetyltransf_1 216596024154 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 216596024155 heterotetramer interface [polypeptide binding]; other site 216596024156 active site pocket [active] 216596024157 cleavage site 216596024158 Pfam match to entry PF01960.6 ArgJ 216596024159 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 216596024160 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 216596024161 Pfam match to entry PF00639.8 Rotamase 216596024162 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 216596024163 DEAD/DEAH box helicase; Region: DEAD; pfam00270 216596024164 ATP binding site [chemical binding]; other site 216596024165 putative Mg++ binding site [ion binding]; other site 216596024166 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 216596024167 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 216596024168 nucleotide binding region [chemical binding]; other site 216596024169 SEC-C motif; Region: SEC-C; pfam02810 216596024170 Pfam match to entry PF07517.1 SecA_DEAD 216596024171 Pfam match to entry PF01043.8 SecA_PP_bind 216596024172 Pfam match to entry PF07516.1 SecA_SW 216596024173 Pfam match to entry PF02810.5 SEC-C 216596024174 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 216596024175 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 216596024176 Pfam match to entry PF01943.7 Polysacc_synt 216596024177 12 probable transmembrane helices predicted at aa 46-68, 83-105, 126-148, 152-174,187-209, 219-241, 254-276, 291-309, 341-363, 367-389,402-424 and 428-450 216596024178 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 216596024179 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 216596024180 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971 216596024181 active site 216596024182 acyl-activating enzyme (AAE) consensus motif; other site 216596024183 putative CoA binding site [chemical binding]; other site 216596024184 AMP binding site [chemical binding]; other site 216596024185 Pfam match to entry PF00501.11 AMP-binding 216596024186 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 216596024187 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 216596024188 active site 216596024189 catalytic tetrad [active] 216596024190 Pfam match to entry PF00248.9 Aldo_ket_red 216596024191 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216596024192 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216596024193 Pfam match to entry PF00440.8 TetR_N 216596024194 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596024195 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216596024196 putative substrate translocation pore; other site 216596024197 11 probable transmembrane helices predicted at aa 20-42, 60-82, 87-109, 113-135,144-166, 176-195, 240-262, 277-299, 320-342, 366-388 and 395-417 216596024198 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 216596024199 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 216596024200 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 216596024201 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 216596024202 ligand binding site [chemical binding]; other site 216596024203 flexible hinge region; other site 216596024204 12 probable transmembrane helices predicted at aa 5-25, 32-51, 55-77, 82-104,114-136, 149-171, 191-213, 234-268, 283-305, 312-334,349-368 and 375-397 216596024205 Pfam match to entry PF00999.9 Na_H_Exchanger 216596024206 Pfam match to entry PF00027.13 cNMP_binding 216596024207 Predicted membrane protein [Function unknown]; Region: COG1238 216596024208 5 probable transmembrane helices predicted at aa 20-42, 57-79, 100-122, 132-154 and 173-195 216596024209 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 216596024210 4 probable transmembrane helices predicted at aa 13-35, 50-70, 77-99 and 143-165 216596024211 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 216596024212 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 216596024213 active site 216596024214 Pfam match to entry PF01844.10 HNH 216596024215 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 216596024216 endonuclease III; Region: ENDO3c; smart00478 216596024217 minor groove reading motif; other site 216596024218 helix-hairpin-helix signature motif; other site 216596024219 substrate binding pocket [chemical binding]; other site 216596024220 active site 216596024221 Pfam match to entry PF00730.11 HhH-GPD 216596024222 Similar to Bacillus stearothermophilus gltx glutamyl-trna synthetase (ec 6.1.1.17) (glutamate--trna ligase) (glurs). UniProt:SYE_BACST (EMBL:BSGLTX) (489 aa), and to Agrobacterium tumefaciens (strain C58/ATCC 33970) gltx glutamyl-trna synthetase (agr_l_2475p). UniProt:Q8U9Y6_AGRT5 (EMBL:AE008324) (299 aa); similarity:fasta; with=UniProt:SYE_BACST (EMBL:BSGLTX); Bacillus stearothermophilus.; gltX; Glutamyl-tRNA synthetase (EC 6.1.1.17) (Glutamate--tRNA ligase) (GluRS).; length=489; id 28.137; 263 aa overlap; query 18-272; subject 9-256; similarity:fasta; with=UniProt:Q8U9Y6_AGRT5 (EMBL:AE008324); Agrobacterium tumefaciens (strain C58/ATCC 33970).; gltX; Glutamyl-tRNA Synthetase (AGR_L_2475p).; length=299; id 69.463; 298 aa overlap; query 1-298; subject 1-298 216596024223 Pfam match to entry PF00749.9 tRNA-synt_1c 216596024224 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 216596024225 Pfam match to entry PF03631.3 Ribonuclease_BN 216596024226 6 probable transmembrane helices predicted at aa 33-55, 93-115, 136-158, 178-200,213-235 and 250-272 216596024227 short chain dehydrogenase; Provisional; Region: PRK05993 216596024228 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 216596024229 NADP binding site [chemical binding]; other site 216596024230 active site 216596024231 steroid binding site; other site 216596024232 Pfam match to entry PF00106.11 adh_short 216596024233 Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588 216596024234 2 probable transmembrane helices predicted at aa 4-26 and 39-61 216596024235 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 216596024236 Pfam match to entry PF01923.6 Cob_adeno_trans 216596024237 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 216596024238 7 probable transmembrane helices predicted at aa 15-34, 47-66, 76-98, 111-130,135-154, 161-183 and 198-216 216596024239 Pfam match to entry PF01694.8 Rhomboid 216596024240 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 216596024241 Ligand binding site [chemical binding]; other site 216596024242 Electron transfer flavoprotein domain; Region: ETF; pfam01012 216596024243 Pfam match to entry PF01012.9 ETF_beta 216596024244 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 216596024245 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 216596024246 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 216596024247 Pfam match to entry PF00766.8 ETF_alpha 216596024248 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 216596024249 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 216596024250 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 216596024251 Pfam match to entry PF02737.5 3HCDH_N 216596024252 Pfam match to entry PF00725.10 3HCDH 216596024253 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 216596024254 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 216596024255 catalytic residues [active] 216596024256 Signal peptide predicted for RL4322 by SignalP 2.0 HMM (Signal peptide probabilty 0.709) with cleavage site probability 0.474 between residues 41 and 42 216596024257 1 probable transmembrane helix predicted at aa 19-41 216596024258 argininosuccinate lyase; Provisional; Region: PRK00855 216596024259 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 216596024260 active sites [active] 216596024261 tetramer interface [polypeptide binding]; other site 216596024262 Pfam match to entry PF00206.9 Lyase_1 216596024263 1 probable transmembrane helix predicted at aa 13-30 216596024264 diaminopimelate decarboxylase; Region: lysA; TIGR01048 216596024265 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 216596024266 active site 216596024267 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 216596024268 substrate binding site [chemical binding]; other site 216596024269 catalytic residues [active] 216596024270 dimer interface [polypeptide binding]; other site 216596024271 Pfam match to entry PF02784.5 Orn_Arg_deC_N 216596024272 Pfam match to entry PF00278.10 Orn_DAP_Arg_deC 216596024273 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 216596024274 3 probable transmembrane helices predicted at aa 31-53, 68-90 and 160-182 216596024275 Response regulator receiver domain; Region: Response_reg; pfam00072 216596024276 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596024277 active site 216596024278 phosphorylation site [posttranslational modification] 216596024279 intermolecular recognition site; other site 216596024280 dimerization interface [polypeptide binding]; other site 216596024281 Pfam match to entry PF00072.9 Response_reg 216596024282 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 216596024283 active site 216596024284 Pfam match to entry PF00156.11 Pribosyltran 216596024285 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 216596024286 1 probable transmembrane helix predicted at aa 97-119 216596024287 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 216596024288 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 216596024289 Walker A/P-loop; other site 216596024290 ATP binding site [chemical binding]; other site 216596024291 Q-loop/lid; other site 216596024292 ABC transporter signature motif; other site 216596024293 Walker B; other site 216596024294 D-loop; other site 216596024295 H-loop/switch region; other site 216596024296 Pfam match to entry PF00005.11 ABC_tran 216596024297 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 216596024298 4 probable transmembrane helices predicted at aa 41-63, 185-207, 244-266 and 286-308 216596024299 Uncharacterized conserved protein [Function unknown]; Region: COG1434 216596024300 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 216596024301 putative active site [active] 216596024302 1 probable transmembrane helix predicted at aa 31-53 216596024303 Pfam match to entry PF02698.5 DUF218 216596024304 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 216596024305 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 216596024306 putative acyl-acceptor binding pocket; other site 216596024307 1 probable transmembrane helix predicted at aa 13-35 216596024308 Pfam match to entry PF01553.9 Acyltransferase 216596024309 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 216596024310 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 216596024311 putative active site pocket [active] 216596024312 dimerization interface [polypeptide binding]; other site 216596024313 putative catalytic residue [active] 216596024314 Pfam match to entry PF04752.2 ChaC 216596024315 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4093 216596024316 Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898 216596024317 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216596024318 Coenzyme A binding pocket [chemical binding]; other site 216596024319 Pfam match to entry PF00583.9 Acetyltransf_1 216596024320 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 216596024321 prephenate dehydrogenase; Validated; Region: PRK08507 216596024322 Pfam match to entry PF02153.6 PDH 216596024323 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 216596024324 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216596024325 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596024326 homodimer interface [polypeptide binding]; other site 216596024327 catalytic residue [active] 216596024328 Pfam match to entry PF00155.8 Aminotran_1_2 216596024329 Methyltransferase domain; Region: Methyltransf_23; pfam13489 216596024330 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596024331 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 216596024332 Pfam match to entry PF00753.12 Lactamase_B 216596024333 Uncharacterized conserved protein [Function unknown]; Region: COG3542 216596024334 Pfam match to entry PF06172.1 DUF985 216596024335 aromatic amino acid exporter; Provisional; Region: PRK11689 216596024336 EamA-like transporter family; Region: EamA; pfam00892 216596024337 Pfam match to entry PF00892.8 DUF6 216596024338 10 probable transmembrane helices predicted at aa 7-26, 31-53, 66-85, 89-111,118-140, 144-166, 173-195, 208-230, 237-259 and 263-280 216596024339 Pfam match to entry PF00892.8 DUF6 216596024340 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 216596024341 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 216596024342 6 probable transmembrane helices predicted at aa 7-29, 33-55, 67-86, 91-113,126-148 and 176-198 216596024343 Pfam match to entry PF02592.4 DUF165 216596024344 conserved hypothetical protein, pseudogene; similarity:fasta; with=UniProt:YQAC_BACSU (EMBL:BSJH642); Bacillus subtilis.; yqaC; Hypothetical protein yqaC precursor.; length=178; id 42.775; 173 aa overlap; query 2-174; subject 4-172 216596024345 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 216596024346 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 216596024347 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 216596024348 cobaltochelatase, CobT subunit; Region: CobT; TIGR01651 216596024349 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 216596024350 metal ion-dependent adhesion site (MIDAS); other site 216596024351 Pfam match to entry PF06213.2 CobT 216596024352 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 216596024353 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 216596024354 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 216596024355 Pfam match to entry PF06383.1 P_denitri_CobS 216596024356 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 216596024357 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 216596024358 HSP70 interaction site [polypeptide binding]; other site 216596024359 Pfam match to entry PF00226.13 DnaJ 216596024360 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 216596024361 Domain of unknown function DUF21; Region: DUF21; pfam01595 216596024362 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 216596024363 Transporter associated domain; Region: CorC_HlyC; smart01091 216596024364 Pfam match to entry PF03471.5 CorC_HlyC 216596024365 Pfam match to entry PF00571.13 CBS 216596024366 Pfam match to entry PF00571.13 CBS 216596024367 Pfam match to entry PF01595.7 DUF21 216596024368 4 probable transmembrane helices predicted at aa 10-32, 70-92, 97-119 and 131-153 216596024369 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 216596024370 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 216596024371 active site 216596024372 dimer interface [polypeptide binding]; other site 216596024373 metal binding site [ion binding]; metal-binding site 216596024374 Pfam match to entry PF01761.6 DHQ_synthase 216596024375 shikimate kinase; Provisional; Region: PRK13946 216596024376 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 216596024377 ADP binding site [chemical binding]; other site 216596024378 magnesium binding site [ion binding]; other site 216596024379 putative shikimate binding site; other site 216596024380 Pfam match to entry PF01202.7 SKI 216596024381 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 216596024382 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 216596024383 active site 216596024384 DNA binding site [nucleotide binding] 216596024385 Int/Topo IB signature motif; other site 216596024386 Pfam match to entry PF02899.5 Phage_integr_N 216596024387 Pfam match to entry PF00589.8 Phage_integrase 216596024388 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 216596024389 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 216596024390 Pfam match to entry PF03255.3 ACCA 216596024391 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 216596024392 Pfam match to entry PF06104.1 DUF949 216596024393 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 216596024394 CPxP motif; other site 216596024395 Pfam match to entry PF01206.7 SirA 216596024396 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 216596024397 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 216596024398 Pfam match to entry PF03480.3 SBP_bac_7 216596024399 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 216596024400 4 probable transmembrane helices predicted at aa 17-39, 54-71, 100-122 and 132-151 216596024401 Pfam match to entry PF04290.2 DctQ 216596024402 DctM-like transporters; Region: DctM; pfam06808 216596024403 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 216596024404 13 probable transmembrane helices predicted at aa 5-27, 42-64, 71-90, 100-122,135-157, 172-194, 207-229, 234-256, 277-299, 314-331,336-353, 363-385 and 397-419 216596024405 Pfam match to entry PF06808.1 DctM 216596024406 Pfam match to entry PF00597.8 DedA 216596024407 Transcriptional regulators [Transcription]; Region: FadR; COG2186 216596024408 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596024409 DNA-binding site [nucleotide binding]; DNA binding site 216596024410 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 216596024411 Pfam match to entry PF00392.9 GntR 216596024412 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 216596024413 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 216596024414 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 216596024415 Pfam match to entry PF02492.6 cobW 216596024416 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 216596024417 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 216596024418 Pfam match to entry PF00768.8 Peptidase_S11 216596024419 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 216596024420 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 216596024421 metal binding site [ion binding]; metal-binding site 216596024422 putative dimer interface [polypeptide binding]; other site 216596024423 Pfam match to entry PF01546.12 Peptidase_M20 216596024424 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 216596024425 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 216596024426 Pfam match to entry PF06751.1 EutB 216596024427 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 216596024428 Pfam match to entry PF05985.1 EutC 216596024429 ethanolamine permease; Region: 2A0305; TIGR00908 216596024430 13 probable transmembrane helices predicted at aa 15-37, 42-64, 79-98, 100-122,127-149, 151-173, 188-210, 231-253, 279-301, 329-351,361-383, 396-418 and 422-444 216596024431 Pfam match to entry PF00324.10 AA_permease 216596024432 Protein of unknown function (DUF2937); Region: DUF2937; pfam11157 216596024433 1 probable transmembrane helix predicted at aa 137-159 216596024434 BON domain; Region: BON; pfam04972 216596024435 Pfam match to entry PF04972.3 BON 216596024436 1 probable transmembrane helix predicted at aa 21-38 216596024437 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 216596024438 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 216596024439 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 216596024440 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 216596024441 Pfam match to entry PF02670.4 DXP_reductoisom 216596024442 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 216596024443 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 216596024444 Walker A/P-loop; other site 216596024445 ATP binding site [chemical binding]; other site 216596024446 Q-loop/lid; other site 216596024447 ABC transporter signature motif; other site 216596024448 Walker B; other site 216596024449 D-loop; other site 216596024450 H-loop/switch region; other site 216596024451 TOBE domain; Region: TOBE_2; pfam08402 216596024452 Pfam match to entry PF03459.4 TOBE 216596024453 Pfam match to entry PF00005.11 ABC_tran 216596024454 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 216596024455 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 216596024456 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216596024457 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596024458 dimer interface [polypeptide binding]; other site 216596024459 conserved gate region; other site 216596024460 putative PBP binding loops; other site 216596024461 ABC-ATPase subunit interface; other site 216596024462 Pfam match to entry PF00528.10 BPD_transp_1 216596024463 6 probable transmembrane helices predicted at aa 20-42, 83-105, 117-139, 149-171,192-214 and 254-273 216596024464 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 216596024465 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596024466 putative PBP binding loops; other site 216596024467 ABC-ATPase subunit interface; other site 216596024468 Pfam match to entry PF00528.10 BPD_transp_1 216596024469 6 probable transmembrane helices predicted at aa 24-46, 84-106, 119-141, 168-190,226-248 and 277-299 216596024470 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 216596024471 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 216596024472 Pfam match to entry PF01547.11 SBP_bac_1 216596024473 1 probable transmembrane helix predicted at aa 185-207 216596024474 Signal peptide predicted for RL4377 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.921 between residues 30 and 31 216596024475 Transcriptional regulators [Transcription]; Region: PurR; COG1609 216596024476 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216596024477 DNA binding site [nucleotide binding] 216596024478 domain linker motif; other site 216596024479 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 216596024480 dimerization interface [polypeptide binding]; other site 216596024481 ligand binding site [chemical binding]; other site 216596024482 Pfam match to entry PF00532.8 Peripla_BP_1 216596024483 Pfam match to entry PF00356.8 LacI 216596024484 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 216596024485 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 216596024486 substrate-cofactor binding pocket; other site 216596024487 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596024488 catalytic residue [active] 216596024489 Pfam match to entry PF00155.8 Aminotran_1_2 216596024490 Pfam match to entry PF02490.6 ALA_synthase 216596024491 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 216596024492 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 216596024493 Surface antigen; Region: Bac_surface_Ag; pfam01103 216596024494 1 probable transmembrane helix predicted at aa 21-40 216596024495 Pfam match to entry PF07244.1 Surf_Ag_VNR 216596024496 Pfam match to entry PF01103.10 Bac_surface_Ag 216596024497 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 216596024498 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 216596024499 Family of unknown function (DUF490); Region: DUF490; pfam04357 216596024500 1 probable transmembrane helix predicted at aa 48-70 216596024501 Pfam match to entry PF05594.2 Fil_haemagg 216596024502 Pfam match to entry PF05594.2 Fil_haemagg 216596024503 Pfam match to entry PF05594.2 Fil_haemagg 216596024504 Pfam match to entry PF05594.2 Fil_haemagg 216596024505 Pfam match to entry PF05594.2 Fil_haemagg 216596024506 Pfam match to entry PF04357.2 DUF490 216596024507 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 216596024508 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 216596024509 AsnC family; Region: AsnC_trans_reg; pfam01037 216596024510 Pfam match to entry PF01037.8 AsnC_trans_reg 216596024511 Arginase family; Region: Arginase; cd09989 216596024512 active site 216596024513 Mn binding site [ion binding]; other site 216596024514 oligomer interface [polypeptide binding]; other site 216596024515 Pfam match to entry PF00491.9 Arginase 216596024516 ornithine--oxo-acid transaminase; Reviewed; Region: rocD; PRK00854 216596024517 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 216596024518 inhibitor-cofactor binding pocket; inhibition site 216596024519 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596024520 catalytic residue [active] 216596024521 Pfam match to entry PF00202.8 Aminotran_3 216596024522 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 216596024523 putative CheA interaction surface; other site 216596024524 Pfam match to entry PF01584.7 CheW 216596024525 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216596024526 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 216596024527 putative active site [active] 216596024528 heme pocket [chemical binding]; other site 216596024529 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216596024530 putative active site [active] 216596024531 heme pocket [chemical binding]; other site 216596024532 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 216596024533 dimer interface [polypeptide binding]; other site 216596024534 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 216596024535 putative CheW interface [polypeptide binding]; other site 216596024536 Pfam match to entry PF00785.11 PAC 216596024537 Pfam match to entry PF00785.11 PAC 216596024538 Pfam match to entry PF00015.9 MCPsignal 216596024539 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216596024540 13 probable transmembrane helices predicted at aa 32-54, 91-113, 120-142, 147-169,182-204, 214-236, 276-298, 328-350, 362-384, 389-411,423-445, 460-482 and 527-549 216596024541 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 216596024542 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 216596024543 Pfam match to entry PF02634.4 FdhD-NarQ 216596024544 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 216596024545 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 216596024546 catalytic loop [active] 216596024547 iron binding site [ion binding]; other site 216596024548 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 216596024549 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 216596024550 [4Fe-4S] binding site [ion binding]; other site 216596024551 molybdopterin cofactor binding site; other site 216596024552 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 216596024553 molybdopterin cofactor binding site; other site 216596024554 Pfam match to entry PF01568.7 Molydop_binding 216596024555 Pfam match to entry PF00384.9 Molybdopterin 216596024556 Pfam match to entry PF04879.3 Molybdop_Fe4S4 216596024557 Pfam match to entry PF00037.11 Fer4 216596024558 Pfam match to entry PF00037.11 Fer4 216596024559 Pfam match to entry PF00111.12 Fer2 216596024560 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 216596024561 putative dimer interface [polypeptide binding]; other site 216596024562 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 216596024563 SLBB domain; Region: SLBB; pfam10531 216596024564 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 216596024565 Pfam match to entry PF01512.6 Complex1_51K 216596024566 formate dehydrogenase subunit gamma; Validated; Region: PRK05988 216596024567 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 216596024568 putative dimer interface [polypeptide binding]; other site 216596024569 [2Fe-2S] cluster binding site [ion binding]; other site 216596024570 Pfam match to entry PF01257.7 Complex1_24kDa 216596024571 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596024572 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596024573 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 216596024574 dimerization interface [polypeptide binding]; other site 216596024575 Pfam match to entry PF03466.5 LysR_substrate 216596024576 Pfam match to entry PF00126.10 HTH_1 216596024577 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216596024578 dimerization interface [polypeptide binding]; other site 216596024579 putative DNA binding site [nucleotide binding]; other site 216596024580 putative Zn2+ binding site [ion binding]; other site 216596024581 1 probable transmembrane helix predicted at aa 72-94 216596024582 Pfam match to entry PF01022.8 HTH_5 216596024583 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 216596024584 classical (c) SDRs; Region: SDR_c; cd05233 216596024585 NAD(P) binding site [chemical binding]; other site 216596024586 active site 216596024587 Pfam match to entry PF00106.11 adh_short 216596024588 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 216596024589 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 216596024590 DNA binding residues [nucleotide binding] 216596024591 dimer interface [polypeptide binding]; other site 216596024592 [2Fe-2S] cluster binding site [ion binding]; other site 216596024593 Pfam match to entry PF00376.9 MerR 216596024594 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 216596024595 Predicted flavoprotein [General function prediction only]; Region: COG0431 216596024596 Pfam match to entry PF03358.3 FMN_red 216596024597 YKOF-related Family; Region: Ykof; pfam07615 216596024598 YKOF-related Family; Region: Ykof; pfam07615 216596024599 Pfam match to entry PF07615.1 Ykof 216596024600 Pfam match to entry PF07615.1 Ykof 216596024601 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 216596024602 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596024603 putative PBP binding loops; other site 216596024604 ABC-ATPase subunit interface; other site 216596024605 6 probable transmembrane helices predicted at aa 17-39, 73-95, 104-126, 130-152,185-207 and 231-253 216596024606 Pfam match to entry PF00528.10 BPD_transp_1 216596024607 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 216596024608 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 216596024609 Walker A/P-loop; other site 216596024610 ATP binding site [chemical binding]; other site 216596024611 Q-loop/lid; other site 216596024612 ABC transporter signature motif; other site 216596024613 Walker B; other site 216596024614 D-loop; other site 216596024615 H-loop/switch region; other site 216596024616 Pfam match to entry PF00005.11 ABC_tran 216596024617 NMT1/THI5 like; Region: NMT1; pfam09084 216596024618 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 216596024619 substrate binding pocket [chemical binding]; other site 216596024620 membrane-bound complex binding site; other site 216596024621 hinge residues; other site 216596024622 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 216596024623 Pfam match to entry PF01757.9 Acyl_transf_3 216596024624 10 probable transmembrane helices predicted at aa 12-30, 50-72, 93-115, 154-173,180-202, 222-244, 256-273, 283-305, 318-340 and 360-382 216596024625 Bacterial sugar transferase; Region: Bac_transf; pfam02397 216596024626 Pfam match to entry PF02397.6 Bac_transf 216596024627 1 probable transmembrane helix predicted at aa 53-75 216596024628 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 216596024629 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 216596024630 gamma subunit interface [polypeptide binding]; other site 216596024631 epsilon subunit interface [polypeptide binding]; other site 216596024632 LBP interface [polypeptide binding]; other site 216596024633 Pfam match to entry PF02823.5 ATP-synt_DE_N 216596024634 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 216596024635 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 216596024636 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 216596024637 alpha subunit interaction interface [polypeptide binding]; other site 216596024638 Walker A motif; other site 216596024639 ATP binding site [chemical binding]; other site 216596024640 Walker B motif; other site 216596024641 inhibitor binding site; inhibition site 216596024642 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 216596024643 Pfam match to entry PF00306.11 ATP-synt_ab_C 216596024644 Pfam match to entry PF00006.9 ATP-synt_ab 216596024645 Pfam match to entry PF02874.7 ATP-synt_ab_N 216596024646 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 216596024647 core domain interface [polypeptide binding]; other site 216596024648 delta subunit interface [polypeptide binding]; other site 216596024649 epsilon subunit interface [polypeptide binding]; other site 216596024650 Pfam match to entry PF00231.8 ATP-synt 216596024651 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 216596024652 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 216596024653 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 216596024654 beta subunit interaction interface [polypeptide binding]; other site 216596024655 Walker A motif; other site 216596024656 ATP binding site [chemical binding]; other site 216596024657 Walker B motif; other site 216596024658 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 216596024659 Pfam match to entry PF00306.11 ATP-synt_ab_C 216596024660 Pfam match to entry PF00006.9 ATP-synt_ab 216596024661 Pfam match to entry PF02874.7 ATP-synt_ab_N 216596024662 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 216596024663 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 216596024664 Pfam match to entry PF00213.8 OSCP 216596024665 3 probable transmembrane helices predicted at aa 20-42, 81-103 and 110-132 216596024666 primosome assembly protein PriA; Validated; Region: PRK05580 216596024667 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 216596024668 ATP binding site [chemical binding]; other site 216596024669 putative Mg++ binding site [ion binding]; other site 216596024670 helicase superfamily c-terminal domain; Region: HELICc; smart00490 216596024671 Pfam match to entry PF00271.13 Helicase_C 216596024672 Pfam match to entry PF00270.12 DEAD 216596024673 Pfam match to entry PF04851.3 ResIII 216596024674 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 216596024675 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596024676 Walker A/P-loop; other site 216596024677 ATP binding site [chemical binding]; other site 216596024678 Q-loop/lid; other site 216596024679 ABC transporter signature motif; other site 216596024680 Walker B; other site 216596024681 D-loop; other site 216596024682 H-loop/switch region; other site 216596024683 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216596024684 Pfam match to entry PF00005.11 ABC_tran 216596024685 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 216596024686 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596024687 Walker A/P-loop; other site 216596024688 ATP binding site [chemical binding]; other site 216596024689 Q-loop/lid; other site 216596024690 ABC transporter signature motif; other site 216596024691 Walker B; other site 216596024692 D-loop; other site 216596024693 H-loop/switch region; other site 216596024694 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 216596024695 Pfam match to entry PF00005.11 ABC_tran 216596024696 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 216596024697 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596024698 dimer interface [polypeptide binding]; other site 216596024699 conserved gate region; other site 216596024700 putative PBP binding loops; other site 216596024701 ABC-ATPase subunit interface; other site 216596024702 Pfam match to entry PF00528.10 BPD_transp_1 216596024703 5 probable transmembrane helices predicted at aa 15-37, 79-101, 111-133, 190-212 and 246-268 216596024704 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 216596024705 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596024706 dimer interface [polypeptide binding]; other site 216596024707 conserved gate region; other site 216596024708 putative PBP binding loops; other site 216596024709 ABC-ATPase subunit interface; other site 216596024710 Pfam match to entry PF00528.10 BPD_transp_1 216596024711 6 probable transmembrane helices predicted at aa 13-35, 112-134, 155-177, 197-219,260-282 and 302-324 216596024712 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 216596024713 substrate binding site [chemical binding]; other site 216596024714 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 216596024715 Pfam match to entry PF00496.8 SBP_bac_5 216596024716 1 probable transmembrane helix predicted at aa 41-63 216596024717 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 216596024718 Pfam match to entry PF01229.7 Glyco_hydro_39 216596024719 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596024720 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 216596024721 DNA-binding site [nucleotide binding]; DNA binding site 216596024722 FCD domain; Region: FCD; pfam07729 216596024723 Pfam match to entry PF00392.9 GntR 216596024724 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 216596024725 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 216596024726 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 216596024727 Pfam match to entry PF02894.4 GFO_IDH_MocA_C 216596024728 Pfam match to entry PF01408.8 GFO_IDH_MocA 216596024729 dihydroxy-acid dehydratase; Validated; Region: PRK06131 216596024730 Pfam match to entry PF00920.9 ILVD_EDD 216596024731 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 216596024732 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 216596024733 active site 216596024734 Pfam match to entry PF04909.2 Amidohydro_2 216596024735 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 216596024736 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 216596024737 inhibitor site; inhibition site 216596024738 active site 216596024739 dimer interface [polypeptide binding]; other site 216596024740 catalytic residue [active] 216596024741 Pfam match to entry PF00701.10 DHDPS 216596024742 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 216596024743 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216596024744 Coenzyme A binding pocket [chemical binding]; other site 216596024745 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 216596024746 Pfam match to entry PF00583.9 Acetyltransf_1 216596024747 Putative hemolysin [General function prediction only]; Region: COG3176 216596024748 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 216596024749 Pfam match to entry PF01553.9 Acyltransferase 216596024750 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 216596024751 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 216596024752 active site 216596024753 DNA binding site [nucleotide binding] 216596024754 Int/Topo IB signature motif; other site 216596024755 Pfam match to entry PF02899.5 Phage_integr_N 216596024756 Pfam match to entry PF00589.8 Phage_integrase 216596024757 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 216596024758 1 probable transmembrane helix predicted at aa 5-27 216596024759 Pfam match to entry PF07446.1 GumN 216596024760 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 216596024761 Pfam match to entry PF01292.9 Ni_hydr_CYTB 216596024762 3 probable transmembrane helices predicted at aa 15-37, 98-120 and 135-154 216596024763 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 216596024764 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 216596024765 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 216596024766 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 216596024767 Pfam match to entry PF02852.6 Pyr_redox_dim 216596024768 Pfam match to entry PF00070.12 Pyr_redox 216596024769 classical (c) SDRs; Region: SDR_c; cd05233 216596024770 NAD(P) binding site [chemical binding]; other site 216596024771 active site 216596024772 Pfam match to entry PF00106.11 adh_short 216596024773 1 probable transmembrane helix predicted at aa 12-34 216596024774 Protein of unknown function (DUF4241); Region: DUF4241; pfam14025 216596024775 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 216596024776 E3 interaction surface; other site 216596024777 lipoyl attachment site [posttranslational modification]; other site 216596024778 e3 binding domain; Region: E3_binding; pfam02817 216596024779 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 216596024780 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 216596024781 Pfam match to entry PF00198.10 2-oxoacid_dh 216596024782 Pfam match to entry PF02817.4 E3_binding 216596024783 Pfam match to entry PF00364.9 Biotin_lipoyl 216596024784 YCII-related domain; Region: YCII; cl00999 216596024785 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 216596024786 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 216596024787 TPP-binding site [chemical binding]; other site 216596024788 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 216596024789 Pfam match to entry PF02779.8 Transket_pyr 216596024790 Pfam match to entry PF00676.8 E1_dh 216596024791 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 216596024792 CoA binding domain; Region: CoA_binding; smart00881 216596024793 CoA-ligase; Region: Ligase_CoA; pfam00549 216596024794 Pfam match to entry PF00549.9 Ligase_CoA 216596024795 Pfam match to entry PF02629.7 CoA_binding 216596024796 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 216596024797 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 216596024798 CoA-ligase; Region: Ligase_CoA; pfam00549 216596024799 Pfam match to entry PF00549.9 Ligase_CoA 216596024800 Pfam match to entry PF02222.7 ATP-grasp 216596024801 malate dehydrogenase; Reviewed; Region: PRK06223 216596024802 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 216596024803 NAD(P) binding site [chemical binding]; other site 216596024804 dimer interface [polypeptide binding]; other site 216596024805 tetramer (dimer of dimers) interface [polypeptide binding]; other site 216596024806 substrate binding site [chemical binding]; other site 216596024807 Pfam match to entry PF02866.4 Ldh_1_C 216596024808 Pfam match to entry PF00056.9 Ldh_1_N 216596024809 1 probable transmembrane helix predicted at aa 21-38 216596024810 Predicted ATPase [General function prediction only]; Region: COG1485 216596024811 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216596024812 Walker B; other site 216596024813 D-loop; other site 216596024814 H-loop/switch region; other site 216596024815 Pfam match to entry PF03969.4 AFG1_ATPase 216596024816 Protease inhibitor Inh; Region: Inh; pfam02974 216596024817 Pfam match to entry PF06604.1 OMP_19 216596024818 Signal peptide predicted for RL4441 by SignalP 2.0 HMM (Signal peptide probabilty 0.990) with cleavage site probability 0.633 between residues 33 and 34 216596024819 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 216596024820 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 216596024821 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 216596024822 L-aspartate oxidase; Provisional; Region: PRK06175 216596024823 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 216596024824 Pfam match to entry PF02910.6 Succ_DH_flav_C 216596024825 Pfam match to entry PF00890.10 FAD_binding_2 216596024826 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 216596024827 putative SdhC subunit interface [polypeptide binding]; other site 216596024828 putative proximal heme binding site [chemical binding]; other site 216596024829 putative Iron-sulfur protein interface [polypeptide binding]; other site 216596024830 putative proximal quinone binding site; other site 216596024831 3 probable transmembrane helices predicted at aa 28-50, 55-77 and 98-120 216596024832 Pfam match to entry PF01127.9 Sdh_cyt 216596024833 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 216596024834 Iron-sulfur protein interface; other site 216596024835 proximal quinone binding site [chemical binding]; other site 216596024836 SdhD (CybS) interface [polypeptide binding]; other site 216596024837 proximal heme binding site [chemical binding]; other site 216596024838 3 probable transmembrane helices predicted at aa 58-80, 90-112 and 138-160 216596024839 Pfam match to entry PF01127.9 Sdh_cyt 216596024840 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 216596024841 homotrimer interaction site [polypeptide binding]; other site 216596024842 putative active site [active] 216596024843 Pfam match to entry PF01042.8 Ribonuc_L-PSP 216596024844 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596024845 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596024846 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216596024847 dimerization interface [polypeptide binding]; other site 216596024848 Pfam match to entry PF03466.5 LysR_substrate 216596024849 Pfam match to entry PF00126.10 HTH_1 216596024850 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 216596024851 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216596024852 Walker A/P-loop; other site 216596024853 ATP binding site [chemical binding]; other site 216596024854 Q-loop/lid; other site 216596024855 ABC transporter signature motif; other site 216596024856 Walker B; other site 216596024857 D-loop; other site 216596024858 H-loop/switch region; other site 216596024859 TOBE domain; Region: TOBE_2; pfam08402 216596024860 Pfam match to entry PF03459.4 TOBE 216596024861 Pfam match to entry PF00005.11 ABC_tran 216596024862 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 216596024863 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596024864 dimer interface [polypeptide binding]; other site 216596024865 conserved gate region; other site 216596024866 putative PBP binding loops; other site 216596024867 ABC-ATPase subunit interface; other site 216596024868 Pfam match to entry PF00528.10 BPD_transp_1 216596024869 6 probable transmembrane helices predicted at aa 15-37, 78-100, 110-132, 145-167,187-209 and 240-262 216596024870 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596024871 dimer interface [polypeptide binding]; other site 216596024872 conserved gate region; other site 216596024873 putative PBP binding loops; other site 216596024874 ABC-ATPase subunit interface; other site 216596024875 Pfam match to entry PF00528.10 BPD_transp_1 216596024876 6 probable transmembrane helices predicted at aa 21-43, 83-105, 117-139, 161-183,219-241 and 265-287 216596024877 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 216596024878 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 216596024879 agmatinase; Region: agmatinase; TIGR01230 216596024880 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 216596024881 oligomer interface [polypeptide binding]; other site 216596024882 putative active site [active] 216596024883 Mn binding site [ion binding]; other site 216596024884 Pfam match to entry PF00491.9 Arginase 216596024885 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 216596024886 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 216596024887 substrate binding pocket [chemical binding]; other site 216596024888 membrane-bound complex binding site; other site 216596024889 hinge residues; other site 216596024890 Pfam match to entry PF00497.8 SBP_bac_3 216596024891 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596024892 dimer interface [polypeptide binding]; other site 216596024893 conserved gate region; other site 216596024894 putative PBP binding loops; other site 216596024895 ABC-ATPase subunit interface; other site 216596024896 Pfam match to entry PF00528.10 BPD_transp_1 216596024897 5 probable transmembrane helices predicted at aa 20-42, 63-85, 90-112, 133-155 and 188-210 216596024898 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 216596024899 Pfam match to entry PF00528.10 BPD_transp_1 216596024900 4 probable transmembrane helices predicted at aa 21-43, 58-80, 148-166 and 186-208 216596024901 ornithine cyclodeaminase; Validated; Region: PRK06141 216596024902 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 216596024903 Pfam match to entry PF02423.5 OCD_Mu_crystall 216596024904 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596024905 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596024906 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596024907 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596024908 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 216596024909 dimerization interface [polypeptide binding]; other site 216596024910 Pfam match to entry PF00126.10 HTH_1 216596024911 Pfam match to entry PF00126.10 HTH_1 216596024912 Pfam match to entry PF03466.5 LysR_substrate 216596024913 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 216596024914 Pfam match to entry PF01977.6 UbiD 216596024915 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 216596024916 Flavoprotein; Region: Flavoprotein; pfam02441 216596024917 Pfam match to entry PF02441.6 Flavoprotein 216596024918 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 216596024919 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 216596024920 1 probable transmembrane helix predicted at aa 48-70 216596024921 Pfam match to entry PF00496.8 SBP_bac_5 216596024922 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 216596024923 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 216596024924 tetramer interface [polypeptide binding]; other site 216596024925 active site 216596024926 Mg2+/Mn2+ binding site [ion binding]; other site 216596024927 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 216596024928 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596024929 dimer interface [polypeptide binding]; other site 216596024930 conserved gate region; other site 216596024931 putative PBP binding loops; other site 216596024932 ABC-ATPase subunit interface; other site 216596024933 6 probable transmembrane helices predicted at aa 57-79, 148-170, 191-213, 228-250,301-323 and 338-360 216596024934 Pfam match to entry PF00528.10 BPD_transp_1 216596024935 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 216596024936 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596024937 dimer interface [polypeptide binding]; other site 216596024938 conserved gate region; other site 216596024939 putative PBP binding loops; other site 216596024940 ABC-ATPase subunit interface; other site 216596024941 5 probable transmembrane helices predicted at aa 43-65, 109-131, 155-177, 217-239 and 271-293 216596024942 Pfam match to entry PF00528.10 BPD_transp_1 216596024943 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 216596024944 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596024945 Walker A/P-loop; other site 216596024946 ATP binding site [chemical binding]; other site 216596024947 Q-loop/lid; other site 216596024948 ABC transporter signature motif; other site 216596024949 Walker B; other site 216596024950 D-loop; other site 216596024951 H-loop/switch region; other site 216596024952 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216596024953 Pfam match to entry PF00005.11 ABC_tran 216596024954 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 216596024955 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596024956 Walker A/P-loop; other site 216596024957 ATP binding site [chemical binding]; other site 216596024958 Q-loop/lid; other site 216596024959 ABC transporter signature motif; other site 216596024960 Walker B; other site 216596024961 D-loop; other site 216596024962 H-loop/switch region; other site 216596024963 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216596024964 Pfam match to entry PF00005.11 ABC_tran 216596024965 Protein of unknown function (DUF2390); Region: DUF2390; pfam09523 216596024966 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 216596024967 active sites [active] 216596024968 tetramer interface [polypeptide binding]; other site 216596024969 Pfam match to entry PF00221.7 PAL 216596024970 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 216596024971 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216596024972 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596024973 homodimer interface [polypeptide binding]; other site 216596024974 catalytic residue [active] 216596024975 Pfam match to entry PF00155.8 Aminotran_1_2 216596024976 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 216596024977 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 216596024978 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 216596024979 active site 216596024980 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 216596024981 Pfam match to entry PF01979.7 Amidohydro_1 216596024982 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 216596024983 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 216596024984 Pfam match to entry PF03480.3 SBP_bac_7 216596024985 component of transporter, pseudogene; Codons 25 to 161 are similar to codons 40 to 180 of Bradyrhizobium japonicum blr2171 protein. UniProt:Q89T79_BRAJA (EMBL:BA000040) (630 aa); similarity:fasta; with=UniProt:Q89T79_BRAJA (EMBL:BA000040); Bradyrhizobium japonicum.; Blr2171 protein.; length=630; id 30.769; 143 aa overlap; query 25-160; subject 38-178 216596024986 4 probable transmembrane helices predicted at aa 21-43, 58-80, 100-122 and 137-159 216596024987 DctM-like transporters; Region: DctM; pfam06808 216596024988 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 216596024989 11 probable transmembrane helices predicted at aa 7-29, 44-66, 87-109, 141-163,170-192, 215-237, 242-264, 274-296, 309-331, 362-384 and 397-416 216596024990 Pfam match to entry PF06808.1 DctM 216596024991 Pfam match to entry PF00597.8 DedA 216596024992 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 216596024993 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 216596024994 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216596024995 catalytic residue [active] 216596024996 Pfam match to entry PF00202.8 Aminotran_3 216596024997 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596024998 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596024999 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216596025000 dimerization interface [polypeptide binding]; other site 216596025001 Pfam match to entry PF03466.5 LysR_substrate 216596025002 Pfam match to entry PF00126.10 HTH_1 216596025003 transposase, pseudogene; Similar to codons 60 to 111 of Rhizobium loti (Mesorhizobium loti) transposase. UniProt:Q98AE9_RHILO (EMBL:BA000012) (404 aa); similarity:fasta; with=UniProt:Q98AE9_RHILO (EMBL:BA000012); Rhizobium loti (Mesorhizobium loti).; Transposase.; length=404; id 70.000; 50 aa overlap; query 1-49; subject 61-110 216596025004 Transcriptional regulators [Transcription]; Region: FadR; COG2186 216596025005 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596025006 DNA-binding site [nucleotide binding]; DNA binding site 216596025007 FCD domain; Region: FCD; pfam07729 216596025008 Pfam match to entry PF00392.9 GntR 216596025009 Transcriptional regulators [Transcription]; Region: FadR; COG2186 216596025010 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 216596025011 DNA-binding site [nucleotide binding]; DNA binding site 216596025012 FCD domain; Region: FCD; pfam07729 216596025013 Pfam match to entry PF00392.9 GntR 216596025014 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 216596025015 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 216596025016 substrate binding pocket [chemical binding]; other site 216596025017 membrane-bound complex binding site; other site 216596025018 hinge residues; other site 216596025019 Pfam match to entry PF00497.8 SBP_bac_3 216596025020 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 216596025021 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596025022 dimer interface [polypeptide binding]; other site 216596025023 conserved gate region; other site 216596025024 putative PBP binding loops; other site 216596025025 ABC-ATPase subunit interface; other site 216596025026 Pfam match to entry PF00528.10 BPD_transp_1 216596025027 4 probable transmembrane helices predicted at aa 20-42, 62-84, 88-107 and 186-208 216596025028 N-acetylneuraminate lyase; Provisional; Region: PRK04147 216596025029 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 216596025030 inhibitor site; inhibition site 216596025031 active site 216596025032 dimer interface [polypeptide binding]; other site 216596025033 catalytic residue [active] 216596025034 Pfam match to entry PF00701.10 DHDPS 216596025035 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 216596025036 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 216596025037 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 216596025038 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 216596025039 hydroxyglutarate oxidase; Provisional; Region: PRK11728 216596025040 Pfam match to entry PF00070.12 Pyr_redox 216596025041 Pfam match to entry PF01494.7 FAD_binding_3 216596025042 Pfam match to entry PF04324.3 Fer2_BFD 216596025043 Pfam match to entry PF01266.8 DAO 216596025044 Pfam match to entry PF01494.7 FAD_binding_3 216596025045 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 216596025046 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 216596025047 Walker A/P-loop; other site 216596025048 ATP binding site [chemical binding]; other site 216596025049 Q-loop/lid; other site 216596025050 ABC transporter signature motif; other site 216596025051 Walker B; other site 216596025052 D-loop; other site 216596025053 H-loop/switch region; other site 216596025054 Pfam match to entry PF00005.11 ABC_tran 216596025055 phenylhydantoinase; Validated; Region: PRK08323 216596025056 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 216596025057 tetramer interface [polypeptide binding]; other site 216596025058 active site 216596025059 Pfam match to entry PF01979.7 Amidohydro_1 216596025060 Protein of unknown function (DUF3830); Region: DUF3830; pfam12903 216596025061 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 216596025062 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 216596025063 Pfam match to entry PF00933.10 Glyco_hydro_3 216596025064 Predicted methyltransferase [General function prediction only]; Region: COG3897 216596025065 Putative methyltransferase; Region: Methyltransf_16; pfam10294 216596025066 EVE domain; Region: EVE; cl00728 216596025067 Pfam match to entry PF04543.2 DUF589 216596025068 YciI-like protein; Reviewed; Region: PRK12865 216596025069 Pfam match to entry PF03795.3 YCII 216596025070 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 216596025071 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 216596025072 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 216596025073 Pfam match to entry PF07479.1 NAD_Gly3P_dh_C 216596025074 Pfam match to entry PF01210.10 NAD_Gly3P_dh_N 216596025075 1 probable transmembrane helix predicted at aa 7-29 216596025076 UGMP family protein; Validated; Region: PRK09604 216596025077 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 216596025078 Pfam match to entry PF00814.10 Peptidase_M22 216596025079 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 216596025080 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 216596025081 domain interfaces; other site 216596025082 active site 216596025083 Pfam match to entry PF01379.9 Porphobil_deam 216596025084 Pfam match to entry PF03900.4 Porphobil_deamC 216596025085 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 216596025086 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 216596025087 active site 216596025088 Pfam match to entry PF02602.4 HEM4 216596025089 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223 216596025090 1 probable transmembrane helix predicted at aa 108-130 216596025091 Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898 216596025092 HemY protein N-terminus; Region: HemY_N; pfam07219 216596025093 3 probable transmembrane helices predicted at aa 19-41, 61-83 and 103-122 216596025094 Pfam match to entry PF07219.1 HemY_N 216596025095 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 216596025096 putative metal binding site [ion binding]; other site 216596025097 Pfam match to entry PF07049.1 DUF1332 216596025098 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 216596025099 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 216596025100 catalytic triad [active] 216596025101 Pfam match to entry PF00117.10 GATase 216596025102 enterobactin exporter EntS; Provisional; Region: PRK10489 216596025103 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596025104 putative substrate translocation pore; other site 216596025105 8 probable transmembrane helices predicted at aa 21-43, 48-70, 82-104, 170-192,225-247, 257-279, 286-308 and 371-393 216596025106 YGGT family; Region: YGGT; pfam02325 216596025107 Pfam match to entry PF02325.6 YGGT 216596025108 2 probable transmembrane helices predicted at aa 35-57 and 91-113 216596025109 hypothetical protein; Validated; Region: PRK01310 216596025110 Pfam match to entry PF02594.5 DUF167 216596025111 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 216596025112 dimer interface [polypeptide binding]; other site 216596025113 substrate binding site [chemical binding]; other site 216596025114 metal binding sites [ion binding]; metal-binding site 216596025115 Pfam match to entry PF00719.8 Pyrophosphatase 216596025116 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 216596025117 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216596025118 Coenzyme A binding pocket [chemical binding]; other site 216596025119 Pfam match to entry PF00583.9 Acetyltransf_1 216596025120 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 216596025121 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 216596025122 G1 box; other site 216596025123 putative GEF interaction site [polypeptide binding]; other site 216596025124 GTP/Mg2+ binding site [chemical binding]; other site 216596025125 Switch I region; other site 216596025126 G2 box; other site 216596025127 G3 box; other site 216596025128 Switch II region; other site 216596025129 G4 box; other site 216596025130 G5 box; other site 216596025131 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 216596025132 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 216596025133 Pfam match to entry PF00679.10 EFG_C 216596025134 Pfam match to entry PF03144.8 GTP_EFTU_D2 216596025135 Pfam match to entry PF00009.10 GTP_EFTU 216596025136 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 216596025137 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 216596025138 active site 216596025139 Zn binding site [ion binding]; other site 216596025140 Pfam match to entry PF01432.8 Peptidase_M3 216596025141 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 216596025142 6 probable transmembrane helices predicted at aa 10-32, 45-64, 69-91, 112-134,149-171 and 183-205 216596025143 Pfam match to entry PF01810.7 LysE 216596025144 phage integrase/recombinase,pseudogene; C-terminus from codon 230 is similar to Rhodopseudomonas palustris possible phage integrase/recombinase precursor. UniProt:Q6NA54_RHOPA (EMBL:BX572597) (280 aa); similarity:fasta; with=UniProt:Q6NA54_RHOPA (EMBL:BX572597); Rhodopseudomonas palustris.; Possible phage integrase/recombinase precursor.; length=280; id 62.500; 40 aa overlap; query 2-41; subject 230-269 216596025145 Predicted transcriptional regulators [Transcription]; Region: COG1733 216596025146 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 216596025147 Pfam match to entry PF01638.6 DUF24 216596025148 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216596025149 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216596025150 active site 216596025151 1 probable transmembrane helix predicted at aa 299-321 216596025152 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 216596025153 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 216596025154 P loop; other site 216596025155 Nucleotide binding site [chemical binding]; other site 216596025156 DTAP/Switch II; other site 216596025157 Switch I; other site 216596025158 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 216596025159 DTAP/Switch II; other site 216596025160 Switch I; other site 216596025161 Pfam match to entry PF02374.5 ArsA_ATPase 216596025162 Pfam match to entry PF02374.5 ArsA_ATPase 216596025163 argininosuccinate synthase; Provisional; Region: PRK13820 216596025164 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 216596025165 ANP binding site [chemical binding]; other site 216596025166 Substrate Binding Site II [chemical binding]; other site 216596025167 Substrate Binding Site I [chemical binding]; other site 216596025168 Pfam match to entry PF00764.7 Arginosuc_synth 216596025169 hypothetical protein; Provisional; Region: PRK06194 216596025170 classical (c) SDRs; Region: SDR_c; cd05233 216596025171 NAD(P) binding site [chemical binding]; other site 216596025172 active site 216596025173 Pfam match to entry PF00106.11 adh_short 216596025174 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 216596025175 6 probable transmembrane helices predicted at aa 20-42, 63-85, 89-111, 142-164,174-196 and 209-231 216596025176 Pfam match to entry PF01810.7 LysE 216596025177 1 probable transmembrane helix predicted at aa 7-29 216596025178 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 216596025179 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216596025180 Walker A/P-loop; other site 216596025181 ATP binding site [chemical binding]; other site 216596025182 Q-loop/lid; other site 216596025183 ABC transporter signature motif; other site 216596025184 Walker B; other site 216596025185 D-loop; other site 216596025186 H-loop/switch region; other site 216596025187 Pfam match to entry PF00005.11 ABC_tran 216596025188 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596025189 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 216596025190 TM-ABC transporter signature motif; other site 216596025191 8 probable transmembrane helices predicted at aa 5-27, 42-64, 85-107, 131-153,182-201, 211-230, 235-257 and 261-283 216596025192 Pfam match to entry PF02653.5 BPD_transp_2 216596025193 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 216596025194 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 216596025195 zinc binding site [ion binding]; other site 216596025196 putative ligand binding site [chemical binding]; other site 216596025197 Pfam match to entry PF04392.2 DUF534 216596025198 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 216596025199 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 216596025200 FeS/SAM binding site; other site 216596025201 Pfam match to entry PF04055.4 Radical_SAM 216596025202 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 216596025203 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216596025204 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 216596025205 DNA binding residues [nucleotide binding] 216596025206 Pfam match to entry PF04542.2 Sigma70_r2 216596025207 Pfam match to entry PF04545.3 Sigma70_r4 216596025208 Uncharacterized conserved protein [Function unknown]; Region: COG3339 216596025209 Pfam match to entry PF06803.1 DUF1232 216596025210 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 216596025211 aromatic arch; other site 216596025212 DCoH dimer interaction site [polypeptide binding]; other site 216596025213 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 216596025214 DCoH tetramer interaction site [polypeptide binding]; other site 216596025215 substrate binding site [chemical binding]; other site 216596025216 Pfam match to entry PF01329.7 Pterin_4a 216596025217 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 216596025218 Low molecular weight phosphatase family; Region: LMWPc; cd00115 216596025219 active site 216596025220 Pfam match to entry PF01451.6 LMWPc 216596025221 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 216596025222 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 216596025223 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 216596025224 Pfam match to entry PF02834.4 2_5_RNA_ligase 216596025225 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 216596025226 active site 216596025227 catalytic triad [active] 216596025228 oxyanion hole [active] 216596025229 switch loop; other site 216596025230 Pfam match to entry PF00657.10 Lipase_GDSL 216596025231 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 216596025232 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 216596025233 Walker A/P-loop; other site 216596025234 ATP binding site [chemical binding]; other site 216596025235 Q-loop/lid; other site 216596025236 ABC transporter signature motif; other site 216596025237 Walker B; other site 216596025238 D-loop; other site 216596025239 H-loop/switch region; other site 216596025240 Pfam match to entry PF00005.11 ABC_tran 216596025241 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 216596025242 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 216596025243 FtsX-like permease family; Region: FtsX; pfam02687 216596025244 FtsX-like permease family; Region: FtsX; pfam02687 216596025245 10 probable transmembrane helices predicted at aa 21-43, 267-289, 309-331, 358-380,401-423, 433-455, 479-501, 723-745, 776-798 and 813-835 216596025246 Pfam match to entry PF02687.7 FtsX 216596025247 Pfam match to entry PF02687.7 FtsX 216596025248 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 216596025249 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 216596025250 Pfam match to entry PF01027.9 UPF0005 216596025251 7 probable transmembrane helices predicted at aa 26-48, 63-85, 98-117, 122-141,148-170, 175-194 and 216-238 216596025252 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 216596025253 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216596025254 Coenzyme A binding pocket [chemical binding]; other site 216596025255 Pfam match to entry PF00583.9 Acetyltransf_1 216596025256 Protein of unknown function (DUF2794); Region: DUF2794; pfam10984 216596025257 Uncharacterized secreted protein [Function unknown]; Region: COG5429 216596025258 Pfam match to entry PF06764.1 DUF1223 216596025259 aconitate hydratase; Validated; Region: PRK09277 216596025260 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 216596025261 substrate binding site [chemical binding]; other site 216596025262 ligand binding site [chemical binding]; other site 216596025263 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 216596025264 substrate binding site [chemical binding]; other site 216596025265 Pfam match to entry PF00694.8 Aconitase_C 216596025266 Pfam match to entry PF00330.8 Aconitase 216596025267 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 216596025268 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216596025269 Walker A/P-loop; other site 216596025270 ATP binding site [chemical binding]; other site 216596025271 Q-loop/lid; other site 216596025272 ABC transporter signature motif; other site 216596025273 Walker B; other site 216596025274 D-loop; other site 216596025275 H-loop/switch region; other site 216596025276 Pfam match to entry PF00005.11 ABC_tran 216596025277 heme exporter protein CcmB; Region: ccmB; TIGR01190 216596025278 Pfam match to entry PF03379.3 CcmB 216596025279 6 probable transmembrane helices predicted at aa 13-35, 45-64, 87-109, 124-146,155-177 and 192-214 216596025280 heme exporter protein CcmC; Region: ccmC; TIGR01191 216596025281 Pfam match to entry PF01578.9 Cytochrom_C_asm 216596025282 6 probable transmembrane helices predicted at aa 27-49, 69-88, 100-119, 129-151,164-186 and 206-228 216596025283 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 216596025284 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 216596025285 catalytic residues [active] 216596025286 central insert; other site 216596025287 1 probable transmembrane helix predicted at aa 19-36 216596025288 hypothetical protein; Provisional; Region: PRK00944 216596025289 4 probable transmembrane helices predicted at aa 13-35, 65-84, 125-147 and 151-170 216596025290 intracellular septation protein A; Reviewed; Region: PRK00259 216596025291 Pfam match to entry PF04279.4 IspA 216596025292 6 probable transmembrane helices predicted at aa 21-41, 51-73, 80-102, 117-139,151-170 and 180-202 216596025293 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 216596025294 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 216596025295 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 216596025296 Pfam match to entry PF00448.10 SRP54 216596025297 Pfam match to entry PF02881.6 SRP54_N 216596025298 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 216596025299 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 216596025300 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 216596025301 FeS/SAM binding site; other site 216596025302 TRAM domain; Region: TRAM; cl01282 216596025303 Pfam match to entry PF04055.4 Radical_SAM 216596025304 Pfam match to entry PF00919.9 UPF0004 216596025305 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 216596025306 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 216596025307 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 216596025308 Pfam match to entry PF01678.7 DAP_epimerase 216596025309 Pfam match to entry PF01678.7 DAP_epimerase 216596025310 signal recognition particle protein; Provisional; Region: PRK10867 216596025311 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 216596025312 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 216596025313 P loop; other site 216596025314 GTP binding site [chemical binding]; other site 216596025315 Signal peptide binding domain; Region: SRP_SPB; pfam02978 216596025316 Pfam match to entry PF02881.6 SRP54_N 216596025317 Pfam match to entry PF00448.10 SRP54 216596025318 Pfam match to entry PF02978.5 SRP_SPB 216596025319 chorismate mutase; Provisional; Region: PRK09239 216596025320 Pfam match to entry PF01817.7 Chorismate_mut 216596025321 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 216596025322 Pfam match to entry PF00886.8 Ribosomal_S16 216596025323 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 216596025324 RimM N-terminal domain; Region: RimM; pfam01782 216596025325 PRC-barrel domain; Region: PRC; pfam05239 216596025326 Pfam match to entry PF01782.6 RimM 216596025327 Pfam match to entry PF05239.2 PRC 216596025328 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 216596025329 Pfam match to entry PF01746.7 tRNA_m1G_MT 216596025330 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 216596025331 Pfam match to entry PF01245.7 Ribosomal_L19 216596025332 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 216596025333 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 216596025334 substrate binding pocket [chemical binding]; other site 216596025335 membrane-bound complex binding site; other site 216596025336 hinge residues; other site 216596025337 Pfam match to entry PF00497.8 SBP_bac_3 216596025338 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596025339 dimer interface [polypeptide binding]; other site 216596025340 conserved gate region; other site 216596025341 putative PBP binding loops; other site 216596025342 ABC-ATPase subunit interface; other site 216596025343 4 probable transmembrane helices predicted at aa 17-39, 54-76, 97-119 and 238-260 216596025344 Pfam match to entry PF00528.10 BPD_transp_1 216596025345 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 216596025346 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 216596025347 substrate binding site [chemical binding]; other site 216596025348 ligand binding site [chemical binding]; other site 216596025349 Pfam match to entry PF00330.8 Aconitase 216596025350 1 probable transmembrane helix predicted at aa 13-35 216596025351 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 216596025352 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 216596025353 active site 216596025354 catalytic tetrad [active] 216596025355 Pfam match to entry PF00248.9 Aldo_ket_red 216596025356 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 216596025357 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 216596025358 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596025359 active site 216596025360 phosphorylation site [posttranslational modification] 216596025361 intermolecular recognition site; other site 216596025362 dimerization interface [polypeptide binding]; other site 216596025363 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216596025364 DNA binding site [nucleotide binding] 216596025365 Pfam match to entry PF00072.9 Response_reg 216596025366 Pfam match to entry PF00486.11 Trans_reg_C 216596025367 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 216596025368 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 216596025369 ligand binding site [chemical binding]; other site 216596025370 flexible hinge region; other site 216596025371 Pfam match to entry PF00027.13 cNMP_binding 216596025372 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 216596025373 putative catalytic site [active] 216596025374 putative phosphate binding site [ion binding]; other site 216596025375 active site 216596025376 metal binding site A [ion binding]; metal-binding site 216596025377 DNA binding site [nucleotide binding] 216596025378 putative AP binding site [nucleotide binding]; other site 216596025379 putative metal binding site B [ion binding]; other site 216596025380 Pfam match to entry PF03372.6 Exo_endo_phos 216596025381 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 216596025382 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 216596025383 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 216596025384 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 216596025385 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 216596025386 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 216596025387 Pfam match to entry PF01580.8 FtsK_SpoIIIE 216596025388 3 probable transmembrane helices predicted at aa 29-51, 77-99 and 156-178 216596025389 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 216596025390 Pfam match to entry PF00909.8 Ammonium_transp 216596025391 12 probable transmembrane helices predicted at aa 13-32, 52-74, 81-103, 147-169,176-198, 218-240, 252-274, 284-306, 318-337, 342-361,373-395 and 429-451 216596025392 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 216596025393 Nitrogen regulatory protein P-II; Region: P-II; smart00938 216596025394 Pfam match to entry PF00543.8 P-II 216596025395 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 216596025396 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 216596025397 active site 216596025398 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 216596025399 catalytic triad [active] 216596025400 dimer interface [polypeptide binding]; other site 216596025401 Pfam match to entry PF02551.4 Acyl_CoA_thio 216596025402 Pfam match to entry PF02551.4 Acyl_CoA_thio 216596025403 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333 216596025404 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 216596025405 Pfam match to entry PF01360.9 Monooxygenase 216596025406 Uncharacterized conserved protein [Function unknown]; Region: COG2835 216596025407 Pfam match to entry PF03966.4 DUF343 216596025408 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 216596025409 Pfam match to entry PF02190.5 LON 216596025410 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 216596025411 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 216596025412 catalytic residues [active] 216596025413 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216596025414 TPR motif; other site 216596025415 binding surface 216596025416 Pfam match to entry PF00085.8 Thioredoxin 216596025417 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 216596025418 putative deacylase active site [active] 216596025419 Pfam match to entry PF04073.3 YbaK 216596025420 Uncharacterized conserved protein [Function unknown]; Region: COG5476 216596025421 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 216596025422 MlrC C-terminus; Region: MlrC_C; pfam07171 216596025423 Pfam match to entry PF07364.1 DUF1485 216596025424 Pfam match to entry PF07171.1 MlrC_C 216596025425 Transcriptional regulators [Transcription]; Region: FadR; COG2186 216596025426 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596025427 DNA-binding site [nucleotide binding]; DNA binding site 216596025428 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 216596025429 Pfam match to entry PF00392.9 GntR 216596025430 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 216596025431 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_5; cd08511 216596025432 Pfam match to entry PF00496.8 SBP_bac_5 216596025433 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 216596025434 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596025435 dimer interface [polypeptide binding]; other site 216596025436 conserved gate region; other site 216596025437 putative PBP binding loops; other site 216596025438 ABC-ATPase subunit interface; other site 216596025439 6 probable transmembrane helices predicted at aa 13-35, 109-131, 144-166, 186-205,244-266 and 294-316 216596025440 Pfam match to entry PF00528.10 BPD_transp_1 216596025441 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 216596025442 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596025443 dimer interface [polypeptide binding]; other site 216596025444 conserved gate region; other site 216596025445 putative PBP binding loops; other site 216596025446 ABC-ATPase subunit interface; other site 216596025447 6 probable transmembrane helices predicted at aa 30-52, 96-118, 125-147, 152-171,203-225 and 257-279 216596025448 Pfam match to entry PF00528.10 BPD_transp_1 216596025449 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 216596025450 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 216596025451 Pfam match to entry PF01019.9 G_glu_transpept 216596025452 Uncharacterized conserved protein [Function unknown]; Region: COG3342 216596025453 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 216596025454 Pfam match to entry PF06267.1 DUF1028 216596025455 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 216596025456 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596025457 Walker A/P-loop; other site 216596025458 ATP binding site [chemical binding]; other site 216596025459 Q-loop/lid; other site 216596025460 ABC transporter signature motif; other site 216596025461 Walker B; other site 216596025462 D-loop; other site 216596025463 H-loop/switch region; other site 216596025464 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 216596025465 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596025466 Walker A/P-loop; other site 216596025467 ATP binding site [chemical binding]; other site 216596025468 Q-loop/lid; other site 216596025469 ABC transporter signature motif; other site 216596025470 Walker B; other site 216596025471 D-loop; other site 216596025472 H-loop/switch region; other site 216596025473 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 216596025474 Pfam match to entry PF00005.11 ABC_tran 216596025475 Pfam match to entry PF00005.11 ABC_tran 216596025476 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 216596025477 Putative glucoamylase; Region: Glycoamylase; pfam10091 216596025478 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 216596025479 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 216596025480 Walker A/P-loop; other site 216596025481 ATP binding site [chemical binding]; other site 216596025482 Q-loop/lid; other site 216596025483 ABC transporter signature motif; other site 216596025484 Walker B; other site 216596025485 D-loop; other site 216596025486 H-loop/switch region; other site 216596025487 TOBE domain; Region: TOBE_2; pfam08402 216596025488 Pfam match to entry PF00005.11 ABC_tran 216596025489 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 216596025490 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596025491 dimer interface [polypeptide binding]; other site 216596025492 conserved gate region; other site 216596025493 putative PBP binding loops; other site 216596025494 ABC-ATPase subunit interface; other site 216596025495 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596025496 dimer interface [polypeptide binding]; other site 216596025497 conserved gate region; other site 216596025498 putative PBP binding loops; other site 216596025499 ABC-ATPase subunit interface; other site 216596025500 Pfam match to entry PF00528.10 BPD_transp_1 216596025501 12 probable transmembrane helices predicted at aa 29-51, 71-93, 106-128, 138-160,190-212, 236-258, 279-301, 330-352, 364-386, 390-409,453-475 and 495-517 216596025502 Pfam match to entry PF00528.10 BPD_transp_1 216596025503 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 216596025504 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 216596025505 Pfam match to entry PF01547.11 SBP_bac_1 216596025506 aldehyde dehydrogenase family 7 member; Region: PLN02315 216596025507 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 216596025508 tetrameric interface [polypeptide binding]; other site 216596025509 NAD binding site [chemical binding]; other site 216596025510 catalytic residues [active] 216596025511 Pfam match to entry PF00171.9 Aldedh 216596025512 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 216596025513 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 216596025514 Pfam match to entry PF01266.8 DAO 216596025515 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 216596025516 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 216596025517 Pfam match to entry PF07063.1 DUF1338 216596025518 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 216596025519 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596025520 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 216596025521 dimerization interface [polypeptide binding]; other site 216596025522 substrate binding pocket [chemical binding]; other site 216596025523 Pfam match to entry PF00126.10 HTH_1 216596025524 Pfam match to entry PF03466.5 LysR_substrate 216596025525 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 216596025526 AsnC family; Region: AsnC_trans_reg; pfam01037 216596025527 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 216596025528 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 216596025529 Pfam match to entry PF00534.8 Glycos_transf_1 216596025530 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 216596025531 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 216596025532 exosortase A system-associated hydrolase 2; Region: hydr2_PEP; TIGR03101 216596025533 exosortase A system-associated hydrolase 1; Region: hydr1_PEP; TIGR03100 216596025534 13 probable transmembrane helices predicted at aa 13-35, 40-62, 85-107, 122-144,151-173, 178-200, 207-229, 239-261, 300-322, 332-354,363-385, 417-439 and 446-468 216596025535 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 216596025536 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 216596025537 Pfam match to entry PF00534.8 Glycos_transf_1 216596025538 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 216596025539 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 216596025540 Pfam match to entry PF02837.6 Glyco_hydro_2_N 216596025541 Domain of unknown function (DUF1839); Region: DUF1839; pfam08893 216596025542 Gly_His_Pro_Ser_Thr_tRNA synthetase class II core domain. This domain is the core catalytic domain of tRNA synthetases of the subgroup containing glycyl, histidyl, prolyl, seryl and threonyl tRNA synthetases. It is primarily responsible for ATP-dependent...; Region: Gly_His_Pro_Ser_Thr_tRS_core; cd00670 216596025543 dimer interface [polypeptide binding]; other site 216596025544 motif 1; other site 216596025545 active site 216596025546 motif 2; other site 216596025547 motif 3; other site 216596025548 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216596025549 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216596025550 active site 216596025551 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216596025552 active site 216596025553 Pfam match to entry PF02771.6 Acyl-CoA_dh_N 216596025554 acyl carrier protein; Provisional; Region: PRK07081 216596025555 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 216596025556 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 216596025557 FeS/SAM binding site; other site 216596025558 Pfam match to entry PF04055.4 Radical_SAM 216596025559 Truncated, possibly inactive, lysyl-tRNA synthetase (class II) [Translation, ribosomal structure and biogenesis]; Region: COG2269 216596025560 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 216596025561 motif 1; other site 216596025562 dimer interface [polypeptide binding]; other site 216596025563 active site 216596025564 motif 2; other site 216596025565 motif 3; other site 216596025566 Pfam match to entry PF00152.8 tRNA-synt_2 216596025567 elongation factor P; Validated; Region: PRK00529 216596025568 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 216596025569 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 216596025570 RNA binding site [nucleotide binding]; other site 216596025571 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 216596025572 RNA binding site [nucleotide binding]; other site 216596025573 Pfam match to entry PF01132.7 EFP 216596025574 hypothetical protein; Provisional; Region: PRK02947 216596025575 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 216596025576 putative active site [active] 216596025577 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 216596025578 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 216596025579 active site 216596025580 dimer interface [polypeptide binding]; other site 216596025581 Pfam match to entry PF01979.7 Amidohydro_1 216596025582 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 216596025583 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 216596025584 dimer interface [polypeptide binding]; other site 216596025585 active site 216596025586 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 216596025587 dimer interface [polypeptide binding]; other site 216596025588 active site 216596025589 Pfam match to entry PF01380.9 SIS 216596025590 Pfam match to entry PF01380.9 SIS 216596025591 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 216596025592 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596025593 DNA-binding site [nucleotide binding]; DNA binding site 216596025594 UTRA domain; Region: UTRA; pfam07702 216596025595 Pfam match to entry PF00392.9 GntR 216596025596 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 216596025597 active site 216596025598 catalytic residues [active] 216596025599 Pfam match to entry PF01263.8 Aldose_epim 216596025600 homoserine O-succinyltransferase; Provisional; Region: PRK05368 216596025601 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 216596025602 proposed active site lysine [active] 216596025603 conserved cys residue [active] 216596025604 Pfam match to entry PF04204.2 HTS 216596025605 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 216596025606 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 216596025607 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 216596025608 5 probable transmembrane helices predicted at aa 56-78, 98-120, 176-198, 213-235 and 303-325 216596025609 Pfam match to entry PF00664.9 ABC_membrane 216596025610 1 probable transmembrane helix predicted at aa 20-39 216596025611 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 216596025612 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 216596025613 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 216596025614 Pfam match to entry PF00005.11 ABC_tran 216596025615 Pfam match to entry PF00005.11 ABC_tran 216596025616 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 216596025617 Thiamine pyrophosphokinase; Region: TPK; cd07995 216596025618 active site 216596025619 dimerization interface [polypeptide binding]; other site 216596025620 thiamine binding site [chemical binding]; other site 216596025621 Pfam match to entry PF04263.4 TPK_catalytic 216596025622 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 216596025623 MarR family; Region: MarR_2; pfam12802 216596025624 MarR family; Region: MarR_2; cl17246 216596025625 Pfam match to entry PF01047.8 MarR 216596025626 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596025627 putative substrate translocation pore; other site 216596025628 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596025629 putative substrate translocation pore; other site 216596025630 13 probable transmembrane helices predicted at aa 20-42, 55-77, 84-106, 110-132,145-164, 174-193, 206-223, 233-255, 276-298, 308-327,340-359, 364-386 and 467-489 216596025631 Pfam match to entry PF00083.9 Sugar_tr 216596025632 Putative Zn-dependent protease [General function prediction only]; Region: COG4784 216596025633 Peptidase family M48; Region: Peptidase_M48; pfam01435 216596025634 Pfam match to entry PF01435.7 Peptidase_M48 216596025635 RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500 216596025636 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216596025637 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 216596025638 DNA binding residues [nucleotide binding] 216596025639 Pfam match to entry PF04545.3 Sigma70_r4 216596025640 Pfam match to entry PF04542.2 Sigma70_r2 216596025641 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 216596025642 Pfam match to entry PF02559.4 CarD_TRCF 216596025643 Ferredoxin [Energy production and conversion]; Region: COG1146 216596025644 4Fe-4S binding domain; Region: Fer4; cl02805 216596025645 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 216596025646 Pfam match to entry PF00037.11 Fer4 216596025647 Pfam match to entry PF00037.11 Fer4 216596025648 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 216596025649 RNA binding surface [nucleotide binding]; other site 216596025650 Pfam match to entry PF01479.9 S4 216596025651 DEAD/DEAH box helicase; Region: DEAD; pfam00270 216596025652 ATP binding site [chemical binding]; other site 216596025653 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 216596025654 putative Mg++ binding site [ion binding]; other site 216596025655 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 216596025656 nucleotide binding region [chemical binding]; other site 216596025657 ATP-binding site [chemical binding]; other site 216596025658 Pfam match to entry PF00271.13 Helicase_C 216596025659 Pfam match to entry PF00270.12 DEAD 216596025660 2 probable transmembrane helices predicted at aa 5-27 and 42-64 216596025661 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 216596025662 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 216596025663 NAD(P) binding site [chemical binding]; other site 216596025664 homotetramer interface [polypeptide binding]; other site 216596025665 homodimer interface [polypeptide binding]; other site 216596025666 active site 216596025667 Pfam match to entry PF00106.11 adh_short 216596025668 putative acyltransferase; Provisional; Region: PRK05790 216596025669 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 216596025670 dimer interface [polypeptide binding]; other site 216596025671 active site 216596025672 Pfam match to entry PF02803.5 Thiolase_C 216596025673 Pfam match to entry PF00108.10 Thiolase_N 216596025674 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 216596025675 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 216596025676 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 216596025677 Pfam match to entry PF05233.1 PHB_acc 216596025678 4 probable transmembrane helices predicted at aa 4-26, 47-69, 79-99 and 106-128 216596025679 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 216596025680 Pfam match to entry PF01783.9 Ribosomal_L32p 216596025681 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 216596025682 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 216596025683 putative C-terminal domain interface [polypeptide binding]; other site 216596025684 putative GSH binding site (G-site) [chemical binding]; other site 216596025685 putative dimer interface [polypeptide binding]; other site 216596025686 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 216596025687 putative N-terminal domain interface [polypeptide binding]; other site 216596025688 putative dimer interface [polypeptide binding]; other site 216596025689 putative substrate binding pocket (H-site) [chemical binding]; other site 216596025690 Pfam match to entry PF02798.6 GST_N 216596025691 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5255 216596025692 Domain of unknown function (DUF1868); Region: 2H-phosphodiest; pfam08975 216596025693 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 216596025694 Transglycosylase; Region: Transgly; cl17702 216596025695 Pfam match to entry PF00912.8 Transgly 216596025696 1 probable transmembrane helix predicted at aa 29-51 216596025697 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 216596025698 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 216596025699 substrate binding pocket [chemical binding]; other site 216596025700 chain length determination region; other site 216596025701 substrate-Mg2+ binding site; other site 216596025702 catalytic residues [active] 216596025703 aspartate-rich region 1; other site 216596025704 active site lid residues [active] 216596025705 aspartate-rich region 2; other site 216596025706 Pfam match to entry PF00348.7 polyprenyl_synt 216596025707 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 216596025708 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216596025709 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596025710 homodimer interface [polypeptide binding]; other site 216596025711 catalytic residue [active] 216596025712 Pfam match to entry PF00155.8 Aminotran_1_2 216596025713 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 216596025714 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 216596025715 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 216596025716 Pfam match to entry PF04551.3 GcpE 216596025717 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596025718 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216596025719 putative substrate translocation pore; other site 216596025720 12 probable transmembrane helices predicted at aa 21-40, 55-77, 84-106, 111-133,146-165, 170-192, 212-234, 244-266, 279-298, 302-324,336-358 and 362-384 216596025721 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 216596025722 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 216596025723 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 216596025724 Pfam match to entry PF00455.10 DeoR 216596025725 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 216596025726 EamA-like transporter family; Region: EamA; pfam00892 216596025727 10 probable transmembrane helices predicted at aa 52-74, 80-102, 115-137, 142-164,171-193, 198-215, 228-247, 252-274, 281-303 and 308-327 216596025728 Pfam match to entry PF00892.8 DUF6 216596025729 Pfam match to entry PF00892.8 DUF6 216596025730 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 216596025731 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 216596025732 substrate binding pocket [chemical binding]; other site 216596025733 membrane-bound complex binding site; other site 216596025734 hinge residues; other site 216596025735 Pfam match to entry PF00497.8 SBP_bac_3 216596025736 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 216596025737 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596025738 dimer interface [polypeptide binding]; other site 216596025739 conserved gate region; other site 216596025740 putative PBP binding loops; other site 216596025741 ABC-ATPase subunit interface; other site 216596025742 4 probable transmembrane helices predicted at aa 15-37, 58-80, 84-103 and 187-209 216596025743 Pfam match to entry PF00528.10 BPD_transp_1 216596025744 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 216596025745 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 216596025746 Walker A/P-loop; other site 216596025747 ATP binding site [chemical binding]; other site 216596025748 Q-loop/lid; other site 216596025749 ABC transporter signature motif; other site 216596025750 Walker B; other site 216596025751 D-loop; other site 216596025752 H-loop/switch region; other site 216596025753 Pfam match to entry PF00005.11 ABC_tran 216596025754 Predicted flavoprotein [General function prediction only]; Region: COG0431 216596025755 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 216596025756 Pfam match to entry PF03358.3 FMN_red 216596025757 pyruvate carboxylase; Reviewed; Region: PRK12999 216596025758 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 216596025759 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 216596025760 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 216596025761 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 216596025762 active site 216596025763 catalytic residues [active] 216596025764 metal binding site [ion binding]; metal-binding site 216596025765 homodimer binding site [polypeptide binding]; other site 216596025766 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 216596025767 carboxyltransferase (CT) interaction site; other site 216596025768 biotinylation site [posttranslational modification]; other site 216596025769 Pfam match to entry PF00364.9 Biotin_lipoyl 216596025770 Pfam match to entry PF02436.5 PYC_OADA 216596025771 Pfam match to entry PF00682.8 HMGL-like 216596025772 Pfam match to entry PF02785.5 Biotin_carb_C 216596025773 Pfam match to entry PF02786.4 CPSase_L_D2 216596025774 Pfam match to entry PF00289.9 CPSase_L_chain 216596025775 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 216596025776 Autoinducer binding domain; Region: Autoind_bind; pfam03472 216596025777 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216596025778 DNA binding residues [nucleotide binding] 216596025779 dimerization interface [polypeptide binding]; other site 216596025780 Pfam match to entry PF00196.8 GerE 216596025781 Pfam match to entry PF03472.4 Autoind_bind 216596025782 cyclic beta-1,2-glucan ABC transporter; Provisional; Region: PRK13657 216596025783 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 216596025784 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 216596025785 Walker A/P-loop; other site 216596025786 ATP binding site [chemical binding]; other site 216596025787 Q-loop/lid; other site 216596025788 ABC transporter signature motif; other site 216596025789 Walker B; other site 216596025790 D-loop; other site 216596025791 H-loop/switch region; other site 216596025792 5 probable transmembrane helices predicted at aa 21-43, 58-77, 126-148, 158-177 and 248-270 216596025793 Pfam match to entry PF00664.9 ABC_membrane 216596025794 Pfam match to entry PF00005.11 ABC_tran 216596025795 Similar to codon 35 to the C-terminus of Pantoea agglomerans transposase A. UniProt:Q9AM92_9ENTR (EMBL:AF327444) (149 aa), and similar to codons 35 to the C-terminus of Nitrosomonas europaea transposase. UniProt:Q81ZK8_NITEU (EMBL:BX321857) (122 aa); similarity:fasta; with=UniProt:Q9AM92_9ENTR (EMBL:AF327444); Pantoea agglomerans.; transposase A.; length=149; id 37.755; 98 aa overlap; query 1-88; subject 36-133; similarity:fasta; with=UniProt:Q81ZK8_NITEU (EMBL:BX321857); Nitrosomonas europaea.; Transposase.; length=122; id 71.591; 88 aa overlap; query 1-88; subject 34-121; transposase, pseudogene 216596025796 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238 216596025797 dimer interface [polypeptide binding]; other site 216596025798 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216596025799 Pfam match to entry PF00903.11 Glyoxalase 216596025800 OpgC protein; Region: OpgC_C; pfam10129 216596025801 Acyltransferase family; Region: Acyl_transf_3; pfam01757 216596025802 Pfam match to entry PF01757.9 Acyl_transf_3 216596025803 10 probable transmembrane helices predicted at aa 107-129, 139-157, 178-200,232-254, 261-278, 288-310, 322-344, 369-391, 404-426 and 431-451 216596025804 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 216596025805 Putative glucoamylase; Region: Glycoamylase; pfam10091 216596025806 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 216596025807 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 216596025808 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 216596025809 Protein of unknown function, DUF608; Region: DUF608; pfam04685 216596025810 Pfam match to entry PF06205.1 GT36_AF 216596025811 Pfam match to entry PF06165.1 Glyco_transf_36 216596025812 Pfam match to entry PF06204.1 CBM_X 216596025813 Pfam match to entry PF06205.1 GT36_AF 216596025814 Pfam match to entry PF06165.1 Glyco_transf_36 216596025815 Pfam match to entry PF06204.1 CBM_X 216596025816 6 probable transmembrane helices predicted at aa 408-427, 440-462, 830-852,865-887, 934-951 and 956-978 216596025817 1 probable transmembrane helix predicted at aa 31-53 216596025818 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 216596025819 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596025820 Walker A/P-loop; other site 216596025821 ATP binding site [chemical binding]; other site 216596025822 Q-loop/lid; other site 216596025823 ABC transporter signature motif; other site 216596025824 Walker B; other site 216596025825 D-loop; other site 216596025826 H-loop/switch region; other site 216596025827 Pfam match to entry PF00005.11 ABC_tran 216596025828 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 216596025829 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596025830 Walker A/P-loop; other site 216596025831 ATP binding site [chemical binding]; other site 216596025832 Q-loop/lid; other site 216596025833 ABC transporter signature motif; other site 216596025834 Walker B; other site 216596025835 D-loop; other site 216596025836 H-loop/switch region; other site 216596025837 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216596025838 Pfam match to entry PF00005.11 ABC_tran 216596025839 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 216596025840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596025841 dimer interface [polypeptide binding]; other site 216596025842 conserved gate region; other site 216596025843 putative PBP binding loops; other site 216596025844 ABC-ATPase subunit interface; other site 216596025845 Pfam match to entry PF00528.10 BPD_transp_1 216596025846 5 probable transmembrane helices predicted at aa 45-67, 110-132, 158-180, 229-251 and 275-297 216596025847 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 216596025848 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596025849 dimer interface [polypeptide binding]; other site 216596025850 conserved gate region; other site 216596025851 putative PBP binding loops; other site 216596025852 ABC-ATPase subunit interface; other site 216596025853 Pfam match to entry PF00528.10 BPD_transp_1 216596025854 6 probable transmembrane helices predicted at aa 23-45, 118-140, 153-175, 218-237,276-298 and 323-345 216596025855 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 216596025856 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 216596025857 Pfam match to entry PF00496.8 SBP_bac_5 216596025858 1 probable transmembrane helix predicted at aa 39-61 216596025859 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 216596025860 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 216596025861 active site 216596025862 dimer interface [polypeptide binding]; other site 216596025863 Pfam match to entry PF01244.7 Renal_dipeptase 216596025864 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596025865 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216596025866 TM-ABC transporter signature motif; other site 216596025867 Pfam match to entry PF02653.5 BPD_transp_2 216596025868 8 probable transmembrane helices predicted at aa 25-47, 57-79, 86-105, 120-142,147-164, 187-204, 234-256 and 289-311 216596025869 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 216596025870 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 216596025871 Walker A/P-loop; other site 216596025872 ATP binding site [chemical binding]; other site 216596025873 Q-loop/lid; other site 216596025874 ABC transporter signature motif; other site 216596025875 Walker B; other site 216596025876 D-loop; other site 216596025877 H-loop/switch region; other site 216596025878 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 216596025879 Pfam match to entry PF00005.11 ABC_tran 216596025880 Pfam match to entry PF00005.11 ABC_tran 216596025881 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 216596025882 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 216596025883 putative ligand binding site [chemical binding]; other site 216596025884 Pfam match to entry PF00532.8 Peripla_BP_1 216596025885 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 216596025886 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 216596025887 Sulfatase; Region: Sulfatase; cl17466 216596025888 Pfam match to entry PF00884.10 Sulfatase 216596025889 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 216596025890 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 216596025891 NAD binding site [chemical binding]; other site 216596025892 homodimer interface [polypeptide binding]; other site 216596025893 active site 216596025894 substrate binding site [chemical binding]; other site 216596025895 Pfam match to entry PF01370.8 Epimerase 216596025896 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 216596025897 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216596025898 Coenzyme A binding pocket [chemical binding]; other site 216596025899 Pfam match to entry PF00583.9 Acetyltransf_1 216596025900 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 216596025901 Thioredoxin; Region: Thioredoxin_4; cl17273 216596025902 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 216596025903 10 probable transmembrane helices predicted at aa 25-47, 119-141, 176-198, 213-231,238-260, 270-287, 300-322, 332-354, 361-383 and 393-412 216596025904 Predicted helicase [General function prediction only]; Region: COG4889 216596025905 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 216596025906 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 216596025907 catalytic residues [active] 216596025908 catalytic nucleophile [active] 216596025909 Presynaptic Site I dimer interface [polypeptide binding]; other site 216596025910 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 216596025911 Synaptic Flat tetramer interface [polypeptide binding]; other site 216596025912 Synaptic Site I dimer interface [polypeptide binding]; other site 216596025913 DNA binding site [nucleotide binding] 216596025914 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 216596025915 DNA-binding interface [nucleotide binding]; DNA binding site 216596025916 Pfam match to entry PF00239.10 Resolvase 216596025917 2 probable transmembrane helices predicted at aa 40-59 and 69-91 216596025918 similarity:fasta; with=UniProt:Q5BB78_EMENI (EMBL:AACD01000035); Aspergillus nidulans FGSC A4.; Predicted protein.; length=120; id 39.535; 43 aa overlap; query 32-72; subject 17-57 216596025919 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 216596025920 active site 216596025921 DNA binding site [nucleotide binding] 216596025922 Int/Topo IB signature motif; other site 216596025923 Pfam match to entry PF00589.8 Phage_integrase 216596025924 Domain of unknown function (DUF955); Region: DUF955; cl01076 216596025925 Pfam match to entry PF01381.9 HTH_3 216596025926 Pfam match to entry PF06114.2 DUF955 216596025927 conserved hypothetical protein, pseudogene; Similar to codons 50 to the C-terminus of Pseudomonas putida (strain KT2440) hypothetical protein. UniProt:Q88NM9_PSEPK (EMBL:AE016778) (87 aa); similarity:fasta; with=UniProt:Q88NM9_PSEPK (EMBL:AE016778); Pseudomonas putida (strain KT2440).; Hypothetical protein.; length=87; id 61.290; 31 aa overlap; query 4-34; subject 52-82 216596025928 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 216596025929 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 216596025930 Pfam match to entry PF00829.9 Ribosomal_L21p 216596025931 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 216596025932 Pfam match to entry PF01016.7 Ribosomal_L27 216596025933 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 216596025934 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 216596025935 Pfam match to entry PF00583.9 Acetyltransf_1 216596025936 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 216596025937 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 216596025938 Pfam match to entry PF00583.9 Acetyltransf_1 216596025939 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 216596025940 putative catalytic site [active] 216596025941 putative metal binding site [ion binding]; other site 216596025942 putative phosphate binding site [ion binding]; other site 216596025943 Pfam match to entry PF03372.6 Exo_endo_phos 216596025944 GTPase CgtA; Reviewed; Region: obgE; PRK12299 216596025945 GTP1/OBG; Region: GTP1_OBG; pfam01018 216596025946 Obg GTPase; Region: Obg; cd01898 216596025947 G1 box; other site 216596025948 GTP/Mg2+ binding site [chemical binding]; other site 216596025949 Switch I region; other site 216596025950 G2 box; other site 216596025951 G3 box; other site 216596025952 Switch II region; other site 216596025953 G4 box; other site 216596025954 G5 box; other site 216596025955 Pfam match to entry PF01018.10 GTP1_OBG 216596025956 gamma-glutamyl kinase; Provisional; Region: PRK05429 216596025957 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 216596025958 nucleotide binding site [chemical binding]; other site 216596025959 homotetrameric interface [polypeptide binding]; other site 216596025960 putative phosphate binding site [ion binding]; other site 216596025961 putative allosteric binding site; other site 216596025962 PUA domain; Region: PUA; pfam01472 216596025963 Pfam match to entry PF00696.12 AA_kinase 216596025964 Pfam match to entry PF01472.6 PUA 216596025965 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 216596025966 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 216596025967 putative catalytic cysteine [active] 216596025968 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 216596025969 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 216596025970 active site 216596025971 (T/H)XGH motif; other site 216596025972 Pfam match to entry PF01467.12 CTP_transf_2 216596025973 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 216596025974 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 216596025975 Pfam match to entry PF01547.11 SBP_bac_1 216596025976 1 probable transmembrane helix predicted at aa 7-29 216596025977 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596025978 dimer interface [polypeptide binding]; other site 216596025979 conserved gate region; other site 216596025980 putative PBP binding loops; other site 216596025981 ABC-ATPase subunit interface; other site 216596025982 Pfam match to entry PF00528.10 BPD_transp_1 216596025983 5 probable transmembrane helices predicted at aa 54-73, 86-108, 123-145, 166-188 and 235-257 216596025984 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216596025985 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 216596025986 Walker A/P-loop; other site 216596025987 ATP binding site [chemical binding]; other site 216596025988 Q-loop/lid; other site 216596025989 ABC transporter signature motif; other site 216596025990 Walker B; other site 216596025991 D-loop; other site 216596025992 H-loop/switch region; other site 216596025993 TOBE domain; Region: TOBE; pfam03459 216596025994 Pfam match to entry PF00005.11 ABC_tran 216596025995 Pfam match to entry PF03459.4 TOBE 216596025996 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 216596025997 Pfam match to entry PF00126.10 HTH_1 216596025998 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 216596025999 Pfam match to entry PF02410.5 DUF143 216596026000 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 216596026001 Pfam match to entry PF02590.5 DUF163 216596026002 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 216596026003 Peptidase family M23; Region: Peptidase_M23; pfam01551 216596026004 Pfam match to entry PF01551.6 Peptidase_M23 216596026005 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 216596026006 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 216596026007 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 216596026008 protein binding site [polypeptide binding]; other site 216596026009 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 216596026010 Catalytic dyad [active] 216596026011 1 probable transmembrane helix predicted at aa 7-29 216596026012 Pfam match to entry PF00595.8 PDZ 216596026013 Pfam match to entry PF03572.6 Peptidase_S41 216596026014 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 216596026015 NodB motif; other site 216596026016 putative active site [active] 216596026017 putative catalytic site [active] 216596026018 Zn binding site [ion binding]; other site 216596026019 1 probable transmembrane helix predicted at aa 13-35 216596026020 Pfam match to entry PF04748.2 Polysacc_deac_2 216596026021 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 216596026022 putative active site [active] 216596026023 Ap4A binding site [chemical binding]; other site 216596026024 nudix motif; other site 216596026025 putative metal binding site [ion binding]; other site 216596026026 Pfam match to entry PF00293.12 NUDIX 216596026027 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 216596026028 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 216596026029 heme binding site [chemical binding]; other site 216596026030 ferroxidase pore; other site 216596026031 ferroxidase diiron center [ion binding]; other site 216596026032 Pfam match to entry PF00210.9 Ferritin 216596026033 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 216596026034 Pfam match to entry PF04324.3 Fer2_BFD 216596026035 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 216596026036 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 216596026037 putative active site [active] 216596026038 putative PHP Thumb interface [polypeptide binding]; other site 216596026039 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 216596026040 generic binding surface II; other site 216596026041 generic binding surface I; other site 216596026042 Pfam match to entry PF01336.9 tRNA_anti 216596026043 Pfam match to entry PF02231.5 PHP_N 216596026044 DNA Polymerase Y-family; Region: PolY_like; cd03468 216596026045 active site 216596026046 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 216596026047 DNA binding site [nucleotide binding] 216596026048 Uncharacterized conserved protein [Function unknown]; Region: COG4544 216596026049 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 216596026050 Pfam match to entry PF06262.1 DUF1025 216596026051 Uncharacterized conserved small protein [Function unknown]; Region: COG5515 216596026052 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 216596026053 1 probable transmembrane helix predicted at aa 50-83 216596026054 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 216596026055 putative dimer interface [polypeptide binding]; other site 216596026056 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216596026057 Pfam match to entry PF00903.11 Glyoxalase 216596026058 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 216596026059 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 216596026060 substrate binding site [chemical binding]; other site 216596026061 Pfam match to entry PF00694.8 Aconitase_C 216596026062 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 216596026063 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 216596026064 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216596026065 catalytic residue [active] 216596026066 Pfam match to entry PF00291.10 PALP 216596026067 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 216596026068 tartrate dehydrogenase; Region: TTC; TIGR02089 216596026069 Pfam match to entry PF00180.7 Iso_dh 216596026070 PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389 216596026071 active site 216596026072 6 probable transmembrane helices predicted at aa 21-43, 58-80, 100-122, 154-173,178-195 and 205-227 216596026073 Pfam match to entry PF01569.9 PAP2 216596026074 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596026075 putative substrate translocation pore; other site 216596026076 10 probable transmembrane helices predicted at aa 61-83, 98-120, 127-149, 164-186,193-215, 249-271, 284-306, 316-333, 527-549 and 594-616 216596026077 Pfam match to entry PF00083.9 Sugar_tr 216596026078 FtsX-like permease family; Region: FtsX; pfam02687 216596026079 Pfam match to entry PF02687.7 FtsX 216596026080 4 probable transmembrane helices predicted at aa 12-34, 307-329, 350-382 and 402-424 216596026081 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 216596026082 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 216596026083 Walker A/P-loop; other site 216596026084 ATP binding site [chemical binding]; other site 216596026085 Q-loop/lid; other site 216596026086 ABC transporter signature motif; other site 216596026087 Walker B; other site 216596026088 D-loop; other site 216596026089 H-loop/switch region; other site 216596026090 Pfam match to entry PF00005.11 ABC_tran 216596026091 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 216596026092 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 216596026093 dimer interface [polypeptide binding]; other site 216596026094 active site 216596026095 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 216596026096 Pfam match to entry PF00245.9 Alk_phosphatase 216596026097 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 216596026098 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 216596026099 Pfam match to entry PF01118.10 Semialdhyde_dh 216596026100 Pfam match to entry PF02774.6 Semialdhyde_dhC 216596026101 Transglycosylase SLT domain; Region: SLT_2; pfam13406 216596026102 murein hydrolase B; Provisional; Region: PRK10760; cl17906 216596026103 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 216596026104 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216596026105 metal binding site [ion binding]; metal-binding site 216596026106 active site 216596026107 I-site; other site 216596026108 Pfam match to entry PF00990.8 GGDEF 216596026109 2 probable transmembrane helices predicted at aa 12-31 and 305-327 216596026110 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 216596026111 active site clefts [active] 216596026112 zinc binding site [ion binding]; other site 216596026113 dimer interface [polypeptide binding]; other site 216596026114 Pfam match to entry PF00484.8 Pro_CA 216596026115 pyridoxamine kinase; Validated; Region: PRK05756 216596026116 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 216596026117 pyridoxal binding site [chemical binding]; other site 216596026118 dimer interface [polypeptide binding]; other site 216596026119 ATP binding site [chemical binding]; other site 216596026120 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 216596026121 Pfam match to entry PF05088.2 Bac_GDH 216596026122 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 216596026123 12 probable transmembrane helices predicted at aa 20-42, 57-79, 92-111, 115-137,158-180, 203-225, 271-290, 294-313, 325-347, 362-384,405-427 and 431-453 216596026124 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 216596026125 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 216596026126 purine monophosphate binding site [chemical binding]; other site 216596026127 dimer interface [polypeptide binding]; other site 216596026128 putative catalytic residues [active] 216596026129 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 216596026130 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 216596026131 Pfam match to entry PF01808.7 AICARFT_IMPCHas 216596026132 Pfam match to entry PF02142.8 MGS 216596026133 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 216596026134 NusB family; Region: NusB; pfam01029 216596026135 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 216596026136 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 216596026137 Pfam match to entry PF01189.7 Nol1_Nop2_Fmu 216596026138 Pfam match to entry PF01029.8 NusB 216596026139 heat shock protein HtpX; Provisional; Region: PRK01345 216596026140 Pfam match to entry PF01435.7 Peptidase_M48 216596026141 4 probable transmembrane helices predicted at aa 7-24, 28-47, 143-165 and 175-197 216596026142 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 216596026143 Uncharacterized conserved small protein [Function unknown]; Region: COG5508 216596026144 acetyl-CoA synthetase; Provisional; Region: PRK00174 216596026145 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 216596026146 active site 216596026147 CoA binding site [chemical binding]; other site 216596026148 acyl-activating enzyme (AAE) consensus motif; other site 216596026149 AMP binding site [chemical binding]; other site 216596026150 acetate binding site [chemical binding]; other site 216596026151 Pfam match to entry PF00501.11 AMP-binding 216596026152 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3820 216596026153 Pfam match to entry PF06242.1 DUF1013 216596026154 flagellin; Reviewed; Region: PRK12687 216596026155 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 216596026156 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 216596026157 Pfam match to entry PF00700.8 Flagellin_C 216596026158 Pfam match to entry PF00669.8 Flagellin_N 216596026159 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 216596026160 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 216596026161 acyl-activating enzyme (AAE) consensus motif; other site 216596026162 putative AMP binding site [chemical binding]; other site 216596026163 putative active site [active] 216596026164 putative CoA binding site [chemical binding]; other site 216596026165 Pfam match to entry PF00501.11 AMP-binding 216596026166 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 216596026167 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 216596026168 catalytic residue [active] 216596026169 Pfam match to entry PF01168.8 Ala_racemase_N 216596026170 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 216596026171 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 216596026172 HIGH motif; other site 216596026173 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 216596026174 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 216596026175 active site 216596026176 KMSKS motif; other site 216596026177 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 216596026178 tRNA binding surface [nucleotide binding]; other site 216596026179 Pfam match to entry PF00133.8 tRNA-synt_1 216596026180 Lipopolysaccharide-assembly; Region: LptE; cl01125 216596026181 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 216596026182 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 216596026183 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 216596026184 ParB-like nuclease domain; Region: ParBc; pfam02195 216596026185 KorB domain; Region: KorB; pfam08535 216596026186 Pfam match to entry PF02195.5 ParBc 216596026187 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 216596026188 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 216596026189 P-loop; other site 216596026190 Magnesium ion binding site [ion binding]; other site 216596026191 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 216596026192 Magnesium ion binding site [ion binding]; other site 216596026193 Pfam match to entry PF00991.7 ParA 216596026194 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 216596026195 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 216596026196 Pfam match to entry PF02527.4 GidB 216596026197 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 216596026198 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 216596026199 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 216596026200 Pfam match to entry PF01134.9 GIDA 216596026201 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 216596026202 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 216596026203 trmE is a tRNA modification GTPase; Region: trmE; cd04164 216596026204 G1 box; other site 216596026205 GTP/Mg2+ binding site [chemical binding]; other site 216596026206 Switch I region; other site 216596026207 G2 box; other site 216596026208 Switch II region; other site 216596026209 G3 box; other site 216596026210 G4 box; other site 216596026211 G5 box; other site 216596026212 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 216596026213 Pfam match to entry PF01926.7 MMR_HSR1 216596026214 transcription termination factor Rho; Provisional; Region: rho; PRK09376 216596026215 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 216596026216 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 216596026217 RNA binding site [nucleotide binding]; other site 216596026218 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 216596026219 multimer interface [polypeptide binding]; other site 216596026220 Walker A motif; other site 216596026221 ATP binding site [chemical binding]; other site 216596026222 Walker B motif; other site 216596026223 Pfam match to entry PF00006.9 ATP-synt_ab 216596026224 Pfam match to entry PF07497.1 Rho_RNA_bind 216596026225 Pfam match to entry PF07498.1 Rho_N 216596026226 Predicted membrane protein [Function unknown]; Region: COG1981 216596026227 Pfam match to entry PF03653.3 UPF0093 216596026228 5 probable transmembrane helices predicted at aa 20-37, 47-69, 90-112, 116-138 and 159-177 216596026229 Pfam match to entry PF01208.7 URO-D 216596026230 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 216596026231 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 216596026232 DNA binding residues [nucleotide binding] 216596026233 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 216596026234 P-loop; other site 216596026235 Magnesium ion binding site [ion binding]; other site 216596026236 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 216596026237 Magnesium ion binding site [ion binding]; other site 216596026238 Predicted helix-turn-helix motif with score 1205.000, SD 3.29 at aa 53-74, sequence FSSTETSKLLGVTDSYVRHLAA 216596026239 Pfam match to entry PF00991.7 ParA 216596026240 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 216596026241 ParB-like nuclease domain; Region: ParBc; pfam02195 216596026242 Pfam match to entry PF02195.5 ParBc 216596026243 Pfam match to entry PF07506.1 RepB 216596026244 replication initiation protein RepC; Provisional; Region: PRK13824 216596026245 Replication protein C N-terminal domain; Region: RP-C; pfam03428 216596026246 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 216596026247 Pfam match to entry PF03428.3 RP-C 216596026248 similarity:fasta; SWALL:Q52888 (EMBL:U22370); Rhizobium meliloti; rhizobium meliloti insertion sequence isrm2011-2 putative transposase and orfc genes, complete cds; trm2011-2; length 123 aa; 119 aa overlap; query 13-131 aa; subject 4-122 aa 216596026249 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 216596026250 putative active site [active] 216596026251 Pfam match to entry PF01850.8 PIN 216596026252 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 216596026253 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 216596026254 DNA binding site [nucleotide binding] 216596026255 dimer interface [polypeptide binding]; other site 216596026256 active site 216596026257 Int/Topo IB signature motif; other site 216596026258 Pfam match to entry PF00589.8 Phage_integrase 216596026259 PIN domain nuclease, a component of toxin-antitoxin system (PIN domain) [Signal transduction mechanisms]; Region: COG3744 216596026260 putative active site [active] 216596026261 Pfam match to entry PF01850.8 PIN 216596026262 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 216596026263 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 216596026264 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 216596026265 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 216596026266 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 216596026267 DNA binding site [nucleotide binding] 216596026268 dimer interface [polypeptide binding]; other site 216596026269 active site 216596026270 Int/Topo IB signature motif; other site 216596026271 Pfam match to entry PF00589.8 Phage_integrase 216596026272 Pfam match to entry PF02899.5 Phage_integr_N 216596026273 Protein of unknown function (DUF1403); Region: DUF1403; pfam07183 216596026274 Pfam match to entry PF07183.1 DUF1403 216596026275 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 216596026276 Pfam match to entry PF04079.5 DUF387 216596026277 TniQ; Region: TniQ; pfam06527 216596026278 Bacterial TniB protein; Region: TniB; pfam05621 216596026279 AAA domain; Region: AAA_22; pfam13401 216596026280 Pfam match to entry PF05621.1 TniB 216596026281 Winged helix-turn helix; Region: HTH_29; pfam13551 216596026282 Integrase core domain; Region: rve; pfam00665 216596026283 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 216596026284 Pfam match to entry PF00665.10 rve 216596026285 Similar to N-terminus of Klebsiella pneumoniae is903d transposase TnpA SWALL:Q8GGW8 (EMBL:AF458080) (307 aa), and to entire protein of Ruegeria sp. PR1b rc228 SWALL:Q8KVW2 (EMBL:AF416331) (110 aa); similarity:fasta; SWALL:Q8GGW8 (EMBL:AF458080); Klebsiella pneumoniae; is903d transposase; tnpA; length 307 aa; 101 aa overlap; query 13-112 aa; subject 1-101 aa; similarity:fasta; SWALL:Q8KVW2 (EMBL:AF416331); Ruegeria sp. PR1b; rc228; length 110 aa; 100 aa overlap; query 12-110 aa; subject 3-99 aa; putative transposase-related protein,pseudogene 216596026286 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 216596026287 Pfam match to entry PF06897.1 DUF1269 216596026288 Sodium Bile acid symporter family; Region: SBF; cl17470 216596026289 8 probable transmembrane helices predicted at aa 12-34, 44-66, 73-92, 102-124,131-153, 168-187, 194-216 and 253-275 216596026290 Pfam match to entry PF06897.1 SBF, E-value 4e-06 216596026291 Protein of unknown function (DUF1612); Region: DUF1612; pfam07756 216596026292 HTH DNA binding domain; Region: HTH_13; pfam11972 216596026293 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 216596026294 Restriction endonuclease; Region: Mrr_cat; pfam04471 216596026295 Methyltransferase domain; Region: Methyltransf_26; pfam13659 216596026296 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 216596026297 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cd00138 216596026298 PLD-like domain; Region: PLDc_2; pfam13091 216596026299 putative active site [active] 216596026300 catalytic site [active] 216596026301 helicase superfamily c-terminal domain; Region: HELICc; smart00490 216596026302 ATP-binding site [chemical binding]; other site 216596026303 Pfam match to entry PF00271.13 Helicase_C 216596026304 frameshift mutation pseudogene after codon 190; similarity:fasta; SWALL:Q9R6M6 (EMBL:AB016260); Agrobacterium tumefaciens; Tiorf33 protein; length 387 aa; 364 aa overlap; query 13-376 aa; subject 1-364 aa 216596026305 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 216596026306 active site 216596026307 catalytic triad [active] 216596026308 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216596026309 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 216596026310 Walker A motif; other site 216596026311 ATP binding site [chemical binding]; other site 216596026312 Walker B motif; other site 216596026313 arginine finger; other site 216596026314 Pfam match to entry PF00004.12 AAA 216596026315 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 216596026316 active site 216596026317 DNA polymerase IV; Validated; Region: PRK02406 216596026318 DNA binding site [nucleotide binding] 216596026319 Pfam match to entry PF00817.8 IMS 216596026320 Uncharacterized conserved protein [Function unknown]; Region: COG2135 216596026321 Pfam match to entry PF02586.4 DUF159 216596026322 Uncharacterized conserved protein [Function unknown]; Region: COG4544 216596026323 frameshift mutation after codon 179; similarity:fasta; SWALL:Q92ZJ7 (EMBL:AE007239); Rhizobium meliloti; hypothetical protein ra0488; sma0890; length 474 aa; 473 aa overlap; query 1-472 aa; subject 1-473 aa; conserved hypothetical protein, pseudogene 216596026324 frameshift mutation after codon 893; similarity:fasta; SWALL:DP3A_THEAQ (SWALL:Q9XDH5); Thermus aquaticus; DNA polymerase iii alpha subunit; dnaE; length 1220 aa; 1103 aa overlap; query 1-988 aa; subject 5-1087 aa; similarity:fasta; SWALL:Q92ZJ6 (EMBL:AE007239); Rhizobium meliloti; Dnae3 putative DNA polymerase iii alpha chain; dnae3; length 1087 aa; 1073 aa overlap; query 1-1072 aa; subject 1-1072 aa; DNA polymerase III alpha subunit, pseudogene 216596026325 Pfam match to entry PF02231.5 PHP_N 216596026326 Pfam match to entry PF02811.5 PHP_C 216596026327 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 216596026328 Putative transposase; Region: Y2_Tnp; pfam04986 216596026329 Pfam match to entry PF04986.3 Transposase_32 216596026330 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 216596026331 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 216596026332 Int/Topo IB signature motif; other site 216596026333 Pfam match to entry PF00589.8 Phage_integrase 216596026334 Pfam match to entry PF02899.5 Phage_integr_N 216596026335 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 216596026336 active site 216596026337 DNA binding site [nucleotide binding] 216596026338 Int/Topo IB signature motif; other site 216596026339 Pfam match to entry PF00589.8 Phage_integrase 216596026340 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 216596026341 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 216596026342 active site 216596026343 DNA binding site [nucleotide binding] 216596026344 Int/Topo IB signature motif; other site 216596026345 Pfam match to entry PF00589.8 Phage_integrase 216596026346 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 216596026347 INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190 216596026348 Int/Topo IB signature motif; other site 216596026349 Pfam match to entry PF02899.5 Phage_integr_N 216596026350 Pfam match to entry PF00589.8 Phage_integrase 216596026351 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 216596026352 DNA-binding site [nucleotide binding]; DNA binding site 216596026353 RNA-binding motif; other site 216596026354 Pfam match to entry PF00313.8 CSD 216596026355 similarity:fasta; SWALL:Q6LK89 (EMBL:CR378676); Photobacterium profundum; hypothetical protein Pp0275; pp0275; length 111 aa; 92 aa overlap; query 26-114 aa; subject 20-111 aa; conserved hypothetical protein, pseudogene 216596026356 Helix-turn-helix domain; Region: HTH_37; pfam13744 216596026357 Predicted helix-turn-helix motif with score 1048.000, SD 2.76 at aa 42-63, sequence WKNADIGAALDIPQSRVSELVR 216596026358 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 216596026359 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 216596026360 Pfam match to entry PF02812.5 GLFV_dehydrog_N 216596026361 hypothetical protein; Provisional; Region: PRK08266 216596026362 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 216596026363 PYR/PP interface [polypeptide binding]; other site 216596026364 dimer interface [polypeptide binding]; other site 216596026365 TPP binding site [chemical binding]; other site 216596026366 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 216596026367 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 216596026368 TPP-binding site [chemical binding]; other site 216596026369 Pfam match to entry PF00205.10 TPP_enzyme_M 216596026370 Pfam match to entry PF02776.6 TPP_enzyme_N 216596026371 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 216596026372 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216596026373 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596026374 homodimer interface [polypeptide binding]; other site 216596026375 catalytic residue [active] 216596026376 Pfam match to entry PF00155.8 Aminotran_1_2 216596026377 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 216596026378 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216596026379 putative DNA binding site [nucleotide binding]; other site 216596026380 putative Zn2+ binding site [ion binding]; other site 216596026381 AsnC family; Region: AsnC_trans_reg; pfam01037 216596026382 Predicted helix-turn-helix motif with score 1490.000, SD 4.26 at aa 52-73, sequence LTQTELSQVVNLSAAQCSRRLD 216596026383 Pfam match to entry PF01037.8 AsnC_trans_reg 216596026384 3 probable transmembrane helices predicted at aa 19-41, 45-67 and 79-101 216596026385 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 216596026386 Pfam match to entry PF03328.3 HpcH_HpaI 216596026387 Similar to C-terminus from codon 144 of Pseudomonas putida P-cumic aldehyde dehydrogenase CymC SWALL:O33455 (EMBL:U24215) (494 aa), and to C-terminus from codon 165 of Brucella suis aldehyde dehydrogenase family protein SWALL:Q8FUR4 (EMBL:AE014608) (468 aa); similarity:fasta; SWALL:O33455 (EMBL:U24215); Pseudomonas putida; p-cumic aldehyde dehydrogenase; cymC; length 494 aa; 326 aa overlap; query 21-344 aa; subject 164-488 aa; similarity:fasta; SWALL:Q8FUR4 (EMBL:AE014608); Brucella suis; aldehyde dehydrogenase family protein; length 468 aa; 325 aa overlap; query 21-345 aa; subject 144-467 aa; putative aldehyde dehydrogenase, pseudogene 216596026388 Pfam match to entry PF00171.9 Aldedh 216596026389 Similar to codons 163 to 226 of Clostridium acetobutylicum glutamine ABC transporter, ATP-binding protein SWALL:Q97M22 (EMBL:AE007552) (243 aa); similarity:fasta; SWALL:Q97M22 (EMBL:AE007552); Clostridium acetobutylicum; glutamine ABC transporter,ATP-binding protein; length 243 aa; 65 aa overlap; query 13-77 aa; subject 161-225 aa; putative ABC transporter ATP-binding component,pseudogene 216596026390 Pfam match to entry PF00005.11 ABC_tran 216596026391 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596026392 dimer interface [polypeptide binding]; other site 216596026393 conserved gate region; other site 216596026394 putative PBP binding loops; other site 216596026395 ABC-ATPase subunit interface; other site 216596026396 7 probable transmembrane helices predicted at aa 20-42, 73-95, 102-121,126-148, 155-177, 200-222 and 294-316 216596026397 Pfam match to entry PF00528.10 BPD_transp_1 216596026398 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 216596026399 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596026400 dimer interface [polypeptide binding]; other site 216596026401 conserved gate region; other site 216596026402 putative PBP binding loops; other site 216596026403 ABC-ATPase subunit interface; other site 216596026404 Pfam match to entry PF00528.10 BPD_transp_1 216596026405 5 probable transmembrane helices predicted at aa 28-50, 63-85, 95-117, 138-160 and 195-217 216596026406 Protein of unknown function (DUF3830); Region: DUF3830; pfam12903 216596026407 Transcriptional regulators [Transcription]; Region: GntR; COG1802 216596026408 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596026409 DNA-binding site [nucleotide binding]; DNA binding site 216596026410 FCD domain; Region: FCD; pfam07729 216596026411 Pfam match to entry PF00392.9 GntR 216596026412 Predicted helix-turn-helix motif with score 1081.000, SD 2.87 at aa 45-66, sequence MPEIQLCEHFGVSRTPLREALK 216596026413 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 216596026414 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 216596026415 active site 216596026416 Pfam match to entry PF01979.7 Amidohydro_1 216596026417 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 216596026418 Pfam match to entry PF01177.8 Asp_Glu_race 216596026419 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 216596026420 N-ethylammeline chlorohydrolase; Provisional; Region: PRK08393 216596026421 active site 216596026422 Pfam match to entry PF01979.7 Amidohydro_1 216596026423 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 216596026424 homotrimer interaction site [polypeptide binding]; other site 216596026425 putative active site [active] 216596026426 Pfam match to entry PF01042.8 Ribonuc_L-PSP 216596026427 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 216596026428 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 216596026429 Walker A/P-loop; other site 216596026430 ATP binding site [chemical binding]; other site 216596026431 Q-loop/lid; other site 216596026432 ABC transporter signature motif; other site 216596026433 Walker B; other site 216596026434 D-loop; other site 216596026435 H-loop/switch region; other site 216596026436 Pfam match to entry PF00005.11 ABC_tran 216596026437 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 216596026438 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596026439 dimer interface [polypeptide binding]; other site 216596026440 conserved gate region; other site 216596026441 putative PBP binding loops; other site 216596026442 ABC-ATPase subunit interface; other site 216596026443 Pfam match to entry PF00528.10 BPD_transp_1 216596026444 3 probable transmembrane helices predicted at aa 20-42, 63-85 and 177-199 216596026445 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 216596026446 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 216596026447 substrate binding pocket [chemical binding]; other site 216596026448 membrane-bound complex binding site; other site 216596026449 hinge residues; other site 216596026450 Pfam match to entry PF00497.8 SBP_bac_3 216596026451 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 216596026452 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 216596026453 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216596026454 Pfam match to entry PF00165.8 HTH_AraC 216596026455 Pfam match to entry PF00165.8 HTH_AraC 216596026456 Predicted helix-turn-helix motif with score 1428.000, SD 4.05 at aa 111-132, sequence LPIEEPAASVGLSRRQLERLFM 216596026457 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 216596026458 catalytic loop [active] 216596026459 iron binding site [ion binding]; other site 216596026460 Pfam match to entry PF00111.12 Fer2 216596026461 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4861 216596026462 Predicted helix-turn-helix motif with score 1142.000, SD 3.08 at aa 165-186, sequence FGVHELAERASVSPTTASQVLI 216596026463 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 216596026464 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 216596026465 Walker A/P-loop; other site 216596026466 ATP binding site [chemical binding]; other site 216596026467 Q-loop/lid; other site 216596026468 ABC transporter signature motif; other site 216596026469 Walker B; other site 216596026470 D-loop; other site 216596026471 H-loop/switch region; other site 216596026472 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 216596026473 Pfam match to entry PF00005.11 ABC_tran 216596026474 Pfam match to entry PF00571.14 CBS 216596026475 Pfam match to entry PF00571.14 CBS 216596026476 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 216596026477 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596026478 dimer interface [polypeptide binding]; other site 216596026479 conserved gate region; other site 216596026480 putative PBP binding loops; other site 216596026481 ABC-ATPase subunit interface; other site 216596026482 7 probable transmembrane helices predicted at aa 12-34, 38-60, 62-84, 89-111,132-154, 209-231 and 244-261 216596026483 Pfam match to entry PF00528.10 BPD_transp_1 216596026484 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 216596026485 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 216596026486 1 probable transmembrane helix predicted at aa 21-43 216596026487 Pfam match to entry PF04069.2 OpuAC 216596026488 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 216596026489 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216596026490 non-specific DNA binding site [nucleotide binding]; other site 216596026491 salt bridge; other site 216596026492 sequence-specific DNA binding site [nucleotide binding]; other site 216596026493 Pfam match to entry PF01381.9 HTH_3 216596026494 similarity:fasta; SWALL:Q8KW63 (EMBL:AF416331); Ruegeria sp. PR1b; rc127; length 310 aa; 227 aa overlap; query 10-230 aa; subject 46-265 aa; putative transposase family protein, pseudogene 216596026495 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 216596026496 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 216596026497 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596026498 catalytic residue [active] 216596026499 Pfam match to entry PF00291.10 PALP 216596026500 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 216596026501 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; cl17722 216596026502 Similar to codons 798 to 1055 (with a frameshift) of Agrobacterium tumefaciens str. C58 DNA polymerase iii,alpha chain dnaE SWALL:Q8U642 (EMBL:AE009428) (1087 aa); similarity:fasta; SWALL:Q8U642 (EMBL:AE009428); Agrobacterium tumefaciens str. C58; DNA polymerase iii,alpha chain; dnaE; length 1087 aa; 252 aa overlap; query 1-251 aa; subject 797-1048 aa 216596026503 similarity:fasta; SWALL:Q92WA5 (EMBL:AL603643); Rhizobium meliloti; putative transcriptional regulator transcription regulator protein; smb20457; length 382 aa; 137 aa overlap; query 4-134 aa; subject 38-168 aa; putative transcriptional regulatory protein,pseudogene 216596026504 N-terminus is similar to the N-terminus of Rhizobium sp. hypothetical 14.4 kDa protein y4sn SWALL:Y4SN_RHISN (SWALL:P50358) (125 aa); similarity:fasta; SWALL:Y4SN_RHISN (SWALL:P50358); Rhizobium sp.; hypothetical 14.4 kDa protein y4sn; length 125 aa; 59 aa overlap; query 1-59 aa; subject 1-59 aa; conserved hypothetical protein, pseudogene 216596026505 N-terminus is similar to the N-terminus of Rhizobium loti transposase SWALL:Q989N0 (EMBL:AP003009) (222 aa); similarity:fasta; SWALL:Q989N0 (EMBL:AP003009); Rhizobium loti; transposase; length 222 aa; 76 aa overlap; query 1-76 aa; subject 1-76 aa; putative transposase, pseudogene 216596026506 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 216596026507 Transposase; Region: HTH_Tnp_1; cl17663 216596026508 Predicted helix-turn-helix motif with score 1250.000, SD 3.44 at aa 26-47, sequence QTLVELSQQFDVHANQIKQWKD 216596026509 similarity:fasta; SWALL:Q57113 (EMBL:M96392); Erwinia amylovora; orf b; length 285 aa; 272 aa overlap; query 1-256 aa; subject 6-277 aa; similarity:fasta; SWALL:Q92LG0 (EMBL:AL591792); Rhizobium meliloti; putative transposase protein; smc03248; length 276 aa; 276 aa overlap; query 1-271 aa; subject 1-276 aa; putative transposase protein, pseudogene 216596026510 Pfam match to entry PF00665.10 rve 216596026511 bacteriocin maturation radical SAM protein 1; Region: rSAM_ocin_1; TIGR03975 216596026512 Pfam match to entry PF04055.5 Radical_SAM 216596026513 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 216596026514 FeS/SAM binding site; other site 216596026515 similarity:fasta; SWALL:NIFH_RHILT (SWALL:P00461); Rhizobium leguminosarum; nitrogenase iron protein; nifH; length 297 aa; 32 aa overlap; query 1-32 aa; subject 1-32 aa; similarity:fasta; SWALL:Q53257 (EMBL:X02479); Rhizobium leguminosarum; r.trifolii; length 73 aa; 43 aa overlap; query 1-43 aa; subject 1-38 aa; putative nitrogenase iron protein, pseudogene 216596026516 Pfam match to entry PF00142.7 Fer4_NifH 216596026517 similarity:fasta; SWALL:Q8XSC1 (EMBL:AL646079); Ralstonia solanacearum; isrso16-transposase orfa protein; tisrso16A; length 88 aa; 61 aa overlap; query 2-60 aa; subject 21-81 aa; putative transposase, pseudogene 216596026518 similarity:fasta; SWALL:Q986Y0 (EMBL:AP003011); Rhizobium loti; acetolactate synthase large subunit; length 548 aa; 574 aa overlap; query 13-585 aa; subject 3-547 aa; putative acetolactate synthase, pseudogene 216596026519 Pfam match to entry PF02776.6 TPP_enzyme_N 216596026520 Pfam match to entry PF00205.10 TPP_enzyme_M 216596026521 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 216596026522 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 216596026523 putative active site [active] 216596026524 metal binding site [ion binding]; metal-binding site 216596026525 Pfam match to entry PF00465.7 Fe-ADH 216596026526 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E); Region: PHA_synth_III_E; cl09914 216596026527 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 216596026528 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 216596026529 Pfam match to entry PF00561.8 Abhydrolase_1 216596026530 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 216596026531 MerR family regulatory protein; Region: MerR; pfam00376 216596026532 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 216596026533 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 216596026534 Predicted helix-turn-helix motif with score 1383.000, SD 3.90 at aa 46-67, sequence FSLGEVAEILGVSGSYLRQLSI 216596026535 Pfam match to entry PF00376.9 MerR 216596026536 plasmid partitioning protein; Provisional; Region: PRK13832 216596026537 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 216596026538 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216596026539 motif II; other site 216596026540 Pfam match to entry PF00702.10 Hydrolase 216596026541 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 216596026542 similarity:fasta; SWALL:Q89N19 (EMBL:AP005949); Bradyrhizobium japonicum USDA 110; blr4023 protein; length 554 aa; 538 aa overlap; query 2-529 aa; subject 8-542 aa; putative acetolactate synthase, pseudogene 216596026543 Pfam match to entry PF02776.6 TPP_enzyme_N 216596026544 Pfam match to entry PF00205.10 TPP_enzyme_M 216596026545 submitted without /pseudo; similarity:fasta; SWALL:EUTG_ECOLI (SWALL:P76553); Escherichia coli; ethanolamine utilization protein EutG; length 395 aa; 381 aa overlap; query 4-383 aa; subject 23-394 aa; similarity:fasta; SWALL:Q8UKH1 (EMBL:AE008938); Agrobacterium tumefaciens str. C58; alcohol dehydrogenase; attL; length 386 aa; 383 aa overlap; query 5-384 aa; subject 8-386 aa; frameshift mutation after codon 241 216596026546 Pfam match to entry PF00465.7 Fe-ADH 216596026547 Pfam match to entry PF00465.7 Fe-ADH 216596026548 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 216596026549 Coenzyme A transferase; Region: CoA_trans; smart00882 216596026550 Coenzyme A transferase; Region: CoA_trans; cl17247 216596026551 Pfam match to entry PF01144.9 CoA_trans 216596026552 Phasin protein; Region: Phasin_2; pfam09361 216596026553 acetyl-CoA synthetase; Provisional; Region: PRK00174 216596026554 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 216596026555 acyl-activating enzyme (AAE) consensus motif; other site 216596026556 AMP binding site [chemical binding]; other site 216596026557 active site 216596026558 CoA binding site [chemical binding]; other site 216596026559 Pfam match to entry PF00501.11 AMP-binding 216596026560 adenylate kinase; Reviewed; Region: adk; PRK00279 216596026561 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 216596026562 AMP-binding site [chemical binding]; other site 216596026563 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 216596026564 Pfam match to entry PF00406.10 ADK 216596026565 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 216596026566 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 216596026567 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 216596026568 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 216596026569 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 216596026570 Pfam match to entry PF03050.4 Transposase_25 216596026571 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 216596026572 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 216596026573 Pfam match to entry PF05717.2 Transposase_34 216596026574 Transposase; Region: HTH_Tnp_1; pfam01527 216596026575 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 216596026576 Pfam match to entry PF01527.7 Transposase_8 216596026577 Predicted helix-turn-helix motif with score 1195.000, SD 3.26 at aa 49-70, sequence ASVSKLAREHGVNANLVWKWIR 216596026578 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 216596026579 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 216596026580 Walker A/P-loop; other site 216596026581 ATP binding site [chemical binding]; other site 216596026582 Q-loop/lid; other site 216596026583 ABC transporter signature motif; other site 216596026584 Walker B; other site 216596026585 D-loop; other site 216596026586 H-loop/switch region; other site 216596026587 Pfam match to entry PF00005.11 ABC_tran 216596026588 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 216596026589 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 216596026590 Walker A/P-loop; other site 216596026591 ATP binding site [chemical binding]; other site 216596026592 Q-loop/lid; other site 216596026593 ABC transporter signature motif; other site 216596026594 Walker B; other site 216596026595 D-loop; other site 216596026596 H-loop/switch region; other site 216596026597 Pfam match to entry PF00005.11 ABC_tran 216596026598 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 216596026599 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596026600 TM-ABC transporter signature motif; other site 216596026601 9 probable transmembrane helices predicted at aa 7-26, 31-48, 55-77, 82-104,111-128, 155-177, 208-230, 245-267 and 284-306 216596026602 Pfam match to entry PF02653.5 BPD_transp_2 216596026603 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596026604 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 216596026605 TM-ABC transporter signature motif; other site 216596026606 8 probable transmembrane helices predicted at aa 15-37, 50-72, 77-99, 112-134,157-179, 210-232, 247-269 and 274-296 216596026607 Pfam match to entry PF02653.5 BPD_transp_2 216596026608 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 216596026609 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_Arsenic_SBP_like; cd06330 216596026610 putative ligand binding site [chemical binding]; other site 216596026611 Pfam match to entry PF01094.13 ANF_receptor 216596026612 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 216596026613 Transcriptional regulator [Transcription]; Region: IclR; COG1414 216596026614 Bacterial transcriptional regulator; Region: IclR; pfam01614 216596026615 Pfam match to entry PF01614.6 IclR 216596026616 succinic semialdehyde dehydrogenase; Region: PLN02278 216596026617 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 216596026618 tetramerization interface [polypeptide binding]; other site 216596026619 NAD(P) binding site [chemical binding]; other site 216596026620 catalytic residues [active] 216596026621 Pfam match to entry PF00171.9 Aldedh 216596026622 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 216596026623 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 216596026624 putative active site [active] 216596026625 metal binding site [ion binding]; metal-binding site 216596026626 Pfam match to entry PF00465.7 Fe-ADH 216596026627 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 216596026628 Pfam match to entry PF00753.13 Lactamase_B 216596026629 homoserine O-acetyltransferase; Provisional; Region: PRK06765 216596026630 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 216596026631 Pfam match to entry PF00561.8 Abhydrolase_1 216596026632 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 216596026633 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 216596026634 DNA binding residues [nucleotide binding] 216596026635 dimer interface [polypeptide binding]; other site 216596026636 Predicted helix-turn-helix motif with score 1843.000, SD 5.46 at aa 35-56, sequence YTIAEAARIAGSTTSTLRLWEK 216596026637 Pfam match to entry PF00376.9 MerR 216596026638 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 216596026639 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 216596026640 catalytic residues [active] 216596026641 catalytic nucleophile [active] 216596026642 Recombinase; Region: Recombinase; pfam07508 216596026643 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 216596026644 Pfam match to entry PF07508.1 Recombinase 216596026645 Codons 538 to 215 are similar to codons 538 to 722 of Agrobacterium rhizogenes Riorf93 protein SWALL:Q9F5F7 (EMBL:AP002086) (1693 aa). Frameshift at codon 172.; similarity:fasta; SWALL:Q9F5F7 (EMBL:AP002086); Agrobacterium rhizogenes; Riorf93 protein; length 1693 aa; 183 aa overlap; query 32-214 aa; subject 537-719 aa 216596026646 similarity:fasta; SWALL:Q9R6L0 (EMBL:AB016260); Agrobacterium tumefaciens; Tiorf49 protein; length 637 aa; 572 aa overlap; query 10-567 aa; subject 26-591 aa; possible frameshift after codon 173, stop codon at 256, and frameshift after 367; putative parB-like protein, pseudogene 216596026647 Pfam match to entry PF02195.5 ParBc 216596026648 N-terminus is similar to the N-terminus of Pseudomonas putida acetolactate synthase, catabolic,putative SWALL:Q877U6 (EMBL:AE016778) (547 aa); similarity:fasta; SWALL:Q877U6 (EMBL:AE016778); Pseudomonas putida; acetolactate synthase, catabolic,putative; length 547 aa; 68 aa overlap; query 10-72 aa; subject 3-70 aa; putative acetolactate synthase, pseudogene 216596026649 acyl carrier protein; Provisional; Region: PRK07081 216596026650 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216596026651 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216596026652 active site 216596026653 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216596026654 active site 216596026655 Pfam match to entry PF02771.6 Acyl-CoA_dh_N 216596026656 ThiC-associated domain; Region: ThiC-associated; pfam13667 216596026657 ThiC family; Region: ThiC; cl08031 216596026658 Pfam match to entry PF01964.7 ThiC 216596026659 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216596026660 non-specific DNA binding site [nucleotide binding]; other site 216596026661 salt bridge; other site 216596026662 sequence-specific DNA binding site [nucleotide binding]; other site 216596026663 Pfam match to entry PF01381.9 HTH_3 216596026664 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 216596026665 Putative transposase; Region: Y2_Tnp; pfam04986 216596026666 Pfam match to entry PF04986.3 Transposase_32 216596026667 integron integrase; Region: integrase_gron; TIGR02249 216596026668 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 216596026669 Int/Topo IB signature motif; other site 216596026670 Pfam match to entry PF00589.8 Phage_integrase 216596026671 Pfam match to entry PF02899.5 Phage_integr_N 216596026672 2 probable transmembrane helices predicted at aa 52-74 and 84-106 216596026673 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 216596026674 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 216596026675 Pfam match to entry PF00037.11 Fer4 216596026676 Pfam match to entry PF00037.11 Fer4 216596026677 Similar to codons 21 to 95 of Rhizobium sp. NifX protein SWALL:NIFX_RHISN (SWALL:P55675) (160 aa), and to codons 25 to 100 of Acetobacter diazotrophicus NifX SWALL:Q9FA20 (EMBL:AF030414) (164 aa); similarity:fasta; SWALL:NIFX_RHISN (SWALL:P55675); Rhizobium sp.; NifX protein; length 160 aa; 75 aa overlap; query 2-71 aa; subject 20-94 aa; similarity:fasta; SWALL:Q9FA20 (EMBL:AF030414); Acetobacter diazotrophicus; NifX; length 164 aa; 73 aa overlap; query 5-72 aa; subject 27-99 aa; putative nitrogen fixation NifX protein,pseudogene 216596026678 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 216596026679 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 216596026680 Pfam match to entry PF00148.8 Oxidored_nitro 216596026681 nitrogenase molybdenum-cofactor biosynthesis protein NifE; Provisional; Region: PRK14478 216596026682 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 216596026683 Pfam match to entry PF00148.8 Oxidored_nitro 216596026684 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 216596026685 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 216596026686 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 216596026687 MoFe protein beta/alpha subunit interactions; other site 216596026688 Beta subunit P cluster binding residues; other site 216596026689 MoFe protein beta subunit/Fe protein contacts; other site 216596026690 MoFe protein dimer/ dimer interactions; other site 216596026691 Pfam match to entry PF00148.8 Oxidored_nitro 216596026692 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 216596026693 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 216596026694 MoFe protein alpha/beta subunit interactions; other site 216596026695 Alpha subunit P cluster binding residues; other site 216596026696 FeMoco binding residues [chemical binding]; other site 216596026697 MoFe protein alpha subunit/Fe protein contacts; other site 216596026698 MoFe protein dimer/ dimer interactions; other site 216596026699 Pfam match to entry PF00148.8 Oxidored_nitro 216596026700 nitrogenase reductase; Reviewed; Region: nifH; PRK13234 216596026701 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 216596026702 Nucleotide-binding sites [chemical binding]; other site 216596026703 Walker A motif; other site 216596026704 Switch I region of nucleotide binding site; other site 216596026705 Fe4S4 binding sites [ion binding]; other site 216596026706 Switch II region of nucleotide binding site; other site 216596026707 Pfam match to entry PF00142.7 Fer4_NifH 216596026708 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 216596026709 Ligand Binding Site [chemical binding]; other site 216596026710 Autoinducer synthetase; Region: Autoind_synth; cl17404 216596026711 Pfam match to entry PF00765.7 Autoind_synth 216596026712 integron integrase; Region: integrase_gron; TIGR02249 216596026713 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 216596026714 Int/Topo IB signature motif; other site 216596026715 Pfam match to entry PF02899.5 Phage_integr_N 216596026716 Pfam match to entry PF00589.8 Phage_integrase 216596026717 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 216596026718 Putative transposase; Region: Y2_Tnp; pfam04986 216596026719 Pfam match to entry PF04986.3 Transposase_32 216596026720 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 216596026721 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 216596026722 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 216596026723 Pfam match to entry PF01609.9 Transposase_11 216596026724 1 probable transmembrane helix predicted at aa 57-74 216596026725 Phage Tail Collar Domain; Region: Collar; pfam07484 216596026726 Pfam match to entry PF07484.1 Collar 216596026727 1 probable transmembrane helix predicted at aa 7-26 216596026728 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 216596026729 Autoinducer binding domain; Region: Autoind_bind; pfam03472 216596026730 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216596026731 DNA binding residues [nucleotide binding] 216596026732 dimerization interface [polypeptide binding]; other site 216596026733 Pfam match to entry PF00196.8 GerE 216596026734 Predicted helix-turn-helix motif with score 1198.000, SD 3.27 at aa 201-222, sequence KTAIEIATILGRSHRTIQNVIL 216596026735 Pfam match to entry PF03472.4 Autoind_bind 216596026736 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 216596026737 RTX N-terminal domain; Region: RTX; pfam02382 216596026738 Pfam match to entry PF00353.8 HemolysinCabind 216596026739 Pfam match to entry PF00353.8 HemolysinCabind 216596026740 Pfam match to entry PF00353.8 HemolysinCabind 216596026741 Pfam match to entry PF00353.8 HemolysinCabind 216596026742 Pfam match to entry PF00353.8 HemolysinCabind 216596026743 Codons 130 to C-terminus are similar to codons 120 to 170 of Rhizobium sp. putative insertion sequence ATP-binding protein y4pl SWALL:Y4PL_RHISN (SWALL:P55617) (245 aa); similarity:fasta; SWALL:Y4PL_RHISN (SWALL:P55617); Rhizobium sp.; putative insertion sequence ATP-binding protein y4pl; length 245 aa; 47 aa overlap; query 131-177 aa; subject 122-168 aa; putative insertion sequence, pseudogene 216596026744 Pfam match to entry PF01695.6 IstB 216596026745 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 216596026746 Pfam match to entry PF02321.6 OEP 216596026747 Pfam match to entry PF02321.6 OEP 216596026748 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 216596026749 putative active site [active] 216596026750 putative catalytic site [active] 216596026751 Pfam match to entry PF01575.6 MaoC_dehydratas 216596026752 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 216596026753 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 216596026754 glutaminase active site [active] 216596026755 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 216596026756 dimer interface [polypeptide binding]; other site 216596026757 active site 216596026758 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 216596026759 dimer interface [polypeptide binding]; other site 216596026760 active site 216596026761 Pfam match to entry PF01380.9 SIS 216596026762 Pfam match to entry PF01380.9 SIS 216596026763 Pfam match to entry PF00310.9 GATase_2 216596026764 atcnnnnnnnnngatnnnnnnnnnnnnnnnnatcnnnnnnnnnaat 216596026765 maltose O-acetyltransferase; Provisional; Region: PRK10092 216596026766 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 216596026767 active site 216596026768 substrate binding site [chemical binding]; other site 216596026769 trimer interface [polypeptide binding]; other site 216596026770 CoA binding site [chemical binding]; other site 216596026771 Pfam match to entry PF00132.9 Hexapep 216596026772 Pfam match to entry PF00132.9 Hexapep 216596026773 Pfam match to entry PF00132.9 Hexapep 216596026774 Pfam match to entry PF00132.9 Hexapep 216596026775 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 216596026776 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 216596026777 dimer interface [polypeptide binding]; other site 216596026778 active site 216596026779 Pfam match to entry PF02801.7 Ketoacyl-synt_C 216596026780 Pfam match to entry PF00109.11 ketoacyl-synt 216596026781 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 216596026782 Pfam match to entry PF00550.9 PP-binding 216596026783 atcnnnnnnnnngatnnnnnnnnnnnnnnnnatcnnnnnnnnnaat 216596026784 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596026785 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596026786 The C-terminal substsrate binding domain of NodD family of LysR-type transcriptional regulators that regulates the expression of nodulation (nod) genes; contains the type 2 periplasmic binding fold; Region: PBP2_NodD; cd08462 216596026787 putative substrate binding pocket [chemical binding]; other site 216596026788 putative dimerization interface [polypeptide binding]; other site 216596026789 Pfam match to entry PF03466.5 LysR_substrate 216596026790 Pfam match to entry PF00126.10 HTH_1 216596026791 Predicted helix-turn-helix motif with score 1317.000, SD 3.67 at aa 39-60, sequence RKLTAAARSINLSQPAMSAAIS 216596026792 atcnnnnnnnnngatnnnnnnnnnnnnnnnnatcnnnnnnnnnaat 216596026793 Nodulation protein A (NodA); Region: NodA; pfam02474 216596026794 Pfam match to entry PF02474.5 NodA 216596026795 chitooligosaccharide deacetylase NodB; Region: nodulat_NodB; TIGR04243 216596026796 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 216596026797 Pfam match to entry PF01522.9 Polysacc_deac_1 216596026798 chitooligosaccharide synthase NodC; Region: nodulat_NodC; TIGR04242 216596026799 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 216596026800 DXD motif; other site 216596026801 4 probable transmembrane helices predicted at aa 4-22, 307-329, 333-355 and 362-384 216596026802 Pfam match to entry PF00535.10 Glycos_transf_2 216596026803 Pfam match to entry PF03142.4 Chitin_synth_2 216596026804 nodulation factor exporter subunit NodI; Provisional; Region: PRK13536 216596026805 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 216596026806 Walker A/P-loop; other site 216596026807 ATP binding site [chemical binding]; other site 216596026808 Q-loop/lid; other site 216596026809 ABC transporter signature motif; other site 216596026810 Walker B; other site 216596026811 D-loop; other site 216596026812 H-loop/switch region; other site 216596026813 Pfam match to entry PF00005.11 ABC_tran 216596026814 ABC-2 type transporter; Region: ABC2_membrane; cl17235 216596026815 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 216596026816 6 probable transmembrane helices predicted at aa 27-49, 64-86, 122-141,145-167, 174-196 and 231-253 216596026817 Pfam match to entry PF01061.8 ABC2_membrane 216596026818 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 216596026819 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 216596026820 Pfam match to entry PF01609.9 Transposase_11 216596026821 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 216596026822 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 216596026823 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 216596026824 FeS/SAM binding site; other site 216596026825 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 216596026826 Pfam match to entry PF02579.7 Nitro_FeMo-Co 216596026827 Pfam match to entry PF04055.5 Radical_SAM 216596026828 Nif-specific regulatory protein; Region: nifA; TIGR01817 216596026829 GAF domain; Region: GAF; cl17456 216596026830 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216596026831 Walker A motif; other site 216596026832 ATP binding site [chemical binding]; other site 216596026833 Walker B motif; other site 216596026834 arginine finger; other site 216596026835 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 216596026836 Pfam match to entry PF02954.7 HTH_8 216596026837 Predicted helix-turn-helix motif with score 1705.000, SD 4.99 at aa 497-518, sequence WVQAKAARILGKTPRQVGYALR 216596026838 Pfam match to entry PF00158.13 Sigma54_activat 216596026839 Pfam match to entry PF01590.11 GAF 216596026840 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 216596026841 oxidoreductase; Provisional; Region: PRK10015 216596026842 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 216596026843 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 216596026844 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 216596026845 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 216596026846 Pfam match to entry PF00766.8 ETF_alpha 216596026847 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 216596026848 Ligand binding site [chemical binding]; other site 216596026849 Electron transfer flavoprotein domain; Region: ETF; pfam01012 216596026850 Pfam match to entry PF01012.9 ETF_beta 216596026851 similarity:fasta; SWALL:Q9S4I4 (EMBL:AF144038); Rhizobium leguminosarum; putative transposase; tnP; length 277 aa; 179 aa overlap; query 1-173 aa; subject 1-179 aa; putative frameshift after codon 130 and after codon 215; putative transposase, pseudogene 216596026852 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 216596026853 Low-spin heme binding site [chemical binding]; other site 216596026854 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 216596026855 Putative water exit pathway; other site 216596026856 Binuclear center (active site) [active] 216596026857 Putative proton exit pathway; other site 216596026858 14 probable transmembrane helices predicted at aa 7-24, 29-51, 74-96, 116-138,150-172, 185-207, 220-242, 262-284, 293-315, 330-352,365-387, 402-424, 441-463 and 493-515 216596026859 Pfam match to entry PF00115.8 COX1 216596026860 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 216596026861 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 216596026862 Pfam match to entry PF02433.5 FixO 216596026863 1 probable transmembrane helix predicted at aa 17-39 216596026864 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 216596026865 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 216596026866 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 216596026867 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 216596026868 1 probable transmembrane helix predicted at aa 32-54 216596026869 Pfam match to entry PF00034.8 Cytochrom_C 216596026870 Pfam match to entry PF00034.8 Cytochrom_C 216596026871 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 216596026872 4Fe-4S binding domain; Region: Fer4_5; pfam12801 216596026873 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 216596026874 5 probable transmembrane helices predicted at aa 50-68, 100-122, 174-191,206-228 and 382-401 216596026875 Pfam match to entry PF00037.11 Fer4 216596026876 Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456 216596026877 FixH; Region: FixH; pfam05751 216596026878 Pfam match to entry PF05751.1 FixH 216596026879 1 probable transmembrane helix predicted at aa 13-35 216596026880 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 216596026881 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 216596026882 metal-binding site [ion binding] 216596026883 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 216596026884 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 216596026885 Pfam match to entry PF00403.12 HMA 216596026886 6 probable transmembrane helices predicted at aa 122-144, 154-176, 368-390,400-422, 695-714 and 718-740 216596026887 Pfam match to entry PF00122.7 E1-E2_ATPase 216596026888 Pfam match to entry PF00702.10 Hydrolase 216596026889 cytochrome oxidase maturation protein, cbb3-type; Region: ccoS; TIGR00847 216596026890 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 216596026891 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 216596026892 ligand binding site [chemical binding]; other site 216596026893 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 216596026894 Pfam match to entry PF00027.13 cNMP_binding 216596026895 Predicted helix-turn-helix motif with score 1488.000, SD 4.25 at aa 176-197, sequence YRKRILAGKLGLAPEALSRAFA 216596026896 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596026897 Transcriptional regulators [Transcription]; Region: GntR; COG1802 216596026898 DNA-binding site [nucleotide binding]; DNA binding site 216596026899 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596026900 Transcriptional regulators [Transcription]; Region: GntR; COG1802 216596026901 DNA-binding site [nucleotide binding]; DNA binding site 216596026902 Pfam match to entry PF00392 GntR 216596026903 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 216596026904 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 216596026905 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 216596026906 Pfam match to entry PF03050.4 Transposase_25 216596026907 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596026908 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596026909 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 216596026910 dimerization interface [polypeptide binding]; other site 216596026911 substrate binding pocket [chemical binding]; other site 216596026912 Pfam match to entry PF00126.10 HTH_1 216596026913 Predicted helix-turn-helix motif with score 1057.000, SD 2.79 at aa 16-37, sequence LHFGRAAAKVRIAQPALSNHVQ 216596026914 Pfam match to entry PF03466.5 LysR_substrate 216596026915 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 216596026916 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 216596026917 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 216596026918 Pfam match to entry PF05406.2 WGR 216596026919 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 216596026920 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 216596026921 Walker A motif; other site 216596026922 ATP binding site [chemical binding]; other site 216596026923 Walker B motif; other site 216596026924 Pfam match to entry PF02534.4 TraG 216596026925 3 probable transmembrane helices predicted at aa 22-39, 44-66 and 73-95 216596026926 Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768 216596026927 MobA/MobL family; Region: MobA_MobL; pfam03389 216596026928 AAA domain; Region: AAA_30; pfam13604 216596026929 Family description; Region: UvrD_C_2; pfam13538 216596026930 Pfam match to entry PF03389.3 MobA_MobL 216596026931 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 216596026932 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 216596026933 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 216596026934 Pfam match to entry PF02604.5 PhdYeFM 216596026935 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 216596026936 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 216596026937 Pfam match to entry PF00296.10 Bac_luciferase 216596026938 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 216596026939 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 216596026940 active site 216596026941 non-prolyl cis peptide bond; other site 216596026942 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 216596026943 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 216596026944 metal binding site [ion binding]; metal-binding site 216596026945 putative dimer interface [polypeptide binding]; other site 216596026946 Pfam match to entry PF01546.13 Peptidase_M20 216596026947 Pfam match to entry PF07687.1 M20_dimer 216596026948 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216596026949 Coenzyme A binding pocket [chemical binding]; other site 216596026950 Pfam match to entry PF00583.9 Acetyltransf_1 216596026951 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596026952 dimer interface [polypeptide binding]; other site 216596026953 conserved gate region; other site 216596026954 putative PBP binding loops; other site 216596026955 ABC-ATPase subunit interface; other site 216596026956 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 216596026957 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 216596026958 Walker A/P-loop; other site 216596026959 ATP binding site [chemical binding]; other site 216596026960 Q-loop/lid; other site 216596026961 ABC transporter signature motif; other site 216596026962 Walker B; other site 216596026963 D-loop; other site 216596026964 H-loop/switch region; other site 216596026965 5 probable transmembrane helices predicted at aa 33-55, 82-104, 117-139,159-181 and 262-284 216596026966 Pfam match to entry PF00528.10 BPD_transp_1 216596026967 Pfam match to entry PF00005.11 ABC_tran 216596026968 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 216596026969 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 216596026970 substrate binding pocket [chemical binding]; other site 216596026971 membrane-bound complex binding site; other site 216596026972 hinge residues; other site 216596026973 Pfam match to entry PF00497.8 SBP_bac_3 216596026974 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 216596026975 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 216596026976 substrate binding pocket [chemical binding]; other site 216596026977 membrane-bound complex binding site; other site 216596026978 hinge residues; other site 216596026979 Pfam match to entry PF00497.8 SBP_bac_3 216596026980 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 216596026981 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 216596026982 Pfam match to entry PF00296.10 Bac_luciferase 216596026983 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 216596026984 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 216596026985 putative catalytic residue [active] 216596026986 Pfam match to entry PF01323.9 DSBA 216596026987 FMN reductase, MsuE subfamily; Region: FMN_reduc_MsuE; TIGR03566 216596026988 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 216596026989 Pfam match to entry PF03358.3 FMN_red 216596026990 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 216596026991 Pfam match to entry PF06821.1 DUF1234 216596026992 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 216596026993 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 216596026994 putative active site pocket [active] 216596026995 dimerization interface [polypeptide binding]; other site 216596026996 putative catalytic residue [active] 216596026997 Pfam match to entry PF04752.2 ChaC 216596026998 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 216596026999 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596027000 dimer interface [polypeptide binding]; other site 216596027001 conserved gate region; other site 216596027002 putative PBP binding loops; other site 216596027003 ABC-ATPase subunit interface; other site 216596027004 Pfam match to entry PF00528.10 BPD_transp_1 216596027005 6 probable transmembrane helices predicted at aa 35-57, 92-114, 129-151,158-180, 209-231 and 251-273 216596027006 ABC-type taurine transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG4525 216596027007 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 216596027008 Walker A/P-loop; other site 216596027009 ATP binding site [chemical binding]; other site 216596027010 Q-loop/lid; other site 216596027011 ABC transporter signature motif; other site 216596027012 Walker B; other site 216596027013 D-loop; other site 216596027014 H-loop/switch region; other site 216596027015 Pfam match to entry PF00005.11 ABC_tran 216596027016 taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729 216596027017 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 216596027018 substrate binding pocket [chemical binding]; other site 216596027019 membrane-bound complex binding site; other site 216596027020 hinge residues; other site 216596027021 Pfam match to entry PF06642.1 TauA_C 216596027022 Pfam match to entry PF04069.2 OpuAC 216596027023 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 216596027024 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 216596027025 Transcriptional regulators [Transcription]; Region: FadR; COG2186 216596027026 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596027027 DNA-binding site [nucleotide binding]; DNA binding site 216596027028 FCD domain; Region: FCD; pfam07729 216596027029 Pfam match to entry PF00392.9 GntR 216596027030 Predicted helix-turn-helix motif with score 1076.000, SD 2.85 at aa 41-62, sequence LVERDLCAQLGVSRTVVREVLR 216596027031 Amino acid synthesis; Region: AA_synth; pfam06684 216596027032 Pfam match to entry PF06684.1 DUF1185 216596027033 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 216596027034 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216596027035 Pfam match to entry PF00561.8 Abhydrolase_1 216596027036 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 216596027037 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 216596027038 Pfam match to entry PF01613.6 Flavin_Reduct 216596027039 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 216596027040 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 216596027041 Pfam match to entry PF00296.10 Bac_luciferase 216596027042 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 216596027043 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 216596027044 NAD(P) binding site [chemical binding]; other site 216596027045 catalytic residues [active] 216596027046 Pfam match to entry PF00171.9 Aldedh 216596027047 NIPSNAP; Region: NIPSNAP; pfam07978 216596027048 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 216596027049 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 216596027050 Pfam match to entry PF01547.11 SBP_bac_1 216596027051 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596027052 dimer interface [polypeptide binding]; other site 216596027053 conserved gate region; other site 216596027054 putative PBP binding loops; other site 216596027055 ABC-ATPase subunit interface; other site 216596027056 6 probable transmembrane helices predicted at aa 24-46, 77-99, 109-131,152-174, 214-236 and 257-279 216596027057 Pfam match to entry PF00528.10 BPD_transp_1 216596027058 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 216596027059 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596027060 dimer interface [polypeptide binding]; other site 216596027061 conserved gate region; other site 216596027062 putative PBP binding loops; other site 216596027063 ABC-ATPase subunit interface; other site 216596027064 6 probable transmembrane helices predicted at aa 13-35, 73-95, 107-129,134-156, 193-215 and 238-260 216596027065 Pfam match to entry PF00528.10 BPD_transp_1 216596027066 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 216596027067 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216596027068 Walker A/P-loop; other site 216596027069 ATP binding site [chemical binding]; other site 216596027070 Q-loop/lid; other site 216596027071 ABC transporter signature motif; other site 216596027072 Walker B; other site 216596027073 D-loop; other site 216596027074 H-loop/switch region; other site 216596027075 TOBE domain; Region: TOBE_2; pfam08402 216596027076 Pfam match to entry PF00005.11 ABC_tran 216596027077 Pfam match to entry PF03459.4 TOBE 216596027078 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 216596027079 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 216596027080 tetramerization interface [polypeptide binding]; other site 216596027081 NAD(P) binding site [chemical binding]; other site 216596027082 catalytic residues [active] 216596027083 Pfam match to entry PF00171.9 Aldedh 216596027084 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 216596027085 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 216596027086 putative active site [active] 216596027087 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 216596027088 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 216596027089 Walker A/P-loop; other site 216596027090 ATP binding site [chemical binding]; other site 216596027091 Q-loop/lid; other site 216596027092 ABC transporter signature motif; other site 216596027093 Walker B; other site 216596027094 D-loop; other site 216596027095 H-loop/switch region; other site 216596027096 TOBE domain; Region: TOBE_2; pfam08402 216596027097 Pfam match to entry PF00005.11 ABC_tran 216596027098 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216596027099 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596027100 dimer interface [polypeptide binding]; other site 216596027101 conserved gate region; other site 216596027102 putative PBP binding loops; other site 216596027103 ABC-ATPase subunit interface; other site 216596027104 Pfam match to entry PF00528.10 BPD_transp_1 216596027105 6 probable transmembrane helices predicted at aa 7-29, 71-93, 106-128, 138-160,181-203 and 238-260 216596027106 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596027107 dimer interface [polypeptide binding]; other site 216596027108 conserved gate region; other site 216596027109 putative PBP binding loops; other site 216596027110 ABC-ATPase subunit interface; other site 216596027111 Pfam match to entry PF00528.10 BPD_transp_1 216596027112 6 probable transmembrane helices predicted at aa 13-35, 73-95, 107-129,162-184, 207-229 and 263-285 216596027113 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 216596027114 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 216596027115 Pfam match to entry PF01547.11 SBP_bac_1 216596027116 1 probable transmembrane helix predicted at aa 7-26 216596027117 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 216596027118 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 216596027119 Pfam match to entry PF05592.1 Bac_rhamnosid 216596027120 Predicted helix-turn-helix motif with score 993.000, SD 2.57 at aa 364-385, sequence QVFAATACWLSDSQSFLRKYLR 216596027121 Transcriptional regulators [Transcription]; Region: PurR; COG1609 216596027122 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216596027123 DNA binding site [nucleotide binding] 216596027124 domain linker motif; other site 216596027125 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 216596027126 dimerization interface [polypeptide binding]; other site 216596027127 ligand binding site [chemical binding]; other site 216596027128 Predicted helix-turn-helix motif with score 1340.000, SD 3.75 at aa 15-36, sequence VTIRTVATHAGVSVAAVSKVMR 216596027129 Pfam match to entry PF00532.8 Peripla_BP_1 216596027130 Transcriptional regulators [Transcription]; Region: PurR; COG1609 216596027131 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216596027132 DNA binding site [nucleotide binding] 216596027133 domain linker motif; other site 216596027134 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 216596027135 ligand binding site [chemical binding]; other site 216596027136 dimerization interface [polypeptide binding]; other site 216596027137 Pfam match to entry PF00532.8 Peripla_BP_1 216596027138 Pfam match to entry PF00356.8 LacI 216596027139 Predicted helix-turn-helix motif with score 2103.000, SD 6.35 at aa 9-30, sequence RTIYDVAKAAGVSISTASNALN 216596027140 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 216596027141 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 216596027142 Pfam match to entry PF01547.11 SBP_bac_1 216596027143 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596027144 dimer interface [polypeptide binding]; other site 216596027145 conserved gate region; other site 216596027146 putative PBP binding loops; other site 216596027147 ABC-ATPase subunit interface; other site 216596027148 6 probable transmembrane helices predicted at aa 23-45, 85-107, 114-136,170-192, 227-249 and 278-300 216596027149 Pfam match to entry PF00528.10 BPD_transp_1 216596027150 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216596027151 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596027152 dimer interface [polypeptide binding]; other site 216596027153 conserved gate region; other site 216596027154 putative PBP binding loops; other site 216596027155 ABC-ATPase subunit interface; other site 216596027156 6 probable transmembrane helices predicted at aa 20-42, 85-107, 119-141,151-173, 194-216 and 254-276 216596027157 Pfam match to entry PF00528.10 BPD_transp_1 216596027158 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 216596027159 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 216596027160 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 216596027161 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 216596027162 Walker A/P-loop; other site 216596027163 ATP binding site [chemical binding]; other site 216596027164 Q-loop/lid; other site 216596027165 ABC transporter signature motif; other site 216596027166 Walker B; other site 216596027167 D-loop; other site 216596027168 H-loop/switch region; other site 216596027169 TOBE domain; Region: TOBE; pfam03459 216596027170 Pfam match to entry PF00005.11 ABC_tran 216596027171 Pfam match to entry PF03459.4 TOBE 216596027172 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 216596027173 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 216596027174 inhibitor site; inhibition site 216596027175 active site 216596027176 dimer interface [polypeptide binding]; other site 216596027177 catalytic residue [active] 216596027178 Pfam match to entry PF00701.10 DHDPS 216596027179 Transcriptional regulators [Transcription]; Region: FadR; COG2186 216596027180 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596027181 DNA-binding site [nucleotide binding]; DNA binding site 216596027182 FCD domain; Region: FCD; pfam07729 216596027183 Pfam match to entry PF00392.9 GntR 216596027184 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 216596027185 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 216596027186 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 216596027187 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 216596027188 active site 216596027189 Pfam match to entry PF00557.9 Peptidase_M24 216596027190 4 probable transmembrane helices predicted at aa 26-48, 68-87, 133-155 and 159-181 216596027191 Alpha-L-fucosidase; Region: Alpha_L_fucos; pfam01120 216596027192 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 216596027193 Pfam match to entry PF01120.7 Alpha_L_fucos 216596027194 Transcriptional regulators [Transcription]; Region: PurR; COG1609 216596027195 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216596027196 DNA binding site [nucleotide binding] 216596027197 domain linker motif; other site 216596027198 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 216596027199 ligand binding site [chemical binding]; other site 216596027200 dimerization interface [polypeptide binding]; other site 216596027201 Pfam match to entry PF00532.8 Peripla_BP_1 216596027202 Pfam match to entry PF00356.8 LacI 216596027203 Predicted helix-turn-helix motif with score 2484.000, SD 7.65 at aa 11-32, sequence ITIADVARAAGVSPMTVSRVLN 216596027204 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 216596027205 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 216596027206 1 probable transmembrane helix predicted at aa 12-31 216596027207 Pfam match to entry PF00496.9 SBP_bac_5 216596027208 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 216596027209 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596027210 dimer interface [polypeptide binding]; other site 216596027211 conserved gate region; other site 216596027212 putative PBP binding loops; other site 216596027213 ABC-ATPase subunit interface; other site 216596027214 6 probable transmembrane helices predicted at aa 9-31, 107-129, 141-163,192-214, 257-279 and 299-321 216596027215 Pfam match to entry PF00528.10 BPD_transp_1 216596027216 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 216596027217 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596027218 dimer interface [polypeptide binding]; other site 216596027219 conserved gate region; other site 216596027220 putative PBP binding loops; other site 216596027221 ABC-ATPase subunit interface; other site 216596027222 6 probable transmembrane helices predicted at aa 35-57, 176-198, 211-230,235-257, 288-310 and 346-365 216596027223 Pfam match to entry PF00528.10 BPD_transp_1 216596027224 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 216596027225 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596027226 Walker A/P-loop; other site 216596027227 ATP binding site [chemical binding]; other site 216596027228 Q-loop/lid; other site 216596027229 ABC transporter signature motif; other site 216596027230 Walker B; other site 216596027231 D-loop; other site 216596027232 H-loop/switch region; other site 216596027233 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216596027234 Pfam match to entry PF00005.11 ABC_tran 216596027235 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 216596027236 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596027237 Walker A/P-loop; other site 216596027238 ATP binding site [chemical binding]; other site 216596027239 Q-loop/lid; other site 216596027240 ABC transporter signature motif; other site 216596027241 Walker B; other site 216596027242 D-loop; other site 216596027243 H-loop/switch region; other site 216596027244 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 216596027245 Pfam match to entry PF00005.11 ABC_tran 216596027246 KduI/IolB family; Region: KduI; pfam04962 216596027247 Pfam match to entry PF06845.1 IolB 216596027248 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 216596027249 Pfam match to entry PF01229.7 Glyco_hydro_39 216596027250 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 216596027251 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167 216596027252 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 216596027253 putative ligand binding site [chemical binding]; other site 216596027254 putative NAD binding site [chemical binding]; other site 216596027255 catalytic site [active] 216596027256 Pfam match to entry PF02826.5 2-Hacid_dh_C 216596027257 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 216596027258 metal binding site [ion binding]; metal-binding site 216596027259 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 216596027260 Protein export membrane protein; Region: SecD_SecF; cl14618 216596027261 Pfam match to entry PF00873.7 ACR_tran 216596027262 12 probable transmembrane helices predicted at aa 7-29, 335-352, 359-381,385-406, 426-448, 458-480, 520-537, 844-866, 873-892,902-924, 945-967 and 977-999 216596027263 Signal peptide predicted for pRL100286 by SignalP 2.0 HMM (Signal peptide probabilty 0.983) with cleavage site probability 0.579 between residues 31 and 32 216596027264 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 216596027265 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 216596027266 HlyD family secretion protein; Region: HlyD_3; pfam13437 216596027267 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 216596027268 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596027269 active site 216596027270 phosphorylation site [posttranslational modification] 216596027271 intermolecular recognition site; other site 216596027272 dimerization interface [polypeptide binding]; other site 216596027273 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216596027274 DNA binding site [nucleotide binding] 216596027275 Pfam match to entry PF00072.10 Response_reg 216596027276 Pfam match to entry PF00486.12 Trans_reg_C 216596027277 HAMP domain; Region: HAMP; pfam00672 216596027278 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216596027279 dimer interface [polypeptide binding]; other site 216596027280 phosphorylation site [posttranslational modification] 216596027281 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596027282 ATP binding site [chemical binding]; other site 216596027283 Mg2+ binding site [ion binding]; other site 216596027284 G-X-G motif; other site 216596027285 1 probable transmembrane helix predicted at aa 5-27 216596027286 Pfam match to entry PF00672.10 HAMP 216596027287 Pfam match to entry PF00512.10 HisKA 216596027288 Pfam match to entry PF02518.9 HATPase_c 216596027289 FOG: CBS domain [General function prediction only]; Region: COG0517 216596027290 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 216596027291 Pfam match to entry PF00571.14 CBS 216596027292 Pfam match to entry PF00571.14 CBS 216596027293 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 216596027294 Pfam match to entry PF02321.6 OEP 216596027295 Pfam match to entry PF02321.6 OEP 216596027296 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 216596027297 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 216596027298 putative active site [active] 216596027299 putative catalytic site [active] 216596027300 Pfam match to entry PF01575.6 MaoC_dehydratas 216596027301 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 216596027302 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 216596027303 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 216596027304 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 216596027305 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 216596027306 carboxyltransferase (CT) interaction site; other site 216596027307 biotinylation site [posttranslational modification]; other site 216596027308 Pfam match to entry PF00364.9 Biotin_lipoyl 216596027309 Pfam match to entry PF02785.5 Biotin_carb_C 216596027310 Pfam match to entry PF02786.4 CPSase_L_D2 216596027311 Pfam match to entry PF00289.9 CPSase_L_chain 216596027312 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 216596027313 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 216596027314 Pfam match to entry PF01039.9 Carboxyl_trans 216596027315 isovaleryl-CoA dehydrogenase; Region: PLN02519 216596027316 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 216596027317 substrate binding site [chemical binding]; other site 216596027318 FAD binding site [chemical binding]; other site 216596027319 catalytic base [active] 216596027320 Pfam match to entry PF00441.11 Acyl-CoA_dh 216596027321 Pfam match to entry PF02770.6 Acyl-CoA_dh_M 216596027322 Pfam match to entry PF02771.6 Acyl-CoA_dh_N 216596027323 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 216596027324 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 216596027325 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 216596027326 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216596027327 Pfam match to entry PF00165.8 HTH_AraC 216596027328 Predicted helix-turn-helix motif with score 1221.000, SD 3.35 at aa 299-320, sequence SSFAELAADMRMPPSTLRHRLH 216596027329 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 216596027330 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 216596027331 NAD binding site [chemical binding]; other site 216596027332 homodimer interface [polypeptide binding]; other site 216596027333 homotetramer interface [polypeptide binding]; other site 216596027334 active site 216596027335 Pfam match to entry PF00106.11 adh_short 216596027336 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 216596027337 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 216596027338 dimer interface [polypeptide binding]; other site 216596027339 active site 216596027340 Pfam match to entry PF00108.10 Thiolase_N 216596027341 Pfam match to entry PF02803.5 Thiolase_C 216596027342 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216596027343 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216596027344 active site 216596027345 Pfam match to entry PF02771.6 Acyl-CoA_dh_N 216596027346 Pfam match to entry PF02770.6 Acyl-CoA_dh_M 216596027347 Pfam match to entry PF00441.11 Acyl-CoA_dh 216596027348 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573 216596027349 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 216596027350 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 216596027351 tetramer interface [polypeptide binding]; other site 216596027352 TPP-binding site [chemical binding]; other site 216596027353 heterodimer interface [polypeptide binding]; other site 216596027354 phosphorylation loop region [posttranslational modification] 216596027355 Pfam match to entry PF00676.8 E1_dh 216596027356 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 216596027357 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 216596027358 alpha subunit interface [polypeptide binding]; other site 216596027359 TPP binding site [chemical binding]; other site 216596027360 heterodimer interface [polypeptide binding]; other site 216596027361 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 216596027362 Pfam match to entry PF02779.8 Transket_pyr 216596027363 Pfam match to entry PF02780.6 Transketolase_C 216596027364 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 216596027365 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 216596027366 E3 interaction surface; other site 216596027367 lipoyl attachment site [posttranslational modification]; other site 216596027368 e3 binding domain; Region: E3_binding; pfam02817 216596027369 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 216596027370 Pfam match to entry PF00364.9 Biotin_lipoyl 216596027371 Pfam match to entry PF02817.4 E3_binding 216596027372 Pfam match to entry PF00198.10 2-oxoacid_dh 216596027373 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 216596027374 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 216596027375 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 216596027376 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 216596027377 Pfam match to entry PF00070.12 Pyr_redox 216596027378 Pfam match to entry PF02852.7 Pyr_redox_dim 216596027379 Similar to N-terminus to codon 117 of Rhizobium hedysari putative transposase SWALL:O30982 (EMBL:AF023675) (250 aa); similarity:fasta; SWALL:O30982 (EMBL:AF023675); Rhizobium hedysari; putative transposase; length 250 aa; 108 aa overlap; query 2-107 aa; subject 9-116 aa; putative transposase, pseudogene 216596027380 Similar, but truncated at the C and N-termini to Agrobacterium tumefaciens Tiorf75 protein SWALL:Q9R6I4 (EMBL:AB016260) (198 aa). Frameshift after codon 74; similarity:fasta; SWALL:Q9R6I4 (EMBL:AB016260); Agrobacterium tumefaciens; Tiorf75 protein; tiorf75; length 198 aa; 150 aa overlap; query 1-150 aa; subject 13-157 aa 216596027381 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 216596027382 Ca2+ binding site [ion binding]; other site 216596027383 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 216596027384 Ca2+ binding site [ion binding]; other site 216596027385 Pfam match to entry PF00353.8 HemolysinCabind 216596027386 Pfam match to entry PF00353.8 HemolysinCabind 216596027387 Pfam match to entry PF00353.8 HemolysinCabind 216596027388 Pfam match to entry PF00353.8 HemolysinCabind 216596027389 Pfam match to entry PF00353.8 HemolysinCabind 216596027390 Pfam match to entry PF00353.8 HemolysinCabind 216596027391 Pfam match to entry PF00353.8 HemolysinCabind 216596027392 Pfam match to entry PF00353.8 HemolysinCabind 216596027393 Pfam match to entry PF00353.8 HemolysinCabind 216596027394 Pfam match to entry PF00028.7 Cadherin 216596027395 Pfam match to entry PF00028.7 Cadherin 216596027396 submitted without /pseudo; similarity:fasta; SWALL:Q7D3X7 (EMBL:AE007881); Agrobacterium tumefaciens str. C58; Agr_pat_136p; length 234 aa; 166 aa overlap; query 14-179 aa; subject 21-185 aa 216596027397 Predicted membrane protein [Function unknown]; Region: COG2246 216596027398 GtrA-like protein; Region: GtrA; pfam04138 216596027399 Pfam match to entry PF04138.2 GtrA 216596027400 4 probable transmembrane helices predicted at aa 7-24, 28-50, 70-92 and 97-119 216596027401 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 216596027402 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216596027403 motif II; other site 216596027404 Pfam match to entry PF00702.10 Hydrolase 216596027405 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 216596027406 UbiA prenyltransferase family; Region: UbiA; pfam01040 216596027407 6 probable transmembrane helices predicted at aa 33-50, 54-76, 109-131,229-251, 258-275 and 295-317 216596027408 Pfam match to entry PF01040.7 UbiA 216596027409 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 216596027410 Pfam match to entry PF02604.5 PhdYeFM 216596027411 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 216596027412 PhnA protein; Region: PhnA; pfam03831 216596027413 Pfam match to entry PF03831.3 PhnA 216596027414 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 216596027415 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 216596027416 Pfam match to entry PF01402.8 HTH_4 216596027417 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 216596027418 ferrichrome receptor precursor protein; Provisional; Region: PRK14050 216596027419 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 216596027420 N-terminal plug; other site 216596027421 ligand-binding site [chemical binding]; other site 216596027422 Pfam match to entry PF00593.9 TonB_dep_Rec 216596027423 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 216596027424 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 216596027425 ABC-ATPase subunit interface; other site 216596027426 dimer interface [polypeptide binding]; other site 216596027427 putative PBP binding regions; other site 216596027428 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 216596027429 ABC-ATPase subunit interface; other site 216596027430 dimer interface [polypeptide binding]; other site 216596027431 putative PBP binding regions; other site 216596027432 Pfam match to entry PF01032.7 FecCD 216596027433 19 probable transmembrane helices predicted at aa 7-29, 51-73, 86-104, 114-132,139-161, 181-203, 224-241, 245-264, 271-290, 300-322,343-365, 385-407, 420-439, 443-462, 474-496, 511-533,565-587, 597-619 and 626-648 216596027434 Pfam match to entry PF01032.7 FecCD 216596027435 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 216596027436 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 216596027437 siderophore binding site; other site 216596027438 Pfam match to entry PF01497.7 Peripla_BP_2 216596027439 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 216596027440 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 216596027441 Walker A/P-loop; other site 216596027442 ATP binding site [chemical binding]; other site 216596027443 Q-loop/lid; other site 216596027444 ABC transporter signature motif; other site 216596027445 Walker B; other site 216596027446 D-loop; other site 216596027447 H-loop/switch region; other site 216596027448 Pfam match to entry PF00005.11 ABC_tran 216596027449 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 216596027450 Pfam match to entry PF00753.13 Lactamase_B 216596027451 1 probable transmembrane helix predicted at aa 180-202 216596027452 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 216596027453 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 216596027454 catalytic residues [active] 216596027455 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596027456 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596027457 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 216596027458 putative effector binding pocket; other site 216596027459 dimerization interface [polypeptide binding]; other site 216596027460 Pfam match to entry PF00126.10 HTH_1 216596027461 Predicted helix-turn-helix motif with score 1313.000, SD 3.66 at aa 19-40, sequence GSFTKAAERLAITKTVVSQQVA 216596027462 Pfam match to entry PF03466.5 LysR_substrate 216596027463 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 216596027464 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 216596027465 iron-sulfur cluster [ion binding]; other site 216596027466 [2Fe-2S] cluster binding site [ion binding]; other site 216596027467 Pfam match to entry PF00355.13 Rieske 216596027468 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 216596027469 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 216596027470 hydrophobic ligand binding site; other site 216596027471 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 216596027472 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 216596027473 putative C-terminal domain interface [polypeptide binding]; other site 216596027474 putative GSH binding site (G-site) [chemical binding]; other site 216596027475 putative dimer interface [polypeptide binding]; other site 216596027476 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 216596027477 N-terminal domain interface [polypeptide binding]; other site 216596027478 dimer interface [polypeptide binding]; other site 216596027479 substrate binding pocket (H-site) [chemical binding]; other site 216596027480 Pfam match to entry PF02798.6 GST_N 216596027481 Pfam match to entry PF00043.11 GST_C 216596027482 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 216596027483 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 216596027484 active site 216596027485 putative substrate binding pocket [chemical binding]; other site 216596027486 Pfam match to entry PF01979.7 Amidohydro_1 216596027487 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 216596027488 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 216596027489 putative ligand binding site [chemical binding]; other site 216596027490 Pfam match to entry PF02608.4 Bmp 216596027491 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 216596027492 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 216596027493 Walker A/P-loop; other site 216596027494 ATP binding site [chemical binding]; other site 216596027495 Q-loop/lid; other site 216596027496 ABC transporter signature motif; other site 216596027497 Walker B; other site 216596027498 D-loop; other site 216596027499 H-loop/switch region; other site 216596027500 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 216596027501 Pfam match to entry PF00005.11 ABC_tran 216596027502 Pfam match to entry PF00005.11 ABC_tran 216596027503 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596027504 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 216596027505 TM-ABC transporter signature motif; other site 216596027506 9 probable transmembrane helices predicted at aa 20-42, 64-86, 93-115, 125-147,154-176, 200-222, 250-272, 287-318 and 330-352 216596027507 Pfam match to entry PF02653.5 BPD_transp_2 216596027508 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596027509 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 216596027510 TM-ABC transporter signature motif; other site 216596027511 9 probable transmembrane helices predicted at aa 4-26, 33-55, 60-82, 89-106,140-162, 182-204, 209-231, 238-260 and 265-284 216596027512 Pfam match to entry PF02653.5 BPD_transp_2 216596027513 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 216596027514 nudix motif; other site 216596027515 Pfam match to entry PF00293.13 NUDIX 216596027516 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 216596027517 Pfam match to entry PF01865.6 PhoU_div 216596027518 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 216596027519 8 probable transmembrane helices predicted at aa 4-26, 46-68, 83-105, 112-131,141-163, 202-224, 273-295 and 308-330 216596027520 Pfam match to entry PF01384.9 PHO4 216596027521 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 216596027522 NMT1-like family; Region: NMT1_2; pfam13379 216596027523 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 216596027524 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596027525 dimer interface [polypeptide binding]; other site 216596027526 conserved gate region; other site 216596027527 putative PBP binding loops; other site 216596027528 ABC-ATPase subunit interface; other site 216596027529 6 probable transmembrane helices predicted at aa 42-64, 84-106, 111-133,166-188, 232-254 and 265-287 216596027530 Pfam match to entry PF00528.10 BPD_transp_1 216596027531 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 216596027532 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 216596027533 Walker A/P-loop; other site 216596027534 ATP binding site [chemical binding]; other site 216596027535 Q-loop/lid; other site 216596027536 ABC transporter signature motif; other site 216596027537 Walker B; other site 216596027538 D-loop; other site 216596027539 H-loop/switch region; other site 216596027540 Pfam match to entry PF00005.11 ABC_tran 216596027541 Transcriptional regulators [Transcription]; Region: GntR; COG1802 216596027542 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596027543 DNA-binding site [nucleotide binding]; DNA binding site 216596027544 FCD domain; Region: FCD; pfam07729 216596027545 Pfam match to entry PF00392.9 GntR 216596027546 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 216596027547 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 216596027548 putative ligand binding site [chemical binding]; other site 216596027549 Pfam match to entry PF02608.4 Bmp 216596027550 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 216596027551 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596027552 TM-ABC transporter signature motif; other site 216596027553 10 probable transmembrane helices predicted at aa 33-55, 70-92, 99-121, 131-153,160-182, 218-240, 261-283, 288-307, 312-331 and 341-363 216596027554 Pfam match to entry PF02653.5 BPD_transp_2 216596027555 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596027556 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 216596027557 TM-ABC transporter signature motif; other site 216596027558 7 probable transmembrane helices predicted at aa 7-29, 62-84, 97-119, 142-164,195-217, 237-259 and 272-294 216596027559 Pfam match to entry PF02653.5 BPD_transp_2 216596027560 formamidase; Provisional; Region: amiF; PRK13287 216596027561 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 216596027562 multimer interface [polypeptide binding]; other site 216596027563 active site 216596027564 catalytic triad [active] 216596027565 dimer interface [polypeptide binding]; other site 216596027566 Pfam match to entry PF00795.10 CN_hydrolase 216596027567 Isochorismatase family; Region: Isochorismatase; pfam00857 216596027568 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 216596027569 catalytic triad [active] 216596027570 conserved cis-peptide bond; other site 216596027571 Pfam match to entry PF00857.9 Isochorismatase 216596027572 Amidohydrolase ring-opening protein (Amido_AtzD_TrzD); Region: Amido_AtzD_TrzD; pfam09663 216596027573 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 216596027574 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 216596027575 Walker A/P-loop; other site 216596027576 ATP binding site [chemical binding]; other site 216596027577 Q-loop/lid; other site 216596027578 ABC transporter signature motif; other site 216596027579 Walker B; other site 216596027580 D-loop; other site 216596027581 H-loop/switch region; other site 216596027582 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 216596027583 Pfam match to entry PF00005.11 ABC_tran 216596027584 Pfam match to entry PF00005.11 ABC_tran 216596027585 Isochorismatase family; Region: Isochorismatase; pfam00857 216596027586 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 216596027587 catalytic triad [active] 216596027588 conserved cis-peptide bond; other site 216596027589 Pfam match to entry PF00857.9 Isochorismatase 216596027590 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 216596027591 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 216596027592 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 216596027593 Walker A/P-loop; other site 216596027594 ATP binding site [chemical binding]; other site 216596027595 Q-loop/lid; other site 216596027596 ABC transporter signature motif; other site 216596027597 Walker B; other site 216596027598 D-loop; other site 216596027599 H-loop/switch region; other site 216596027600 Pfam match to entry PF00005.11 ABC_tran 216596027601 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596027602 dimer interface [polypeptide binding]; other site 216596027603 conserved gate region; other site 216596027604 putative PBP binding loops; other site 216596027605 ABC-ATPase subunit interface; other site 216596027606 Pfam match to entry PF00528.10 BPD_transp_1 216596027607 5 probable transmembrane helices predicted at aa 20-42, 55-77, 87-106, 161-178 and 188-210 216596027608 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 216596027609 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596027610 dimer interface [polypeptide binding]; other site 216596027611 conserved gate region; other site 216596027612 putative PBP binding loops; other site 216596027613 ABC-ATPase subunit interface; other site 216596027614 Pfam match to entry PF00528.10 BPD_transp_1 216596027615 5 probable transmembrane helices predicted at aa 27-49, 62-84, 89-111, 155-177 and 197-219 216596027616 Predicted helix-turn-helix motif with score 1170.000, SD 3.17 at aa 125-146, sequence AGLVESAEMVGMTPVQIFRRIK 216596027617 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 216596027618 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 216596027619 substrate binding pocket [chemical binding]; other site 216596027620 membrane-bound complex binding site; other site 216596027621 hinge residues; other site 216596027622 Pfam match to entry PF00497.8 SBP_bac_3 216596027623 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 216596027624 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596027625 DNA-binding site [nucleotide binding]; DNA binding site 216596027626 UTRA domain; Region: UTRA; pfam07702 216596027627 Pfam match to entry PF00392.9 GntR 216596027628 Pfam match to entry PF07702.1 UTRA 216596027629 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 216596027630 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596027631 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216596027632 dimerization interface [polypeptide binding]; other site 216596027633 Pfam match to entry PF00126.10 HTH_1 216596027634 Predicted helix-turn-helix motif with score 1391.000, SD 3.92 at aa 24-45, sequence GGVTAAALELNVSPGAISQQVH 216596027635 Pfam match to entry PF03466.5 LysR_substrate 216596027636 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 216596027637 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 216596027638 active site 216596027639 non-prolyl cis peptide bond; other site 216596027640 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 216596027641 Pfam match to entry PF01613.6 Flavin_Reduct 216596027642 hypothetical protein; Provisional; Region: PRK07550 216596027643 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216596027644 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596027645 homodimer interface [polypeptide binding]; other site 216596027646 catalytic residue [active] 216596027647 Pfam match to entry PF00155.8 Aminotran_1_2 216596027648 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 216596027649 agmatinase; Region: agmatinase; TIGR01230 216596027650 oligomer interface [polypeptide binding]; other site 216596027651 putative active site [active] 216596027652 Mn binding site [ion binding]; other site 216596027653 Pfam match to entry PF00491.10 Arginase 216596027654 Isochorismatase family; Region: Isochorismatase; pfam00857 216596027655 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 216596027656 catalytic triad [active] 216596027657 conserved cis-peptide bond; other site 216596027658 Pfam match to entry PF00857.9 Isochorismatase 216596027659 CHASE4 domain; Region: CHASE4; cl01308 216596027660 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 216596027661 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216596027662 metal binding site [ion binding]; metal-binding site 216596027663 active site 216596027664 I-site; other site 216596027665 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 216596027666 Pfam match to entry PF00563.9 EAL 216596027667 Pfam match to entry PF00990.8 GGDEF 216596027668 2 probable transmembrane helices predicted at aa 29-51 and 294-316 216596027669 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 216596027670 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 216596027671 substrate binding pocket [chemical binding]; other site 216596027672 membrane-bound complex binding site; other site 216596027673 hinge residues; other site 216596027674 1 probable transmembrane helix predicted at aa 9-31 216596027675 Pfam match to entry PF00497.8 SBP_bac_3 216596027676 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 216596027677 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 216596027678 NAD binding site [chemical binding]; other site 216596027679 catalytic Zn binding site [ion binding]; other site 216596027680 structural Zn binding site [ion binding]; other site 216596027681 Pfam match to entry PF00107.11 ADH_zinc_N 216596027682 EamA-like transporter family; Region: EamA; pfam00892 216596027683 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 216596027684 EamA-like transporter family; Region: EamA; pfam00892 216596027685 9 probable transmembrane helices predicted at aa 25-47, 60-82, 87-109, 118-140,145-167, 174-193, 197-219, 226-248 and 253-272 216596027686 Pfam match to entry PF00892.8 DUF6 216596027687 Pfam match to entry PF00892.8 DUF6 216596027688 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596027689 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596027690 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216596027691 dimerization interface [polypeptide binding]; other site 216596027692 Pfam match to entry PF00126.10 HTH_1 216596027693 Predicted helix-turn-helix motif with score 1370.000, SD 3.85 at aa 24-45, sequence SNFSAAAQRIGRTQSAVSTQIK 216596027694 Pfam match to entry PF03466.5 LysR_substrate 216596027695 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 216596027696 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 216596027697 conserved cys residue [active] 216596027698 Pfam match to entry PF00165.8 HTH_AraC 216596027699 Pfam match to entry PF00165.8 HTH_AraC 216596027700 Predicted helix-turn-helix motif with score 1298.000, SD 3.61 at aa 285-306, sequence LVLARLARRVGISARHLQDLFQ 216596027701 Uncharacterized conserved protein [Function unknown]; Region: COG3246 216596027702 Pfam match to entry PF05853.1 DUF849 216596027703 bifunctional 3-hydroxyacyl-CoA dehydrogenase/thioesterase; Validated; Region: PRK07531 216596027704 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 216596027705 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 216596027706 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 216596027707 active site 216596027708 Pfam match to entry PF02737.6 3HCDH_N 216596027709 1 probable transmembrane helix predicted at aa 7-26 216596027710 Pfam match to entry PF00725.10 3HCDH 216596027711 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216596027712 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 216596027713 active site 216596027714 Pfam match to entry PF02771.6 Acyl-CoA_dh_N 216596027715 Pfam match to entry PF02770.6 Acyl-CoA_dh_M 216596027716 Pfam match to entry PF00441.11 Acyl-CoA_dh 216596027717 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 216596027718 CoA binding domain; Region: CoA_binding_2; pfam13380 216596027719 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 216596027720 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 216596027721 Pfam match to entry PF02629.7 CoA_binding 216596027722 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 216596027723 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216596027724 substrate binding site [chemical binding]; other site 216596027725 oxyanion hole (OAH) forming residues; other site 216596027726 trimer interface [polypeptide binding]; other site 216596027727 Pfam match to entry PF00378.8 ECH 216596027728 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 216596027729 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 216596027730 Pfam match to entry PF00496.9 SBP_bac_5 216596027731 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 216596027732 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596027733 dimer interface [polypeptide binding]; other site 216596027734 conserved gate region; other site 216596027735 ABC-ATPase subunit interface; other site 216596027736 6 probable transmembrane helices predicted at aa 21-43, 120-142, 154-176,191-213, 258-280 and 305-327 216596027737 Pfam match to entry PF00528.10 BPD_transp_1 216596027738 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 216596027739 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596027740 dimer interface [polypeptide binding]; other site 216596027741 conserved gate region; other site 216596027742 ABC-ATPase subunit interface; other site 216596027743 5 probable transmembrane helices predicted at aa 10-32, 73-95, 115-137, 194-216 and 236-258 216596027744 Pfam match to entry PF00528.10 BPD_transp_1 216596027745 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 216596027746 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596027747 Walker A/P-loop; other site 216596027748 ATP binding site [chemical binding]; other site 216596027749 Q-loop/lid; other site 216596027750 ABC transporter signature motif; other site 216596027751 Walker B; other site 216596027752 D-loop; other site 216596027753 H-loop/switch region; other site 216596027754 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596027755 Walker A/P-loop; other site 216596027756 ATP binding site [chemical binding]; other site 216596027757 Q-loop/lid; other site 216596027758 ABC transporter signature motif; other site 216596027759 Walker B; other site 216596027760 D-loop; other site 216596027761 H-loop/switch region; other site 216596027762 Pfam match to entry PF00005.11 ABC_tran 216596027763 Pfam match to entry PF00005.11 ABC_tran 216596027764 Predicted acyl esterases [General function prediction only]; Region: COG2936 216596027765 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 216596027766 Pfam match to entry PF02129.7 Peptidase_S15 216596027767 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 216596027768 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 216596027769 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216596027770 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 216596027771 DNA binding residues [nucleotide binding] 216596027772 Pfam match to entry PF04542.2 Sigma70_r2 216596027773 Pfam match to entry PF04545.3 Sigma70_r4 216596027774 Predicted helix-turn-helix motif with score 1587.000, SD 4.59 at aa 138-159, sequence LSHSAAADVMGCSEATVSWQVH 216596027775 von Willebrand factor; Region: vWF_A; pfam12450 216596027776 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 216596027777 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 216596027778 metal ion-dependent adhesion site (MIDAS); other site 216596027779 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 216596027780 Pfam match to entry PF00092.11 VWA 216596027781 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 216596027782 Strictosidine synthase; Region: Str_synth; pfam03088 216596027783 Pfam match to entry PF03758.3 SMP-30 216596027784 Transcriptional regulators [Transcription]; Region: PurR; COG1609 216596027785 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216596027786 DNA binding site [nucleotide binding] 216596027787 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 216596027788 putative dimerization interface [polypeptide binding]; other site 216596027789 putative ligand binding site [chemical binding]; other site 216596027790 Pfam match to entry PF00532.8 Peripla_BP_1 216596027791 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 216596027792 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 216596027793 putative NAD(P) binding site [chemical binding]; other site 216596027794 catalytic Zn binding site [ion binding]; other site 216596027795 Pfam match to entry PF00107.11 ADH_zinc_N 216596027796 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 216596027797 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 216596027798 putative ligand binding site [chemical binding]; other site 216596027799 NAD binding site [chemical binding]; other site 216596027800 catalytic site [active] 216596027801 Pfam match to entry PF02826.5 2-Hacid_dh_C 216596027802 Pfam match to entry PF00389.15 2-Hacid_dh 216596027803 gluconate 5-dehydrogenase; Provisional; Region: PRK07523 216596027804 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 216596027805 NADP binding site [chemical binding]; other site 216596027806 homodimer interface [polypeptide binding]; other site 216596027807 active site 216596027808 Pfam match to entry PF00106.11 adh_short 216596027809 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 216596027810 AAA domain; Region: AAA_33; pfam13671 216596027811 ATP-binding site [chemical binding]; other site 216596027812 Gluconate-6-phosphate binding site [chemical binding]; other site 216596027813 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 216596027814 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 216596027815 Pfam match to entry PF03446.3 NAD_binding_2 216596027816 1 probable transmembrane helix predicted at aa 9-26 216596027817 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 216596027818 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 216596027819 Walker A/P-loop; other site 216596027820 ATP binding site [chemical binding]; other site 216596027821 Q-loop/lid; other site 216596027822 ABC transporter signature motif; other site 216596027823 Walker B; other site 216596027824 D-loop; other site 216596027825 H-loop/switch region; other site 216596027826 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 216596027827 Pfam match to entry PF00005.11 ABC_tran 216596027828 Pfam match to entry PF00005.11 ABC_tran 216596027829 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216596027830 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596027831 TM-ABC transporter signature motif; other site 216596027832 9 probable transmembrane helices predicted at aa 28-50, 87-106, 111-133,140-159, 179-201, 231-250, 255-277, 284-306 and 310-332 216596027833 Pfam match to entry PF02653.5 BPD_transp_2 216596027834 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_6; cd06315 216596027835 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 216596027836 putative ligand binding site [chemical binding]; other site 216596027837 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 216596027838 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 216596027839 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 216596027840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 216596027841 6 probable transmembrane helices predicted at aa 30-52, 89-111, 124-141,146-165, 186-208 and 241-263 216596027842 Pfam match to entry PF00528.10 BPD_transp_1 216596027843 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 216596027844 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 216596027845 Walker A/P-loop; other site 216596027846 ATP binding site [chemical binding]; other site 216596027847 Q-loop/lid; other site 216596027848 ABC transporter signature motif; other site 216596027849 Walker B; other site 216596027850 D-loop; other site 216596027851 H-loop/switch region; other site 216596027852 Pfam match to entry PF00005.11 ABC_tran 216596027853 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 216596027854 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 216596027855 active site 216596027856 non-prolyl cis peptide bond; other site 216596027857 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 216596027858 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 216596027859 active site 216596027860 dimer interface [polypeptide binding]; other site 216596027861 non-prolyl cis peptide bond; other site 216596027862 insertion regions; other site 216596027863 Pfam match to entry PF00296.10 Bac_luciferase 216596027864 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 216596027865 HAMP domain; Region: HAMP; pfam00672 216596027866 dimerization interface [polypeptide binding]; other site 216596027867 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216596027868 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 216596027869 dimer interface [polypeptide binding]; other site 216596027870 putative CheW interface [polypeptide binding]; other site 216596027871 1 probable transmembrane helix predicted at aa 7-29 216596027872 Pfam match to entry PF00672.10 HAMP 216596027873 Pfam match to entry PF00015.9 MCPsignal 216596027874 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 216596027875 Na binding site [ion binding]; other site 216596027876 13 probable transmembrane helices predicted at aa 5-27, 48-70, 75-97, 130-152,167-189, 196-218, 233-255, 276-298, 325-347, 374-396,400-422, 427-446 and 461-483 216596027877 Pfam match to entry PF00474.7 SSF 216596027878 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 216596027879 2 probable transmembrane helices predicted at aa 65-83 and 93-115 216596027880 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 216596027881 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596027882 active site 216596027883 phosphorylation site [posttranslational modification] 216596027884 intermolecular recognition site; other site 216596027885 dimerization interface [polypeptide binding]; other site 216596027886 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216596027887 DNA binding residues [nucleotide binding] 216596027888 dimerization interface [polypeptide binding]; other site 216596027889 Pfam match to entry PF00196.8 GerE 216596027890 Pfam match to entry PF00072.10 Response_reg 216596027891 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 216596027892 Cache domain; Region: Cache_2; pfam08269 216596027893 Histidine kinase; Region: HisKA_3; pfam07730 216596027894 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596027895 ATP binding site [chemical binding]; other site 216596027896 Mg2+ binding site [ion binding]; other site 216596027897 G-X-G motif; other site 216596027898 Pfam match to entry PF02518.9 HATPase_c 216596027899 2 probable transmembrane helices predicted at aa 6-28 and 204-226 216596027900 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 216596027901 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216596027902 putative DNA binding site [nucleotide binding]; other site 216596027903 putative Zn2+ binding site [ion binding]; other site 216596027904 AsnC family; Region: AsnC_trans_reg; pfam01037 216596027905 Pfam match to entry PF01037.8 AsnC_trans_reg 216596027906 Predicted helix-turn-helix motif with score 1382.000, SD 3.89 at aa 21-42, sequence LKAETIAERIGLSVSAVQRRLK 216596027907 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 216596027908 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 216596027909 Walker A/P-loop; other site 216596027910 ATP binding site [chemical binding]; other site 216596027911 Q-loop/lid; other site 216596027912 ABC transporter signature motif; other site 216596027913 Walker B; other site 216596027914 D-loop; other site 216596027915 H-loop/switch region; other site 216596027916 Pfam match to entry PF00005.11 ABC_tran 216596027917 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 216596027918 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 216596027919 substrate binding pocket [chemical binding]; other site 216596027920 membrane-bound complex binding site; other site 216596027921 hinge residues; other site 216596027922 1 probable transmembrane helix predicted at aa 19-36 216596027923 Pfam match to entry PF00497.8 SBP_bac_3 216596027924 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 216596027925 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596027926 dimer interface [polypeptide binding]; other site 216596027927 ABC-ATPase subunit interface; other site 216596027928 putative PBP binding loops; other site 216596027929 5 probable transmembrane helices predicted at aa 22-44, 65-87, 102-121, 128-150 and 204-226 216596027930 Pfam match to entry PF00528.10 BPD_transp_1 216596027931 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 216596027932 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596027933 dimer interface [polypeptide binding]; other site 216596027934 conserved gate region; other site 216596027935 putative PBP binding loops; other site 216596027936 ABC-ATPase subunit interface; other site 216596027937 Pfam match to entry PF00528.10 BPD_transp_1 216596027938 4 probable transmembrane helices predicted at aa 15-37, 58-80, 90-112 and 193-215 216596027939 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040 216596027940 Pfam match to entry PF02574.5 S-methyl_trans 216596027941 Transcriptional regulator [Transcription]; Region: IclR; COG1414 216596027942 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 216596027943 Bacterial transcriptional regulator; Region: IclR; pfam01614 216596027944 Pfam match to entry PF01614.6 IclR 216596027945 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 216596027946 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 216596027947 putative ligand binding site [chemical binding]; other site 216596027948 1 probable transmembrane helix predicted at aa 55-77 216596027949 Pfam match to entry PF00532.8 Peripla_BP_1 216596027950 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 216596027951 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 216596027952 Walker A/P-loop; other site 216596027953 ATP binding site [chemical binding]; other site 216596027954 Q-loop/lid; other site 216596027955 ABC transporter signature motif; other site 216596027956 Walker B; other site 216596027957 D-loop; other site 216596027958 H-loop/switch region; other site 216596027959 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 216596027960 Pfam match to entry PF00005.11 ABC_tran 216596027961 Pfam match to entry PF00005.11 ABC_tran 216596027962 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216596027963 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596027964 TM-ABC transporter signature motif; other site 216596027965 9 probable transmembrane helices predicted at aa 24-46, 67-89, 99-121, 128-147,162-184, 214-236, 241-263, 270-289 and 294-316 216596027966 Pfam match to entry PF02653.5 BPD_transp_2 216596027967 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596027968 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216596027969 TM-ABC transporter signature motif; other site 216596027970 10 probable transmembrane helices predicted at aa 13-35, 39-61, 68-87, 92-114,121-143, 158-180, 210-232, 242-261, 263-285 and 289-308 216596027971 Pfam match to entry PF02653.5 BPD_transp_2 216596027972 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 216596027973 Amidohydrolase; Region: Amidohydro_2; pfam04909 216596027974 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 216596027975 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 216596027976 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 216596027977 catalytic residue [active] 216596027978 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 216596027979 homotrimer interaction site [polypeptide binding]; other site 216596027980 putative active site [active] 216596027981 Pfam match to entry PF01042.8 Ribonuc_L-PSP 216596027982 Predicted deacylase [General function prediction only]; Region: COG3608 216596027983 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252 216596027984 putative active site [active] 216596027985 Zn binding site [ion binding]; other site 216596027986 Pfam match to entry PF04952.4 AstE_AspA 216596027987 hypothetical protein; Validated; Region: PRK06201 216596027988 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 216596027989 Pfam match to entry PF03737.4 Methyltransf_6 216596027990 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 216596027991 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 216596027992 substrate binding pocket [chemical binding]; other site 216596027993 membrane-bound complex binding site; other site 216596027994 hinge residues; other site 216596027995 Pfam match to entry PF00497.8 SBP_bac_3 216596027996 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 216596027997 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 216596027998 Walker A/P-loop; other site 216596027999 ATP binding site [chemical binding]; other site 216596028000 Q-loop/lid; other site 216596028001 ABC transporter signature motif; other site 216596028002 Walker B; other site 216596028003 D-loop; other site 216596028004 H-loop/switch region; other site 216596028005 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216596028006 Pfam match to entry PF00005.11 ABC_tran 216596028007 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596028008 dimer interface [polypeptide binding]; other site 216596028009 conserved gate region; other site 216596028010 putative PBP binding loops; other site 216596028011 ABC-ATPase subunit interface; other site 216596028012 Pfam match to entry PF00528.10 BPD_transp_1 216596028013 5 probable transmembrane helices predicted at aa 31-53, 66-88, 103-125, 146-168 and 198-220 216596028014 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 216596028015 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596028016 dimer interface [polypeptide binding]; other site 216596028017 conserved gate region; other site 216596028018 putative PBP binding loops; other site 216596028019 ABC-ATPase subunit interface; other site 216596028020 Pfam match to entry PF00528.10 BPD_transp_1 216596028021 4 probable transmembrane helices predicted at aa 25-47, 68-90, 94-116 and 201-223 216596028022 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 216596028023 classical (c) SDRs; Region: SDR_c; cd05233 216596028024 NAD(P) binding site [chemical binding]; other site 216596028025 active site 216596028026 Pfam match to entry PF00106.11 adh_short 216596028027 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 216596028028 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596028029 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 216596028030 putative dimerization interface [polypeptide binding]; other site 216596028031 Pfam match to entry PF00126.10 HTH_1 216596028032 Predicted helix-turn-helix motif with score 1693.000, SD 4.95 at aa 47-68, sequence GSITRAADLLHIAQPALSQQLA 216596028033 Pfam match to entry PF03466.5 LysR_substrate 216596028034 aspartate aminotransferase; Provisional; Region: PRK05764 216596028035 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 216596028036 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596028037 homodimer interface [polypeptide binding]; other site 216596028038 catalytic residue [active] 216596028039 Pfam match to entry PF00155.8 Aminotran_1_2 216596028040 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 216596028041 putative active site [active] 216596028042 Pfam match to entry PF03746.4 LamB_YcsF 216596028043 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 216596028044 Pfam match to entry PF02626.5 AHS2 216596028045 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 216596028046 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 216596028047 Pfam match to entry PF02682.5 AHS1 216596028048 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 216596028049 acetyl-CoA carboxylase, biotin carboxyl carrier protein; Region: BCCP; TIGR00531 216596028050 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 216596028051 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 216596028052 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 216596028053 ATP-grasp domain; Region: ATP-grasp_4; cl17255 216596028054 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 216596028055 Pfam match to entry PF02785.5 Biotin_carb_C 216596028056 Pfam match to entry PF02786.4 CPSase_L_D2 216596028057 Pfam match to entry PF00289.9 CPSase_L_chain 216596028058 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 216596028059 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 216596028060 carboxyltransferase (CT) interaction site; other site 216596028061 biotinylation site [posttranslational modification]; other site 216596028062 Pfam match to entry PF00364.9 Biotin_lipoyl 216596028063 Transcriptional regulators [Transcription]; Region: PurR; COG1609 216596028064 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216596028065 DNA binding site [nucleotide binding] 216596028066 domain linker motif; other site 216596028067 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 216596028068 dimerization interface [polypeptide binding]; other site 216596028069 ligand binding site [chemical binding]; other site 216596028070 Pfam match to entry PF00532.8 Peripla_BP_1 216596028071 Pfam match to entry PF00356.8 LacI 216596028072 Signal peptide predicted for pRL100438 by SignalP 2.0 HMM (Signal peptide probabilty 0.639) with cleavage site probability 0.536 between residues 21 and 22 216596028073 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 216596028074 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 216596028075 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 216596028076 Pfam match to entry PF01547.11 SBP_bac_1 216596028077 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 216596028078 6 probable transmembrane helices predicted at aa 38-60, 97-119, 132-151,180-202, 223-245 and 288-310 216596028079 Pfam match to entry PF00528.10 BPD_transp_1 216596028080 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216596028081 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596028082 dimer interface [polypeptide binding]; other site 216596028083 conserved gate region; other site 216596028084 putative PBP binding loops; other site 216596028085 ABC-ATPase subunit interface; other site 216596028086 6 probable transmembrane helices predicted at aa 20-42, 91-113, 120-142,157-179, 199-221 and 262-284 216596028087 Pfam match to entry PF00528.10 BPD_transp_1 216596028088 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 216596028089 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 216596028090 Walker A/P-loop; other site 216596028091 ATP binding site [chemical binding]; other site 216596028092 Q-loop/lid; other site 216596028093 ABC transporter signature motif; other site 216596028094 Walker B; other site 216596028095 D-loop; other site 216596028096 H-loop/switch region; other site 216596028097 TOBE domain; Region: TOBE_2; pfam08402 216596028098 Pfam match to entry PF00005.11 ABC_tran 216596028099 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 216596028100 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 216596028101 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 216596028102 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 216596028103 Pfam match to entry PF03976.3 DUF344 216596028104 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 216596028105 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 216596028106 active site 216596028107 catalytic tetrad [active] 216596028108 Pfam match to entry PF00248.9 Aldo_ket_red 216596028109 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596028110 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596028111 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 216596028112 putative effector binding pocket; other site 216596028113 putative dimerization interface [polypeptide binding]; other site 216596028114 Pfam match to entry PF00126.10 HTH_1 216596028115 Pfam match to entry PF03466.5 LysR_substrate 216596028116 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 216596028117 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 216596028118 Pfam match to entry PF01243.8 Pyridox_oxidase 216596028119 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 216596028120 Pfam match to entry PF01165.7 Ribosomal_S21 216596028121 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 216596028122 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 216596028123 TPP-binding site [chemical binding]; other site 216596028124 dimer interface [polypeptide binding]; other site 216596028125 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 216596028126 PYR/PP interface [polypeptide binding]; other site 216596028127 dimer interface [polypeptide binding]; other site 216596028128 TPP binding site [chemical binding]; other site 216596028129 Pfam match to entry PF02780.6 Transketolase_C 216596028130 Pfam match to entry PF02779.8 Transket_pyr 216596028131 Pfam match to entry PF00456.9 Transketolase_N 216596028132 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216596028133 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 216596028134 DNA binding residues [nucleotide binding] 216596028135 dimerization interface [polypeptide binding]; other site 216596028136 Pfam match to entry PF00989.11 PAS 216596028137 Pfam match to entry PF00196.8 GerE 216596028138 Predicted helix-turn-helix motif with score 1054.000, SD 2.78 at aa 366-387, sequence MNLPEIALALGISSNTVKTHAG 216596028139 AAA ATPase domain; Region: AAA_16; pfam13191 216596028140 Archaeal ATPase; Region: Arch_ATPase; pfam01637 216596028141 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 216596028142 Pfam match to entry PF03008.4 DUF234 216596028143 Pfam match to entry PF01637.7 Arch_ATPase 216596028144 Similar to codons 350 to 500 of Bradyrhizobium japonicum USDA 110 two-component hybrid sensor and regulator SWALL:Q89D25 (EMBL:AP005962) (528 aa); similarity:fasta; SWALL:Q89D25 (EMBL:AP005962); Bradyrhizobium japonicum USDA 110; two-component hybrid sensor and regulator; length 528 aa; 147 aa overlap; query 5-150 aa; subject 353-498 aa 216596028145 Pfam match to entry PF02518.9 HATPase_c 216596028146 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216596028147 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216596028148 Pfam match to entry PF00440.8 TetR_N 216596028149 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 216596028150 dimer interface [polypeptide binding]; other site 216596028151 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216596028152 Pfam match to entry PF00903.11 Glyoxalase 216596028153 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 216596028154 classical (c) SDRs; Region: SDR_c; cd05233 216596028155 NAD(P) binding site [chemical binding]; other site 216596028156 active site 216596028157 Pfam match to entry PF00106.11 adh_short 216596028158 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 216596028159 classical (c) SDRs; Region: SDR_c; cd05233 216596028160 NAD(P) binding site [chemical binding]; other site 216596028161 active site 216596028162 Pfam match to entry PF00106.11 adh_short 216596028163 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216596028164 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216596028165 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596028166 TM-ABC transporter signature motif; other site 216596028167 12 probable transmembrane helices predicted at aa 44-63, 73-95, 102-121,125-147, 154-173, 193-215, 235-254, 259-278, 306-328,338-360, 365-387 and 392-409 216596028168 Pfam match to entry PF02653.5 BPD_transp_2 216596028169 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 216596028170 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 216596028171 Walker A/P-loop; other site 216596028172 ATP binding site [chemical binding]; other site 216596028173 Q-loop/lid; other site 216596028174 ABC transporter signature motif; other site 216596028175 Walker B; other site 216596028176 D-loop; other site 216596028177 H-loop/switch region; other site 216596028178 Pfam match to entry PF00005.11 ABC_tran 216596028179 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 216596028180 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 216596028181 putative ligand binding site [chemical binding]; other site 216596028182 Pfam match to entry PF00532.8 Peripla_BP_1 216596028183 1 probable transmembrane helix predicted at aa 50-72 216596028184 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 216596028185 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 216596028186 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216596028187 Pfam match to entry PF00165.8 HTH_AraC 216596028188 Pfam match to entry PF00165.8 HTH_AraC 216596028189 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 216596028190 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216596028191 active site 216596028192 motif I; other site 216596028193 motif II; other site 216596028194 Pfam match to entry PF02358.5 Trehalose_PPase 216596028195 Protein of unknown function (DUF972); Region: DUF972; pfam06156 216596028196 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 216596028197 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 216596028198 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 216596028199 DNA binding residues [nucleotide binding] 216596028200 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 216596028201 P-loop; other site 216596028202 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 216596028203 Magnesium ion binding site [ion binding]; other site 216596028204 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 216596028205 Magnesium ion binding site [ion binding]; other site 216596028206 HMMPfam:PF01656;CobQ/CobB/MinD/ParA nucleotide binding domai;1.2e-60;codon 144-379; HMMPfam hit to PF01656, CobQ/CobB/MinD/ParA nucleotide binding domai 216596028207 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 216596028208 ParB-like nuclease domain; Region: ParBc; pfam02195 216596028209 HMMPfam:PF02195;ParB-like nuclease domain;9.1e-29;codon 78-166; HMMPfam hit to PF02195, ParB-like nuclease domain 216596028210 HMMPfam:PF07506;RepB plasmid partitioning protein;1.8e-23;codon 167-331; HMMPfam hit to PF07506, RepB plasmid partitioning protein 216596028211 replication initiation protein RepC; Provisional; Region: PRK13824 216596028212 Replication protein C N-terminal domain; Region: RP-C; pfam03428 216596028213 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 216596028214 HMMPfam:PF03428;Replication protein C;1.9e-260;codon 2-399; HMMPfam hit to PF03428, Replication protein C 216596028215 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 216596028216 Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459 216596028217 ParB-like nuclease domain; Region: ParBc; pfam02195 216596028218 HMMPfam:PF02195;ParB-like nuclease domain;4.6e-07;codon 14-116; HMMPfam hit to PF02195, ParB-like nuclease domain 216596028219 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596028220 S-adenosylmethionine binding site [chemical binding]; other site 216596028221 P-loop containing NTP hydrolase pore-1; Region: AAA_34; pfam13872 216596028222 Helicase_C-like; Region: Helicase_C_4; pfam13871 216596028223 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 216596028224 active site 216596028225 metal binding site [ion binding]; metal-binding site 216596028226 interdomain interaction site; other site 216596028227 Protein of unknown function (DUF2493); Region: DUF2493; pfam10686 216596028228 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 216596028229 PemK-like protein; Region: PemK; cl00995 216596028230 Uncharacterized conserved protein [Function unknown]; Region: COG5489 216596028231 HMMPfam:PF05284;Protein of unknown function (DUF736);2.3e-49;codon 27-130; HMMPfam hit to PF05284, Protein of unknown function (DUF736) 216596028232 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 216596028233 IHF dimer interface [polypeptide binding]; other site 216596028234 IHF - DNA interface [nucleotide binding]; other site 216596028235 HMMPfam:PF00216;Bacterial DNA-binding protein;2.7e-32;codon 2-91; HMMPfam hit to PF00216, Bacterial DNA-binding protein 216596028236 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 216596028237 HMMPfam:PF05406;WGR domain;6.8e-36;codon 13-96; HMMPfam hit to PF05406, WGR domain 216596028238 HMMPfam:PF01656;CobQ/CobB/MinD/ParA nucleotide binding domai;1.2e-60;codon 144-379; HMMPfam hit to PF01656, CobQ/CobB/MinD/ParA nucleotide binding domai 216596028239 hypothetical protein; Provisional; Region: PRK10756 216596028240 DDE domain; Region: DDE_Tnp_IS240; pfam13610 216596028241 Integrase core domain; Region: rve; pfam00665 216596028242 VirE2; Region: VirE2; cl09429 216596028243 VirE3; Region: VirE3; pfam06661 216596028244 HMMPfam:PF06661;VirE3;5.3e-107;codon 58-372; HMMPfam hit to PF06661, VirE3 216596028245 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 216596028246 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 216596028247 HTH-like domain; Region: HTH_21; pfam13276 216596028248 Integrase core domain; Region: rve; pfam00665 216596028249 Integrase core domain; Region: rve_3; pfam13683 216596028250 HMMPfam:PF00665;Integrase core domain;6.3e-41;codon 112-270; HMMPfam hit to PF00665, Integrase core domain 216596028251 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 216596028252 DNA-binding interface [nucleotide binding]; DNA binding site 216596028253 HMMPfam:PF01527;Transposase;4.3e-18;codon 2-66; HMMPfam hit to PF01527, Transposase 216596028254 Winged helix-turn helix; Region: HTH_29; pfam13551 216596028255 Homeodomain-like domain; Region: HTH_23; pfam13384 216596028256 Homeodomain-like domain; Region: HTH_32; pfam13565 216596028257 Similar to Flavobacterium sp. ATCC 27551 IstA putative transposase. UniProt:Q8GC47_9FLAO (EMBL:FSP421424) (507 aa), and to Agrobacterium tumefaciens (strain C58/ATCC 33970) IstA IS21 family transposase (agr_l_49p). UniProt:Q8U6E5_AGRT5 (EMBL:AE008199) (498 aa); similarity:fasta; with=UniProt:Q8GC47_9FLAO (EMBL:FSP421424); Flavobacterium sp. ATCC 27551.; istA; Putative transposase.; length=507; id 46.843; 491 aa overlap; query 1-426; subject 4-494; similarity:fasta; with=UniProt:Q8U6E5_AGRT5 (EMBL:AE008199); Agrobacterium tumefaciens (strain C58/ATCC 33970).; istA; IS21 family transposase (AGR_L_49p).; length=498; id 78.514; 498 aa overlap; query 1-434; subject 1-498; putative transposase related protein,pseudogene 216596028258 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 216596028259 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 216596028260 Walker A motif; other site 216596028261 ATP binding site [chemical binding]; other site 216596028262 Walker B motif; other site 216596028263 arginine finger; other site 216596028264 HMMPfam:PF01695;IstB-like ATP binding protein;9.6e-74;codon 57-234; HMMPfam hit to PF01695, IstB-like ATP binding protein 216596028265 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 216596028266 MerR family regulatory protein; Region: MerR; pfam00376 216596028267 DNA binding residues [nucleotide binding] 216596028268 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 216596028269 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 216596028270 P-loop; other site 216596028271 Magnesium ion binding site [ion binding]; other site 216596028272 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 216596028273 Magnesium ion binding site [ion binding]; other site 216596028274 HMMPfam:PF00376;MerR family regulatory protein;5e-10;codon 55-92; HMMPfam hit to PF00376, MerR family regulatory protein 216596028275 HMMPfam:PF01656;CobQ/CobB/MinD/ParA nucleotide binding domai;2.3e-33;codon 129-371; HMMPfam hit to PF01656, CobQ/CobB/MinD/ParA nucleotide binding domai 216596028276 replication initiation protein RepC; Provisional; Region: PRK13824 216596028277 Replication protein C N-terminal domain; Region: RP-C; pfam03428 216596028278 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 216596028279 HMMPfam:PF03428;Replication protein C;2e-209;codon 2-399; HMMPfam hit to PF03428, Replication protein C 216596028280 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 216596028281 Transposase; Region: HTH_Tnp_1; pfam01527 216596028282 HMMPfam:PF01527;Transposase;6.5e-09;codon 13-98; HMMPfam hit to PF01527, Transposase 216596028283 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 216596028284 Transposase; Region: HTH_Tnp_1; pfam01527 216596028285 HMMPfam:PF01527;Transposase;5.5e-16;codon 28-112; HMMPfam hit to PF01527, Transposase 216596028286 putative transposase for insertion sequence,pseudogene; N-terminus to codon 22 is similar to the N-terminus to codon 22 of Rhizobium loti (Mesorhizobium loti) msi300 putative transposase number 2 for insertion sequence. UniProt:Q8KJ94_RHILO (EMBL:MLO672114) (118 aa); similarity:fasta; with=UniProt:Q8KJ94_RHILO (EMBL:MLO672114); Rhizobium loti (Mesorhizobium loti).; msi300; PUTATIVE TRANSPOSASE NUMBER 2 FOR INSERTION SEQUENCE.; length=118; id 70.000; 20 aa overlap; query 1-20; subject 1-20 216596028287 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 216596028288 active site 216596028289 Int/Topo IB signature motif; other site 216596028290 DNA binding site [nucleotide binding] 216596028291 HMMPfam:PF00589;Phage integrase family;1.3e-08;codon 60-213; HMMPfam hit to PF00589, Phage integrase family 216596028292 HMMPfam:PF02899;Phage integrase, N-terminal SAM-like;0.23;codon 8-94; HMMPfam hit to PF02899, Phage integrase, N-terminal SAM-like 216596028293 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 216596028294 active site 216596028295 DNA binding site [nucleotide binding] 216596028296 Int/Topo IB signature motif; other site 216596028297 HMMPfam:PF00589;Phage integrase family;3.4e-11;codon 93-281; HMMPfam hit to PF00589, Phage integrase family 216596028298 pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188 216596028299 Int/Topo IB signature motif; other site 216596028300 HMMPfam:PF00589;Phage integrase family;3e-12;codon 96-271; HMMPfam hit to PF00589, Phage integrase family 216596028301 putative group II intron maturase, pseudogene; Similar to codons 255 to the C-terminus of Pseudomonas putida (strain KT2440) group II intron-encoding maturase, putative. UniProt:Q88EL6_PSEPK (EMBL:AE016790) (373 aa). This gene has been interrupted after codon 57 by a repetitive transposable element region; similarity:fasta; with=UniProt:Q88EL6_PSEPK (EMBL:AE016790); Pseudomonas putida (strain KT2440).; Group II intron-encoding maturase, putative.; length=373; id 60.526; 114 aa overlap; query 1-114; subject 253-366 216596028302 DDE superfamily endonuclease; Region: DDE_3; pfam13358 216596028303 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 216596028304 conserved hypothetical protein, pseudogene; This CDS has been interrupted by the insertion of a repetitive insertion element after codon 56; similarity:fasta; with=UniProt:Y4PG_RHISN (EMBL:RSAE95); Rhizobium sp. (strain NGR234).; Hypothetical 21.1 kDa protein y4pG/y4sC.; length=192; id 76.316; 190 aa overlap; query 1-190; subject 1-190 216596028305 Transposase; Region: HTH_Tnp_1; pfam01527 216596028306 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 216596028307 HMMPfam:PF01527;Transposase;2.6e-14;codon 29-103; HMMPfam hit to PF01527, Transposase 216596028308 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 216596028309 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 216596028310 HMMPfam:PF05717;IS66 Orf2 like protein;3.9e-63;codon 4-113; HMMPfam hit to PF05717, IS66 Orf2 like protein 216596028311 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 216596028312 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 216596028313 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 216596028314 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 216596028315 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 216596028316 HMMPfam:PF03050;Transposase IS66 family;9.2e-112;codon 143-346; HMMPfam hit to PF03050, Transposase IS66 family 216596028317 3 probable transmembrane helices predicted at aa 15-37, 42-64 and 116-138 216596028318 putative transposase-related protein,pseudogene; Similar to N-terminus of Pseudomonas putida (strain KT2440) transposase family protein. transposase family protein. UniProt:Q88IM4_PSEPK (EMBL:AE016785) (88 aa); similarity:fasta; with=UniProt:Q88IM4_PSEPK (EMBL:AE016785); Pseudomonas putida (strain KT2440).; Transposase family protein. Transposase family protein.; length=88; id 76.190; 21 aa overlap; query 1-21; subject 1-21 216596028319 DDE domain; Region: DDE_Tnp_IS240; pfam13610 216596028320 1 probable transmembrane helix predicted at aa 64-86 216596028321 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 216596028322 HMMPfam:PF01609;Transposase DDE domain;0.00032;codon 1-146; HMMPfam hit to PF01609, Transposase DDE domain 216596028323 Similar to N-terminus to codon 285 of Burkholderia cepacia (Pseudomonas cepacia) transposase. UniProt:Q45111_BURCE (EMBL:BCU44828) (419 aa), and similar to the N-terminus to codon 270 of Rhizobium sp. (strain NGR234) probable transposase for insertion sequence element IsrM3-like. UniProt:Y4PO_RHISN (EMBL:RSAE91) (400 aa); similarity:fasta; with=UniProt:Q45111_BURCE (EMBL:BCU44828); Burkholderia cepacia (Pseudomonas cepacia).; Transposase.; length=419; id 62.857; 280 aa overlap; query 3-267; subject 4-281; similarity:fasta; with=UniProt:Y4PO_RHISN (EMBL:RSAE91); Rhizobium sp. (strain NGR234).; Probable transposase for insertion sequence element ISRM3-like.; length=400; id 69.732; 261 aa overlap; query 9-266; subject 3-263; putative transposase, pseudogene 216596028324 HMMPfam:PF00872;Transposase, Mutator family;5.6e-78;codon 8-275; HMMPfam hit to PF00872, Transposase, Mutator family 216596028325 DDE domain; Region: DDE_Tnp_IS240; pfam13610 216596028326 Similar to codons 335 to the C-terminus of Rhizobium etli RepC. UniProt:O33979_RHIET (EMBL:U80928) (402 aa),and similar to codons 110 to the C-terminus of Rhizobium etli putative RepC (fragment). UniProt:O34300_RHIET (EMBL:U56723) (173 aa); similarity:fasta; with=UniProt:O33979_RHIET (EMBL:U80928); Rhizobium etli.; repC; RepC.; length=402; id 63.636; 66 aa overlap; query 3-68; subject 337-402; similarity:fasta; with=UniProt:O34300_RHIET (EMBL:U56723); Rhizobium etli.; Putative repC (Fragment).; length=173; id 73.016; 63 aa overlap; query 6-68; subject 111-173; putative replication protein, pseudogene 216596028327 conserved hypothetical protein, pseudogene; Similar to N-terminus to codon 45 of Agrobacterium tumefaciens ynh. UniProt:O52518_9RHIZ (EMBL:AF242881) (159 aa); similarity:fasta; with=UniProt:O52518_9RHIZ (EMBL:AF242881); Agrobacterium tumefaciens.; Ynh.; length=159; id 75.000; 28 aa overlap; query 15-41; subject 27-54 216596028328 Similar to codons 250 to 390 of Rhizobium meliloti (Sinorhizobium meliloti) transposase for insertion sequence element isrm3. UniProt:TRA3_RHIME (EMBL:AE007217) (400 aa),and to codons 110 to 250 of Rhizobium meliloti (Sinorhizobium meliloti) trm3 transposase. UniProt:Q92ZF8_RHIME (EMBL:AE007243) (262 aa). Frameshift after codon 36 and codon 93; similarity:fasta; with=UniProt:TRA3_RHIME (EMBL:AE007217); Rhizobium meliloti (Sinorhizobium meliloti).; Transposase for insertion sequence element ISRM3.; length=400; id 66.429; 140 aa overlap; query 1-140; subject 249-388; similarity:fasta; with=UniProt:Q92ZF8_RHIME (EMBL:AE007243); Rhizobium meliloti (Sinorhizobium meliloti).; TRm3 transposase.; length=262; id 66.429; 140 aa overlap; query 1-140; subject 111-250; putative transposase for insertion sequence element, pseudogene 216596028329 N-terminus to codon 85 is similar to codons 125 to 210 of Cupriavidus oxalaticus putative transposase. UniProt:Q84ES2_9BURK (EMBL:ROX536756) (381 aa), and N-terminus to codon 78 is similar to codon 110 to the C-terminus of Sphingomonas sp dxni hypothetical protein dxni (fragment). UniProt:Q9ZAL9_9SPHN (EMBL:SPDBFB) (185 aa); similarity:fasta; with=UniProt:Q84ES2_9BURK (EMBL:ROX536756); Cupriavidus oxalaticus.; Putative transposase.; length=381; id 67.073; 82 aa overlap; query 1-82; subject 125-206; similarity:fasta; with=UniProt:Q9ZAL9_9SPHN (EMBL:SPDBFB); Sphingomonas sp.; dxnI; Hypothetical protein dxnI (Fragment).; length=185; id 84.211; 76 aa overlap; query 1-76; subject 110-185; putative transposase-related protein,pseudogene 216596028330 putative insertion sequence related protein,pseudogene; Similar to codons 150 to 210 of Agrobacterium tumefaciens (strain C58/ATCC 33970) tnp* IS5 family transposase (agr_pat_136p). UniProt:Q8UKK9_AGRT5 (EMBL:AE007881) (234 aa); similarity:fasta; with=UniProt:Q8UKK9_AGRT5 (EMBL:AE007881); Agrobacterium tumefaciens (strain C58/ATCC 33970).; tnp*; IS5 family transposase (AGR_pAT_136p).; length=234; id 91.071; 56 aa overlap; query 1-56; subject 149-204 216596028331 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 216596028332 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 216596028333 Integrase core domain; Region: rve; pfam00665 216596028334 DDE domain; Region: DDE_Tnp_IS240; pfam13610 216596028335 HMMPfam:PF00665;Integrase core domain;2e-09;codon 40-188; HMMPfam hit to PF00665, Integrase core domain 216596028336 Similar to Agrobacterium tumefaciens virc1 virc1. UniProt:Q8VT89_9RHIZ (EMBL:AF329849) (231 aa), and to Agrobacterium rhizogenes virc1 virc1 protein. UniProt:VIRC1_AGRRH (EMBL:ARVIRCD) (231 aa); similarity:fasta; with=UniProt:Q8VT89_9RHIZ (EMBL:AF329849); Agrobacterium tumefaciens.; virC1; VirC1.; length=231; id 62.385; 109 aa overlap; query 1-109; subject 1-109; similarity:fasta; with=UniProt:VIRC1_AGRRH (EMBL:ARVIRCD); Agrobacterium rhizogenes.; VirC1 protein.; length=231; id 64.220; 109 aa overlap; query 1-109; subject 1-109 216596028337 UNKNOWN FEATURE KEY ???; Signal peptide predicted for pRL70071 by SignalP 2.0 HMM (Signal peptide probability 0.961) with cleavage site probability 0.936 between residues 38 and 39 216596028338 type IV secretion system protein VirD4; Provisional; Region: PRK13850 216596028339 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 216596028340 Walker A motif; other site 216596028341 ATP binding site [chemical binding]; other site 216596028342 Walker B motif; other site 216596028343 3 probable transmembrane helices predicted at aa 20-42, 78-100 and 167-186 216596028344 HMMPfam:PF02534;TraG/TraD family;3e-188;codon 110-589; HMMPfam hit to PF02534, TraG/TraD family 216596028345 submitted without /pseudo; putative transposase, pseudogene; similarity:fasta; with=UniProt:P72290_RHILE (EMBL:RLRMS); Rhizobium leguminosarum.; Transposase.; length=202; id 80.000; 190 aa overlap; query 17-201; subject 14-200 216596028346 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216596028347 dimer interface [polypeptide binding]; other site 216596028348 phosphorylation site [posttranslational modification] 216596028349 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596028350 ATP binding site [chemical binding]; other site 216596028351 Mg2+ binding site [ion binding]; other site 216596028352 G-X-G motif; other site 216596028353 HMMPfam:PF00512;His Kinase A (phosphoacceptor) domain;0.00019;codon 45-111; HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain 216596028354 HMMPfam:PF02518;Histidine kinase-, DNA gyrase B-,and HSP90;1e-35;codon 151-273; HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90 216596028355 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 216596028356 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596028357 active site 216596028358 phosphorylation site [posttranslational modification] 216596028359 intermolecular recognition site; other site 216596028360 dimerization interface [polypeptide binding]; other site 216596028361 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216596028362 DNA binding site [nucleotide binding] 216596028363 HMMPfam:PF00072;Response regulator receiver domain;3.3e-38;codon 7-126; HMMPfam hit to PF00072, Response regulator receiver domain 216596028364 HMMPfam:PF00486;Transcriptional regulatory protein, C te;1.8e-14;codon 158-233; HMMPfam hit to PF00486, Transcriptional regulatory protein, C te 216596028365 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 216596028366 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 216596028367 HMMPfam:PF01609;Transposase DDE domain;0.012;codon 73-219; HMMPfam hit to PF01609, Transposase DDE domain 216596028368 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 216596028369 Transposase domain (DUF772); Region: DUF772; pfam05598 216596028370 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 216596028371 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 216596028372 HMMPfam:PF01609;Transposase DDE domain;0.00094;codon 287-435; HMMPfam hit to PF01609, Transposase DDE domain 216596028373 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 216596028374 HMMPfam:PF01609;Transposase DDE domain;0.00067;codon 1-154; HMMPfam hit to PF01609, Transposase DDE domain 216596028375 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 216596028376 pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188 216596028377 Int/Topo IB signature motif; other site 216596028378 HMMPfam:PF00589;Phage integrase family;6.2e-08;codon 227-397; HMMPfam hit to PF00589, Phage integrase family 216596028379 HMMPfam:PF02899;Phage integrase, N-terminal SAM-like;0.00094;codon 120-203; HMMPfam hit to PF02899, Phage integrase, N-terminal SAM-like 216596028380 HMMPfam:PF02899;Phage integrase, N-terminal SAM-like;0.14;codon 24-104; HMMPfam hit to PF02899, Phage integrase, N-terminal SAM-like 216596028381 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 216596028382 Integrase core domain; Region: rve; pfam00665 216596028383 DDE domain; Region: DDE_Tnp_IS240; pfam13610 216596028384 HMMPfam:PF00665;Integrase core domain;9.3e-09;codon 76-224; HMMPfam hit to PF00665, Integrase core domain 216596028385 conjugal transfer protein TraD; Provisional; Region: PRK13847 216596028386 HMMPfam:PF06412;Conjugal transfer protein TraD;9.9e-39;codon 5-71; HMMPfam hit to PF06412, Conjugal transfer protein TraD 216596028387 conjugal transfer protein TraC; Provisional; Region: PRK13848 216596028388 HMMPfam:PF07820;TraC-like protein;1.5e-43;codon 2-97; HMMPfam hit to PF07820, TraC-like protein 216596028389 Dtr system oriT relaxase; Provisional; Region: PRK13826 216596028390 MobA/MobL family; Region: MobA_MobL; pfam03389 216596028391 AAA domain; Region: AAA_30; pfam13604 216596028392 Family description; Region: UvrD_C_2; pfam13538 216596028393 HMMPfam:PF03389;MobA/MobL family;3.3e-136;codon 17-243; HMMPfam hit to PF03389, MobA/MobL family 216596028394 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 216596028395 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 216596028396 1 probable transmembrane helix predicted at aa 17-39 216596028397 conjugal transfer protein TraB; Provisional; Region: PRK13825 216596028398 active site 216596028399 catalytic triad [active] 216596028400 dimer interface [polypeptide binding]; other site 216596028401 HMMPfam:PF07186;TraB protein;7.9e-246;codon 3-387; HMMPfam hit to PF07186, TraB protein 216596028402 5 probable transmembrane helices predicted at aa 12-34, 76-98, 107-129, 133-155 and 162-179 216596028403 conjugal transfer protein TraH; Provisional; Region: PRK13843 216596028404 HMMPfam:PF06871;TraH_2;1.1e-136;codon 1-204; HMMPfam hit to PF06871, TraH_2 216596028405 1 probable transmembrane helix predicted at aa 21-43 216596028406 putative autoinducer synthesis protein; Provisional; Region: PRK13834 216596028407 HMMPfam:PF00765;Autoinducer synthetase;4.4e-65;codon 37-219; HMMPfam hit to PF00765, Autoinducer synthetase 216596028408 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 216596028409 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 216596028410 P-loop; other site 216596028411 Magnesium ion binding site [ion binding]; other site 216596028412 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 216596028413 Magnesium ion binding site [ion binding]; other site 216596028414 HMMPfam:PF01656;CobQ/CobB/MinD/ParA nucleotide binding domai;1.6e-47;codon 138-372; HMMPfam hit to PF01656, CobQ/CobB/MinD/ParA nucleotide binding domai 216596028415 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 216596028416 ParB-like nuclease domain; Region: ParBc; pfam02195 216596028417 HMMPfam:PF02195;ParB-like nuclease domain;5.6e-20;codon 56-147; HMMPfam hit to PF02195, ParB-like nuclease domain 216596028418 HMMPfam:PF07506;RepB plasmid partitioning protein;1.5e-27;codon 148-321; HMMPfam hit to PF07506, RepB plasmid partitioning protein 216596028419 replication initiation protein RepC; Provisional; Region: PRK13824 216596028420 Replication protein C N-terminal domain; Region: RP-C; pfam03428 216596028421 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 216596028422 HMMPfam:PF03428;Replication protein C;4.7e-231;codon 2-409; HMMPfam hit to PF03428, Replication protein C 216596028423 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 216596028424 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 216596028425 catalytic residues [active] 216596028426 catalytic nucleophile [active] 216596028427 Presynaptic Site I dimer interface [polypeptide binding]; other site 216596028428 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 216596028429 Synaptic Flat tetramer interface [polypeptide binding]; other site 216596028430 Synaptic Site I dimer interface [polypeptide binding]; other site 216596028431 DNA binding site [nucleotide binding] 216596028432 HMMPfam:PF00239;Resolvase, N terminal domain;3.2e-58;codon 25-159; HMMPfam hit to PF00239, Resolvase, N terminal domain 216596028433 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 216596028434 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 216596028435 Putative transposase; Region: Y2_Tnp; pfam04986 216596028436 HMMPfam:PF04986;Putative transposase;4.5e-94;codon 143-333; HMMPfam hit to PF04986, Putative transposase 216596028437 integron integrase; Region: integrase_gron; TIGR02249 216596028438 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 216596028439 Int/Topo IB signature motif; other site 216596028440 HMMPfam:PF00589;Phage integrase family;2.7e-34;codon 118-283; HMMPfam hit to PF00589, Phage integrase family 216596028441 HMMPfam:PF02899;Phage integrase, N-terminal SAM-like;2.3e-10;codon 20-100; HMMPfam hit to PF02899, Phage integrase, N-terminal SAM-like 216596028442 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 216596028443 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 216596028444 Zeta toxin; Region: Zeta_toxin; pfam06414 216596028445 HMMPfam:PF06414;Zeta toxin;1.3e-05;codon 22-231; HMMPfam hit to PF06414, Zeta toxin 216596028446 HMMPfam:PF02902;Ulp1 protease family, C-terminal cataly;0.00017;codon 674-873; HMMPfam hit to PF02902, Ulp1 protease family,C-terminal cataly 216596028447 1 probable transmembrane helix predicted at aa 13-35 216596028448 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 216596028449 DNA-binding interface [nucleotide binding]; DNA binding site 216596028450 HMMPfam:PF01527;Transposase;2.2e-31;codon 3-80; HMMPfam hit to PF01527, Transposase 216596028451 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 216596028452 HTH-like domain; Region: HTH_21; pfam13276 216596028453 Integrase core domain; Region: rve; pfam00665 216596028454 Integrase core domain; Region: rve_3; pfam13683 216596028455 HMMPfam:PF00665;Integrase core domain;6.3e-41;codon 112-270; HMMPfam hit to PF00665, Integrase core domain 216596028456 Similar to codons 280 to the C-terminus of Pseudomonas fluorescens TnpC protein. UniProt:Q70MR9_PSEFL (EMBL:PFL563381) (501 aa), and to Agrobacterium tumefaciens hypothetical protein. UniProt:Q44432_9RHIZ (EMBL:ATPINF) (206 aa). Frameshift after codon 70; similarity:fasta; with=UniProt:Q70MR9_PSEFL (EMBL:PFL563381); Pseudomonas fluorescens.; TnpC protein.; length=501; id 27.442; 215 aa overlap; query 2-154; subject 279-492; similarity:fasta; with=UniProt:Q44432_9RHIZ (EMBL:ATPINF); Agrobacterium tumefaciens.; Hypothetical protein.; length=206; id 80.220; 91 aa overlap; query 62-152; subject 110-200 216596028457 putative transposase, pseudogene; Codons 90 to the C-terminus are similar to codons 260 to the C-terminus of Rhizobium meliloti (Sinorhizobium meliloti) putative transposase for insertion sequence isrm18. UniProt:Q925Y7_RHIME (EMBL:SME591792) (507 aa); similarity:fasta; with=UniProt:Q925Y7_RHIME (EMBL:SME591792); Rhizobium meliloti (Sinorhizobium meliloti).; PUTATIVE TRANSPOSASE FOR INSERTION SEQUENCE ISRM18.; length=507; id 80.784; 255 aa overlap; query 90-343; subject 261-507 216596028458 putative transposase, pseudogene; N-terminus to codon 170 is similar to N-terminus to codon 180 of Rhizobium leguminosarum transposase. UniProt:P72290_RHILE (EMBL:RLRMS) (202 aa); similarity:fasta; with=UniProt:P72290_RHILE (EMBL:RLRMS); Rhizobium leguminosarum.; Transposase.; length=202; id 90.303; 165 aa overlap; query 1-165; subject 14-178 216596028459 type IV secretion system T-DNA border endonuclease VirD2; Provisional; Region: PRK13863 216596028460 type IV secretion system T-DNA border endonuclease VirD1; Provisional; Region: PRK13858 216596028461 HMMPfam:PF07328;T-DNA border endonuclease VirD1;1.6e-34;codon 13-163; HMMPfam hit to PF07328, T-DNA border endonuclease VirD1 216596028462 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 216596028463 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 216596028464 P-loop; other site 216596028465 Magnesium ion binding site [ion binding]; other site 216596028466 HMMPfam:PF07015;VirC1 protein;1.2e-105;codon 51-241; HMMPfam hit to PF07015, VirC1 protein 216596028467 putative crown gall tumor protein VirC2; Provisional; Region: PRK13862 216596028468 HMMPfam:PF07181;VirC2 protein;3.8e-44;codon 1-195; HMMPfam hit to PF07181, VirC2 protein 216596028469 Similar to Escherichia coli probable transposase for transposon tn903. UniProt:TRA2_ECOLI (EMBL:TT903A3) (307 aa),and to Anabaena sp. (strain PCC 7120) transposase. UniProt:Q8YV29_ANASP (EMBL:BA000019) (279 aa); similarity:fasta; with=UniProt:TRA2_ECOLI (EMBL:TT903A3); Escherichia coli.; Probable transposase for transposon Tn903.; length=307; id 34.615; 104 aa overlap; query 24-126; subject 181-281; similarity:fasta; with=UniProt:Q8YV29_ANASP (EMBL:BA000019); Anabaena sp. (strain PCC 7120).; Transposase.; length=279; id 38.393; 112 aa overlap; query 17-126; subject 146-252; putative transposase, pseudogene 216596028470 Transposase, Mutator family; Region: Transposase_mut; pfam00872 216596028471 MULE transposase domain; Region: MULE; pfam10551 216596028472 HMMPfam:PF00872;Transposase, Mutator family;1.3e-159;codon 1-358; HMMPfam hit to PF00872, Transposase, Mutator family 216596028473 DDE domain; Region: DDE_Tnp_IS240; pfam13610 216596028474 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 216596028475 HMMPfam:PF05016;Plasmid stabilisation system protein;2.4e-18;codon 9-96; HMMPfam hit to PF05016, Plasmid stabilisation system protein 216596028476 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 216596028477 Integrase core domain; Region: rve; pfam00665 216596028478 HMMPfam:PF00665;Integrase core domain;1.3e-08;codon 69-217; HMMPfam hit to PF00665, Integrase core domain 216596028479 Codons 25 to the C-terminus are similar to codons 252 to the C-terminus of Caulobacter crescentus is511,transposase OrfB (caulobacter crescentus insertion sequence is511 orfa and orfb genes, complete cds). UniProt:Q7DB06_CAUCR (EMBL:CC39501) (308 aa), and to Rhizobium etli yi04c-ii hypothetical protein yi04c-ii. UniProt:Q8KKP7_RHIET (EMBL:U80928) (208 aa); similarity:fasta; with=UniProt:Q7DB06_CAUCR (EMBL:CC39501); Caulobacter crescentus.; IS511,transposase OrfB (Caulobacter crescentus insertion sequence IS511 OrfA and OrfB genes, complete cds).; length=308; id 59.322; 59 aa overlap; query 24-82; subject 251-308; similarity:fasta; with=UniProt:Q8KKP7_RHIET (EMBL:U80928); Rhizobium etli.; yi04c-II; Hypothetical protein yi04c-II.; length=208; id 88.136; 59 aa overlap; query 24-82; subject 150-208; putative transposase, pseudogene 216596028480 Similar to Thiobacillus ferrooxidans transposase for insertion sequence element ist2. UniProt:TRA2_THIFE (EMBL:TFIST2) (296 aa), and to Rhizobium loti (Mesorhizobium loti) transposase. UniProt:Q989U4_RHILO (EMBL:BA000012) (180 aa); similarity:fasta; with=UniProt:TRA2_THIFE (EMBL:TFIST2); Thiobacillus ferrooxidans.; Transposase for insertion sequence element IST2.; length=296; id 48.571; 70 aa overlap; query 43-104; subject 179-245; similarity:fasta; with=UniProt:Q989U4_RHILO (EMBL:BA000012); Rhizobium loti (Mesorhizobium loti).; Transposase.; length=180; id 67.188; 64 aa overlap; query 46-109; subject 116-179; putative transposase for insertion sequence element, pseudogene 216596028481 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 216596028482 Integrase core domain; Region: rve; pfam00665 216596028483 HMMPfam:PF00665;Integrase core domain;1.3e-08;codon 69-217; HMMPfam hit to PF00665, Integrase core domain 216596028484 Codons 30 to 85 are similar to codons 255 to the C-terminus of Sphingomonas sp IS element-like sequence. UniProt:Q9X9R1_9SPHN (EMBL:SSU65001) (308 aa), and codons 30 to the C-terminus are similar to codons 255 to 350 of Rhizobium etli yi07 putative insertion sequence ATP-binding protein. UniProt:Q8KLC8_RHIET (EMBL:U80928) (689 aa); similarity:fasta; with=UniProt:Q9X9R1_9SPHN (EMBL:SSU65001); Sphingomonas sp.; IS element-like sequence.; length=308; id 49.057; 53 aa overlap; query 32-84; subject 256-308; similarity:fasta; with=UniProt:Q8KLC8_RHIET (EMBL:U80928); Rhizobium etli.; yi07; Putative insertion sequence ATP-binding protein.; length=689; id 47.253; 91 aa overlap; query 32-122; subject 256-345; putative IS element-like sequence, pseudogene 216596028485 conserved hypothetical protein, pseudogene; Similar to codons 25 to 110 of Rhizobium etli yp022 hypothetical protein yp022. UniProt:Q8KL84_RHIET (EMBL:U80928) (152 aa); similarity:fasta; with=UniProt:Q8KL84_RHIET (EMBL:U80928); Rhizobium etli.; yp022; Hypothetical protein yp022.; length=152; id 42.353; 85 aa overlap; query 1-85; subject 24-108 216596028486 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 216596028487 Integrase core domain; Region: rve; pfam00665 216596028488 HMMPfam:PF00665;Integrase core domain;1.3e-08;codon 69-217; HMMPfam hit to PF00665, Integrase core domain 216596028489 AAA-like domain; Region: AAA_10; pfam12846 216596028490 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 216596028491 Walker A motif; other site 216596028492 ATP binding site [chemical binding]; other site 216596028493 Walker B motif; other site 216596028494 HMMPfam:PF02534;TraG/TraD family;4.3e-135;codon 91-492; HMMPfam hit to PF02534, TraG/TraD family 216596028495 2 probable transmembrane helices predicted at aa 4-26 and 57-79 216596028496 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 216596028497 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 216596028498 P-loop; other site 216596028499 Magnesium ion binding site [ion binding]; other site 216596028500 HMMPfam:PF07015;VirC1 protein;5.4e-101;codon 40-230; HMMPfam hit to PF07015, VirC1 protein 216596028501 DDE domain; Region: DDE_Tnp_IS240; pfam13610 216596028502 Transposase; Region: DEDD_Tnp_IS110; pfam01548 216596028503 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 216596028504 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 216596028505 HMMPfam:PF02371;Transposase IS116/IS110/IS902 family;7.5e-19;codon 190-298; HMMPfam hit to PF02371, Transposase IS116/IS110/IS902 family 216596028506 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 216596028507 Transposase; Region: DEDD_Tnp_IS110; pfam01548 216596028508 Similar to Sphingomonas sp. P2 orf26 putative transposase. UniProt:Q83VJ0_9SPHN (EMBL:AB091693) (347 aa), and to Rhizobium loti (Mesorhizobium loti) transposase. UniProt:Q98A82_RHILO (347 aa); similarity:fasta; with=UniProt:Q83VJ0_9SPHN (EMBL:AB091693); Sphingomonas sp. P2.; orf26; Putative transposase.; length=347; id 68.027; 147 aa overlap; query 1-147; subject 201-346; similarity:fasta; with=UniProt:Q98A82_RHILO; Rhizobium loti (Mesorhizobium loti).; Transposase.; length=347; id 72.109; 147 aa overlap; query 1-147; subject 201-347 216596028509 HMMPfam:PF02371;Transposase IS116/IS110/IS902 family;3.2e-16;codon 1-99; HMMPfam hit to PF02371, Transposase IS116/IS110/IS902 family 216596028510 Codon 1 to 110 is similar to codons 75 to 190 of Enterococcus faecalis TnpA SWALL:Q83Z93_ENTFA (SWALL:Q83Z93) (228 aa), and codon 1 to the C-terminus is similar to codons 85 to the C-terminus of Rhizobium loti transposase SWALL:Q981F5_RHILO (SWALL:Q981F5) (243 aa); similarity:fasta; SWALL:Q83Z93_ENTFA (SWALL:Q83Z93); Enterococcus faecalis; TnpA; length 228 aa; 114 aa overlap; query 1-108 aa; subject 75-188 aa; similarity:fasta; SWALL:Q981F5_RHILO (SWALL:Q981F5); Rhizobium loti; transposase; length 243 aa; 159 aa overlap; query 1-157 aa; subject 85-243 aa; putative transposase, pseudogene 216596028511 DDE superfamily endonuclease; Region: DDE_3; pfam13358 216596028512 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 216596028513 additional locus_tag pRL70147; conserved hypothetical protein, pseudogene; similarity:fasta; with=UniProt:Y4PG_RHISN (EMBL:RSAE95); Rhizobium sp. (strain NGR234).; Hypothetical 21.1 kDa protein y4pG/y4sC.; length=192; id 76.316; 190 aa overlap; query 1-190; subject 1-190; This CDS has been interrupted by the insertion of a repetitive insertion element after codon 51 216596028514 Transposase; Region: HTH_Tnp_1; pfam01527 216596028515 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 216596028516 HMMPfam:PF01527;Transposase;2.6e-14;codon 17-91; HMMPfam hit to PF01527, Transposase 216596028517 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 216596028518 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 216596028519 HMMPfam:PF05717;IS66 Orf2 like protein;3.9e-63;codon 4-113; HMMPfam hit to PF05717, IS66 Orf2 like protein 216596028520 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 216596028521 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 216596028522 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 216596028523 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 216596028524 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 216596028525 HMMPfam:PF03050;Transposase IS66 family;9.2e-112;codon 143-346; HMMPfam hit to PF03050, Transposase IS66 family 216596028526 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 216596028527 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 216596028528 N-acetyl-D-glucosamine binding site [chemical binding]; other site 216596028529 catalytic residue [active] 216596028530 HMMPfam:PF01464;Transglycosylase SLT domain;6.3e-22;codon 146-255; HMMPfam hit to PF01464, Transglycosylase SLT domain 216596028531 TrbC/VIRB2 family; Region: TrbC; pfam04956 216596028532 HMMPfam:PF06921;VIRB2 type IV secretion protein;1.5e-07;codon 9-103; HMMPfam hit to PF06921, VIRB2 type IV secretion protein 216596028533 3 probable transmembrane helices predicted at aa 13-34, 49-71 and 78-100 216596028534 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 216596028535 HMMPfam:PF05101;Type IV secretory pathway,VirB3-like protei;0.00038;codon 5-92; HMMPfam hit to PF05101, Type IV secretory pathway,VirB3-like protei 216596028536 2 probable transmembrane helices predicted at aa 15-37 and 42-60 216596028537 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 216596028538 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 216596028539 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 216596028540 HMMPfam:PF03135;CagE, TrbE, VirB family,component of;8.3e-31;codon 181-389; HMMPfam hit to PF03135, CagE, TrbE, VirB family,component of 216596028541 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 216596028542 HMMPfam:PF04610;TrbL/VirB6 plasmid conjugal transfer protein;3.1e-06;codon 42-302; HMMPfam hit to PF04610, TrbL/VirB6 plasmid conjugal transfer protein 216596028543 6 probable transmembrane helices predicted at aa 44-63, 73-95, 173-195, 199-218,227-249 and 269-286 216596028544 VirB8 protein; Region: VirB8; pfam04335 216596028545 1 probable transmembrane helix predicted at aa 48-70 216596028546 HMMPfam:PF04335;VirB8 protein;1.3e-30;codon 63-239; HMMPfam hit to PF04335, VirB8 protein 216596028547 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 216596028548 VirB7 interaction site; other site 216596028549 HMMPfam:PF03524;Conjugal transfer protein;5.9e-37;codon 44-249; HMMPfam hit to PF03524, Conjugal transfer protein 216596028550 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 216596028551 1 probable transmembrane helix predicted at aa 51-73 216596028552 HMMPfam:PF03743;Bacterial conjugation TrbI-like protein;4.7e-56;codon 273-457; HMMPfam hit to PF03743, Bacterial conjugation TrbI-like protein 216596028553 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 216596028554 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 216596028555 Walker A motif; other site 216596028556 hexamer interface [polypeptide binding]; other site 216596028557 ATP binding site [chemical binding]; other site 216596028558 Walker B motif; other site 216596028559 HMMPfam:PF00437;Type II/IV secretion system protein;2.3e-59;codon 6-317; HMMPfam hit to PF00437, Type II/IV secretion system protein 216596028560 putative transposase, pseudogene; Similar to C-terminus from codon 50 of Photobacterium profundum (Photobacterium sp. (strain SS9)) all2152 hypothetical transposase. UniProt:Q6LKS7_PHOPR (EMBL:CR378675) (114 aa); similarity:fasta; with=UniProt:Q6LKS7_PHOPR (EMBL:CR378675); Photobacterium profundum (Photobacterium sp. (strain SS9)).; ALL2152; Hypothetical transposase.; length=114; id 50.000; 60 aa overlap; query 3-62; subject 53-112 216596028561 Transposase; Region: HTH_Tnp_1; cl17663 216596028562 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 216596028563 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 216596028564 HMMPfam:PF05717;IS66 Orf2 like protein;3.4e-48;codon 2-100; HMMPfam hit to PF05717, IS66 Orf2 like protein 216596028565 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 216596028566 Similar to Pseudomonas fluorescens tnpc tnpc protein. UniProt:Q70MR9_PSEFL (EMBL:PFL563381) (501 aa), and to Rhizobium sp. (strain NGR234) hypothetical 61.7 kda protein y4hp. UniProt:Y4HP_RHISN (EMBL:RSPLAS) (552 aa); similarity:fasta; with=UniProt:Q70MR9_PSEFL (EMBL:PFL563381); Pseudomonas fluorescens.; TnpC protein.; length=501; id 47.518; 282 aa overlap; query 18-296; subject 83-347; similarity:fasta; with=UniProt:Y4HP_RHISN (EMBL:RSPLAS); Rhizobium sp. (strain NGR234).; Hypothetical 61.7 kDa protein y4hP.; length=552; id 62.333; 300 aa overlap; query 2-297; subject 102-398; putative transposase protein, pseudogene 216596028567 HMMPfam:PF03050;Transposase IS66 family;1.4e-113;codon 46-246; HMMPfam hit to PF03050, Transposase IS66 family 216596028568 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 216596028569 Integrase core domain; Region: rve; pfam00665 216596028570 HMMPfam:PF00665;Integrase core domain;1.3e-08;codon 69-217; HMMPfam hit to PF00665, Integrase core domain 216596028571 Similar to N-terminus to codon 170 of Salmonella typhimurium TnpA transposase (fragment). UniProt:Q5CCH5_SALTY (EMBL:STY9820) (244 aa), and similar, but truncated at the N-terminus, to Rhizobium leguminosarum transposase. UniProt:P72290_RHILE (EMBL:RLRMS) (202 aa); similarity:fasta; with=UniProt:Q5CCH5_SALTY (EMBL:STY9820); Salmonella typhimurium.; tnpA; Transposase (Fragment).; length=244; id 50.307; 163 aa overlap; query 17-177; subject 3-165; similarity:fasta; with=UniProt:P72290_RHILE (EMBL:RLRMS); Rhizobium leguminosarum.; Transposase.; length=202; id 88.485; 165 aa overlap; query 1-165; subject 14-178 216596028572 Predicted transcriptional regulator [Transcription]; Region: COG4190 216596028573 putative transposase OrfB; Reviewed; Region: PHA02517 216596028574 HTH-like domain; Region: HTH_21; pfam13276 216596028575 Integrase core domain; Region: rve; pfam00665 216596028576 Integrase core domain; Region: rve_3; pfam13683 216596028577 HMMPfam:PF00665;Integrase core domain;4.2e-35;codon 109-266; HMMPfam hit to PF00665, Integrase core domain 216596028578 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 216596028579 Transposase; Region: HTH_Tnp_1; cl17663 216596028580 Integrase core domain; Region: rve_3; cl15866 216596028581 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 216596028582 HMMPfam:PF02643;Uncharacterized ACR,COG1430;7.3e-16;codon 77-192; HMMPfam hit to PF02643, Uncharacterized ACR,COG1430 216596028583 Similar to Escherichia coli probable transposase for transposon tn903. UniProt:TRA2_ECOLI (EMBL:TT903A3) (307 aa),and to Anabaena sp. (strain PCC 7120) transposase. UniProt:Q8YV29_ANASP (279 aa); similarity:fasta; with=UniProt:TRA2_ECOLI (EMBL:TT903A3); Escherichia coli.; Probable transposase for transposon Tn903.; length=307; id 31.897; 116 aa overlap; query 5-119; subject 194-305; similarity:fasta; with=UniProt:Q8YV29_ANASP; Anabaena sp. (strain PCC 7120).; Transposase.; length=279; id 41.026; 117 aa overlap; query 5-119; subject 162-276 216596028584 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 216596028585 Integrase core domain; Region: rve; pfam00665 216596028586 HMMPfam:PF00665;Integrase core domain;2e-07;codon 76-224; HMMPfam hit to PF00665, Integrase core domain 216596028587 Similar to C-terminus from codon 60 of Agrobacterium tumefaciens Ti plasmid pti15955 t-DNA region. UniProt:Q44393_9RHIZ (EMBL:ATACH5) (104 aa), and similar to the C-terminus from codon 490 of Rhizobium etli hypothetical protein yi14b-iii (hypothetical protein yi14c-iii). UniProt:Q8KI12_RHIET (EMBL:U80928) (530 aa); similarity:fasta; with=UniProt:Q44393_9RHIZ (EMBL:ATACH5); Agrobacterium tumefaciens.; Ti plasmid pTi15955 T-DNA region.; length=104; id 41.026; 39 aa overlap; query 18-56; subject 57-94; similarity:fasta; with=UniProt:Q8KI12_RHIET (EMBL:U80928); Rhizobium etli.; yi14b-III; Hypothetical protein yi14b-III (Hypothetical protein yi14c-III).; length=530; id 77.500; 40 aa overlap; query 18-57; subject 490-529 216596028588 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 216596028589 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 216596028590 P-loop; other site 216596028591 Magnesium ion binding site [ion binding]; other site 216596028592 HMMPfam:PF07015;VirC1 protein;5.4e-101;codon 40-230; HMMPfam hit to PF07015, VirC1 protein 216596028593 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 216596028594 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 216596028595 Integrase core domain; Region: rve; pfam00665 216596028596 HMMPfam:PF00665;Integrase core domain;1.5e-07;codon 76-224; HMMPfam hit to PF00665, Integrase core domain 216596028597 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 216596028598 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 216596028599 Integrase core domain; Region: rve; pfam00665 216596028600 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 216596028601 Transposase; Region: HTH_Tnp_1; cl17663 216596028602 putative transposase OrfB; Reviewed; Region: PHA02517 216596028603 HTH-like domain; Region: HTH_21; pfam13276 216596028604 Integrase core domain; Region: rve; pfam00665 216596028605 Integrase core domain; Region: rve_3; pfam13683 216596028606 HMMPfam:PF00665;Integrase core domain;4.2e-35;codon 109-266; HMMPfam hit to PF00665, Integrase core domain 216596028607 putative transposase, pseudogene; Codons 48 to the C-terminus are similar to codons 210 to the C-terminus of Rhizobium hedysari putative transposase. UniProt:O30982_RHIHE (EMBL:AF023675) (250 aa); similarity:fasta; with=UniProt:O30982_RHIHE (EMBL:AF023675); Rhizobium hedysari.; Putative transposase.; length=250; id 66.667; 42 aa overlap; query 48-88; subject 209-250 216596028608 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 216596028609 Uncharacterized conserved protein [Function unknown]; Region: COG5361 216596028610 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 216596028611 HMMPfam:PF06742;Protein of unknown function (DUF1214);1.8e-34;codon 231-337; HMMPfam hit to PF06742, Protein of unknown function (DUF1214) 216596028612 Uncharacterized conserved protein [Function unknown]; Region: COG5361 216596028613 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 216596028614 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 216596028615 HMMPfam:PF06742;Protein of unknown function (DUF1214);1.8e-58;codon 341-462; HMMPfam hit to PF06742, Protein of unknown function (DUF1214) 216596028616 HMMPfam:PF06863;Protein of unknown function (DUF1254);6.8e-53;codon 36-158; HMMPfam hit to PF06863, Protein of unknown function (DUF1254) 216596028617 N-terminus to codon 73 is similar to codons 35 to 105 of Rhizobium etli putative integrase IntA (fragment). UniProt:Q84HQ3_RHIET (EMBL:AF538365) (195 aa), and N-terminus to codon 75 is similar to codon 45 to 120 of Agrobacterium tumefaciens (strain C58/ATCC 33970) agr_pat_22p. UniProt:Q7D440_AGRT5 (EMBL:AE007874) (426 aa); similarity:fasta; with=UniProt:Q84HQ3_RHIET (EMBL:AF538365); Rhizobium etli.; intA; Putative integrase IntA (Fragment).; length=195; id 76.056; 71 aa overlap; query 1-71; subject 35-105; similarity:fasta; with=UniProt:Q7D440_AGRT5 (EMBL:AE007874); Agrobacterium tumefaciens (strain C58/ATCC 33970).; AGR_pAT_22p.; length=426; id 93.056; 72 aa overlap; query 1-72; subject 45-116 216596028618 Codons 25 to the C-terminus are similar to codons 160 to the C-terminus of Selenomonas ruminantium XerD integrase/recombinase homolog. UniProt:XERD_SELRU (EMBL:AB011029) (341 aa), and similar to the C-terminus from codon 135 of Agrobacterium tumefaciens (strain C58/ATCC 33970) IntX phage-related integrase. UniProt:Q8UKT4_AGRT5 (EMBL:AE008927) (346 aa). Frameshift after codon 75; similarity:fasta; with=UniProt:XERD_SELRU (EMBL:AB011029); Selenomonas ruminantium.; xerD; Integrase/recombinase xerD homolog.; length=341; id 32.558; 172 aa overlap; query 28-196; subject 160-323; similarity:fasta; with=UniProt:Q8UKT4_AGRT5 (EMBL:AE008927); Agrobacterium tumefaciens (strain C58/ATCC 33970).; intX; Phage-related integrase.; length=346; id 84.360; 211 aa overlap; query 1-211; subject 136-346; putative integrase/recombinase, pseudogene 216596028619 HMMPfam:PF00589;Phage integrase family;1.8e-10;codon 13-207; HMMPfam hit to PF00589, Phage integrase family 216596028620 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 216596028621 MerR family regulatory protein; Region: MerR; pfam00376 216596028622 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 216596028623 P-loop; other site 216596028624 Magnesium ion binding site [ion binding]; other site 216596028625 Pfam match to entry PF00376.9 MerR 216596028626 Pfam match to entry PF01656.8 CbiA 216596028627 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 216596028628 ParB-like nuclease domain; Region: ParB; smart00470 216596028629 Pfam match to entry PF02195.5 ParBc 216596028630 Pfam match to entry PF07506.1 RepB 216596028631 replication initiation protein RepC; Provisional; Region: PRK13824 216596028632 Replication protein C N-terminal domain; Region: RP-C; pfam03428 216596028633 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 216596028634 Pfam match to entry PF03428.3 RP-C 216596028635 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216596028636 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 216596028637 Walker A/P-loop; other site 216596028638 ATP binding site [chemical binding]; other site 216596028639 ABC transporter signature motif; other site 216596028640 Walker B; other site 216596028641 D-loop; other site 216596028642 H-loop/switch region; other site 216596028643 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 216596028644 DNA binding site [nucleotide binding] 216596028645 dimer interface [polypeptide binding]; other site 216596028646 active site 216596028647 Int/Topo IB signature motif; other site 216596028648 Pfam match to entry PF00589.8 Phage_integrase 216596028649 Protein of unknown function (DUF1612); Region: DUF1612; pfam07756 216596028650 HTH DNA binding domain; Region: HTH_13; pfam11972 216596028651 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 216596028652 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 216596028653 ATPase family associated with various cellular activities (AAA); Region: AAA; pfam00004 216596028654 Pfam match to entry PF00004.13 AAA 216596028655 Predicted helix-turn-helix motif with score 1861.000, SD 5.53 at aa 347-368, sequence IGGADTARILGVSRQAIYAYLK 216596028656 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 216596028657 active site 216596028658 catalytic triad [active] 216596028659 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 216596028660 2 probable transmembrane helices predicted at aa 95-112 and 117-139 216596028661 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 216596028662 conserved cys residue [active] 216596028663 Pfam match to entry PF00165.8 HTH_AraC 216596028664 Pfam match to entry PF00165.8 HTH_AraC 216596028665 Predicted helix-turn-helix motif with score 1238.000, SD 3.40 at aa 235-256, sequence FSLDVAADALHVSKRTLQRRME 216596028666 submitted without /pseudo; similarity:fasta; SWALL:Q82S47 (EMBL:BX321864); Nitrosomonas europaea; hypothetical protein; ne2512; length 100 aa; 97 aa overlap; query 1-92 aa; subject 1-97 aa; similarity:fasta; SWALL:Q82QR3 (EMBL:AP005022); Streptomyces avermitilis; hypothetical protein; sav442; length 101 aa; 96 aa overlap; query 2-92 aa; subject 4-99 aa 216596028667 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 216596028668 substrate binding site [chemical binding]; other site 216596028669 Pfam match to entry PF01161.9 PBP 216596028670 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 216596028671 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 216596028672 Pfam match to entry PF03640.4 Lipoprotein_15 216596028673 Pfam match to entry PF03640.4 Lipoprotein_15 216596028674 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 216596028675 putative hydrophobic ligand binding site [chemical binding]; other site 216596028676 Pfam match to entry PF06240.1 COXG 216596028677 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 216596028678 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 216596028679 Pfam match to entry PF00561.8 Abhydrolase_1 216596028680 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 216596028681 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 216596028682 Pfam match to entry PF00941.7 FAD_binding_5 216596028683 Pfam match to entry PF03450.3 CO_deh_flav_C 216596028684 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 216596028685 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 216596028686 catalytic loop [active] 216596028687 iron binding site [ion binding]; other site 216596028688 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 216596028689 Pfam match to entry PF00111.12 Fer2 216596028690 Pfam match to entry PF01799.6 Fer2_2 216596028691 4-hydroxybenzoyl-CoA reductase, alpha subunit; Region: 4hydrxCoA_A; TIGR03194 216596028692 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 216596028693 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 216596028694 Pfam match to entry PF01315.9 Ald_Xan_dh_C 216596028695 Pfam match to entry PF02738.5 Ald_Xan_dh_C2 216596028696 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 216596028697 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_5; cd06338 216596028698 putative ligand binding site [chemical binding]; other site 216596028699 Pfam match to entry PF01094.13 ANF_receptor 216596028700 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 216596028701 TM-ABC transporter signature motif; other site 216596028702 Pfam match to entry PF02653.5 BPD_transp_2 216596028703 8 probable transmembrane helices predicted at aa 15-37, 42-61, 66-88, 100-122,144-166, 198-220, 235-257 and 262-284 216596028704 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 216596028705 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 216596028706 TM-ABC transporter signature motif; other site 216596028707 9 probable transmembrane helices predicted at aa 5-22, 32-51, 58-80, 84-106,113-135, 155-177, 210-232, 247-269 and 282-304 216596028708 Pfam match to entry PF02653.5 BPD_transp_2 216596028709 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 216596028710 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 216596028711 Walker A/P-loop; other site 216596028712 ATP binding site [chemical binding]; other site 216596028713 Q-loop/lid; other site 216596028714 ABC transporter signature motif; other site 216596028715 Walker B; other site 216596028716 D-loop; other site 216596028717 H-loop/switch region; other site 216596028718 Pfam match to entry PF00005.11 ABC_tran 216596028719 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 216596028720 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 216596028721 Walker A/P-loop; other site 216596028722 ATP binding site [chemical binding]; other site 216596028723 Q-loop/lid; other site 216596028724 ABC transporter signature motif; other site 216596028725 Walker B; other site 216596028726 D-loop; other site 216596028727 H-loop/switch region; other site 216596028728 Pfam match to entry PF00005.11 ABC_tran 216596028729 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 216596028730 HAMP domain; Region: HAMP; pfam00672 216596028731 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 216596028732 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 216596028733 dimer interface [polypeptide binding]; other site 216596028734 putative CheW interface [polypeptide binding]; other site 216596028735 1 probable transmembrane helix predicted at aa 187-209 216596028736 Pfam match to entry PF00672.10 HAMP 216596028737 Pfam match to entry PF00015.9 MCPsignal 216596028738 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596028739 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596028740 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216596028741 dimerization interface [polypeptide binding]; other site 216596028742 Pfam match to entry PF03466.5 LysR_substrate 216596028743 Pfam match to entry PF00126.10 HTH_1 216596028744 Predicted helix-turn-helix motif with score 1461.000, SD 4.16 at aa 16-37, sequence GNFTRASEVLNIAQPALSRQIR 216596028745 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 216596028746 Ligand binding site; other site 216596028747 metal-binding site 216596028748 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 216596028749 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 216596028750 FeS/SAM binding site; other site 216596028751 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 216596028752 Pfam match to entry PF06463.1 Mob_synth_C 216596028753 Pfam match to entry PF04055.5 Radical_SAM 216596028754 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216596028755 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216596028756 Pfam match to entry PF00440.8 TetR_N 216596028757 Predicted helix-turn-helix motif with score 1955.000, SD 5.85 at aa 51-72, sequence SSTREIARQLGITQPLLYRYFP 216596028758 Putative cyclase; Region: Cyclase; pfam04199 216596028759 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 216596028760 classical (c) SDRs; Region: SDR_c; cd05233 216596028761 NAD(P) binding site [chemical binding]; other site 216596028762 active site 216596028763 Pfam match to entry PF00106.11 adh_short 216596028764 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 216596028765 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 216596028766 XdhC Rossmann domain; Region: XdhC_C; pfam13478 216596028767 Pfam match to entry PF02625.5 XdhC_CoxI 216596028768 similarity:fasta; SWALL:Q8KL49 (EMBL:U80928); Rhizobium etli; hypothetical protein; yp041; length 323 aa; 277 aa overlap; query 4-272 aa; subject 3-274 aa; conserved hypothetical protein, pseudogene 216596028769 Similar to codons 145 to 210 of Agrobacterium tumefaciens transcriptional regulator, lysr family SWALL:Q8UG33 (EMBL:AE009084) (322 aa); similarity:fasta; SWALL:Q8UG33 (EMBL:AE009084); Agrobacterium tumefaciens; transcriptional regulator, lysr family; length 322 aa; 60 aa overlap; query 8-67 aa; subject 146-205 aa; putative transcriptional regulator, pseudogene 216596028770 Transcriptional regulators [Transcription]; Region: PurR; COG1609 216596028771 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216596028772 DNA binding site [nucleotide binding] 216596028773 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 216596028774 putative dimerization interface [polypeptide binding]; other site 216596028775 putative ligand binding site [chemical binding]; other site 216596028776 Pfam match to entry PF00532.8 Peripla_BP_1 216596028777 Predicted helix-turn-helix motif with score 1472.000, SD 4.20 at aa 3-24, sequence PTAKQVAHVAGVSIAAVSRAFT 216596028778 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 216596028779 histidinol dehydrogenase; Region: hisD; TIGR00069 216596028780 NAD binding site [chemical binding]; other site 216596028781 dimerization interface [polypeptide binding]; other site 216596028782 product binding site; other site 216596028783 substrate binding site [chemical binding]; other site 216596028784 zinc binding site [ion binding]; other site 216596028785 catalytic residues [active] 216596028786 Pfam match to entry PF00815.8 Histidinol_dh 216596028787 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 216596028788 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 216596028789 ligand binding site [chemical binding]; other site 216596028790 homodimer interface [polypeptide binding]; other site 216596028791 NAD(P) binding site [chemical binding]; other site 216596028792 trimer interface B [polypeptide binding]; other site 216596028793 trimer interface A [polypeptide binding]; other site 216596028794 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 216596028795 Pfam match to entry PF05222.3 AlaDh_PNT_N 216596028796 Pfam match to entry PF01262.9 AlaDh_PNT_C 216596028797 5 probable transmembrane helices predicted at aa 170-192, 416-433, 437-459,466-488 and 492-514 216596028798 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 216596028799 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 216596028800 Pfam match to entry PF02233.5 PNTB 216596028801 9 probable transmembrane helices predicted at aa 4-26, 33-52, 57-74, 86-103,145-164, 177-199, 203-225, 232-251 and 256-275 216596028802 acetyl-CoA synthetase; Provisional; Region: PRK00174 216596028803 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 216596028804 active site 216596028805 CoA binding site [chemical binding]; other site 216596028806 acyl-activating enzyme (AAE) consensus motif; other site 216596028807 AMP binding site [chemical binding]; other site 216596028808 acetate binding site [chemical binding]; other site 216596028809 Pfam match to entry PF00501.11 AMP-binding 216596028810 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 216596028811 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 216596028812 Pfam match to entry PF01557.8 FAA_hydrolase 216596028813 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216596028814 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216596028815 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 216596028816 Pfam match to entry PF00440.8 TetR_N 216596028817 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216596028818 11 probable transmembrane helices predicted at aa 15-37, 50-72, 82-99, 104-126,136-158, 171-190, 220-242, 247-269, 289-311, 344-366 and 370-392 216596028819 Pfam match to entry PF07690.1 MFS_1 216596028820 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 216596028821 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216596028822 NAD(P) binding site [chemical binding]; other site 216596028823 active site 216596028824 Pfam match to entry PF00106.11 adh_short 216596028825 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 216596028826 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 216596028827 active site 216596028828 catalytic tetrad [active] 216596028829 Pfam match to entry PF00248.9 Aldo_ket_red 216596028830 Predicted helix-turn-helix motif with score 1014.000, SD 2.64 at aa 218-239, sequence TSWAQLALKFVLGHRAITCAIP 216596028831 similarity:fasta; SWALL:O52270 (EMBL:AF034088); Pseudomonas sp. B11-1; lipase; lipP; length 308 aa; 251 aa overlap; query 28-277 aa; subject 3-250 aa; similarity:fasta; SWALL:Q8XQW0 (EMBL:AL646082); Ralstonia solanacearum; probable lipase signal peptide protein; rsp1108 or rs02616; length 339 aa; 280 aa overlap; query 1-278 aa; subject 1-280 aa; putative exported lipase, pseudogene 216596028832 UNKNOWN FEATURE KEY ???; Signal peptide predicted for pRL80050 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.990 between residues 22 and 23 216596028833 similarity:fasta; SWALL:Q8Y173 (EMBL:AL646061); Ralstonia solanacearum; probable glutathione s-transferase protein; gst1 or rsc0817 or rs05005; length 206 aa; 189 aa overlap; query 6-181 aa; subject 15-200 aa; putative glutathione-S-transferase, pseudogene 216596028834 Pfam match to entry PF02798.6 GST_N 216596028835 1 probable transmembrane helix predicted at aa 118-140 216596028836 Lipocalin-like domain; Region: Lipocalin_5; pfam13924 216596028837 similarity:fasta; SWALL:Q52597 (EMBL:M10204); Agrobacterium tumefaciens; hypothetical protein; length 135 aa; 80 aa overlap; query 1-80 aa; subject 1-80 aa; similarity:fasta; SWALL:Q8YC22 (EMBL:AE009706); Brucella melitensis; transposase; bmeii0711; length 153 aa; 77 aa overlap; query 6-81 aa; subject 37-111 aa; putative transposase, pseudogene 216596028838 Pfam match to entry PF01527.7 Transposase_8 216596028839 Predicted helix-turn-helix motif with score 1503.000, SD 4.31 at aa 35-56, sequence AVISEIARAAGIHVSQLFRWRK 216596028840 Integrase core domain; Region: rve; pfam00665 216596028841 Integrase core domain; Region: rve_3; pfam13683 216596028842 Pfam match to entry PF00665.10 rve 216596028843 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 216596028844 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216596028845 non-specific DNA binding site [nucleotide binding]; other site 216596028846 salt bridge; other site 216596028847 sequence-specific DNA binding site [nucleotide binding]; other site 216596028848 Pfam match to entry PF01527.7 HTH_3 216596028849 DNA Polymerase Y-family; Region: PolY_like; cd03468 216596028850 active site 216596028851 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 216596028852 DNA binding site [nucleotide binding] 216596028853 N-terminal 242 residues are similar to Pseudomonas aeruginosa DNA polymerase III alpha subunit DnaE or pa3640 SWALL:DP3A_PSEAE (SWALL:Q9HXZ1) (1173 aa), and N-terminal 242 residues are similar to Agrobacterium tumefaciens DNA polymerase III, alpha chain DnaE or atu6093 or agr_pti_175 SWALL:Q8U642 (EMBL:AE009428) (1087 aa); similarity:fasta; SWALL:DP3A_PSEAE (SWALL:Q9HXZ1); Pseudomonas aeruginosa; DNA polymerase iii alpha subunit; dnae or pa3640; length 1173 aa; 258 aa overlap; query 1-241 aa; subject 3-260 aa; similarity:fasta; SWALL:Q8U642 (EMBL:AE009428); Agrobacterium tumefaciens; DNA polymerase iii, alpha chain; dnae or atu6093 or agr_pti_175; length 1087 aa; 241 aa overlap; query 1-241 aa; subject 1-241 aa; putative DNA polymerase III alpha subunit,pseudodene 216596028854 Pfam match to entry PF02231.5 PHP_N 216596028855 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 216596028856 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 216596028857 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216596028858 catalytic residue [active] 216596028859 Pfam match to entry PF00266.8 Aminotran_5 216596028860 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 216596028861 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 216596028862 substrate binding pocket [chemical binding]; other site 216596028863 membrane-bound complex binding site; other site 216596028864 hinge residues; other site 216596028865 Pfam match to entry PF00497.8 SBP_bac_3 216596028866 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596028867 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596028868 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 216596028869 substrate binding pocket [chemical binding]; other site 216596028870 dimerization interface [polypeptide binding]; other site 216596028871 Pfam match to entry PF00126.10 HTH_1 216596028872 Predicted helix-turn-helix motif with score 1400.000, SD 3.96 at aa 24-45, sequence RSVTRAADRLGRTQSAISHSLG 216596028873 Pfam match to entry PF03466.5 LysR_substrate 216596028874 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 216596028875 homotrimer interaction site [polypeptide binding]; other site 216596028876 putative active site [active] 216596028877 Pfam match to entry PF01042.8 Ribonuc_L-PSP 216596028878 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 216596028879 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 216596028880 Walker A/P-loop; other site 216596028881 ATP binding site [chemical binding]; other site 216596028882 Q-loop/lid; other site 216596028883 ABC transporter signature motif; other site 216596028884 Walker B; other site 216596028885 D-loop; other site 216596028886 H-loop/switch region; other site 216596028887 Pfam match to entry PF00005.11 ABC_tran 216596028888 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 216596028889 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596028890 dimer interface [polypeptide binding]; other site 216596028891 conserved gate region; other site 216596028892 putative PBP binding loops; other site 216596028893 ABC-ATPase subunit interface; other site 216596028894 Pfam match to entry PF00528.10 BPD_transp_1 216596028895 3 probable transmembrane helices predicted at aa 75-97, 107-129 and 258-280 216596028896 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 216596028897 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 216596028898 putative DNA binding site [nucleotide binding]; other site 216596028899 putative Zn2+ binding site [ion binding]; other site 216596028900 AsnC family; Region: AsnC_trans_reg; pfam01037 216596028901 Pfam match to entry PF01037.8 AsnC_trans_reg 216596028902 Predicted helix-turn-helix motif with score 1122.000, SD 3.01 at aa 22-43, sequence ASHAELSGKVNLSRNAVRVRIE 216596028903 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 216596028904 active site 216596028905 substrate binding site [chemical binding]; other site 216596028906 Phosphotransferase enzyme family; Region: APH; pfam01636 216596028907 ATP binding site [chemical binding]; other site 216596028908 Pfam match to entry PF01636.8 APH 216596028909 Class I aldolases; Region: Aldolase_Class_I; cl17187 216596028910 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 216596028911 tetramer interface [polypeptide binding]; other site 216596028912 Pfam match to entry PF00701.10 DHDPS 216596028913 Pfam match to entry PF00206.9 Lyase_1 216596028914 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 216596028915 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 216596028916 NAD(P) binding site [chemical binding]; other site 216596028917 catalytic residues [active] 216596028918 Pfam match to entry PF00171.9 Aldedh 216596028919 homoserine dehydrogenase; Provisional; Region: PRK06270 216596028920 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 216596028921 NAD(P) binding pocket [chemical binding]; other site 216596028922 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 216596028923 Pfam match to entry PF00742.8 Homoserine_dh 216596028924 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 216596028925 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 216596028926 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 216596028927 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216596028928 catalytic residue [active] 216596028929 Pfam match to entry PF00266.8 Aminotran_5 216596028930 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596028931 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596028932 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216596028933 dimerization interface [polypeptide binding]; other site 216596028934 Pfam match to entry PF03466.5 LysR_substrate 216596028935 Pfam match to entry PF00126.10 HTH_1 216596028936 Predicted helix-turn-helix motif with score 1616.000, SD 4.69 at aa 23-44, sequence KSVTGAARELKVSHSTVSRRLA 216596028937 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 216596028938 homotrimer interaction site [polypeptide binding]; other site 216596028939 putative active site [active] 216596028940 Pfam match to entry PF01042.8 Ribonuc_L-PSP 216596028941 Predicted amidohydrolase [General function prediction only]; Region: COG0388 216596028942 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 216596028943 putative active site [active] 216596028944 catalytic triad [active] 216596028945 putative dimer interface [polypeptide binding]; other site 216596028946 Pfam match to entry PF00795.10 CN_hydrolase 216596028947 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 216596028948 Moco binding site; other site 216596028949 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 216596028950 metal coordination site [ion binding]; other site 216596028951 Pfam match to entry PF00174.8 Oxidored_molyb 216596028952 Pfam match to entry PF03404.4 Mo-co_dimer 216596028953 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 216596028954 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 216596028955 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 216596028956 Pfam match to entry PF04198.2 Sugar-bind 216596028957 Predicted helix-turn-helix motif with score 1972.000, SD 5.90 at aa 123-144, sequence LTQNEVAAKLGVSRSTIVKLLD 216596028958 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 216596028959 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 216596028960 putative substrate binding site [chemical binding]; other site 216596028961 putative ATP binding site [chemical binding]; other site 216596028962 Pfam match to entry PF00294.10 PfkB 216596028963 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 216596028964 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 216596028965 nucleophilic elbow; other site 216596028966 catalytic triad; other site 216596028967 Pfam match to entry PF00561.8 Abhydrolase_1 216596028968 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 216596028969 E3 interaction surface; other site 216596028970 lipoyl attachment site [posttranslational modification]; other site 216596028971 Pfam match to entry PF00364.9 Biotin_lipoyl 216596028972 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 216596028973 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 216596028974 tetramer interface [polypeptide binding]; other site 216596028975 TPP-binding site [chemical binding]; other site 216596028976 heterodimer interface [polypeptide binding]; other site 216596028977 phosphorylation loop region [posttranslational modification] 216596028978 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 216596028979 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 216596028980 alpha subunit interface [polypeptide binding]; other site 216596028981 TPP binding site [chemical binding]; other site 216596028982 heterodimer interface [polypeptide binding]; other site 216596028983 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 216596028984 Pfam match to entry PF02780.6 Transketolase_C 216596028985 Pfam match to entry PF02779.8 Transket_pyr 216596028986 Pfam match to entry PF00676.8 E1_dh 216596028987 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 216596028988 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 216596028989 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 216596028990 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 216596028991 ligand binding site [chemical binding]; other site 216596028992 Pfam match to entry PF00532.8 Peripla_BP_1 216596028993 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 216596028994 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 216596028995 Walker A/P-loop; other site 216596028996 ATP binding site [chemical binding]; other site 216596028997 Q-loop/lid; other site 216596028998 ABC transporter signature motif; other site 216596028999 Walker B; other site 216596029000 D-loop; other site 216596029001 H-loop/switch region; other site 216596029002 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 216596029003 Pfam match to entry PF00005.11 ABC_tran 216596029004 Pfam match to entry PF00005.11 ABC_tran 216596029005 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216596029006 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596029007 TM-ABC transporter signature motif; other site 216596029008 8 probable transmembrane helices predicted at aa 15-37, 49-71, 91-113, 120-142,168-190, 211-233, 274-296 and 303-320 216596029009 Pfam match to entry PF02653.5 BPD_transp_2 216596029010 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216596029011 TM-ABC transporter signature motif; other site 216596029012 10 probable transmembrane helices predicted at aa 27-49, 59-81, 86-108, 118-140,147-169, 189-211, 241-263, 268-287, 296-318 and 322-344 216596029013 Pfam match to entry PF02653.5 BPD_transp_2 216596029014 Similar to N-terminal 70 residues of Agrobacterium tumefaciens transaldolase Tal or TalB or atu4464 or agr_l_812 SWALL:TAL_AGRT5 (SWALL:Q8U7I5) (321 aa); similarity:fasta; SWALL:TAL_AGRT5 (SWALL:Q8U7I5); Agrobacterium tumefaciens; transaldolase; tal or talb or atu4464 or agr_l_812; length 321 aa; 62 aa overlap; query 3-64 aa; subject 4-65 aa; putative transaldolase, pseudogene 216596029015 Pfam match to entry PF00923.8 Transaldolase 216596029016 Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154 216596029017 Pfam match to entry PF05025.2 RbsD_FucU 216596029018 Similar to C-terminal 51 residues of Rhizobium loti ribokinase mlr8492 SWALL:Q982U3 (EMBL:AP003014) (309 aa); similarity:fasta; SWALL:Q982U3 (EMBL:AP003014); Rhizobium loti; ribokinase; mlr8492; length 309 aa; 52 aa overlap; query 11-62 aa; subject 258-309 aa; putative ribokinase, pseudogene 216596029019 Pfam match to entry PF00294.10 PfkB 216596029020 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 216596029021 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 216596029022 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596029023 dimer interface [polypeptide binding]; other site 216596029024 ABC-ATPase subunit interface; other site 216596029025 putative PBP binding loops; other site 216596029026 6 probable transmembrane helices predicted at aa 9-31, 70-92, 104-126, 199-221,228-250 and 260-282 216596029027 Pfam match to entry PF00528.10 BPD_transp_1 216596029028 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216596029029 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596029030 dimer interface [polypeptide binding]; other site 216596029031 conserved gate region; other site 216596029032 putative PBP binding loops; other site 216596029033 ABC-ATPase subunit interface; other site 216596029034 9 probable transmembrane helices predicted at aa 12-34, 44-66, 73-95, 105-127,132-154, 169-191, 203-225, 262-284 and 307-329 216596029035 Pfam match to entry PF00528.10 BPD_transp_1 216596029036 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 216596029037 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 216596029038 Pfam match to entry PF01547.11 SBP_bac_1 216596029039 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 216596029040 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 216596029041 Walker A/P-loop; other site 216596029042 ATP binding site [chemical binding]; other site 216596029043 Q-loop/lid; other site 216596029044 ABC transporter signature motif; other site 216596029045 Walker B; other site 216596029046 D-loop; other site 216596029047 H-loop/switch region; other site 216596029048 TOBE domain; Region: TOBE_2; pfam08402 216596029049 Pfam match to entry PF00005.11 ABC_tran 216596029050 Pfam match to entry PF03459.4 TOBE 216596029051 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 216596029052 Helix-turn-helix domain; Region: HTH_38; pfam13936 216596029053 DNA-binding interface [nucleotide binding]; DNA binding site 216596029054 Integrase core domain; Region: rve; pfam00665 216596029055 Predicted helix-turn-helix motif with score 1422.000, SD 4.03 at aa 24-45, sequence VPVNEMARQLGRHRSTIYREIK 216596029056 Pfam match to entry PF00665.10 rve 216596029057 Protein of unknown function, DUF488; Region: DUF488; pfam04343 216596029058 Pfam match to entry PF06571.1 DUF1130 216596029059 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 216596029060 GIY-YIG motif/motif A; other site 216596029061 active site 216596029062 catalytic site [active] 216596029063 Catalytic GIY-YIG domain of coliphage T4 non-specific endonuclease II, type II restriction endonuclease R.Hpy188I, and similar proteins; Region: GIY-YIG_EndoII_Hpy188I_like; cd10436 216596029064 GIY-YIG motif/motif A; other site 216596029065 DNA binding site [nucleotide binding] 216596029066 active site 216596029067 catalytic site [active] 216596029068 metal binding site [ion binding]; metal-binding site 216596029069 Predicted helix-turn-helix motif with score 1153.000, SD 3.11 at aa 292-313, sequence LKAADIAARLGIRYQHAYNVIN 216596029070 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 216596029071 Toprim-like; Region: Toprim_2; pfam13155 216596029072 Protein of unknown function (DUF1419); Region: DUF1419; pfam07215 216596029073 Pfam match to entry PF07215.1 DUF1419 216596029074 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 216596029075 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596029076 S-adenosylmethionine binding site [chemical binding]; other site 216596029077 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 216596029078 DEAD-like helicases superfamily; Region: DEXDc; smart00487 216596029079 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 216596029080 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 216596029081 helicase superfamily c-terminal domain; Region: HELICc; smart00490 216596029082 Pfam match to entry PF00271.14 Helicase_C 216596029083 Putative pseudogene, frameshift after codon 56,similar to Agrobacterium tumefaciens chromosome partitioning protein ParB or atu6103 or agr_pti_191 SWALL:Q8U632 (EMBL:AE009429) (653 aa); similarity:fasta; SWALL:Q8U632 (EMBL:AE009429); Agrobacterium tumefaciens; chromosome partitioning protein; parb or atu6103 or agr_pti_191; length 653 aa; 643 aa overlap; query 5-638 aa; subject 17-653 aa; puative ParB-like partitioning protein,pseudogene 216596029084 Pfam match to entry PF02195.5 ParBc 216596029085 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 216596029086 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 216596029087 Uncharacterized conserved protein [Function unknown]; Region: COG5489 216596029088 Pfam match to entry PF05284.1 DUF736 216596029089 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 216596029090 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 216596029091 Catalytic site; other site 216596029092 Pfam match to entry PF00565.7 SNase 216596029093 1 probable transmembrane helix predicted at aa 5-27 216596029094 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 216596029095 Pfam match to entry PF05406.2 WGR 216596029096 conjugal transfer coupling protein TraG; Provisional; Region: PRK13822 216596029097 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 216596029098 Walker A motif; other site 216596029099 ATP binding site [chemical binding]; other site 216596029100 Walker B motif; other site 216596029101 Pfam match to entry PF02534.4 TraG 216596029102 Predicted helix-turn-helix motif with score 980.000, SD 2.52 at aa 495-516, sequence ETARDAGRKYGITLTMIYQSIG 216596029103 2 probable transmembrane helices predicted at aa 41-63 and 75-92 216596029104 conjugal transfer protein TraD; Provisional; Region: PRK13847 216596029105 TraC-like protein; Region: TraC; cl06725 216596029106 Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768 216596029107 MobA/MobL family; Region: MobA_MobL; pfam03389 216596029108 AAA domain; Region: AAA_30; pfam13604 216596029109 Family description; Region: UvrD_C_2; pfam13538 216596029110 Pfam match to entry PF03389.3 MobA_MobL 216596029111 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 216596029112 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 216596029113 conjugal transfer protein TraB; Provisional; Region: PRK13825 216596029114 active site 216596029115 catalytic triad [active] 216596029116 Pfam match to entry PF07186.1 TraB_2 216596029117 6 probable transmembrane helices predicted at aa 31-53, 60-82, 87-109, 118-140,144-166 and 173-192 216596029118 conjugal transfer protein TraH; Provisional; Region: PRK13843 216596029119 Pfam match to entry PF06871.1 TraH_2 216596029120 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 216596029121 7 probable transmembrane helices predicted at aa 160-182, 205-227, 259-281,313-335, 371-393, 432-454 and 475-497 216596029122 Autoinducer binding domain; Region: Autoind_bind; pfam03472 216596029123 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216596029124 DNA binding residues [nucleotide binding] 216596029125 dimerization interface [polypeptide binding]; other site 216596029126 Pfam match to entry PF03472.4 Autoind_bind 216596029127 Prokaryotic Transcriptional repressor TraM; Region: Prok-TraM; pfam09228 216596029128 conjugal transfer protein TrbI; Provisional; Region: PRK13831 216596029129 Pfam match to entry PF03743.3 TrbI 216596029130 1 probable transmembrane helix predicted at aa 25-47 216596029131 conjugal transfer protein TrbH; Provisional; Region: PRK13835 216596029132 Conjugal transfer protein TrbH; Region: TrbH; pfam07283 216596029133 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 216596029134 VirB7 interaction site; other site 216596029135 Pfam match to entry PF03524.4 CagX 216596029136 conjugal transfer protein TrbF; Provisional; Region: PRK13836 216596029137 Pfam match to entry PF04585.2 TrbF 216596029138 1 probable transmembrane helix predicted at aa 31-53 216596029139 conjugal transfer protein TrbL; Provisional; Region: PRK13841 216596029140 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 216596029141 7 probable transmembrane helices predicted at aa 58-80, 90-112, 154-176,180-199, 206-228, 248-270 and 295-317 216596029142 Pfam match to entry PF04610.3 TrbL 216596029143 conjugal transfer protein TrbJ; Provisional; Region: PRK13842 216596029144 Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314 216596029145 conjugal transfer protein TrbE; Provisional; Region: PRK13830 216596029146 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 216596029147 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216596029148 Walker A/P-loop; other site 216596029149 ATP binding site [chemical binding]; other site 216596029150 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216596029151 Walker B; other site 216596029152 D-loop; other site 216596029153 H-loop/switch region; other site 216596029154 Pfam match to entry PF03135.4 CagE_TrbE_VirB 216596029155 conjugal transfer protein TrbD; Provisional; Region: PRK13823 216596029156 Pfam match to entry PF05245.1 TrbD 216596029157 1 probable transmembrane helix predicted at aa 31-65 216596029158 conjugal transfer protein TrbC; Provisional; Region: PRK13871 216596029159 2 probable transmembrane helices predicted at aa 50-72 and 84-106 216596029160 Pfam match to entry PF04956.2 TrbC 216596029161 conjugal transfer protein TrbB; Provisional; Region: PRK13833 216596029162 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 216596029163 ATP binding site [chemical binding]; other site 216596029164 Walker A motif; other site 216596029165 hexamer interface [polypeptide binding]; other site 216596029166 Walker B motif; other site 216596029167 Pfam match to entry PF00437.9 GSPII_E 216596029168 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 216596029169 MerR family regulatory protein; Region: MerR; pfam00376 216596029170 DNA binding residues [nucleotide binding] 216596029171 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 216596029172 P-loop; other site 216596029173 Magnesium ion binding site [ion binding]; other site 216596029174 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 216596029175 Magnesium ion binding site [ion binding]; other site 216596029176 Pfam match to entry PF00376.9 MerR 216596029177 Pfam match to entry PF01656.8 CbiA 216596029178 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 216596029179 ParB-like nuclease domain; Region: ParBc; pfam02195 216596029180 Pfam match to entry PF02195.5 ParBc 216596029181 Pfam match to entry PF07506.1 RepB 216596029182 replication initiation protein RepC; Provisional; Region: PRK13824 216596029183 Replication protein C N-terminal domain; Region: RP-C; pfam03428 216596029184 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 216596029185 Pfam match to entry PF03428.3 RP-C 216596029186 Protein of unknown function (DUF1612); Region: DUF1612; pfam07756 216596029187 HTH DNA binding domain; Region: HTH_13; pfam11972 216596029188 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 216596029189 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 216596029190 Pfam match to entry PF01027.9 UPF0005 216596029191 7 probable transmembrane helices predicted at aa 31-53, 57-79, 92-114, 119-136,143-165, 169-188 and 209-231 216596029192 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 216596029193 RNA polymerase sigma factor; Provisional; Region: PRK12511 216596029194 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216596029195 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 216596029196 DNA binding residues [nucleotide binding] 216596029197 Pfam match to entry PF04545.3 Sigma70_r4 216596029198 Predicted helix-turn-helix motif with score 1431.000, SD 4.06 at aa 128-149, sequence LSYQEAAQALGIPVGTLMSRIS 216596029199 Pfam match to entry PF04542.2 Sigma70_r2 216596029200 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 216596029201 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 216596029202 DNA binding residues [nucleotide binding] 216596029203 dimer interface [polypeptide binding]; other site 216596029204 copper binding site [ion binding]; other site 216596029205 Pfam match to entry PF00376.9 MerR 216596029206 Predicted helix-turn-helix motif with score 1156.000, SD 3.12 at aa 1-22, sequence MNIGEASERSGLPSKTIRYYED 216596029207 YHS domain; Region: YHS; pfam04945 216596029208 YHS domain; Region: YHS; pfam04945 216596029209 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 216596029210 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 216596029211 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216596029212 motif II; other site 216596029213 8 probable transmembrane helices predicted at aa 154-176, 186-206, 219-241,251-273, 411-433, 443-462, 754-776 and 780-802 216596029214 Pfam match to entry PF00702.10 Hydrolase 216596029215 Pfam match to entry PF00122.7 E1-E2_ATPase 216596029216 Pfam match to entry PF04945.2 YHS 216596029217 Pfam match to entry PF04945.2 YHS 216596029218 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 216596029219 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 216596029220 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 216596029221 active site 216596029222 catalytic site [active] 216596029223 Pfam match to entry PF00128.11 Alpha-amylase 216596029224 Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953 216596029225 Transglycosylase; Region: Transgly; pfam00912 216596029226 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 216596029227 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 216596029228 Pfam match to entry PF06832.1 BiPBP_C 216596029229 Pfam match to entry PF00905.9 Transpeptidase 216596029230 Pfam match to entry PF00912.9 Transgly 216596029231 1 probable transmembrane helix predicted at aa 7-25 216596029232 Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or...; Region: APPLE_Factor_XI_like; cd01100 216596029233 putative binding site; other site 216596029234 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 216596029235 MG2 domain; Region: A2M_N; pfam01835 216596029236 Alpha-2-macroglobulin family; Region: A2M; pfam00207 216596029237 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 216596029238 surface patch; other site 216596029239 thioester region; other site 216596029240 specificity defining residues; other site 216596029241 Pfam match to entry PF07703.1 A2M_N_2 216596029242 Pfam match to entry PF01835.8 A2M_N 216596029243 Pfam match to entry PF05738.2 Cna_B 216596029244 Pfam match to entry PF00024.12 PAN 216596029245 1 probable transmembrane helix predicted at aa 7-26 216596029246 methionine sulfoxide reductase A; Provisional; Region: PRK13014 216596029247 Pfam match to entry PF01625.8 PMSR 216596029248 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 216596029249 Pfam match to entry PF03734.4 ErfK_YbiS_YhnG 216596029250 response regulator; Provisional; Region: PRK13435 216596029251 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216596029252 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216596029253 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 216596029254 Pfam match to entry PF00440.8 TetR_N 216596029255 Predicted helix-turn-helix motif with score 1594.000, SD 4.62 at aa 54-75, sequence ASIDEIAAVACVSRQTIYNHYR 216596029256 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 216596029257 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596029258 putative substrate translocation pore; other site 216596029259 12 probable transmembrane helices predicted at aa 7-29, 44-66, 73-93, 98-120,132-154, 158-180, 211-233, 248-270, 282-301, 306-328,341-363 and 368-390 216596029260 Pfam match to entry PF00083.10 Sugar_tr 216596029261 Pfam match to entry PF07690.1 MFS_1 216596029262 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 216596029263 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596029264 putative substrate translocation pore; other site 216596029265 12 probable transmembrane helices predicted at aa 7-28, 43-65, 78-100, 105-127,140-162, 175-197, 240-262, 272-294, 306-325, 329-351,358-380 and 395-414 216596029266 Pfam match to entry PF00083.10 Sugar_tr 216596029267 Pfam match to entry PF07690.1 MFS_1 216596029268 NMT1/THI5 like; Region: NMT1; pfam09084 216596029269 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 216596029270 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 216596029271 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 216596029272 Walker A/P-loop; other site 216596029273 ATP binding site [chemical binding]; other site 216596029274 Q-loop/lid; other site 216596029275 ABC transporter signature motif; other site 216596029276 Walker B; other site 216596029277 D-loop; other site 216596029278 H-loop/switch region; other site 216596029279 Pfam match to entry PF00005.11 ABC_tran 216596029280 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 216596029281 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 216596029282 6 probable transmembrane helices predicted at aa 31-53, 84-106, 113-135,145-167, 208-230 and 240-262 216596029283 Pfam match to entry PF00528.10 BPD_transp_1 216596029284 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 216596029285 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 216596029286 CoA-transferase family III; Region: CoA_transf_3; pfam02515 216596029287 Pfam match to entry PF02515.5 CoA_transf_3 216596029288 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 216596029289 enoyl-CoA hydratase; Provisional; Region: PRK06494 216596029290 substrate binding site [chemical binding]; other site 216596029291 oxyanion hole (OAH) forming residues; other site 216596029292 trimer interface [polypeptide binding]; other site 216596029293 Pfam match to entry PF00378.8 ECH 216596029294 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596029295 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596029296 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216596029297 dimerization interface [polypeptide binding]; other site 216596029298 Pfam match to entry PF00126.10 HTH_1 216596029299 Predicted helix-turn-helix motif with score 1782.000, SD 5.26 at aa 16-37, sequence GSIRKASDELHVATSAVSRQIK 216596029300 Pfam match to entry PF03466.5 LysR_substrate 216596029301 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 216596029302 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 216596029303 active site 216596029304 Pfam match to entry PF01979.7 Amidohydro_1 216596029305 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 216596029306 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 216596029307 inhibitor site; inhibition site 216596029308 active site 216596029309 dimer interface [polypeptide binding]; other site 216596029310 catalytic residue [active] 216596029311 Pfam match to entry PF00701.10 DHDPS 216596029312 Ferredoxin [Energy production and conversion]; Region: COG1146 216596029313 4Fe-4S binding domain; Region: Fer4; pfam00037 216596029314 Pfam match to entry PF00037.11 Fer4 216596029315 Transcriptional regulators [Transcription]; Region: PurR; COG1609 216596029316 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216596029317 DNA binding site [nucleotide binding] 216596029318 domain linker motif; other site 216596029319 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 216596029320 ligand binding site [chemical binding]; other site 216596029321 Pfam match to entry PF00532.8 Peripla_BP_1 216596029322 Predicted helix-turn-helix motif with score 1934.000, SD 5.77 at aa 24-45, sequence KGIRQLAEHLDISIGTVSRALN 216596029323 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216596029324 Transcriptional regulators [Transcription]; Region: PurR; COG1609 216596029325 DNA binding site [nucleotide binding] 216596029326 domain linker motif; other site 216596029327 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 216596029328 putative dimerization interface [polypeptide binding]; other site 216596029329 putative ligand binding site [chemical binding]; other site 216596029330 Pfam match to entry PF00532.8 Peripla_BP_1 216596029331 Predicted helix-turn-helix motif with score 1941.000, SD 5.80 at aa 20-41, sequence VSAEQVAQLAGVSRSAVSRTFT 216596029332 2 probable transmembrane helices predicted at aa 5-24 and 34-56 216596029333 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 216596029334 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 216596029335 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 216596029336 Walker A/P-loop; other site 216596029337 ATP binding site [chemical binding]; other site 216596029338 Q-loop/lid; other site 216596029339 ABC transporter signature motif; other site 216596029340 Walker B; other site 216596029341 D-loop; other site 216596029342 H-loop/switch region; other site 216596029343 Pfam match to entry PF00005.11 ABC_tran 216596029344 Pfam match to entry PF00664.10 ABC_membrane 216596029345 5 probable transmembrane helices predicted at aa 87-109, 124-143, 204-223,227-246 and 310-332 216596029346 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 216596029347 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 216596029348 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216596029349 Walker A/P-loop; other site 216596029350 ATP binding site [chemical binding]; other site 216596029351 Q-loop/lid; other site 216596029352 ABC transporter signature motif; other site 216596029353 Walker B; other site 216596029354 D-loop; other site 216596029355 H-loop/switch region; other site 216596029356 Pfam match to entry PF00005.11 ABC_tran 216596029357 5 probable transmembrane helices predicted at aa 79-101, 121-143, 208-230,309-331 and 338-360 216596029358 Pfam match to entry PF00664.10 ABC_membrane 216596029359 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 216596029360 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 216596029361 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 216596029362 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 216596029363 PAS domain S-box; Region: sensory_box; TIGR00229 216596029364 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216596029365 putative active site [active] 216596029366 heme pocket [chemical binding]; other site 216596029367 PAS domain S-box; Region: sensory_box; TIGR00229 216596029368 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216596029369 putative active site [active] 216596029370 heme pocket [chemical binding]; other site 216596029371 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 216596029372 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216596029373 dimer interface [polypeptide binding]; other site 216596029374 phosphorylation site [posttranslational modification] 216596029375 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596029376 ATP binding site [chemical binding]; other site 216596029377 Mg2+ binding site [ion binding]; other site 216596029378 G-X-G motif; other site 216596029379 Response regulator receiver domain; Region: Response_reg; pfam00072 216596029380 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596029381 active site 216596029382 phosphorylation site [posttranslational modification] 216596029383 intermolecular recognition site; other site 216596029384 dimerization interface [polypeptide binding]; other site 216596029385 Pfam match to entry PF00989.11 PAS 216596029386 Pfam match to entry PF00785.11 PAC 216596029387 Pfam match to entry PF00989.11 PAS 216596029388 Pfam match to entry PF00785.11 PAC 216596029389 Pfam match to entry PF00512.10 HisKA 216596029390 Pfam match to entry PF02518.9 HATPase_c 216596029391 Pfam match to entry PF00072.10 Response_reg 216596029392 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 216596029393 Pfam match to entry PF02104.5 SURF1 216596029394 2 probable transmembrane helices predicted at aa 28-50 and 230-252 216596029395 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 216596029396 Pfam match to entry PF03626.3 COX4_pro 216596029397 3 probable transmembrane helices predicted at aa 32-54, 59-81 and 91-113 216596029398 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 216596029399 Subunit I/III interface [polypeptide binding]; other site 216596029400 Subunit III/IV interface [polypeptide binding]; other site 216596029401 Pfam match to entry PF00510.8 COX3 216596029402 5 probable transmembrane helices predicted at aa 33-55, 70-92, 105-127, 142-164 and 185-207 216596029403 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 216596029404 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 216596029405 D-pathway; other site 216596029406 Putative ubiquinol binding site [chemical binding]; other site 216596029407 Low-spin heme (heme b) binding site [chemical binding]; other site 216596029408 Putative water exit pathway; other site 216596029409 Binuclear center (heme o3/CuB) [ion binding]; other site 216596029410 K-pathway; other site 216596029411 Putative proton exit pathway; other site 216596029412 14 probable transmembrane helices predicted at aa 26-48, 67-89, 115-137,150-172, 201-223, 243-265, 285-307, 320-342, 357-379,392-414, 424-446, 467-489, 502-524 and 613-635 216596029413 Pfam match to entry PF00115.8 COX1 216596029414 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 216596029415 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 216596029416 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 216596029417 Pfam match to entry PF06481.2 COX_ARM 216596029418 3 probable transmembrane helices predicted at aa 7-29, 42-64 and 85-107 216596029419 metabolite-proton symporter; Region: 2A0106; TIGR00883 216596029420 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596029421 putative substrate translocation pore; other site 216596029422 Pfam match to entry PF00083.10 Sugar_tr 216596029423 12 probable transmembrane helices predicted at aa 44-63, 73-95, 107-126,131-153, 174-196, 206-225, 261-283, 293-315, 327-346,356-378, 385-407 and 417-439 216596029424 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 216596029425 Pfam match to entry PF05016.3 Plasmid_stabil 216596029426 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 216596029427 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 216596029428 ligand binding site [chemical binding]; other site 216596029429 flexible hinge region; other site 216596029430 Pfam match to entry PF00027.13 cNMP_binding 216596029431 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 216596029432 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 216596029433 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 216596029434 Walker A/P-loop; other site 216596029435 ATP binding site [chemical binding]; other site 216596029436 Q-loop/lid; other site 216596029437 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 216596029438 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 216596029439 ABC transporter signature motif; other site 216596029440 Walker B; other site 216596029441 D-loop; other site 216596029442 H-loop/switch region; other site 216596029443 Pfam match to entry PF00005.11 ABC_tran 216596029444 Pfam match to entry PF00664.10 ABC_membrane 216596029445 5 probable transmembrane helices predicted at aa 13-35, 86-108, 165-184,188-205 and 276-298 216596029446 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 216596029447 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 216596029448 colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005 216596029449 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 216596029450 putative ADP-binding pocket [chemical binding]; other site 216596029451 Pfam match to entry PF00534.8 Glycos_transf_1 216596029452 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 216596029453 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 216596029454 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 216596029455 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 216596029456 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596029457 dimer interface [polypeptide binding]; other site 216596029458 conserved gate region; other site 216596029459 putative PBP binding loops; other site 216596029460 ABC-ATPase subunit interface; other site 216596029461 Pfam match to entry PF00528.10 BPD_transp_1 216596029462 6 probable transmembrane helices predicted at aa 53-75, 144-166, 187-209,240-262, 302-324 and 356-378 216596029463 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 216596029464 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596029465 dimer interface [polypeptide binding]; other site 216596029466 conserved gate region; other site 216596029467 putative PBP binding loops; other site 216596029468 ABC-ATPase subunit interface; other site 216596029469 Pfam match to entry PF00528.10 BPD_transp_1 216596029470 6 probable transmembrane helices predicted at aa 5-27, 101-123, 136-158,191-213, 251-273 and 298-320 216596029471 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 216596029472 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 216596029473 Pfam match to entry PF00496.9 SBP_bac_5 216596029474 1 probable transmembrane helix predicted at aa 7-26 216596029475 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 216596029476 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596029477 Walker A/P-loop; other site 216596029478 ATP binding site [chemical binding]; other site 216596029479 Q-loop/lid; other site 216596029480 ABC transporter signature motif; other site 216596029481 Walker B; other site 216596029482 D-loop; other site 216596029483 H-loop/switch region; other site 216596029484 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 216596029485 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596029486 Walker A/P-loop; other site 216596029487 ATP binding site [chemical binding]; other site 216596029488 Q-loop/lid; other site 216596029489 ABC transporter signature motif; other site 216596029490 Walker B; other site 216596029491 D-loop; other site 216596029492 H-loop/switch region; other site 216596029493 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216596029494 Pfam match to entry PF00005.11 ABC_tran 216596029495 Pfam match to entry PF00005.11 ABC_tran 216596029496 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 216596029497 cyclase homology domain; Region: CHD; cd07302 216596029498 nucleotidyl binding site; other site 216596029499 metal binding site [ion binding]; metal-binding site 216596029500 dimer interface [polypeptide binding]; other site 216596029501 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 216596029502 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216596029503 NAD(P) binding site [chemical binding]; other site 216596029504 active site 216596029505 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 216596029506 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 216596029507 Pfam match to entry PF03721.3 UDPG_MGDP_dh_N 216596029508 1 probable transmembrane helix predicted at aa 20-42 216596029509 Pfam match to entry PF00984.8 UDPG_MGDP_dh 216596029510 Pfam match to entry PF03720.3 UDPG_MGDP_dh_C 216596029511 Protein of unknown function (DUF3095); Region: DUF3095; pfam11294 216596029512 1 probable transmembrane helix predicted at aa 277-299 216596029513 S-adenosyl-L-methionine methyltransferase; Region: Methyltransf_17; pfam12692 216596029514 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 216596029515 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 216596029516 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 216596029517 Walker A/P-loop; other site 216596029518 ATP binding site [chemical binding]; other site 216596029519 Q-loop/lid; other site 216596029520 ABC transporter signature motif; other site 216596029521 Walker B; other site 216596029522 D-loop; other site 216596029523 H-loop/switch region; other site 216596029524 Pfam match to entry PF00005.11 ABC_tran 216596029525 6 probable transmembrane helices predicted at aa 29-51, 71-90, 146-168,172-194, 257-279 and 289-306 216596029526 Pfam match to entry PF00664.10 ABC_membrane 216596029527 Predicted transcriptional regulator [Transcription]; Region: COG1959 216596029528 Transcriptional regulator; Region: Rrf2; pfam02082 216596029529 Pfam match to entry PF02082.5 Rrf2 216596029530 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 216596029531 Pfam match to entry PF00070.12 Pyr_redox 216596029532 RES domain; Region: RES; smart00953 216596029533 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 216596029534 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 216596029535 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 216596029536 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 216596029537 catalytic loop [active] 216596029538 iron binding site [ion binding]; other site 216596029539 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 216596029540 cyclase homology domain; Region: CHD; cd07302 216596029541 nucleotidyl binding site; other site 216596029542 metal binding site [ion binding]; metal-binding site 216596029543 dimer interface [polypeptide binding]; other site 216596029544 Pfam match to entry PF00211.9 Guanylate_cyc 216596029545 Pfam match to entry PF00111.12 Fer2 216596029546 6 probable transmembrane helices predicted at aa 20-42, 62-84, 96-118, 143-165,174-196 and 232-254 216596029547 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 216596029548 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 216596029549 Pfam match to entry PF00534.8 Glycos_transf_1 216596029550 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u4; cd10928 216596029551 NodB motif; other site 216596029552 putative active site [active] 216596029553 putative catalytic site [active] 216596029554 putative Zn binding site [ion binding]; other site 216596029555 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 216596029556 Pfam match to entry PF00561.8 Abhydrolase_1 216596029557 Uncharacterized conserved protein [Function unknown]; Region: COG3791 216596029558 Pfam match to entry PF04828.3 DUF636 216596029559 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 216596029560 Pfam match to entry PF00753.13 Lactamase_B 216596029561 Transcriptional regulators [Transcription]; Region: GntR; COG1802 216596029562 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596029563 DNA-binding site [nucleotide binding]; DNA binding site 216596029564 FCD domain; Region: FCD; pfam07729 216596029565 Pfam match to entry PF00392.9 GntR 216596029566 Transcriptional regulators [Transcription]; Region: GntR; COG1802 216596029567 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596029568 DNA-binding site [nucleotide binding]; DNA binding site 216596029569 FCD domain; Region: FCD; pfam07729 216596029570 Pfam match to entry PF00392.9 GntR 216596029571 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 216596029572 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 216596029573 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 216596029574 dimer interface [polypeptide binding]; other site 216596029575 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 216596029576 active site 216596029577 Fe binding site [ion binding]; other site 216596029578 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 216596029579 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 216596029580 substrate binding pocket [chemical binding]; other site 216596029581 membrane-bound complex binding site; other site 216596029582 hinge residues; other site 216596029583 1 probable transmembrane helix predicted at aa 13-32 216596029584 Pfam match to entry PF00497.8 SBP_bac_3 216596029585 Dehydroquinase class II; Region: DHquinase_II; pfam01220 216596029586 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 216596029587 trimer interface [polypeptide binding]; other site 216596029588 active site 216596029589 dimer interface [polypeptide binding]; other site 216596029590 Pfam match to entry PF01220.7 DHquinase_II 216596029591 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596029592 dimer interface [polypeptide binding]; other site 216596029593 conserved gate region; other site 216596029594 putative PBP binding loops; other site 216596029595 ABC-ATPase subunit interface; other site 216596029596 Pfam match to entry PF00528.10 BPD_transp_1 216596029597 5 probable transmembrane helices predicted at aa 23-45, 57-79, 94-113, 146-168 and 188-210 216596029598 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 216596029599 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596029600 dimer interface [polypeptide binding]; other site 216596029601 conserved gate region; other site 216596029602 putative PBP binding loops; other site 216596029603 ABC-ATPase subunit interface; other site 216596029604 Pfam match to entry PF00528.10 BPD_transp_1 216596029605 5 probable transmembrane helices predicted at aa 15-37, 50-72, 82-101, 138-160 and 180-202 216596029606 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 216596029607 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 216596029608 Walker A/P-loop; other site 216596029609 ATP binding site [chemical binding]; other site 216596029610 Q-loop/lid; other site 216596029611 ABC transporter signature motif; other site 216596029612 Walker B; other site 216596029613 D-loop; other site 216596029614 H-loop/switch region; other site 216596029615 Pfam match to entry PF00005.11 ABC_tran 216596029616 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 216596029617 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 216596029618 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 216596029619 Pfam match to entry PF01408.8 GFO_IDH_MocA 216596029620 Pfam match to entry PF02894.4 GFO_IDH_MocA_C 216596029621 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 216596029622 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 216596029623 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 216596029624 shikimate binding site; other site 216596029625 NAD(P) binding site [chemical binding]; other site 216596029626 Pfam match to entry PF01488.6 Shikimate_DH 216596029627 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216596029628 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216596029629 Pfam match to entry PF00440.8 TetR_N 216596029630 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216596029631 NAD(P) binding site [chemical binding]; other site 216596029632 gluconate 5-dehydrogenase; Provisional; Region: PRK07523 216596029633 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 216596029634 NADP binding site [chemical binding]; other site 216596029635 homodimer interface [polypeptide binding]; other site 216596029636 active site 216596029637 Pfam match to entry PF00106.11 adh_short 216596029638 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK05975 216596029639 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 216596029640 tetramer interface [polypeptide binding]; other site 216596029641 Pfam match to entry PF00206.9 Lyase_1 216596029642 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 216596029643 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 216596029644 heterodimer interface [polypeptide binding]; other site 216596029645 active site 216596029646 Pfam match to entry PF00775.10 Dioxygenase_C 216596029647 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 216596029648 heterodimer interface [polypeptide binding]; other site 216596029649 multimer interface [polypeptide binding]; other site 216596029650 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 216596029651 active site 216596029652 Pfam match to entry PF00775.10 Dioxygenase_C 216596029653 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 216596029654 Pfam match to entry PF02627.6 CMD 216596029655 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 216596029656 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 216596029657 Pfam match to entry PF00561.8 Abhydrolase_1 216596029658 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 216596029659 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596029660 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216596029661 dimerization interface [polypeptide binding]; other site 216596029662 Pfam match to entry PF00126.10 HTH_1 216596029663 Predicted helix-turn-helix motif with score 1366.000, SD 3.84 at aa 24-45, sequence KSVMKAAELLHVSQPAVTKTIR 216596029664 Pfam match to entry PF03466.5 LysR_substrate 216596029665 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 216596029666 RES domain; Region: RES; smart00953 216596029667 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 216596029668 N-terminus (no obvious start site) to codon 175 is similar to Bradyrhizobium sp. UPM1167 hydrogenase small subunit hupS SWALL:Q8L2Z2 (EMBL:AF466157) (179 aa); similarity:fasta; SWALL:Q8L2Z2 (EMBL:AF466157); Bradyrhizobium sp. UPM1167; hydrogenase small subunit; hupS; length 179 aa; 182 aa overlap; query 1-173 aa; subject 10-177 aa; putative hydrogenase subunit, pseudogene 216596029669 N-terminus to codon 55 is similar to N-terminus to codon 55 of Caulobacter crescentus methylated-DNA--protein-cysteine methyltransferase SWALL:Q9AAB5 (EMBL:AE005744) (220 aa); similarity:fasta; SWALL:Q9AAB5 (EMBL:AE005744); Caulobacter crescentus; methylated-DNA--protein-cysteine methyltransferase; length 220 aa; 59 aa overlap; query 1-58 aa; subject 1-57 aa; conserved hypothetical protein, pseudogene 216596029670 N-terminus is similar to N-terminus of Rhodopseudomonas palustris hypothetical protein SWALL:Q6N7K3 (EMBL:BX572600) (242 aa); similarity:fasta; SWALL:Q6N7K3 (EMBL:BX572600); Rhodopseudomonas palustris; hypothetical protein; length 242 aa; 66 aa overlap; query 6-71 aa; subject 5-70 aa 216596029671 3 probable transmembrane helices predicted at aa 21-40, 66-85 and 171-193 216596029672 Protein of unknown function DUF262; Region: DUF262; pfam03235 216596029673 Uncharacterized conserved protein [Function unknown]; Region: COG1479 216596029674 Protein of unknown function DUF262; Region: DUF262; pfam03235 216596029675 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 216596029676 Pfam match to entry PF07510.1 DUF1524 216596029677 Pfam match to entry PF03235.3 DUF262 216596029678 HsdM N-terminal domain; Region: HsdM_N; pfam12161 216596029679 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 216596029680 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596029681 S-adenosylmethionine binding site [chemical binding]; other site 216596029682 Pfam match to entry PF02506.4 Methylase_M 216596029683 Pfam match to entry PF02384.5 N6_Mtase 216596029684 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 216596029685 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 216596029686 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 216596029687 Pfam match to entry PF01420.8 Methylase_S 216596029688 FRG domain; Region: FRG; pfam08867 216596029689 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 216596029690 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 216596029691 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 216596029692 ATP binding site [chemical binding]; other site 216596029693 putative Mg++ binding site [ion binding]; other site 216596029694 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 216596029695 Pfam match to entry PF04313.2 HSDR_N 216596029696 Pfam match to entry PF04851.4 ResIII 216596029697 HNH endonuclease; Region: HNH_2; pfam13391 216596029698 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596029699 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596029700 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 216596029701 dimerization interface [polypeptide binding]; other site 216596029702 substrate binding pocket [chemical binding]; other site 216596029703 Pfam match to entry PF00126.10 HTH_1 216596029704 Predicted helix-turn-helix motif with score 1057.000, SD 2.79 at aa 16-37, sequence LHFGRAAAKVRIAQPALSNHVQ 216596029705 Pfam match to entry PF03466.5 LysR_substrate 216596029706 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 216596029707 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 216596029708 putative homodimer interface [polypeptide binding]; other site 216596029709 putative DNA binding site [nucleotide binding]; other site 216596029710 Pfam match to entry PF02735.5 Ku 216596029711 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 216596029712 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 216596029713 putative DNA binding site [nucleotide binding]; other site 216596029714 putative homodimer interface [polypeptide binding]; other site 216596029715 Pfam match to entry PF02735.5 Ku 216596029716 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 216596029717 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 216596029718 Pfam match to entry PF04392.2 DUF534 216596029719 Cache domain; Region: Cache_1; pfam02743 216596029720 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 216596029721 dimerization interface [polypeptide binding]; other site 216596029722 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 216596029723 cyclase homology domain; Region: CHD; cd07302 216596029724 nucleotidyl binding site; other site 216596029725 metal binding site [ion binding]; metal-binding site 216596029726 dimer interface [polypeptide binding]; other site 216596029727 1 probable transmembrane helix predicted at aa 28-50 216596029728 Pfam match to entry PF02743.5 Cache 216596029729 Pfam match to entry PF00672.10 HAMP 216596029730 Pfam match to entry PF00211.9 Guanylate_cyc 216596029731 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 216596029732 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 216596029733 active site 216596029734 DNA binding site [nucleotide binding] 216596029735 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 216596029736 DNA binding site [nucleotide binding] 216596029737 Pfam match to entry PF01068.9 DNA_ligase_A_M 216596029738 Pfam match to entry PF04679.4 DNA_ligase_A_C 216596029739 2 probable transmembrane helices predicted at aa 5-27 and 71-93 216596029740 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 216596029741 Pfam match to entry PF01402.8 HTH_4 216596029742 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 216596029743 conserved cys residue [active] 216596029744 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216596029745 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216596029746 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216596029747 Pfam match to entry PF00165.8 HTH_AraC 216596029748 Pfam match to entry PF00165.8 HTH_AraC 216596029749 Pfam match to entry PF01965.10 DJ-1_PfpI 216596029750 Predicted integral membrane protein [Function unknown]; Region: COG5446 216596029751 6 probable transmembrane helices predicted at aa 7-29, 82-104, 117-136,151-170, 177-196 and 211-233 216596029752 Probable cobalt transporter subunit (CbtB); Region: CbtB; pfam09489 216596029753 1 probable transmembrane helix predicted at aa 26-48 216596029754 nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889 216596029755 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 216596029756 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 216596029757 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 216596029758 Pfam match to entry PF02979.5 NHase_alpha 216596029759 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 216596029760 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 216596029761 Pfam match to entry PF02211.5 NHase_beta 216596029762 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 216596029763 5 probable transmembrane helices predicted at aa 20-42, 54-73, 78-100, 107-126 and 136-158 216596029764 Pfam match to entry PF06496.1 DUF1097 216596029765 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 216596029766 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 216596029767 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 216596029768 Pfam match to entry PF07683.1 CobW_C 216596029769 Pfam match to entry PF02492.7 cobW 216596029770 oxidoreductase; Provisional; Region: PRK06196 216596029771 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 216596029772 putative NAD(P) binding site [chemical binding]; other site 216596029773 active site 216596029774 Pfam match to entry PF00106.11 adh_short 216596029775 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 216596029776 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216596029777 DNA binding site [nucleotide binding] 216596029778 Predicted ATPase [General function prediction only]; Region: COG3903 216596029779 Pfam match to entry PF00486.12 Trans_reg_C 216596029780 Pfam match to entry PF06498.1 Ad_Cycl_assoc 216596029781 Pfam match to entry PF06492.1 DUF1095 216596029782 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 216596029783 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 216596029784 putative NAD(P) binding site [chemical binding]; other site 216596029785 Pfam match to entry PF00107.11 ADH_zinc_N 216596029786 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 216596029787 active site 1 [active] 216596029788 dimer interface [polypeptide binding]; other site 216596029789 hexamer interface [polypeptide binding]; other site 216596029790 active site 2 [active] 216596029791 Pfam match to entry PF01361.9 Tautomerase 216596029792 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 216596029793 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 216596029794 Pfam match to entry PF00561.8 Abhydrolase_1 216596029795 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 216596029796 1 probable transmembrane helix predicted at aa 7-29 216596029797 Pfam match to entry PF00753.13 Lactamase_B 216596029798 DsrE/DsrF-like family; Region: DrsE; pfam02635 216596029799 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 216596029800 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 216596029801 Pfam match to entry PF01408.8 GFO_IDH_MocA 216596029802 Similar to codons 225 to C-terminus of Pseudomonas putida transcriptional regulator, LysR family SWALL:Q88EJ5 (EMBL:AE016790) (300 aa); similarity:fasta; SWALL:Q88EJ5 (EMBL:AE016790); Pseudomonas putida; transcriptional regulator, lysr family; length 300 aa; 64 aa overlap; query 10-73 aa; subject 228-291 aa; putative LysR family transcriptional regulator,pseudogene 216596029803 1 probable transmembrane helix predicted at aa 7-24 216596029804 Pfam match to entry PF03466.5 LysR_substrate 216596029805 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 216596029806 HTH-like domain; Region: HTH_21; pfam13276 216596029807 Integrase core domain; Region: rve; pfam00665 216596029808 Integrase core domain; Region: rve_3; pfam13683 216596029809 Pfam match to entry PF00665.10 rve 216596029810 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 216596029811 DNA-binding interface [nucleotide binding]; DNA binding site 216596029812 Pfam match to entry PF01527.7 Transposase_8 216596029813 Predicted helix-turn-helix motif with score 1510.000, SD 4.33 at aa 22-43, sequence TPVSELCRKHGVSDASIYKWKA 216596029814 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 216596029815 1 probable transmembrane helix predicted at aa 21-43 216596029816 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 216596029817 metal binding site 2 [ion binding]; metal-binding site 216596029818 putative DNA binding helix; other site 216596029819 metal binding site 1 [ion binding]; metal-binding site 216596029820 dimer interface [polypeptide binding]; other site 216596029821 structural Zn2+ binding site [ion binding]; other site 216596029822 Pfam match to entry PF01475.6 FUR 216596029823 Predicted helix-turn-helix motif with score 1158.000, SD 3.13 at aa 54-75, sequence LHAEVLAHGISLSVATVYNALN 216596029824 putative transporter; Provisional; Region: PRK12382 216596029825 12 probable transmembrane helices predicted at aa 7-29, 44-66, 78-100, 115-137,144-166, 170-192, 213-235, 245-264, 271-293, 298-320,333-355 and 360-382 216596029826 Pfam match to entry PF07690.1 MFS_1 216596029827 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 216596029828 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 216596029829 Pfam match to entry PF03446.3 NAD_binding_2 216596029830 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 216596029831 Pfam match to entry PF01261.10 AP_endonuc_2 216596029832 putative aldolase; Validated; Region: PRK08130 216596029833 intersubunit interface [polypeptide binding]; other site 216596029834 active site 216596029835 Zn2+ binding site [ion binding]; other site 216596029836 Pfam match to entry PF00596.9 Aldolase_II 216596029837 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 216596029838 Pfam match to entry PF07005.1 DUF1537 216596029839 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 216596029840 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 216596029841 Pfam match to entry PF03446.3 NAD_binding_2 216596029842 tartrate dehydrogenase; Region: TTC; TIGR02089 216596029843 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 216596029844 Pfam match to entry PF00180.7 Iso_dh 216596029845 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 216596029846 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 216596029847 NAD binding site [chemical binding]; other site 216596029848 catalytic residues [active] 216596029849 Pfam match to entry PF00171.9 Aldedh 216596029850 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216596029851 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 216596029852 NAD(P) binding site [chemical binding]; other site 216596029853 active site 216596029854 Pfam match to entry PF00106.11 adh_short 216596029855 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 216596029856 Pfam match to entry PF03328.3 HpcH_HpaI 216596029857 Cupin domain; Region: Cupin_2; cl17218 216596029858 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 216596029859 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596029860 putative substrate translocation pore; other site 216596029861 12 probable transmembrane helices predicted at aa 21-43, 63-82, 89-111, 121-140,152-174, 179-201, 221-239, 254-276, 283-305, 310-332,345-367 and 372-394 216596029862 Pfam match to entry PF07690.1 MFS_1 216596029863 Pfam match to entry PF00083.10 Sugar_tr 216596029864 Uncharacterized conserved protein [Function unknown]; Region: COG4925 216596029865 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596029866 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596029867 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216596029868 dimerization interface [polypeptide binding]; other site 216596029869 Pfam match to entry PF03466.5 LysR_substrate 216596029870 Pfam match to entry PF00126.10 HTH_1 216596029871 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 216596029872 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 216596029873 tetramerization interface [polypeptide binding]; other site 216596029874 NAD(P) binding site [chemical binding]; other site 216596029875 catalytic residues [active] 216596029876 Pfam match to entry PF00171.9 Aldedh 216596029877 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 216596029878 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 216596029879 NAD binding site [chemical binding]; other site 216596029880 Pfam match to entry PF02826.5 2-Hacid_dh_C 216596029881 Pfam match to entry PF00389.15 2-Hacid_dh 216596029882 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 216596029883 Pfam match to entry PF03758.3 SMP-30 216596029884 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 216596029885 classical (c) SDRs; Region: SDR_c; cd05233 216596029886 NAD(P) binding site [chemical binding]; other site 216596029887 active site 216596029888 Pfam match to entry PF00106.11 adh_short 216596029889 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 216596029890 Pfam match to entry PF03972.3 MmgE_PrpD 216596029891 short chain dehydrogenase; Provisional; Region: PRK06172 216596029892 classical (c) SDRs; Region: SDR_c; cd05233 216596029893 NAD(P) binding site [chemical binding]; other site 216596029894 active site 216596029895 Pfam match to entry PF00106.11 adh_short 216596029896 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216596029897 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216596029898 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596029899 TM-ABC transporter signature motif; other site 216596029900 11 probable transmembrane helices predicted at aa 37-56, 71-93, 95-112, 117-139,141-163, 191-210, 223-242, 252-271, 292-314, 329-351 and 372-394 216596029901 Pfam match to entry PF02653.5 BPD_transp_2 216596029902 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 216596029903 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 216596029904 Walker A/P-loop; other site 216596029905 ATP binding site [chemical binding]; other site 216596029906 Q-loop/lid; other site 216596029907 ABC transporter signature motif; other site 216596029908 Walker B; other site 216596029909 D-loop; other site 216596029910 H-loop/switch region; other site 216596029911 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 216596029912 Pfam match to entry PF00005.11 ABC_tran 216596029913 Pfam match to entry PF00005.11 ABC_tran 216596029914 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 216596029915 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 216596029916 ligand binding site [chemical binding]; other site 216596029917 Pfam match to entry PF00532.8 Peripla_BP_1 216596029918 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 216596029919 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 216596029920 putative NAD(P) binding site [chemical binding]; other site 216596029921 catalytic Zn binding site [ion binding]; other site 216596029922 Pfam match to entry PF00107.11 ADH_zinc_N 216596029923 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 216596029924 RibD C-terminal domain; Region: RibD_C; cl17279 216596029925 Pfam match to entry PF01872.7 RibD_C 216596029926 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 216596029927 13 probable transmembrane helices predicted at aa 15-37, 44-66, 71-93, 105-127,137-159, 164-181, 196-218, 256-278, 317-339, 352-374,389-406, 419-441 and 461-483 216596029928 Pfam match to entry PF01970.6 DUF112 216596029929 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 216596029930 Pfam match to entry PF07331.1 DUF1468 216596029931 4 probable transmembrane helices predicted at aa 20-37, 50-72, 87-116 and 128-150 216596029932 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 216596029933 classical (c) SDRs; Region: SDR_c; cd05233 216596029934 NAD(P) binding site [chemical binding]; other site 216596029935 active site 216596029936 Pfam match to entry PF00106.11 adh_short 216596029937 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 216596029938 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 216596029939 NAD(P) binding site [chemical binding]; other site 216596029940 catalytic residues [active] 216596029941 Pfam match to entry PF00171.9 Aldedh 216596029942 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 216596029943 Pfam match to entry PF03401.3 Bug 216596029944 Transcriptional regulator [Transcription]; Region: IclR; COG1414 216596029945 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 216596029946 Bacterial transcriptional regulator; Region: IclR; pfam01614 216596029947 Predicted helix-turn-helix motif with score 994.000, SD 2.57 at aa 35-56, sequence LTQVEIGKMLGRTTSEIFRMLV 216596029948 Pfam match to entry PF01614.6 IclR 216596029949 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 216596029950 classical (c) SDRs; Region: SDR_c; cd05233 216596029951 NAD(P) binding site [chemical binding]; other site 216596029952 active site 216596029953 Pfam match to entry PF00106.11 adh_short 216596029954 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 216596029955 Pfam match to entry PF03758.3 SMP-30 216596029956 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 216596029957 2-methylcitrate dehydratase; Region: prpD; TIGR02330 216596029958 Pfam match to entry PF03972.3 MmgE_PrpD 216596029959 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 216596029960 substrate binding pocket [chemical binding]; other site 216596029961 membrane-bound complex binding site; other site 216596029962 hinge residues; other site 216596029963 Pfam match to entry PF03401.3 Bug 216596029964 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 216596029965 1 probable transmembrane helix predicted at aa 5-27 216596029966 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 216596029967 6 probable transmembrane helices predicted at aa 17-39, 44-66, 79-101, 121-140,165-187 and 207-229 216596029968 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596029969 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596029970 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 216596029971 putative effector binding pocket; other site 216596029972 putative dimerization interface [polypeptide binding]; other site 216596029973 Pfam match to entry PF03466.5 LysR_substrate 216596029974 Pfam match to entry PF00126.10 HTH_1 216596029975 Predicted helix-turn-helix motif with score 1909.000, SD 5.69 at aa 19-40, sequence RSFTRAAAKVGVSQSALSHTIR 216596029976 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 216596029977 cyclase homology domain; Region: CHD; cd07302 216596029978 nucleotidyl binding site; other site 216596029979 metal binding site [ion binding]; metal-binding site 216596029980 dimer interface [polypeptide binding]; other site 216596029981 Pfam match to entry PF00211.9 Guanylate_cyc 216596029982 6 probable transmembrane helices predicted at aa 104-122, 127-149, 156-175,190-207, 212-234 and 268-290 216596029983 Protein of unknown function (DUF3422); Region: DUF3422; pfam11902 216596029984 2 probable transmembrane helices predicted at aa 349-366 and 381-403 216596029985 1 probable transmembrane helix predicted at aa 36-58 216596029986 4 probable transmembrane helices predicted at aa 3-25, 30-50, 57-79 and 84-103 216596029987 hypothetical protein; Provisional; Region: PRK10621 216596029988 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 216596029989 Pfam match to entry PF01925.8 DUF81 216596029990 6 probable transmembrane helices predicted at aa 15-37, 65-87, 97-116, 136-158,173-195 and 222-244 216596029991 HipA-like N-terminal domain; Region: HipA_N; pfam07805 216596029992 HipA-like C-terminal domain; Region: HipA_C; pfam07804 216596029993 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216596029994 non-specific DNA binding site [nucleotide binding]; other site 216596029995 salt bridge; other site 216596029996 sequence-specific DNA binding site [nucleotide binding]; other site 216596029997 Predicted helix-turn-helix motif with score 1782.000, SD 5.26 at aa 33-54, sequence LTTQELADRAGISRGLLQRIEK 216596029998 Protein of unknown function (DUF982); Region: DUF982; pfam06169 216596029999 Pfam match to entry PF06169.1 DUF982 216596030000 N-terminal 55 residues is similar to the N-terminal 55 residues of Agrobacterium tumefaciens agr_pat_142p SWALL:Q7D3X4 (EMBL:AE007882) (350 aa); similarity:fasta; SWALL:Q7D3X4 (EMBL:AE007882); Agrobacterium tumefaciens; agr_pat_142p; length 350 aa; 55 aa overlap; query 1-55 aa; subject 1-52 aa; conserved hypothetical protein, pseudogene 216596030001 RES domain; Region: RES; pfam08808 216596030002 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 216596030003 Pfam match to entry PF05988.1 DUF899 216596030004 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 216596030005 HSP70 interaction site [polypeptide binding]; other site 216596030006 Pfam match to entry PF00226.14 DnaJ 216596030007 HutD; Region: HutD; pfam05962 216596030008 Pfam match to entry PF05962.1 DUF886 216596030009 urocanate hydratase; Provisional; Region: PRK05414 216596030010 Pfam match to entry PF01175.7 Urocanase 216596030011 N-formylglutamate amidohydrolase; Region: FGase; cl01522 216596030012 Pfam match to entry PF05013.2 FGase 216596030013 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 216596030014 active sites [active] 216596030015 tetramer interface [polypeptide binding]; other site 216596030016 Pfam match to entry PF00221.7 PAL 216596030017 imidazolonepropionase; Validated; Region: PRK09356 216596030018 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 216596030019 active site 216596030020 Pfam match to entry PF01979.7 Amidohydro_1 216596030021 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 216596030022 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 216596030023 active site 216596030024 Pfam match to entry PF01979.7 Amidohydro_1 216596030025 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596030026 DNA-binding site [nucleotide binding]; DNA binding site 216596030027 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 216596030028 UTRA domain; Region: UTRA; pfam07702 216596030029 Pfam match to entry PF00392.9 GntR 216596030030 Pfam match to entry PF07702.1 UTRA 216596030031 Uncharacterized conserved protein [Function unknown]; Region: COG5397 216596030032 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 216596030033 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596030034 DNA-binding site [nucleotide binding]; DNA binding site 216596030035 UTRA domain; Region: UTRA; pfam07702 216596030036 Pfam match to entry PF07702.1 UTRA 216596030037 Pfam match to entry PF00392.9 GntR 216596030038 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 216596030039 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 216596030040 substrate binding pocket [chemical binding]; other site 216596030041 membrane-bound complex binding site; other site 216596030042 hinge residues; other site 216596030043 Pfam match to entry PF00497.8 SBP_bac_3 216596030044 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 216596030045 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596030046 dimer interface [polypeptide binding]; other site 216596030047 conserved gate region; other site 216596030048 putative PBP binding loops; other site 216596030049 ABC-ATPase subunit interface; other site 216596030050 5 probable transmembrane helices predicted at aa 7-29, 33-55, 67-89, 94-116 and 200-222 216596030051 Pfam match to entry PF00528.10 BPD_transp_1 216596030052 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 216596030053 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596030054 dimer interface [polypeptide binding]; other site 216596030055 conserved gate region; other site 216596030056 putative PBP binding loops; other site 216596030057 ABC-ATPase subunit interface; other site 216596030058 Pfam match to entry PF00528.10 BPD_transp_1 216596030059 3 probable transmembrane helices predicted at aa 21-43, 65-87 and 195-217 216596030060 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 216596030061 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 216596030062 Walker A/P-loop; other site 216596030063 ATP binding site [chemical binding]; other site 216596030064 Q-loop/lid; other site 216596030065 ABC transporter signature motif; other site 216596030066 Walker B; other site 216596030067 D-loop; other site 216596030068 H-loop/switch region; other site 216596030069 Pfam match to entry PF00005.11 ABC_tran 216596030070 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 216596030071 active sites [active] 216596030072 tetramer interface [polypeptide binding]; other site 216596030073 Pfam match to entry PF00221.7 PAL 216596030074 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 216596030075 1 probable transmembrane helix predicted at aa 41-63 216596030076 cytochrome c nitrite reductase, pentaheme subunit; Region: cyt_nit_nrfB; TIGR03146 216596030077 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 216596030078 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 216596030079 heme-binding residues [chemical binding]; other site 216596030080 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216596030081 binding surface 216596030082 Tetratricopeptide repeat; Region: TPR_16; pfam13432 216596030083 TPR motif; other site 216596030084 Pfam match to entry PF00515.12 TPR 216596030085 Pfam match to entry PF00515.12 TPR 216596030086 Pfam match to entry PF00515.12 TPR 216596030087 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 216596030088 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216596030089 motif II; other site 216596030090 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 216596030091 Sulfatase; Region: Sulfatase; pfam00884 216596030092 Pfam match to entry PF00884.10 Sulfatase 216596030093 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 216596030094 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216596030095 dimer interface [polypeptide binding]; other site 216596030096 phosphorylation site [posttranslational modification] 216596030097 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596030098 ATP binding site [chemical binding]; other site 216596030099 Mg2+ binding site [ion binding]; other site 216596030100 G-X-G motif; other site 216596030101 1 probable transmembrane helix predicted at aa 348-370 216596030102 Pfam match to entry PF00512.10 HisKA 216596030103 Pfam match to entry PF02518.9 HATPase_c 216596030104 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 216596030105 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596030106 active site 216596030107 phosphorylation site [posttranslational modification] 216596030108 intermolecular recognition site; other site 216596030109 dimerization interface [polypeptide binding]; other site 216596030110 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 216596030111 DNA binding residues [nucleotide binding] 216596030112 dimerization interface [polypeptide binding]; other site 216596030113 Pfam match to entry PF00072.10 Response_reg 216596030114 Pfam match to entry PF00196.8 GerE 216596030115 Predicted helix-turn-helix motif with score 1207.000, SD 3.30 at aa 156-177, sequence RLNKQIAYALGISERTVKVHRH 216596030116 Response regulator receiver domain; Region: Response_reg; pfam00072 216596030117 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596030118 active site 216596030119 phosphorylation site [posttranslational modification] 216596030120 intermolecular recognition site; other site 216596030121 dimerization interface [polypeptide binding]; other site 216596030122 Pfam match to entry PF00072.10 Response_reg 216596030123 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 216596030124 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 216596030125 active site 216596030126 6 probable transmembrane helices predicted at aa 13-35, 79-101, 108-130,150-167, 179-201 and 206-223 216596030127 Pfam match to entry PF01569.9 PAP2 216596030128 Predicted membrane protein [Function unknown]; Region: COG4280 216596030129 7 probable transmembrane helices predicted at aa 10-32, 44-66, 70-87, 123-145,155-177, 189-206 and 216-235 216596030130 2 probable transmembrane helices predicted at aa 12-34 and 44-66 216596030131 HipA N-terminal domain; Region: Couple_hipA; pfam13657 216596030132 HipA-like N-terminal domain; Region: HipA_N; pfam07805 216596030133 HipA-like C-terminal domain; Region: HipA_C; pfam07804 216596030134 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 216596030135 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216596030136 non-specific DNA binding site [nucleotide binding]; other site 216596030137 salt bridge; other site 216596030138 sequence-specific DNA binding site [nucleotide binding]; other site 216596030139 Predicted helix-turn-helix motif with score 1381.000, SD 3.89 at aa 29-50, sequence IAVADLAVRAGTSPSTVARLEK 216596030140 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 216596030141 Mechanosensitive ion channel; Region: MS_channel; pfam00924 216596030142 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 216596030143 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 216596030144 ligand binding site [chemical binding]; other site 216596030145 flexible hinge region; other site 216596030146 Pfam match to entry PF00027.13 cNMP_binding 216596030147 Pfam match to entry PF00924.8 MS_channel 216596030148 4 probable transmembrane helices predicted at aa 15-34, 41-63, 83-103 and 116-138 216596030149 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 216596030150 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 216596030151 6 probable transmembrane helices predicted at aa 12-34, 184-206, 227-249,259-281, 286-308 and 349-366 216596030152 Pfam match to entry PF01061.8 ABC2_membrane 216596030153 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 216596030154 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 216596030155 6 probable transmembrane helices predicted at aa 27-49, 195-217, 238-260,275-297, 304-326 and 364-383 216596030156 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 216596030157 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 216596030158 HlyD family secretion protein; Region: HlyD_3; pfam13437 216596030159 Pfam match to entry PF00529.8 HlyD 216596030160 1 probable transmembrane helix predicted at aa 25-47 216596030161 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 216596030162 hydroxyglutarate oxidase; Provisional; Region: PRK11728 216596030163 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 216596030164 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 216596030165 Pfam match to entry PF01571.8 GCV_T 216596030166 Pfam match to entry PF01266.8 DAO 216596030167 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 216596030168 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216596030169 non-specific DNA binding site [nucleotide binding]; other site 216596030170 salt bridge; other site 216596030171 sequence-specific DNA binding site [nucleotide binding]; other site 216596030172 Methyltransferase domain; Region: Methyltransf_31; pfam13847 216596030173 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596030174 S-adenosylmethionine binding site [chemical binding]; other site 216596030175 Predicted helix-turn-helix motif with score 1473.000, SD 4.20 at aa 47-68, sequence MSVQDLAKKTGIKERYLREWLS 216596030176 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 216596030177 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216596030178 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216596030179 Pfam match to entry PF00165.8 HTH_AraC 216596030180 Pfam match to entry PF00165.8 HTH_AraC 216596030181 Predicted helix-turn-helix motif with score 1220.000, SD 3.34 at aa 246-267, sequence LPVSELAGIVGLSRAHFSRSFA 216596030182 Pfam match to entry PF02311.7 AraC_binding 216596030183 alpha-galactosidase; Provisional; Region: PRK15076 216596030184 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 216596030185 NAD binding site [chemical binding]; other site 216596030186 sugar binding site [chemical binding]; other site 216596030187 divalent metal binding site [ion binding]; other site 216596030188 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 216596030189 dimer interface [polypeptide binding]; other site 216596030190 Pfam match to entry PF02056.5 Glyco_hydro_4 216596030191 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 216596030192 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 216596030193 Pfam match to entry PF00496.9 SBP_bac_5 216596030194 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 216596030195 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596030196 dimer interface [polypeptide binding]; other site 216596030197 conserved gate region; other site 216596030198 putative PBP binding loops; other site 216596030199 ABC-ATPase subunit interface; other site 216596030200 6 probable transmembrane helices predicted at aa 5-27, 109-131, 144-166,196-213, 277-299 and 303-325 216596030201 Pfam match to entry PF00528.10 BPD_transp_1 216596030202 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 216596030203 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596030204 dimer interface [polypeptide binding]; other site 216596030205 conserved gate region; other site 216596030206 putative PBP binding loops; other site 216596030207 ABC-ATPase subunit interface; other site 216596030208 6 probable transmembrane helices predicted at aa 39-61, 174-196, 231-253,290-312, 316-335 and 342-364 216596030209 Pfam match to entry PF00528.10 BPD_transp_1 216596030210 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 216596030211 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596030212 Walker A/P-loop; other site 216596030213 ATP binding site [chemical binding]; other site 216596030214 Q-loop/lid; other site 216596030215 ABC transporter signature motif; other site 216596030216 Walker B; other site 216596030217 D-loop; other site 216596030218 H-loop/switch region; other site 216596030219 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596030220 Walker A/P-loop; other site 216596030221 ATP binding site [chemical binding]; other site 216596030222 Q-loop/lid; other site 216596030223 ABC transporter signature motif; other site 216596030224 Walker B; other site 216596030225 D-loop; other site 216596030226 H-loop/switch region; other site 216596030227 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216596030228 Pfam match to entry PF00005.11 ABC_tran 216596030229 Pfam match to entry PF00005.11 ABC_tran 216596030230 alpha-galactosidase; Provisional; Region: PRK15076 216596030231 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 216596030232 NAD binding site [chemical binding]; other site 216596030233 sugar binding site [chemical binding]; other site 216596030234 divalent metal binding site [ion binding]; other site 216596030235 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 216596030236 dimer interface [polypeptide binding]; other site 216596030237 Pfam match to entry PF02056.5 Glyco_hydro_4 216596030238 Domain of unknown function DUF20; Region: UPF0118; pfam01594 216596030239 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 216596030240 Pfam match to entry PF01594.6 UPF0118 216596030241 7 probable transmembrane helices predicted at aa 59-81, 101-123, 208-230,266-288, 301-323, 328-350 and 363-385 216596030242 similarity:fasta; SWALL:Q92Y40 (EMBL:AE007290); Rhizobium meliloti; putative MrcB penicillin binding protein b; mrcB; length 781 aa; 782 aa overlap; query 2-764 aa; subject 1-781 aa; putative cell division (penicillin binding family) protein, pseudogene 216596030243 Pfam match to entry PF00912.9 Transgly 216596030244 Pfam match to entry PF00912.9 Transgly 216596030245 Pfam match to entry PF00905.9 Transpeptidase 216596030246 Peptidase M4 family containing mostly uncharacterized proteins; Region: M4_uncharacterized; cd09598 216596030247 Zn binding site [ion binding]; other site 216596030248 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 216596030249 TfuA-like protein; Region: TfuA; pfam07812 216596030250 Uncharacterized conserved protein [Function unknown]; Region: COG1944 216596030251 YcaO-like family; Region: YcaO; pfam02624 216596030252 Pfam match to entry PF02624.4 YcaO 216596030253 cyclase homology domain; Region: CHD; cd07302 216596030254 dimer interface [polypeptide binding]; other site 216596030255 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 216596030256 nucleotidyl binding site; other site 216596030257 metal binding site [ion binding]; metal-binding site 216596030258 AAA ATPase domain; Region: AAA_16; pfam13191 216596030259 Pfam match to entry PF06492.1 DUF1095 216596030260 Pfam match to entry PF06498.1 Ad_Cycl_assoc 216596030261 similarity:fasta; SWALL:Q989F3 (EMBL:AP003009); Rhizobium loti; alpha-galactosidase; length 461 aa; 191 aa overlap; query 18-208 aa; subject 271-461 aa; putative alpha-galactosidase, pseudogene 216596030262 Pfam match to entry PF02056.5 Glyco_hydro_4 216596030263 Protein of unknown function (DUF982); Region: DUF982; pfam06169 216596030264 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 216596030265 dimer interface [polypeptide binding]; other site 216596030266 Pfam match to entry PF06983.1 3-dmu-9_3-mt 216596030267 Transglycosylase; Region: Transgly; pfam00912 216596030268 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 216596030269 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 216596030270 BA14K-like protein; Region: BA14K; pfam07886 216596030271 1 probable transmembrane helix predicted at aa 135-157 216596030272 Pfam match to entry PF00912.9 Transgly 216596030273 Pfam match to entry PF00905.9 Transpeptidase 216596030274 4 probable transmembrane helices predicted at aa 164-186, 201-223, 230-252 and 285-307 216596030275 1 probable transmembrane helix predicted at aa 38-60 216596030276 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 216596030277 4 probable transmembrane helices predicted at aa 13-32, 42-64, 76-98 and 103-125 216596030278 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 216596030279 ligand binding site [chemical binding]; other site 216596030280 1 probable transmembrane helix predicted at aa 23-45 216596030281 Pfam match to entry PF00691.7 OmpA 216596030282 Staphylococcal nuclease homologues; Region: SNc; smart00318 216596030283 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 216596030284 Catalytic site; other site 216596030285 Pfam match to entry PF00565.7 SNase 216596030286 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 216596030287 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 216596030288 metal binding site [ion binding]; metal-binding site 216596030289 active site 216596030290 I-site; other site 216596030291 Pfam match to entry PF00990.8 GGDEF 216596030292 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 216596030293 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 216596030294 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 216596030295 Pfam match to entry PF05406.2 WGR 216596030296 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 216596030297 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216596030298 non-specific DNA binding site [nucleotide binding]; other site 216596030299 salt bridge; other site 216596030300 sequence-specific DNA binding site [nucleotide binding]; other site 216596030301 Pfam match to entry PF01381.9 HTH_3 216596030302 Predicted helix-turn-helix motif with score 1667.000, SD 4.86 at aa 109-130, sequence MTQEQVADLAGISRPRYRDIET 216596030303 HipA N-terminal domain; Region: Couple_hipA; pfam13657 216596030304 HipA-like N-terminal domain; Region: HipA_N; pfam07805 216596030305 HipA-like C-terminal domain; Region: HipA_C; pfam07804 216596030306 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 216596030307 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 216596030308 Walker A motif; other site 216596030309 ATP binding site [chemical binding]; other site 216596030310 Walker B motif; other site 216596030311 Pfam match to entry PF02534.4 TraG 216596030312 3 probable transmembrane helices predicted at aa 13-35, 40-62 and 75-97 216596030313 Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768 216596030314 MobA/MobL family; Region: MobA_MobL; pfam03389 216596030315 AAA domain; Region: AAA_30; pfam13604 216596030316 Family description; Region: UvrD_C_2; pfam13538 216596030317 Pfam match to entry PF03389.3 MobA_MobL 216596030318 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 216596030319 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596030320 Walker A/P-loop; other site 216596030321 ATP binding site [chemical binding]; other site 216596030322 Q-loop/lid; other site 216596030323 ABC transporter signature motif; other site 216596030324 Walker B; other site 216596030325 D-loop; other site 216596030326 H-loop/switch region; other site 216596030327 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216596030328 Pfam match to entry PF00005.11 ABC_tran 216596030329 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 216596030330 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596030331 Walker A/P-loop; other site 216596030332 ATP binding site [chemical binding]; other site 216596030333 Q-loop/lid; other site 216596030334 ABC transporter signature motif; other site 216596030335 Walker B; other site 216596030336 D-loop; other site 216596030337 H-loop/switch region; other site 216596030338 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 216596030339 Pfam match to entry PF00005.11 ABC_tran 216596030340 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 216596030341 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596030342 dimer interface [polypeptide binding]; other site 216596030343 conserved gate region; other site 216596030344 putative PBP binding loops; other site 216596030345 ABC-ATPase subunit interface; other site 216596030346 Pfam match to entry PF00528.10 BPD_transp_1 216596030347 6 probable transmembrane helices predicted at aa 13-35, 80-102, 109-131,136-153, 189-211 and 244-266 216596030348 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 216596030349 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596030350 dimer interface [polypeptide binding]; other site 216596030351 conserved gate region; other site 216596030352 putative PBP binding loops; other site 216596030353 ABC-ATPase subunit interface; other site 216596030354 Pfam match to entry PF00528.10 BPD_transp_1 216596030355 6 probable transmembrane helices predicted at aa 13-35, 114-136, 149-171,202-224, 260-282 and 302-324 216596030356 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 216596030357 substrate binding site [chemical binding]; other site 216596030358 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 216596030359 Pfam match to entry PF00496.9 SBP_bac_5 216596030360 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 216596030361 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 216596030362 Pfam match to entry PF06964.1 Alpha-L-AF_C 216596030363 Predicted transcriptional regulator [Transcription]; Region: COG4189 216596030364 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 216596030365 dimerization interface [polypeptide binding]; other site 216596030366 putative DNA binding site [nucleotide binding]; other site 216596030367 putative Zn2+ binding site [ion binding]; other site 216596030368 Pfam match to entry PF01022.8 HTH_5 216596030369 Predicted helix-turn-helix motif with score 1308.000, SD 3.64 at aa 39-60, sequence MNINDIARALSLPQSTVATGIQ 216596030370 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 216596030371 Pfam match to entry PF03150.3 CCP_MauG 216596030372 Predicted helix-turn-helix motif with score 1141.000, SD 3.07 at aa 13-34, sequence LRQSSAATAVGLHPGPMSRTEA 216596030373 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 216596030374 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 216596030375 Pfam match to entry PF04185.2 Phosphoesterase 216596030376 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 216596030377 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 216596030378 Bacterial transcriptional regulator; Region: IclR; pfam01614 216596030379 Pfam match to entry PF01614.6 IclR 216596030380 Predicted helix-turn-helix motif with score 1131.000, SD 3.04 at aa 27-48, sequence LSIAEAAKLTELDRATVRRSLL 216596030381 Coenzyme A transferase; Region: CoA_trans; cl17247 216596030382 Pfam match to entry PF01144.9 CoA_trans 216596030383 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 216596030384 Pfam match to entry PF01144.9 CoA_trans 216596030385 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 216596030386 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 216596030387 dimer interface [polypeptide binding]; other site 216596030388 active site 216596030389 Pfam match to entry PF00108.10 Thiolase_N 216596030390 Pfam match to entry PF02803.5 Thiolase_C 216596030391 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 216596030392 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216596030393 Coenzyme A binding pocket [chemical binding]; other site 216596030394 Pfam match to entry PF00583.9 Acetyltransf_1 216596030395 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 216596030396 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 216596030397 Pfam match to entry PF01058.9 Oxidored_q6 216596030398 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 216596030399 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 216596030400 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 216596030401 Pfam match to entry PF00346.7 Complex1_49kDa 216596030402 hydrogenase 4 subunit F; Validated; Region: PRK06458 216596030403 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 216596030404 13 probable transmembrane helices predicted at aa 10-32, 39-58, 73-95, 108-127,131-153, 165-187, 216-238, 251-268, 278-300, 320-342,386-408, 415-437 and 457-479 216596030405 Pfam match to entry PF00361.7 Oxidored_q1 216596030406 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899 216596030407 7 probable transmembrane helices predicted at aa 4-26, 33-55, 60-82, 94-116,131-148, 155-172 and 177-199 216596030408 NADH dehydrogenase; Region: NADHdh; cl00469 216596030409 Pfam match to entry PF00146.9 NADHdh 216596030410 8 probable transmembrane helices predicted at aa 7-29, 73-95, 102-124, 144-166,173-192, 225-247, 260-282 and 297-314 216596030411 hydrogenase 4 subunit B; Validated; Region: PRK06521 216596030412 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 216596030413 16 probable transmembrane helices predicted at aa 4-26, 38-60, 80-102, 115-132,136-153, 165-187, 207-229, 242-264, 274-296, 303-325,340-362, 383-405, 431-453, 474-496, 531-553 and 654-672 216596030414 Pfam match to entry PF00361.7 Oxidored_q1 216596030415 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 216596030416 Pfam match to entry PF00108.10 Thiolase_N 216596030417 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 216596030418 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596030419 putative substrate translocation pore; other site 216596030420 12 probable transmembrane helices predicted at aa 45-67, 82-104, 111-130,140-162, 169-191, 201-220, 252-274, 284-306, 313-335,341-363, 375-397 and 407-429 216596030421 Pfam match to entry PF07690.1 MFS_1 216596030422 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 216596030423 Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or...; Region: APPLE_Factor_XI_like; cd01100 216596030424 putative binding site; other site 216596030425 Caspase domain; Region: Peptidase_C14; pfam00656 216596030426 Pfam match to entry PF00024.12 PAN 216596030427 Pfam match to entry PF00656.9 Peptidase_C14 216596030428 1 probable transmembrane helix predicted at aa 12-34 216596030429 1 probable transmembrane helix predicted at aa 27-49 216596030430 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 216596030431 classical (c) SDRs; Region: SDR_c; cd05233 216596030432 NAD(P) binding site [chemical binding]; other site 216596030433 active site 216596030434 Pfam match to entry PF00106.11 adh_short 216596030435 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 216596030436 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 216596030437 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 216596030438 active site 216596030439 catalytic site [active] 216596030440 Pfam match to entry PF02922.6 Isoamylase_N 216596030441 Pfam match to entry PF00128.11 Alpha-amylase 216596030442 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 216596030443 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 216596030444 active site 216596030445 DNA binding site [nucleotide binding] 216596030446 Int/Topo IB signature motif; other site 216596030447 catalytic residues [active] 216596030448 Pfam match to entry PF01028.9 Topoisom_I 216596030449 Similar to C-terminus from codon 550 of Rhizobium sp. ATP-dependent DNA ligase SWALL:Q6W1H3 (EMBL:AY316747) (850 aa); similarity:fasta; SWALL:Q6W1H3 (EMBL:AY316747); Rhizobium sp.; ATP-dependent DNA ligase; length 850 aa; 289 aa overlap; query 3-291 aa; subject 553-839 aa; putative ATP-dependent DNA ligase, pseudogene 216596030450 GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039 216596030451 glutathione s-transferase; Provisional; Region: PTZ00057 216596030452 GSH binding site (G-site) [chemical binding]; other site 216596030453 C-terminal domain interface [polypeptide binding]; other site 216596030454 dimer interface [polypeptide binding]; other site 216596030455 C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192 216596030456 dimer interface [polypeptide binding]; other site 216596030457 N-terminal domain interface [polypeptide binding]; other site 216596030458 substrate binding pocket (H-site) [chemical binding]; other site 216596030459 Pfam match to entry PF00043.11 GST_C 216596030460 Protein of unknown function (DUF3175); Region: DUF3175; pfam11373 216596030461 Codons 14 to the C-terminus are similar to codons 142 to the C-terminus of Mesembryanthemum crystallinum MipD protein SWALL:Q40259 (EMBL:U26537) (285 aa); similarity:fasta; SWALL:Q40259 (EMBL:U26537); Mesembryanthemum crystallinum; MipD protein; length 285 aa; 138 aa overlap; query 15-148 aa; subject 142-267 aa; conserved hypothetical protein, pseudogene 216596030462 PAS fold; Region: PAS_4; pfam08448 216596030463 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 216596030464 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 216596030465 GAF domain; Region: GAF; pfam01590 216596030466 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 216596030467 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216596030468 dimer interface [polypeptide binding]; other site 216596030469 phosphorylation site [posttranslational modification] 216596030470 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596030471 ATP binding site [chemical binding]; other site 216596030472 Mg2+ binding site [ion binding]; other site 216596030473 G-X-G motif; other site 216596030474 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 216596030475 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596030476 active site 216596030477 phosphorylation site [posttranslational modification] 216596030478 intermolecular recognition site; other site 216596030479 dimerization interface [polypeptide binding]; other site 216596030480 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 216596030481 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596030482 active site 216596030483 phosphorylation site [posttranslational modification] 216596030484 intermolecular recognition site; other site 216596030485 dimerization interface [polypeptide binding]; other site 216596030486 Pfam match to entry PF00072.10 Response_reg 216596030487 Pfam match to entry PF00072.10 Response_reg 216596030488 Pfam match to entry PF02518.9 HATPase_c 216596030489 Pfam match to entry PF00512.10 HisKA 216596030490 Pfam match to entry PF01590.11 GAF 216596030491 Pfam match to entry PF00785.11 PAC 216596030492 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 216596030493 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 216596030494 Fe-S cluster binding site [ion binding]; other site 216596030495 active site 216596030496 Pfam match to entry PF03167.6 UDG 216596030497 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 216596030498 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157 216596030499 putative active site [active] 216596030500 catalytic site [active] 216596030501 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163 216596030502 putative active site [active] 216596030503 catalytic site [active] 216596030504 2 probable transmembrane helices predicted at aa 20-42 and 49-71 216596030505 Pfam match to entry PF00614.9 PLDc 216596030506 Pfam match to entry PF00614.9 PLDc 216596030507 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 216596030508 putative catalytic site [active] 216596030509 putative metal binding site [ion binding]; other site 216596030510 putative phosphate binding site [ion binding]; other site 216596030511 Pfam match to entry PF03372.7 Exo_endo_phos 216596030512 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 216596030513 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 216596030514 substrate binding pocket [chemical binding]; other site 216596030515 catalytic triad [active] 216596030516 Pfam match to entry PF00135.13 COesterase 216596030517 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216596030518 PAS domain; Region: PAS_9; pfam13426 216596030519 putative active site [active] 216596030520 heme pocket [chemical binding]; other site 216596030521 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 216596030522 HWE histidine kinase; Region: HWE_HK; smart00911 216596030523 Pfam match to entry PF07536.2 HWE_HK 216596030524 Pfam match to entry PF00785.11 PAC 216596030525 Pfam match to entry PF00989.11 PAS 216596030526 hypothetical protein; Provisional; Region: PRK13559 216596030527 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216596030528 putative active site [active] 216596030529 heme pocket [chemical binding]; other site 216596030530 HWE histidine kinase; Region: HWE_HK; smart00911 216596030531 Pfam match to entry PF00989.11 PAS 216596030532 Pfam match to entry PF00785.11 PAC 216596030533 Pfam match to entry PF07536.2 HWE_HK 216596030534 Protein of unknown function (DUF982); Region: DUF982; pfam06169 216596030535 Pfam match to entry PF06169.1 DUF982 216596030536 2 probable transmembrane helices predicted at aa 53-75 and 166-188 216596030537 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 216596030538 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 216596030539 Pfam match to entry PF01566.8 Nramp 216596030540 10 probable transmembrane helices predicted at aa 60-82, 95-117, 132-154,166-188, 203-221, 258-280, 306-328, 349-371, 381-400 and 413-435 216596030541 Domain of unknown function (DUF305); Region: DUF305; cl17794 216596030542 Pfam match to entry PF03713.3 DUF305 216596030543 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 216596030544 dimerization interface [polypeptide binding]; other site 216596030545 Pfam match to entry PF03860.5 DUF326 216596030546 Pfam match to entry PF03860.5 DUF326 216596030547 Pfam match to entry PF03860.5 DUF326 216596030548 1 probable transmembrane helix predicted at aa 13-35 216596030549 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 216596030550 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 216596030551 DNA binding residues [nucleotide binding] 216596030552 dimer interface [polypeptide binding]; other site 216596030553 copper binding site [ion binding]; other site 216596030554 Pfam match to entry PF00376.9 MerR 216596030555 Predicted helix-turn-helix motif with score 1549.000, SD 4.46 at aa 1-22, sequence MNIGEAAKASGVSAKMIRYYEQ 216596030556 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 216596030557 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 216596030558 metal-binding site [ion binding] 216596030559 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 216596030560 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 216596030561 metal-binding site [ion binding] 216596030562 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 216596030563 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 216596030564 motif II; other site 216596030565 8 probable transmembrane helices predicted at aa 169-191, 211-233, 246-268,273-295, 427-449, 454-476, 769-791 and 795-817 216596030566 Predicted helix-turn-helix motif with score 1458.000, SD 4.15 at aa 747-768, sequence GDLTAVVRAVGLSRATIRNIKQ 216596030567 Pfam match to entry PF00702.10 Hydrolase 216596030568 Pfam match to entry PF00122.7 E1-E2_ATPase 216596030569 Pfam match to entry PF00403.12 HMA 216596030570 Pfam match to entry PF00403.12 HMA 216596030571 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 216596030572 cyclase homology domain; Region: CHD; cd07302 216596030573 nucleotidyl binding site; other site 216596030574 metal binding site [ion binding]; metal-binding site 216596030575 dimer interface [polypeptide binding]; other site 216596030576 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 216596030577 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 216596030578 dimer interface [polypeptide binding]; other site 216596030579 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 216596030580 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 216596030581 homodimer interface [polypeptide binding]; other site 216596030582 active site 216596030583 TDP-binding site; other site 216596030584 acceptor substrate-binding pocket; other site 216596030585 Pfam match to entry PF00201.8 UDPGT 216596030586 Pfam match to entry PF03033.7 Glyco_transf_28 216596030587 1 probable transmembrane helix predicted at aa 13-35 216596030588 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 216596030589 Pfam match to entry PF02705.5 K_trans 216596030590 12 probable transmembrane helices predicted at aa 21-43, 63-85, 112-134,149-168, 175-197, 222-244, 257-279, 294-316, 353-370,374-396, 403-425 and 435-454 216596030591 N-terminus to codon 125 similar to codons 955 to 1080 of Vibrio cholerae DNA polymerase III alpha subunit DnaE SWALL:DP3A_VIBCH (SWALL:P52022) (1159 aa), and N-terminus to codon 171 similar to codon 905 to 1075 of Rhizobium meliloti DnaE3 putative DNA polymerase III alpha chain DnaE3 SWALL:Q92ZJ6 (EMBL:AE007239) (1087 aa); similarity:fasta; SWALL:DP3A_VIBCH (SWALL:P52022); Vibrio cholerae; DNA polymerase iii alpha subunit; dnaE; length 1159 aa; 117 aa overlap; query 9-121 aa; subject 958-1074 aa; similarity:fasta; SWALL:Q92ZJ6 (EMBL:AE007239); Rhizobium meliloti; Dnae3 putative DNA polymerase iii alpha chain; dnae3; length 1087 aa; 169 aa overlap; query 1-169 aa; subject 904-1072 aa; putative DNA polymerase III alpha subunit,pseudogene 216596030592 Pfam match to entry PF01336.9 tRNA_anti 216596030593 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 216596030594 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 216596030595 Int/Topo IB signature motif; other site 216596030596 Pfam match to entry PF02899.5 Phage_integr_N 216596030597 Pfam match to entry PF00589.8 Phage_integrase 216596030598 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 216596030599 Putative transposase; Region: Y2_Tnp; pfam04986 216596030600 Pfam match to entry PF04986.3 Transposase_32 216596030601 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 216596030602 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 216596030603 ligand binding site [chemical binding]; other site 216596030604 dimer interface [polypeptide binding]; other site 216596030605 Pfam match to entry PF00903.11 Glyoxalase 216596030606 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 216596030607 INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190 216596030608 Int/Topo IB signature motif; other site 216596030609 Pfam match to entry PF00589.8 Phage_integrase 216596030610 Pfam match to entry PF02899.5 Phage_integr_N 216596030611 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 216596030612 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 216596030613 active site 216596030614 DNA binding site [nucleotide binding] 216596030615 Int/Topo IB signature motif; other site 216596030616 Pfam match to entry PF00589.8 Phage_integrase 216596030617 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 216596030618 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 216596030619 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 216596030620 active site 216596030621 DNA binding site [nucleotide binding] 216596030622 Int/Topo IB signature motif; other site 216596030623 Pfam match to entry PF00589.8 Phage_integrase 216596030624 Pfam match to entry PF02899.5 Phage_integr_N 216596030625 Pfam match to entry PF02899.5 Phage_integr_N 216596030626 Protein of unknown function (DUF982); Region: DUF982; pfam06169 216596030627 Pfam match to entry PF06169.1 DUF982 216596030628 Transposase; Region: DEDD_Tnp_IS110; pfam01548 216596030629 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 216596030630 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 216596030631 Pfam match to entry PF02371.5 Transposase_20 216596030632 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 216596030633 cyclase homology domain; Region: CHD; cd07302 216596030634 nucleotidyl binding site; other site 216596030635 metal binding site [ion binding]; metal-binding site 216596030636 dimer interface [polypeptide binding]; other site 216596030637 Pfam match to entry PF00211.9 Guanylate_cyc 216596030638 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 216596030639 1 probable transmembrane helix predicted at aa 26-48 216596030640 Response regulator receiver domain; Region: Response_reg; pfam00072 216596030641 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596030642 active site 216596030643 phosphorylation site [posttranslational modification] 216596030644 intermolecular recognition site; other site 216596030645 dimerization interface [polypeptide binding]; other site 216596030646 Pfam match to entry PF00072.10 Response_reg 216596030647 Transcriptional regulators [Transcription]; Region: FadR; COG2186 216596030648 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596030649 DNA-binding site [nucleotide binding]; DNA binding site 216596030650 FCD domain; Region: FCD; pfam07729 216596030651 Pfam match to entry PF00392.9 GntR 216596030652 Predicted helix-turn-helix motif with score 1003.000, SD 2.60 at aa 34-55, sequence PAERELMAALGVGRSTIREAIR 216596030653 hypothetical protein; Provisional; Region: PRK05968 216596030654 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 216596030655 homodimer interface [polypeptide binding]; other site 216596030656 substrate-cofactor binding pocket; other site 216596030657 pyridoxal 5'-phosphate binding site [chemical binding]; other site 216596030658 catalytic residue [active] 216596030659 Pfam match to entry PF01053.8 Cys_Met_Meta_PP 216596030660 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 216596030661 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 216596030662 Pfam match to entry PF01547.11 SBP_bac_1 216596030663 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596030664 dimer interface [polypeptide binding]; other site 216596030665 conserved gate region; other site 216596030666 putative PBP binding loops; other site 216596030667 ABC-ATPase subunit interface; other site 216596030668 6 probable transmembrane helices predicted at aa 28-50, 89-111, 123-145,179-201, 221-243 and 281-303 216596030669 Pfam match to entry PF00528.10 BPD_transp_1 216596030670 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216596030671 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596030672 dimer interface [polypeptide binding]; other site 216596030673 conserved gate region; other site 216596030674 putative PBP binding loops; other site 216596030675 ABC-ATPase subunit interface; other site 216596030676 6 probable transmembrane helices predicted at aa 13-30, 73-95, 104-126,141-163, 186-208 and 244-266 216596030677 Pfam match to entry PF00528.10 BPD_transp_1 216596030678 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 216596030679 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 216596030680 Walker A/P-loop; other site 216596030681 ATP binding site [chemical binding]; other site 216596030682 Q-loop/lid; other site 216596030683 ABC transporter signature motif; other site 216596030684 Walker B; other site 216596030685 D-loop; other site 216596030686 H-loop/switch region; other site 216596030687 TOBE domain; Region: TOBE_2; pfam08402 216596030688 Pfam match to entry PF00005.11 ABC_tran 216596030689 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 216596030690 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 216596030691 active site 216596030692 metal binding site [ion binding]; metal-binding site 216596030693 hexamer interface [polypeptide binding]; other site 216596030694 Pfam match to entry PF00149.12 Metallophos 216596030695 peptidase T; Region: peptidase-T; TIGR01882 216596030696 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 216596030697 metal binding site [ion binding]; metal-binding site 216596030698 dimer interface [polypeptide binding]; other site 216596030699 Pfam match to entry PF01546.13 Peptidase_M20 216596030700 Pfam match to entry PF07687.1 M20_dimer 216596030701 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 216596030702 Pfam match to entry PF07486.1 Hydrolase_2 216596030703 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 216596030704 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 216596030705 Walker A/P-loop; other site 216596030706 ATP binding site [chemical binding]; other site 216596030707 Q-loop/lid; other site 216596030708 ABC transporter signature motif; other site 216596030709 Walker B; other site 216596030710 D-loop; other site 216596030711 H-loop/switch region; other site 216596030712 TOBE-like domain; Region: TOBE_3; pfam12857 216596030713 Pfam match to entry PF00005.11 ABC_tran 216596030714 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 216596030715 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596030716 dimer interface [polypeptide binding]; other site 216596030717 conserved gate region; other site 216596030718 putative PBP binding loops; other site 216596030719 ABC-ATPase subunit interface; other site 216596030720 Pfam match to entry PF00528.10 BPD_transp_1 216596030721 5 probable transmembrane helices predicted at aa 21-43, 74-96, 109-131, 146-165 and 250-272 216596030722 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 216596030723 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596030724 dimer interface [polypeptide binding]; other site 216596030725 conserved gate region; other site 216596030726 putative PBP binding loops; other site 216596030727 ABC-ATPase subunit interface; other site 216596030728 Pfam match to entry PF00528.10 BPD_transp_1 216596030729 6 probable transmembrane helices predicted at aa 20-42, 71-93, 106-128,143-165, 191-213 and 251-273 216596030730 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 216596030731 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 216596030732 substrate binding pocket [chemical binding]; other site 216596030733 membrane-bound complex binding site; other site 216596030734 hinge residues; other site 216596030735 Pfam match to entry PF01547.11 SBP_bac_1 216596030736 Porin subfamily; Region: Porin_2; pfam02530 216596030737 Pfam match to entry PF02530.4 Porin_2 216596030738 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 216596030739 active site 216596030740 phosphorylation site [posttranslational modification] 216596030741 Pfam match to entry PF00359.10 PTS_EIIA_2 216596030742 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 216596030743 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596030744 active site 216596030745 phosphorylation site [posttranslational modification] 216596030746 intermolecular recognition site; other site 216596030747 dimerization interface [polypeptide binding]; other site 216596030748 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216596030749 DNA binding site [nucleotide binding] 216596030750 Pfam match to entry PF00486.12 Trans_reg_C 216596030751 Pfam match to entry PF00072.10 Response_reg 216596030752 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 216596030753 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 216596030754 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 216596030755 Ligand Binding Site [chemical binding]; other site 216596030756 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 216596030757 GAF domain; Region: GAF_3; pfam13492 216596030758 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216596030759 dimer interface [polypeptide binding]; other site 216596030760 phosphorylation site [posttranslational modification] 216596030761 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596030762 ATP binding site [chemical binding]; other site 216596030763 Mg2+ binding site [ion binding]; other site 216596030764 G-X-G motif; other site 216596030765 Pfam match to entry PF02518.9 HATPase_c 216596030766 Pfam match to entry PF00512.10 HisKA 216596030767 Pfam match to entry PF01590.11 GAF 216596030768 4 probable transmembrane helices predicted at aa 404-421, 428-445, 450-467 and 480-502 216596030769 Pfam match to entry PF00582.12 Usp 216596030770 Pfam match to entry PF02702.5 KdpD 216596030771 potassium-transporting ATPase subunit C; Provisional; Region: PRK13999 216596030772 Pfam match to entry PF02669.4 KdpC 216596030773 1 probable transmembrane helix predicted at aa 7-29 216596030774 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 216596030775 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 216596030776 Soluble P-type ATPase [General function prediction only]; Region: COG4087 216596030777 7 probable transmembrane helices predicted at aa 30-52, 62-84, 219-241,251-273, 591-613, 618-640 and 653-673 216596030778 Pfam match to entry PF00702.10 Hydrolase 216596030779 Pfam match to entry PF00122.7 E1-E2_ATPase 216596030780 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 216596030781 Pfam match to entry PF03814.3 KdpA 216596030782 12 probable transmembrane helices predicted at aa 5-27, 63-85, 134-156, 177-199,257-279, 286-308, 328-350, 357-376, 380-402, 419-441,486-508 and 529-551 216596030783 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 216596030784 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 216596030785 inhibitor binding site; inhibition site 216596030786 catalytic Zn binding site [ion binding]; other site 216596030787 structural Zn binding site [ion binding]; other site 216596030788 NADP binding site [chemical binding]; other site 216596030789 tetramer interface [polypeptide binding]; other site 216596030790 Pfam match to entry PF00107.11 ADH_zinc_N 216596030791 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 216596030792 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 216596030793 5 probable transmembrane helices predicted at aa 10-32, 39-61, 94-116, 123-145 and 160-179 216596030794 Pfam match to entry PF00597.8 DedA 216596030795 mercuric reductase; Validated; Region: PRK06370 216596030796 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 216596030797 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 216596030798 Pfam match to entry PF02852.7 Pyr_redox_dim 216596030799 Pfam match to entry PF00070.12 Pyr_redox 216596030800 Predicted membrane protein [Function unknown]; Region: COG3918 216596030801 Pfam match to entry PF06731.1 DUF1209 216596030802 4 probable transmembrane helices predicted at aa 2-24, 39-61, 96-118 and 133-152 216596030803 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 216596030804 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 216596030805 FAD binding site [chemical binding]; other site 216596030806 substrate binding pocket [chemical binding]; other site 216596030807 catalytic base [active] 216596030808 Pfam match to entry PF00441.11 Acyl-CoA_dh 216596030809 Pfam match to entry PF02770.6 Acyl-CoA_dh_M 216596030810 Pfam match to entry PF02771.6 Acyl-CoA_dh_N 216596030811 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 216596030812 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596030813 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596030814 LysR substrate binding domain; Region: LysR_substrate; pfam03466 216596030815 dimerization interface [polypeptide binding]; other site 216596030816 Pfam match to entry PF03466.5 LysR_substrate 216596030817 Pfam match to entry PF00126.10 HTH_1 216596030818 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 216596030819 SLBB domain; Region: SLBB; pfam10531 216596030820 Pfam match to entry PF02563.5 Poly_export 216596030821 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 216596030822 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 216596030823 Ligand binding site; other site 216596030824 Putative Catalytic site; other site 216596030825 DXD motif; other site 216596030826 Pfam match to entry PF00535.10 Glycos_transf_2 216596030827 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 216596030828 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 216596030829 Pfam match to entry PF00534.8 Glycos_transf_1 216596030830 11 probable transmembrane helices predicted at aa 59-81, 91-113, 120-142,196-218, 225-244, 286-308, 328-345, 393-415, 436-458,468-487 and 494-516 216596030831 Protein of unknown function (DUF1616); Region: DUF1616; pfam07760 216596030832 5 probable transmembrane helices predicted at aa 7-25, 35-54, 67-89, 93-112 and 132-154 216596030833 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 216596030834 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 216596030835 active site 216596030836 Pfam match to entry PF00535.10 Glycos_transf_2 216596030837 1 probable transmembrane helix predicted at aa 289-311 216596030838 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 216596030839 12 probable transmembrane helices predicted at aa 20-42, 57-79, 92-114, 134-156,165-187, 192-214, 234-256, 269-291, 303-325, 335-357,370-392 and 402-421 216596030840 Endo-beta-mannanase [Carbohydrate transport and metabolism]; Region: COG3934 216596030841 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 216596030842 Pfam match to entry PF00150.7 Cellulase 216596030843 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 216596030844 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 216596030845 putative ligand binding site [chemical binding]; other site 216596030846 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 216596030847 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 216596030848 Walker A/P-loop; other site 216596030849 ATP binding site [chemical binding]; other site 216596030850 Q-loop/lid; other site 216596030851 ABC transporter signature motif; other site 216596030852 Walker B; other site 216596030853 D-loop; other site 216596030854 H-loop/switch region; other site 216596030855 Pfam match to entry PF00005.11 ABC_tran 216596030856 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 216596030857 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 216596030858 Walker A/P-loop; other site 216596030859 ATP binding site [chemical binding]; other site 216596030860 Q-loop/lid; other site 216596030861 ABC transporter signature motif; other site 216596030862 Walker B; other site 216596030863 D-loop; other site 216596030864 H-loop/switch region; other site 216596030865 Pfam match to entry PF00005.11 ABC_tran 216596030866 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596030867 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 216596030868 TM-ABC transporter signature motif; other site 216596030869 8 probable transmembrane helices predicted at aa 15-37, 44-66, 70-92, 101-123,146-168, 189-211, 231-253 and 265-287 216596030870 Pfam match to entry PF02653.5 BPD_transp_2 216596030871 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 216596030872 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 216596030873 TM-ABC transporter signature motif; other site 216596030874 8 probable transmembrane helices predicted at aa 4-26, 33-55, 75-97, 102-124,149-171, 200-222, 237-259 and 271-293 216596030875 Pfam match to entry PF02653.5 BPD_transp_2 216596030876 choline dehydrogenase; Validated; Region: PRK02106 216596030877 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 216596030878 Pfam match to entry PF00732.8 GMC_oxred_N 216596030879 Pfam match to entry PF05199.2 GMC_oxred_C 216596030880 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 216596030881 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 216596030882 Pfam match to entry PF03446.3 NAD_binding_2 216596030883 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 216596030884 Novosphingobium aromaticivorans carbohydrate kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_NaCK_like; cd07772 216596030885 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 216596030886 N- and C-terminal domain interface [polypeptide binding]; other site 216596030887 putative active site [active] 216596030888 putative MgATP binding site [chemical binding]; other site 216596030889 putative catalytic site [active] 216596030890 metal binding site [ion binding]; metal-binding site 216596030891 putative carbohydrate binding site [chemical binding]; other site 216596030892 Pfam match to entry PF00370.9 FGGY_N 216596030893 Domain of unknown function (DUF718); Region: DUF718; pfam05336 216596030894 Pfam match to entry PF05336.1 DUF718 216596030895 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216596030896 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596030897 TM-ABC transporter signature motif; other site 216596030898 8 probable transmembrane helices predicted at aa 24-46, 66-88, 109-131,135-154, 174-196, 227-246, 267-289 and 304-326 216596030899 Pfam match to entry PF02653.5 BPD_transp_2 216596030900 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 216596030901 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 216596030902 TM-ABC transporter signature motif; other site 216596030903 8 probable transmembrane helices predicted at aa 12-31, 46-68, 89-111, 126-145,158-180, 212-234, 247-269 and 284-306 216596030904 Pfam match to entry PF02653.5 BPD_transp_2 216596030905 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 216596030906 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 216596030907 Walker A/P-loop; other site 216596030908 ATP binding site [chemical binding]; other site 216596030909 Q-loop/lid; other site 216596030910 ABC transporter signature motif; other site 216596030911 Walker B; other site 216596030912 D-loop; other site 216596030913 H-loop/switch region; other site 216596030914 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 216596030915 Pfam match to entry PF00005.11 ABC_tran 216596030916 Pfam match to entry PF00005.11 ABC_tran 216596030917 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 216596030918 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 216596030919 ligand binding site [chemical binding]; other site 216596030920 Pfam match to entry PF00532.8 Peripla_BP_1 216596030921 1 probable transmembrane helix predicted at aa 12-34 216596030922 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 216596030923 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 216596030924 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 216596030925 Pfam match to entry PF00455.10 DeoR 216596030926 Predicted helix-turn-helix motif with score 978.000, SD 2.52 at aa 36-57, sequence VTVQDISELTEASEATIRRDIA 216596030927 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase; Region: RhaD_aldol-ADH; TIGR02632 216596030928 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 216596030929 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 216596030930 putative NAD(P) binding site [chemical binding]; other site 216596030931 active site 216596030932 Pfam match to entry PF00106.11 adh_short 216596030933 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952 216596030934 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 216596030935 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 216596030936 Uncharacterized conserved protein [Function unknown]; Region: COG2128 216596030937 Pfam match to entry PF02627.6 CMD 216596030938 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 216596030939 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 216596030940 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 216596030941 DNA binding residues [nucleotide binding] 216596030942 Pfam match to entry PF04542.2 Sigma70_r2 216596030943 Predicted amidohydrolase [General function prediction only]; Region: COG3964 216596030944 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 216596030945 active site 216596030946 Pfam match to entry PF01979.7 Amidohydro_1 216596030947 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 216596030948 Transcriptional regulator [Transcription]; Region: IclR; COG1414 216596030949 Bacterial transcriptional regulator; Region: IclR; pfam01614 216596030950 Pfam match to entry PF01614.6 IclR 216596030951 short chain dehydrogenase; Provisional; Region: PRK06701 216596030952 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 216596030953 NAD binding site [chemical binding]; other site 216596030954 metal binding site [ion binding]; metal-binding site 216596030955 active site 216596030956 Pfam match to entry PF00106.11 adh_short 216596030957 Poxvirus protein I1; Region: Pox_I1; cl17575 216596030958 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 216596030959 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 216596030960 Pfam match to entry PF00440.8 TetR_N 216596030961 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 216596030962 1 probable transmembrane helix predicted at aa 46-63 216596030963 hypothetical protein; Provisional; Region: PRK06102 216596030964 Amidase; Region: Amidase; cl11426 216596030965 Pfam match to entry PF01425.8 Amidase 216596030966 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 216596030967 Sulfatase; Region: Sulfatase; cl17466 216596030968 choline-sulfatase; Region: chol_sulfatase; TIGR03417 216596030969 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 216596030970 Pfam match to entry PF00884.10 Sulfatase 216596030971 Predicted helix-turn-helix motif with score 1013.000, SD 2.64 at aa 234-255, sequence LMKACDHDAFNISDEQIRRARR 216596030972 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 216596030973 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596030974 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216596030975 dimerization interface [polypeptide binding]; other site 216596030976 Pfam match to entry PF00126.10 HTH_1 216596030977 Predicted helix-turn-helix motif with score 1689.000, SD 4.94 at aa 22-43, sequence GSFSAAAAGLGLTQPAVSYQIR 216596030978 Pfam match to entry PF03466.5 LysR_substrate 216596030979 2 probable transmembrane helices predicted at aa 13-32 and 52-74 216596030980 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 216596030981 Pfam match to entry PF03328.3 HpcH_HpaI 216596030982 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 216596030983 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596030984 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 216596030985 Walker A/P-loop; other site 216596030986 ATP binding site [chemical binding]; other site 216596030987 Q-loop/lid; other site 216596030988 ABC transporter signature motif; other site 216596030989 Walker B; other site 216596030990 D-loop; other site 216596030991 H-loop/switch region; other site 216596030992 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 216596030993 Pfam match to entry PF00005.11 ABC_tran 216596030994 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 216596030995 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596030996 Walker A/P-loop; other site 216596030997 ATP binding site [chemical binding]; other site 216596030998 Q-loop/lid; other site 216596030999 ABC transporter signature motif; other site 216596031000 Walker B; other site 216596031001 D-loop; other site 216596031002 H-loop/switch region; other site 216596031003 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216596031004 Pfam match to entry PF00005.11 ABC_tran 216596031005 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 216596031006 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596031007 dimer interface [polypeptide binding]; other site 216596031008 conserved gate region; other site 216596031009 putative PBP binding loops; other site 216596031010 ABC-ATPase subunit interface; other site 216596031011 Pfam match to entry PF00528.10 BPD_transp_1 216596031012 6 probable transmembrane helices predicted at aa 13-30, 73-95, 107-129,134-151, 183-205 and 242-264 216596031013 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 216596031014 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596031015 dimer interface [polypeptide binding]; other site 216596031016 conserved gate region; other site 216596031017 putative PBP binding loops; other site 216596031018 ABC-ATPase subunit interface; other site 216596031019 Pfam match to entry PF00528.10 BPD_transp_1 216596031020 6 probable transmembrane helices predicted at aa 7-29, 99-121, 134-165,185-207, 245-267 and 296-318 216596031021 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 216596031022 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 216596031023 substrate binding site [chemical binding]; other site 216596031024 Pfam match to entry PF00496.9 SBP_bac_5 216596031025 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 216596031026 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 216596031027 Pfam match to entry PF00933.10 Glyco_hydro_3 216596031028 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 216596031029 Coenzyme A binding pocket [chemical binding]; other site 216596031030 Pfam match to entry PF00583.9 Acetyltransf_1 216596031031 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 216596031032 dimer interface [polypeptide binding]; other site 216596031033 substrate binding site [chemical binding]; other site 216596031034 ATP binding site [chemical binding]; other site 216596031035 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 216596031036 thiamine phosphate binding site [chemical binding]; other site 216596031037 active site 216596031038 pyrophosphate binding site [ion binding]; other site 216596031039 Pfam match to entry PF02581.5 TMP-TENI 216596031040 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 216596031041 substrate binding site [chemical binding]; other site 216596031042 multimerization interface [polypeptide binding]; other site 216596031043 ATP binding site [chemical binding]; other site 216596031044 Pfam match to entry PF02110.5 HK 216596031045 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 216596031046 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 216596031047 active site 216596031048 catalytic triad [active] 216596031049 Pfam match to entry PF00082.10 Peptidase_S8 216596031050 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 216596031051 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596031052 Walker A/P-loop; other site 216596031053 ATP binding site [chemical binding]; other site 216596031054 Q-loop/lid; other site 216596031055 ABC transporter signature motif; other site 216596031056 Walker B; other site 216596031057 D-loop; other site 216596031058 H-loop/switch region; other site 216596031059 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216596031060 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596031061 Walker A/P-loop; other site 216596031062 ATP binding site [chemical binding]; other site 216596031063 Q-loop/lid; other site 216596031064 ABC transporter signature motif; other site 216596031065 Walker B; other site 216596031066 D-loop; other site 216596031067 H-loop/switch region; other site 216596031068 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216596031069 Pfam match to entry PF00005.11 ABC_tran 216596031070 Pfam match to entry PF00005.11 ABC_tran 216596031071 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 216596031072 Pfam match to entry PF03069.4 FmdA_AmdA 216596031073 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 216596031074 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 216596031075 Pfam match to entry PF00496.9 SBP_bac_5 216596031076 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 216596031077 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596031078 dimer interface [polypeptide binding]; other site 216596031079 conserved gate region; other site 216596031080 putative PBP binding loops; other site 216596031081 ABC-ATPase subunit interface; other site 216596031082 Pfam match to entry PF00528.10 BPD_transp_1 216596031083 6 probable transmembrane helices predicted at aa 13-32, 100-122, 135-157,167-189, 227-249 and 269-291 216596031084 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 216596031085 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 216596031086 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596031087 dimer interface [polypeptide binding]; other site 216596031088 conserved gate region; other site 216596031089 putative PBP binding loops; other site 216596031090 ABC-ATPase subunit interface; other site 216596031091 Pfam match to entry PF00528.10 BPD_transp_1 216596031092 6 probable transmembrane helices predicted at aa 13-35, 84-106, 113-135,140-162, 191-213 and 244-266 216596031093 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 216596031094 ANTAR domain; Region: ANTAR; pfam03861 216596031095 Pfam match to entry PF03861.3 ANTAR 216596031096 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 216596031097 Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357 216596031098 ligand binding site [chemical binding]; other site 216596031099 regulator interaction site; other site 216596031100 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 216596031101 Pfam match to entry PF07081.1 DUF1349 216596031102 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 216596031103 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 216596031104 Pfam match to entry PF00496.9 SBP_bac_5 216596031105 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 216596031106 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596031107 dimer interface [polypeptide binding]; other site 216596031108 conserved gate region; other site 216596031109 putative PBP binding loops; other site 216596031110 ABC-ATPase subunit interface; other site 216596031111 6 probable transmembrane helices predicted at aa 9-31, 100-122, 135-157,177-199, 234-256 and 285-307 216596031112 Pfam match to entry PF00528.10 BPD_transp_1 216596031113 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 216596031114 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596031115 dimer interface [polypeptide binding]; other site 216596031116 conserved gate region; other site 216596031117 putative PBP binding loops; other site 216596031118 ABC-ATPase subunit interface; other site 216596031119 5 probable transmembrane helices predicted at aa 25-47, 92-114, 135-157,211-233 and 254-273 216596031120 Pfam match to entry PF00528.10 BPD_transp_1 216596031121 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 216596031122 homotrimer interaction site [polypeptide binding]; other site 216596031123 putative active site [active] 216596031124 Pfam match to entry PF01042.8 Ribonuc_L-PSP 216596031125 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 216596031126 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 216596031127 catalytic residue [active] 216596031128 Pfam match to entry PF03841.3 SelA 216596031129 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 216596031130 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596031131 Walker A/P-loop; other site 216596031132 ATP binding site [chemical binding]; other site 216596031133 Q-loop/lid; other site 216596031134 ABC transporter signature motif; other site 216596031135 Walker B; other site 216596031136 D-loop; other site 216596031137 H-loop/switch region; other site 216596031138 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216596031139 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596031140 Walker A/P-loop; other site 216596031141 ATP binding site [chemical binding]; other site 216596031142 Q-loop/lid; other site 216596031143 ABC transporter signature motif; other site 216596031144 Walker B; other site 216596031145 D-loop; other site 216596031146 H-loop/switch region; other site 216596031147 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 216596031148 Pfam match to entry PF00005.11 ABC_tran 216596031149 Pfam match to entry PF00005.11 ABC_tran 216596031150 polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849 216596031151 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 216596031152 Pfam match to entry PF06850.1 PHB_depo_C 216596031153 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 216596031154 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 216596031155 putative C-terminal domain interface [polypeptide binding]; other site 216596031156 putative GSH binding site (G-site) [chemical binding]; other site 216596031157 putative dimer interface [polypeptide binding]; other site 216596031158 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 216596031159 putative N-terminal domain interface [polypeptide binding]; other site 216596031160 putative dimer interface [polypeptide binding]; other site 216596031161 putative substrate binding pocket (H-site) [chemical binding]; other site 216596031162 Pfam match to entry PF02798.6 GST_N 216596031163 hypothetical protein; Provisional; Region: PRK11171 216596031164 Cupin domain; Region: Cupin_2; pfam07883 216596031165 Cupin domain; Region: Cupin_2; pfam07883 216596031166 Pfam match to entry PF06038.1 DUF923 216596031167 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 216596031168 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 216596031169 Pfam match to entry PF00583.9 Acetyltransf_1 216596031170 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 216596031171 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216596031172 non-specific DNA binding site [nucleotide binding]; other site 216596031173 salt bridge; other site 216596031174 sequence-specific DNA binding site [nucleotide binding]; other site 216596031175 Pfam match to entry PF01381.9 HTH_3 216596031176 Predicted helix-turn-helix motif with score 1662.000, SD 4.85 at aa 42-63, sequence WKQADVAEALGIPQPRVSELMR 216596031177 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 216596031178 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 216596031179 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 216596031180 Pfam match to entry PF06724.1 DUF1206 216596031181 6 probable transmembrane helices predicted at aa 38-60, 75-97, 118-140,160-182, 208-230 and 250-272 216596031182 Pfam match to entry PF06724.1 DUF1206 216596031183 Pfam match to entry PF06724.1 DUF1206 216596031184 Putative integral membrane protein (DUF2391); Region: DUF2391; pfam09622 216596031185 8 probable transmembrane helices predicted at aa 41-63, 70-89, 104-126,133-155, 180-202, 215-237, 252-274 and 281-303 216596031186 TIGR02588 family protein; Region: TIGR02588 216596031187 1 probable transmembrane helix predicted at aa 15-37 216596031188 Pirin-related protein [General function prediction only]; Region: COG1741 216596031189 Pirin; Region: Pirin; pfam02678 216596031190 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 216596031191 Pfam match to entry PF05726.1 Pirin_C 216596031192 Pfam match to entry PF02678.4 Pirin 216596031193 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 216596031194 MOSC domain; Region: MOSC; pfam03473 216596031195 3-alpha domain; Region: 3-alpha; pfam03475 216596031196 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 216596031197 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 216596031198 FAD binding pocket [chemical binding]; other site 216596031199 FAD binding motif [chemical binding]; other site 216596031200 phosphate binding motif [ion binding]; other site 216596031201 beta-alpha-beta structure motif; other site 216596031202 NAD binding pocket [chemical binding]; other site 216596031203 Heme binding pocket [chemical binding]; other site 216596031204 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 216596031205 catalytic loop [active] 216596031206 iron binding site [ion binding]; other site 216596031207 Pfam match to entry PF00111.12 Fer2 216596031208 Pfam match to entry PF00175.8 NAD_binding_1 216596031209 Pfam match to entry PF00970.9 FAD_binding_6 216596031210 Pfam match to entry PF03475.3 3-alpha 216596031211 Pfam match to entry PF03473.5 MOSC 216596031212 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 216596031213 active site 216596031214 Pfam match to entry PF03167.6 UDG 216596031215 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 216596031216 5 probable transmembrane helices predicted at aa 7-29, 44-61, 74-96, 106-128 and 140-159 216596031217 Pfam match to entry PF04657.2 DUF606 216596031218 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 216596031219 5 probable transmembrane helices predicted at aa 4-21, 34-56, 66-85, 90-112 and 117-136 216596031220 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 216596031221 amidohydrolase; Region: amidohydrolases; TIGR01891 216596031222 putative metal binding site [ion binding]; other site 216596031223 Pfam match to entry PF01546.13 Peptidase_M20 216596031224 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 216596031225 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 216596031226 Pfam match to entry PF00496.9 SBP_bac_5 216596031227 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 216596031228 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 216596031229 Pfam match to entry PF00144.10 Beta-lactamase 216596031230 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 216596031231 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596031232 Walker A/P-loop; other site 216596031233 ATP binding site [chemical binding]; other site 216596031234 Q-loop/lid; other site 216596031235 ABC transporter signature motif; other site 216596031236 Walker B; other site 216596031237 D-loop; other site 216596031238 H-loop/switch region; other site 216596031239 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216596031240 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596031241 Walker A/P-loop; other site 216596031242 ATP binding site [chemical binding]; other site 216596031243 Q-loop/lid; other site 216596031244 ABC transporter signature motif; other site 216596031245 Walker B; other site 216596031246 D-loop; other site 216596031247 H-loop/switch region; other site 216596031248 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216596031249 Pfam match to entry PF00005.11 ABC_tran 216596031250 Pfam match to entry PF00005.11 ABC_tran 216596031251 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 216596031252 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596031253 dimer interface [polypeptide binding]; other site 216596031254 conserved gate region; other site 216596031255 putative PBP binding loops; other site 216596031256 ABC-ATPase subunit interface; other site 216596031257 Pfam match to entry PF00528.10 BPD_transp_1 216596031258 6 probable transmembrane helices predicted at aa 7-29, 72-94, 107-129, 133-155,181-203 and 235-257 216596031259 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 216596031260 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596031261 dimer interface [polypeptide binding]; other site 216596031262 conserved gate region; other site 216596031263 putative PBP binding loops; other site 216596031264 ABC-ATPase subunit interface; other site 216596031265 Pfam match to entry PF00528.10 BPD_transp_1 216596031266 6 probable transmembrane helices predicted at aa 19-41, 115-137, 144-166,181-203, 256-278 and 293-314 216596031267 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596031268 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596031269 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 216596031270 putative dimerization interface [polypeptide binding]; other site 216596031271 Pfam match to entry PF03466.5 LysR_substrate 216596031272 Pfam match to entry PF00126.10 HTH_1 216596031273 Predicted helix-turn-helix motif with score 1690.000, SD 4.94 at aa 16-37, sequence GSTIATAKTMGLSQSGVSRLLQ 216596031274 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596031275 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596031276 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 216596031277 dimerization interface [polypeptide binding]; other site 216596031278 Pfam match to entry PF03466.5 LysR_substrate 216596031279 Pfam match to entry PF00126.10 HTH_1 216596031280 Predicted helix-turn-helix motif with score 1290.000, SD 3.58 at aa 47-68, sequence GSTIAASVELGISQSNASRLLQ 216596031281 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 216596031282 Pfam match to entry PF03972.3 MmgE_PrpD 216596031283 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 216596031284 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 216596031285 Pfam match to entry PF01738.6 DLH 216596031286 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 216596031287 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 216596031288 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 216596031289 Pfam match to entry PF01408.8 GFO_IDH_MocA 216596031290 Pfam match to entry PF02894.4 GFO_IDH_MocA_C 216596031291 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 216596031292 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596031293 dimer interface [polypeptide binding]; other site 216596031294 conserved gate region; other site 216596031295 putative PBP binding loops; other site 216596031296 ABC-ATPase subunit interface; other site 216596031297 6 probable transmembrane helices predicted at aa 7-29, 66-88, 101-123, 155-177,206-228 and 263-285 216596031298 Pfam match to entry PF00528.10 BPD_transp_1 216596031299 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 216596031300 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596031301 dimer interface [polypeptide binding]; other site 216596031302 conserved gate region; other site 216596031303 ABC-ATPase subunit interface; other site 216596031304 6 probable transmembrane helices predicted at aa 12-34, 82-104, 111-133,143-165, 194-216 and 248-270 216596031305 Pfam match to entry PF00528.10 BPD_transp_1 216596031306 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 216596031307 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 216596031308 Pfam match to entry PF01547.11 SBP_bac_1 216596031309 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 216596031310 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 216596031311 Walker A/P-loop; other site 216596031312 ATP binding site [chemical binding]; other site 216596031313 Q-loop/lid; other site 216596031314 ABC transporter signature motif; other site 216596031315 Walker B; other site 216596031316 D-loop; other site 216596031317 H-loop/switch region; other site 216596031318 TOBE domain; Region: TOBE_2; pfam08402 216596031319 Pfam match to entry PF00005.11 ABC_tran 216596031320 8 probable transmembrane helices predicted at aa 53-75, 82-99, 109-128,141-163, 232-254, 267-289, 309-328 and 443-465 216596031321 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 216596031322 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 216596031323 Pfam match to entry PF05199.2 GMC_oxred_C 216596031324 Pfam match to entry PF00732.8 GMC_oxred_N 216596031325 1 probable transmembrane helix predicted at aa 5-27 216596031326 4 probable transmembrane helices predicted at aa 13-35, 50-72, 79-101 and 106-128 216596031327 1 probable transmembrane helix predicted at aa 36-58 216596031328 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 216596031329 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 216596031330 active site 216596031331 FMN binding site [chemical binding]; other site 216596031332 substrate binding site [chemical binding]; other site 216596031333 putative catalytic residue [active] 216596031334 Pfam match to entry PF00724.7 Oxidored_FMN 216596031335 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 216596031336 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820 216596031337 dimer interface [polypeptide binding]; other site 216596031338 active site 216596031339 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 216596031340 substrate binding site [chemical binding]; other site 216596031341 catalytic residue [active] 216596031342 Pfam match to entry PF01168.8 Ala_racemase_N 216596031343 Uncharacterized conserved protein [Function unknown]; Region: COG5476 216596031344 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 216596031345 MlrC C-terminus; Region: MlrC_C; pfam07171 216596031346 Pfam match to entry PF07171.1 MlrC_C 216596031347 Pfam match to entry PF07364.1 DUF1485 216596031348 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 216596031349 homotrimer interaction site [polypeptide binding]; other site 216596031350 putative active site [active] 216596031351 Pfam match to entry PF01042.8 Ribonuc_L-PSP 216596031352 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 216596031353 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 216596031354 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 216596031355 putative active site [active] 216596031356 Pfam match to entry PF01418.7 HTH_6 216596031357 Predicted helix-turn-helix motif with score 1623.000, SD 4.71 at aa 35-56, sequence ASIIELAERAEVSPPTVTRFCR 216596031358 Pfam match to entry PF01380.9 SIS 216596031359 short chain dehydrogenase; Provisional; Region: PRK07074 216596031360 classical (c) SDRs; Region: SDR_c; cd05233 216596031361 NAD(P) binding site [chemical binding]; other site 216596031362 active site 216596031363 Pfam match to entry PF00106.11 adh_short 216596031364 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596031365 12 probable transmembrane helices predicted at aa 12-34, 49-71, 78-97, 102-124,145-167, 171-193, 225-247, 257-279, 286-305, 309-331,344-366 and 371-393 216596031366 Pfam match to entry PF07690.1 MFS_1 216596031367 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 216596031368 non-specific DNA interactions [nucleotide binding]; other site 216596031369 DNA binding site [nucleotide binding] 216596031370 sequence specific DNA binding site [nucleotide binding]; other site 216596031371 putative cAMP binding site [chemical binding]; other site 216596031372 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 216596031373 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 216596031374 nucleotide binding site [chemical binding]; other site 216596031375 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 216596031376 Predicted helix-turn-helix motif with score 1448.000, SD 4.12 at aa 30-51, sequence LSRAAIARMTALTAQTVSNIVE 216596031377 Pfam match to entry PF00480.8 ROK 216596031378 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 216596031379 EamA-like transporter family; Region: EamA; pfam00892 216596031380 Pfam match to entry PF00892.8 DUF6 216596031381 10 probable transmembrane helices predicted at aa 98-120, 124-146, 158-180,185-207, 214-235, 245-262, 275-297, 307-329, 336-355 and 360-379 216596031382 Pfam match to entry PF00892.8 DUF6 216596031383 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 216596031384 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216596031385 Pfam match to entry PF00165.8 HTH_AraC 216596031386 Pfam match to entry PF00165.8 HTH_AraC 216596031387 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 216596031388 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 216596031389 putative NAD(P) binding site [chemical binding]; other site 216596031390 Pfam match to entry PF00107.11 ADH_zinc_N 216596031391 short chain dehydrogenase; Provisional; Region: PRK06179 216596031392 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 216596031393 NADP binding site [chemical binding]; other site 216596031394 active site 216596031395 steroid binding site; other site 216596031396 Pfam match to entry PF00106.11 adh_short 216596031397 Predicted transcriptional regulators [Transcription]; Region: COG1733 216596031398 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 216596031399 Pfam match to entry PF01638.6 DUF24 216596031400 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 216596031401 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 216596031402 active site 216596031403 Pfam match to entry PF00728.9 Glyco_hydro_20 216596031404 Pfam match to entry PF02838.4 Glyco_hydro_20b 216596031405 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596031406 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 216596031407 Walker A/P-loop; other site 216596031408 ATP binding site [chemical binding]; other site 216596031409 Q-loop/lid; other site 216596031410 ABC transporter signature motif; other site 216596031411 Walker B; other site 216596031412 D-loop; other site 216596031413 H-loop/switch region; other site 216596031414 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 216596031415 Pfam match to entry PF00005.11 ABC_tran 216596031416 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 216596031417 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 216596031418 Walker A/P-loop; other site 216596031419 ATP binding site [chemical binding]; other site 216596031420 Q-loop/lid; other site 216596031421 ABC transporter signature motif; other site 216596031422 Walker B; other site 216596031423 D-loop; other site 216596031424 H-loop/switch region; other site 216596031425 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 216596031426 Pfam match to entry PF00005.11 ABC_tran 216596031427 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 216596031428 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 216596031429 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596031430 dimer interface [polypeptide binding]; other site 216596031431 conserved gate region; other site 216596031432 putative PBP binding loops; other site 216596031433 ABC-ATPase subunit interface; other site 216596031434 Pfam match to entry PF00528.10 BPD_transp_1 216596031435 5 probable transmembrane helices predicted at aa 13-35, 81-103, 124-146,187-209 and 241-263 216596031436 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 216596031437 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596031438 dimer interface [polypeptide binding]; other site 216596031439 conserved gate region; other site 216596031440 putative PBP binding loops; other site 216596031441 ABC-ATPase subunit interface; other site 216596031442 Pfam match to entry PF00528.10 BPD_transp_1 216596031443 6 probable transmembrane helices predicted at aa 7-29, 104-126, 139-161,181-203, 250-272 and 296-318 216596031444 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 216596031445 substrate binding site [chemical binding]; other site 216596031446 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 216596031447 Pfam match to entry PF00496.9 SBP_bac_5 216596031448 flagellin; Reviewed; Region: PRK12687 216596031449 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 216596031450 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 216596031451 Pfam match to entry PF00669.8 Flagellin_N 216596031452 Pfam match to entry PF00700.8 Flagellin_C 216596031453 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 216596031454 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596031455 putative substrate translocation pore; other site 216596031456 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596031457 14 probable transmembrane helices predicted at aa 16-38, 58-80, 85-107, 117-136,143-165, 169-191, 204-222, 232-254, 274-296, 311-333,340-358, 373-392, 404-426 and 485-507 216596031458 Pfam match to entry PF07690.1 MFS_1 216596031459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596031460 Major Facilitator Superfamily; Region: MFS_1; pfam07690 216596031461 putative substrate translocation pore; other site 216596031462 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 216596031463 Pfam match to entry PF00083.10 Sugar_tr 216596031464 12 probable transmembrane helices predicted at aa 7-26, 36-58, 65-87, 91-113,125-147, 157-176, 235-254, 269-291, 298-317, 322-344,357-379 and 383-405 216596031465 Pfam match to entry PF07690.1 MFS_1 216596031466 PRC-barrel domain; Region: PRC; pfam05239 216596031467 Pfam match to entry PF05239.2 PRC 216596031468 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 216596031469 active site 216596031470 catalytic site [active] 216596031471 substrate binding site [chemical binding]; other site 216596031472 Pfam match to entry PF00929.11 Exonuc_X-T 216596031473 1 probable transmembrane helix predicted at aa 10-32 216596031474 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 216596031475 Transcriptional regulators [Transcription]; Region: FadR; COG2186 216596031476 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 216596031477 DNA-binding site [nucleotide binding]; DNA binding site 216596031478 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 216596031479 Pfam match to entry PF00392.9 GntR 216596031480 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 216596031481 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 216596031482 NADP binding site [chemical binding]; other site 216596031483 homodimer interface [polypeptide binding]; other site 216596031484 active site 216596031485 Pfam match to entry PF00106.11 adh_short 216596031486 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 216596031487 Pfam match to entry PF04962.2 KduI 216596031488 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 216596031489 Pfam match to entry PF06568.1 DUF1127 216596031490 DNA polymerase III subunit epsilon; Validated; Region: PRK09182 216596031491 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 216596031492 active site 216596031493 catalytic site [active] 216596031494 substrate binding site [chemical binding]; other site 216596031495 Pfam match to entry PF00929.11 Exonuc_X-T 216596031496 Src Homology 3 domain superfamily; Region: SH3; cl17036 216596031497 peptide ligand binding site [polypeptide binding]; other site 216596031498 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 216596031499 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 216596031500 dimer interface [polypeptide binding]; other site 216596031501 phosphorylation site [posttranslational modification] 216596031502 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 216596031503 ATP binding site [chemical binding]; other site 216596031504 Mg2+ binding site [ion binding]; other site 216596031505 G-X-G motif; other site 216596031506 Pfam match to entry PF02518.9 HATPase_c 216596031507 Pfam match to entry PF00512.10 HisKA 216596031508 Pfam match to entry PF00672.10 HAMP 216596031509 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 216596031510 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 216596031511 active site 216596031512 phosphorylation site [posttranslational modification] 216596031513 intermolecular recognition site; other site 216596031514 dimerization interface [polypeptide binding]; other site 216596031515 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 216596031516 DNA binding site [nucleotide binding] 216596031517 Pfam match to entry PF00486.12 Trans_reg_C 216596031518 Pfam match to entry PF00072.10 Response_reg 216596031519 haloalkane dehalogenase; Provisional; Region: PRK03592 216596031520 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 216596031521 catalytic site [active] 216596031522 Pfam match to entry PF00561.8 Abhydrolase_1 216596031523 MarR family; Region: MarR_2; cl17246 216596031524 Transcriptional regulators [Transcription]; Region: MarR; COG1846 216596031525 Pfam match to entry PF01047.8 MarR 216596031526 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 216596031527 Pfam match to entry PF01593.9 Amino_oxidase 216596031528 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 216596031529 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 216596031530 active site 216596031531 catalytic tetrad [active] 216596031532 Pfam match to entry PF00248.9 Aldo_ket_red 216596031533 Amino acid permease; Region: AA_permease_2; pfam13520 216596031534 12 probable transmembrane helices predicted at aa 25-47, 52-74, 104-126,203-225, 242-264, 284-306, 327-349, 373-395, 436-458,490-509, 516-538 and 568-590 216596031535 Pfam match to entry PF00324.10 AA_permease 216596031536 Uncharacterized conserved protein [Function unknown]; Region: COG3665 216596031537 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 216596031538 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 216596031539 Pfam match to entry PF01571.8 GCV_T 216596031540 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 216596031541 DNA-binding site [nucleotide binding]; DNA binding site 216596031542 RNA-binding motif; other site 216596031543 Pfam match to entry PF00313.8 CSD 216596031544 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 216596031545 Pfam match to entry PF03776.3 MinE 216596031546 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 216596031547 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 216596031548 Switch I; other site 216596031549 Switch II; other site 216596031550 Pfam match to entry PF01656.8 CbiA 216596031551 septum formation inhibitor; Reviewed; Region: minC; PRK05177 216596031552 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 216596031553 Pfam match to entry PF03775.5 MinC_C 216596031554 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 216596031555 PAS fold; Region: PAS_3; pfam08447 216596031556 putative active site [active] 216596031557 heme pocket [chemical binding]; other site 216596031558 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 216596031559 putative CheW interface [polypeptide binding]; other site 216596031560 Pfam match to entry PF00015.9 MCPsignal 216596031561 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 216596031562 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 216596031563 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 216596031564 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 216596031565 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 216596031566 FMN-binding pocket [chemical binding]; other site 216596031567 flavin binding motif; other site 216596031568 phosphate binding motif [ion binding]; other site 216596031569 beta-alpha-beta structure motif; other site 216596031570 NAD binding pocket [chemical binding]; other site 216596031571 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 216596031572 catalytic loop [active] 216596031573 iron binding site [ion binding]; other site 216596031574 Pfam match to entry PF00111.12 Fer2 216596031575 Pfam match to entry PF00175.8 NAD_binding_1 216596031576 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 216596031577 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 216596031578 Pfam match to entry PF01571.8 GCV_T 216596031579 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 216596031580 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 216596031581 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 216596031582 putative active site [active] 216596031583 putative substrate binding site [chemical binding]; other site 216596031584 putative cosubstrate binding site; other site 216596031585 catalytic site [active] 216596031586 Pfam match to entry PF00551.8 Formyl_trans_N 216596031587 Pfam match to entry PF01842.8 ACT 216596031588 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 216596031589 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 216596031590 Pfam match to entry PF00120.9 Gln-synt_C 216596031591 Pfam match to entry PF03951.4 Gln-synt_N 216596031592 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 216596031593 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 216596031594 active site 216596031595 FMN binding site [chemical binding]; other site 216596031596 substrate binding site [chemical binding]; other site 216596031597 3Fe-4S cluster binding site [ion binding]; other site 216596031598 Pfam match to entry PF01645.6 Glu_synthase 216596031599 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 216596031600 domain_subunit interface; other site 216596031601 Pfam match to entry PF01493.7 GXGXG 216596031602 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 216596031603 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 216596031604 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 216596031605 putative active site [active] 216596031606 Pfam match to entry PF00310.9 GATase_2 216596031607 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216596031608 non-specific DNA binding site [nucleotide binding]; other site 216596031609 salt bridge; other site 216596031610 sequence-specific DNA binding site [nucleotide binding]; other site 216596031611 Cupin domain; Region: Cupin_2; pfam07883 216596031612 Predicted helix-turn-helix motif with score 990.000, SD 2.56 at aa 98-119, sequence TTLQSLSRALGVPLTAFFRRFE 216596031613 Pfam match to entry PF01381.9 HTH_3 216596031614 Predicted helix-turn-helix motif with score 1402.000, SD 3.96 at aa 98-90, sequence NGNISPSLT 216596031615 Predicted helix-turn-helix motif with score 1402.000, SD 3.96 at aa 69-90, sequence ITVTDLAAATGISLGMLSKIEN 216596031616 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 216596031617 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 216596031618 conserved cys residue [active] 216596031619 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 216596031620 Pfam match to entry PF00165.8 HTH_AraC 216596031621 Pfam match to entry PF00165.8 HTH_AraC 216596031622 Predicted helix-turn-helix motif with score 1294.000, SD 3.59 at aa 235-256, sequence LERAAMARIAGVTTRHLDRLFA 216596031623 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 216596031624 hydroxyglutarate oxidase; Provisional; Region: PRK11728 216596031625 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 216596031626 Pfam match to entry PF04267.2 SoxD 216596031627 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 216596031628 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 216596031629 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 216596031630 Pfam match to entry PF01571.8 GCV_T 216596031631 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 216596031632 Pfam match to entry PF04268.2 SoxG 216596031633 Type II/IV secretion system protein; Region: T2SE; pfam00437 216596031634 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 216596031635 ATP binding site [chemical binding]; other site 216596031636 Walker A motif; other site 216596031637 hexamer interface [polypeptide binding]; other site 216596031638 Walker B motif; other site 216596031639 Pfam match to entry PF00437.9 GSPII_E 216596031640 1 probable transmembrane helix predicted at aa 41-63 216596031641 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 216596031642 6 probable transmembrane helices predicted at aa 7-27, 37-59, 61-83, 98-120,127-149 and 164-186 216596031643 Pfam match to entry PF01478.6 Peptidase_A24 216596031644 2 probable transmembrane helices predicted at aa 50-72 and 93-112 216596031645 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 216596031646 2 probable transmembrane helices predicted at aa 15-37 and 138-160 216596031647 1 probable transmembrane helix predicted at aa 31-53 216596031648 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 216596031649 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 216596031650 1 probable transmembrane helix predicted at aa 5-22 216596031651 Pfam match to entry PF06981.1 CpaB 216596031652 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 216596031653 phosphopeptide binding site; other site 216596031654 Type II/IV secretion system protein; Region: T2SE; pfam00437 216596031655 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 216596031656 ATP binding site [chemical binding]; other site 216596031657 Walker A motif; other site 216596031658 hexamer interface [polypeptide binding]; other site 216596031659 Walker B motif; other site 216596031660 Pfam match to entry PF00437.9 GSPII_E 216596031661 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 216596031662 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 216596031663 4 probable transmembrane helices predicted at aa 34-56, 93-127, 261-283 and 287-309 216596031664 Pfam match to entry PF00482.9 GSPII_F 216596031665 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 216596031666 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 216596031667 4 probable transmembrane helices predicted at aa 5-27, 96-118, 122-144 and 272-294 216596031668 Pfam match to entry PF00482.9 GSPII_F 216596031669 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 216596031670 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 216596031671 phosphopeptide binding site; other site 216596031672 Pfam match to entry PF00498.11 FHA 216596031673 1 probable transmembrane helix predicted at aa 134-156 216596031674 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 216596031675 cyclase homology domain; Region: CHD; cd07302 216596031676 nucleotidyl binding site; other site 216596031677 dimer interface [polypeptide binding]; other site 216596031678 metal binding site [ion binding]; metal-binding site 216596031679 Predicted integral membrane protein [Function unknown]; Region: COG5616 216596031680 TPR repeat; Region: TPR_11; pfam13414 216596031681 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216596031682 TPR motif; other site 216596031683 binding surface 216596031684 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216596031685 TPR motif; other site 216596031686 binding surface 216596031687 1 probable transmembrane helix predicted at aa 174-196 216596031688 Pfam match to entry PF00211.9 Guanylate_cyc 216596031689 LysR family transcriptional regulator; Provisional; Region: PRK14997 216596031690 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596031691 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 216596031692 putative effector binding pocket; other site 216596031693 putative dimerization interface [polypeptide binding]; other site 216596031694 Pfam match to entry PF03466.5 LysR_substrate 216596031695 Pfam match to entry PF00126.10 HTH_1 216596031696 Predicted helix-turn-helix motif with score 1281.000, SD 3.55 at aa 17-38, sequence GSFAAAAEIAQVSPAMVAKHIK 216596031697 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 216596031698 active site 1 [active] 216596031699 dimer interface [polypeptide binding]; other site 216596031700 hexamer interface [polypeptide binding]; other site 216596031701 active site 2 [active] 216596031702 Pfam match to entry PF01361.9 Tautomerase 216596031703 10 probable transmembrane helices predicted at aa 7-29, 39-56, 69-86, 90-112,124-146, 156-175, 188-210, 230-252, 259-281 and 286-308 216596031704 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 216596031705 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 216596031706 Pfam match to entry PF01609.9 Transposase_11 216596031707 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 216596031708 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 216596031709 Putative transposase; Region: Y2_Tnp; pfam04986 216596031710 Pfam match to entry PF04986.3 Transposase_32 216596031711 integron integrase; Region: integrase_gron; TIGR02249 216596031712 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 216596031713 Int/Topo IB signature motif; other site 216596031714 Pfam match to entry PF00589.8 Phage_integrase 216596031715 Pfam match to entry PF02899.5 Phage_integr_N 216596031716 1 probable transmembrane helix predicted at aa 53-75 216596031717 Protein of unknown function (DUF982); Region: DUF982; pfam06169 216596031718 Pfam match to entry PF06169.1 DUF982 216596031719 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 216596031720 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 216596031721 active site 216596031722 ATP binding site [chemical binding]; other site 216596031723 substrate binding site [chemical binding]; other site 216596031724 activation loop (A-loop); other site 216596031725 1 probable transmembrane helix predicted at aa 311-333 216596031726 Serpin (serine protease inhibitor); Region: Serpin; pfam00079 216596031727 reactive center loop; other site 216596031728 Pfam match to entry PF00079.8 Serpin 216596031729 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 216596031730 cleavage site 216596031731 active site 216596031732 substrate binding sites [chemical binding]; other site 216596031733 Caspase domain; Region: Peptidase_C14; pfam00656 216596031734 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 216596031735 Pfam match to entry PF00656.9 Peptidase_C14 216596031736 Pfam match to entry PF00089.9 Trypsin 216596031737 Caspase domain; Region: Peptidase_C14; pfam00656 216596031738 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 216596031739 Pfam match to entry PF00656.9 Peptidase_C14 216596031740 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 216596031741 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 216596031742 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 216596031743 ligand binding site [chemical binding]; other site 216596031744 Pfam match to entry PF00691.7 OmpA 216596031745 Pfam match to entry PF00877.8 NLPC_P60 216596031746 Phospholipid methyltransferase; Region: PEMT; cl17370 216596031747 9 probable transmembrane helices predicted at aa 5-22, 26-48, 73-95, 105-127,156-178, 205-227, 239-261, 276-298 and 329-351 216596031748 Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249 216596031749 Caspase domain; Region: Peptidase_C14; pfam00656 216596031750 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 216596031751 Sel1-like repeats; Region: SEL1; smart00671 216596031752 Sel1-like repeats; Region: SEL1; smart00671 216596031753 Sel1-like repeats; Region: SEL1; smart00671 216596031754 Pfam match to entry PF00656.9 Peptidase_C14 216596031755 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 216596031756 Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324 216596031757 putative active site pocket [active] 216596031758 metal binding site [ion binding]; metal-binding site 216596031759 Pfam match to entry PF01188.9 MR_MLE 216596031760 short chain dehydrogenase; Provisional; Region: PRK07063 216596031761 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 216596031762 NAD binding site [chemical binding]; other site 216596031763 homotetramer interface [polypeptide binding]; other site 216596031764 homodimer interface [polypeptide binding]; other site 216596031765 active site 216596031766 Pfam match to entry PF00106.11 adh_short 216596031767 Transcriptional regulator [Transcription]; Region: IclR; COG1414 216596031768 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 216596031769 Bacterial transcriptional regulator; Region: IclR; pfam01614 216596031770 Predicted helix-turn-helix motif with score 1364.000, SD 3.83 at aa 31-52, sequence LTQAEIAKRLDRSPNEFYRMLD 216596031771 Pfam match to entry PF01614.6 IclR 216596031772 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 216596031773 Amidohydrolase; Region: Amidohydro_2; pfam04909 216596031774 active site 216596031775 Pfam match to entry PF04909.2 Amidohydro_2 216596031776 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 216596031777 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 216596031778 non-specific DNA binding site [nucleotide binding]; other site 216596031779 salt bridge; other site 216596031780 sequence-specific DNA binding site [nucleotide binding]; other site 216596031781 Pfam match to entry PF01381.9 HTH_3 216596031782 Predicted helix-turn-helix motif with score 1938.000, SD 5.79 at aa 25-46, sequence VSQTELGDRVGVTFQQIQKYEK 216596031783 TfuA-like protein; Region: TfuA; pfam07812 216596031784 Uncharacterized conserved protein [Function unknown]; Region: COG1944 216596031785 YcaO-like family; Region: YcaO; pfam02624 216596031786 Pfam match to entry PF02624.4 YcaO 216596031787 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 216596031788 Predicted integral membrane protein [Function unknown]; Region: COG5616 216596031789 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216596031790 binding surface 216596031791 TPR motif; other site 216596031792 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 216596031793 binding surface 216596031794 TPR repeat; Region: TPR_11; pfam13414 216596031795 TPR motif; other site 216596031796 Pfam match to entry PF00515.12 TPR 216596031797 Pfam match to entry PF00515.12 TPR 216596031798 Pfam match to entry PF03704.4 BTAD 216596031799 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 216596031800 Transposase; Region: DEDD_Tnp_IS110; pfam01548 216596031801 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 216596031802 Pfam match to entry PF01548.6 Transposase_9 216596031803 Pfam match to entry PF02371.5 Transposase_20 216596031804 cytosine deaminase-like protein; Validated; Region: PRK07583 216596031805 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 216596031806 active site 216596031807 Transcriptional regulator [Transcription]; Region: LysR; COG0583 216596031808 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 216596031809 LysR substrate binding domain; Region: LysR_substrate; pfam03466 216596031810 dimerization interface [polypeptide binding]; other site 216596031811 Pfam match to entry PF03466.5 LysR_substrate 216596031812 Pfam match to entry PF00126.10 HTH_1 216596031813 Predicted helix-turn-helix motif with score 1354.000, SD 3.80 at aa 40-61, sequence GSIRKAAKTLHVAASAVNRYIL 216596031814 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 216596031815 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 216596031816 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 216596031817 Pfam match to entry PF03171.7 2OG-FeII_Oxy 216596031818 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 216596031819 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 216596031820 dimer interface [polypeptide binding]; other site 216596031821 conserved gate region; other site 216596031822 putative PBP binding loops; other site 216596031823 ABC-ATPase subunit interface; other site 216596031824 Pfam match to entry PF00528.10 BPD_transp_1 216596031825 7 probable transmembrane helices predicted at aa 13-35, 39-61, 70-92, 107-129,134-156, 195-217 and 230-252 216596031826 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 216596031827 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 216596031828 Walker A/P-loop; other site 216596031829 ATP binding site [chemical binding]; other site 216596031830 Q-loop/lid; other site 216596031831 ABC transporter signature motif; other site 216596031832 Walker B; other site 216596031833 D-loop; other site 216596031834 H-loop/switch region; other site 216596031835 Pfam match to entry PF00005.11 ABC_tran 216596031836 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 216596031837 NMT1/THI5 like; Region: NMT1; pfam09084 216596031838 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106 216596031839 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 216596031840 dimerization interface [polypeptide binding]; other site 216596031841 active site 216596031842 Pfam match to entry PF01729.8 QRPTase_C 216596031843 Pfam match to entry PF02749.5 QRPTase_N 216596031844 L-aspartate oxidase; Provisional; Region: PRK07512 216596031845 L-aspartate oxidase; Provisional; Region: PRK06175 216596031846 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 216596031847 Pfam match to entry PF02910.6 Succ_DH_flav_C 216596031848 Pfam match to entry PF00890.10 FAD_binding_2 216596031849 quinolinate synthetase; Provisional; Region: PRK09375 216596031850 Pfam match to entry PF02445.5 NadA 216596031851 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 216596031852 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 216596031853 Pfam match to entry PF02548.4 Pantoate_transf 216596031854 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 216596031855 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 216596031856 Pfam match to entry PF00070.12 Pyr_redox 216596031857 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 216596031858 [2Fe-2S] cluster binding site [ion binding]; other site 216596031859 Pfam match to entry PF00355.13 Rieske 216596031860 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 216596031861 This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511 216596031862 putative di-iron ligands [ion binding]; other site 216596031863 Pfam match to entry PF00487.11 FA_desaturase 216596031864 3 probable transmembrane helices predicted at aa 56-78, 158-176 and 209-231 216596031865 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 216596031866 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 216596031867 DNA binding site [nucleotide binding] 216596031868 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 216596031869 putative ligand binding site [chemical binding]; other site 216596031870 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 216596031871 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 216596031872 active site 216596031873 SAM binding site [chemical binding]; other site 216596031874 homodimer interface [polypeptide binding]; other site 216596031875 Pfam match to entry PF00590.7 TP_methylase 216596031876 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 216596031877 active site 216596031878 putative homodimer interface [polypeptide binding]; other site 216596031879 SAM binding site [chemical binding]; other site 216596031880 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 216596031881 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 216596031882 S-adenosylmethionine binding site [chemical binding]; other site 216596031883 Pfam match to entry PF00590.7 TP_methylase 216596031884 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 216596031885 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 216596031886 Pfam match to entry PF02571.4 CbiJ 216596031887 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 216596031888 active site 216596031889 SAM binding site [chemical binding]; other site 216596031890 homodimer interface [polypeptide binding]; other site 216596031891 Pfam match to entry PF00590.7 TP_methylase 216596031892 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 216596031893 active site 216596031894 SAM binding site [chemical binding]; other site 216596031895 homodimer interface [polypeptide binding]; other site 216596031896 Pfam match to entry PF00590.7 TP_methylase 216596031897 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 216596031898 Precorrin-8X methylmutase; Region: CbiC; pfam02570 216596031899 Pfam match to entry PF02570.4 CbiC 216596031900 precorrin-3B synthase; Region: CobG; TIGR02435 216596031901 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 216596031902 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 216596031903 Pfam match to entry PF03460.3 NIR_SIR_ferr 216596031904 Pfam match to entry PF03460.3 NIR_SIR_ferr 216596031905 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 216596031906 active site 216596031907 SAM binding site [chemical binding]; other site 216596031908 homodimer interface [polypeptide binding]; other site 216596031909 Pfam match to entry PF00590.7 TP_methylase