-- dump date 20140620_025220 -- class Genbank::CDS -- table cds_note -- id note YP_001166218.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase YP_001166219.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself. YP_001166220.1 binds the polymerase to DNA and acts as a sliding clamp YP_001166221.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA YP_001166222.1 PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase YP_001166223.1 negatively supercoils closed circular double-stranded DNA YP_001166224.1 PFAM: AFG1-family ATPase YP_001166225.1 TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase domain protein hydrolase YP_001166226.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate YP_001166227.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate YP_001166228.1 PFAM: metallophosphoesterase YP_001166229.1 catalyzes the formation of beta-ketovaleryl-CoA from acetyl-CoA and propionyl-CoA YP_001166230.1 TIGRFAM: penicillin-binding protein 1C; PFAM: glycosyl transferase, family 51; penicillin-binding protein, transpeptidase; Penicillin-binding domain protein YP_001166231.1 PFAM: alpha-2-macroglobulin domain protein; N/apple PAN domain protein; alpha-2-macroglobulin domain protein 2; SMART: Apple YP_001166232.1 PFAM: response regulator receiver; ATP-binding region, ATPase domain protein; histidine kinase A domain protein YP_001166233.1 PFAM: protein of unknown function DUF328 YP_001166234.1 TIGRFAM: ATP-dependent DNA helicase, RecQ family; ATP-dependent DNA helicase RecQ; PFAM: helicase domain protein; HRDC domain protein; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases-like YP_001166235.1 PFAM: protein of unknown function YGGT YP_001166237.1 PFAM: major facilitator superfamily MFS_1 YP_001166238.1 D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm YP_001166240.1 TIGRFAM: conserved hypothetical integral membrane protein; PFAM: protein of unknown function DUF165 YP_001166241.1 PFAM: Class I peptide chain release factor YP_001166242.1 catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate YP_001166243.1 PFAM: isochorismatase hydrolase YP_001166244.1 PFAM: short-chain dehydrogenase/reductase SDR; KR YP_001166245.1 PFAM: 2-keto-3-deoxy-galactonokinase YP_001166246.1 PFAM: alpha amylase, catalytic region; SMART: alpha amylase, catalytic sub domain YP_001166247.1 PFAM: major facilitator superfamily MFS_1 YP_001166248.1 PFAM: major facilitator superfamily MFS_1 YP_001166249.1 PFAM: glycosyl transferase, group 1 YP_001166251.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde YP_001166253.1 PFAM: carbonic anhydrase YP_001166255.1 PFAM: peptidase M17, leucyl aminopeptidase domain protein YP_001166256.1 PFAM: NLP/P60 protein YP_001166257.1 PFAM: protein of unknown function DUF1006 YP_001166258.1 TIGRFAM: radical SAM enzyme, Cfr family; PFAM: Radical SAM domain protein YP_001166260.1 PFAM: L-asparaginase II YP_001166262.1 PFAM: conserved hypothetical protein 730 YP_001166263.1 catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway YP_001166265.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica. YP_001166266.1 PFAM: GCN5-related N-acetyltransferase YP_001166267.1 TIGRFAM: VacB and RNase II family 3'-5' exoribonuclease; ribonuclease R; PFAM: ribonuclease II; RNA binding S1 domain protein YP_001166268.1 TIGRFAM: lytic murein transglycosylase; PFAM: Peptidoglycan-binding domain 1 protein YP_001166270.1 PFAM: Integrase, catalytic region YP_001166276.1 PFAM: Three-deoxy-D-manno-octulosonic-acid transferase domain protein YP_001166277.1 transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate YP_001166278.1 PFAM: L-carnitine dehydratase/bile acid-inducible protein F YP_001166279.1 PFAM: DSBA oxidoreductase YP_001166280.1 PFAM: protein of unknown function DUF1159 YP_001166281.1 TIGRFAM: A/G-specific adenine glycosylase; PFAM: helix-hairpin-helix motif; HhH-GPD family protein YP_001166282.1 PFAM: fatty acid desaturase YP_001166283.1 PFAM: DNA methylase N-4/N-6 domain protein YP_001166284.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids YP_001166285.1 PFAM: protein of unknown function DUF37 YP_001166286.1 TIGRFAM: ribonuclease P protein component; PFAM: ribonuclease P protein YP_001166287.1 in Escherichia coli transcription of this gene is enhanced by polyamines YP_001166288.1 PFAM: ribosomal protein S16 YP_001166289.1 PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; FAD dependent oxidoreductase YP_001166290.1 PFAM: ATP-binding region, ATPase domain protein; histidine kinase, HAMP region domain protein; histidine kinase A domain protein YP_001166291.1 TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; pyridine nucleotide-disulphide oxidoreductase dimerisation region YP_001166292.1 component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of acetyl from acetyldihydrolipoamide to coenzyme A to form acetyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA YP_001166293.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide YP_001166294.1 TIGRFAM: succinyl-CoA synthetase, alpha subunit; PFAM: CoA-binding domain protein; ATP-citrate lyase/succinyl-CoA ligase YP_001166295.1 catalyzes the interconversion of succinyl-CoA and succinate YP_001166296.1 Catalyzes the reversible oxidation of malate to oxaloacetate YP_001166297.1 PFAM: protein of unknown function DUF81 YP_001166298.1 PFAM: HpcH/HpaI aldolase YP_001166299.1 PFAM: NnrU family protein YP_001166301.1 PFAM: MaoC domain protein dehydratase YP_001166302.1 PFAM: succinate dehydrogenase, cytochrome b subunit YP_001166304.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol YP_001166307.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase YP_001166309.1 PFAM: regulatory protein GntR, HTH; GntR domain protein YP_001166310.1 PFAM: protein of unknown function DUF45 YP_001166320.1 PFAM: peptidase S49 YP_001166328.1 PFAM: phage integrase family protein YP_001166330.1 TIGRFAM: type I secretion membrane fusion protein, HlyD family; PFAM: secretion protein HlyD family protein YP_001166331.1 TIGRFAM: type I secretion system ATPase; PFAM: ABC transporter related; SMART: AAA ATPase YP_001166332.1 PFAM: VacJ family lipoprotein YP_001166333.1 PFAM: toluene tolerance family protein YP_001166334.1 TIGRFAM: penicillin-binding protein, 1A family; PFAM: glycosyl transferase, family 51; penicillin-binding protein, transpeptidase YP_001166335.1 PFAM: nitrogen regulatory protein P-II YP_001166336.1 TIGRFAM: ammonium transporter; PFAM: Rh family protein/ammonium transporter YP_001166337.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate YP_001166338.1 PFAM: Rhodanese domain protein YP_001166339.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation YP_001166340.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis YP_001166341.1 PFAM: Lytic transglycosylase, catalytic; Tetratricopeptide TPR_4 YP_001166347.1 PFAM: phage terminase GpA YP_001166348.1 SMART: helix-turn-helix domain protein YP_001166352.1 TIGRFAM: phage portal protein, lambda family; PFAM: phage portal protein, lambda YP_001166353.1 PFAM: peptidase U35, phage prohead HK97 YP_001166356.1 PFAM: phage integrase family protein YP_001166357.1 PFAM: FAD dependent oxidoreductase YP_001166358.1 PFAM: protein of unknown function DUF752 YP_001166359.1 PFAM: protein of unknown function DUF6, transmembrane YP_001166360.1 TIGRFAM: chromosome segregation protein SMC; PFAM: SMC domain protein; SMCs flexible hinge domain protein YP_001166361.1 PFAM: response regulator receiver YP_001166363.1 PFAM: aminotransferase, class I and II YP_001166364.1 TIGRFAM: peptide deformylase; PFAM: formylmethionine deformylase YP_001166365.1 TIGRFAM: peptide deformylase; PFAM: formylmethionine deformylase YP_001166366.1 TIGRFAM: peptide deformylase; PFAM: formylmethionine deformylase YP_001166367.1 TIGRFAM: methionyl-tRNA formyltransferase; PFAM: formyl transferase domain protein YP_001166370.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids YP_001166371.1 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA YP_001166372.1 TIGRFAM: iojap-like protein; PFAM: Iojap-related protein YP_001166373.1 PFAM: SOUL heme-binding protein YP_001166374.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate YP_001166375.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D YP_001166377.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis YP_001166378.1 PFAM: protein of unknown function DUF6, transmembrane YP_001166383.1 PFAM: transposase, IS4 family protein YP_001166385.1 PFAM: IS66 Orf2 family protein YP_001166386.1 PFAM: transposase IS66 YP_001166388.1 PFAM: transposase, IS4 family protein YP_001166390.1 PFAM: protein of unknown function DUF805 YP_001166391.1 TIGRFAM: signal recognition particle protein; PFAM: GTP-binding signal recognition particle SRP54, G- domain; Signal peptide binding (SRP54) M- domain protein; GTP-binding signal recognition particle SRP54, helical bundle; SMART: AAA ATPase YP_001166393.1 PFAM: GCN5-related N-acetyltransferase YP_001166394.1 PFAM: GCN5-related N-acetyltransferase YP_001166395.1 catalyzes the interconversion of chorismate to prephenate YP_001166396.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity YP_001166397.1 Essential for efficient processing of 16S rRNA YP_001166399.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA YP_001166400.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site YP_001166401.1 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome YP_001166403.1 PFAM: regulatory protein, ArsR YP_001166405.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 YP_001166406.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0 YP_001166407.1 produces ATP from ADP in the presence of a proton gradient across the membrane; subunit B' is part of the membrane proton channel. YP_001166408.1 produces ATP from ADP in the presence of a proton gradient across the membrane; subunit B is part of the membrane proton channel. YP_001166409.1 PFAM: regulatory protein GntR, HTH; GntR domain protein; Helix-turn-helix, type 11 domain protein YP_001166410.1 PFAM: OmpA/MotB domain protein YP_001166411.1 TIGRFAM: methylated-DNA--protein-cysteine methyltransferase; PFAM: helix-turn-helix- domain containing protein, AraC type; methylated-DNA-[protein]-cysteine S-methyltransferase YP_001166412.1 TIGRFAM: endonuclease III; PFAM: helix-hairpin-helix motif; HhH-GPD family protein; SMART: iron-sulfur cluster loop YP_001166413.1 PFAM: PfkB domain protein YP_001166414.1 PFAM: histidine triad (HIT) protein YP_001166415.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair YP_001166417.1 PFAM: protein of unknown function DUF1285 YP_001166418.1 PFAM: ATPase associated with various cellular activities, AAA_3; ATPase associated with various cellular activities, AAA_5 YP_001166420.1 TIGRFAM: conserved hypothetical membrane protein YP_001166423.1 PFAM: FAD linked oxidase domain protein YP_001166424.1 PFAM: FAD linked oxidase domain protein YP_001166425.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; protein of unknown function DUF224, cysteine-rich region domain protein YP_001166426.1 PFAM: peptidase S1 and S6, chymotrypsin/Hap YP_001166427.1 PFAM: heat shock protein Hsp20 YP_001166428.1 TIGRFAM: succinic semialdehyde dehydrogenase; PFAM: aldehyde dehydrogenase YP_001166429.1 TIGRFAM: glutamate--cysteine ligase; PFAM: glutamate--cysteine ligase, GCS2 YP_001166431.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase YP_001166432.1 UbiA prenyltransferase family catalyzes the transfer of a prenyl group to various acceptors with hydrophobic ring structures in the biosynthesis of respiratory quinones, hemes, chlorophylls, vitamin E, and shikonin YP_001166433.1 PFAM: OmpA/MotB domain protein YP_001166436.1 PFAM: protein of unknown function DUF205 YP_001166437.1 TIGRFAM: dihydroorotase, multifunctional complex type; PFAM: amidohydrolase YP_001166438.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis YP_001166439.1 TIGRFAM: phage SPO1 DNA polymerase-related protein; PFAM: Uracil-DNA glycosylase superfamily YP_001166441.1 PFAM: protein of unknown function DUF179 YP_001166442.1 PFAM: Na+/H+ antiporter subunit YP_001166443.1 PFAM: multiple resistance and pH regulation protein F YP_001166444.1 subunit E of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in S. meliloti it is known to be involved specifically with K+ transport YP_001166445.1 subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone YP_001166446.1 subunit C of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_001166447.1 subunit A of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in S. meliloti it is known to be involved with K+ YP_001166448.1 PFAM: ROK family protein YP_001166449.1 PFAM: periplasmic binding protein/LacI transcriptional regulator YP_001166450.1 PFAM: inner-membrane translocator YP_001166451.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001166453.1 PFAM: protein of unknown function DUF6, transmembrane YP_001166454.1 TIGRFAM: adenine deaminase; PFAM: amidohydrolase YP_001166456.1 TIGRFAM: TRAP dicarboxylate transporter, DctM subunit; PFAM: TRAP C4-dicarboxylate transport system permease DctM subunit YP_001166457.1 PFAM: Tripartite ATP-independent periplasmic transporter, DctQ component YP_001166458.1 TIGRFAM: TRAP dicarboxylate transporter, DctP subunit; PFAM: TRAP dicarboxylate transporter- DctP subunit YP_001166459.1 TIGRFAM: PAS sensor protein; PFAM: ATP-binding region, ATPase domain protein; histidine kinase A domain protein; PAS fold-3 domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein; PAC repeat-containing protein YP_001166460.1 PFAM: regulatory protein, LuxR; response regulator receiver; Sigma-70, region 4 type 2 YP_001166461.1 PFAM: ABC-3 protein YP_001166462.1 PFAM: transport system permease protein; ABC-3 protein YP_001166463.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001166464.1 PFAM: periplasmic solute binding protein YP_001166465.1 PFAM: Endoribonuclease L-PSP YP_001166466.1 PFAM: glycerophosphoryl diester phosphodiesterase YP_001166467.1 PFAM: protein of unknown function DUF482 YP_001166468.1 PFAM: Glutathione S-transferase, N-terminal domain YP_001166469.1 PFAM: transcriptional coactivator/pterin dehydratase YP_001166470.1 in Rhizobium meliloti this protein is involved in the synthesis of nodulation factors that are active on the roots of alfalfa; catalyzes formation of activated sulfate intermediate; converts ATP and sulfate to diphosphate and adenylylsulfate and then ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; the activated intermediate is transferred to the nodulation factors by NodH; may interact with NodP and NodQ; similar to the CysD and CysN proteins from Escherichia coli involved in cysteine biosynthesis YP_001166471.1 TIGRFAM: thioredoxin reductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase YP_001166472.1 PFAM: regulatory protein, AsnC/Lrp family YP_001166473.1 PFAM: protein of unknown function DUF152 YP_001166474.1 PFAM: protein of unknown function DUF185 YP_001166475.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein YP_001166476.1 PFAM: protein of unknown function DUF526 YP_001166478.1 PFAM: response regulator receiver YP_001166479.1 PFAM: CheW domain protein; ATP-binding region, ATPase domain protein; Signal transducing histidine kinase, homodimeric; Hpt domain protein YP_001166480.1 PFAM: CheW domain protein YP_001166481.1 PFAM: CheW domain protein YP_001166482.1 PFAM: MCP methyltransferase, CheR-type YP_001166483.1 PFAM: CheB methylesterase; response regulator receiver YP_001166486.1 PFAM: response regulator receiver; sigma-54 factor, interaction domain-containing protein; helix-turn-helix, Fis-type; SMART: AAA ATPase YP_001166488.1 PFAM: AMP-dependent synthetase and ligase YP_001166489.1 NAD-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; does not decarboxylate oxaloacetate YP_001166490.1 TIGRFAM: cytidine deaminase; PFAM: CMP/dCMP deaminase, zinc-binding YP_001166491.1 Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate YP_001166492.1 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose YP_001166493.1 catalyzes the formation of inosine from adenosine YP_001166494.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate YP_001166495.1 PFAM: Sporulation domain protein YP_001166497.1 PFAM: AMP-dependent synthetase and ligase YP_001166498.1 PFAM: protein of unknown function DUF6, transmembrane YP_001166499.1 PFAM: Methyltransferase type 11 YP_001166500.1 PFAM: regulatory protein GntR, HTH; GntR domain protein YP_001166501.1 PFAM: Alcohol dehydrogenase, zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein YP_001166502.1 PFAM: D-galactarate dehydratase/Altronate hydrolase domain protein; SAF domain YP_001166503.1 PFAM: ATP-binding region, ATPase domain protein; histidine kinase A domain protein YP_001166504.1 PFAM: response regulator receiver; sigma-54 factor, interaction domain-containing protein; helix-turn-helix, Fis-type; SMART: AAA ATPase YP_001166505.1 TIGRFAM: TRAP transporter solute receptor, TAXI family YP_001166506.1 TIGRFAM: TRAP transporter, 4TM/12TM fusion protein; PFAM: TRAP C4-dicarboxylate transport system permease DctM subunit YP_001166508.1 Catalyzes the deamination of guanine YP_001166509.1 TIGRFAM: magnesium transporter; PFAM: CBS domain containing protein; MgtE integral membrane region; MgtE intracellular region YP_001166510.1 PFAM: 5-formyltetrahydrofolate cyclo-ligase YP_001166514.1 PFAM: TPR repeat-containing protein; Tetratricopeptide TPR_2 repeat protein; SMART: Tetratricopeptide domain protein YP_001166515.1 PFAM: type II secretion system protein YP_001166516.1 PFAM: type II secretion system protein YP_001166517.1 PFAM: type II secretion system protein E YP_001166519.1 PFAM: OmpA/MotB domain protein YP_001166520.1 PFAM: type II and III secretion system protein; transport-associated YP_001166521.1 PFAM: Lytic transglycosylase, catalytic YP_001166528.1 PFAM: IstB domain protein ATP-binding protein; SMART: AAA ATPase YP_001166532.1 TIGRFAM: TIM-barrel protein, yjbN family; PFAM: dihydrouridine synthase, DuS YP_001166533.1 PFAM: protein of unknown function DUF81 YP_001166534.1 unwinds double stranded DNA YP_001166535.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate YP_001166536.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis YP_001166537.1 PFAM: metal-dependent phosphohydrolase, HD sub domain YP_001166538.1 PFAM: ATPase associated with various cellular activities, AAA_5; SMART: AAA ATPase YP_001166539.1 PFAM: VWA containing CoxE family protein; SMART: von Willebrand factor, type A YP_001166541.1 PFAM: OmpA/MotB domain protein YP_001166542.1 PFAM: protein of unknown function DUF182 YP_001166543.1 PFAM: molybdopterin binding domain YP_001166544.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits YP_001166546.1 PFAM: Oxidoreductase FAD-binding domain protein YP_001166548.1 catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite YP_001166549.1 PFAM: nitrite/sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein; nitrite and sulphite reductase 4Fe-4S region YP_001166551.1 TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase YP_001166552.1 PFAM: regulatory protein, AsnC/Lrp family YP_001166553.1 PFAM: cytochrome P450 YP_001166554.1 PFAM: triosephosphate isomerase YP_001166555.1 TIGRFAM: iron-sulfur cluster assembly accessory protein; PFAM: HesB/YadR/YfhF-family protein YP_001166556.1 PFAM: protein of unknown function DUF59 YP_001166557.1 PFAM: metallophosphoesterase YP_001166559.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 YP_001166560.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis YP_001166561.1 PFAM: FMN-dependent alpha-hydroxy acid dehydrogenase YP_001166562.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response YP_001166563.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation YP_001166564.1 catalyzes the phosphorylation of NAD to NADP YP_001166565.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate YP_001166567.1 PFAM: alpha/beta hydrolase fold YP_001166568.1 PFAM: cytochrome B561 YP_001166570.1 PFAM: helicase domain protein; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases-like YP_001166571.1 PFAM: Hemolysin-type calcium-binding region YP_001166572.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity YP_001166573.1 catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine YP_001166575.1 PFAM: Abortive infection protein YP_001166576.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes YP_001166577.1 PFAM: GCN5-related N-acetyltransferase YP_001166578.1 PFAM: response regulator receiver YP_001166579.1 PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase YP_001166580.1 PFAM: protein of unknown function DUF1467 YP_001166582.1 PFAM: nitroreductase YP_001166583.1 PFAM: extracellular solute-binding protein, family 5 YP_001166584.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001166585.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001166586.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001166587.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001166588.1 PFAM: peptidase M19, renal dipeptidase YP_001166589.1 PFAM: histone deacetylase superfamily YP_001166590.1 PFAM: protein of unknown function DUF167 YP_001166591.1 PFAM: beta-lactamase domain protein YP_001166592.1 PFAM: protein of unknown function DUF1025 YP_001166593.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_001166595.1 catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation YP_001166596.1 PFAM: regulatory protein, LysR; LysR, substrate-binding YP_001166597.1 Required for coenzyme pyrroloquinoline quinone (PQQ) biosynthesis; probably provides the glutamate and tyrosine residues that are cross-linked and modified to form the coenzyme YP_001166598.1 possibly involved in transport of pyrroloquinoline quinone transport YP_001166599.1 Required in the synthesis of PPQ, but its exact function is unknown YP_001166600.1 PFAM: coenzyme PQQ synthesis D YP_001166601.1 TIGRFAM: coenzyme PQQ biosynthesis protein E; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB YP_001166602.1 PFAM: aminotransferase, class I and II YP_001166605.1 PFAM: Endonuclease/exonuclease/phosphatase YP_001166606.1 PFAM: heat shock protein DnaJ domain protein YP_001166607.1 PFAM: GCN5-related N-acetyltransferase YP_001166608.1 PFAM: Ppx/GppA phosphatase YP_001166609.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate YP_001166610.1 PFAM: Chromosomal replication initiator, DnaA YP_001166611.1 PFAM: protein of unknown function UPF0118 YP_001166612.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) YP_001166613.1 TIGRFAM: lipoprotein releasing system, transmembrane protein, LolC/E family; PFAM: protein of unknown function DUF214 YP_001166614.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001166616.1 PFAM: RNA binding S1 domain protein; SMART: Resolvase, RNase H domain protein fold YP_001166617.1 catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate YP_001166618.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_001166619.1 PFAM: regulatory protein, LuxR YP_001166620.1 PFAM: protein of unknown function DUF344 YP_001166622.1 TIGRFAM: MATE efflux family protein; PFAM: multi antimicrobial extrusion protein MatE YP_001166623.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate YP_001166624.1 PFAM: helix-turn-helix domain protein YP_001166625.1 PFAM: protein of unknown function DUF339 YP_001166626.1 PFAM: regulatory protein, MarR YP_001166627.1 PFAM: polysaccharide export protein YP_001166628.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine YP_001166631.1 PFAM: 3,4-dihydroxy-2-butanone 4-phosphate synthase; GTP cyclohydrolase II YP_001166632.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not YP_001166633.1 TIGRFAM: transcription antitermination factor NusB; PFAM: NusB/RsmB/TIM44 YP_001166635.1 PFAM: protein of unknown function DUF481 YP_001166636.1 PFAM: protein of unknown function DUF1052 YP_001166638.1 PFAM: GCN5-related N-acetyltransferase YP_001166642.1 PFAM: transposase IS66 YP_001166643.1 PFAM: IS66 Orf2 family protein YP_001166644.1 PFAM: transposase IS3/IS911 family protein YP_001166660.1 PFAM: glycoside hydrolase, family 24 YP_001166662.1 TIGRFAM: single-strand binding protein; PFAM: single-strand binding protein/Primosomal replication protein n YP_001166663.1 PFAM: Lytic transglycosylase, catalytic YP_001166664.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001166665.1 PFAM: superoxide dismutase, copper/zinc binding YP_001166666.1 TIGRFAM: preprotein translocase, YajC subunit; PFAM: YajC family protein YP_001166667.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane YP_001166668.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF YP_001166669.1 PFAM: protein of unknown function DUF498 YP_001166670.1 ATP-binding protein; required for proper cytochrome c maturation YP_001166671.1 TIGRFAM: heme exporter protein CcmB; PFAM: cytochrome c-type biogenesis protein CcmB YP_001166672.1 TIGRFAM: heme exporter protein CcmC; PFAM: cytochrome c assembly protein YP_001166673.1 PFAM: Heme exporter protein D (CcmD) YP_001166674.1 TIGRFAM: periplasmic protein thiol--disulphide oxidoreductase DsbE; PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; Redoxin domain protein; Thioredoxin domain YP_001166675.1 Catalyzes the conversion of citrate to isocitrate YP_001166676.1 PFAM: protein of unknown function DUF1223 YP_001166677.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001166678.1 PFAM: Rhomboid family protein YP_001166679.1 TIGRFAM: integral membrane protein MviN; PFAM: virulence factor MVIN family protein YP_001166680.1 catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein YP_001166682.1 PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase YP_001166683.1 PFAM: protein of unknown function UPF0102 YP_001166684.1 catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione YP_001166685.1 PFAM: transposase, IS111A/IS1328/IS1533; transposase IS116/IS110/IS902 family protein YP_001166689.1 PFAM: transposase, IS4 family protein YP_001166691.1 PFAM: Phosphoglycerate mutase YP_001166692.1 PFAM: cobalbumin biosynthesis enzyme YP_001166693.1 binds with the catalytic core of RNA polymerase to produce the holoenzyme; sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma-32 is responsible for the expression of heat shock promoters; there are paralogs in Rhizobium and Sinorhizobium; the proteins in this cluster act as secondary heat shock sigma factors; the Rhizobium sigma-32 factor may also be involved in exopolysaccharide production YP_001166695.1 catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine YP_001166696.1 TIGRFAM: D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase; PFAM: peptidase S13, D-Ala-D-Ala carboxypeptidase C YP_001166698.1 class I; LysRS1; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri this enzyme charges both tRNA molecules for lysine that exist in this organism (but the tRNALysUUU very poorly) and in the presence of LysRS2 can charge tRNAPyl with lysine YP_001166699.1 PFAM: OsmC family protein YP_001166700.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria YP_001166701.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence YP_001166706.1 PFAM: Cold-shock protein, DNA-binding; SMART: Cold shock protein YP_001166707.1 PFAM: sulfatase YP_001166708.1 PFAM: CDP-alcohol phosphatidyltransferase YP_001166709.1 PFAM: protein of unknown function DUF6, transmembrane YP_001166710.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme YP_001166711.1 PFAM: conserved hypothetical protein 1620 YP_001166712.1 PFAM: protein of unknown function DUF463, YcjX family protein YP_001166713.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability YP_001166714.1 TIGRFAM: DNA polymerase III, epsilon subunit; PFAM: Exonuclease, RNase T and DNA polymerase III; SMART: Exonuclease YP_001166715.1 PFAM: response regulator receiver YP_001166717.1 PFAM: cyclic nucleotide-binding; CBS domain containing protein; protein of unknown function DUF294, nucleotidyltransferase putative YP_001166718.1 PFAM: Na+/solute symporter YP_001166720.1 PFAM: adenylate kinase; adenylate kinase, lid domain protein YP_001166721.1 TIGRFAM: acetate--CoA ligase; PFAM: AMP-dependent synthetase and ligase YP_001166722.1 PFAM: Sulfate transporter/antisigma-factor antagonist STAS; Xanthine/uracil/vitamin C permease; sulphate transporter YP_001166723.1 PFAM: pyridoxamine 5'-phosphate oxidase-related, FMN-binding YP_001166724.1 PFAM: UBA/THIF-type NAD/FAD binding protein; MoeZ/MoeB domain protein YP_001166725.1 PFAM: peptidase M3A and M3B, thimet/oligopeptidase F YP_001166726.1 PFAM: Lipocalin-related protein and Bos/Can/Equ allergen; Lipocalin family protein YP_001166727.1 PFAM: ribonuclease T2 YP_001166728.1 PFAM: protein of unknown function DUF1013 YP_001166730.1 involved in a recombinational process of DNA repair, independent of the recBC complex YP_001166731.1 PFAM: conserved hypothetical protein 103 YP_001166732.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA YP_001166733.1 PFAM: NUDIX hydrolase YP_001166735.1 catalyzes the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis YP_001166736.1 PFAM: cytochrome c, class I YP_001166737.1 PFAM: extracellular solute-binding protein, family 5 YP_001166738.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001166739.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001166740.1 PFAM: ABC transporter related; Oligopeptide/dipeptide ABC transporter, C-terminal domain protein; SMART: AAA ATPase YP_001166741.1 PFAM: glycosyl transferase, group 1 YP_001166742.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_001166743.1 PFAM: cyclic nucleotide-binding; regulatory protein, Crp YP_001166744.1 PFAM: UspA domain protein YP_001166745.1 CcoN; FixN YP_001166746.1 CcoO; FixO YP_001166747.1 PFAM: Cbb3-type cytochrome oxidase component YP_001166748.1 TIGRFAM: cytochrome c oxidase, cbb3-type, subunit III; PFAM: cytochrome c, class I YP_001166749.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein YP_001166750.1 PFAM: FixH family protein YP_001166751.1 TIGRFAM: ATPase, P-type (transporting), HAD superfamily, subfamily IC; copper-translocating P-type ATPase; heavy metal translocating P-type ATPase; PFAM: Haloacid dehalogenase domain protein hydrolase; Heavy metal transport/detoxification protein; E1-E2 ATPase-associated domain protein YP_001166752.1 TIGRFAM: cytochrome oxidase maturation protein, cbb3-type; PFAM: cytochrome oxidase maturation protein cbb3-type YP_001166753.1 PFAM: peptidase S11, D-alanyl-D-alanine carboxypeptidase 1; Sporulation domain protein YP_001166754.1 PFAM: Haloacid dehalogenase domain protein hydrolase YP_001166755.1 PFAM: ATP-dependent Clp protease adaptor protein ClpS YP_001166756.1 PFAM: methyltransferase small; Methyltransferase type 11; Methyltransferase type 12 YP_001166757.1 PFAM: short-chain dehydrogenase/reductase SDR; KR YP_001166759.1 catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis YP_001166761.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III YP_001166762.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis YP_001166764.1 PFAM: Auxin Efflux Carrier YP_001166765.1 PFAM: beta-lactamase domain protein YP_001166766.1 TIGRFAM: hydrolase, TatD family; PFAM: TatD-related deoxyribonuclease YP_001166767.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA YP_001166769.1 TIGRFAM: 4-hydroxybenzoyl-CoA thioesterase; PFAM: thioesterase superfamily protein YP_001166770.1 PFAM: MotA/TolQ/ExbB proton channel YP_001166771.1 PFAM: Biopolymer transport protein ExbD/TolR YP_001166773.1 forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA YP_001166774.1 TIGRFAM: OmpA domain protein; PFAM: OmpA/MotB domain protein YP_001166776.1 TIGRFAM: tRNA(Ile)-lysidine synthetase; PFAM: PP-loop domain protein YP_001166777.1 TIGRFAM: ATP-dependent metalloprotease FtsH; PFAM: peptidase M41; AAA ATPase, central domain protein; peptidase M41, FtsH extracellular; ATPase associated with various cellular activities, AAA_5; SMART: AAA ATPase YP_001166778.1 PFAM: Methyltransferase type 11; Methyltransferase type 12 YP_001166780.1 catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate YP_001166781.1 PFAM: Chorismate mutase YP_001166782.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate YP_001166783.1 PFAM: LytTr DNA-binding region YP_001166785.1 PFAM: helicase domain protein; DEAD/DEAH box helicase domain protein; DEAD/H associated domain protein; SMART: DEAD-like helicases-like YP_001166786.1 PFAM: metallophosphoesterase YP_001166787.1 PFAM: Citrate transporter; TrkA-C domain protein YP_001166788.1 PFAM: protein of unknown function DUF28 YP_001166789.1 PFAM: protein of unknown function DUF6, transmembrane YP_001166790.1 PFAM: UDP-glucose/GDP-mannose dehydrogenase YP_001166791.1 TIGRFAM: UDP-glucose 4-epimerase; PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; 3-beta hydroxysteroid dehydrogenase/isomerase; polysaccharide biosynthesis protein CapD; dTDP-4-dehydrorhamnose reductase; Male sterility C-terminal domain YP_001166792.1 PFAM: inositol monophosphatase YP_001166793.1 PFAM: Lytic transglycosylase, catalytic YP_001166794.1 PFAM: hydroxyethylthiazole kinase YP_001166795.1 TIGRFAM: thiamine-phosphate pyrophosphorylase; PFAM: thiamine monophosphate synthase YP_001166796.1 TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1 YP_001166798.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001166799.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001166800.1 PFAM: ATP-binding region, ATPase domain protein; MASE1 domain protein; histidine kinase, dimerisation/phosphoacceptor YP_001166802.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_001166804.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer YP_001166805.1 PFAM: uncharacterised conserved protein UCP032146 YP_001166806.1 PFAM: low molecular weight phosphotyrosine protein phosphatase YP_001166807.1 PFAM: protein of unknown function DUF1486 YP_001166809.1 PFAM: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase YP_001166810.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 YP_001166811.1 TIGRFAM: maf protein; PFAM: Maf family protein YP_001166813.1 PFAM: protein of unknown function DUF329 YP_001166815.1 PFAM: response regulator receiver YP_001166816.1 PFAM: protein of unknown function DUF892 YP_001166817.1 PFAM: manganese containing catalase YP_001166818.1 PFAM: protein of unknown function DUF378 YP_001166819.1 PFAM: alpha/beta hydrolase fold YP_001166820.1 PFAM: regulatory protein, LacI; periplasmic binding protein/LacI transcriptional regulator YP_001166821.1 TIGRFAM: phosphocarrier, HPr family; phosphoenolpyruvate-protein phosphotransferase; PFAM: phosphocarrier HPr protein; PEP-utilizing enzyme; phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; PEP-utilising enzyme, mobile region; PEP-utilising enzyme domain protein YP_001166822.1 PFAM: PfkB domain protein YP_001166823.1 TIGRFAM: PTS system, fructose-specific, IIB subunnit; PTS system, fructose subfamily, IIC subunit; PFAM: phosphotransferase system, EIIC; phosphotransferase system PTS, fructose-specific IIB subunit YP_001166824.1 PFAM: peptidase U62, modulator of DNA gyrase YP_001166825.1 PFAM: cytochrome c oxidase, subunit II; cytochrome C oxidase subunit II, transmembrane region YP_001166826.1 converts protoheme IX and farnesyl diphosphate to heme O YP_001166828.1 involved in the insertion of copper into subunit I of cytochrome C oxidase YP_001166829.1 PFAM: cytochrome c oxidase, subunit III YP_001166831.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine YP_001166832.1 PFAM: peptidase M16 domain protein YP_001166833.1 PFAM: GCN5-related N-acetyltransferase YP_001166835.1 PFAM: FAD linked oxidase domain protein YP_001166836.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis YP_001166837.1 Catalyzes the reversible phosphorolysis of 5'-deoxy-5'- methylthioadenosine (MTA) to adenine and 5-methylthio-D-ribose-1- phosphate YP_001166838.1 PFAM: flavin reductase domain protein, FMN-binding YP_001166839.1 PFAM: GCN5-related N-acetyltransferase YP_001166841.1 PFAM: Intracellular septation protein A YP_001166842.1 PFAM: protein of unknown function DUF6, transmembrane YP_001166843.1 TIGRFAM: signal recognition particle-docking protein FtsY; PFAM: GTP-binding signal recognition particle SRP54, G- domain; GTP-binding signal recognition particle SRP54, helical bundle; SMART: AAA ATPase YP_001166845.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides YP_001166846.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis YP_001166847.1 TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein YP_001166848.1 TIGRFAM: phosphoenolpyruvate-protein phosphotransferase; PFAM: PEP-utilizing enzyme; GAF domain protein; PEP-utilising enzyme, mobile region; PEP-utilising enzyme domain protein YP_001166849.1 TIGRFAM: O-succinylhomoserine sulfhydrylase; PFAM: aminotransferase, class V; Cys/Met metabolism pyridoxal-phosphate-dependent enzymes YP_001166850.1 similar protein in Methanocaldococcus converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate as the first step in methanopterin biosynthesis YP_001166851.1 PFAM: cation transporter YP_001166852.1 PFAM: Peptidoglycan-binding domain 1 protein YP_001166853.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_001166856.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_001166857.1 PFAM: cell wall hydrolase, SleB YP_001166858.1 PFAM: dihydroneopterin aldolase YP_001166859.1 TIGRFAM: dihydropteroate synthase; PFAM: dihydropteroate synthase, DHPS YP_001166860.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate YP_001166862.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis YP_001166863.1 PFAM: regulatory protein, AsnC/Lrp family YP_001166864.1 PFAM: regulatory protein, AsnC/Lrp family YP_001166865.1 PFAM: aminotransferase, class V; aromatic amino acid beta-eliminating lyase/threonine aldolase YP_001166866.1 TIGRFAM: Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; PFAM: monooxygenase, FAD-binding YP_001166868.1 TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; pyrimidine 5'-nucleotidase; PFAM: Haloacid dehalogenase domain protein hydrolase YP_001166869.1 PFAM: regulatory protein GntR, HTH; GntR domain protein YP_001166870.1 PFAM: glycosyl transferase, family 2; General secretory system II, protein E domain protein YP_001166871.1 PFAM: ErfK/YbiS/YcfS/YnhG family protein YP_001166872.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers YP_001166873.1 PFAM: GatB/Yqey domain protein YP_001166875.1 PFAM: cytochrome c oxidase, subunit I YP_001166876.1 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein YP_001166877.1 TIGRFAM: spermidine/putrescine ABC transporter ATPase subunit; PFAM: ABC transporter related; Transport-associated OB domain protein; SMART: AAA ATPase YP_001166879.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001166880.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001166881.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif YP_001166882.1 PFAM: protein of unknown function UPF0005 YP_001166884.1 PFAM: regulatory protein, LysR; LysR, substrate-binding YP_001166885.1 PFAM: Alcohol dehydrogenase, zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein YP_001166886.1 PFAM: helix-turn-helix domain protein YP_001166887.1 PFAM: inositol monophosphatase YP_001166888.1 biotin-containing enzyme that catalyzes a two step carboxylation of pyruvate to oxaloacetate YP_001166889.1 PFAM: UvrD/REP helicase YP_001166890.1 TIGRFAM: benzoate transporter; PFAM: Benzoate membrane transport protein YP_001166891.1 PFAM: protein of unknown function DUF1127 YP_001166893.1 MraZ; UPF0040; crystal structure shows similarity to AbrB YP_001166894.1 TIGRFAM: S-adenosyl-methyltransferase MraW; PFAM: methyltransferase YP_001166896.1 PFAM: penicillin-binding protein, transpeptidase; Penicillin-binding protein, dimerisation domain YP_001166897.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate YP_001166898.1 TIGRFAM: UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanyl ligase; PFAM: cytoplasmic peptidoglycan synthetase domain protein; Mur ligase, middle domain protein YP_001166899.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan YP_001166900.1 PFAM: transport-associated YP_001166901.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation YP_001166902.1 PFAM: glutathione-dependent formaldehyde-activating, GFA YP_001166903.1 TIGRFAM: cell division protein FtsW; PFAM: cell cycle protein YP_001166904.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis YP_001166905.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis YP_001166907.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis YP_001166908.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli YP_001166909.1 PFAM: cell division protein FtsQ; Polypeptide-transport-associated domain protein, FtsQ-type YP_001166910.1 PFAM: cell division protein FtsA YP_001166911.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function YP_001166912.1 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis YP_001166913.1 PFAM: Tetratricopeptide TPR_2 repeat protein YP_001166914.1 TIGRFAM: DNA repair protein RecN; PFAM: SMC domain protein YP_001166916.1 PFAM: FAD linked oxidase domain protein YP_001166918.1 PFAM: Methionine synthase, B12-binding module, cap domain protein; cobalamin B12-binding domain protein YP_001166919.1 PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB YP_001166920.1 catalyzes the formation of methionine from L-homocysteine and S-adenosyl-L-methionine YP_001166921.1 PFAM: protein of unknown function DUF1476 YP_001166922.1 TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase YP_001166923.1 TIGRFAM: phosphoribosylformylglycinamidine synthase, purS; PFAM: phosphoribosylformylglycinamidine synthetase PurS YP_001166924.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_001166925.1 PFAM: ATP-binding region, ATPase domain protein; histidine kinase A domain protein YP_001166926.1 PFAM: response regulator receiver; sigma-54 factor, interaction domain-containing protein; helix-turn-helix, Fis-type; ATPase associated with various cellular activities, AAA_5; SMART: AAA ATPase YP_001166927.1 TIGRFAM: ribonuclease, Rne/Rng family; PFAM: RNA binding S1 domain protein YP_001166928.1 PFAM: SirA family protein YP_001166929.1 PFAM: cytochrome c biogenesis protein, transmembrane region YP_001166932.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle YP_001166933.1 PFAM: protein of unknown function DUF1321 YP_001166934.1 PFAM: protein of unknown function DUF1194 YP_001166936.1 PFAM: phage integrase family protein YP_001166937.1 PFAM: phage integrase family protein YP_001166940.1 PFAM: transposase, IS111A/IS1328/IS1533; transposase IS116/IS110/IS902 family protein YP_001166942.1 PFAM: Integrase, catalytic region YP_001166944.1 PFAM: transposase IS66 YP_001166946.1 PFAM: transposase, IS111A/IS1328/IS1533; transposase IS116/IS110/IS902 family protein YP_001166947.1 PFAM: plasmid pRiA4b ORF-3 family protein YP_001166951.1 PFAM: Integrase, catalytic region YP_001166952.1 PFAM: transposase IS3/IS911 family protein YP_001166953.1 TIGRFAM: chromate transporter, chromate ion transporter (CHR) family; PFAM: Chromate transporter YP_001166954.1 SMART: Rhodanese domain protein YP_001166955.1 PFAM: Rhodanese domain protein YP_001166956.1 PFAM: conserved hypothetical protein 374 YP_001166958.1 PFAM: Rhodanese domain protein YP_001166959.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001166960.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001166961.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001166963.1 PFAM: Taurine catabolism dioxygenase TauD/TfdA YP_001166965.1 TIGRFAM: cysteine desulfurase, SufS subfamily; PFAM: aminotransferase, class V YP_001166968.1 PFAM: Rhodanese domain protein YP_001166969.1 PFAM: protein of unknown function DUF1234 YP_001166971.1 catalyzes the formation of acetyl phosphate and sulfite from 2-sulfoacetaldehyde; is active when grown on taurine as a sole carbon source YP_001166972.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001166973.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001166975.1 TIGRFAM: aliphatic sulfonates family ABC transporter, periplsmic ligand-binding protein; PFAM: Substrate-binding region of ABC-type glycine betaine transport system; SMART: extracellular solute-binding protein, family 3 YP_001166976.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001166977.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001166978.1 PFAM: molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; molybdopterin oxidoreductase Fe4S4 region YP_001166979.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein YP_001166980.1 PFAM: DMSO reductase anchor subunit (DmsC) YP_001166982.1 PFAM: NADPH-dependent FMN reductase YP_001166983.1 PFAM: oxidoreductase/nitrogenase, component 1 YP_001166984.1 PFAM: oxidoreductase/nitrogenase, component 1 YP_001166985.1 PFAM: NifH/frxC-family protein YP_001166986.1 PFAM: Radical SAM domain protein YP_001166987.1 TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes YP_001166988.1 TIGRFAM: aliphatic sulfonates family ABC transporter, periplsmic ligand-binding protein; PFAM: ABC transporter, substrate-binding protein, aliphatic sulphonates; SMART: extracellular solute-binding protein, family 3 YP_001166989.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001166990.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001166991.1 PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; aromatic amino acid beta-eliminating lyase/threonine aldolase YP_001166992.1 PFAM: OsmC family protein YP_001166993.1 TIGRFAM: acetate--CoA ligase; PFAM: AMP-dependent synthetase and ligase YP_001166994.1 TIGRFAM: lipoprotein, YaeC family; PFAM: NLPA lipoprotein YP_001166995.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001166996.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001166997.1 PFAM: NLPA lipoprotein YP_001166998.1 PFAM: AMP-dependent synthetase and ligase YP_001167000.1 PFAM: regulatory protein, AsnC/Lrp family YP_001167002.1 TIGRFAM: sulfate ABC transporter, ATPase subunit; PFAM: ABC transporter related; SMART: AAA ATPase YP_001167003.1 TIGRFAM: sulfate ABC transporter, inner membrane subunit; sulfate ABC transporter, inner membrane subunit CysW; PFAM: binding-protein-dependent transport systems inner membrane component YP_001167004.1 TIGRFAM: sulfate ABC transporter, inner membrane subunit; sulfate ABC transporter, inner membrane subunit CysT; PFAM: binding-protein-dependent transport systems inner membrane component YP_001167005.1 TIGRFAM: sulfate ABC transporter, periplasmic sulfate-binding protein; PFAM: extracellular solute-binding protein, family 1 YP_001167007.1 TIGRFAM: putative transcriptional regulator, Rrf2 family; PFAM: protein of unknown function UPF0074 YP_001167008.1 PFAM: transposase IS3/IS911 family protein YP_001167010.1 PFAM: transposase, IS4 family protein YP_001167011.1 PFAM: IstB domain protein ATP-binding protein YP_001167012.1 PFAM: IstB domain protein ATP-binding protein YP_001167013.1 PFAM: transposase, IS111A/IS1328/IS1533; transposase IS116/IS110/IS902 family protein YP_001167014.1 PFAM: transposase, IS111A/IS1328/IS1533; transposase IS116/IS110/IS902 family protein YP_001167015.1 PFAM: transposase IS116/IS110/IS902 family protein YP_001167019.1 PFAM: peptidase M41; AAA ATPase, central domain protein; SMART: AAA ATPase YP_001167021.1 PFAM: helix-turn-helix domain protein YP_001167023.1 PFAM: aminotransferase, class V YP_001167024.1 PFAM: DNA photolyase, FAD-binding; DNA photolyase domain protein YP_001167025.1 PFAM: Cyclopropane-fatty-acyl-phospholipid synthase; Methyltransferase type 11; Methyltransferase type 12 YP_001167027.1 PFAM: NUDIX hydrolase YP_001167028.1 CysK; forms a complex with serine acetyltransferase CysE; functions in cysteine biosynthesis YP_001167029.1 PFAM: MscS Mechanosensitive ion channel YP_001167030.1 PFAM: Threonyl/alanyl tRNA synthetase, SAD YP_001167032.1 PFAM: metallophosphoesterase YP_001167033.1 PFAM: phosphoesterase, PA-phosphatase related YP_001167035.1 PFAM: phage integrase family protein YP_001167038.1 PFAM: transposase, IS4 family protein YP_001167040.1 PFAM: phage integrase family protein YP_001167041.1 TIGRFAM: single-stranded-DNA-specific exonuclease RecJ; PFAM: phosphoesterase, RecJ domain protein; phosphoesterase, DHHA1 YP_001167042.1 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese YP_001167043.1 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine YP_001167044.1 PFAM: regulatory protein, TetR YP_001167048.1 PFAM: Glu/Leu/Phe/Val dehydrogenase, C terminal; Glu/Leu/Phe/Val dehydrogenase, dimerisation region YP_001167049.1 synthesizes RNA primers at the replication forks YP_001167050.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria YP_001167052.1 PFAM: ATP-cone domain protein YP_001167053.1 TIGRFAM: riboflavin biosynthesis protein RibD; PFAM: CMP/dCMP deaminase, zinc-binding; bifunctional deaminase-reductase domain protein YP_001167054.1 PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase YP_001167055.1 PFAM: thymidylate synthase YP_001167056.1 PFAM: dihydrofolate reductase region YP_001167058.1 PFAM: arsenate reductase and related YP_001167059.1 PFAM: Cold-shock protein, DNA-binding; SMART: Cold shock protein YP_001167060.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr) YP_001167062.1 TIGRFAM: polyhydroxyalkanoate depolymerase, intracellular; PFAM: PHB de-polymerase domain protein YP_001167063.1 TIGRFAM: poly(R)-hydroxyalkanoic acid synthase, class I; PFAM: Poly-beta-hydroxybutyrate polymerase domain protein YP_001167065.1 TIGRFAM: polyhydroxyalkanoate synthesis repressor PhaR; PFAM: PHB accumulation regulatory domain protein; PHA accumulation regulator DNA-binding protein YP_001167066.1 PFAM: aminotransferase class-III YP_001167069.1 PFAM: transposase, IS4 family protein YP_001167071.1 PFAM: FAD dependent oxidoreductase YP_001167072.1 PFAM: glutamine synthetase, catalytic region YP_001167073.1 PFAM: glutamine amidotransferase class-I YP_001167074.1 PFAM: glutamine synthetase, catalytic region YP_001167075.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001167076.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001167077.1 PFAM: extracellular solute-binding protein, family 3 YP_001167078.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001167079.1 PFAM: protein of unknown function DUF1332 YP_001167080.1 PFAM: protein of unknown function DUF519 YP_001167081.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer YP_001167082.1 TIGRFAM: preprotein translocase, SecG subunit; PFAM: Preprotein translocase SecG subunit YP_001167083.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis YP_001167085.1 PFAM: transposase, IS4 family protein YP_001167087.1 TIGRFAM: thiamine pyrophosphokinase; PFAM: Thiamin pyrophosphokinase, catalytic region YP_001167088.1 PFAM: protein of unknown function DUF6, transmembrane YP_001167089.1 TIGRFAM: L-serine dehydratase 1; PFAM: serine dehydratase alpha chain; serine dehydratase beta chain YP_001167091.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway YP_001167092.1 TIGRFAM: glutathione-disulfide reductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region YP_001167093.1 TIGRFAM: HflK protein; PFAM: band 7 protein YP_001167094.1 TIGRFAM: HflC protein; PFAM: band 7 protein YP_001167095.1 TIGRFAM: protease Do; PFAM: peptidase S1 and S6, chymotrypsin/Hap; PDZ/DHR/GLGF domain protein YP_001167097.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase YP_001167099.1 PFAM: protein of unknown function DUF710 YP_001167100.1 TIGRFAM: glutaredoxin-like protein; PFAM: glutaredoxin YP_001167101.1 PFAM: BolA family protein YP_001167102.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_001167103.1 PFAM: regulatory protein, LysR; LysR, substrate-binding YP_001167104.1 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates YP_001167105.1 TIGRFAM: glutamate racemase; PFAM: Asp/Glu racemase YP_001167106.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate YP_001167107.1 CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane YP_001167108.1 PFAM: protein of unknown function DUF847 YP_001167110.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase YP_001167111.1 PFAM: Sporulation domain protein YP_001167112.1 PFAM: glycoside hydrolase, family 3 domain protein YP_001167113.1 PFAM: chromosome segregation and condensation protein ScpA YP_001167114.1 TIGRFAM: segregation and condensation protein B; PFAM: chromosome segregation and condensation protein ScpB YP_001167116.1 PFAM: protein of unknown function DUF1045 YP_001167117.1 PFAM: Disulphide bond formation protein DsbB YP_001167118.1 PFAM: protein of unknown function, zinc metallopeptidase putative YP_001167123.1 PFAM: transposase IS66 YP_001167124.1 PFAM: IS66 Orf2 family protein YP_001167125.1 PFAM: transposase IS3/IS911 family protein YP_001167129.1 PFAM: inner-membrane translocator YP_001167130.1 PFAM: inner-membrane translocator YP_001167131.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001167132.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001167133.1 PFAM: Extracellular ligand-binding receptor YP_001167134.1 TIGRFAM: tyrosyl-tRNA synthetase; PFAM: aminoacyl-tRNA synthetase, class Ib YP_001167135.1 catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling YP_001167137.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis YP_001167138.1 PFAM: protein of unknown function DUF6, transmembrane YP_001167139.1 PFAM: ferric-uptake regulator YP_001167140.1 Catalyzes the rate-limiting step in dNTP synthesis YP_001167141.1 PFAM: cell wall hydrolase, SleB YP_001167142.1 PFAM: transposase IS3/IS911 family protein YP_001167143.1 PFAM: IS66 Orf2 family protein YP_001167144.1 PFAM: transposase, IS4 family protein YP_001167148.1 PFAM: IstB domain protein ATP-binding protein; SMART: AAA ATPase YP_001167149.1 PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type YP_001167150.1 PFAM: ferredoxin YP_001167151.1 PFAM: aldo/keto reductase YP_001167153.1 PFAM: ABC transporter related; Transport-associated OB domain protein; SMART: AAA ATPase YP_001167154.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001167155.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001167156.1 PFAM: extracellular solute-binding protein, family 1 YP_001167157.1 PFAM: basic membrane lipoprotein YP_001167158.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001167159.1 PFAM: inner-membrane translocator YP_001167160.1 PFAM: inner-membrane translocator YP_001167161.1 Catalyzes the deamination of cytosine to uracil and ammonia YP_001167162.1 PFAM: protein of unknown function UPF0118 YP_001167163.1 PFAM: Methyltransferase type 11; Methyltransferase type 12 YP_001167164.1 PFAM: diacylglycerol kinase, catalytic region YP_001167165.1 PFAM: metallophosphoesterase YP_001167166.1 TIGRFAM: PAS sensor protein; diguanylate cyclase; PFAM: GGDEF domain containing protein; EAL domain protein; PAS fold-4 domain protein YP_001167168.1 PFAM: glycosyl transferase, family 2; type IV pilus assembly PilZ YP_001167170.1 PFAM: glycoside hydrolase, family 8 YP_001167172.1 TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; GAF domain protein YP_001167173.1 PFAM: NnrS family protein YP_001167174.1 PFAM: cyclic nucleotide-binding; regulatory protein, Crp YP_001167177.1 PFAM: cytochrome c oxidase, subunit I YP_001167178.1 PFAM: ATPase associated with various cellular activities, AAA_5; CbbQ/NirQ/NorQ C-terminal domain protein YP_001167179.1 PFAM: von Willebrand factor, type A YP_001167182.1 PFAM: NnrU family protein YP_001167183.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_001167184.1 PFAM: regulatory protein, LuxR YP_001167185.1 PFAM: PUCC protein; major facilitator superfamily MFS_1 YP_001167186.1 PFAM: antenna complex, alpha/beta subunit YP_001167187.1 PFAM: antenna complex, alpha/beta subunit YP_001167188.1 PFAM: aminotransferase class-III YP_001167189.1 PFAM: aminoglycoside phosphotransferase YP_001167190.1 PFAM: Urease accessory protein UreD YP_001167191.1 UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter YP_001167192.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori and Yersinia enterocolitica the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 UreC (alpha) and 3 UreAB (gamma/beta); in Brucella suis the urease encoded by this operon (one of two urease-encoding operons found in its genome) is involved with urease activity, optimum growth, resistance to low-pH killing in-vitro and persistence in-vivo, while the other operon does not seem to be active YP_001167194.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits YP_001167196.1 involved in the assembly of the urease metallocenter; possible nickel donor YP_001167197.1 PFAM: Urease accessory protein UreF YP_001167198.1 TIGRFAM: urease accessory protein UreG; PFAM: cobalamin synthesis protein, P47K YP_001167200.1 PFAM: inner-membrane translocator YP_001167201.1 PFAM: inner-membrane translocator YP_001167202.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001167203.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001167204.1 PFAM: cytochrome c, class I YP_001167206.1 oxidative; catalyzes the formation of divinylprotochlorophyllide from magnesium-protoporphyrin IX 13-monomethyl ester in isocyclic ring formation in chlorophyll biosynthesis YP_001167210.1 TIGRFAM: photosynthetic reaction center H subunit; PFAM: photosynthetic reaction centre, H-chain; PRC-barrel domain protein YP_001167211.1 PFAM: PUCC protein; major facilitator superfamily MFS_1 YP_001167212.1 catalyzes the formation of Mg-protoporphyrin IX methyl ester and S-adenosyl-L-homocysteine from Mg-protoporphyrin IX and S-adenosyl-L-methionine YP_001167213.1 light-independent; with chlN(bchN) and chlB(bchB) reduces ring D of protochlorophyllide to form chlorophyllide a in chlorophyll/bacteriochlorophyll production YP_001167214.1 involved in chelation of magnesium into protoporphyrin IX; involved in bacteriochlorophyll biosynthesis; the enzyme from Rhodobacter capsulatus contains an Fe-S cluster; part of a complex with BchI, BchD, and BchH YP_001167215.1 light-independent reduction of protochlorophyllide to form chlorophyllide a YP_001167216.1 light-independent reduction of protochlorophyllide to form chlorophyllide a YP_001167217.1 PFAM: 2-vinyl bacteriochlorophyllide hydratase YP_001167219.1 TIGRFAM: PAS sensor protein; transcriptional regulator PpsR; PFAM: helix-turn-helix, Fis-type; SMART: PAS domain containing protein YP_001167220.1 TIGRFAM: magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; PFAM: cobalamin B12-binding domain protein; Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB YP_001167221.1 TIGRFAM: bacteriochlorophyll 4-vinyl reductase; PFAM: 4-vinyl reductase, 4VR YP_001167222.1 TIGRFAM: bacteriochlorophyll/chlorophyll synthetase; PFAM: UbiA prenyltransferase YP_001167223.1 PFAM: PUCC protein; major facilitator superfamily MFS_1 YP_001167224.1 TIGRFAM: geranylgeranyl reductase; PFAM: monooxygenase, FAD-binding; Lycopene beta and epsilon cyclase YP_001167225.1 TIGRFAM: isopentenyl-diphosphate delta-isomerase, type 1; PFAM: NUDIX hydrolase YP_001167226.1 PFAM: alpha/beta hydrolase fold YP_001167227.1 involved in chelation of magnesium into protoporphyrin IX; involved in bacteriochlorophyll biosynthesis; part of a complex with BchI, BchD, and BchH YP_001167228.1 involved in chelation of magnesium into protoporphyrin IX; involved in bacteriochlorophyll biosynthesis; part of a complex with BchI, BchD, and BchH YP_001167230.1 TIGRFAM: Phytoene dehydrogenase-related protein; PFAM: amine oxidase; FAD dependent oxidoreductase YP_001167231.1 PFAM: Squalene/phytoene synthase YP_001167232.1 PFAM: TspO/MBR family protein YP_001167233.1 PFAM: ferredoxin YP_001167234.1 catalyzes the transfer of the N5-methyl group from (6S)-methyl tetrahydrofolate to the cobalt center of a corrinoid iron-sulfur protein YP_001167237.1 PFAM: Ppx/GppA phosphatase YP_001167240.1 PFAM: protein of unknown function DUF882; Peptidase M15A YP_001167241.1 PFAM: Peptidoglycan-binding domain 1 protein YP_001167242.1 TIGRFAM: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase YP_001167243.1 PFAM: phosphopantetheine-binding YP_001167244.1 PFAM: beta-ketoacyl synthase YP_001167245.1 PFAM: Invasion associated locus B family protein YP_001167246.1 TIGRFAM: MIP family channel protein; PFAM: major intrinsic protein YP_001167247.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group YP_001167249.1 PFAM: cytochrome c, class II YP_001167250.1 TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase YP_001167251.1 PFAM: cyclase/dehydrase YP_001167252.1 PFAM: histidine kinase, HAMP region domain protein; chemotaxis sensory transducer YP_001167253.1 catalyzes the methylthiolation of an aspartic acid residue of the S12 protein of the 30S ribosomal subunit YP_001167254.1 PFAM: aminotransferase, class I and II YP_001167255.1 catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively YP_001167256.1 PFAM: Lysine exporter protein (LYSE/YGGA) YP_001167257.1 Catalyzes a key regulatory step in fatty acid biosynthesis YP_001167258.1 TIGRFAM: pyridoxamine 5'-phosphate oxidase; PFAM: pyridoxamine 5'-phosphate oxidase-related, FMN-binding YP_001167259.1 PFAM: Cold-shock protein, DNA-binding; SMART: Cold shock protein YP_001167260.1 PFAM: protein of unknown function DUF192 YP_001167261.1 TIGRFAM: cobalamin 5'-phosphate synthase; PFAM: cobalamin-5-phosphate synthase CobS YP_001167262.1 catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole YP_001167263.1 PFAM: TrkA-N domain protein; sodium/hydrogen exchanger YP_001167265.1 PFAM: protein of unknown function DUF541 YP_001167266.1 TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; DegT/DnrJ/EryC1/StrS aminotransferase; aromatic amino acid beta-eliminating lyase/threonine aldolase YP_001167267.1 PFAM: short-chain dehydrogenase/reductase SDR; KR YP_001167268.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway YP_001167269.1 PFAM: Colicin V production protein YP_001167270.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents YP_001167271.1 PFAM: Paraquat-inducible protein A YP_001167272.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001167273.1 PFAM: protein of unknown function DUF140 YP_001167274.1 TIGRFAM: alanine racemase; PFAM: alanine racemase domain protein YP_001167275.1 TIGRFAM: 3-oxoacyl-(acyl-carrier-protein) reductase; PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; KR YP_001167276.1 carries the fatty acid chain in fatty acid biosynthesis YP_001167277.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP YP_001167278.1 PFAM: aminodeoxychorismate lyase YP_001167280.1 PFAM: protein of unknown function DUF264 YP_001167281.1 TIGRFAM: phage portal protein, HK97 family; PFAM: phage portal protein YP_001167283.1 TIGRFAM: phage prohead protease, HK97 family; PFAM: peptidase U35, phage prohead HK97 YP_001167284.1 TIGRFAM: phage major capsid protein, HK97 family; PFAM: phage major capsid protein, HK97 YP_001167286.1 TIGRFAM: phage head-tail adaptor, putative YP_001167288.1 TIGRFAM: phage major tail protein, TP901-1 family YP_001167294.1 TIGRFAM: putative phage cell wall peptidase, NlpC/P60 family; PFAM: NLP/P60 protein YP_001167297.1 TIGRFAM: serine O-acetyltransferase; PFAM: transferase hexapeptide repeat containing protein; serine acetyltransferase domain protein YP_001167298.1 TIGRFAM: pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; PFAM: biotin/lipoyl attachment domain-containing protein; catalytic domain of components of various dehydrogenase complexes; E3 binding domain protein YP_001167299.1 catalyzes the oxidative decarboxylation of pyruvate with concomitant acetylation of a lipoic acid-containing dihydrolipoamide acetyltransferase within the complex. The E1 component of the pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase(E2) and lipoamide dehydrogenase YP_001167300.1 PFAM: dehydrogenase, E1 component YP_001167301.1 PFAM: Septum formation initiator YP_001167302.1 catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate YP_001167303.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway YP_001167304.1 PFAM: peptidyl-prolyl cis-trans isomerase, cyclophilin type YP_001167305.1 PFAM: peptidyl-prolyl cis-trans isomerase, cyclophilin type YP_001167306.1 PFAM: helix-turn-helix- domain containing protein, AraC type; ThiJ/PfpI domain protein YP_001167307.1 TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase, class II YP_001167308.1 PFAM: protein of unknown function DUF1457 YP_001167309.1 PFAM: YicC N-terminal domain protein; domain of unknown function DUF1732 YP_001167310.1 Essential for recycling GMP and indirectly, cGMP YP_001167312.1 PFAM: ATP-binding region, ATPase domain protein; histidine kinase A domain protein; PAS fold-4 domain protein YP_001167313.1 PFAM: Inosine/uridine-preferring nucleoside hydrolase YP_001167314.1 PFAM: extracellular solute-binding protein, family 1 YP_001167315.1 functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era YP_001167316.1 TIGRFAM: amidohydrolase; PFAM: peptidase M20; peptidase dimerisation domain protein YP_001167317.1 catalyzes the formation of putrescine from agmatine YP_001167319.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 YP_001167320.1 TIGRFAM: modification methylase, HemK family; PFAM: methyltransferase small; Methyltransferase type 12 YP_001167322.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin YP_001167323.1 catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate) YP_001167324.1 PFAM: PpiC-type peptidyl-prolyl cis-trans isomerase YP_001167325.1 PFAM: OstA family protein; Organic solvent tolerance protein YP_001167326.1 PFAM: permease YjgP/YjgQ family protein YP_001167327.1 PFAM: permease YjgP/YjgQ family protein YP_001167328.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides YP_001167329.1 binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB YP_001167331.1 PFAM: multiple antibiotic resistance (MarC)-related protein YP_001167332.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001167333.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate YP_001167335.1 TIGRFAM: ATPase, P-type (transporting), HAD superfamily, subfamily IC; copper-translocating P-type ATPase; heavy metal translocating P-type ATPase; PFAM: Haloacid dehalogenase domain protein hydrolase; Heavy metal transport/detoxification protein; E1-E2 ATPase-associated domain protein YP_001167336.1 TIGRFAM: Cu(I)-responsive transcriptional regulator; PFAM: regulatory protein, MerR YP_001167337.1 TIGRFAM: putative transcriptional regulator, Rrf2 family; PFAM: protein of unknown function UPF0074 YP_001167338.1 TIGRFAM: glycogen/starch/alpha-glucan phosphorylase; PFAM: glycosyl transferase, family 35 YP_001167339.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain YP_001167340.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate YP_001167341.1 catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose YP_001167342.1 TIGRFAM: glycogen debranching enzyme GlgX; PFAM: glycoside hydrolase, family 13 domain protein; alpha amylase, catalytic region; SMART: alpha amylase, catalytic sub domain YP_001167343.1 catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate YP_001167344.1 PFAM: regulatory protein, LuxR; response regulator receiver YP_001167345.1 PFAM: domain of unknown function DUF1745 YP_001167346.1 PFAM: response regulator receiver; ATP-binding region, ATPase domain protein; histidine kinase A domain protein; PAS fold-4 domain protein YP_001167347.1 PFAM: cyclase/dehydrase; carbon monoxide dehydrogenase subunit G YP_001167348.1 PFAM: ferredoxin; [2Fe-2S]-binding domain protein YP_001167349.1 PFAM: aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead; aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding YP_001167350.1 PFAM: molybdopterin dehydrogenase, FAD-binding YP_001167351.1 PFAM: Glucokinase YP_001167352.1 PFAM: glycoside hydrolase, family 1 YP_001167353.1 PFAM: extracellular solute-binding protein, family 1 YP_001167354.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001167355.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001167356.1 PFAM: ABC transporter related; TOBE domain protein; Transport-associated OB domain protein; SMART: AAA ATPase YP_001167358.1 TIGRFAM: inosine-5'-monophosphate dehydrogenase; PFAM: CBS domain containing protein; IMP dehydrogenase/GMP reductase YP_001167359.1 PFAM: regulatory protein, TetR YP_001167360.1 TIGRFAM: efflux transporter, RND family, MFP subunit; PFAM: secretion protein HlyD family protein YP_001167361.1 PFAM: acriflavin resistance protein YP_001167362.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr) YP_001167363.1 PFAM: NADH:flavin oxidoreductase/NADH oxidase YP_001167364.1 TIGRFAM: ATP-dependent protease La; PFAM: peptidase S16, lon domain protein; AAA ATPase, central domain protein; ATPase associated with various cellular activities, AAA_5; SMART: AAA ATPase YP_001167365.1 TIGRFAM: DNA ligase, NAD-dependent; PFAM: BRCT domain protein; zinc-finger, NAD-dependent DNA ligase C4-type; NAD-dependent DNA ligase, OB-fold; NAD-dependent DNA ligase, adenylation; SMART: NAD-dependent DNA ligase-like YP_001167366.1 catalyzes branch migration in Holliday junction intermediates YP_001167369.1 PFAM: phosphoribosyl-AMP cyclohydrolase YP_001167370.1 PFAM: glutamyl-tRNA synthetase, class Ic YP_001167371.1 TrmFO; Gid; glucose-inhibited division protein; similar to GidA; the gene from Bacillus subtilis encodes a tRNA-methyltransferase that utilizes folate as the carbon donor and bound flavin as reductant; modifies tRNA at position 54 (uridine) of the T-psi loop to form a C5-methyluridine YP_001167372.1 negatively supercoils closed circular double-stranded DNA YP_001167373.1 PFAM: Usg family protein YP_001167374.1 TIGRFAM: arginase; PFAM: Arginase/agmatinase/formiminoglutamase YP_001167375.1 TIGRFAM: cytochrome c-type biogenesis protein CcmF; PFAM: cytochrome c assembly protein YP_001167376.1 PFAM: cytochrome C biogenesis protein YP_001167377.1 PFAM: Enoyl-CoA hydratase/isomerase YP_001167378.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit YP_001167379.1 TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein YP_001167380.1 TIGRFAM: Na+/Ca+ antiporter, CaCA family; PFAM: sodium/calcium exchanger membrane region YP_001167381.1 Conjugates Arg from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate YP_001167382.1 PFAM: RDD domain containing protein YP_001167384.1 PFAM: glutamate-ammonia ligase adenylyltransferase YP_001167386.1 TIGRFAM: 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase; PFAM: KDPG and KHG aldolase YP_001167387.1 catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate YP_001167389.1 PFAM: putative RNA methylase YP_001167391.1 PFAM: peptidase M48, Ste24p YP_001167396.1 PFAM: GCN5-related N-acetyltransferase YP_001167397.1 PFAM: ATPase associated with various cellular activities, AAA_5; SMART: AAA ATPase YP_001167398.1 TIGRFAM: RNA polymerase-binding protein DksA; PFAM: zinc finger, DksA/TraR C4-type YP_001167399.1 PFAM: monooxygenase, FAD-binding; FAD dependent oxidoreductase YP_001167400.1 PFAM: thioesterase superfamily protein YP_001167401.1 TIGRFAM: exodeoxyribonuclease III; exodeoxyribonuclease III Xth; PFAM: Endonuclease/exonuclease/phosphatase YP_001167402.1 TIGRFAM: iron-sulfur cluster assembly accessory protein; PFAM: HesB/YadR/YfhF-family protein YP_001167403.1 TIGRFAM: putative deoxyguanosinetriphosphate triphosphohydrolase; PFAM: metal-dependent phosphohydrolase, HD sub domain; SMART: metal-dependent phosphohydrolase, HD region YP_001167404.1 TIGRFAM: putative ribonuclease BN; PFAM: ribonuclease BN YP_001167405.1 PFAM: iron-containing alcohol dehydrogenase YP_001167406.1 TIGRFAM: glycerol kinase; PFAM: carbohydrate kinase, FGGY YP_001167407.1 PFAM: extracellular solute-binding protein, family 1 YP_001167410.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001167411.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001167412.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001167413.1 PFAM: ABC transporter related; Transport-associated OB domain protein YP_001167414.1 in Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane YP_001167417.1 PFAM: Pyrrolo-quinoline quinone YP_001167418.1 PFAM: PRC-barrel domain protein YP_001167420.1 PFAM: transport-associated; SMART: Transport-associated and nodulation region, bacteria YP_001167421.1 PFAM: response regulator receiver YP_001167422.1 PFAM: MgtC/SapB transporter YP_001167424.1 PFAM: DNA primase, small subunit; ATP dependent DNA ligase domain protein; ATP dependent DNA ligase YP_001167426.1 PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70, region 4 type 2 YP_001167427.1 TIGRFAM: malonyl CoA-acyl carrier protein transacylase; PFAM: acyl transferase domain protein YP_001167428.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs YP_001167430.1 similar to novel fructose-6-phosphate aldolase from Escherichia coli; enzyme from Methanocaldococcus janaschii shows transaldolase activity YP_001167431.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity YP_001167432.1 TIGRFAM: peptide methionine sulfoxide reductase; PFAM: Methionine sulfoxide reductase A YP_001167433.1 PFAM: ribosomal L11 methyltransferase YP_001167435.1 PFAM: protein of unknown function DUF1127 YP_001167436.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity YP_001167437.1 plays an essential role in ATP-dependent branch migration of the Holliday junction YP_001167438.1 putative metalloprotease YP_001167439.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration YP_001167440.1 PFAM: small multidrug resistance protein YP_001167442.1 PFAM: thymidylate kinase YP_001167443.1 PFAM: peptidase S11, D-alanyl-D-alanine carboxypeptidase 1; Penicillin-binding protein 5 domain protein YP_001167444.1 PFAM: Sporulation domain protein YP_001167445.1 PFAM: Rhodanese domain protein YP_001167446.1 TIGRFAM: Nif-specific regulatory protein; PFAM: sigma-54 factor, interaction domain-containing protein; helix-turn-helix, Fis-type; ATPase associated with various cellular activities, AAA_5; SMART: GAF domain protein; AAA ATPase YP_001167447.1 TIGRFAM: nitrogenase cofactor biosynthesis protein NifB; PFAM: Dinitrogenase iron-molybdenum cofactor biosynthesis protein; Radical SAM domain protein YP_001167448.1 PFAM: leucine rich repeat variant; LRV FeS4 cluster domain protein YP_001167449.1 PFAM: NifZ family protein YP_001167450.1 PFAM: NifT/FixU family protein YP_001167452.1 nitrogenase iron protein; nitrogenase component 2; with component 1, an molybdenum-iron protein, catalyzes the fixation of nitrogen to ammonia; nitrogen reductase provides electrons to the nitrogenase complex; in R. etli there are three essentially identical copies of nifH which are actively expressed during symbiosis YP_001167453.1 TIGRFAM: nitrogenase molybdenum-iron protein alpha chain; nitrogenase component I, alpha chain; PFAM: oxidoreductase/nitrogenase, component 1 YP_001167454.1 TIGRFAM: nitrogenase molybdenum-iron protein beta chain; PFAM: oxidoreductase/nitrogenase, component 1 YP_001167455.1 TIGRFAM: nitrogenase MoFe cofactor biosynthesis protein NifE; PFAM: oxidoreductase/nitrogenase, component 1 YP_001167456.1 functions with NifE to assemble FeMo cofactor; functions in assembly of nitrogenase MoFe YP_001167457.1 TIGRFAM: nitrogen fixation protein NifX; PFAM: Dinitrogenase iron-molybdenum cofactor biosynthesis protein YP_001167458.1 PFAM: protein of unknown function DUF269 YP_001167459.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein YP_001167460.1 PFAM: NifQ family protein YP_001167461.1 TIGRFAM: iron-sulfur cluster assembly accessory protein; PFAM: HesB/YadR/YfhF-family protein YP_001167462.1 PFAM: nitrogen-fixing NifU domain protein YP_001167463.1 PFAM: aminotransferase, class V; aromatic amino acid beta-eliminating lyase/threonine aldolase YP_001167464.1 TIGRFAM: homocitrate synthase; PFAM: pyruvate carboxyltransferase YP_001167465.1 associates with NifD and may protect the nitrogenase Fe-Mo protein from oxidative damage YP_001167466.1 TIGRFAM: RNA polymerase sigma-54 factor, RpoN; PFAM: sigma-54 factor; sigma-54 factor, core-binding region; sigma-54, DNA-binding domain protein YP_001167468.1 PFAM: Hly-III family protein YP_001167469.1 PFAM: Ku domain protein YP_001167478.1 PFAM: peptidase S24, S26A and S26B YP_001167480.1 PFAM: histone family protein DNA-binding protein YP_001167484.1 PFAM: ParB domain protein nuclease YP_001167485.1 PFAM: Integrase, catalytic region YP_001167489.1 PFAM: Chromosomal replication initiator, DnaA C-terminal domain YP_001167492.1 PFAM: protein of unknown function DUF1018 YP_001167494.1 PFAM: MT-A70 family protein YP_001167497.1 PFAM: N-acetylmuramoyl-L-alanine amidase, family 2; SH3, type 3 domain protein; SMART: SH3 domain protein YP_001167503.1 PFAM: protein of unknown function DUF264 YP_001167505.1 PFAM: protein of unknown function DUF935 YP_001167506.1 PFAM: phage putative head morphogenesis protein, SPP1 gp7 YP_001167507.1 TIGRFAM: phage virion morphogenesis protein YP_001167512.1 PFAM: protein of unknown function DUF1320 YP_001167527.1 PFAM: RNA-directed DNA polymerase (Reverse transcriptase) YP_001167529.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate YP_001167530.1 TIGRFAM: export-related chaperone CsaA; PFAM: t-RNA-binding domain protein YP_001167531.1 PFAM: 6-phosphogluconate dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding YP_001167532.1 PFAM: transposase, IS4 family protein YP_001167535.1 PFAM: NAD-dependent epimerase/dehydratase; 3-beta hydroxysteroid dehydrogenase/isomerase; dTDP-4-dehydrorhamnose reductase YP_001167536.1 TIGRFAM: UDP-glucose 4-epimerase; PFAM: NAD-dependent epimerase/dehydratase; 3-beta hydroxysteroid dehydrogenase/isomerase; polysaccharide biosynthesis protein CapD; dTDP-4-dehydrorhamnose reductase; Male sterility C-terminal domain YP_001167539.1 PFAM: acyl-CoA dehydrogenase domain protein; Acyl-CoA dehydrogenase, type 2, C-terminal domain YP_001167540.1 PFAM: Enoyl-CoA hydratase/isomerase YP_001167541.1 TIGRFAM: 3-hydroxyisobutyrate dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase; NADP oxidoreductase, coenzyme F420-dependent; 6-phosphogluconate dehydrogenase, NAD-binding YP_001167544.1 PFAM: ATPase associated with various cellular activities, AAA_3; SMART: AAA ATPase YP_001167545.1 PFAM: ATP-binding region, ATPase domain protein; histidine kinase A domain protein; CHASE3 domain protein YP_001167546.1 PFAM: response regulator receiver YP_001167547.1 PFAM: response regulator receiver; ATP-binding region, ATPase domain protein; histidine kinase, dimerisation/phosphoacceptor YP_001167548.1 TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase, catalytic region; glutamine synthetase, beta-Grasp YP_001167549.1 PFAM: nitrogen regulatory protein P-II YP_001167551.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer YP_001167552.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk YP_001167553.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit YP_001167554.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 YP_001167556.1 TIGRFAM: phage/plasmid primase, P4 family; PFAM: Helicase superfamily 3 YP_001167558.1 TIGRFAM: phage portal protein, HK97 family; PFAM: phage portal protein YP_001167560.1 TIGRFAM: phage prohead protease, HK97 family; PFAM: peptidase U35, phage prohead HK97 YP_001167561.1 TIGRFAM: phage major capsid protein, HK97 family; PFAM: phage major capsid protein, HK97 YP_001167564.1 PFAM: HNH endonuclease; SMART: HNH nuclease YP_001167568.1 TIGRFAM: phage protein, HK97 gp10 family; PFAM: TP901-1 ORF40 family protein YP_001167570.1 PFAM: phage head-tail adaptor, putative YP_001167571.1 TIGRFAM: phage terminase, small subunit, putative, P27 family; PFAM: phage terminase, small subunit, putative, P27 YP_001167572.1 PFAM: phage Terminase YP_001167575.1 PFAM: helix-turn-helix domain protein YP_001167577.1 PFAM: phage integrase family protein YP_001167578.1 PFAM: Three-deoxy-D-manno-octulosonic-acid transferase domain protein YP_001167579.1 PFAM: Di-haem cytochrome c peroxidase YP_001167580.1 PFAM: extracellular solute-binding protein, family 1 YP_001167581.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001167582.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001167583.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001167584.1 PFAM: TonB-dependent receptor; TonB-dependent receptor, plug YP_001167585.1 PFAM: periplasmic binding protein YP_001167586.1 PFAM: transport system permease protein YP_001167587.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001167588.1 PFAM: protein of unknown function DUF105 YP_001167589.1 TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: glyceraldehyde 3-phosphate dehydrogenase YP_001167590.1 PFAM: protein of unknown function DUF808 YP_001167591.1 TIGRFAM: methylmalonate-semialdehyde dehydrogenase; PFAM: aldehyde dehydrogenase YP_001167592.1 PFAM: regulatory protein, LysR; LysR, substrate-binding YP_001167593.1 PFAM: CBS domain containing protein YP_001167594.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA YP_001167596.1 PFAM: MotA/TolQ/ExbB proton channel YP_001167597.1 PFAM: OmpA/MotB domain protein YP_001167599.1 PFAM: Hemolysin-type calcium-binding region; Peptidase M10, serralysin-like; SMART: peptidase, metallopeptidase YP_001167600.1 PFAM: Haemin-degrading family protein YP_001167602.1 PFAM: YceI family protein; cytochrome B561 YP_001167603.1 PFAM: YceI family protein YP_001167604.1 PFAM: major facilitator superfamily MFS_1 YP_001167605.1 PFAM: NADPH-dependent FMN reductase YP_001167606.1 TIGRFAM: arsenical-resistance protein; PFAM: Bile acid:sodium symporter YP_001167607.1 PFAM: GCN5-related N-acetyltransferase YP_001167608.1 PFAM: regulatory protein, ArsR YP_001167609.1 PFAM: regulatory protein, ArsR YP_001167610.1 PFAM: permease YP_001167612.1 PFAM: low molecular weight phosphotyrosine protein phosphatase; regulatory protein, ArsR YP_001167613.1 TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: glyceraldehyde 3-phosphate dehydrogenase YP_001167614.1 PFAM: major facilitator superfamily MFS_1 YP_001167615.1 PFAM: Integrase, catalytic region; transposase IS3/IS911 family protein YP_001167617.1 PFAM: transposase IS3/IS911 family protein YP_001167618.1 PFAM: IS66 Orf2 family protein YP_001167619.1 PFAM: transposase IS3/IS911 family protein YP_001167620.1 PFAM: IS66 Orf2 family protein YP_001167621.1 PFAM: transposase IS66 YP_001167623.1 PFAM: peptidase M41; AAA ATPase, central domain protein; SMART: AAA ATPase YP_001167631.1 PFAM: transposase, IS4 family protein YP_001167632.1 PFAM: transposase, IS111A/IS1328/IS1533 YP_001167633.1 PFAM: Integrase, catalytic region YP_001167634.1 PFAM: transposase, IS4 family protein YP_001167640.1 PFAM: beta-lactamase domain protein YP_001167641.1 PFAM: ATP-binding region, ATPase domain protein; histidine kinase, HAMP region domain protein; histidine kinase A domain protein YP_001167642.1 PFAM: Allergen V5/Tpx-1 family protein YP_001167643.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001167646.1 PFAM: CDP-alcohol phosphatidyltransferase YP_001167647.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates YP_001167648.1 binds and unfolds substrates as part of the ClpXP protease YP_001167649.1 Provides the input to the respiratory chain from the NAD-linked dehydrogenases of the citric acid cycle. The complex couples the oxidation of NADH and the reduction of ubiquinone, to the generation of a proton gradient which is then used for ATP synthesis YP_001167650.1 PFAM: Mammalian cell entry related domain protein YP_001167652.1 leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys YP_001167653.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism YP_001167654.1 TIGRFAM: acetyl-CoA carboxylase, biotin carboxyl carrier protein; PFAM: biotin/lipoyl attachment domain-containing protein YP_001167655.1 function undetermined; similar to glutamate synthase beta subunit and related oxidoreductases which transfer electrons from NADPH to an acceptor protein or protein domain YP_001167657.1 catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines YP_001167658.1 PFAM: regulatory protein, TetR; Tetracycline transcriptional regulator YcdC, C-terminal domain protein YP_001167659.1 PFAM: regulatory protein, TetR; Tetracycline transcriptional regulator YcdC, C-terminal domain protein YP_001167660.1 allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide YP_001167661.1 catalyzes the hydrolytic cleavage of hydantoin with aromatic side chains at the 5'position YP_001167662.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001167663.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001167664.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001167666.1 catalyzes the formation of 3-methyl-2-oxobutanoate from 2,3,-dihydroxy-3-methylbutanoate YP_001167667.1 PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding YP_001167668.1 PFAM: short-chain dehydrogenase/reductase SDR YP_001167669.1 PFAM: fumarylacetoacetate (FAA) hydrolase YP_001167670.1 PFAM: helix-turn-helix domain protein YP_001167671.1 PFAM: response regulator receiver YP_001167673.1 PFAM: ATP-binding region, ATPase domain protein; histidine kinase A domain protein YP_001167674.1 PFAM: surface presentation of antigens (SPOA) protein YP_001167675.1 PFAM: protein of unknown function DUF442 YP_001167680.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001167681.1 PFAM: CinA domain protein YP_001167682.1 PFAM: phosphatidylglycerophosphatase A YP_001167683.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate YP_001167684.1 TIGRFAM: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; PFAM: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase YP_001167685.1 TIGRFAM: putative TIM-barrel protein, nifR3 family; PFAM: dihydrouridine synthase, DuS YP_001167686.1 PFAM: ATP-binding region, ATPase domain protein; histidine kinase A domain protein; PAS fold-4 domain protein YP_001167687.1 PFAM: response regulator receiver; sigma-54 factor, interaction domain-containing protein; helix-turn-helix, Fis-type; SMART: AAA ATPase YP_001167688.1 TIGRFAM: PAS sensor protein; PFAM: ATP-binding region, ATPase domain protein; histidine kinase, HAMP region domain protein; histidine kinase A domain protein; PAS fold-4 domain protein; PAS fold domain protein YP_001167689.1 PFAM: response regulator receiver; sigma-54 factor, interaction domain-containing protein; helix-turn-helix, Fis-type; SMART: AAA ATPase YP_001167690.1 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain YP_001167691.1 PFAM: cation transporter YP_001167692.1 Stimulates the elongation of poly(A) tails YP_001167693.1 PFAM: GTP-binding protein, HSR1-related YP_001167694.1 PFAM: peptidase S45, penicillin amidase YP_001167695.1 PFAM: NADP oxidoreductase, coenzyme F420-dependent; 6-phosphogluconate dehydrogenase, NAD-binding YP_001167697.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate YP_001167699.1 TIGRFAM: transcription-repair coupling factor; PFAM: helicase domain protein; transcription factor CarD; TRCF domain protein; type III restriction enzyme, res subunit; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases-like YP_001167700.1 PFAM: major facilitator superfamily MFS_1 YP_001167701.1 PFAM: DSBA oxidoreductase YP_001167702.1 PFAM: regulatory protein, TetR YP_001167703.1 TIGRFAM: efflux transporter, RND family, MFP subunit; PFAM: secretion protein HlyD family protein YP_001167704.1 PFAM: acriflavin resistance protein YP_001167705.1 PFAM: extracellular solute-binding protein, family 5 YP_001167706.1 TIGRFAM: 3-hydroxybutyrate dehydrogenase; PFAM: short-chain dehydrogenase/reductase SDR YP_001167707.1 PFAM: Indigoidine synthase A family protein YP_001167708.1 PFAM: PfkB domain protein YP_001167709.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit YP_001167710.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu YP_001167711.1 PFAM: ribulose-phosphate 3-epimerase YP_001167712.1 PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; HI0933 family protein; FAD dependent oxidoreductase; FAD-dependent pyridine nucleotide-disulphide oxidoreductase YP_001167713.1 catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide YP_001167714.1 PFAM: NnrS family protein YP_001167715.1 PFAM: protein of unknown function DUF1636 YP_001167716.1 TIGRFAM: cobalamin biosynthesis protein CobW; PFAM: cobalamin synthesis protein, P47K; cobalamin synthesis CobW domain protein YP_001167717.1 with CobST catalyzes the formation of cobyrinic acid a,c-diamide from hydrogenobyrinic acid a,c-diamide in an ATP-dependent manner; involved in porphyrin and chlorophyll metabolism; vitamin B12 metabolism YP_001167718.1 catalyzes the interconversion of precorrin-8X and hydrogenobyrinate YP_001167719.1 TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase YP_001167720.1 TIGRFAM: precorrin-3B C17-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase YP_001167721.1 CobK/CbiJ; there are 2 pathways for cobalamin (vitamin B12) production, one aerobic (ex. P. denitrificans), the other anaerobic (ex. S. typhimurium); the CobK/CbiJ perform similar reactions in both; the anaerobic pathway includes the use of a chelated cobalt ion in order for ring contraction to occur; CobK thus converts precorrin 6 into dihydro-precorrin 6 while CbiJ converts cobalt-precorrin 6 into cobalt-deihydro-precorrin 6 YP_001167722.1 TIGRFAM: precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase YP_001167724.1 TIGRFAM: precorrin-4 C11-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase YP_001167725.1 catalyzes 2 sequential methylations, the formation of precorrin-1 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and uroporphyrin III, and the formation of precorrin-2 and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and precorrin-1 YP_001167726.1 catalyzes the formation of precorrin 6x from precorrin 5 YP_001167727.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis YP_001167728.1 catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis YP_001167730.1 PFAM: phage integrase family protein; phage integrase domain protein SAM domain protein YP_001167731.1 PFAM: CBS domain containing protein; protein of unknown function DUF21; transporter-associated region YP_001167734.1 PFAM: protein of unknown function DUF305 YP_001167735.1 PFAM: peptidase C26 YP_001167736.1 PFAM: regulatory protein, LacI; periplasmic binding protein/LacI transcriptional regulator YP_001167737.1 PFAM: Enoyl-CoA hydratase/isomerase YP_001167738.1 PFAM: MaoC domain protein dehydratase YP_001167739.1 PFAM: HpcH/HpaI aldolase YP_001167740.1 PFAM: coenzyme A transferase YP_001167741.1 PFAM: TRAP dicarboxylate transporter- DctP subunit YP_001167742.1 PFAM: TRAP dicarboxylate transporter- DctP subunit YP_001167743.1 TIGRFAM: TRAP dicarboxylate transporter, DctM subunit; PFAM: TRAP C4-dicarboxylate transport system permease DctM subunit YP_001167744.1 PFAM: Tripartite ATP-independent periplasmic transporter, DctQ component YP_001167745.1 PFAM: Enoyl-CoA hydratase/isomerase YP_001167746.1 PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; FAD dependent oxidoreductase; FAD-dependent pyridine nucleotide-disulphide oxidoreductase YP_001167747.1 PFAM: acyl-CoA dehydrogenase domain protein; Acyl-CoA dehydrogenase, type 2, C-terminal domain YP_001167749.1 PFAM: TRAP dicarboxylate transporter- DctP subunit YP_001167750.1 PFAM: amidohydrolase 2 YP_001167751.1 TIGRFAM: TRAP dicarboxylate transporter, DctM subunit; PFAM: Citrate transporter; TRAP C4-dicarboxylate transport system permease DctM subunit YP_001167753.1 PFAM: short-chain dehydrogenase/reductase SDR; KR YP_001167754.1 PFAM: coenzyme A transferase YP_001167755.1 PFAM: regulatory protein GntR, HTH; GntR domain protein YP_001167756.1 PFAM: transcription factor CarD YP_001167757.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein YP_001167758.1 PFAM: RNA-binding S4 domain protein YP_001167759.1 PFAM: TPR repeat-containing protein; Tetratricopeptide TPR_2 repeat protein; SMART: Tetratricopeptide domain protein YP_001167760.1 PFAM: Sterol-binding domain protein YP_001167761.1 PFAM: alpha/beta hydrolase fold YP_001167762.1 PFAM: 20S proteasome, A and B subunits YP_001167763.1 PFAM: transglutaminase domain protein; transglutaminase, N-terminal domain protein YP_001167764.1 PFAM: protein of unknown function DUF403 YP_001167765.1 PFAM: protein of unknown function DUF404; protein of unknown function DUF407 YP_001167767.1 catalyzes the ATP-dependent formation of a phosphodiester at the site of a single strand break in duplex DNA YP_001167768.1 TIGRFAM: oligoendopeptidase, pepF/M3 family; PFAM: peptidase M3A and M3B, thimet/oligopeptidase F; Oligopeptidase F YP_001167769.1 PFAM: Methyltransferase type 11; Methyltransferase type 12 YP_001167770.1 binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters YP_001167771.1 TIGRFAM: pseudouridine synthase, RluA family; PFAM: RNA-binding S4 domain protein; pseudouridine synthase YP_001167773.1 PFAM: response regulator receiver; ATP-binding region, ATPase domain protein; histidine kinase A domain protein YP_001167775.1 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z YP_001167776.1 PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; FAD dependent oxidoreductase YP_001167777.1 catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine YP_001167779.1 PFAM: NAD(P) transhydrogenase, beta subunit YP_001167780.1 forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm YP_001167782.1 TIGRFAM: kynureninase; PFAM: aminotransferase, class V YP_001167783.1 PFAM: ErfK/YbiS/YcfS/YnhG family protein YP_001167784.1 PFAM: Alcohol dehydrogenase, zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein YP_001167785.1 PFAM: PRC-barrel domain protein YP_001167787.1 PFAM: peptidase M48, Ste24p YP_001167789.1 PFAM: NADPH-dependent FMN reductase; flavodoxin/nitric oxide synthase YP_001167790.1 PFAM: PfkB domain protein YP_001167791.1 NH(3)-dependent; catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers YP_001167792.1 PFAM: MORN repeat-containing protein YP_001167793.1 TIGRFAM: nitrite reductase, copper-containing; PFAM: multicopper oxidase, type 1; multicopper oxidase, type 2 YP_001167794.1 PFAM: protein of unknown function DUF323 YP_001167795.1 TIGRFAM: pseudoazurin; PFAM: blue (type 1) copper domain protein YP_001167796.1 catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis YP_001167798.1 functions in MreBCD complex in some organisms YP_001167799.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall YP_001167801.1 PFAM: penicillin-binding protein, transpeptidase; Penicillin-binding protein, dimerisation domain YP_001167802.1 TIGRFAM: rod shape-determining protein RodA; PFAM: cell cycle protein YP_001167803.1 PFAM: helix-turn-helix protein RpiR; sugar isomerase (SIS) YP_001167804.1 PFAM: N-formylglutamate amidohydrolase YP_001167805.1 PFAM: Tripartite ATP-independent periplasmic transporter, DctQ component YP_001167806.1 PFAM: TRAP C4-dicarboxylate transport system permease DctM subunit YP_001167807.1 PFAM: TRAP dicarboxylate transporter- DctP subunit YP_001167808.1 PFAM: glutamine synthetase, catalytic region YP_001167809.1 PFAM: aldehyde dehydrogenase YP_001167810.1 PFAM: iron-containing alcohol dehydrogenase YP_001167811.1 PFAM: FAD dependent oxidoreductase YP_001167813.1 PFAM: aldo/keto reductase YP_001167814.1 TIGRFAM: RNA polymerase sigma factor, FliA/WhiG family; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70, region 4 type 2 YP_001167816.1 TIGRFAM: flagellar biosynthesis protein FlhA; PFAM: type III secretion FHIPEP protein YP_001167817.1 PFAM: protein of unknown function DUF400 YP_001167822.1 PFAM: Sel1 domain protein repeat-containing protein YP_001167828.1 PFAM: CheW domain protein; Hpt domain protein YP_001167829.1 PFAM: response regulator receiver YP_001167830.1 PFAM: chemotaxis sensory transducer; SMART: histidine kinase, HAMP region domain protein YP_001167831.1 PFAM: Cobyrinic acid a,c-diamide synthase YP_001167832.1 PFAM: CheW domain protein YP_001167833.1 PFAM: CheB methylesterase; response regulator receiver YP_001167834.1 PFAM: MCP methyltransferase, CheR-type YP_001167835.1 PFAM: CheW domain protein; ATP-binding region, ATPase domain protein; Signal transducing histidine kinase, homodimeric YP_001167837.1 PFAM: sigma-54 factor, interaction domain-containing protein; ATPase associated with various cellular activities, AAA_5; SMART: AAA ATPase YP_001167838.1 TIGRFAM: flagellar hook-basal body complex subunit FliE; PFAM: flagellar hook-basal body complex protein FliE YP_001167839.1 TIGRFAM: flagellar M-ring protein FliF; PFAM: secretory protein YscJ/FliF family protein; Flagellar M-ring C-terminal domain protein YP_001167840.1 PFAM: flagellar motor switch protein FliG YP_001167842.1 TIGRFAM: ATPase, FliI/YscN family; PFAM: H+-transporting two-sector ATPase, alpha/beta subunit, central region; SMART: AAA ATPase YP_001167844.1 PFAM: flagellar hook-length control protein YP_001167845.1 PFAM: flagellar basal body-associated protein FliL YP_001167846.1 PFAM: surface presentation of antigens (SPOA) protein; flagellar motor switch protein FliM YP_001167847.1 TIGRFAM: flagellar motor switch protein FliN; PFAM: surface presentation of antigens (SPOA) protein YP_001167849.1 FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus YP_001167850.1 TIGRFAM: flagellar biosynthetic protein FliQ; PFAM: export protein FliQ, family 3 YP_001167851.1 TIGRFAM: flagellar biosynthetic protein FliR; PFAM: type III secretion system inner membrane R protein YP_001167852.1 TIGRFAM: flagellar biosynthetic protein FlhB; PFAM: type III secretion exporter YP_001167855.1 TIGRFAM: RNA polymerase sigma-54 factor, RpoN; PFAM: sigma-54 factor; sigma-54 factor, core-binding region; sigma-54, DNA-binding domain protein YP_001167856.1 PFAM: flagellin domain protein; flagellin hook IN repeat protein YP_001167857.1 PFAM: flagellar hook-associated 2 domain protein YP_001167858.1 PFAM: sigma-54 factor, interaction domain-containing protein; helix-turn-helix, Fis-type; ATPase associated with various cellular activities, AAA_5; SMART: AAA ATPase YP_001167859.1 PFAM: Lytic transglycosylase, catalytic YP_001167861.1 TIGRFAM: flagellar hook-associated protein FlgK; PFAM: flagellar basal body rod protein; flagellin hook IN repeat protein; protein of unknown function DUF1078 domain protein YP_001167863.1 part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum YP_001167864.1 PFAM: flagellar L-ring protein YP_001167865.1 TIGRFAM: flagellar basal-body rod protein FlgG; PFAM: flagellar basal body rod protein; protein of unknown function DUF1078 domain protein YP_001167866.1 PFAM: protein of unknown function DUF1078 domain protein YP_001167867.1 PFAM: flagellar basal body rod protein; protein of unknown function DUF1078 domain protein; flagellar basal body FlaE domain protein YP_001167868.1 PFAM: flagellar hook capping protein YP_001167869.1 TIGRFAM: flagellar basal-body rod protein FlgC; PFAM: flagellar basal body rod protein YP_001167870.1 TIGRFAM: flagellar basal-body rod protein FlgB YP_001167872.1 TIGRFAM: PAS sensor protein; PFAM: response regulator receiver; ATP-binding region, ATPase domain protein; histidine kinase A domain protein; Hpt domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein YP_001167874.1 PFAM: regulatory protein, LuxR; response regulator receiver YP_001167876.1 PFAM: protein of unknown function DUF892 YP_001167877.1 TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: Haloacid dehalogenase domain protein hydrolase YP_001167878.1 PFAM: putative sugar-binding domain protein YP_001167879.1 PFAM: extracellular solute-binding protein, family 1 YP_001167880.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001167881.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001167882.1 PFAM: ABC transporter related; TOBE domain protein; Transport-associated OB domain protein; SMART: AAA ATPase YP_001167883.1 PFAM: Mannitol dehydrogenase, C-terminal domain; Mannitol dehydrogenase rossman, N-terminal domain YP_001167884.1 PFAM: TRAP dicarboxylate transporter- DctP subunit YP_001167885.1 TIGRFAM: TRAP dicarboxylate transporter, DctM subunit; PFAM: TRAP C4-dicarboxylate transport system permease DctM subunit YP_001167886.1 PFAM: Tripartite ATP-independent periplasmic transporter, DctQ component YP_001167887.1 PFAM: NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 YP_001167888.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen YP_001167889.1 NuoCD; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; subunits NuoCD, E, F, and G constitute the peripheral sector of the complex; in Escherichia coli this gene encodes a fusion protein of NuoC and NuoD that are found separate in other organisms YP_001167890.1 Catalyzes the transfer of electrons from NADH to quinone YP_001167891.1 PFAM: Respiratory-chain NADH dehydrogenase domain, 51 kDa subunit YP_001167892.1 Catalyzes the transfer of electrons from NADH to quinone YP_001167893.1 PFAM: respiratory-chain NADH dehydrogenase, subunit 1 YP_001167894.1 Catalyzes the transfer of electrons from NADH to quinone YP_001167895.1 PFAM: NADH-ubiquinone/plastoquinone oxidoreductase, chain 6 YP_001167896.1 PFAM: NADH-ubiquinone oxidoreductase, chain 4L YP_001167897.1 TIGRFAM: proton-translocating NADH-quinone oxidoreductase, chain L; PFAM: NADH/Ubiquinone/plastoquinone (complex I) YP_001167898.1 TIGRFAM: proton-translocating NADH-quinone oxidoreductase, chain M; PFAM: NADH/Ubiquinone/plastoquinone (complex I) YP_001167899.1 PFAM: NADH/Ubiquinone/plastoquinone (complex I) YP_001167900.1 PFAM: phospholipase D/Transphosphatidylase YP_001167902.1 TIGRFAM: cytochrome c, monohaem; PFAM: cytochrome c oxidase, subunit I; cytochrome c, class I YP_001167903.1 TIGRFAM: cytochrome c, monohaem; PFAM: cytochrome c oxidase, subunit II; cytochrome c, class I YP_001167904.1 PFAM: phosphoesterase, PA-phosphatase related YP_001167905.1 PFAM: Autoinducer-binding domain protein YP_001167906.1 PFAM: regulatory protein, LuxR; Autoinducer-binding domain protein YP_001167907.1 PFAM: regulatory protein, LuxR; Autoinducer-binding domain protein; Bacterio-opsin activator, HTH domain protein YP_001167908.1 PFAM: autoinducer synthesis protein YP_001167910.1 involved in the biosynthesis of osmoregulated periplasmic glucans; required for the assembly of the polyglucose structure of glucan YP_001167911.1 necessary for biosynthesis of osmoregulated periplasmic glucans possibly involved in the transfer to the periplasmic space YP_001167914.1 PFAM: trimethylamine methyltransferase YP_001167916.1 PFAM: Mammalian cell entry related domain protein YP_001167917.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001167918.1 PFAM: protein of unknown function DUF140 YP_001167919.1 PFAM: phage integrase family protein YP_001167926.1 PFAM: phage Gp37Gp68 family protein YP_001167938.1 PFAM: helix-turn-helix domain protein YP_001167942.1 PFAM: Chromosomal replication initiator, DnaA C-terminal domain YP_001167946.1 PFAM: HNH endonuclease; SMART: HNH nuclease YP_001167948.1 PFAM: phage Terminase YP_001167949.1 TIGRFAM: phage portal protein, HK97 family; PFAM: phage portal protein YP_001167950.1 PFAM: peptidase S49 YP_001167951.1 PFAM: phage major capsid protein, HK97 YP_001167954.1 TIGRFAM: phage head-tail adaptor, putative YP_001167956.1 TIGRFAM: phage protein, HK97 gp10 family; PFAM: TP901-1 ORF40 family protein YP_001167959.1 TIGRFAM: phage tape measure protein YP_001167971.1 PFAM: protein of unknown function DUF395, YeeE/YedE YP_001167972.1 PFAM: Rhodanese domain protein YP_001167973.1 PFAM: Endoribonuclease L-PSP YP_001167974.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family YP_001167975.1 TIGRFAM: 6-phosphogluconolactonase YP_001167976.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate YP_001167977.1 TIGRFAM: malto-oligosyltrehalose synthase; PFAM: alpha amylase, catalytic region; SMART: alpha amylase, catalytic sub domain YP_001167978.1 TIGRFAM: 4-alpha-glucanotransferase; PFAM: glycoside hydrolase, family 77 YP_001167979.1 TIGRFAM: malto-oligosyltrehalose trehalohydrolase; PFAM: glycoside hydrolase, family 13 domain protein; alpha amylase, catalytic region; SMART: alpha amylase, catalytic sub domain YP_001167980.1 TIGRFAM: glycogen debranching enzyme GlgX; PFAM: glycoside hydrolase, family 13 domain protein; alpha amylase, catalytic region; SMART: alpha amylase, catalytic sub domain YP_001167981.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain YP_001167982.1 TIGRFAM: trehalose synthase; trehalose synthase-fused possible maltokinase; PFAM: alpha amylase, catalytic region; SMART: alpha amylase, catalytic sub domain YP_001167983.1 PFAM: alpha amylase, catalytic region; SMART: alpha amylase, catalytic sub domain YP_001167985.1 PFAM: response regulator receiver YP_001167986.1 PFAM: histidine kinase, HAMP region domain protein; chemotaxis sensory transducer YP_001167988.1 PFAM: chemotaxis sensory transducer YP_001167989.1 catalyzes the conversion of glutamine residues to glutamate on methyl-accepting chemotaxis receptors YP_001167991.1 PFAM: response regulator receiver YP_001167992.1 PFAM: CheW domain protein; ATP-binding region, ATPase domain protein; Signal transducing histidine kinase, homodimeric; Hpt domain protein YP_001167993.1 PFAM: CheW domain protein YP_001167994.1 PFAM: MCP methyltransferase, CheR-type YP_001167995.1 PFAM: response regulator receiver YP_001167998.1 PFAM: transposase, IS111A/IS1328/IS1533; transposase IS116/IS110/IS902 family protein YP_001168000.1 PFAM: transposase IS3/IS911 family protein YP_001168001.1 PFAM: transposase IS3/IS911 family protein YP_001168002.1 PFAM: transposase, IS4 family protein YP_001168004.1 PFAM: transposase IS3/IS911 family protein YP_001168005.1 PFAM: IS66 Orf2 family protein YP_001168006.1 PFAM: transposase IS66 YP_001168007.1 PFAM: IstB domain protein ATP-binding protein; IstB ATP binding N-terminal domain protein; SMART: AAA ATPase YP_001168008.1 PFAM: Integrase, catalytic region YP_001168011.1 PFAM: Integrase, catalytic region YP_001168012.1 PFAM: transposase, IS4 family protein YP_001168013.1 TIGRFAM: single-strand binding protein; PFAM: single-strand binding protein/Primosomal replication protein n YP_001168016.1 PFAM: ERF family protein YP_001168017.1 PFAM: transposase, IS4 family protein YP_001168019.1 PFAM: UvrD/REP helicase; DNA topoisomerase, type IA, zn finger domain protein YP_001168022.1 PFAM: plasmid stabilization system YP_001168023.1 PFAM: transposase IS3/IS911 family protein YP_001168025.1 PFAM: transposase, IS111A/IS1328/IS1533; transposase IS116/IS110/IS902 family protein YP_001168027.1 PFAM: IstB domain protein ATP-binding protein; SMART: AAA ATPase YP_001168028.1 PFAM: Integrase, catalytic region YP_001168029.1 PFAM: IstB domain protein ATP-binding protein YP_001168035.1 PFAM: transposase, IS4 family protein YP_001168038.1 PFAM: protein of unknown function UPF0126 YP_001168040.1 PFAM: cyclic nucleotide-binding; SMART: regulatory protein, Crp YP_001168041.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate YP_001168042.1 PFAM: major facilitator superfamily MFS_1 YP_001168043.1 E3 component of pyruvate complex; catalyzes the oxidation of dihydrolipoamide to lipoamide YP_001168044.1 PFAM: protein of unknown function DUF924 YP_001168045.1 PFAM: major facilitator superfamily MFS_1 YP_001168046.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step YP_001168048.1 PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; Redoxin domain protein YP_001168049.1 PFAM: peptidase M23B YP_001168050.1 PFAM: protein of unknown function DUF583 YP_001168052.1 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1 YP_001168053.1 TIGRFAM: penicillin-binding protein, 1A family; PFAM: glycosyl transferase, family 51; penicillin-binding protein, transpeptidase YP_001168054.1 PFAM: cell wall hydrolase/autolysin YP_001168055.1 PFAM: aminotransferase, class I and II YP_001168056.1 PFAM: DSBA oxidoreductase YP_001168057.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis YP_001168059.1 catalyzes the formation of 5-aminolevulinate from succinyl-CoA and glycine YP_001168061.1 PFAM: peptidase M20; peptidase dimerisation domain protein YP_001168062.1 PFAM: GCN5-related N-acetyltransferase YP_001168063.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway YP_001168064.1 PFAM: ABC transporter, transmembrane region; ABC transporter related; SMART: AAA ATPase YP_001168065.1 PFAM: Peptidoglycan-binding LysM YP_001168066.1 PFAM: conserved hypothetical protein 730 YP_001168067.1 PFAM: manganese and iron superoxide dismutase YP_001168068.1 PFAM: acyltransferase 3 YP_001168069.1 PFAM: Sarcosine oxidase, gamma subunit YP_001168070.1 TIGRFAM: sarcosine oxidase, alpha subunit family; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel YP_001168071.1 PFAM: Sarcosine oxidase, delta subunit, heterotetrameric YP_001168073.1 TIGRFAM: sarcosine oxidase, beta subunit family; PFAM: FAD dependent oxidoreductase YP_001168075.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function YP_001168076.1 PFAM: NnrU family protein YP_001168077.1 TIGRFAM: 2'-5' RNA ligase; PFAM: 2',5' RNA ligase YP_001168078.1 PFAM: histone deacetylase superfamily YP_001168079.1 PFAM: glutathione peroxidase YP_001168080.1 PFAM: NUDIX hydrolase YP_001168081.1 PFAM: protein of unknown function DUF1178 YP_001168082.1 isomerizes methylthioribose-1-phosphate into methylthioribulose-1-phosphate; involved in methionine salvage pathway YP_001168083.1 PFAM: phosphate-starvation-inducible E YP_001168087.1 PFAM: protein of unknown function DUF1469 YP_001168090.1 responsible for recognizing base lesions in the genome and initiating base excision DNA repair YP_001168092.1 PFAM: Catalase domain protein YP_001168095.1 converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism YP_001168096.1 catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine YP_001168097.1 PFAM: protein of unknown function UPF0061 YP_001168099.1 PFAM: response regulator receiver; transcriptional regulator domain protein YP_001168100.1 PFAM: protein of unknown function DUF1153 YP_001168101.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs YP_001168103.1 TIGRFAM: methionine-R-sulfoxide reductase; PFAM: Methionine sulfoxide reductase B YP_001168104.1 PFAM: SmpA/OmlA domain protein YP_001168106.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not YP_001168107.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY YP_001168108.1 TIGRFAM: 3-oxoacyl-(acyl-carrier-protein) synthase III; PFAM: 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal domain protein; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III YP_001168109.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control YP_001168110.1 PFAM: regulatory protein, MerR YP_001168111.1 Catalyzes the deamination of dCTP to form dUTP YP_001168112.1 PFAM: flavin reductase domain protein, FMN-binding YP_001168113.1 PFAM: regulatory protein, ArsR YP_001168114.1 PFAM: protein of unknown function DUF159 YP_001168116.1 TIGRFAM: phosphate ABC transporter, inner membrane subunit PstC; PFAM: binding-protein-dependent transport systems inner membrane component YP_001168117.1 TIGRFAM: phosphate ABC transporter, inner membrane subunit PstA; PFAM: binding-protein-dependent transport systems inner membrane component YP_001168118.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation YP_001168119.1 TIGRFAM: phosphate transport system regulatory protein PhoU; PFAM: PhoU family protein YP_001168120.1 TIGRFAM: phosphate regulon transcriptional regulatory protein PhoB; PFAM: response regulator receiver; transcriptional regulator domain protein YP_001168121.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001168123.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001168126.1 PFAM: response regulator receiver; ATP-binding region, ATPase domain protein; histidine kinase A domain protein YP_001168127.1 PFAM: domain of unknown function DUF1745 YP_001168128.1 PFAM: regulatory protein, LuxR; response regulator receiver YP_001168130.1 PFAM: beta-lactamase domain protein YP_001168132.1 PFAM: ABC-2 type transporter YP_001168133.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001168136.1 TIGRFAM: 40-residue YVTN family beta-propeller repeat protein YP_001168139.1 SMART: extracellular solute-binding protein, family 3 YP_001168141.1 PFAM: Pyrrolo-quinoline quinone YP_001168142.1 PFAM: cytochrome c, class I YP_001168143.1 PFAM: Alcohol dehydrogenase, zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein YP_001168144.1 catalyzes the reaction of formaldehyde with glutathione to form S-hydroxymethylglutathione YP_001168147.1 PFAM: cyclic nucleotide-binding; regulatory protein, Crp YP_001168148.1 PFAM: luciferase family protein YP_001168149.1 TIGRFAM: intracellular protease, PfpI family; PFAM: ThiJ/PfpI domain protein YP_001168150.1 PFAM: NAD-dependent epimerase/dehydratase YP_001168151.1 PFAM: glycosyl transferase, family 8 YP_001168152.1 PFAM: NAD-dependent epimerase/dehydratase; 3-beta hydroxysteroid dehydrogenase/isomerase; dTDP-4-dehydrorhamnose reductase YP_001168153.1 PFAM: Nucleotidyl transferase YP_001168155.1 PFAM: glycosyl transferase, family 2 YP_001168156.1 PFAM: glycosyl transferase, family 2 YP_001168157.1 PFAM: lipopolysaccharide biosynthesis protein YP_001168159.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001168161.1 PFAM: asparagine synthase YP_001168166.1 PFAM: glycosyl transferase, family 2 YP_001168167.1 PFAM: glycosyl transferase, family 2 YP_001168168.1 PFAM: glycoside hydrolase, family 16 YP_001168169.1 PFAM: O-antigen polymerase YP_001168170.1 PFAM: polysaccharide export protein YP_001168171.1 PFAM: sugar transferase YP_001168173.1 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate YP_001168174.1 TIGRFAM: protein-L-isoaspartate O-methyltransferase; PFAM: protein-L-isoaspartate(D-aspartate) O-methyltransferase YP_001168175.1 PFAM: Peptidoglycan-binding LysM; peptidase M23B YP_001168176.1 PFAM: protein of unknown function DUF815; SMART: AAA ATPase YP_001168177.1 TIGRFAM: Sec-independent protein translocase, TatC subunit; PFAM: Sec-independent periplasmic protein translocase YP_001168178.1 TIGRFAM: twin-arginine translocation protein, TatB subunit; PFAM: sec-independent translocation protein mttA/Hcf106 YP_001168179.1 TIGRFAM: twin-arginine translocation protein, TatA/E family subunit; PFAM: sec-independent translocation protein mttA/Hcf106 YP_001168180.1 PFAM: ABC transporter related; TOBE domain protein; Transport-associated OB domain protein; SMART: AAA ATPase YP_001168181.1 PFAM: short-chain dehydrogenase/reductase SDR YP_001168182.1 TIGRFAM: peptide chain release factor 3; small GTP-binding protein; PFAM: protein synthesis factor, GTP-binding; elongation factor Tu, domain 2 protein YP_001168183.1 PFAM: helicase domain protein; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases-like YP_001168184.1 PFAM: beta-lactamase domain protein; RNA-metabolising metallo-beta-lactamase YP_001168185.1 type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP YP_001168186.1 TIGRFAM: biotin--acetyl-CoA-carboxylase ligase; PFAM: biotin protein ligase domain protein; biotin/lipoate A/B protein ligase YP_001168187.1 Catalyzes the transfer of electrons from NADH to quinone YP_001168188.1 Catalyzes the transfer of electrons from NADH to quinone YP_001168189.1 Catalyzes the transfer of electrons from NADH to ubiquinone YP_001168190.1 Catalyzes the transfer of electrons from NADH to quinone YP_001168191.1 Catalyzes the transfer of electrons from NADH to quinone YP_001168192.1 PFAM: Carboxymuconolactone decarboxylase YP_001168193.1 Catalyzes the transfer of electrons from NADH to quinone YP_001168194.1 Catalyzes the transfer of electrons from NADH to quinone YP_001168196.1 Catalyzes the transfer of electrons from NADH to quinone YP_001168197.1 part of NADH-ubiquinone oxidoreductase complex I; shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase YP_001168199.1 Catalyzes the transfer of electrons from NADH to quinone YP_001168200.1 Catalyzes the transfer of electrons from NADH to quinone YP_001168201.1 Catalyzes the transfer of electrons from NADH to quinone YP_001168202.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen YP_001168203.1 Catalyzes the transfer of electrons from NADH to quinone YP_001168204.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_001168205.1 catalyzes the formation of acetoacetate and acetyl-CoA from 3-hydroxy-3-methylglutaryl-CoA YP_001168206.1 PFAM: biotin/lipoyl attachment domain-containing protein; phosphoribosylglycinamide synthetase; ATP-dependent carboxylate-amine ligase domain protein, ATP-grasp; Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein YP_001168207.1 PFAM: carboxyl transferase YP_001168208.1 PFAM: OmpW family protein YP_001168209.1 PFAM: acyl-CoA dehydrogenase domain protein; Acyl-CoA dehydrogenase, type 2, C-terminal domain YP_001168210.1 PFAM: CreA family protein YP_001168211.1 TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: Haloacid dehalogenase domain protein hydrolase YP_001168212.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis YP_001168213.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source YP_001168214.1 PFAM: aminotransferase, class V YP_001168215.1 PFAM: ABC transporter, transmembrane region; SMC domain protein; ABC transporter related; SMART: AAA ATPase YP_001168216.1 PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein, C-terminal barrel YP_001168217.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA YP_001168220.1 TIGRFAM: type I secretion outer membrane protein, TolC family; PFAM: outer membrane efflux protein YP_001168221.1 PFAM: protein-L-isoaspartate(D-aspartate) O-methyltransferase; Methyltransferase type 11; Methyltransferase type 12 YP_001168222.1 PFAM: FAD dependent oxidoreductase YP_001168223.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate YP_001168225.1 TIGRFAM: photosynthetic reaction center, M subunit; PFAM: photosynthetic reaction centre protein YP_001168226.1 TIGRFAM: photosynthetic reaction center L subunit; PFAM: photosynthetic reaction centre protein YP_001168227.1 PFAM: antenna complex, alpha/beta subunit YP_001168228.1 PFAM: antenna complex, alpha/beta subunit YP_001168229.1 PFAM: PufQ cytochrome subunit YP_001168230.1 TIGRFAM: chlorophyllide reductase subunit Z; PFAM: oxidoreductase/nitrogenase, component 1; protein of unknown function DUF1197 YP_001168231.1 TIGRFAM: chlorophyllide reductase subunit Y YP_001168232.1 TIGRFAM: chlorophyllide reductase iron protein subunit X; PFAM: NifH/frxC-family protein YP_001168233.1 TIGRFAM: chlorophyll synthesis pathway, BchC; PFAM: Alcohol dehydrogenase GroES domain protein YP_001168234.1 PFAM: O-methyltransferase, family 2 YP_001168235.1 PFAM: Polyprenyl synthetase YP_001168236.1 TIGRFAM: Phytoene dehydrogenase-related protein; PFAM: amine oxidase; FAD dependent oxidoreductase YP_001168237.1 PFAM: hydroxyneurosporene synthase YP_001168238.1 PFAM: dihydrodipicolinate synthetase YP_001168239.1 PFAM: LamB/YcsF family protein YP_001168240.1 PFAM: TRAP dicarboxylate transporter- DctP subunit YP_001168241.1 PFAM: Tripartite ATP-independent periplasmic transporter, DctQ component YP_001168242.1 TIGRFAM: TRAP dicarboxylate transporter, DctM subunit; PFAM: TRAP C4-dicarboxylate transport system permease DctM subunit YP_001168243.1 PFAM: Allophanate hydrolase subunit 1 YP_001168244.1 TIGRFAM: urea amidolyase related protein; PFAM: Allophanate hydrolase subunit 2 YP_001168245.1 PFAM: regulatory protein GntR, HTH; GntR domain protein YP_001168246.1 PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding YP_001168247.1 allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide YP_001168248.1 PFAM: regulatory protein GntR, HTH; GntR domain protein YP_001168249.1 PFAM: creatinase; peptidase M24 YP_001168250.1 PFAM: Acetamidase/Formamidase YP_001168251.1 PFAM: 6-phosphogluconate dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding YP_001168252.1 PFAM: Dimethylmenaquinone methyltransferase YP_001168253.1 PFAM: short-chain dehydrogenase/reductase SDR YP_001168254.1 PFAM: aminotransferase, class I and II YP_001168255.1 PFAM: Endoribonuclease L-PSP YP_001168256.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate YP_001168257.1 PFAM: regulatory protein, LysR; LysR, substrate-binding YP_001168258.1 PFAM: extracellular solute-binding protein, family 3 YP_001168259.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001168260.1 TIGRFAM: polar amino acid ABC transporter, inner membrane subunit; PFAM: binding-protein-dependent transport systems inner membrane component YP_001168261.1 TIGRFAM: polar amino acid ABC transporter, inner membrane subunit; PFAM: binding-protein-dependent transport systems inner membrane component YP_001168262.1 PFAM: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase YP_001168263.1 catalyzes the hydrolytic cleavage of imides that range from linear to heterocyclic and that include hydantoins, dihydropyrimidines, and phthalimides YP_001168264.1 PFAM: Asp/Glu racemase YP_001168265.1 PFAM: regulatory protein, LysR; LysR, substrate-binding YP_001168267.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA YP_001168268.1 TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain YP_001168269.1 PFAM: Methyltransferase type 11; Methyltransferase type 12 YP_001168271.1 PFAM: major facilitator superfamily MFS_1 YP_001168272.1 PFAM: HhH-GPD family protein YP_001168273.1 PFAM: phospholipase/Carboxylesterase YP_001168275.1 PFAM: RNA-directed DNA polymerase (Reverse transcriptase) YP_001168290.1 PFAM: protein of unknown function DUF1320 YP_001168295.1 TIGRFAM: phage virion morphogenesis protein YP_001168296.1 PFAM: phage putative head morphogenesis protein, SPP1 gp7 YP_001168297.1 PFAM: protein of unknown function DUF935 YP_001168299.1 PFAM: protein of unknown function DUF264 YP_001168305.1 PFAM: N-acetylmuramoyl-L-alanine amidase, family 2; SH3, type 3 domain protein; SMART: SH3 domain protein YP_001168308.1 PFAM: MT-A70 family protein YP_001168310.1 PFAM: protein of unknown function DUF1018 YP_001168313.1 PFAM: Chromosomal replication initiator, DnaA C-terminal domain YP_001168317.1 PFAM: Integrase, catalytic region YP_001168318.1 PFAM: ParB domain protein nuclease YP_001168322.1 PFAM: histone family protein DNA-binding protein YP_001168324.1 PFAM: peptidase S24, S26A and S26B YP_001168325.1 PFAM: HNH endonuclease; SMART: HNH nuclease YP_001168326.1 PFAM: Integrase, catalytic region YP_001168327.1 PFAM: IstB domain protein ATP-binding protein; SMART: AAA ATPase YP_001168328.1 PFAM: transposase, IS4 family protein YP_001168329.1 PFAM: IstB domain protein ATP-binding protein YP_001168331.1 TIGRFAM: prevent-host-death family protein; PFAM: protein of unknown function DUF172 YP_001168332.1 PFAM: Lysine exporter protein (LYSE/YGGA) YP_001168333.1 PFAM: regulatory protein, AsnC/Lrp family YP_001168335.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001168336.1 TIGRFAM: lipid-A-disaccharide synthase; PFAM: glycosyl transferase, family 19 YP_001168337.1 PFAM: protein of unknown function DUF1009 YP_001168338.1 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis YP_001168339.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP YP_001168340.1 PFAM: outer membrane chaperone Skp (OmpH) YP_001168341.1 PFAM: surface antigen (D15); surface antigen variable number repeat protein YP_001168343.1 TIGRFAM: putative membrane-associated zinc metalloprotease; PFAM: PDZ/DHR/GLGF domain protein; peptidase M50 YP_001168344.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate YP_001168345.1 PFAM: phosphatidate cytidylyltransferase YP_001168346.1 TIGRFAM: undecaprenyl diphosphate synthase; PFAM: Di-trans-poly-cis-decaprenylcistransferase YP_001168347.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs YP_001168348.1 Catalyzes the phosphorylation of UMP to UDP YP_001168349.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity YP_001168350.1 PFAM: helix-turn-helix- domain containing protein, AraC type YP_001168351.1 PFAM: extracellular solute-binding protein, family 5 YP_001168352.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001168353.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001168354.1 TIGRFAM: oligopeptide/dipeptide ABC transporter, ATPase subunit; PFAM: ABC transporter related; Oligopeptide/dipeptide ABC transporter, C-terminal domain protein; SMART: AAA ATPase YP_001168355.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains YP_001168356.1 PFAM: Pyrrolo-quinoline quinone YP_001168358.1 PFAM: protein of unknown function DUF6, transmembrane YP_001168359.1 PFAM: membrane protein involved in aromatic hydrocarbon degradation YP_001168361.1 catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis YP_001168362.1 PFAM: alpha/beta hydrolase fold YP_001168363.1 PFAM: protein of unknown function DUF344 YP_001168364.1 PFAM: regulatory protein, TetR YP_001168365.1 TIGRFAM: spermidine/putrescine ABC transporter ATPase subunit; PFAM: ABC transporter related; Transport-associated OB domain protein; SMART: AAA ATPase YP_001168366.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001168367.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001168368.1 PFAM: regulatory protein GntR, HTH; aminotransferase, class I and II YP_001168370.1 forms a direct contact with the tRNA during translation YP_001168371.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit YP_001168373.1 TIGRFAM: dTDP-4-dehydrorhamnose 3,5-epimerase; PFAM: dTDP-4-dehydrorhamnose 3,5-epimerase related YP_001168374.1 PFAM: oxidoreductase domain protein; SAF domain YP_001168375.1 PFAM: NAD-dependent epimerase/dehydratase; 3-beta hydroxysteroid dehydrogenase/isomerase; dTDP-4-dehydrorhamnose reductase YP_001168377.1 PFAM: short-chain dehydrogenase/reductase SDR; KR YP_001168378.1 PFAM: acetyl-CoA hydrolase/transferase YP_001168379.1 TIGRFAM: PAS sensor protein; diguanylate cyclase; PFAM: GGDEF domain containing protein; EAL domain protein; PAS fold-3 domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein; PAC repeat-containing protein YP_001168382.1 PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding YP_001168383.1 PFAM: protein of unknown function DUF1058 YP_001168384.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is not essential for growth YP_001168385.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring YP_001168386.1 PFAM: GumN family protein YP_001168388.1 catalyzes the hydrolysis of pyrophosphate to phosphate YP_001168389.1 TIGRFAM: HAD-superfamily subfamily IIA hydrolase like protein; HAD-superfamily hydrolase, subfamily IIA; PFAM: Haloacid dehalogenase domain protein hydrolase YP_001168390.1 PFAM: MaoC domain protein dehydratase YP_001168391.1 TIGRFAM: riboflavin biosynthesis protein RibF; PFAM: Riboflavin kinase / FAD synthetase YP_001168392.1 PFAM: protein of unknown function UPF0153 YP_001168393.1 PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase YP_001168394.1 TIGRFAM: ribose-phosphate pyrophosphokinase; PFAM: phosphoribosyltransferase YP_001168395.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the epsilon subunit is part of the catalytic core of the ATP synthase complex YP_001168396.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit YP_001168397.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit YP_001168398.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit YP_001168399.1 TIGRFAM: ATP synthase F1, delta subunit; PFAM: H+-transporting two-sector ATPase, delta (OSCP) subunit YP_001168401.1 PFAM: beta-lactamase domain protein YP_001168402.1 TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase, central domain protein; Clp N terminal domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase YP_001168403.1 PFAM: OmpA/MotB domain protein YP_001168405.1 PFAM: ChaC family protein YP_001168406.1 PFAM: Extensin family protein YP_001168407.1 dual function enzyme catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate and the formation of tyrosine from arogenate YP_001168408.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis YP_001168409.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination YP_001168410.1 PFAM: response regulator receiver; transcriptional regulator domain protein YP_001168411.1 TIGRFAM: PAS sensor protein; PFAM: response regulator receiver; ATP-binding region, ATPase domain protein; histidine kinase A domain protein; PAS fold-4 domain protein YP_001168412.1 PFAM: AMP-dependent synthetase and ligase YP_001168413.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001168414.1 PFAM: inner-membrane translocator YP_001168415.1 PFAM: inner-membrane translocator YP_001168417.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001168419.1 PFAM: N-acetylmuramoyl-L-alanine amidase, family 2 YP_001168421.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_001168422.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain YP_001168424.1 PFAM: beta-lactamase domain protein YP_001168425.1 PFAM: CMP/dCMP deaminase, zinc-binding YP_001168426.1 PFAM: RNA-binding S4 domain protein; pseudouridine synthase YP_001168428.1 PFAM: toxic anion resistance family protein YP_001168433.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase YP_001168434.1 PFAM: PfkB domain protein YP_001168435.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine YP_001168436.1 activates fatty acids by binding to coenzyme A YP_001168437.1 TIGRFAM: lipid A ABC exporter family, fused ATPase and inner membrane subunits; PFAM: ABC transporter, transmembrane region; ABC transporter related; SMART: AAA ATPase YP_001168438.1 PFAM: alpha/beta hydrolase fold YP_001168439.1 PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit YP_001168440.1 TIGRFAM: 3-oxoadipate enol-lactonase; PFAM: alpha/beta hydrolase fold YP_001168442.1 PFAM: major facilitator superfamily MFS_1 YP_001168443.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_001168444.1 catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis YP_001168445.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide YP_001168446.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide YP_001168447.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase YP_001168448.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis YP_001168449.1 PFAM: CoA-binding domain protein YP_001168450.1 TIGRFAM: RNA methyltransferase, TrmH family, group 3; PFAM: tRNA/rRNA methyltransferase (SpoU); RNA 2-O ribose methyltransferase, substrate binding YP_001168451.1 TIGRFAM: drug resistance transporter, EmrB/QacA subfamily; PFAM: major facilitator superfamily MFS_1 YP_001168452.1 PFAM: secretion protein HlyD family protein YP_001168453.1 PFAM: regulatory protein, MarR YP_001168454.1 PFAM: beta-lactamase YP_001168455.1 PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB YP_001168456.1 TIGRFAM: phage SPO1 DNA polymerase-related protein; PFAM: Uracil-DNA glycosylase superfamily YP_001168459.1 TIGRFAM: PAS sensor protein; PFAM: CheB methylesterase; MCP methyltransferase, CheR-type; HWE histidine kinase; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein YP_001168461.1 PFAM: Nucleotidyl transferase YP_001168462.1 TIGRFAM: glycogen debranching enzyme GlgX; PFAM: glycoside hydrolase, family 13 domain protein; alpha amylase, catalytic region; SMART: alpha amylase, catalytic sub domain YP_001168464.1 TIGRFAM: efflux transporter, RND family, MFP subunit; PFAM: secretion protein HlyD family protein YP_001168465.1 PFAM: acriflavin resistance protein YP_001168466.1 PFAM: protein of unknown function DUF333 YP_001168467.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide YP_001168469.1 PFAM: flagellar motor switch protein FliG YP_001168470.1 PFAM: lipid A biosynthesis acyltransferase YP_001168471.1 PFAM: ErfK/YbiS/YcfS/YnhG family protein YP_001168472.1 PFAM: aminotransferase, class IV YP_001168473.1 PFAM: UspA domain protein YP_001168474.1 PFAM: nitrogen-fixing NifU domain protein YP_001168475.1 PFAM: peptidase M22, glycoprotease YP_001168476.1 PFAM: GCN5-related N-acetyltransferase YP_001168477.1 PFAM: basic membrane lipoprotein YP_001168478.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001168479.1 PFAM: inner-membrane translocator YP_001168480.1 PFAM: inner-membrane translocator YP_001168481.1 catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation YP_001168482.1 PFAM: protein of unknown function DUF81 YP_001168484.1 PFAM: thioesterase superfamily protein YP_001168485.1 PFAM: regulatory protein, MerR YP_001168486.1 PFAM: regulatory protein, MerR YP_001168487.1 PFAM: acyl-CoA dehydrogenase domain protein YP_001168488.1 PFAM: glutathione-dependent formaldehyde-activating, GFA YP_001168489.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_001168490.1 PFAM: Enoyl-CoA hydratase/isomerase; 3-hydroxyacyl-CoA dehydrogenase domain protein; 3-hydroxyacyl-CoA dehydrogenase, NAD-binding YP_001168491.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine YP_001168492.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor YP_001168493.2 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein YP_001168494.1 MDM; functions in conversion of succinate to propionate YP_001168496.1 PFAM: biotin/lipoyl attachment domain-containing protein; ATP-dependent carboxylate-amine ligase domain protein, ATP-grasp; Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; RimK domain protein ATP-grasp YP_001168499.1 PFAM: carboxyl transferase YP_001168500.1 PFAM: protein of unknown function DUF486 YP_001168501.1 TIGRFAM: drug resistance transporter, Bcr/CflA subfamily; PFAM: major facilitator superfamily MFS_1 YP_001168502.1 PFAM: helix-turn-helix domain protein; protein of unknown function DUF955 YP_001168503.1 PFAM: nuclease (SNase domain protein) YP_001168504.1 catalyzes the oxidation of choline to betaine aldehyde and betain aldehyde to glycine betaine YP_001168505.1 catalyzes the formation of betaine from betaine aldehyde YP_001168506.1 HTH-type; bet1; Repressor involved in choline regulation of the bet genes YP_001168507.1 PFAM: Substrate-binding region of ABC-type glycine betaine transport system YP_001168508.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001168509.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001168510.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity YP_001168511.1 TIGRFAM: DNA protecting protein DprA; PFAM: SMF family protein YP_001168512.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001168514.1 PFAM: BioY protein YP_001168515.1 TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase YP_001168516.1 PFAM: regulatory protein, LysR; LysR, substrate-binding YP_001168517.1 PFAM: phosphate transporter YP_001168518.1 PFAM: inositol monophosphatase YP_001168519.1 PFAM: Rhomboid family protein YP_001168520.1 proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichia coli this protein self regulates transcription via a DNA-binding domain at the N-terminus but the protein from Pseudomonas does not have this domain YP_001168521.1 PFAM: regulatory protein, AsnC/Lrp family YP_001168522.1 TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein YP_001168523.1 PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding YP_001168526.1 PFAM: CHAD domain containing protein YP_001168527.1 TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein YP_001168528.1 PFAM: Heme NO binding domain protein YP_001168530.1 TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: Haloacid dehalogenase domain protein hydrolase YP_001168531.1 TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; response regulator receiver YP_001168534.1 Bacteria have multiple sigma factors which are active under specific conditions; the sigma factor binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription YP_001168536.1 PFAM: protein of unknown function DUF983 YP_001168537.1 PFAM: NUDIX hydrolase YP_001168539.1 PFAM: Lipocalin family protein YP_001168541.1 PFAM: aldo/keto reductase YP_001168543.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content YP_001168544.1 PFAM: cyclic nucleotide-binding; sodium/hydrogen exchanger YP_001168547.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001168549.1 TIGRFAM: cobalamin biosynthesis protein CobD; PFAM: cobalamin biosynthesis protein CbiB YP_001168550.1 TIGRFAM: cysteine desulfurase, SufS subfamily; PFAM: aminotransferase, class V; Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; aromatic amino acid beta-eliminating lyase/threonine aldolase; aminotransferase, class I and II YP_001168553.1 PFAM: SufBD protein YP_001168554.1 TIGRFAM: FeS assembly ATPase SufC; PFAM: ABC transporter related; SMART: AAA ATPase YP_001168555.1 PFAM: protein of unknown function DUF74 YP_001168556.1 with SufCD activates cysteine desulfurase SufS YP_001168557.1 PFAM: aminotransferase, class V YP_001168558.1 TIGRFAM: putative transcriptional regulator, Rrf2 family; PFAM: protein of unknown function UPF0074 YP_001168561.1 Converts isocitrate to alpha ketoglutarate YP_001168562.1 PFAM: protein of unknown function DUF161 YP_001168563.1 TIGRFAM: small GTP-binding protein; GTP-binding protein TypA; PFAM: elongation factor G domain protein; protein synthesis factor, GTP-binding; elongation factor Tu, domain 2 protein YP_001168565.1 PFAM: protein of unknown function DUF1330 YP_001168566.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001168567.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs YP_001168569.1 PFAM: response regulator receiver; ATP-binding region, ATPase domain protein; histidine kinase A domain protein YP_001168570.1 PFAM: Fmu (Sun) domain protein YP_001168571.1 PFAM: regulatory protein, DeoR; Helix-turn-helix, type 11 domain protein YP_001168574.1 PFAM: protein of unknown function DUF475 YP_001168576.1 PFAM: acriflavin resistance protein YP_001168577.1 TIGRFAM: efflux transporter, RND family, MFP subunit YP_001168578.1 TIGRFAM: cation diffusion facilitator family transporter; PFAM: cation efflux protein YP_001168579.1 PFAM: peptidase U32 YP_001168580.1 PFAM: peptidase U32 YP_001168582.1 TIGRFAM: UbiD family decarboxylase; PFAM: Carboxylyase-related protein YP_001168583.1 TIGRFAM: 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; PFAM: flavoprotein YP_001168584.1 catalyzed the formation of 2-ketoglutarate from 2-hydroxyglutarate YP_001168585.1 PFAM: C4-dicarboxylate transporter/malic acid transport protein YP_001168588.1 PFAM: Endonuclease/exonuclease/phosphatase YP_001168589.1 PFAM: phospholipase D/Transphosphatidylase YP_001168590.1 PFAM: cytochrome c, class II YP_001168591.1 PFAM: cytochrome B561 YP_001168592.1 PFAM: class II aldolase/adducin family protein YP_001168593.1 PFAM: protein of unknown function DUF542, ScdA domain protein; Hemerythrin HHE cation binding domain protein YP_001168595.1 PFAM: IS66 Orf2 family protein YP_001168596.1 PFAM: tRNA synthetase, class II (D, K and N) YP_001168597.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA YP_001168598.1 PFAM: Mannitol dehydrogenase, C-terminal domain; Mannitol dehydrogenase rossman, N-terminal domain YP_001168599.1 TIGRFAM: 2-deoxy-D-gluconate 3-dehydrogenase; PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; KR YP_001168600.1 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; catalyzes the interconversion of 4-deoxy-L-threo-5-hexosulose uronate to 3-deoxy-D-glycero-2,5-hexodiulosonate YP_001168601.1 PFAM: Cupin 2, conserved barrel domain protein YP_001168602.1 TIGRFAM: TRAP dicarboxylate transporter, DctM subunit; PFAM: TRAP C4-dicarboxylate transport system permease DctM subunit YP_001168603.1 PFAM: Tripartite ATP-independent periplasmic transporter, DctQ component YP_001168604.1 TIGRFAM: TRAP dicarboxylate transporter, DctP subunit; PFAM: TRAP dicarboxylate transporter- DctP subunit YP_001168605.1 catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; functions in glucuronic and galacturonic metabolism YP_001168606.1 PFAM: regulatory protein GntR, HTH; GntR domain protein YP_001168607.1 PFAM: PfkB domain protein YP_001168610.1 PFAM: peptidase S1 and S6, chymotrypsin/Hap YP_001168613.1 SMART: DNA/RNA non-specific endonuclease YP_001168614.1 SMART: Rhodanese domain protein YP_001168615.1 PFAM: regulatory protein, LuxR; response regulator receiver YP_001168616.1 TIGRFAM: PAS sensor protein; PFAM: response regulator receiver; ATP-binding region, ATPase domain protein; histidine kinase A domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein YP_001168617.1 PFAM: glycoside hydrolase, family 16; Hemolysin-type calcium-binding region YP_001168618.1 PFAM: NAD-dependent epimerase/dehydratase; 3-beta hydroxysteroid dehydrogenase/isomerase; dTDP-4-dehydrorhamnose reductase; Male sterility C-terminal domain YP_001168622.1 PFAM: glycosyl transferase, group 1 YP_001168623.1 PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; 3-beta hydroxysteroid dehydrogenase/isomerase; dTDP-4-dehydrorhamnose reductase; Male sterility C-terminal domain YP_001168624.1 PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; 3-beta hydroxysteroid dehydrogenase/isomerase; dTDP-4-dehydrorhamnose reductase; NmrA family protein; Male sterility C-terminal domain YP_001168625.1 PFAM: Alcohol dehydrogenase, zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein YP_001168626.1 PFAM: oxidoreductase domain protein; Oxidoreductase, C-terminal domain YP_001168627.1 PFAM: Ku domain protein YP_001168628.1 PFAM: Alcohol dehydrogenase, zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein YP_001168629.1 TIGRFAM: rpsU-divergently transcribed protein; PFAM: COQ9 domain protein YP_001168630.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA YP_001168631.1 catalyzes the decarboxylaton of phospatidyl-L-sering to phosphatidylethanolamine YP_001168632.1 PFAM: CDP-alcohol phosphatidyltransferase YP_001168633.1 PFAM: UbiE/COQ5 methyltransferase; Methyltransferase type 11; Methyltransferase type 12 YP_001168634.1 PFAM: regulatory protein, AsnC/Lrp family; regulatory protein, MarR; Helix-turn-helix, type 11 domain protein YP_001168635.1 TIGRFAM: alanine dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; alanine dehydrogenase/PNT domain protein YP_001168636.1 homopentamer; channel that opens in response to pressure or hypoosmotic shock YP_001168637.1 PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; Redoxin domain protein YP_001168638.1 catalyzes the formation of arginine from (N-L-arginino)succinate YP_001168641.1 TIGRFAM: diaminopimelate decarboxylase; PFAM: Orn/DAP/Arg decarboxylase 2 YP_001168643.1 TIGRFAM: MJ0042 family finger-like protein YP_001168644.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001168645.1 PFAM: protein of unknown function DUF214 YP_001168646.1 PFAM: phospholipid/glycerol acyltransferase YP_001168647.1 PFAM: GCN5-related N-acetyltransferase YP_001168648.1 TIGRFAM: molybdopterin-guanine dinucleotide biosynthesis protein B; PFAM: molybdopterin-guanine dinucleotide biosynthesis MobB region YP_001168649.1 TIGRFAM: molybdopterin-guanine dinucleotide biosynthesis protein A; PFAM: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase YP_001168650.1 PFAM: AzlC family protein YP_001168651.1 PFAM: branched-chain amino acid transport YP_001168653.1 PFAM: aa3 type cytochrome c oxidase subunit IV YP_001168654.1 PFAM: beta-lactamase domain protein YP_001168655.1 PFAM: acyl-CoA dehydrogenase domain protein; Acyl-CoA dehydrogenase, type 2, C-terminal domain YP_001168656.1 TIGRFAM: Sua5/YciO/YrdC/YwlC family protein; PFAM: SUA5 domain protein; SUA5/yciO/yrdC, N-terminal domain YP_001168657.1 TIGRFAM: DNA-3-methyladenine glycosylase I; PFAM: methyladenine glycosylase YP_001168658.1 PFAM: EAL domain protein YP_001168659.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis YP_001168660.1 TIGRFAM: acetoacetyl-CoA reductase; PFAM: short-chain dehydrogenase/reductase SDR; KR YP_001168661.1 PFAM: protein of unknown function DUF465 YP_001168662.1 PFAM: methyltransferase small YP_001168663.1 PFAM: Polyprenyl synthetase YP_001168664.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis YP_001168665.1 PFAM: TPR repeat-containing protein; Tetratricopeptide TPR_2 repeat protein; SMART: Tetratricopeptide domain protein YP_001168666.1 PFAM: FAD dependent oxidoreductase; electron transfer flavoprotein-ubiquinone oxidoreductase YP_001168667.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus YP_001168669.1 PFAM: glucose sorbosone dehydrogenase YP_001168671.1 PFAM: small multidrug resistance protein YP_001168672.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein YP_001168673.1 PFAM: transcription activator, effector binding YP_001168674.1 PFAM: HpcH/HpaI aldolase YP_001168675.1 PFAM: protein of unknown function DUF1611 YP_001168676.1 PFAM: Mandelate racemase/muconate lactonizing enzyme, N-terminal domain protein; Mandelate racemase/muconate lactonizing enzyme, C-terminal domain protein YP_001168677.1 PFAM: aminotransferase, class IV YP_001168678.1 PFAM: N-formylglutamate amidohydrolase YP_001168679.1 PFAM: pyruvate kinase YP_001168680.1 PFAM: ribosomal protein L35 YP_001168681.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit YP_001168682.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily YP_001168684.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily YP_001168685.1 PFAM: protein of unknown function DUF1523 YP_001168687.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica. YP_001168688.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine YP_001168689.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate YP_001168690.1 PFAM: ErfK/YbiS/YcfS/YnhG family protein YP_001168691.1 PFAM: creatinase; peptidase M24 YP_001168692.1 PFAM: ferredoxin YP_001168693.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001168694.1 TIGRFAM: polar amino acid ABC transporter, inner membrane subunit; PFAM: binding-protein-dependent transport systems inner membrane component YP_001168695.1 TIGRFAM: polar amino acid ABC transporter, inner membrane subunit; PFAM: binding-protein-dependent transport systems inner membrane component YP_001168696.1 TIGRFAM: cationic amino acid ABC transporter, periplasmic binding protein; PFAM: extracellular solute-binding protein, family 3 YP_001168697.1 PFAM: ATP12 ATPase YP_001168698.1 TIGRFAM: pseudouridine synthase, RluA family; PFAM: RNA-binding S4 domain protein; pseudouridine synthase YP_001168699.1 PFAM: AAA ATPase, central domain protein; ATPase associated with various cellular activities, AAA_5; SMART: AAA ATPase YP_001168700.1 TIGRFAM: protease Do; PFAM: peptidase S1 and S6, chymotrypsin/Hap; SMART: PDZ/DHR/GLGF domain protein YP_001168701.1 PFAM: regulatory protein, LuxR; Autoinducer-binding domain protein YP_001168702.1 is a component of the macrolide binding site in the peptidyl transferase center YP_001168703.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme YP_001168704.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 YP_001168705.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA YP_001168706.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP YP_001168707.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase YP_001168708.1 late assembly protein YP_001168709.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7 YP_001168710.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance YP_001168711.1 binds 5S rRNA along with protein L5 and L25 YP_001168712.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance YP_001168713.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit YP_001168714.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif YP_001168715.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 YP_001168716.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel YP_001168717.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase YP_001168718.1 primary binding protein; helps mediate assembly; involved in translation fidelity YP_001168719.1 one of the stabilizing components for the large ribosomal subunit YP_001168720.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e YP_001168721.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation YP_001168722.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center YP_001168723.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA YP_001168724.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation YP_001168725.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel YP_001168726.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA YP_001168727.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin YP_001168728.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex YP_001168729.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_001168730.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_001168731.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit YP_001168732.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance YP_001168733.1 PFAM: protein of unknown function DUF6, transmembrane YP_001168734.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter YP_001168735.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme YP_001168736.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors YP_001168737.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit YP_001168738.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA YP_001168739.1 binds directly to 23S ribosomal RNA YP_001168740.1 TIGRFAM: transcription termination/antitermination factor NusG; PFAM: transcription antitermination protein NusG; KOW domain protein; SMART: NGN domain protein; KOW (Kyrpides, Ouzounis, Woese) domain protein YP_001168741.1 forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force YP_001168742.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_001168744.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_001168745.1 PFAM: SH3, type 3 domain protein; SMART: SH3 domain protein YP_001168746.1 PFAM: short-chain dehydrogenase/reductase SDR; KR YP_001168748.1 TIGRFAM: ATP--cobalamin adenosyltransferase; PFAM: cobalamin adenosyltransferase YP_001168749.1 PFAM: electron transfer flavoprotein beta-subunit YP_001168750.1 PFAM: electron transfer flavoprotein beta-subunit; electron transfer flavoprotein, alpha subunit YP_001168752.1 converts (S)-3-hydroxybutanoyl-CoA to 3-acetoacetyl-CoA YP_001168753.1 TIGRFAM: phosphocarrier, HPr family; PFAM: phosphocarrier HPr protein YP_001168754.1 PFAM: PTS system fructose subfamily IIA component YP_001168755.1 PFAM: uncharacterised P-loop ATPase protein UPF0042 YP_001168757.1 PFAM: ATP-binding region, ATPase domain protein; histidine kinase, HAMP region domain protein; histidine kinase A domain protein YP_001168759.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP YP_001168760.1 PFAM: acyl-CoA dehydrogenase domain protein; Acyl-CoA dehydrogenase, type 2, C-terminal domain YP_001168761.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA YP_001168762.1 PFAM: protein of unknown function DUF1491 YP_001168763.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome YP_001168764.1 PFAM: ribonuclease III; double-stranded RNA binding domain protein YP_001168765.1 TIGRFAM: signal peptidase I; PFAM: peptidase S24, S26A and S26B YP_001168766.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids YP_001168767.1 involved in the de novo synthesis of pyridoxine (Vitamin B6) YP_001168769.1 TIGRFAM: RelA/SpoT family protein; PFAM: amino acid-binding ACT domain protein; TGS domain protein; metal-dependent phosphohydrolase, HD sub domain; RelA/SpoT domain protein; SMART: metal-dependent phosphohydrolase, HD region YP_001168770.1 Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits YP_001168771.1 TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK YP_001168772.1 PFAM: protein of unknown function DUF88 YP_001168773.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway YP_001168775.1 PFAM: regulatory protein, LacI; periplasmic binding protein/LacI transcriptional regulator YP_001168777.1 PFAM: peptidase S49 YP_001168778.1 PFAM: GCN5-related N-acetyltransferase YP_001168781.1 PFAM: Ig family protein YP_001168784.1 PFAM: Enoyl-CoA hydratase/isomerase YP_001168785.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases YP_001168786.1 TIGRFAM: ubiquinone/menaquinone biosynthesis methyltransferase; PFAM: UbiE/COQ5 methyltransferase; Methyltransferase type 11; Methyltransferase type 12 YP_001168787.1 TIGRFAM: 2-polyprenylphenol 6-hydroxylase; PFAM: ABC-1 domain protein YP_001168788.1 acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod; Rhodobacter sphaeroides has 2 copies of many flagellar genes; the Rhodobacter protein in this cluster is associated with a set of flagellar genes acquired by lateral gene transfer; these genes are not normally expressed YP_001168792.1 TIGRFAM: ATPase, FliI/YscN family; PFAM: H+-transporting two-sector ATPase, alpha/beta subunit, central region; SMART: AAA ATPase YP_001168793.1 with FlgF and C makes up the proximal portion of the flagellar basal body rod YP_001168794.1 with FlgF and B makes up the proximal portion of the flagellar basal body rod YP_001168795.1 forms a junction between the M-ring and FlgB during flagella biosynthesis; Bradyrhizobium has one thick flagellum and several thin flagella; the protein in this cluster is associated with the thin flagella YP_001168796.1 PFAM: export protein FliQ, family 3 YP_001168797.1 FlgF, with FlgB and C, makes up the proximal portion of the flagellar basal body rod; Rhodobacter sphaeroides has 2 copies of this and other flagella genes YP_001168798.1 makes up the distal portion of the flagellar basal body rod; Bradyrhizobium has one thick flagellum and several thin flagella; the Bradyrhizobium protein in this cluster is associated with the thick flagella YP_001168799.1 required for the assembly of the flagellar basal body P-ring YP_001168800.1 part of the flagellar basal body which consists of four rings L,P, S and M mounted on a central rod YP_001168802.1 PFAM: transposase, IS4 family protein YP_001168803.1 membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export YP_001168804.1 PFAM: type III secretion system inner membrane R protein YP_001168805.1 membrane protein involved in the flagellar export apparatus YP_001168806.1 PFAM: Lytic transglycosylase, catalytic YP_001168807.1 catalyzes the interconversion of D-xylose to D-xylulose YP_001168808.1 TIGRFAM: xylulokinase; PFAM: carbohydrate kinase, FGGY YP_001168809.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001168810.1 PFAM: inner-membrane translocator YP_001168811.1 TIGRFAM: D-xylose ABC transporter, periplasmic substrate-binding protein YP_001168812.1 PFAM: ROK family protein YP_001168813.1 PFAM: surface antigen (D15); surface antigen variable number repeat protein YP_001168814.1 PFAM: protein of unknown function DUF490 YP_001168815.1 TIGRFAM: putative ribonuclease BN; PFAM: ribonuclease BN YP_001168818.1 PFAM: protein of unknown function DUF940, membrane lipoprotein putative YP_001168819.1 PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; 3-beta hydroxysteroid dehydrogenase/isomerase; polysaccharide biosynthesis protein CapD; dTDP-4-dehydrorhamnose reductase; Male sterility C-terminal domain YP_001168820.1 PFAM: sugar transferase YP_001168821.1 PFAM: NAD-dependent epimerase/dehydratase YP_001168822.1 PFAM: regulatory protein, MarR YP_001168823.1 PFAM: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase YP_001168824.1 TIGRFAM: glutaredoxin 3; PFAM: glutaredoxin YP_001168827.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic YP_001168829.1 PFAM: ErfK/YbiS/YcfS/YnhG family protein YP_001168830.1 PFAM: Allergen V5/Tpx-1 family protein YP_001168831.1 PFAM: ErfK/YbiS/YcfS/YnhG family protein YP_001168833.1 PFAM: ABC transporter, transmembrane region; ABC transporter related; SMART: AAA ATPase YP_001168834.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001168835.1 PFAM: Polynucleotide adenylyltransferase region YP_001168836.1 PFAM: NUDIX hydrolase YP_001168837.1 PFAM: Hsp33 protein YP_001168838.1 PFAM: NUDIX hydrolase YP_001168839.1 PFAM: response regulator receiver; Stage II sporulation E family protein; SMART: protein phosphatase 2C domain protein YP_001168840.1 PFAM: Hpt domain protein YP_001168841.1 catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic YP_001168842.1 catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming YP_001168843.1 PFAM: protein of unknown function DUF533 YP_001168845.1 PFAM: aminotransferase, class IV YP_001168846.1 NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate YP_001168847.1 This protein performs the mismatch recognition step during the DNA repair process YP_001168848.1 PFAM: GrpE protein YP_001168849.1 Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons YP_001168850.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs YP_001168851.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine YP_001168852.1 PFAM: Endoribonuclease L-PSP YP_001168853.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_001168854.1 PFAM: protein of unknown function DUF454 YP_001168855.1 TIGRFAM: parB-like partition protein; PFAM: ParB domain protein nuclease YP_001168856.1 PFAM: Cobyrinic acid a,c-diamide synthase YP_001168857.1 TIGRFAM: methyltransferase GidB; PFAM: glucose inhibited division protein YP_001168858.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs YP_001168859.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE YP_001168860.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes YP_001168861.1 PFAM: conserved hypothetical protein 701 YP_001168862.1 PFAM: Maf family protein YP_001168863.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate YP_001168864.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis YP_001168865.1 TIGRFAM: DNA polymerase III, epsilon subunit; PFAM: Exonuclease, RNase T and DNA polymerase III; SMART: Exonuclease YP_001168866.1 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA YP_001168867.1 PFAM: FxsA cytoplasmic membrane protein YP_001168868.1 PFAM: import inner membrane translocase, subunit Tim44 YP_001168869.1 PFAM: MltA domain protein; 3D domain protein YP_001168870.1 PFAM: Smr protein/MutS2 YP_001168871.1 PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase YP_001168872.1 PFAM: regulatory protein, LacI; periplasmic binding protein/LacI transcriptional regulator YP_001168873.1 PFAM: AP endonuclease 2 domain protein; Xylose isomerase domain protein TIM barrel YP_001168874.1 PFAM: oxidoreductase domain protein; Oxidoreductase, C-terminal domain YP_001168875.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001168876.1 PFAM: inner-membrane translocator YP_001168878.1 TIGRFAM: pseudoazurin; PFAM: blue (type 1) copper domain protein YP_001168881.1 PFAM: 2-nitropropane dioxygenase, NPD YP_001168882.1 PFAM: sodium/sulphate symporter; Citrate transporter; TrkA-C domain protein; TRAP C4-dicarboxylate transport system permease DctM subunit YP_001168884.1 TIGRFAM: acetate kinase; PFAM: acetate and butyrate kinase YP_001168885.1 PFAM: phosphate acetyl/butaryl transferase; MaoC domain protein dehydratase YP_001168886.1 Catalyzes a key regulatory step in fatty acid biosynthesis YP_001168887.1 PFAM: alpha/beta hydrolase fold; Poly-beta-hydroxybutyrate polymerase domain protein YP_001168888.1 PFAM: alpha/beta hydrolase fold YP_001168891.1 PFAM: CsbD family protein YP_001168892.1 PFAM: ATP-binding region, ATPase domain protein; histidine kinase, HAMP region domain protein; histidine kinase, dimerisation/phosphoacceptor YP_001168893.1 Bacteria have multiple sigma factors which are active under specific conditions; the sigma factor binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription YP_001168895.1 in Caulobacter crescentus, CC3477 is differentially expressed in minimal salts media with glucose as compared to complex media YP_001168897.1 PFAM: cyclic nucleotide-binding YP_001168899.1 PFAM: N-acylglucosamine 2-epimerase YP_001168900.1 catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate YP_001168901.1 TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; PFAM: Haloacid dehalogenase domain protein hydrolase YP_001168902.1 PFAM: AAA ATPase, central domain protein; SMART: AAA ATPase YP_001168903.1 PFAM: ribulose bisphosphate carboxylase, small chain YP_001168904.1 type III RuBisCO; involved in carbon fixation YP_001168905.1 class II aldolase; catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle, glycolysis and gluconeogenesis YP_001168906.1 PFAM: phosphoribulokinase/uridine kinase YP_001168907.1 PFAM: Inositol phosphatase/fructose-1,6-bisphosphatase YP_001168908.1 PFAM: regulatory protein, LysR; LysR, substrate-binding YP_001168909.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001168910.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001168911.1 PFAM: inner-membrane translocator YP_001168914.1 PFAM: phage integrase family protein YP_001168915.1 TIGRFAM: alkylhydroperoxidase like protein, AhpD family; uncharacterized peroxidase-related enzyme; PFAM: Carboxymuconolactone decarboxylase YP_001168917.1 PFAM: aldehyde dehydrogenase YP_001168919.1 PFAM: dehydrogenase, E1 component; Transketolase, central region; Transketolase domain protein YP_001168920.1 PFAM: acyl-CoA dehydrogenase domain protein; Acyl-CoA dehydrogenase, type 2, C-terminal domain YP_001168921.1 PFAM: regulatory protein, LysR; LysR, substrate-binding YP_001168922.1 TIGRFAM: N-acetylglucosamine-6-phosphate deacetylase; PFAM: amidohydrolase YP_001168924.1 PFAM: phosphoesterase, PA-phosphatase related YP_001168925.1 PFAM: peptidase S8 and S53, subtilisin, kexin, sedolisin YP_001168928.1 PFAM: flagellar basal body rod protein; protein of unknown function DUF1078 domain protein YP_001168929.1 with FlgL acts as a hook filament junction protein to join the flagellar filament to the hook YP_001168931.1 part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum YP_001168932.1 TIGRFAM: PAS sensor protein; PFAM: response regulator receiver; ATP-binding region, ATPase domain protein; histidine kinase A domain protein; PAS fold-3 domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein; PAC repeat-containing protein YP_001168934.1 FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus YP_001168935.1 PFAM: surface presentation of antigens (SPOA) protein YP_001168937.1 the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L, P, S, and M mounted on a central rod YP_001168938.1 PFAM: flagellar basal body-associated protein FliL YP_001168941.1 With MotB forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine YP_001168943.1 TIGRFAM: UTP-glucose-1-phosphate uridylyltransferase; PFAM: Nucleotidyl transferase YP_001168944.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS YP_001168945.1 TIGRFAM: 3'(2'),5'-bisphosphate nucleotidase; PFAM: inositol monophosphatase YP_001168946.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins YP_001168947.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination YP_001168948.1 PFAM: protein of unknown function DUF448 YP_001168949.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex YP_001168950.1 PFAM: NUDIX hydrolase YP_001168951.1 bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate YP_001168952.1 PFAM: PpiC-type peptidyl-prolyl cis-trans isomerase YP_001168953.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins YP_001168955.1 PFAM: OmpA/MotB domain protein YP_001168956.1 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase YP_001168957.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion YP_001168958.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria YP_001168959.1 TIGRFAM: proline iminopeptidase; PFAM: alpha/beta hydrolase fold YP_001168960.1 Involved in ubiquinone biosynthesis YP_001168961.1 TIGRFAM: PTS IIA-like nitrogen-regulatory protein PtsN; PFAM: phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 YP_001168962.1 TIGRFAM: ribosomal subunit interface protein; PFAM: sigma 54 modulation protein/ribosomal protein S30EA YP_001168963.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001168964.1 PFAM: OstA family protein YP_001168966.1 TIGRFAM: KpsF/GutQ family protein; PFAM: CBS domain containing protein; sugar isomerase (SIS) YP_001168967.1 PFAM: 3'-5' exonuclease YP_001168968.1 PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; 3-beta hydroxysteroid dehydrogenase/isomerase; dTDP-4-dehydrorhamnose reductase; Male sterility C-terminal domain YP_001168969.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell YP_001168970.1 function undetermined; similar to glutamate synthase beta subunit and related oxidoreductases which transfer electrons from NADPH to an acceptor protein or protein domain YP_001168972.1 PFAM: glutathione-dependent formaldehyde-activating, GFA YP_001168973.1 PFAM: glutamine amidotransferase, class-II; glutamate synthase, alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase YP_001168974.1 TIGRFAM: monofunctional biosynthetic peptidoglycan transglycosylase; PFAM: glycosyl transferase, family 51 YP_001168975.1 PFAM: Glutathione S-transferase, N-terminal domain YP_001168976.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; domain of unknown function DUF1730 YP_001168978.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids YP_001168979.1 PFAM: regulatory protein, MarR YP_001168980.1 PFAM: response regulator receiver; transcriptional regulator domain protein YP_001168981.1 PFAM: histone deacetylase superfamily YP_001168982.1 TIGRFAM: exodeoxyribonuclease VII, small subunit; PFAM: Exonuclease VII, small subunit YP_001168983.1 PFAM: Polyprenyl synthetase YP_001168984.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate YP_001168985.1 PFAM: NAD-dependent epimerase/dehydratase; dTDP-4-dehydrorhamnose reductase YP_001168986.1 Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile YP_001168987.1 PFAM: histone family protein DNA-binding protein YP_001168988.1 PFAM: protein of unknown function DUF6, transmembrane YP_001168989.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis YP_001168990.1 part of the thiamine and TPP transport system tbpA-thiPQ YP_001168991.1 permease; with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell; repressed in presence of exogenous thiamine YP_001168992.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001168993.1 PFAM: cytochrome c1 YP_001168994.1 PFAM: Cytochrome b/b6, N-terminal domain; Cytochrome b/b6, C-terminal domain YP_001168995.1 TIGRFAM: ubiquinol-cytochrome c reductase, iron-sulfur subunit; PFAM: Rieske [2Fe-2S] domain protein YP_001168998.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group do not have the motif YP_001168999.1 PFAM: N-formylglutamate amidohydrolase YP_001169000.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function YP_001169001.1 PFAM: band 7 protein YP_001169004.1 type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase YP_001169005.1 PFAM: ROK family protein YP_001169007.1 PFAM: AAA ATPase, central domain protein; Clp N terminal domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase YP_001169008.1 PFAM: beta-Ig-H3/fasciclin YP_001169009.1 in Escherichia coli this periplasmic enzyme was found to encode the periplasmic catalytic subunit of an oxidoreductase; sulfite oxidase activity not demonstrated; requires inner membrane anchor protein YedZ YP_001169010.1 in Escherichia coli this inner membrane protein was found to anchor the periplasmic catalytic oxidoreductase YedY; sulfite oxidase activity not demonstrated; contains heme YP_001169013.1 PFAM: peptidase U35, phage prohead HK97 YP_001169014.1 TIGRFAM: phage portal protein, lambda family; PFAM: phage portal protein, lambda YP_001169015.1 PFAM: transposase, IS4 family protein YP_001169019.1 PFAM: Substrate-binding region of ABC-type glycine betaine transport system YP_001169020.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001169021.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001169022.1 PFAM: helix-turn-helix domain protein YP_001169023.1 PFAM: Citrate transporter; Na+/H+ antiporter NhaC YP_001169024.1 catalyzes the thiolytic cleavage of beta-ketoadipyl-CoA to succinate and acetyl-CoA YP_001169025.1 PFAM: Enoyl-CoA hydratase/isomerase; 3-hydroxyacyl-CoA dehydrogenase domain protein; 3-hydroxyacyl-CoA dehydrogenase, NAD-binding YP_001169026.1 PFAM: aminotransferase class-III YP_001169027.1 PFAM: aldehyde dehydrogenase YP_001169028.1 PFAM: AMP-dependent synthetase and ligase YP_001169029.1 PFAM: FAD dependent oxidoreductase YP_001169030.1 PFAM: amidohydrolase 2 YP_001169031.1 PFAM: regulatory protein, TetR YP_001169032.1 PFAM: histone deacetylase superfamily YP_001169033.1 PFAM: Amidase YP_001169034.1 PFAM: extracellular solute-binding protein, family 5 YP_001169035.1 PFAM: extracellular solute-binding protein, family 5 YP_001169036.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001169037.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001169038.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001169039.1 PFAM: Ion transport protein YP_001169040.1 PFAM: glycosyl transferase, group 1 YP_001169043.1 involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth YP_001169044.1 TIGRFAM: formate dehydrogenase, alpha subunit; PFAM: ferredoxin; 4Fe-4S ferredoxin, iron-sulfur binding domain protein; molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; molybdopterin oxidoreductase Fe4S4 region YP_001169045.1 PFAM: Respiratory-chain NADH dehydrogenase domain, 51 kDa subunit YP_001169046.1 catalyzes the oxidation of formate to carbon dioxide and hydrogen using NAD or NADP as the acceptor YP_001169047.1 PFAM: regulatory protein, LysR; LysR, substrate-binding YP_001169048.1 PFAM: peptidase S49 YP_001169049.1 PFAM: short-chain dehydrogenase/reductase SDR; KR YP_001169050.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision YP_001169051.1 TIGRFAM: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase YP_001169052.1 TIGRFAM: molybdopterin converting factor, subunit 1; PFAM: thiamineS protein YP_001169053.1 PFAM: molybdopterin biosynthesis MoaE protein YP_001169054.1 PFAM: Phosphoglycerate mutase YP_001169056.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate YP_001169057.1 PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR YP_001169058.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential YP_001169059.1 PFAM: MOSC domain containing protein YP_001169060.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria YP_001169061.1 TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; EAL domain protein YP_001169062.1 TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs YP_001169067.1 PFAM: Antibiotic biosynthesis monooxygenase YP_001169070.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion YP_001169071.1 PFAM: ETC complex I subunit conserved region YP_001169074.1 TIGRFAM: carboxynorspermidine decarboxylase; PFAM: Orn/DAP/Arg decarboxylase 2 YP_001169075.1 PFAM: Saccharopine dehydrogenase YP_001169078.1 PFAM: ABC transporter related; Oligopeptide/dipeptide ABC transporter, C-terminal domain protein; SMART: AAA ATPase YP_001169079.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001169080.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001169081.1 PFAM: extracellular solute-binding protein, family 5 YP_001169082.1 PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase YP_001169084.1 PFAM: helicase domain protein; DbpA, RNA-binding domain protein; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases-like YP_001169085.1 TIGRFAM: thioredoxin; PFAM: Tetratricopeptide TPR_4; Thioredoxin domain YP_001169086.1 PFAM: peptidase S16, lon domain protein YP_001169087.1 PFAM: protein of unknown function DUF343 YP_001169088.1 TIGRFAM: Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; PFAM: monooxygenase, FAD-binding YP_001169089.1 PFAM: Amidase YP_001169090.1 PFAM: aminotransferase, class I and II YP_001169091.1 PFAM: cell division FtsK/SpoIIIE YP_001169092.1 PFAM: outer membrane lipoprotein carrier protein LolA YP_001169094.1 TIGRFAM: hemimethylated DNA binding protein; PFAM: Hemimethylated DNA-binding region YP_001169095.1 PFAM: gamma-glutamyltranspeptidase YP_001169096.1 PFAM: ATP-binding region, ATPase domain protein YP_001169097.1 TIGRFAM: anti-anti-sigma factor; PFAM: Sulfate transporter/antisigma-factor antagonist STAS YP_001169098.1 SMART: GAF domain protein YP_001169100.1 PFAM: pseudouridine synthase YP_001169101.1 PFAM: aldehyde dehydrogenase YP_001169102.1 PFAM: HemY domain protein YP_001169104.1 PFAM: Uroporphyrinogen III synthase HEM4 YP_001169105.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity YP_001169106.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate YP_001169107.1 unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity YP_001169108.1 PFAM: protein of unknown function DUF55 YP_001169109.1 PFAM: 3' exoribonuclease; RNA binding S1 domain protein; KH, type 1, domain protein; SMART: KH domain protein YP_001169110.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence YP_001169111.1 PFAM: protein of unknown function DUF1643 YP_001169112.1 TIGRFAM: cysteine synthase; cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit YP_001169113.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs YP_001169115.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock YP_001169116.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis YP_001169117.1 PFAM: Fmu (Sun) domain protein; NusB/RsmB/TIM44; methyltransferase small YP_001169118.1 PFAM: Heparinase II/III family protein YP_001169119.1 involved in de novo purine biosynthesis YP_001169120.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis YP_001169122.1 PFAM: peptidase M16 domain protein YP_001169123.1 PFAM: peptidase M16 domain protein YP_001169124.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex YP_001169125.1 PFAM: protein of unknown function DUF195 YP_001169126.1 TIGRFAM: anti-sigma factor, putative, ChrR family YP_001169127.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response YP_001169128.1 PFAM: FAD dependent oxidoreductase YP_001169129.1 PFAM: protein of unknown function DUF1365 YP_001169132.1 PFAM: short-chain dehydrogenase/reductase SDR; KR YP_001169133.1 PFAM: alanine dehydrogenase/PNT domain protein YP_001169134.1 PFAM: response regulator receiver; transcriptional regulator domain protein YP_001169135.1 TIGRFAM: alpha,alpha-trehalose-phosphate synthase [UDP-forming]; PFAM: glycosyl transferase, family 20 YP_001169136.1 TIGRFAM: HAD-superfamily hydrolase, subfamily IIB; PFAM: trehalose-phosphatase YP_001169137.1 PFAM: glycosyl transferase, family 2 YP_001169138.1 TIGRFAM: glucose-1-phosphate cytidylyltransferase; PFAM: Nucleotidyl transferase YP_001169139.1 heat shock protein involved in degradation of misfolded proteins YP_001169140.1 heat shock protein involved in degradation of misfolded proteins YP_001169141.1 TIGRFAM: thioredoxin; PFAM: Thioredoxin domain YP_001169142.1 TIGRFAM: UvrD-like DNA helicase, C terminal; PFAM: UvrD/REP helicase YP_001169144.1 PFAM: Nucleotidyl transferase YP_001169145.1 PFAM: aminoglycoside phosphotransferase YP_001169146.1 PFAM: protein of unknown function UPF0079 YP_001169147.1 SMART: PAS domain containing protein YP_001169148.1 PFAM: ATP-binding region, ATPase domain protein; histidine kinase A domain protein YP_001169149.1 PFAM: electron transport protein SCO1/SenC YP_001169150.1 PFAM: response regulator receiver YP_001169151.1 PFAM: transposase, IS4 family protein YP_001169152.1 PFAM: histone family protein nucleoid-structuring protein H-NS YP_001169153.1 PFAM: metal-dependent phosphohydrolase, HD sub domain YP_001169154.1 PFAM: glycosyl transferase, family 8 YP_001169155.1 catalyzes the formation of L-homocysteine from S-adenosyl-L-homocysteine YP_001169156.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate YP_001169160.1 PFAM: protein of unknown function DUF894, DitE; major facilitator superfamily MFS_1 YP_001169161.1 PFAM: transposase, IS4 family protein YP_001169162.1 produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine YP_001169163.1 PFAM: aminotransferase class-III YP_001169164.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001169165.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001169167.1 PFAM: protein of unknown function DUF72 YP_001169169.1 PFAM: alpha amylase, catalytic region; SMART: alpha amylase, catalytic sub domain YP_001169170.1 PFAM: diaminopimelate epimerase YP_001169171.1 TIGRFAM: RNA modification enzyme, MiaB family; MiaB-like tRNA modifying enzyme; PFAM: Radical SAM domain protein; Protein of unknown function UPF0004-like; SMART: Elongator protein 3/MiaB/NifB YP_001169172.1 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate YP_001169173.1 PFAM: peptidase M23B YP_001169174.1 TIGRFAM: carboxyl-terminal protease; PFAM: PDZ/DHR/GLGF domain protein; peptidase S41 YP_001169175.1 hydrolyzes diadenosine polyphosphate YP_001169176.1 TIGRFAM: FolC bifunctional protein; PFAM: cytoplasmic peptidoglycan synthetase domain protein; Mur ligase, middle domain protein YP_001169177.1 TIGRFAM: acetyl-CoA carboxylase, carboxyl transferase, beta subunit YP_001169180.1 PFAM: regulatory protein, LysR; LysR, substrate-binding YP_001169181.1 PFAM: OmpA/MotB domain protein YP_001169182.1 PFAM: GCN5-related N-acetyltransferase YP_001169183.1 PFAM: molybdopterin binding domain YP_001169184.1 TIGRFAM: methionine aminopeptidase, type I; PFAM: peptidase M24 YP_001169185.1 TIGRFAM: TonB family protein YP_001169186.1 PFAM: Biopolymer transport protein ExbD/TolR YP_001169187.1 PFAM: MotA/TolQ/ExbB proton channel YP_001169188.1 PFAM: short-chain dehydrogenase/reductase SDR; KR YP_001169189.1 PFAM: Enoyl-CoA hydratase/isomerase YP_001169190.1 PFAM: short-chain dehydrogenase/reductase SDR YP_001169192.1 PFAM: peptidase U62, modulator of DNA gyrase YP_001169193.1 PFAM: inositol monophosphatase YP_001169194.1 PFAM: regulatory protein, LysR; LysR, substrate-binding YP_001169195.1 TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; PFAM: Haloacid dehalogenase domain protein hydrolase YP_001169196.1 TIGRFAM: putative methyltransferase; PFAM: conserved hypothetical protein 95 YP_001169197.1 PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase YP_001169198.1 PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; Redoxin domain protein YP_001169199.1 TIGRFAM: methylmalonyl-CoA mutase, large subunit; PFAM: methylmalonyl-CoA mutase; cobalamin B12-binding domain protein YP_001169200.1 TIGRFAM: crotonyl-CoA reductase; PFAM: Alcohol dehydrogenase, zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein YP_001169201.1 SMART: AAA ATPase YP_001169202.1 PFAM: regulatory protein, AsnC/Lrp family YP_001169203.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors YP_001169204.1 PFAM: protein of unknown function DUF952 YP_001169205.1 PFAM: response regulator receiver YP_001169206.1 PFAM: transglutaminase domain protein; transglutaminase, N-terminal domain protein YP_001169207.1 PFAM: protein of unknown function DUF403; protein of unknown function DUF404; protein of unknown function DUF407 YP_001169208.1 PFAM: transglutaminase domain protein; transglutaminase, N-terminal domain protein YP_001169210.1 PFAM: protein of unknown function DUF214 YP_001169211.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001169212.1 PFAM: uncharacterised conserved protein UCP028101 YP_001169214.1 PFAM: protein of unknown function DUF1111 YP_001169215.1 TIGRFAM: bacterioferritin; PFAM: Ferritin, Dps family protein YP_001169219.1 PFAM: protein of unknown function DUF533 YP_001169220.1 PFAM: regulatory protein, IclR YP_001169221.1 PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase YP_001169222.1 catalyzes the formation of glyoxylate from (S)-ureidoglycolate YP_001169223.1 PFAM: protein of unknown function DUF861, cupin_3; Cupin 2, conserved barrel domain protein YP_001169224.1 PFAM: polysaccharide deacetylase YP_001169225.1 PFAM: Transthyretin YP_001169226.1 PFAM: antenna complex, alpha/beta subunit YP_001169227.1 PFAM: antenna complex, alpha/beta subunit YP_001169228.1 Converts isocitrate to alpha ketoglutarate YP_001169229.1 ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis YP_001169230.1 PFAM: AMP-dependent synthetase and ligase YP_001169231.1 PFAM: fumarylacetoacetate (FAA) hydrolase YP_001169232.1 PFAM: luciferase family protein YP_001169233.1 PFAM: protein of unknown function UPF0118 YP_001169234.1 PFAM: BLUF domain protein YP_001169236.1 PFAM: cobalamin (vitamin B12) biosynthesis CbiX protein YP_001169237.1 TIGRFAM: PAS sensor protein; PFAM: response regulator receiver; ATP-binding region, ATPase domain protein; histidine kinase A domain protein; Hpt domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein YP_001169238.1 PFAM: glutamine synthetase, catalytic region YP_001169239.1 PFAM: aminotransferase class-III YP_001169240.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway YP_001169241.1 TIGRFAM: phosphoribosylaminoimidazole carboxylase, catalytic subunit; PFAM: 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase YP_001169242.1 PFAM: protein of unknown function DUF465 YP_001169243.1 PFAM: heat shock protein Hsp20 YP_001169244.1 PFAM: protein of unknown function DUF1150 YP_001169245.1 TIGRFAM: Mg chelatase, subunit ChlI; PFAM: magnesium chelatase, ChlI subunit; ATPase associated with various cellular activities, AAA_5; SMART: AAA ATPase YP_001169246.1 PFAM: protein of unknown function DUF892 YP_001169247.1 TIGRFAM: oxidoreductase alpha (molybdopterin) subunit; PFAM: molybdopterin oxidoreductase; molydopterin dinucleotide-binding region YP_001169248.1 TIGRFAM: NAD+ synthetase; PFAM: NAD+ synthase; CinA domain protein YP_001169249.1 forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis YP_001169250.1 PFAM: Alcohol dehydrogenase, zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein YP_001169254.1 PFAM: phage integrase family protein YP_001169255.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis YP_001169256.1 TIGRFAM: phosphoribosylglycinamide formyltransferase; PFAM: formyl transferase domain protein YP_001169257.1 TIGRFAM: ribonuclease D; PFAM: HRDC domain protein; 3'-5' exonuclease YP_001169259.1 PFAM: Fe-S metabolism associated SufE YP_001169260.1 PFAM: protein of unknown function DUF427 YP_001169261.1 PFAM: creatinase; peptidase M24 YP_001169262.1 PFAM: von Willebrand factor, type A; Cobalt chelatase, CobT subunit YP_001169265.1 TIGRFAM: cobalt chelatase, pCobS small subunit; PFAM: ATPase associated with various cellular activities, AAA_5 YP_001169266.1 PFAM: heat shock protein DnaJ domain protein YP_001169267.1 PFAM: BolA family protein YP_001169268.1 catalyzes the formation of malate from glyoxylate and acetyl-CoA YP_001169269.1 PFAM: DNA photolyase domain protein YP_001169270.1 TIGRFAM: aminopeptidase N; PFAM: peptidase M1, membrane alanine aminopeptidase YP_001169271.1 PFAM: phospholipid/glycerol acyltransferase YP_001169272.1 catalyzes the formation of histidinol phosphate and 2-oxoglutarate from glutamate and imidazole acetol-phosphate YP_001169274.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_001169275.1 PFAM: Lytic transglycosylase, catalytic YP_001169276.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain YP_001169277.1 PFAM: regulatory protein, AsnC/Lrp family YP_001169278.1 PFAM: Orn/DAP/Arg decarboxylase 2 YP_001169280.1 TIGRFAM: citrate synthase I; PFAM: Citrate synthase YP_001169281.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_001169282.1 PFAM: ComEC/Rec2-related protein YP_001169283.1 Represses a number of genes involved in the response to DNA damage YP_001169284.1 TIGRFAM: molybdenum cofactor synthesis domain; PFAM: molybdopterin binding domain; MoeA domain protein, domain I and II; MoeA domain protein, domain IV YP_001169285.1 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis YP_001169286.1 involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water YP_001169287.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate YP_001169288.1 TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity YP_001169289.1 PFAM: protein of unknown function DUF610, YibQ YP_001169290.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine YP_001169292.1 PFAM: AsmA family protein YP_001169293.1 PFAM: GcrA cell cycle regulator YP_001169294.1 DapATase; functions in arginine biosynthetic pathway; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine YP_001169295.1 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation YP_001169297.1 TIGRFAM: 3-oxoacid CoA-transferase, A subunit; PFAM: coenzyme A transferase YP_001169298.1 TIGRFAM: 3-oxoacid CoA-transferase, B subunit; PFAM: coenzyme A transferase YP_001169300.1 TIGRFAM: ATP-dependent helicase HrpB; PFAM: helicase domain protein; helicase-associated domain protein; DEAD/DEAH box helicase domain protein; Helicase ATP-dependent, C-terminal domain protein; SMART: DEAD-like helicases-like YP_001169302.1 functions in transport of arginine/ornithine; inner membrane ATPase that cleaves ATP and phosphorylates two periplasmic proteins that function as two distinct transport systems, the AO (arginine and ornithine) and LAO (lysine, arginine, and ornithine) periplasmic binding proteins YP_001169303.1 required for 70S ribosome assembly YP_001169305.1 PFAM: protein of unknown function DUF461 YP_001169307.1 binds to the ribosome on the universally-conserved alpha-sarcin loop YP_001169308.1 PFAM: Entericidin EcnAB YP_001169310.1 PFAM: ornithine cyclodeaminase/mu-crystallin; Shikimate/quinate 5-dehydrogenase YP_001169311.1 PFAM: protein of unknown function DUF188 YP_001169312.1 PFAM: putative esterase YP_001169313.1 PFAM: Auxin Efflux Carrier YP_001169315.1 PFAM: regulatory protein, TetR YP_001169316.1 TIGRFAM: exodeoxyribonuclease III Xth; PFAM: Endonuclease/exonuclease/phosphatase YP_001169317.1 PFAM: response regulator receiver; transcriptional regulator domain protein YP_001169318.1 PFAM: GTP cyclohydrolase II YP_001169320.1 PFAM: alanine racemase domain protein YP_001169321.1 PFAM: sulfotransferase; TPR repeat-containing protein; Tetratricopeptide TPR_4; Tetratricopeptide TPR_2 repeat protein; SMART: Tetratricopeptide domain protein YP_001169324.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase YP_001169326.1 PFAM: DNA polymerase III, delta YP_001169328.1 PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; HI0933 family protein; FAD dependent oxidoreductase; FAD-dependent pyridine nucleotide-disulphide oxidoreductase YP_001169334.1 catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis YP_001169338.1 PFAM: Aldose 1-epimerase YP_001169351.1 PFAM: HpcH/HpaI aldolase YP_001169352.1 PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding YP_001169353.1 PFAM: Dimethylmenaquinone methyltransferase YP_001169361.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001169362.1 PFAM: Asp/Glu racemase YP_001169363.1 PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit YP_001169364.1 catalyzes the formation of 2-oxobutanoate from L-threonine; involved in ectoine utilization YP_001169365.1 putative cyclodeaminase YP_001169374.1 involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans YP_001169376.1 PFAM: Positive regulator of sigma(E), RseC/MucC YP_001169377.1 PFAM: ferredoxin YP_001169382.1 PFAM: Respiratory-chain NADH dehydrogenase domain, 51 kDa subunit YP_001169383.1 TIGRFAM: electron transport complex, RnfABCDGE type, D subunit; PFAM: NQR2 and RnfD family protein YP_001169384.1 TIGRFAM: electron transport complex, RnfABCDGE type, G subunit; PFAM: FMN-binding domain protein YP_001169385.1 PFAM: RnfA-Nqr electron transport subunit YP_001169386.1 in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase YP_001169393.1 PFAM: molybdopterin dehydrogenase, FAD-binding YP_001169394.1 PFAM: aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead YP_001169402.1 Modulates the activities of several enzymes which are inactive in their acetylated form YP_001169403.1 PFAM: ABC-2 type transporter YP_001169406.1 PFAM: NapC/NirT cytochrome c domain protein YP_001169407.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein YP_001169409.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA YP_001169411.1 periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC YP_001169415.1 TIGRFAM: bacterioferritin; PFAM: Rubrerythrin; Ferritin, Dps family protein YP_001169421.1 PFAM: low molecular weight phosphotyrosine protein phosphatase YP_001169439.1 catalyzes the formation of selenophosphate from selenide and ATP YP_001169442.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001169444.1 PFAM: short-chain dehydrogenase/reductase SDR YP_001169445.1 PFAM: Malate/L-lactate dehydrogenase YP_001169447.1 PFAM: Tripartite ATP-independent periplasmic transporter, DctQ component YP_001169451.1 TIGRFAM: phosphonate ABC transporter, inner membrane subunit; PFAM: binding-protein-dependent transport systems inner membrane component YP_001169452.1 TIGRFAM: phosphonate ABC transporter, ATPase subunit; PFAM: ABC transporter related; SMART: AAA ATPase YP_001169458.1 PFAM: inner-membrane translocator YP_001169459.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001169460.1 PFAM: ABC transporter related YP_001169462.1 PFAM: Acetamidase/Formamidase YP_001169465.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001169471.1 part of the UgpABCE glycerol-3-phosphate uptake system YP_001169479.1 PFAM: ABC transporter related YP_001169484.1 PFAM: KDPG and KHG aldolase YP_001169485.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-galactonate 6-phosphate; functions in galactonate metabolism YP_001169486.1 PFAM: response regulator receiver YP_001169494.1 PFAM: Haem peroxidase YP_001169500.1 acts as a promotor non-specific transcription repressor YP_001169507.1 reduces nitrous oxide to nitrogen YP_001169510.1 PFAM: NosL family protein YP_001169517.1 PFAM: transport system permease protein YP_001169518.1 PFAM: transport system permease protein YP_001169519.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001169525.1 PFAM: regulatory protein GntR, HTH; GntR domain protein YP_001169526.1 PFAM: TRAP dicarboxylate transporter- DctP subunit YP_001169535.1 TIGRFAM: ribokinase; PFAM: PfkB domain protein YP_001169537.1 PFAM: inner-membrane translocator YP_001169543.1 YghU; B2989; one of eight putative glutathione transferase proteins from E. coli YP_001169544.1 TIGRFAM: molybdenum ABC transporter, periplasmic molybdate-binding protein; PFAM: extracellular solute-binding protein, family 1 YP_001169547.1 TIGRFAM: hydrogenase assembly chaperone hypC/hupF; PFAM: hydrogenase expression/formation protein (HUPF/HYPC) YP_001169549.1 TIGRFAM: hydrogenase accessory protein HypB; PFAM: cobalamin synthesis protein, P47K YP_001169550.1 PFAM: hydrogenase expression/synthesis, HypA YP_001169552.1 PFAM: Rubredoxin-type Fe(Cys)4 protein YP_001169553.1 PFAM: HupH hydrogenase expression protein YP_001169554.1 PFAM: hydrogenase-1 expression HyaE YP_001169562.1 PFAM: nickel-dependent hydrogenase, large subunit YP_001169563.1 PFAM: NADH ubiquinone oxidoreductase, 20 kDa subunit YP_001169575.1 PFAM: transposase IS116/IS110/IS902 family protein YP_001169581.1 PFAM: glycosyl transferase, group 1 YP_001169582.1 PFAM: O-antigen polymerase YP_001169583.1 PFAM: polysaccharide deacetylase YP_001169593.1 PFAM: protein of unknown function DUF849 YP_001169603.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001169605.1 PFAM: protein kinase; SMART: serine/threonine protein kinase YP_001169618.1 catalyzes the ATP-dependent transport of cobalt YP_001169627.1 PFAM: CobB/CobQ domain protein glutamine amidotransferase YP_001169641.1 PFAM: UspA domain protein YP_001169646.1 TIGRFAM: efflux transporter, RND family, MFP subunit YP_001169647.1 PFAM: AbgT putative transporter YP_001169666.1 PFAM: ATP-binding region, ATPase domain protein YP_001169673.1 PFAM: IstB domain protein ATP-binding protein; SMART: AAA ATPase YP_001169676.1 PFAM: IstB domain protein ATP-binding protein YP_001169685.1 PFAM: HWE histidine kinase YP_001169691.1 PFAM: IS66 Orf2 family protein YP_001169705.1 PFAM: transposase, IS4 family protein YP_001169709.1 PFAM: EcoEI R, C-terminal domain protein YP_001169712.1 PFAM: Exonuclease, RNase T and DNA polymerase III; SMART: Exonuclease YP_001169723.1 PFAM: ABC transporter related YP_001169724.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001169725.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001169729.1 PFAM: transposase IS3/IS911 family protein YP_001169735.1 PFAM: IstB domain protein ATP-binding protein YP_001169740.1 catalyzes the formation of malonyl-CoA from malonate and CoA YP_001169742.1 PFAM: Tripartite ATP-independent periplasmic transporter, DctQ component YP_001169760.1 PFAM: D-tagatose-bisphosphate aldolase class II accessory protein AgaZ YP_001169764.1 PFAM: glutathionylspermidine synthase YP_001169794.1 subunit G of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_001169795.1 subunit F of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in S. meliloti it is known to be involved specifically with K+ transport YP_001169796.1 subunit E of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_001169797.1 subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone YP_001169798.1 subunit C of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_001169799.1 subunit A of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in S. meliloti it is known to be involved with K+ YP_001169803.1 PFAM: protein of unknown function DUF1428 YP_001169807.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001169813.1 tryptophan indole-lyase; catalyzes the formation of indole and pyruvate from tryptophan YP_001169817.1 PFAM: protein of unknown function DUF1602 YP_001169820.1 PFAM: Xylose isomerase domain protein TIM barrel YP_001169821.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001169822.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001169827.1 PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase YP_001169829.1 catalyzes the selenophosphate-dependent transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA YP_001169830.1 PFAM: dihydropteroate synthase, DHPS YP_001169835.1 PFAM: Alcohol dehydrogenase, zinc-binding domain protein YP_001169841.1 PFAM: cytochrome c oxidase, subunit I YP_001169842.1 PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70, region 4 type 2 YP_001169844.1 Bacteria have multiple sigma factors which are active under specific conditions; the sigma factor binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; possibly involved in prevention of copper toxicity YP_001169848.1 PFAM: protein of unknown function DUF485 YP_001169853.1 PFAM: histidine kinase, HAMP region domain protein; histidine kinase A domain protein YP_001169857.1 PFAM: aminotransferase class-III YP_001169867.1 PFAM: transposase, IS4 family protein YP_001169869.1 PFAM: IS66 Orf2 family protein YP_001169881.1 PFAM: glycoside hydrolase, family 24 YP_001169884.1 TIGRFAM: putative phage cell wall peptidase, NlpC/P60 family; PFAM: NLP/P60 protein YP_001169887.1 PFAM: IS66 Orf2 family protein YP_001169891.1 PFAM: IS66 Orf2 family protein YP_001169893.1 PFAM: transposase IS66 YP_001169901.1 PFAM: PglZ domain YP_001169916.1 PFAM: helicase domain protein YP_001169925.1 TIGRFAM: sulfate ABC transporter, periplasmic sulfate-binding protein YP_001169931.1 PFAM: transposase IS66 YP_001169937.1 PFAM: PhnA protein-like YP_001169950.1 PFAM: Osmosensitive K+ channel His kinase sensor YP_001169960.1 PFAM: ribosomal protein L27; ribosomal protein L21 YP_001169962.1 involved in the peptidyltransferase reaction during translation YP_001169964.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication YP_001169965.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis YP_001169966.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway YP_001169969.1 PFAM: phospholipid/glycerol acyltransferase YP_001169974.1 PFAM: peptidase M32, carboxypeptidase Taq metallopeptidase YP_001169978.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_001170020.1 PFAM: Alcohol dehydrogenase, zinc-binding domain protein YP_001170024.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001170030.1 PFAM: Protein of unknown function UPF0004-like YP_001170032.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A) YP_001170037.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase YP_001170039.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine YP_001170040.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis YP_001170041.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP YP_001170042.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins YP_001170043.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control YP_001170045.1 catalyzes the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)-anthranilate in tryptophan biosynthesis YP_001170047.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate YP_001170052.1 PFAM: short-chain dehydrogenase/reductase SDR; KR YP_001170061.1 PFAM: inner-membrane translocator YP_001170063.1 PFAM: protein of unknown function DUF849 YP_001170069.1 PFAM: aldehyde dehydrogenase YP_001170076.1 with SoxZ catalyzes the oxidation of sulfur compounds YP_001170078.1 PFAM: cytochrome c biogenesis protein, transmembrane region YP_001170084.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis YP_001170087.1 PFAM: BCCT transporter YP_001170091.1 PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase YP_001170095.1 catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP YP_001170098.1 TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase YP_001170102.1 PFAM: inner-membrane translocator YP_001170104.1 PFAM: protein of unknown function DUF182 YP_001170106.1 PFAM: molybdopterin dehydrogenase, FAD-binding; CO dehydrogenase flavoprotein domain protein YP_001170108.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase YP_001170110.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG YP_001170111.1 May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine YP_001170112.1 short form of enzyme; requires HisZ for function; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms heteromultimer of HisG and HisZ YP_001170125.1 PFAM: ABC transporter related; Oligopeptide/dipeptide ABC transporter, C-terminal domain protein; SMART: AAA ATPase YP_001170129.1 PFAM: response regulator receiver; transcriptional regulator domain protein YP_001170149.1 periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC YP_001170158.1 PFAM: nitroreductase YP_001170175.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase YP_001170177.1 class II aldolase; catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle, glycolysis and gluconeogenesis YP_001170178.1 catalyzes the carboxylation of D-ribulose 1,5-bisphosphate in carbon dioxide fixation YP_001170187.1 TIGRFAM: autotransporter-associated beta strand repeat protein YP_001170189.1 TIGRFAM: autotransporter-associated beta strand repeat protein YP_001170192.1 TIGRFAM: deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; PFAM: transposase, IS4 family protein; deoxyUTP pyrophosphatase YP_001170210.1 PFAM: protein of unknown function DUF214 YP_001170211.1 PFAM: protein of unknown function DUF323 YP_001170220.1 type III RuBisCO; involved in carbon fixation YP_001170236.1 TIGRFAM: sulfate ABC transporter, periplasmic sulfate-binding protein YP_001170245.1 PFAM: polysaccharide export protein YP_001170246.1 PFAM: low molecular weight phosphotyrosine protein phosphatase YP_001170252.1 PFAM: NAD-dependent epimerase/dehydratase; UDP-glucose/GDP-mannose dehydrogenase; 3-beta hydroxysteroid dehydrogenase/isomerase; Male sterility C-terminal domain YP_001170253.1 PFAM: lipopolysaccharide biosynthesis protein YP_001170263.1 PFAM: ATP-binding region, ATPase domain protein YP_001170268.1 PFAM: sodium/glutamate symporter YP_001170270.1 TIGRFAM: prevent-host-death family protein; PFAM: protein of unknown function DUF172 YP_001170307.1 PFAM: transposase, IS4 family protein YP_001170314.1 PFAM: histidine kinase, dimerisation/phosphoacceptor YP_001170316.1 PFAM: 6-phosphogluconate dehydrogenase domain protein YP_001170330.1 PFAM: PAS fold-4 domain protein YP_001170334.1 PFAM: regulatory protein, LuxR YP_001170373.1 PFAM: HipA domain protein YP_001170395.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis YP_001170403.1 specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport YP_001170405.1 PFAM: SH3, type 3 domain protein YP_001170409.1 Acts on the hydroxyl group at position 7 of the steroid frame YP_001170413.1 PFAM: periplasmic binding protein YP_001170416.1 PFAM: transport system permease protein YP_001170420.1 PFAM: regulatory protein GntR, HTH; GntR domain protein YP_001170427.1 Regulates the synthesis of nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, and GTP for protein elongation YP_001170431.1 PFAM: EAL domain protein YP_001170452.1 PFAM: transposase IS66 YP_001170461.1 PFAM: TOBE domain protein YP_001170477.1 PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes YP_001170481.1 PFAM: NLPA lipoprotein YP_001170484.1 responsible for the amidation of carboxylic groups at position A and C of cobyrinic acid or hydrogenobrynic acid YP_001170509.1 PFAM: Relaxase/mobilization nuclease family protein YP_001170511.1 PFAM: N-6 DNA methylase YP_001170518.1 PFAM: TRAG family protein YP_001170519.1 PFAM: type II secretion system protein E YP_001170520.1 PFAM: conjugation TrbI family protein YP_001170521.1 PFAM: Conjugal transfer protein TrbG/VirB9/CagX YP_001170522.1 PFAM: VirB8 family protein YP_001170523.1 PFAM: TrbL/VirB6 plasmid conjugal transfer protein YP_001170525.1 PFAM: type IV secretion system family protein YP_001170526.1 TIGRFAM: type IV secretion/conjugal transfer ATPase, VirB4 family; PFAM: CagE, TrbE, VirB component of type IV transporter system YP_001170527.1 PFAM: type IV secretory pathway, VirB3 family protein YP_001170529.1 PFAM: Lytic transglycosylase, catalytic YP_001170532.1 PFAM: Resolvase, N-terminal domain; Resolvase helix-turn-helix domain protein YP_001170535.1 PFAM: histone family protein nucleoid-structuring protein H-NS YP_001170536.1 PFAM: protein of unknown function DUF932 YP_001170537.1 PFAM: Cobyrinic acid a,c-diamide synthase YP_001170538.1 TIGRFAM: parB-like partition protein; PFAM: ParB domain protein nuclease; KorB domain protein YP_001170539.1 PFAM: SMF family protein YP_001170540.1 PFAM: transposase IS3/IS911 family protein YP_001170541.1 PFAM: Integrase, catalytic region YP_001170542.1 PFAM: Resolvase, N-terminal domain YP_001170544.1 PFAM: plasmid pRiA4b ORF-3 family protein YP_001170545.1 PFAM: transposase IS66 YP_001170546.1 PFAM: IS66 Orf2 family protein YP_001170547.1 PFAM: transposase IS3/IS911 family protein