-- dump date 20140620_025429 -- class Genbank::misc_feature -- table misc_feature_note -- id note 685727000001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685727000002 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 685727000003 Walker A motif; other site 685727000004 ATP binding site [chemical binding]; other site 685727000005 Walker B motif; other site 685727000006 arginine finger; other site 685727000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 685727000008 DnaA box-binding interface [nucleotide binding]; other site 685727000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 685727000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 685727000011 putative DNA binding surface [nucleotide binding]; other site 685727000012 dimer interface [polypeptide binding]; other site 685727000013 beta-clamp/clamp loader binding surface; other site 685727000014 beta-clamp/translesion DNA polymerase binding surface; other site 685727000015 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 685727000016 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 685727000017 recombination protein F; Reviewed; Region: recF; PRK00064 685727000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 685727000019 Walker A/P-loop; other site 685727000020 ATP binding site [chemical binding]; other site 685727000021 Q-loop/lid; other site 685727000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685727000023 ABC transporter signature motif; other site 685727000024 Walker B; other site 685727000025 D-loop; other site 685727000026 H-loop/switch region; other site 685727000027 hypothetical protein; Provisional; Region: PRK03195 685727000028 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 685727000029 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 685727000030 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 685727000031 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 685727000032 FMN-binding pocket [chemical binding]; other site 685727000033 flavin binding motif; other site 685727000034 phosphate binding motif [ion binding]; other site 685727000035 beta-alpha-beta structure motif; other site 685727000036 NAD binding pocket [chemical binding]; other site 685727000037 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 685727000038 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 685727000039 catalytic loop [active] 685727000040 iron binding site [ion binding]; other site 685727000041 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 685727000042 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 685727000043 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685727000044 ATP binding site [chemical binding]; other site 685727000045 Mg2+ binding site [ion binding]; other site 685727000046 G-X-G motif; other site 685727000047 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 685727000048 anchoring element; other site 685727000049 dimer interface [polypeptide binding]; other site 685727000050 ATP binding site [chemical binding]; other site 685727000051 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 685727000052 active site 685727000053 putative metal-binding site [ion binding]; other site 685727000054 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 685727000055 DNA gyrase subunit A; Validated; Region: PRK05560 685727000056 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 685727000057 CAP-like domain; other site 685727000058 active site 685727000059 primary dimer interface [polypeptide binding]; other site 685727000060 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 685727000061 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 685727000062 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 685727000063 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 685727000064 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 685727000065 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 685727000066 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 685727000067 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 685727000068 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727000069 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727000070 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727000071 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727000072 Secretory lipase; Region: LIP; pfam03583 685727000073 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 685727000074 active site 685727000075 B-box zinc finger; Region: zf-B_box; pfam00643 685727000076 Rhomboid family; Region: Rhomboid; pfam01694 685727000077 putative septation inhibitor protein; Reviewed; Region: PRK00159 685727000078 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 685727000079 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 685727000080 Glutamine amidotransferase class-I; Region: GATase; pfam00117 685727000081 glutamine binding [chemical binding]; other site 685727000082 catalytic triad [active] 685727000083 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 685727000084 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 685727000085 active site 685727000086 ATP binding site [chemical binding]; other site 685727000087 substrate binding site [chemical binding]; other site 685727000088 activation loop (A-loop); other site 685727000089 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 685727000090 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 685727000091 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 685727000092 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 685727000093 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 685727000094 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 685727000095 Catalytic domain of Protein Kinases; Region: PKc; cd00180 685727000096 active site 685727000097 ATP binding site [chemical binding]; other site 685727000098 substrate binding site [chemical binding]; other site 685727000099 activation loop (A-loop); other site 685727000100 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 685727000101 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 685727000102 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 685727000103 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 685727000104 active site 685727000105 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 685727000106 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 685727000107 phosphopeptide binding site; other site 685727000108 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 685727000109 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 685727000110 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 685727000111 phosphopeptide binding site; other site 685727000112 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 685727000113 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727000114 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727000115 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 685727000116 homotrimer interaction site [polypeptide binding]; other site 685727000117 putative active site [active] 685727000118 Predicted transcriptional regulators [Transcription]; Region: COG1733 685727000119 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 685727000120 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 685727000121 Bacterial transcriptional regulator; Region: IclR; pfam01614 685727000122 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 685727000123 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 685727000124 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 685727000125 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 685727000126 homotrimer interaction site [polypeptide binding]; other site 685727000127 putative active site [active] 685727000128 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 685727000129 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 685727000130 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 685727000131 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 685727000132 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727000133 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 685727000134 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 685727000135 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 685727000136 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 685727000137 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 685727000138 active site 685727000139 dimer interface [polypeptide binding]; other site 685727000140 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 685727000141 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 685727000142 active site 685727000143 FMN binding site [chemical binding]; other site 685727000144 substrate binding site [chemical binding]; other site 685727000145 3Fe-4S cluster binding site [ion binding]; other site 685727000146 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 685727000147 domain interface; other site 685727000148 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 685727000149 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 685727000150 Cutinase; Region: Cutinase; pfam01083 685727000151 Protein of unknown function (DUF732); Region: DUF732; pfam05305 685727000152 short chain dehydrogenase; Validated; Region: PRK06182 685727000153 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 685727000154 NADP binding site [chemical binding]; other site 685727000155 active site 685727000156 steroid binding site; other site 685727000157 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 685727000158 FAD binding domain; Region: FAD_binding_2; pfam00890 685727000159 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727000160 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727000161 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 685727000162 Uncharacterized conserved protein [Function unknown]; Region: COG1359 685727000163 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 685727000164 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 685727000165 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 685727000166 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 685727000167 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 685727000168 dimer interface [polypeptide binding]; other site 685727000169 putative anticodon binding site; other site 685727000170 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 685727000171 motif 1; other site 685727000172 dimer interface [polypeptide binding]; other site 685727000173 active site 685727000174 motif 2; other site 685727000175 motif 3; other site 685727000176 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 685727000177 RNA binding surface [nucleotide binding]; other site 685727000178 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 685727000179 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 685727000180 Moco binding site; other site 685727000181 metal coordination site [ion binding]; other site 685727000182 Transcriptional regulators [Transcription]; Region: FadR; COG2186 685727000183 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 685727000184 DNA-binding site [nucleotide binding]; DNA binding site 685727000185 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 685727000186 additional locus_tag=REQ_00640; D-lactate dehydrogenase 685727000187 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 685727000188 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 685727000189 substrate binding site [chemical binding]; other site 685727000190 oxyanion hole (OAH) forming residues; other site 685727000191 trimer interface [polypeptide binding]; other site 685727000192 acyl-CoA synthetase; Validated; Region: PRK07787 685727000193 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 685727000194 acyl-activating enzyme (AAE) consensus motif; other site 685727000195 AMP binding site [chemical binding]; other site 685727000196 active site 685727000197 CoA binding site [chemical binding]; other site 685727000198 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 685727000199 Transcriptional regulator [Transcription]; Region: IclR; COG1414 685727000200 Bacterial transcriptional regulator; Region: IclR; pfam01614 685727000201 MarR family; Region: MarR_2; cl17246 685727000202 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 685727000203 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 685727000204 iron-sulfur cluster [ion binding]; other site 685727000205 [2Fe-2S] cluster binding site [ion binding]; other site 685727000206 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 685727000207 hydrophobic ligand binding site; other site 685727000208 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 685727000209 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 685727000210 catalytic loop [active] 685727000211 iron binding site [ion binding]; other site 685727000212 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 685727000213 FAD binding pocket [chemical binding]; other site 685727000214 conserved FAD binding motif [chemical binding]; other site 685727000215 phosphate binding motif [ion binding]; other site 685727000216 beta-alpha-beta structure motif; other site 685727000217 NAD binding pocket [chemical binding]; other site 685727000218 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 685727000219 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 685727000220 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 685727000221 active site 685727000222 Fe binding site [ion binding]; other site 685727000223 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 685727000224 Amidase; Region: Amidase; cl11426 685727000225 M20 Peptidases, Poly(aspartic acid) hydrolase-like proteins; Region: M20_PAAh_like; cd03896 685727000226 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 685727000227 putative metal binding site [ion binding]; other site 685727000228 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 685727000229 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 685727000230 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 685727000231 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 685727000232 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 685727000233 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 685727000234 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 685727000235 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 685727000236 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727000237 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727000238 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 685727000239 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 685727000240 Phosphotransferase enzyme family; Region: APH; pfam01636 685727000241 putative active site [active] 685727000242 putative substrate binding site [chemical binding]; other site 685727000243 ATP binding site [chemical binding]; other site 685727000244 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 685727000245 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 685727000246 Coenzyme A transferase; Region: CoA_trans; cl17247 685727000247 Nitronate monooxygenase; Region: NMO; pfam03060 685727000248 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 685727000249 FMN binding site [chemical binding]; other site 685727000250 substrate binding site [chemical binding]; other site 685727000251 putative catalytic residue [active] 685727000252 short chain dehydrogenase; Provisional; Region: PRK07791 685727000253 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727000254 NAD(P) binding site [chemical binding]; other site 685727000255 active site 685727000256 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 685727000257 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 685727000258 active site 2 [active] 685727000259 active site 1 [active] 685727000260 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 685727000261 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 685727000262 NAD(P) binding site [chemical binding]; other site 685727000263 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 685727000264 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 685727000265 active site 685727000266 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 685727000267 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 685727000268 acyl-activating enzyme (AAE) consensus motif; other site 685727000269 AMP binding site [chemical binding]; other site 685727000270 active site 685727000271 CoA binding site [chemical binding]; other site 685727000272 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 685727000273 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 685727000274 acyl-activating enzyme (AAE) consensus motif; other site 685727000275 putative AMP binding site [chemical binding]; other site 685727000276 putative active site [active] 685727000277 putative CoA binding site [chemical binding]; other site 685727000278 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 685727000279 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 685727000280 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 685727000281 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 685727000282 Walker A/P-loop; other site 685727000283 ATP binding site [chemical binding]; other site 685727000284 Q-loop/lid; other site 685727000285 ABC transporter signature motif; other site 685727000286 Walker B; other site 685727000287 D-loop; other site 685727000288 H-loop/switch region; other site 685727000289 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727000290 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727000291 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 685727000292 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 685727000293 NAD(P) binding site [chemical binding]; other site 685727000294 catalytic residues [active] 685727000295 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 685727000296 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685727000297 active site 685727000298 phosphorylation site [posttranslational modification] 685727000299 intermolecular recognition site; other site 685727000300 dimerization interface [polypeptide binding]; other site 685727000301 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 685727000302 DNA binding residues [nucleotide binding] 685727000303 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 685727000304 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 685727000305 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 685727000306 substrate binding pocket [chemical binding]; other site 685727000307 catalytic triad [active] 685727000308 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 685727000309 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727000310 putative substrate translocation pore; other site 685727000311 SPW repeat; Region: SPW; pfam03779 685727000312 SPW repeat; Region: SPW; pfam03779 685727000313 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 685727000314 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 685727000315 NAD(P) binding site [chemical binding]; other site 685727000316 catalytic residues [active] 685727000317 metabolite-proton symporter; Region: 2A0106; TIGR00883 685727000318 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727000319 putative substrate translocation pore; other site 685727000320 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 685727000321 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 685727000322 Transcriptional regulator [Transcription]; Region: LysR; COG0583 685727000323 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685727000324 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 685727000325 dimerization interface [polypeptide binding]; other site 685727000326 classical (c) SDRs; Region: SDR_c; cd05233 685727000327 NAD(P) binding site [chemical binding]; other site 685727000328 active site 685727000329 Copper resistance protein D; Region: CopD; cl00563 685727000330 CopC domain; Region: CopC; pfam04234 685727000331 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 685727000332 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 685727000333 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 685727000334 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 685727000335 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727000336 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 685727000337 NAD(P) binding site [chemical binding]; other site 685727000338 active site 685727000339 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 685727000340 homotrimer interaction site [polypeptide binding]; other site 685727000341 putative active site [active] 685727000342 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 685727000343 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 685727000344 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 685727000345 TIGR03086 family protein; Region: TIGR03086 685727000346 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 685727000347 Predicted transcriptional regulators [Transcription]; Region: COG1695 685727000348 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 685727000349 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 685727000350 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685727000351 active site 685727000352 phosphorylation site [posttranslational modification] 685727000353 intermolecular recognition site; other site 685727000354 dimerization interface [polypeptide binding]; other site 685727000355 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 685727000356 dimerization interface [polypeptide binding]; other site 685727000357 DNA binding residues [nucleotide binding] 685727000358 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 685727000359 Histidine kinase; Region: HisKA_3; pfam07730 685727000360 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685727000361 ATP binding site [chemical binding]; other site 685727000362 Mg2+ binding site [ion binding]; other site 685727000363 G-X-G motif; other site 685727000364 Domain of unknown function (DUF336); Region: DUF336; pfam03928 685727000365 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 685727000366 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 685727000367 amidase; Provisional; Region: PRK07869 685727000368 Amidase; Region: Amidase; cl11426 685727000369 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727000370 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727000371 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 685727000372 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 685727000373 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 685727000374 active site 685727000375 Fe binding site [ion binding]; other site 685727000376 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 685727000377 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 685727000378 active site 685727000379 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 685727000380 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 685727000381 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 685727000382 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 685727000383 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 685727000384 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 685727000385 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 685727000386 dimer interface [polypeptide binding]; other site 685727000387 putative radical transfer pathway; other site 685727000388 diiron center [ion binding]; other site 685727000389 tyrosyl radical; other site 685727000390 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 685727000391 heme-binding site [chemical binding]; other site 685727000392 Predicted membrane protein [Function unknown]; Region: COG2119 685727000393 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 685727000394 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 685727000395 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 685727000396 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 685727000397 putative metal binding residues [ion binding]; other site 685727000398 signature motif; other site 685727000399 dimer interface [polypeptide binding]; other site 685727000400 active site 685727000401 polyP binding site; other site 685727000402 substrate binding site [chemical binding]; other site 685727000403 acceptor-phosphate pocket; other site 685727000404 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 685727000405 Spore coat assembly protein [Cell envelope biogenesis, outer membrane]; Region: CotH; COG5337 685727000406 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 685727000407 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 685727000408 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 685727000409 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 685727000410 methionine sulfoxide reductase A; Provisional; Region: PRK00058 685727000411 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 685727000412 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727000413 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 685727000414 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 685727000415 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 685727000416 active site residue [active] 685727000417 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 685727000418 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 685727000419 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 685727000420 active site 685727000421 catalytic site [active] 685727000422 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 685727000423 Ferritin-like domain; Region: Ferritin; pfam00210 685727000424 ferroxidase diiron center [ion binding]; other site 685727000425 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 685727000426 Ferritin-like domain; Region: Ferritin; pfam00210 685727000427 ferroxidase diiron center [ion binding]; other site 685727000428 Transcriptional regulator [Transcription]; Region: LytR; COG1316 685727000429 CAAX protease self-immunity; Region: Abi; pfam02517 685727000430 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 685727000431 Beta-lactamase; Region: Beta-lactamase; pfam00144 685727000432 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 685727000433 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 685727000434 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 685727000435 prephenate dehydratase; Provisional; Region: PRK11898 685727000436 Prephenate dehydratase; Region: PDT; pfam00800 685727000437 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 685727000438 putative L-Phe binding site [chemical binding]; other site 685727000439 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 685727000440 catalytic core [active] 685727000441 EspG family; Region: ESX-1_EspG; pfam14011 685727000442 PPE family; Region: PPE; pfam00823 685727000443 PE family; Region: PE; pfam00934 685727000444 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 685727000445 Septum formation; Region: Septum_form; pfam13845 685727000446 Septum formation; Region: Septum_form; pfam13845 685727000447 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 685727000448 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 685727000449 seryl-tRNA synthetase; Provisional; Region: PRK05431 685727000450 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 685727000451 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 685727000452 dimer interface [polypeptide binding]; other site 685727000453 active site 685727000454 motif 1; other site 685727000455 motif 2; other site 685727000456 motif 3; other site 685727000457 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 685727000458 CoenzymeA binding site [chemical binding]; other site 685727000459 subunit interaction site [polypeptide binding]; other site 685727000460 PHB binding site; other site 685727000461 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 685727000462 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 685727000463 putative acyl-acceptor binding pocket; other site 685727000464 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685727000465 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 685727000466 active site 685727000467 motif I; other site 685727000468 motif II; other site 685727000469 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 685727000470 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 685727000471 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 685727000472 amidase catalytic site [active] 685727000473 Zn binding residues [ion binding]; other site 685727000474 substrate binding site [chemical binding]; other site 685727000475 Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385 685727000476 Stage II sporulation protein; Region: SpoIID; pfam08486 685727000477 LGFP repeat; Region: LGFP; pfam08310 685727000478 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 685727000479 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 685727000480 DNA binding residues [nucleotide binding] 685727000481 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 685727000482 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 685727000483 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 685727000484 UDP-galactopyranose mutase; Region: GLF; pfam03275 685727000485 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 685727000486 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 685727000487 active site 685727000488 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 685727000489 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 685727000490 active site 685727000491 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 685727000492 Predicted esterase [General function prediction only]; Region: COG0627 685727000493 Putative esterase; Region: Esterase; pfam00756 685727000494 S-formylglutathione hydrolase; Region: PLN02442 685727000495 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 685727000496 LGFP repeat; Region: LGFP; pfam08310 685727000497 LGFP repeat; Region: LGFP; pfam08310 685727000498 LGFP repeat; Region: LGFP; pfam08310 685727000499 Protein of unknown function (DUF732); Region: DUF732; pfam05305 685727000500 Cutinase; Region: Cutinase; pfam01083 685727000501 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 685727000502 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 685727000503 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 685727000504 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 685727000505 acyl-activating enzyme (AAE) consensus motif; other site 685727000506 active site 685727000507 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 685727000508 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 685727000509 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 685727000510 active site 685727000511 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 685727000512 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 685727000513 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 685727000514 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 685727000515 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 685727000516 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 685727000517 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 685727000518 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 685727000519 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 685727000520 hydrophobic ligand binding site; other site 685727000521 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 685727000522 dimerization interface [polypeptide binding]; other site 685727000523 putative DNA binding site [nucleotide binding]; other site 685727000524 putative Zn2+ binding site [ion binding]; other site 685727000525 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 685727000526 active site 685727000527 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 685727000528 FAD binding domain; Region: FAD_binding_4; pfam01565 685727000529 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 685727000530 Cysteine-rich domain; Region: CCG; pfam02754 685727000531 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 685727000532 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 685727000533 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 685727000534 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 685727000535 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 685727000536 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 685727000537 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727000538 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727000539 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 685727000540 active site 685727000541 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 685727000542 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 685727000543 Active Sites [active] 685727000544 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 685727000545 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 685727000546 CysD dimerization site [polypeptide binding]; other site 685727000547 G1 box; other site 685727000548 putative GEF interaction site [polypeptide binding]; other site 685727000549 GTP/Mg2+ binding site [chemical binding]; other site 685727000550 Switch I region; other site 685727000551 G2 box; other site 685727000552 G3 box; other site 685727000553 Switch II region; other site 685727000554 G4 box; other site 685727000555 G5 box; other site 685727000556 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 685727000557 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 685727000558 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 685727000559 ligand-binding site [chemical binding]; other site 685727000560 SnoaL-like domain; Region: SnoaL_2; pfam12680 685727000561 short chain dehydrogenase; Provisional; Region: PRK07890 685727000562 classical (c) SDRs; Region: SDR_c; cd05233 685727000563 NAD(P) binding site [chemical binding]; other site 685727000564 active site 685727000565 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 685727000566 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 685727000567 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 685727000568 classical (c) SDRs; Region: SDR_c; cd05233 685727000569 NAD(P) binding site [chemical binding]; other site 685727000570 active site 685727000571 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 685727000572 FAD binding domain; Region: FAD_binding_4; pfam01565 685727000573 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 685727000574 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 685727000575 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 685727000576 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 685727000577 Predicted membrane protein [Function unknown]; Region: COG2246 685727000578 GtrA-like protein; Region: GtrA; pfam04138 685727000579 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 685727000580 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 685727000581 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 685727000582 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 685727000583 protein binding site [polypeptide binding]; other site 685727000584 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 685727000585 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 685727000586 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 685727000587 substrate binding site; other site 685727000588 tetramer interface; other site 685727000589 proline/glycine betaine transporter; Provisional; Region: PRK10642 685727000590 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727000591 putative substrate translocation pore; other site 685727000592 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 685727000593 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 685727000594 NAD binding site [chemical binding]; other site 685727000595 substrate binding site [chemical binding]; other site 685727000596 homodimer interface [polypeptide binding]; other site 685727000597 active site 685727000598 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 685727000599 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 685727000600 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 685727000601 Ligand binding site; other site 685727000602 Putative Catalytic site; other site 685727000603 DXD motif; other site 685727000604 Predicted membrane protein [Function unknown]; Region: COG2246 685727000605 GtrA-like protein; Region: GtrA; pfam04138 685727000606 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 685727000607 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 685727000608 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 685727000609 active site 685727000610 Methyltransferase domain; Region: Methyltransf_24; pfam13578 685727000611 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 685727000612 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 685727000613 active site 685727000614 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 685727000615 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 685727000616 Walker A/P-loop; other site 685727000617 ATP binding site [chemical binding]; other site 685727000618 Q-loop/lid; other site 685727000619 ABC transporter signature motif; other site 685727000620 Walker B; other site 685727000621 D-loop; other site 685727000622 H-loop/switch region; other site 685727000623 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 685727000624 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 685727000625 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 685727000626 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 685727000627 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 685727000628 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 685727000629 catalytic residue [active] 685727000630 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 685727000631 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 685727000632 NAD(P) binding site [chemical binding]; other site 685727000633 Transcriptional regulators [Transcription]; Region: MarR; COG1846 685727000634 MarR family; Region: MarR; pfam01047 685727000635 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 685727000636 Putative esterase; Region: Esterase; pfam00756 685727000637 S-formylglutathione hydrolase; Region: PLN02442 685727000638 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 685727000639 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 685727000640 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 685727000641 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 685727000642 putative active site [active] 685727000643 putative metal binding site [ion binding]; other site 685727000644 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 685727000645 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 685727000646 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 685727000647 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685727000648 homodimer interface [polypeptide binding]; other site 685727000649 catalytic residue [active] 685727000650 Dienelactone hydrolase family; Region: DLH; pfam01738 685727000651 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 685727000652 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 685727000653 putative acyl-acceptor binding pocket; other site 685727000654 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 685727000655 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 685727000656 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 685727000657 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 685727000658 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 685727000659 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 685727000660 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 685727000661 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 685727000662 Domain of unknown function DUF21; Region: DUF21; pfam01595 685727000663 FOG: CBS domain [General function prediction only]; Region: COG0517 685727000664 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 685727000665 Domain of unknown function DUF21; Region: DUF21; pfam01595 685727000666 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 685727000667 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 685727000668 Transporter associated domain; Region: CorC_HlyC; pfam03471 685727000669 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159 685727000670 putative ligand binding site [chemical binding]; other site 685727000671 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 685727000672 putative NAD binding site [chemical binding]; other site 685727000673 catalytic site [active] 685727000674 classical (c) SDRs; Region: SDR_c; cd05233 685727000675 NAD(P) binding site [chemical binding]; other site 685727000676 active site 685727000677 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 685727000678 CoenzymeA binding site [chemical binding]; other site 685727000679 subunit interaction site [polypeptide binding]; other site 685727000680 PHB binding site; other site 685727000681 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 685727000682 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685727000683 S-adenosylmethionine binding site [chemical binding]; other site 685727000684 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 685727000685 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 685727000686 active site 685727000687 catalytic site [active] 685727000688 CAAX protease self-immunity; Region: Abi; pfam02517 685727000689 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 685727000690 Histidine kinase; Region: HisKA_3; pfam07730 685727000691 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 685727000692 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685727000693 active site 685727000694 phosphorylation site [posttranslational modification] 685727000695 intermolecular recognition site; other site 685727000696 dimerization interface [polypeptide binding]; other site 685727000697 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 685727000698 DNA binding residues [nucleotide binding] 685727000699 dimerization interface [polypeptide binding]; other site 685727000700 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 685727000701 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727000702 NAD(P) binding site [chemical binding]; other site 685727000703 active site 685727000704 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 685727000705 additional DNA contacts [nucleotide binding]; other site 685727000706 mismatch recognition site; other site 685727000707 active site 685727000708 zinc binding site [ion binding]; other site 685727000709 DNA intercalation site [nucleotide binding]; other site 685727000710 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 685727000711 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 685727000712 cofactor binding site; other site 685727000713 DNA binding site [nucleotide binding] 685727000714 substrate interaction site [chemical binding]; other site 685727000715 MarR family; Region: MarR_2; pfam12802 685727000716 Transcriptional regulators [Transcription]; Region: MarR; COG1846 685727000717 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 685727000718 Coenzyme A binding pocket [chemical binding]; other site 685727000719 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 685727000720 Clp amino terminal domain; Region: Clp_N; pfam02861 685727000721 Clp amino terminal domain; Region: Clp_N; pfam02861 685727000722 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685727000723 Walker A motif; other site 685727000724 ATP binding site [chemical binding]; other site 685727000725 Walker B motif; other site 685727000726 arginine finger; other site 685727000727 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685727000728 Walker A motif; other site 685727000729 ATP binding site [chemical binding]; other site 685727000730 Walker B motif; other site 685727000731 arginine finger; other site 685727000732 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 685727000733 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 685727000734 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 685727000735 Amidase; Region: Amidase; cl11426 685727000736 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 685727000737 prephenate dehydrogenase; Validated; Region: PRK08507 685727000738 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 685727000739 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 685727000740 nucleoside/Zn binding site; other site 685727000741 dimer interface [polypeptide binding]; other site 685727000742 catalytic motif [active] 685727000743 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 685727000744 classical (c) SDRs; Region: SDR_c; cd05233 685727000745 NAD(P) binding site [chemical binding]; other site 685727000746 active site 685727000747 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 685727000748 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 685727000749 Domain of unknown function (DUF336); Region: DUF336; cl01249 685727000750 Protein of unknown function (DUF664); Region: DUF664; pfam04978 685727000751 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 685727000752 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 685727000753 non-specific DNA binding site [nucleotide binding]; other site 685727000754 salt bridge; other site 685727000755 sequence-specific DNA binding site [nucleotide binding]; other site 685727000756 Cupin domain; Region: Cupin_2; pfam07883 685727000757 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 685727000758 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685727000759 motif II; other site 685727000760 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 685727000761 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 685727000762 active site 685727000763 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 685727000764 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 685727000765 Predicted GTPase [General function prediction only]; Region: ThdF; COG0486 685727000766 Lsr2; Region: Lsr2; pfam11774 685727000767 putative PEP-CTERM system histidine kinase; Region: PEP_his_kin; TIGR02916 685727000768 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 685727000769 MarR family; Region: MarR; pfam01047 685727000770 H+ Antiporter protein; Region: 2A0121; TIGR00900 685727000771 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727000772 putative substrate translocation pore; other site 685727000773 Major Facilitator Superfamily; Region: MFS_1; pfam07690 685727000774 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 685727000775 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 685727000776 DNA binding residues [nucleotide binding] 685727000777 drug binding residues [chemical binding]; other site 685727000778 dimer interface [polypeptide binding]; other site 685727000779 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 685727000780 beta-clamp/clamp loader binding surface; other site 685727000781 beta-clamp/translesion DNA polymerase binding surface; other site 685727000782 YceI-like domain; Region: YceI; pfam04264 685727000783 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 685727000784 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 685727000785 Predicted transcriptional regulator [Transcription]; Region: COG1959 685727000786 Transcriptional regulator; Region: Rrf2; pfam02082 685727000787 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685727000788 S-adenosylmethionine binding site [chemical binding]; other site 685727000789 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 685727000790 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727000791 MMPL family; Region: MMPL; pfam03176 685727000792 Thermoplasma acidophilum protein TA0956; Region: TA0956; pfam11513 685727000793 MMPL family; Region: MMPL; pfam03176 685727000794 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 685727000795 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 685727000796 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685727000797 Walker A/P-loop; other site 685727000798 ATP binding site [chemical binding]; other site 685727000799 Q-loop/lid; other site 685727000800 ABC transporter signature motif; other site 685727000801 Walker B; other site 685727000802 D-loop; other site 685727000803 H-loop/switch region; other site 685727000804 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 685727000805 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 685727000806 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 685727000807 Walker A/P-loop; other site 685727000808 ATP binding site [chemical binding]; other site 685727000809 Q-loop/lid; other site 685727000810 ABC transporter signature motif; other site 685727000811 Walker B; other site 685727000812 D-loop; other site 685727000813 H-loop/switch region; other site 685727000814 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 685727000815 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 685727000816 active site 685727000817 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 685727000818 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 685727000819 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 685727000820 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 685727000821 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 685727000822 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 685727000823 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 685727000824 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 685727000825 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685727000826 S-adenosylmethionine binding site [chemical binding]; other site 685727000827 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 685727000828 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 685727000829 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 685727000830 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 685727000831 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 685727000832 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 685727000833 active site 685727000834 HIGH motif; other site 685727000835 nucleotide binding site [chemical binding]; other site 685727000836 active site 685727000837 KMSKS motif; other site 685727000838 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 685727000839 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 685727000840 D-pathway; other site 685727000841 Putative ubiquinol binding site [chemical binding]; other site 685727000842 Low-spin heme (heme b) binding site [chemical binding]; other site 685727000843 Putative water exit pathway; other site 685727000844 Binuclear center (heme o3/CuB) [ion binding]; other site 685727000845 K-pathway; other site 685727000846 Putative proton exit pathway; other site 685727000847 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 685727000848 TIGR03086 family protein; Region: TIGR03086 685727000849 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 685727000850 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685727000851 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 685727000852 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 685727000853 oxidoreductase; Provisional; Region: PRK06128 685727000854 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 685727000855 NAD binding site [chemical binding]; other site 685727000856 metal binding site [ion binding]; metal-binding site 685727000857 active site 685727000858 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 685727000859 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 685727000860 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 685727000861 catalytic residue [active] 685727000862 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 685727000863 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 685727000864 intersubunit interface [polypeptide binding]; other site 685727000865 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 685727000866 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 685727000867 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 685727000868 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685727000869 S-adenosylmethionine binding site [chemical binding]; other site 685727000870 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 685727000871 putative dimer interface [polypeptide binding]; other site 685727000872 cell division protein FtsW; Region: ftsW; TIGR02614 685727000873 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 685727000874 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 685727000875 active site 685727000876 metal binding site [ion binding]; metal-binding site 685727000877 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 685727000878 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 685727000879 siderophore binding site; other site 685727000880 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 685727000881 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 685727000882 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 685727000883 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 685727000884 hydrophobic ligand binding site; other site 685727000885 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 685727000886 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 685727000887 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 685727000888 substrate binding site [chemical binding]; other site 685727000889 ATP binding site [chemical binding]; other site 685727000890 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 685727000891 intersubunit interface [polypeptide binding]; other site 685727000892 active site 685727000893 Zn2+ binding site [ion binding]; other site 685727000894 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 685727000895 DNA-binding site [nucleotide binding]; DNA binding site 685727000896 RNA-binding motif; other site 685727000897 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 685727000898 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 685727000899 putative di-iron ligands [ion binding]; other site 685727000900 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 685727000901 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 685727000902 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685727000903 Walker A motif; other site 685727000904 ATP binding site [chemical binding]; other site 685727000905 Walker B motif; other site 685727000906 arginine finger; other site 685727000907 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 685727000908 Transcriptional regulator [Transcription]; Region: IclR; COG1414 685727000909 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 685727000910 Bacterial transcriptional regulator; Region: IclR; pfam01614 685727000911 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 685727000912 Coenzyme A binding pocket [chemical binding]; other site 685727000913 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 685727000914 active site 685727000915 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685727000916 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 685727000917 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685727000918 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 685727000919 Histidine kinase; Region: HisKA_3; pfam07730 685727000920 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685727000921 ATP binding site [chemical binding]; other site 685727000922 Mg2+ binding site [ion binding]; other site 685727000923 G-X-G motif; other site 685727000924 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 685727000925 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685727000926 active site 685727000927 phosphorylation site [posttranslational modification] 685727000928 intermolecular recognition site; other site 685727000929 dimerization interface [polypeptide binding]; other site 685727000930 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 685727000931 DNA binding residues [nucleotide binding] 685727000932 dimerization interface [polypeptide binding]; other site 685727000933 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 685727000934 Amidase; Region: Amidase; cl11426 685727000935 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 685727000936 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 685727000937 dimer interface [polypeptide binding]; other site 685727000938 active site 685727000939 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 685727000940 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 685727000941 substrate binding site [chemical binding]; other site 685727000942 oxyanion hole (OAH) forming residues; other site 685727000943 trimer interface [polypeptide binding]; other site 685727000944 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 685727000945 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 685727000946 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 685727000947 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 685727000948 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727000949 Transcriptional regulator [Transcription]; Region: IclR; COG1414 685727000950 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 685727000951 Bacterial transcriptional regulator; Region: IclR; pfam01614 685727000952 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 685727000953 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685727000954 S-adenosylmethionine binding site [chemical binding]; other site 685727000955 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 685727000956 FAD binding domain; Region: FAD_binding_4; pfam01565 685727000957 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 685727000958 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 685727000959 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 685727000960 hydrophobic ligand binding site; other site 685727000961 hypothetical protein; Validated; Region: PRK00153 685727000962 recombination protein RecR; Reviewed; Region: recR; PRK00076 685727000963 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 685727000964 RecR protein; Region: RecR; pfam02132 685727000965 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 685727000966 putative active site [active] 685727000967 putative metal-binding site [ion binding]; other site 685727000968 tetramer interface [polypeptide binding]; other site 685727000969 Transcriptional regulator [Transcription]; Region: LysR; COG0583 685727000970 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685727000971 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 685727000972 dimerization interface [polypeptide binding]; other site 685727000973 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 685727000974 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 685727000975 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 685727000976 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 685727000977 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 685727000978 acyl-activating enzyme (AAE) consensus motif; other site 685727000979 putative AMP binding site [chemical binding]; other site 685727000980 putative active site [active] 685727000981 acyl-activating enzyme (AAE) consensus motif; other site 685727000982 putative CoA binding site [chemical binding]; other site 685727000983 Transcriptional regulator [Transcription]; Region: LysR; COG0583 685727000984 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685727000985 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 685727000986 putative dimerization interface [polypeptide binding]; other site 685727000987 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 685727000988 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 685727000989 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 685727000990 NAD(P) binding site [chemical binding]; other site 685727000991 catalytic residues [active] 685727000992 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 685727000993 cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207 685727000994 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 685727000995 active site 685727000996 Transcriptional regulators [Transcription]; Region: GntR; COG1802 685727000997 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 685727000998 DNA-binding site [nucleotide binding]; DNA binding site 685727000999 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 685727001000 GXWXG protein; Region: GXWXG; pfam14231 685727001001 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 685727001002 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 685727001003 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 685727001004 catalytic Zn binding site [ion binding]; other site 685727001005 NAD binding site [chemical binding]; other site 685727001006 structural Zn binding site [ion binding]; other site 685727001007 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727001008 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727001009 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727001010 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727001011 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 685727001012 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 685727001013 FMN binding site [chemical binding]; other site 685727001014 substrate binding site [chemical binding]; other site 685727001015 putative catalytic residue [active] 685727001016 enoyl-CoA hydratase; Provisional; Region: PRK06688 685727001017 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 685727001018 substrate binding site [chemical binding]; other site 685727001019 oxyanion hole (OAH) forming residues; other site 685727001020 trimer interface [polypeptide binding]; other site 685727001021 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 685727001022 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 685727001023 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 685727001024 acyl-activating enzyme (AAE) consensus motif; other site 685727001025 acyl-activating enzyme (AAE) consensus motif; other site 685727001026 putative AMP binding site [chemical binding]; other site 685727001027 putative active site [active] 685727001028 putative CoA binding site [chemical binding]; other site 685727001029 Permease; Region: Permease; pfam02405 685727001030 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 685727001031 Permease; Region: Permease; pfam02405 685727001032 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 685727001033 mce related protein; Region: MCE; pfam02470 685727001034 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 685727001035 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 685727001036 mce related protein; Region: MCE; pfam02470 685727001037 mce related protein; Region: MCE; pfam02470 685727001038 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 685727001039 mce related protein; Region: MCE; pfam02470 685727001040 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 685727001041 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 685727001042 mce related protein; Region: MCE; pfam02470 685727001043 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 685727001044 mce related protein; Region: MCE; pfam02470 685727001045 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 685727001046 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 685727001047 catalytic triad [active] 685727001048 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 685727001049 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 685727001050 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 685727001051 Short C-terminal domain; Region: SHOCT; pfam09851 685727001052 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 685727001053 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 685727001054 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 685727001055 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 685727001056 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 685727001057 [4Fe-4S] binding site [ion binding]; other site 685727001058 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 685727001059 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 685727001060 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 685727001061 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 685727001062 molybdopterin cofactor binding site; other site 685727001063 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 685727001064 gating phenylalanine in ion channel; other site 685727001065 short chain dehydrogenase; Provisional; Region: PRK07478 685727001066 classical (c) SDRs; Region: SDR_c; cd05233 685727001067 NAD(P) binding site [chemical binding]; other site 685727001068 active site 685727001069 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 685727001070 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 685727001071 active site 685727001072 FMN binding site [chemical binding]; other site 685727001073 substrate binding site [chemical binding]; other site 685727001074 putative catalytic residue [active] 685727001075 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 685727001076 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 685727001077 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 685727001078 TspO/MBR family; Region: TspO_MBR; pfam03073 685727001079 2-isopropylmalate synthase; Validated; Region: PRK03739 685727001080 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 685727001081 active site 685727001082 catalytic residues [active] 685727001083 metal binding site [ion binding]; metal-binding site 685727001084 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 685727001085 AAA ATPase domain; Region: AAA_16; pfam13191 685727001086 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 685727001087 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 685727001088 DNA binding residues [nucleotide binding] 685727001089 dimerization interface [polypeptide binding]; other site 685727001090 additional locus_tag=REQ_04350; additional locus_tag=REQ_04360 685727001091 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 685727001092 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 685727001093 Sulfate transporter family; Region: Sulfate_transp; pfam00916 685727001094 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 685727001095 additional locus_tag=REQ_04380 685727001096 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 685727001097 aspartate kinase; Reviewed; Region: PRK06635 685727001098 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 685727001099 putative nucleotide binding site [chemical binding]; other site 685727001100 putative catalytic residues [active] 685727001101 putative Mg ion binding site [ion binding]; other site 685727001102 putative aspartate binding site [chemical binding]; other site 685727001103 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 685727001104 putative allosteric regulatory site; other site 685727001105 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 685727001106 putative allosteric regulatory residue; other site 685727001107 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 685727001108 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 685727001109 BCCT family transporter; Region: BCCT; pfam02028 685727001110 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 685727001111 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 685727001112 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 685727001113 homotrimer interaction site [polypeptide binding]; other site 685727001114 putative active site [active] 685727001115 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 685727001116 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 685727001117 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 685727001118 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 685727001119 DNA binding residues [nucleotide binding] 685727001120 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 685727001121 Cl- selectivity filter; other site 685727001122 Cl- binding residues [ion binding]; other site 685727001123 pore gating glutamate residue; other site 685727001124 dimer interface [polypeptide binding]; other site 685727001125 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 685727001126 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 685727001127 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 685727001128 Multicopper oxidase; Region: Cu-oxidase; pfam00394 685727001129 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 685727001130 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 685727001131 dimerization interface [polypeptide binding]; other site 685727001132 putative DNA binding site [nucleotide binding]; other site 685727001133 putative Zn2+ binding site [ion binding]; other site 685727001134 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 685727001135 arsenical-resistance protein; Region: acr3; TIGR00832 685727001136 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 685727001137 Low molecular weight phosphatase family; Region: LMWPc; cd00115 685727001138 active site 685727001139 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 685727001140 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 685727001141 putative metal binding site [ion binding]; other site 685727001142 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 685727001143 dimerization interface [polypeptide binding]; other site 685727001144 putative DNA binding site [nucleotide binding]; other site 685727001145 putative Zn2+ binding site [ion binding]; other site 685727001146 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 685727001147 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 685727001148 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 685727001149 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 685727001150 dimer interface [polypeptide binding]; other site 685727001151 active site 685727001152 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 685727001153 Ligand Binding Site [chemical binding]; other site 685727001154 Molecular Tunnel; other site 685727001155 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 685727001156 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 685727001157 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 685727001158 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 685727001159 metal binding site [ion binding]; metal-binding site 685727001160 putative dimer interface [polypeptide binding]; other site 685727001161 Methyltransferase domain; Region: Methyltransf_31; pfam13847 685727001162 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685727001163 S-adenosylmethionine binding site [chemical binding]; other site 685727001164 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 685727001165 Transcriptional regulator [Transcription]; Region: IclR; COG1414 685727001166 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 685727001167 Bacterial transcriptional regulator; Region: IclR; pfam01614 685727001168 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 685727001169 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727001170 NAD(P) binding site [chemical binding]; other site 685727001171 active site 685727001172 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727001173 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 685727001174 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 685727001175 putative hydrophobic ligand binding site [chemical binding]; other site 685727001176 protein interface [polypeptide binding]; other site 685727001177 gate; other site 685727001178 ferric uptake regulator; Provisional; Region: fur; PRK09462 685727001179 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 685727001180 metal binding site 2 [ion binding]; metal-binding site 685727001181 putative DNA binding helix; other site 685727001182 metal binding site 1 [ion binding]; metal-binding site 685727001183 dimer interface [polypeptide binding]; other site 685727001184 structural Zn2+ binding site [ion binding]; other site 685727001185 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 685727001186 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 685727001187 tetramer interface [polypeptide binding]; other site 685727001188 heme binding pocket [chemical binding]; other site 685727001189 NADPH binding site [chemical binding]; other site 685727001190 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 685727001191 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 685727001192 catalytic residue [active] 685727001193 MFS/sugar transport protein; Region: MFS_2; pfam13347 685727001194 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 685727001195 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 685727001196 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 685727001197 FAD binding domain; Region: FAD_binding_4; pfam01565 685727001198 Cholesterol oxidase, substrate-binding; Region: Chol_subst-bind; pfam09129 685727001199 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 685727001200 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 685727001201 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 685727001202 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 685727001203 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 685727001204 siderophore binding site; other site 685727001205 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 685727001206 homotrimer interaction site [polypeptide binding]; other site 685727001207 putative active site [active] 685727001208 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 685727001209 FAD binding domain; Region: FAD_binding_4; pfam01565 685727001210 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 685727001211 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 685727001212 active site 685727001213 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 685727001214 Transcriptional regulator [Transcription]; Region: LysR; COG0583 685727001215 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685727001216 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 685727001217 dimerization interface [polypeptide binding]; other site 685727001218 substrate binding pocket [chemical binding]; other site 685727001219 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 685727001220 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 685727001221 putative active site [active] 685727001222 putative metal binding site [ion binding]; other site 685727001223 Yqey-like protein; Region: YqeY; pfam09424 685727001224 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 685727001225 intracellular protease, PfpI family; Region: PfpI; TIGR01382 685727001226 proposed catalytic triad [active] 685727001227 conserved cys residue [active] 685727001228 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727001229 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 685727001230 classical (c) SDRs; Region: SDR_c; cd05233 685727001231 NAD(P) binding site [chemical binding]; other site 685727001232 active site 685727001233 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 685727001234 Uncharacterized conserved protein [Function unknown]; Region: COG4279 685727001235 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 685727001236 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 685727001237 ATP binding site [chemical binding]; other site 685727001238 putative Mg++ binding site [ion binding]; other site 685727001239 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 685727001240 nucleotide binding region [chemical binding]; other site 685727001241 ATP-binding site [chemical binding]; other site 685727001242 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727001243 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727001244 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 685727001245 2-hydroxymuconic semialdehyde dehydrogenase; Region: OH_muco_semi_DH; TIGR03216 685727001246 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 685727001247 NAD binding site [chemical binding]; other site 685727001248 catalytic residues [active] 685727001249 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 685727001250 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 685727001251 homotrimer interaction site [polypeptide binding]; other site 685727001252 putative active site [active] 685727001253 3-hydroxyanthranilate 3,4-dioxygenase; Provisional; Region: PRK13264 685727001254 Amidohydrolase; Region: Amidohydro_2; pfam04909 685727001255 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727001256 metabolite-proton symporter; Region: 2A0106; TIGR00883 685727001257 putative substrate translocation pore; other site 685727001258 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 685727001259 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685727001260 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 685727001261 dimerization interface [polypeptide binding]; other site 685727001262 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 685727001263 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 685727001264 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 685727001265 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 685727001266 ligand binding site [chemical binding]; other site 685727001267 flexible hinge region; other site 685727001268 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 685727001269 putative switch regulator; other site 685727001270 non-specific DNA interactions [nucleotide binding]; other site 685727001271 DNA binding site [nucleotide binding] 685727001272 sequence specific DNA binding site [nucleotide binding]; other site 685727001273 putative cAMP binding site [chemical binding]; other site 685727001274 amino acid transporter; Region: 2A0306; TIGR00909 685727001275 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 685727001276 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 685727001277 minor groove reading motif; other site 685727001278 helix-hairpin-helix signature motif; other site 685727001279 substrate binding pocket [chemical binding]; other site 685727001280 active site 685727001281 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 685727001282 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 685727001283 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 685727001284 catalytic residues [active] 685727001285 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 685727001286 putative active site [active] 685727001287 putative CoA binding site [chemical binding]; other site 685727001288 nudix motif; other site 685727001289 metal binding site [ion binding]; metal-binding site 685727001290 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 685727001291 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 685727001292 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 685727001293 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 685727001294 Serine hydrolase (FSH1); Region: FSH1; pfam03959 685727001295 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 685727001296 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 685727001297 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727001298 metabolite-proton symporter; Region: 2A0106; TIGR00883 685727001299 putative substrate translocation pore; other site 685727001300 DUF35 OB-fold domain; Region: DUF35; pfam01796 685727001301 AAA ATPase domain; Region: AAA_16; pfam13191 685727001302 Predicted ATPase [General function prediction only]; Region: COG3903 685727001303 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 685727001304 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 685727001305 DNA binding residues [nucleotide binding] 685727001306 dimerization interface [polypeptide binding]; other site 685727001307 acetyl-CoA synthetase; Provisional; Region: PRK00174 685727001308 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 685727001309 active site 685727001310 CoA binding site [chemical binding]; other site 685727001311 acyl-activating enzyme (AAE) consensus motif; other site 685727001312 AMP binding site [chemical binding]; other site 685727001313 acetate binding site [chemical binding]; other site 685727001314 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 685727001315 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 685727001316 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 685727001317 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685727001318 dimer interface [polypeptide binding]; other site 685727001319 conserved gate region; other site 685727001320 ABC-ATPase subunit interface; other site 685727001321 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 685727001322 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685727001323 dimer interface [polypeptide binding]; other site 685727001324 conserved gate region; other site 685727001325 putative PBP binding loops; other site 685727001326 ABC-ATPase subunit interface; other site 685727001327 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 685727001328 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 685727001329 Walker A/P-loop; other site 685727001330 ATP binding site [chemical binding]; other site 685727001331 Q-loop/lid; other site 685727001332 ABC transporter signature motif; other site 685727001333 Walker B; other site 685727001334 D-loop; other site 685727001335 H-loop/switch region; other site 685727001336 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 685727001337 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 685727001338 Walker A/P-loop; other site 685727001339 ATP binding site [chemical binding]; other site 685727001340 Q-loop/lid; other site 685727001341 ABC transporter signature motif; other site 685727001342 Walker B; other site 685727001343 D-loop; other site 685727001344 H-loop/switch region; other site 685727001345 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 685727001346 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685727001347 motif II; other site 685727001348 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 685727001349 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 685727001350 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 685727001351 ATP binding site [chemical binding]; other site 685727001352 Walker A motif; other site 685727001353 hexamer interface [polypeptide binding]; other site 685727001354 Walker B motif; other site 685727001355 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 685727001356 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 685727001357 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 685727001358 ATP binding site [chemical binding]; other site 685727001359 putative Mg++ binding site [ion binding]; other site 685727001360 nucleotide binding region [chemical binding]; other site 685727001361 helicase superfamily c-terminal domain; Region: HELICc; smart00490 685727001362 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 685727001363 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 685727001364 DNA-binding site [nucleotide binding]; DNA binding site 685727001365 RNA-binding motif; other site 685727001366 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 685727001367 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 685727001368 active site 685727001369 interdomain interaction site; other site 685727001370 putative metal-binding site [ion binding]; other site 685727001371 nucleotide binding site [chemical binding]; other site 685727001372 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 685727001373 domain I; other site 685727001374 phosphate binding site [ion binding]; other site 685727001375 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 685727001376 domain II; other site 685727001377 domain III; other site 685727001378 nucleotide binding site [chemical binding]; other site 685727001379 DNA binding groove [nucleotide binding] 685727001380 catalytic site [active] 685727001381 domain IV; other site 685727001382 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 685727001383 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 685727001384 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 685727001385 DNA polymerase III subunit delta'; Validated; Region: PRK07940 685727001386 DNA polymerase III subunit delta'; Validated; Region: PRK08485 685727001387 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 685727001388 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 685727001389 DNA-binding site [nucleotide binding]; DNA binding site 685727001390 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 685727001391 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685727001392 Walker A/P-loop; other site 685727001393 ATP binding site [chemical binding]; other site 685727001394 Q-loop/lid; other site 685727001395 ABC transporter signature motif; other site 685727001396 Walker B; other site 685727001397 D-loop; other site 685727001398 Transcriptional regulators [Transcription]; Region: FadR; COG2186 685727001399 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 685727001400 DNA-binding site [nucleotide binding]; DNA binding site 685727001401 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 685727001402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727001403 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 685727001404 Zn binding site [ion binding]; other site 685727001405 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 685727001406 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 685727001407 acyl-activating enzyme (AAE) consensus motif; other site 685727001408 AMP binding site [chemical binding]; other site 685727001409 active site 685727001410 CoA binding site [chemical binding]; other site 685727001411 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 685727001412 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 685727001413 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 685727001414 putative trimer interface [polypeptide binding]; other site 685727001415 putative CoA binding site [chemical binding]; other site 685727001416 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 685727001417 putative trimer interface [polypeptide binding]; other site 685727001418 putative CoA binding site [chemical binding]; other site 685727001419 YCII-related domain; Region: YCII; cl00999 685727001420 YCII-related domain; Region: YCII; cl00999 685727001422 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 685727001423 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 685727001424 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 685727001425 catalytic residue [active] 685727001426 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 685727001427 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 685727001428 short chain dehydrogenase; Provisional; Region: PRK06523 685727001429 classical (c) SDRs; Region: SDR_c; cd05233 685727001430 NAD(P) binding site [chemical binding]; other site 685727001431 active site 685727001432 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 685727001433 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 685727001434 putative deacylase active site [active] 685727001435 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 685727001436 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727001437 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727001438 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 685727001439 putative OHCU decarboxylase; Provisional; Region: PRK13798 685727001440 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 685727001441 active site 685727001442 metal binding site [ion binding]; metal-binding site 685727001443 Uncharacterized conserved protein [Function unknown]; Region: COG2128 685727001444 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 685727001445 enoyl-CoA hydratase; Provisional; Region: PRK06142 685727001446 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 685727001447 substrate binding site [chemical binding]; other site 685727001448 oxyanion hole (OAH) forming residues; other site 685727001449 trimer interface [polypeptide binding]; other site 685727001450 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727001451 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 685727001452 putative substrate translocation pore; other site 685727001453 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 685727001454 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 685727001455 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 685727001456 DNA binding residues [nucleotide binding] 685727001457 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 685727001458 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 685727001459 Uncharacterized conserved protein [Function unknown]; Region: COG2128 685727001460 LexA repressor; Validated; Region: PRK00215 685727001461 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 685727001462 non-specific DNA interactions [nucleotide binding]; other site 685727001463 DNA binding site [nucleotide binding] 685727001464 sequence specific DNA binding site [nucleotide binding]; other site 685727001465 putative cAMP binding site [chemical binding]; other site 685727001466 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 685727001467 Catalytic site [active] 685727001468 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 685727001469 dimer interface [polypeptide binding]; other site 685727001470 substrate binding site [chemical binding]; other site 685727001471 metal binding sites [ion binding]; metal-binding site 685727001472 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 685727001473 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 685727001474 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 685727001475 putative hydrolase; Region: TIGR03624 685727001476 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 685727001477 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 685727001478 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 685727001479 active site 685727001480 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 685727001481 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 685727001482 active site 685727001483 ATP binding site [chemical binding]; other site 685727001484 substrate binding site [chemical binding]; other site 685727001485 activation loop (A-loop); other site 685727001486 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 685727001487 Amidase; Region: Amidase; cl11426 685727001488 FtsH Extracellular; Region: FtsH_ext; pfam06480 685727001489 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 685727001490 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685727001491 Walker A motif; other site 685727001492 ATP binding site [chemical binding]; other site 685727001493 Walker B motif; other site 685727001494 arginine finger; other site 685727001495 Peptidase family M41; Region: Peptidase_M41; pfam01434 685727001496 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 685727001497 GTP cyclohydrolase I; Provisional; Region: PLN03044 685727001498 homodecamer interface [polypeptide binding]; other site 685727001499 active site 685727001500 putative catalytic site residues [active] 685727001501 zinc binding site [ion binding]; other site 685727001502 GTP-CH-I/GFRP interaction surface; other site 685727001503 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 685727001504 dihydropteroate synthase; Region: DHPS; TIGR01496 685727001505 substrate binding pocket [chemical binding]; other site 685727001506 dimer interface [polypeptide binding]; other site 685727001507 inhibitor binding site; inhibition site 685727001508 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 685727001509 homooctamer interface [polypeptide binding]; other site 685727001510 active site 685727001511 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 685727001512 catalytic center binding site [active] 685727001513 ATP binding site [chemical binding]; other site 685727001514 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 685727001515 Uncharacterized conserved protein [Function unknown]; Region: COG5495 685727001516 Rossmann-like domain; Region: Rossmann-like; pfam10727 685727001517 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 685727001518 pantoate--beta-alanine ligase; Region: panC; TIGR00018 685727001519 Pantoate-beta-alanine ligase; Region: PanC; cd00560 685727001520 active site 685727001521 ATP-binding site [chemical binding]; other site 685727001522 pantoate-binding site; other site 685727001523 HXXH motif; other site 685727001524 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 685727001525 tetramerization interface [polypeptide binding]; other site 685727001526 active site 685727001527 pantothenate kinase; Reviewed; Region: PRK13318 685727001528 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 685727001529 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 685727001530 active site residue [active] 685727001531 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 685727001532 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 685727001533 dimer interface [polypeptide binding]; other site 685727001534 putative anticodon binding site; other site 685727001535 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 685727001536 motif 1; other site 685727001537 dimer interface [polypeptide binding]; other site 685727001538 active site 685727001539 motif 2; other site 685727001540 motif 3; other site 685727001541 Lsr2; Region: Lsr2; pfam11774 685727001542 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 685727001543 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 685727001544 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 685727001545 DNA binding residues [nucleotide binding] 685727001546 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 685727001547 Clp amino terminal domain; Region: Clp_N; pfam02861 685727001548 Clp amino terminal domain; Region: Clp_N; pfam02861 685727001549 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685727001550 Walker A motif; other site 685727001551 ATP binding site [chemical binding]; other site 685727001552 Walker B motif; other site 685727001553 arginine finger; other site 685727001554 UvrB/uvrC motif; Region: UVR; pfam02151 685727001555 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685727001556 Walker A motif; other site 685727001557 ATP binding site [chemical binding]; other site 685727001558 Walker B motif; other site 685727001559 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 685727001560 hypothetical protein; Provisional; Region: PRK06547 685727001561 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727001562 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 685727001563 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 685727001564 thiocyanate hydrolase, gamma subunit; Region: thiocyan_alph; TIGR03887 685727001565 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 685727001566 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 685727001567 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 685727001568 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 685727001569 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 685727001570 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 685727001571 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 685727001572 Histidine kinase; Region: HisKA_3; pfam07730 685727001573 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 685727001574 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685727001575 active site 685727001576 phosphorylation site [posttranslational modification] 685727001577 intermolecular recognition site; other site 685727001578 dimerization interface [polypeptide binding]; other site 685727001579 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 685727001580 DNA binding residues [nucleotide binding] 685727001581 dimerization interface [polypeptide binding]; other site 685727001582 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 685727001583 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 685727001584 acyl-activating enzyme (AAE) consensus motif; other site 685727001585 AMP binding site [chemical binding]; other site 685727001586 active site 685727001587 CoA binding site [chemical binding]; other site 685727001588 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 685727001589 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 685727001590 catalytic residues [active] 685727001591 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 685727001592 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 685727001593 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 685727001594 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 685727001595 catalytic site [active] 685727001596 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 685727001597 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 685727001598 minor groove reading motif; other site 685727001599 helix-hairpin-helix signature motif; other site 685727001600 substrate binding pocket [chemical binding]; other site 685727001601 active site 685727001602 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 685727001603 active site clefts [active] 685727001604 zinc binding site [ion binding]; other site 685727001605 dimer interface [polypeptide binding]; other site 685727001606 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 685727001607 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 685727001608 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 685727001609 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 685727001610 CoenzymeA binding site [chemical binding]; other site 685727001611 subunit interaction site [polypeptide binding]; other site 685727001612 PHB binding site; other site 685727001613 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 685727001614 Walker A motif; other site 685727001615 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 685727001616 ATP binding site [chemical binding]; other site 685727001617 Walker B motif; other site 685727001618 Protein of unknown function (DUF461); Region: DUF461; cl01071 685727001619 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 685727001620 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 685727001621 substrate binding site; other site 685727001622 dimer interface; other site 685727001623 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 685727001624 homotrimer interaction site [polypeptide binding]; other site 685727001625 zinc binding site [ion binding]; other site 685727001626 CDP-binding sites; other site 685727001627 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 685727001628 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 685727001629 active site 685727001630 HIGH motif; other site 685727001631 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 685727001632 KMSKS motif; other site 685727001633 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 685727001634 tRNA binding surface [nucleotide binding]; other site 685727001635 anticodon binding site; other site 685727001636 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 685727001637 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 685727001638 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 685727001639 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 685727001640 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 685727001641 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 685727001642 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 685727001643 putative active site [active] 685727001644 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 685727001645 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 685727001646 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 685727001647 non-specific DNA binding site [nucleotide binding]; other site 685727001648 salt bridge; other site 685727001649 sequence-specific DNA binding site [nucleotide binding]; other site 685727001650 Cupin domain; Region: Cupin_2; pfam07883 685727001651 class II aldolase/adducin domain protein; Provisional; Region: PRK07090 685727001652 intersubunit interface [polypeptide binding]; other site 685727001653 active site 685727001654 Zn2+ binding site [ion binding]; other site 685727001655 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 685727001656 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 685727001657 inhibitor site; inhibition site 685727001658 active site 685727001659 dimer interface [polypeptide binding]; other site 685727001660 catalytic residue [active] 685727001661 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 685727001662 Coenzyme A binding pocket [chemical binding]; other site 685727001663 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 685727001664 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 685727001665 dimer interface [polypeptide binding]; other site 685727001666 putative PBP binding regions; other site 685727001667 ABC-ATPase subunit interface; other site 685727001668 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 685727001669 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 685727001670 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 685727001671 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 685727001672 intersubunit interface [polypeptide binding]; other site 685727001673 Transcriptional regulators [Transcription]; Region: PurR; COG1609 685727001674 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 685727001675 DNA binding site [nucleotide binding] 685727001676 domain linker motif; other site 685727001677 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 685727001678 putative dimerization interface [polypeptide binding]; other site 685727001679 putative ligand binding site [chemical binding]; other site 685727001680 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 685727001681 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 685727001682 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 685727001683 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 685727001684 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727001685 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727001686 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 685727001687 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 685727001688 active site 685727001689 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 685727001690 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 685727001691 active site 685727001692 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 685727001693 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 685727001694 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 685727001695 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 685727001696 active site 685727001697 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 685727001698 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 685727001699 DUF35 OB-fold domain; Region: DUF35; pfam01796 685727001700 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 685727001701 putative active site [active] 685727001702 putative catalytic site [active] 685727001703 lipid-transfer protein; Provisional; Region: PRK07855 685727001704 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 685727001705 active site 685727001706 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 685727001707 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 685727001708 substrate binding pocket [chemical binding]; other site 685727001709 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 685727001710 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 685727001711 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 685727001712 active site 685727001713 non-prolyl cis peptide bond; other site 685727001714 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 685727001715 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 685727001716 active site 685727001717 catalytic tetrad [active] 685727001718 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 685727001719 classical (c) SDRs; Region: SDR_c; cd05233 685727001720 NAD(P) binding site [chemical binding]; other site 685727001721 active site 685727001722 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 685727001723 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 685727001724 inhibitor-cofactor binding pocket; inhibition site 685727001725 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685727001726 catalytic residue [active] 685727001727 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 685727001728 classical (c) SDRs; Region: SDR_c; cd05233 685727001729 NAD(P) binding site [chemical binding]; other site 685727001730 active site 685727001731 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 685727001732 active site 685727001733 metal binding site [ion binding]; metal-binding site 685727001734 Transcriptional regulator [Transcription]; Region: IclR; COG1414 685727001735 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 685727001736 Bacterial transcriptional regulator; Region: IclR; pfam01614 685727001737 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 685727001738 Sulfatase; Region: Sulfatase; pfam00884 685727001739 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727001740 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727001741 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 685727001742 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 685727001743 Domain of unknown function (DUF202); Region: DUF202; cl09954 685727001744 Domain of unknown function (DUF202); Region: DUF202; pfam02656 685727001745 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 685727001746 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727001747 NAD(P) binding site [chemical binding]; other site 685727001748 active site 685727001749 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727001750 putative substrate translocation pore; other site 685727001751 Interferon-induced transmembrane protein; Region: CD225; pfam04505 685727001752 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 685727001753 FAD binding domain; Region: FAD_binding_4; pfam01565 685727001754 Cholesterol oxidase, substrate-binding; Region: Chol_subst-bind; pfam09129 685727001755 enoyl-CoA hydratase; Region: PLN02864 685727001756 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 685727001757 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 685727001758 dimer interaction site [polypeptide binding]; other site 685727001759 substrate-binding tunnel; other site 685727001760 active site 685727001761 catalytic site [active] 685727001762 substrate binding site [chemical binding]; other site 685727001763 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 685727001764 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 685727001765 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 685727001766 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 685727001767 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 685727001768 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 685727001769 Flavin binding site [chemical binding]; other site 685727001770 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 685727001771 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 685727001772 catalytic site [active] 685727001773 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 685727001774 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 685727001775 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 685727001776 active site 685727001777 Fe binding site [ion binding]; other site 685727001778 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 685727001779 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 685727001780 hydrophobic ligand binding site; other site 685727001781 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734 685727001782 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 685727001783 short chain dehydrogenase; Provisional; Region: PRK05875 685727001784 classical (c) SDRs; Region: SDR_c; cd05233 685727001785 NAD(P) binding site [chemical binding]; other site 685727001786 active site 685727001787 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 685727001788 Cytochrome P450; Region: p450; cl12078 685727001789 Domain of unknown function (DUF222); Region: DUF222; pfam02720 685727001790 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 685727001791 active site 685727001792 Cupin domain; Region: Cupin_2; cl17218 685727001793 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 685727001794 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 685727001795 active site 685727001796 catalytic tetrad [active] 685727001797 SnoaL-like domain; Region: SnoaL_4; pfam13577 685727001798 classical (c) SDRs; Region: SDR_c; cd05233 685727001799 NAD(P) binding site [chemical binding]; other site 685727001800 active site 685727001801 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 685727001802 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685727001803 active site 685727001804 motif I; other site 685727001805 motif II; other site 685727001806 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 685727001807 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727001808 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727001809 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 685727001810 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 685727001811 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 685727001812 active site 685727001813 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 685727001814 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 685727001815 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 685727001816 active site 685727001817 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 685727001818 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 685727001819 FAD binding site [chemical binding]; other site 685727001820 substrate binding site [chemical binding]; other site 685727001821 catalytic base [active] 685727001822 enoyl-CoA hydratase; Provisional; Region: PRK08290 685727001823 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 685727001824 substrate binding site [chemical binding]; other site 685727001825 oxyanion hole (OAH) forming residues; other site 685727001826 trimer interface [polypeptide binding]; other site 685727001827 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 685727001828 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 685727001829 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 685727001830 acyl-activating enzyme (AAE) consensus motif; other site 685727001831 putative AMP binding site [chemical binding]; other site 685727001832 putative active site [active] 685727001833 putative CoA binding site [chemical binding]; other site 685727001834 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 685727001835 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 685727001836 active site 685727001837 short chain dehydrogenase; Provisional; Region: PRK07831 685727001838 classical (c) SDRs; Region: SDR_c; cd05233 685727001839 NAD(P) binding site [chemical binding]; other site 685727001840 active site 685727001841 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727001842 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727001843 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 685727001844 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 685727001845 dimer interface [polypeptide binding]; other site 685727001846 active site 685727001847 Methyltransferase domain; Region: Methyltransf_31; pfam13847 685727001848 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685727001849 S-adenosylmethionine binding site [chemical binding]; other site 685727001850 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 685727001851 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 685727001852 TAP-like protein; Region: Abhydrolase_4; pfam08386 685727001853 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 685727001854 DNA binding residues [nucleotide binding] 685727001855 dimerization interface [polypeptide binding]; other site 685727001856 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 685727001857 Sodium Bile acid symporter family; Region: SBF; cl17470 685727001858 Cytochrome P450; Region: p450; pfam00067 685727001859 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 685727001860 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 685727001861 Nitronate monooxygenase; Region: NMO; pfam03060 685727001862 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 685727001863 FMN binding site [chemical binding]; other site 685727001864 substrate binding site [chemical binding]; other site 685727001865 putative catalytic residue [active] 685727001866 Coenzyme A transferase; Region: CoA_trans; cl17247 685727001867 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 685727001868 enoyl-CoA hydratase; Provisional; Region: PRK06495 685727001869 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 685727001870 substrate binding site [chemical binding]; other site 685727001871 oxyanion hole (OAH) forming residues; other site 685727001872 trimer interface [polypeptide binding]; other site 685727001873 short chain dehydrogenase; Provisional; Region: PRK07856 685727001874 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727001875 NAD(P) binding site [chemical binding]; other site 685727001876 active site 685727001877 short chain dehydrogenase; Provisional; Region: PRK07791 685727001878 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727001879 NAD(P) binding site [chemical binding]; other site 685727001880 active site 685727001881 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 685727001882 primary dimer interface [polypeptide binding]; other site 685727001883 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 685727001884 Domain of unknown function (DUF385); Region: DUF385; pfam04075 685727001885 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 685727001886 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 685727001887 dimer interface [polypeptide binding]; other site 685727001888 active site 685727001889 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 685727001890 Cytochrome P450; Region: p450; cl12078 685727001891 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 685727001892 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 685727001893 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 685727001894 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 685727001895 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 685727001896 active site 685727001897 lipid-transfer protein; Provisional; Region: PRK07937 685727001898 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 685727001899 active site 685727001900 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 685727001901 DUF35 OB-fold domain; Region: DUF35; pfam01796 685727001902 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 685727001903 DUF35 OB-fold domain; Region: DUF35; pfam01796 685727001904 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 685727001905 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 685727001906 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 685727001907 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 685727001908 NAD binding site [chemical binding]; other site 685727001909 homodimer interface [polypeptide binding]; other site 685727001910 homotetramer interface [polypeptide binding]; other site 685727001911 active site 685727001912 acetyl-CoA acetyltransferase; Provisional; Region: PRK06504 685727001913 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 685727001914 dimer interface [polypeptide binding]; other site 685727001915 active site 685727001916 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727001917 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727001918 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 685727001919 enoyl-CoA hydratase; Provisional; Region: PRK07799 685727001920 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 685727001921 substrate binding site [chemical binding]; other site 685727001922 oxyanion hole (OAH) forming residues; other site 685727001923 trimer interface [polypeptide binding]; other site 685727001924 acyl-CoA synthetase; Validated; Region: PRK07798 685727001925 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 685727001926 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 685727001927 acyl-activating enzyme (AAE) consensus motif; other site 685727001928 acyl-activating enzyme (AAE) consensus motif; other site 685727001929 putative AMP binding site [chemical binding]; other site 685727001930 putative active site [active] 685727001931 putative CoA binding site [chemical binding]; other site 685727001932 Nitronate monooxygenase; Region: NMO; pfam03060 685727001933 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 685727001934 FMN binding site [chemical binding]; other site 685727001935 substrate binding site [chemical binding]; other site 685727001936 putative catalytic residue [active] 685727001937 acyl-CoA synthetase; Validated; Region: PRK07867 685727001938 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 685727001939 acyl-activating enzyme (AAE) consensus motif; other site 685727001940 AMP binding site [chemical binding]; other site 685727001941 active site 685727001942 CoA binding site [chemical binding]; other site 685727001943 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 685727001944 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 685727001945 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 685727001946 active site 685727001947 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 685727001948 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 685727001949 FAD binding site [chemical binding]; other site 685727001950 substrate binding site [chemical binding]; other site 685727001951 catalytic base [active] 685727001952 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 685727001953 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 685727001954 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727001955 NAD(P) binding site [chemical binding]; other site 685727001956 active site 685727001957 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 685727001958 Permease; Region: Permease; pfam02405 685727001959 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 685727001960 Permease; Region: Permease; pfam02405 685727001961 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 685727001962 mce related protein; Region: MCE; pfam02470 685727001963 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 685727001964 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 685727001965 mce related protein; Region: MCE; pfam02470 685727001966 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 685727001967 mce related protein; Region: MCE; pfam02470 685727001968 mce related protein; Region: MCE; pfam02470 685727001969 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 685727001970 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 685727001971 mce related protein; Region: MCE; pfam02470 685727001972 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 685727001973 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 685727001974 mce related protein; Region: MCE; pfam02470 685727001975 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 685727001976 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 685727001977 active site 685727001978 homotetramer interface [polypeptide binding]; other site 685727001979 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 685727001980 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 685727001981 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685727001982 Walker A/P-loop; other site 685727001983 ATP binding site [chemical binding]; other site 685727001984 Q-loop/lid; other site 685727001985 ABC transporter signature motif; other site 685727001986 Walker B; other site 685727001987 D-loop; other site 685727001988 H-loop/switch region; other site 685727001989 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 685727001990 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 685727001991 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685727001992 Walker A/P-loop; other site 685727001993 ATP binding site [chemical binding]; other site 685727001994 Q-loop/lid; other site 685727001995 ABC transporter signature motif; other site 685727001996 Walker B; other site 685727001997 D-loop; other site 685727001998 H-loop/switch region; other site 685727001999 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 685727002000 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 685727002001 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 685727002002 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 685727002003 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 685727002004 active site 685727002005 metal binding site [ion binding]; metal-binding site 685727002006 Protein of unknown function (DUF664); Region: DUF664; pfam04978 685727002007 DinB superfamily; Region: DinB_2; pfam12867 685727002008 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 685727002009 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 685727002010 active site 685727002011 substrate binding site [chemical binding]; other site 685727002012 cosubstrate binding site; other site 685727002013 catalytic site [active] 685727002014 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 685727002015 active site 685727002016 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 685727002017 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 685727002018 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 685727002019 Condensation domain; Region: Condensation; pfam00668 685727002020 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 685727002021 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 685727002022 acyl-activating enzyme (AAE) consensus motif; other site 685727002023 AMP binding site [chemical binding]; other site 685727002024 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 685727002025 Condensation domain; Region: Condensation; pfam00668 685727002026 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 685727002027 Condensation domain; Region: Condensation; pfam00668 685727002028 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 685727002029 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 685727002030 acyl-activating enzyme (AAE) consensus motif; other site 685727002031 AMP binding site [chemical binding]; other site 685727002032 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 685727002033 Condensation domain; Region: Condensation; pfam00668 685727002034 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 685727002035 Condensation domain; Region: Condensation; pfam00668 685727002036 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 685727002037 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 685727002038 acyl-activating enzyme (AAE) consensus motif; other site 685727002039 AMP binding site [chemical binding]; other site 685727002040 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 685727002041 Condensation domain; Region: Condensation; pfam00668 685727002042 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 685727002043 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 685727002044 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 685727002045 acyl-activating enzyme (AAE) consensus motif; other site 685727002046 AMP binding site [chemical binding]; other site 685727002047 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 685727002048 Condensation domain; Region: Condensation; pfam00668 685727002049 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 685727002050 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 685727002051 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 685727002052 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cl04270 685727002053 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 685727002054 Uncharacterized conserved protein [Function unknown]; Region: COG2966 685727002055 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 685727002056 Uncharacterized conserved protein [Function unknown]; Region: COG3610 685727002057 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 685727002058 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 685727002059 Methyltransferase domain; Region: Methyltransf_23; pfam13489 685727002060 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685727002061 S-adenosylmethionine binding site [chemical binding]; other site 685727002062 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 685727002063 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 685727002064 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 685727002065 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 685727002066 non-specific DNA binding site [nucleotide binding]; other site 685727002067 salt bridge; other site 685727002068 sequence-specific DNA binding site [nucleotide binding]; other site 685727002069 Cupin domain; Region: Cupin_2; pfam07883 685727002070 Dienelactone hydrolase family; Region: DLH; pfam01738 685727002071 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 685727002072 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 685727002073 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685727002074 active site 685727002075 phosphorylation site [posttranslational modification] 685727002076 intermolecular recognition site; other site 685727002077 dimerization interface [polypeptide binding]; other site 685727002078 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 685727002079 DNA binding site [nucleotide binding] 685727002080 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 685727002081 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 685727002082 dimerization interface [polypeptide binding]; other site 685727002083 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 685727002084 dimer interface [polypeptide binding]; other site 685727002085 phosphorylation site [posttranslational modification] 685727002086 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685727002087 ATP binding site [chemical binding]; other site 685727002088 Mg2+ binding site [ion binding]; other site 685727002089 G-X-G motif; other site 685727002090 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 685727002091 nucleotide binding site/active site [active] 685727002092 HIT family signature motif; other site 685727002093 catalytic residue [active] 685727002094 Uncharacterized conserved protein [Function unknown]; Region: COG1434 685727002095 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 685727002096 putative active site [active] 685727002097 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 685727002098 Ligand binding site; other site 685727002099 Ligand binding site; other site 685727002100 Ligand binding site; other site 685727002101 Putative Catalytic site; other site 685727002102 DXD motif; other site 685727002103 GtrA-like protein; Region: GtrA; pfam04138 685727002104 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 685727002105 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 685727002106 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 685727002107 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 685727002108 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 685727002109 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 685727002110 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 685727002111 aspartate aminotransferase; Provisional; Region: PRK05764 685727002112 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 685727002113 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685727002114 homodimer interface [polypeptide binding]; other site 685727002115 catalytic residue [active] 685727002116 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 685727002117 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727002118 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 685727002119 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 685727002120 tetramer interface [polypeptide binding]; other site 685727002121 Dienelactone hydrolase family; Region: DLH; pfam01738 685727002122 Transcriptional regulators [Transcription]; Region: MarR; COG1846 685727002123 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 685727002124 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 685727002125 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685727002126 Walker A/P-loop; other site 685727002127 ATP binding site [chemical binding]; other site 685727002128 Q-loop/lid; other site 685727002129 ABC transporter signature motif; other site 685727002130 Walker B; other site 685727002131 D-loop; other site 685727002132 H-loop/switch region; other site 685727002133 hypothetical protein; Validated; Region: PRK07121 685727002134 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 685727002135 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 685727002136 Cytochrome P450; Region: p450; cl12078 685727002137 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 685727002138 HIT family signature motif; other site 685727002139 catalytic residue [active] 685727002140 D-cysteine desulfhydrase; Validated; Region: PRK03910 685727002141 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 685727002142 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 685727002143 catalytic residue [active] 685727002144 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 685727002145 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 685727002146 3-oxo-5-alpha-steroid 4-dehydrogenase; Region: Steroid_dh; cl17474 685727002147 Rdx family; Region: Rdx; cl01407 685727002148 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 685727002149 dimer interface [polypeptide binding]; other site 685727002150 [2Fe-2S] cluster binding site [ion binding]; other site 685727002151 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 685727002152 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 685727002153 Walker A/P-loop; other site 685727002154 ATP binding site [chemical binding]; other site 685727002155 Q-loop/lid; other site 685727002156 ABC transporter signature motif; other site 685727002157 Walker B; other site 685727002158 D-loop; other site 685727002159 H-loop/switch region; other site 685727002160 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 685727002161 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 685727002162 dimer interface [polypeptide binding]; other site 685727002163 putative PBP binding regions; other site 685727002164 ABC-ATPase subunit interface; other site 685727002165 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 685727002166 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 685727002167 intersubunit interface [polypeptide binding]; other site 685727002168 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 685727002169 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 685727002170 intersubunit interface [polypeptide binding]; other site 685727002171 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 685727002172 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727002173 putative substrate translocation pore; other site 685727002174 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 685727002175 ATP binding site [chemical binding]; other site 685727002176 active site 685727002177 substrate binding site [chemical binding]; other site 685727002178 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 685727002179 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 685727002180 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 685727002181 Isochorismatase family; Region: Isochorismatase; pfam00857 685727002182 catalytic triad [active] 685727002183 conserved cis-peptide bond; other site 685727002184 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 685727002185 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 685727002186 acyl-activating enzyme (AAE) consensus motif; other site 685727002187 active site 685727002188 AMP binding site [chemical binding]; other site 685727002189 substrate binding site [chemical binding]; other site 685727002190 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727002191 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316 685727002192 NAD(P) binding site [chemical binding]; other site 685727002193 active site 685727002194 isochorismate synthase DhbC; Validated; Region: PRK06923 685727002195 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 685727002196 Condensation domain; Region: Condensation; pfam00668 685727002197 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 685727002198 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 685727002199 acyl-activating enzyme (AAE) consensus motif; other site 685727002200 AMP binding site [chemical binding]; other site 685727002201 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 685727002202 Condensation domain; Region: Condensation; pfam00668 685727002203 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 685727002204 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 685727002205 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 685727002206 acyl-activating enzyme (AAE) consensus motif; other site 685727002207 AMP binding site [chemical binding]; other site 685727002208 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 685727002209 Condensation domain; Region: Condensation; pfam00668 685727002210 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 685727002211 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 685727002212 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 685727002213 intersubunit interface [polypeptide binding]; other site 685727002214 Condensation domain; Region: Condensation; pfam00668 685727002215 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 685727002216 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 685727002217 acyl-activating enzyme (AAE) consensus motif; other site 685727002218 AMP binding site [chemical binding]; other site 685727002219 Condensation domain; Region: Condensation; pfam00668 685727002220 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 685727002221 Condensation domain; Region: Condensation; pfam00668 685727002222 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 685727002223 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 685727002224 acyl-activating enzyme (AAE) consensus motif; other site 685727002225 AMP binding site [chemical binding]; other site 685727002226 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 685727002227 Condensation domain; Region: Condensation; pfam00668 685727002228 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 685727002229 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 685727002230 enterobactin exporter EntS; Provisional; Region: PRK10489 685727002231 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 685727002232 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 685727002233 FAD binding pocket [chemical binding]; other site 685727002234 FAD binding motif [chemical binding]; other site 685727002235 phosphate binding motif [ion binding]; other site 685727002236 NAD binding pocket [chemical binding]; other site 685727002237 O-methyltransferase; Region: Methyltransf_2; pfam00891 685727002238 metabolite-proton symporter; Region: 2A0106; TIGR00883 685727002239 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727002240 putative substrate translocation pore; other site 685727002241 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 685727002242 catalytic residues [active] 685727002243 dimer interface [polypeptide binding]; other site 685727002244 Predicted deacetylase [General function prediction only]; Region: COG3233 685727002245 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 685727002246 putative active site [active] 685727002247 putative Zn binding site [ion binding]; other site 685727002248 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727002249 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 685727002250 putative dimer interface [polypeptide binding]; other site 685727002251 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 685727002252 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 685727002253 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 685727002254 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 685727002255 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 685727002256 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 685727002257 putative active site [active] 685727002258 catalytic triad [active] 685727002259 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 685727002260 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685727002261 active site 685727002262 phosphorylation site [posttranslational modification] 685727002263 intermolecular recognition site; other site 685727002264 dimerization interface [polypeptide binding]; other site 685727002265 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 685727002266 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685727002267 ATP binding site [chemical binding]; other site 685727002268 Mg2+ binding site [ion binding]; other site 685727002269 G-X-G motif; other site 685727002270 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 685727002271 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 685727002272 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 685727002273 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 685727002274 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 685727002275 Uncharacterized conserved protein [Function unknown]; Region: COG2128 685727002276 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 685727002277 active site 685727002278 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 685727002279 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 685727002280 active site 685727002281 metal binding site [ion binding]; metal-binding site 685727002282 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 685727002283 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 685727002284 dimerization interface [polypeptide binding]; other site 685727002285 ATP binding site [chemical binding]; other site 685727002286 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 685727002287 dimerization interface [polypeptide binding]; other site 685727002288 ATP binding site [chemical binding]; other site 685727002289 Predicted membrane protein [Function unknown]; Region: COG4425 685727002290 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 685727002291 CAAX protease self-immunity; Region: Abi; pfam02517 685727002292 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 685727002293 amidophosphoribosyltransferase; Provisional; Region: PRK07847 685727002294 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 685727002295 active site 685727002296 tetramer interface [polypeptide binding]; other site 685727002297 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 685727002298 active site 685727002299 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 685727002300 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 685727002301 dimerization interface [polypeptide binding]; other site 685727002302 putative ATP binding site [chemical binding]; other site 685727002303 L-asparaginase II; Region: Asparaginase_II; pfam06089 685727002304 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 685727002305 MOSC domain; Region: MOSC; pfam03473 685727002306 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 685727002307 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 685727002308 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 685727002309 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 685727002310 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 685727002311 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685727002312 catalytic residue [active] 685727002313 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 685727002314 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 685727002315 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 685727002316 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 685727002317 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 685727002318 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 685727002319 Walker A/P-loop; other site 685727002320 ATP binding site [chemical binding]; other site 685727002321 Q-loop/lid; other site 685727002322 ABC transporter signature motif; other site 685727002323 Walker B; other site 685727002324 D-loop; other site 685727002325 H-loop/switch region; other site 685727002326 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 685727002327 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685727002328 Walker A/P-loop; other site 685727002329 ATP binding site [chemical binding]; other site 685727002330 Q-loop/lid; other site 685727002331 ABC transporter signature motif; other site 685727002332 Walker B; other site 685727002333 D-loop; other site 685727002334 H-loop/switch region; other site 685727002335 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 685727002336 heme-binding site [chemical binding]; other site 685727002337 Cutinase; Region: Cutinase; pfam01083 685727002338 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 685727002339 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 685727002340 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 685727002341 active site residue [active] 685727002342 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 685727002343 active site residue [active] 685727002344 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 685727002345 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 685727002346 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 685727002347 catalytic residues [active] 685727002348 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 685727002349 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 685727002350 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 685727002351 DNA binding site [nucleotide binding] 685727002352 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 685727002353 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 685727002354 Coenzyme A binding pocket [chemical binding]; other site 685727002355 PBP superfamily domain; Region: PBP_like_2; cl17296 685727002356 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 685727002357 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685727002358 dimer interface [polypeptide binding]; other site 685727002359 conserved gate region; other site 685727002360 putative PBP binding loops; other site 685727002361 ABC-ATPase subunit interface; other site 685727002362 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 685727002363 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685727002364 dimer interface [polypeptide binding]; other site 685727002365 conserved gate region; other site 685727002366 putative PBP binding loops; other site 685727002367 ABC-ATPase subunit interface; other site 685727002368 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 685727002369 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 685727002370 Walker A/P-loop; other site 685727002371 ATP binding site [chemical binding]; other site 685727002372 Q-loop/lid; other site 685727002373 ABC transporter signature motif; other site 685727002374 Walker B; other site 685727002375 D-loop; other site 685727002376 H-loop/switch region; other site 685727002377 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 685727002378 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 685727002379 NAD binding site [chemical binding]; other site 685727002380 catalytic Zn binding site [ion binding]; other site 685727002381 substrate binding site [chemical binding]; other site 685727002382 structural Zn binding site [ion binding]; other site 685727002383 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 685727002384 putative catalytic site [active] 685727002385 putative metal binding site [ion binding]; other site 685727002386 putative phosphate binding site [ion binding]; other site 685727002387 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 685727002388 PhoU domain; Region: PhoU; pfam01895 685727002389 PhoU domain; Region: PhoU; pfam01895 685727002390 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 685727002391 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 685727002392 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 685727002393 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 685727002394 FMN binding site [chemical binding]; other site 685727002395 active site 685727002396 catalytic residues [active] 685727002397 substrate binding site [chemical binding]; other site 685727002398 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 685727002399 homodimer interface [polypeptide binding]; other site 685727002400 putative substrate binding pocket [chemical binding]; other site 685727002401 diiron center [ion binding]; other site 685727002402 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685727002403 Transcriptional regulator [Transcription]; Region: LysR; COG0583 685727002404 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 685727002405 putative dimerization interface [polypeptide binding]; other site 685727002406 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727002407 Major Facilitator Superfamily; Region: MFS_1; pfam07690 685727002408 putative substrate translocation pore; other site 685727002409 Protein of unknown function (DUF419); Region: DUF419; pfam04237 685727002410 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 685727002411 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 685727002412 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 685727002413 oligomer interface [polypeptide binding]; other site 685727002414 metal binding site [ion binding]; metal-binding site 685727002415 metal binding site [ion binding]; metal-binding site 685727002416 putative Cl binding site [ion binding]; other site 685727002417 aspartate ring; other site 685727002418 basic sphincter; other site 685727002419 hydrophobic gate; other site 685727002420 periplasmic entrance; other site 685727002421 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727002422 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727002423 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 685727002424 Transcriptional regulator [Transcription]; Region: IclR; COG1414 685727002425 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727002426 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727002427 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 685727002428 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 685727002429 Flavin binding site [chemical binding]; other site 685727002430 hypothetical protein; Validated; Region: PRK07121 685727002431 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 685727002432 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727002433 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 685727002434 classical (c) SDRs; Region: SDR_c; cd05233 685727002435 NAD(P) binding site [chemical binding]; other site 685727002436 active site 685727002437 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 685727002438 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 685727002439 probable active site [active] 685727002440 Putative esterase; Region: Esterase; pfam00756 685727002441 S-formylglutathione hydrolase; Region: PLN02442 685727002442 short chain dehydrogenase; Provisional; Region: PRK06197 685727002443 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 685727002444 putative NAD(P) binding site [chemical binding]; other site 685727002445 active site 685727002446 The single-domain 2,3-dihydroxybiphenyl 1,2-dioxygenases (BphC, EC 1.13.11.39) from Rhodococcus globerulus P6, BphC2-RGP6 and BphC3-RGP6, and similar proteins; Region: BphC2-C3-RGP6_C_like; cd08348 685727002447 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 685727002448 putative active site [active] 685727002449 putative metal binding site [ion binding]; other site 685727002450 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727002451 Major Facilitator Superfamily; Region: MFS_1; pfam07690 685727002452 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 685727002453 Clp amino terminal domain; Region: Clp_N; pfam02861 685727002454 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685727002455 Walker A motif; other site 685727002456 ATP binding site [chemical binding]; other site 685727002457 Walker B motif; other site 685727002458 arginine finger; other site 685727002459 UvrB/uvrC motif; Region: UVR; pfam02151 685727002460 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685727002461 Walker A motif; other site 685727002462 ATP binding site [chemical binding]; other site 685727002463 Walker B motif; other site 685727002464 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 685727002465 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727002466 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727002467 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 685727002468 classical (c) SDRs; Region: SDR_c; cd05233 685727002469 NAD(P) binding site [chemical binding]; other site 685727002470 active site 685727002471 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 685727002472 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 685727002473 iron-sulfur cluster [ion binding]; other site 685727002474 [2Fe-2S] cluster binding site [ion binding]; other site 685727002475 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 685727002476 hydrophobic ligand binding site; other site 685727002477 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 685727002478 Transcriptional regulator [Transcription]; Region: IclR; COG1414 685727002479 Bacterial transcriptional regulator; Region: IclR; pfam01614 685727002480 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 685727002481 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727002482 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 685727002483 citrate synthase; Provisional; Region: PRK14033 685727002484 Cold-active citrate synthase (CS) from an Antarctic bacterial strain DS2-3R (Ds)-like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or...; Region: DsCS_like; cd06111 685727002485 dimer interface [polypeptide binding]; other site 685727002486 active site 685727002487 citrylCoA binding site [chemical binding]; other site 685727002488 oxalacetate/citrate binding site [chemical binding]; other site 685727002489 coenzyme A binding site [chemical binding]; other site 685727002490 catalytic triad [active] 685727002491 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 685727002492 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 685727002493 tetramer interface [polypeptide binding]; other site 685727002494 active site 685727002495 Mg2+/Mn2+ binding site [ion binding]; other site 685727002496 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 685727002497 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 685727002498 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 685727002499 sequence-specific DNA binding site [nucleotide binding]; other site 685727002500 salt bridge; other site 685727002501 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 685727002502 Domain of unknown function (DUF955); Region: DUF955; pfam06114 685727002503 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 685727002504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727002505 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 685727002506 putative substrate translocation pore; other site 685727002507 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 685727002508 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 685727002509 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 685727002510 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 685727002511 THF binding site; other site 685727002512 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 685727002513 substrate binding site [chemical binding]; other site 685727002514 THF binding site; other site 685727002515 zinc-binding site [ion binding]; other site 685727002516 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 685727002517 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 685727002518 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 685727002519 putative active site [active] 685727002520 putative substrate binding site [chemical binding]; other site 685727002521 ATP binding site [chemical binding]; other site 685727002522 Phosphotransferase enzyme family; Region: APH; pfam01636 685727002523 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 685727002524 Cytochrome P450; Region: p450; cl12078 685727002525 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727002526 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727002527 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 685727002528 putative FMN binding site [chemical binding]; other site 685727002529 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 685727002530 putative hydrophobic ligand binding site [chemical binding]; other site 685727002531 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 685727002532 dimerization interface [polypeptide binding]; other site 685727002533 putative DNA binding site [nucleotide binding]; other site 685727002534 putative Zn2+ binding site [ion binding]; other site 685727002535 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 685727002536 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 685727002537 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 685727002538 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 685727002539 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727002540 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727002541 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 685727002542 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685727002543 active site 685727002544 phosphorylation site [posttranslational modification] 685727002545 intermolecular recognition site; other site 685727002546 dimerization interface [polypeptide binding]; other site 685727002547 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 685727002548 CHASE3 domain; Region: CHASE3; pfam05227 685727002549 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 685727002550 dimer interface [polypeptide binding]; other site 685727002551 phosphorylation site [posttranslational modification] 685727002552 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685727002553 ATP binding site [chemical binding]; other site 685727002554 Mg2+ binding site [ion binding]; other site 685727002555 G-X-G motif; other site 685727002556 Response regulator receiver domain; Region: Response_reg; pfam00072 685727002557 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685727002558 active site 685727002559 phosphorylation site [posttranslational modification] 685727002560 intermolecular recognition site; other site 685727002561 dimerization interface [polypeptide binding]; other site 685727002562 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 685727002563 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 685727002564 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 685727002565 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 685727002566 putative active site [active] 685727002567 putative active site [active] 685727002568 catalytic site [active] 685727002569 catalytic site [active] 685727002570 Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105 685727002571 putative active site [active] 685727002572 catalytic site [active] 685727002573 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 685727002574 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 685727002575 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 685727002576 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 685727002577 DNA binding residues [nucleotide binding] 685727002578 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 685727002579 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 685727002580 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 685727002581 anti sigma factor interaction site; other site 685727002582 regulatory phosphorylation site [posttranslational modification]; other site 685727002583 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 685727002584 Transcriptional regulator; Region: Rrf2; cl17282 685727002585 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 685727002586 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685727002587 aminotransferase; Validated; Region: PRK07777 685727002588 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 685727002589 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685727002590 homodimer interface [polypeptide binding]; other site 685727002591 catalytic residue [active] 685727002592 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 685727002593 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 685727002594 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 685727002595 Protein of unknown function (DUF422); Region: DUF422; cl00991 685727002596 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 685727002597 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 685727002598 active site 685727002599 phytoene desaturase; Region: crtI_fam; TIGR02734 685727002600 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 685727002601 active site lid residues [active] 685727002602 substrate binding pocket [chemical binding]; other site 685727002603 catalytic residues [active] 685727002604 substrate-Mg2+ binding site; other site 685727002605 aspartate-rich region 1; other site 685727002606 aspartate-rich region 2; other site 685727002607 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 685727002608 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 685727002609 active site 685727002610 metal binding site [ion binding]; metal-binding site 685727002611 nudix motif; other site 685727002612 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 685727002613 mce related protein; Region: MCE; pfam02470 685727002614 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 685727002615 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 685727002616 active site 685727002617 homotetramer interface [polypeptide binding]; other site 685727002618 Protein of unknown function (DUF3239); Region: DUF3239; pfam11580 685727002619 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 685727002620 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 685727002621 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 685727002622 putative Mg++ binding site [ion binding]; other site 685727002623 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 685727002624 nucleotide binding region [chemical binding]; other site 685727002625 ATP-binding site [chemical binding]; other site 685727002626 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 685727002627 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 685727002628 hypothetical protein; Provisional; Region: PRK11770 685727002629 Domain of unknown function (DUF307); Region: DUF307; pfam03733 685727002630 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 685727002631 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 685727002632 Catalytic site [active] 685727002633 alternate signal-mediated exported protein, RER_14450 family; Region: exp_by_SipW_III; TIGR04089 685727002634 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 685727002635 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 685727002636 Catalytic site [active] 685727002637 alternate signal-mediated exported protein, RER_14450 family; Region: exp_by_SipW_III; TIGR04089 685727002638 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 685727002639 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 685727002640 PYR/PP interface [polypeptide binding]; other site 685727002641 dimer interface [polypeptide binding]; other site 685727002642 TPP binding site [chemical binding]; other site 685727002643 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 685727002644 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 685727002645 TPP-binding site [chemical binding]; other site 685727002646 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 685727002647 Homoserine O-succinyltransferase; Region: HTS; pfam04204 685727002648 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 685727002649 proposed active site lysine [active] 685727002650 conserved cys residue [active] 685727002651 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 685727002652 DNA-binding site [nucleotide binding]; DNA binding site 685727002653 RNA-binding motif; other site 685727002654 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 685727002655 H+ Antiporter protein; Region: 2A0121; TIGR00900 685727002656 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 685727002657 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 685727002658 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 685727002659 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 685727002660 active site 685727002661 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 685727002662 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 685727002663 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 685727002664 MarR family; Region: MarR; pfam01047 685727002665 H+ Antiporter protein; Region: 2A0121; TIGR00900 685727002666 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727002667 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 685727002668 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727002669 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 685727002670 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 685727002671 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 685727002672 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 685727002673 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 685727002674 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 685727002675 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 685727002676 catalytic residue [active] 685727002677 citrate synthase 2; Provisional; Region: PRK12350 685727002678 Citrate synthase; Region: Citrate_synt; pfam00285 685727002679 oxalacetate binding site [chemical binding]; other site 685727002680 citrylCoA binding site [chemical binding]; other site 685727002681 coenzyme A binding site [chemical binding]; other site 685727002682 catalytic triad [active] 685727002683 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 685727002684 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 685727002685 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 685727002686 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727002687 putative substrate translocation pore; other site 685727002688 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 685727002689 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 685727002690 putative substrate binding site [chemical binding]; other site 685727002691 putative ATP binding site [chemical binding]; other site 685727002692 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 685727002693 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 685727002694 dimer interface [polypeptide binding]; other site 685727002695 active site 685727002696 citrylCoA binding site [chemical binding]; other site 685727002697 NADH binding [chemical binding]; other site 685727002698 cationic pore residues; other site 685727002699 oxalacetate/citrate binding site [chemical binding]; other site 685727002700 coenzyme A binding site [chemical binding]; other site 685727002701 catalytic triad [active] 685727002702 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 685727002703 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 685727002704 Putative esterase; Region: Esterase; pfam00756 685727002705 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 685727002706 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 685727002707 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 685727002708 phosphorylation site [posttranslational modification] 685727002709 dimer interface [polypeptide binding]; other site 685727002710 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685727002711 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 685727002712 active site 685727002713 phosphorylation site [posttranslational modification] 685727002714 intermolecular recognition site; other site 685727002715 dimerization interface [polypeptide binding]; other site 685727002716 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 685727002717 DNA binding site [nucleotide binding] 685727002718 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 685727002719 MarR family; Region: MarR; pfam01047 685727002720 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 685727002721 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 685727002722 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 685727002723 DNA-binding site [nucleotide binding]; DNA binding site 685727002724 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 685727002725 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 685727002726 DNA photolyase; Region: DNA_photolyase; pfam00875 685727002727 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 685727002728 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 685727002729 active site 685727002730 FMN binding site [chemical binding]; other site 685727002731 substrate binding site [chemical binding]; other site 685727002732 putative catalytic residue [active] 685727002733 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 685727002734 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 685727002735 acyl-activating enzyme (AAE) consensus motif; other site 685727002736 putative AMP binding site [chemical binding]; other site 685727002737 putative active site [active] 685727002738 putative CoA binding site [chemical binding]; other site 685727002739 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 685727002740 A new structural DNA glycosylase; Region: AlkD_like; cd06561 685727002741 active site 685727002742 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 685727002743 GAF domain; Region: GAF_2; pfam13185 685727002744 ANTAR domain; Region: ANTAR; pfam03861 685727002745 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 685727002746 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 685727002747 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 685727002748 DNA binding residues [nucleotide binding] 685727002749 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 685727002750 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 685727002751 Prostaglandin dehydrogenases; Region: PGDH; cd05288 685727002752 NAD(P) binding site [chemical binding]; other site 685727002753 substrate binding site [chemical binding]; other site 685727002754 dimer interface [polypeptide binding]; other site 685727002755 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 685727002756 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727002757 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727002758 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 685727002759 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 685727002760 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 685727002761 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 685727002762 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 685727002763 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685727002764 Walker A/P-loop; other site 685727002765 ATP binding site [chemical binding]; other site 685727002766 Q-loop/lid; other site 685727002767 ABC transporter signature motif; other site 685727002768 Walker B; other site 685727002769 D-loop; other site 685727002770 H-loop/switch region; other site 685727002771 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 685727002772 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 685727002773 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 685727002774 non-specific DNA binding site [nucleotide binding]; other site 685727002775 salt bridge; other site 685727002776 sequence-specific DNA binding site [nucleotide binding]; other site 685727002777 Protein of unknown function (DUF461); Region: DUF461; pfam04314 685727002778 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 685727002779 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 685727002780 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 685727002781 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685727002782 D-loop; other site 685727002783 H-loop/switch region; other site 685727002784 ABC transporter; Region: ABC_tran_2; pfam12848 685727002785 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 685727002786 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727002787 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727002788 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 685727002789 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 685727002790 enoyl-CoA hydratase; Provisional; Region: PRK08260 685727002791 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 685727002792 substrate binding site [chemical binding]; other site 685727002793 oxyanion hole (OAH) forming residues; other site 685727002794 trimer interface [polypeptide binding]; other site 685727002795 short chain dehydrogenase; Provisional; Region: PRK06197 685727002796 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727002797 NAD(P) binding site [chemical binding]; other site 685727002798 active site 685727002799 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727002800 short chain dehydrogenase; Provisional; Region: PRK07454 685727002801 NAD(P) binding site [chemical binding]; other site 685727002802 active site 685727002803 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 685727002804 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727002805 NAD(P) binding site [chemical binding]; other site 685727002806 active site 685727002807 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12845 685727002808 Predicted oxidoreductase [General function prediction only]; Region: COG3573 685727002809 Methyltransferase domain; Region: Methyltransf_31; pfam13847 685727002810 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685727002811 S-adenosylmethionine binding site [chemical binding]; other site 685727002812 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 685727002813 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 685727002814 active site 685727002815 catalytic tetrad [active] 685727002816 Predicted transcriptional regulators [Transcription]; Region: COG1695 685727002817 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 685727002818 Major Facilitator Superfamily; Region: MFS_1; pfam07690 685727002819 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727002820 putative substrate translocation pore; other site 685727002821 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727002822 Predicted ATPase [General function prediction only]; Region: COG1485 685727002823 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727002824 Domain of unknown function (DUF222); Region: DUF222; pfam02720 685727002825 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 685727002826 active site 685727002827 lumazine synthase and riboflavin synthase; involved in the riboflavin (vitamin B2) biosynthetic pathway; Region: Lumazine_synthase-like; cl00317 685727002828 homopentamer interface [polypeptide binding]; other site 685727002829 active site 685727002830 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 685727002831 Uncharacterized conserved protein [Function unknown]; Region: COG5361 685727002832 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 685727002833 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 685727002834 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 685727002835 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 685727002836 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 685727002837 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 685727002838 substrate binding site [chemical binding]; other site 685727002839 oxyanion hole (OAH) forming residues; other site 685727002840 trimer interface [polypeptide binding]; other site 685727002841 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 685727002842 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 685727002843 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 685727002844 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 685727002845 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 685727002846 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 685727002847 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 685727002848 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 685727002849 Soluble P-type ATPase [General function prediction only]; Region: COG4087 685727002850 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727002851 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727002852 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 685727002853 CoenzymeA binding site [chemical binding]; other site 685727002854 subunit interaction site [polypeptide binding]; other site 685727002855 PHB binding site; other site 685727002856 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 685727002857 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 685727002858 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 685727002859 Secretory lipase; Region: LIP; pfam03583 685727002860 Histidine kinase; Region: His_kinase; pfam06580 685727002861 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685727002862 ATP binding site [chemical binding]; other site 685727002863 Mg2+ binding site [ion binding]; other site 685727002864 G-X-G motif; other site 685727002865 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 685727002866 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685727002867 active site 685727002868 phosphorylation site [posttranslational modification] 685727002869 intermolecular recognition site; other site 685727002870 dimerization interface [polypeptide binding]; other site 685727002871 LytTr DNA-binding domain; Region: LytTR; smart00850 685727002872 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 685727002873 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 685727002874 Na binding site [ion binding]; other site 685727002875 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 685727002876 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 685727002877 iron-sulfur cluster [ion binding]; other site 685727002878 [2Fe-2S] cluster binding site [ion binding]; other site 685727002879 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 685727002880 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 685727002881 active site 685727002882 putative substrate binding pocket [chemical binding]; other site 685727002883 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 685727002884 Protein of unknown function, DUF485; Region: DUF485; pfam04341 685727002885 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 685727002886 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 685727002887 Na binding site [ion binding]; other site 685727002888 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 685727002889 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 685727002890 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 685727002891 metal ion-dependent adhesion site (MIDAS); other site 685727002892 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 685727002893 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 685727002894 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727002895 D-galactonate transporter; Region: 2A0114; TIGR00893 685727002896 putative substrate translocation pore; other site 685727002897 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 685727002898 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 685727002899 PCI domain; Region: PCI; cl02111 685727002900 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 685727002901 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685727002902 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 685727002903 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 685727002904 NADP binding site [chemical binding]; other site 685727002905 dimer interface [polypeptide binding]; other site 685727002906 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 685727002907 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 685727002908 substrate binding pocket [chemical binding]; other site 685727002909 active site 685727002910 iron coordination sites [ion binding]; other site 685727002911 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 685727002912 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 685727002913 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 685727002914 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 685727002915 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 685727002916 acyl-activating enzyme (AAE) consensus motif; other site 685727002917 putative AMP binding site [chemical binding]; other site 685727002918 putative active site [active] 685727002919 putative CoA binding site [chemical binding]; other site 685727002920 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 685727002921 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727002922 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727002923 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 685727002924 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 685727002925 active site 685727002926 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 685727002927 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 685727002928 substrate binding pocket [chemical binding]; other site 685727002929 membrane-bound complex binding site; other site 685727002930 hinge residues; other site 685727002931 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 685727002932 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 685727002933 nucleotide binding site [chemical binding]; other site 685727002934 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 685727002935 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 685727002936 active site 685727002937 DNA binding site [nucleotide binding] 685727002938 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 685727002939 DNA binding site [nucleotide binding] 685727002940 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 685727002941 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 685727002942 DNA binding residues [nucleotide binding] 685727002943 putative dimer interface [polypeptide binding]; other site 685727002944 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 685727002945 active site 2 [active] 685727002946 active site 1 [active] 685727002947 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 685727002948 active site 685727002949 catalytic site [active] 685727002950 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 685727002951 Peptidase family M23; Region: Peptidase_M23; pfam01551 685727002952 Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454 685727002953 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 685727002954 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 685727002955 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 685727002956 heme-binding site [chemical binding]; other site 685727002957 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 685727002958 FAD binding pocket [chemical binding]; other site 685727002959 FAD binding motif [chemical binding]; other site 685727002960 phosphate binding motif [ion binding]; other site 685727002961 beta-alpha-beta structure motif; other site 685727002962 NAD binding pocket [chemical binding]; other site 685727002963 Heme binding pocket [chemical binding]; other site 685727002964 Rrf2 family protein; Region: rrf2_super; TIGR00738 685727002965 Transcriptional regulator; Region: Rrf2; cl17282 685727002966 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 685727002967 Ligand Binding Site [chemical binding]; other site 685727002968 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 685727002969 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 685727002970 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 685727002971 Ligand Binding Site [chemical binding]; other site 685727002972 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 685727002973 Ligand Binding Site [chemical binding]; other site 685727002974 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 685727002975 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 685727002976 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 685727002977 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 685727002978 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 685727002979 rod shape-determining protein MreB; Provisional; Region: PRK13930 685727002980 MreB and similar proteins; Region: MreB_like; cd10225 685727002981 nucleotide binding site [chemical binding]; other site 685727002982 Mg binding site [ion binding]; other site 685727002983 putative protofilament interaction site [polypeptide binding]; other site 685727002984 RodZ interaction site [polypeptide binding]; other site 685727002985 heat shock protein 90; Provisional; Region: PRK05218 685727002986 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685727002987 ATP binding site [chemical binding]; other site 685727002988 Mg2+ binding site [ion binding]; other site 685727002989 G-X-G motif; other site 685727002990 AAA ATPase domain; Region: AAA_16; pfam13191 685727002991 Predicted ATPase [General function prediction only]; Region: COG3903 685727002992 Tetratricopeptide repeat; Region: TPR_12; pfam13424 685727002993 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 685727002994 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 685727002995 DNA binding residues [nucleotide binding] 685727002996 dimerization interface [polypeptide binding]; other site 685727002997 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 685727002998 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 685727002999 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685727003000 active site 685727003001 phosphorylation site [posttranslational modification] 685727003002 intermolecular recognition site; other site 685727003003 dimerization interface [polypeptide binding]; other site 685727003004 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 685727003005 DNA binding residues [nucleotide binding] 685727003006 dimerization interface [polypeptide binding]; other site 685727003007 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 685727003008 GAF domain; Region: GAF_2; pfam13185 685727003009 GAF domain; Region: GAF_3; pfam13492 685727003010 Histidine kinase; Region: HisKA_3; pfam07730 685727003011 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685727003012 ATP binding site [chemical binding]; other site 685727003013 Mg2+ binding site [ion binding]; other site 685727003014 G-X-G motif; other site 685727003015 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727003016 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727003017 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 685727003018 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 685727003019 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 685727003020 folate binding site [chemical binding]; other site 685727003021 NADP+ binding site [chemical binding]; other site 685727003022 thymidylate synthase; Reviewed; Region: thyA; PRK01827 685727003023 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 685727003024 dimerization interface [polypeptide binding]; other site 685727003025 active site 685727003026 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 685727003027 active site 685727003028 SAM binding site [chemical binding]; other site 685727003029 homodimer interface [polypeptide binding]; other site 685727003030 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 685727003031 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 685727003032 putative DNA binding site [nucleotide binding]; other site 685727003033 catalytic residue [active] 685727003034 putative H2TH interface [polypeptide binding]; other site 685727003035 putative catalytic residues [active] 685727003036 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 685727003037 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 685727003038 GtrA-like protein; Region: GtrA; pfam04138 685727003039 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 685727003040 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 685727003041 substrate binding pocket [chemical binding]; other site 685727003042 catalytic triad [active] 685727003043 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 685727003044 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 685727003045 substrate binding pocket [chemical binding]; other site 685727003046 catalytic triad [active] 685727003047 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 685727003048 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 685727003049 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 685727003050 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 685727003051 acyl-activating enzyme (AAE) consensus motif; other site 685727003052 acyl-activating enzyme (AAE) consensus motif; other site 685727003053 putative AMP binding site [chemical binding]; other site 685727003054 putative active site [active] 685727003055 putative CoA binding site [chemical binding]; other site 685727003056 RES domain; Region: RES; pfam08808 685727003057 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685727003058 S-adenosylmethionine binding site [chemical binding]; other site 685727003059 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 685727003060 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 685727003061 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 685727003062 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 685727003063 ABC-2 type transporter; Region: ABC2_membrane; cl17235 685727003064 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685727003065 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 685727003066 Walker A/P-loop; other site 685727003067 ATP binding site [chemical binding]; other site 685727003068 Q-loop/lid; other site 685727003069 ABC transporter signature motif; other site 685727003070 Walker B; other site 685727003071 D-loop; other site 685727003072 H-loop/switch region; other site 685727003073 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 685727003074 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 685727003075 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 685727003076 substrate binding site [chemical binding]; other site 685727003077 oxyanion hole (OAH) forming residues; other site 685727003078 trimer interface [polypeptide binding]; other site 685727003079 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 685727003080 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 685727003081 active site 685727003082 dimer interface [polypeptide binding]; other site 685727003083 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 685727003084 dimer interface [polypeptide binding]; other site 685727003085 active site 685727003086 succinic semialdehyde dehydrogenase; Region: PLN02278 685727003087 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 685727003088 tetramerization interface [polypeptide binding]; other site 685727003089 NAD(P) binding site [chemical binding]; other site 685727003090 catalytic residues [active] 685727003091 hypothetical protein; Provisional; Region: PRK07857 685727003092 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 685727003093 Part of AAA domain; Region: AAA_19; pfam13245 685727003094 Family description; Region: UvrD_C_2; pfam13538 685727003095 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 685727003096 Peptidase family M23; Region: Peptidase_M23; pfam01551 685727003097 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 685727003098 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 685727003099 CoA-ligase; Region: Ligase_CoA; pfam00549 685727003100 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 685727003101 CoA binding domain; Region: CoA_binding; smart00881 685727003102 CoA-ligase; Region: Ligase_CoA; pfam00549 685727003103 Uncharacterized conserved protein [Function unknown]; Region: COG1739 685727003104 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 685727003105 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 685727003106 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 685727003107 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 685727003108 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 685727003109 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 685727003110 active site 685727003111 substrate binding site [chemical binding]; other site 685727003112 cosubstrate binding site; other site 685727003113 catalytic site [active] 685727003114 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 685727003115 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 685727003116 purine monophosphate binding site [chemical binding]; other site 685727003117 dimer interface [polypeptide binding]; other site 685727003118 putative catalytic residues [active] 685727003119 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 685727003120 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 685727003121 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 685727003122 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 685727003123 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 685727003124 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 685727003125 metal ion-dependent adhesion site (MIDAS); other site 685727003126 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 685727003127 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 685727003128 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 685727003129 dimerization interface [polypeptide binding]; other site 685727003130 putative DNA binding site [nucleotide binding]; other site 685727003131 putative Zn2+ binding site [ion binding]; other site 685727003132 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 685727003133 Amidase; Region: Amidase; pfam01425 685727003134 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 685727003135 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 685727003136 DNA binding residues [nucleotide binding] 685727003137 Predicted permeases [General function prediction only]; Region: COG0679 685727003138 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 685727003139 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 685727003140 DNA binding residues [nucleotide binding] 685727003141 putative dimer interface [polypeptide binding]; other site 685727003142 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 685727003143 Sulfatase; Region: Sulfatase; pfam00884 685727003144 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110 685727003145 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 685727003146 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 685727003147 Walker A/P-loop; other site 685727003148 ATP binding site [chemical binding]; other site 685727003149 Q-loop/lid; other site 685727003150 ABC transporter signature motif; other site 685727003151 Walker B; other site 685727003152 D-loop; other site 685727003153 H-loop/switch region; other site 685727003154 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 685727003155 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 685727003156 ABC-ATPase subunit interface; other site 685727003157 dimer interface [polypeptide binding]; other site 685727003158 putative PBP binding regions; other site 685727003159 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 685727003160 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 685727003161 intersubunit interface [polypeptide binding]; other site 685727003162 30S ribosomal protein S18; Provisional; Region: PRK13401 685727003163 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 685727003164 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 685727003165 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 685727003166 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 685727003167 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 685727003168 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 685727003169 Predicted membrane protein [Function unknown]; Region: COG2860 685727003170 UPF0126 domain; Region: UPF0126; pfam03458 685727003171 UPF0126 domain; Region: UPF0126; pfam03458 685727003172 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 685727003173 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685727003174 active site 685727003175 phosphorylation site [posttranslational modification] 685727003176 intermolecular recognition site; other site 685727003177 dimerization interface [polypeptide binding]; other site 685727003178 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 685727003179 DNA binding site [nucleotide binding] 685727003180 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 685727003181 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 685727003182 dimerization interface [polypeptide binding]; other site 685727003183 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 685727003184 dimer interface [polypeptide binding]; other site 685727003185 phosphorylation site [posttranslational modification] 685727003186 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685727003187 ATP binding site [chemical binding]; other site 685727003188 Mg2+ binding site [ion binding]; other site 685727003189 G-X-G motif; other site 685727003190 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 685727003191 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 685727003192 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 685727003193 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 685727003194 MPT binding site; other site 685727003195 trimer interface [polypeptide binding]; other site 685727003196 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 685727003197 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 685727003198 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 685727003199 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 685727003200 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 685727003201 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 685727003202 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 685727003203 active site 685727003204 tetramer interface; other site 685727003205 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 685727003206 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 685727003207 dimer interface [polypeptide binding]; other site 685727003208 putative functional site; other site 685727003209 putative MPT binding site; other site 685727003210 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 685727003211 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 685727003212 MspA; Region: MspA; pfam09203 685727003213 short chain dehydrogenase; Provisional; Region: PRK07832 685727003214 classical (c) SDRs; Region: SDR_c; cd05233 685727003215 NAD(P) binding site [chemical binding]; other site 685727003216 active site 685727003217 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 685727003218 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 685727003219 Walker A/P-loop; other site 685727003220 ATP binding site [chemical binding]; other site 685727003221 Q-loop/lid; other site 685727003222 ABC transporter signature motif; other site 685727003223 Walker B; other site 685727003224 D-loop; other site 685727003225 H-loop/switch region; other site 685727003226 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 685727003227 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 685727003228 Histidine kinase; Region: HisKA_3; pfam07730 685727003229 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685727003230 ATP binding site [chemical binding]; other site 685727003231 G-X-G motif; other site 685727003232 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 685727003233 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685727003234 active site 685727003235 phosphorylation site [posttranslational modification] 685727003236 intermolecular recognition site; other site 685727003237 dimerization interface [polypeptide binding]; other site 685727003238 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 685727003239 DNA binding residues [nucleotide binding] 685727003240 dimerization interface [polypeptide binding]; other site 685727003241 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 685727003242 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 685727003243 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 685727003244 DNA binding residues [nucleotide binding] 685727003245 dimer interface [polypeptide binding]; other site 685727003246 [2Fe-2S] cluster binding site [ion binding]; other site 685727003247 arginine deiminase; Provisional; Region: PRK01388 685727003248 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 685727003249 ArsC family; Region: ArsC; pfam03960 685727003250 catalytic residues [active] 685727003251 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 685727003252 NADH(P)-binding; Region: NAD_binding_10; pfam13460 685727003253 NAD(P) binding site [chemical binding]; other site 685727003254 putative active site [active] 685727003255 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 685727003256 DNA-binding site [nucleotide binding]; DNA binding site 685727003257 Predicted membrane protein [Function unknown]; Region: COG2259 685727003258 BCCT family transporter; Region: BCCT; pfam02028 685727003259 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 685727003260 active site 685727003261 catalytic site [active] 685727003262 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 685727003263 Predicted methyltransferases [General function prediction only]; Region: COG0313 685727003264 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 685727003265 putative homodimer interface [polypeptide binding]; other site 685727003266 putative SAM binding site [chemical binding]; other site 685727003267 AAA ATPase domain; Region: AAA_16; pfam13191 685727003268 AAA domain; Region: AAA_22; pfam13401 685727003269 FOG: WD40 repeat [General function prediction only]; Region: COG2319 685727003270 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 685727003271 structural tetrad; other site 685727003272 FOG: WD40 repeat [General function prediction only]; Region: COG2319 685727003273 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 685727003274 structural tetrad; other site 685727003275 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 685727003276 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 685727003277 chorismate binding enzyme; Region: Chorismate_bind; cl10555 685727003278 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 685727003279 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 685727003280 active site 685727003281 HIGH motif; other site 685727003282 KMSKS motif; other site 685727003283 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 685727003284 tRNA binding surface [nucleotide binding]; other site 685727003285 anticodon binding site; other site 685727003286 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 685727003287 active site 685727003288 Pirin-related protein [General function prediction only]; Region: COG1741 685727003289 Pirin; Region: Pirin; pfam02678 685727003290 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 685727003291 Domain of unknown function (DUF348); Region: DUF348; pfam03990 685727003292 Domain of unknown function (DUF348); Region: DUF348; pfam03990 685727003293 Domain of unknown function (DUF348); Region: DUF348; pfam03990 685727003294 G5 domain; Region: G5; pfam07501 685727003295 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 685727003296 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 685727003297 Domain of unknown function (DUF348); Region: DUF348; pfam03990 685727003298 Domain of unknown function (DUF348); Region: DUF348; pfam03990 685727003299 Domain of unknown function (DUF348); Region: DUF348; pfam03990 685727003300 G5 domain; Region: G5; pfam07501 685727003301 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 685727003302 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 685727003303 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 685727003304 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 685727003305 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 685727003306 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 685727003307 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 685727003308 metal-binding site [ion binding] 685727003309 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 685727003310 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 685727003311 metal-binding site [ion binding] 685727003312 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 685727003313 DNA-binding site [nucleotide binding]; DNA binding site 685727003314 RNA-binding motif; other site 685727003315 SnoaL-like domain; Region: SnoaL_4; pfam13577 685727003316 HTH domain; Region: HTH_11; pfam08279 685727003317 WYL domain; Region: WYL; pfam13280 685727003318 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 685727003319 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685727003320 Walker A/P-loop; other site 685727003321 ATP binding site [chemical binding]; other site 685727003322 Q-loop/lid; other site 685727003323 ABC transporter signature motif; other site 685727003324 Walker B; other site 685727003325 D-loop; other site 685727003326 H-loop/switch region; other site 685727003327 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 685727003328 ABC-2 type transporter; Region: ABC2_membrane; cl17235 685727003329 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 685727003330 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 685727003331 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 685727003332 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 685727003333 SnoaL-like domain; Region: SnoaL_4; pfam13577 685727003334 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 685727003335 putative dimer interface [polypeptide binding]; other site 685727003336 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 685727003337 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 685727003338 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 685727003339 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 685727003340 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 685727003341 substrate binding site [chemical binding]; other site 685727003342 oxyanion hole (OAH) forming residues; other site 685727003343 trimer interface [polypeptide binding]; other site 685727003344 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 685727003345 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 685727003346 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 685727003347 dimer interface [polypeptide binding]; other site 685727003348 phosphorylation site [posttranslational modification] 685727003349 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685727003350 ATP binding site [chemical binding]; other site 685727003351 Mg2+ binding site [ion binding]; other site 685727003352 G-X-G motif; other site 685727003353 Response regulator receiver domain; Region: Response_reg; pfam00072 685727003354 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685727003355 active site 685727003356 phosphorylation site [posttranslational modification] 685727003357 intermolecular recognition site; other site 685727003358 dimerization interface [polypeptide binding]; other site 685727003359 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 685727003360 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 685727003361 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 685727003362 active site 685727003363 catalytic tetrad [active] 685727003364 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 685727003365 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727003366 putative substrate translocation pore; other site 685727003367 MarR family; Region: MarR_2; cl17246 685727003368 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 685727003369 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 685727003370 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 685727003371 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 685727003372 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 685727003373 G1 box; other site 685727003374 putative GEF interaction site [polypeptide binding]; other site 685727003375 GTP/Mg2+ binding site [chemical binding]; other site 685727003376 Switch I region; other site 685727003377 G2 box; other site 685727003378 G3 box; other site 685727003379 Switch II region; other site 685727003380 G4 box; other site 685727003381 G5 box; other site 685727003382 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 685727003383 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 685727003384 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 685727003385 acyl-activating enzyme (AAE) consensus motif; other site 685727003386 active site 685727003387 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 685727003388 dimerization interface [polypeptide binding]; other site 685727003389 ATP binding site [chemical binding]; other site 685727003390 selenocysteine synthase; Provisional; Region: PRK04311 685727003391 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 685727003392 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 685727003393 catalytic residue [active] 685727003394 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 685727003395 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 685727003396 G1 box; other site 685727003397 putative GEF interaction site [polypeptide binding]; other site 685727003398 GTP/Mg2+ binding site [chemical binding]; other site 685727003399 Switch I region; other site 685727003400 G2 box; other site 685727003401 G3 box; other site 685727003402 Switch II region; other site 685727003403 G4 box; other site 685727003404 G5 box; other site 685727003405 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 685727003406 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 685727003407 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 685727003408 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 685727003409 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 685727003410 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 685727003411 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 685727003412 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 685727003413 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 685727003414 molybdopterin cofactor binding site; other site 685727003415 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 685727003416 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 685727003417 putative active site [active] 685727003418 catalytic residue [active] 685727003419 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 685727003420 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 685727003421 5S rRNA interface [nucleotide binding]; other site 685727003422 CTC domain interface [polypeptide binding]; other site 685727003423 L16 interface [polypeptide binding]; other site 685727003424 hypothetical protein; Validated; Region: PRK07121 685727003425 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 685727003426 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 685727003427 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 685727003428 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 685727003429 catalytic residue [active] 685727003430 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 685727003431 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 685727003432 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 685727003433 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 685727003434 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 685727003435 putative active site [active] 685727003436 putative dimer interface [polypeptide binding]; other site 685727003437 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 685727003438 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 685727003439 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 685727003440 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 685727003441 Coenzyme A binding pocket [chemical binding]; other site 685727003442 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 685727003443 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 685727003444 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 685727003445 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 685727003446 active site 685727003447 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 685727003448 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 685727003449 Substrate binding site; other site 685727003450 Mg++ binding site; other site 685727003451 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 685727003452 active site 685727003453 substrate binding site [chemical binding]; other site 685727003454 CoA binding site [chemical binding]; other site 685727003455 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727003456 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727003457 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 685727003458 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 685727003459 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 685727003460 ATP binding site [chemical binding]; other site 685727003461 putative Mg++ binding site [ion binding]; other site 685727003462 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 685727003463 nucleotide binding region [chemical binding]; other site 685727003464 ATP-binding site [chemical binding]; other site 685727003465 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 685727003466 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 685727003467 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 685727003468 homodimer interface [polypeptide binding]; other site 685727003469 metal binding site [ion binding]; metal-binding site 685727003470 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 685727003471 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685727003472 Walker A/P-loop; other site 685727003473 ATP binding site [chemical binding]; other site 685727003474 Q-loop/lid; other site 685727003475 ABC transporter signature motif; other site 685727003476 Walker B; other site 685727003477 D-loop; other site 685727003478 H-loop/switch region; other site 685727003479 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 685727003480 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 685727003481 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 685727003482 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 685727003483 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 685727003484 Imelysin; Region: Peptidase_M75; pfam09375 685727003485 Iron permease FTR1 family; Region: FTR1; cl00475 685727003486 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 685727003487 N-acetyl-D-glucosamine binding site [chemical binding]; other site 685727003488 enolase; Provisional; Region: eno; PRK00077 685727003489 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 685727003490 dimer interface [polypeptide binding]; other site 685727003491 metal binding site [ion binding]; metal-binding site 685727003492 substrate binding pocket [chemical binding]; other site 685727003493 Septum formation initiator; Region: DivIC; pfam04977 685727003494 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 685727003495 Uncharacterized conserved protein [Function unknown]; Region: COG1507 685727003496 exopolyphosphatase; Region: exo_poly_only; TIGR03706 685727003497 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 685727003498 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 685727003499 DNA-binding site [nucleotide binding]; DNA binding site 685727003500 RNA-binding motif; other site 685727003501 Predicted acetyltransferase [General function prediction only]; Region: COG2388 685727003502 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 685727003503 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 685727003504 active site 685727003505 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 685727003506 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 685727003507 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 685727003508 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 685727003509 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 685727003510 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 685727003511 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 685727003512 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685727003513 S-adenosylmethionine binding site [chemical binding]; other site 685727003514 Bax inhibitor 1 like; Region: BaxI_1; cl17691 685727003515 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 685727003516 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 685727003517 dimer interface [polypeptide binding]; other site 685727003518 active site 685727003519 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 685727003520 active site 685727003521 catalytic triad [active] 685727003522 oxyanion hole [active] 685727003523 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 685727003524 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 685727003525 dimer interface [polypeptide binding]; other site 685727003526 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685727003527 catalytic residue [active] 685727003528 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 685727003529 cystathionine gamma-synthase; Provisional; Region: PRK07811 685727003530 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 685727003531 homodimer interface [polypeptide binding]; other site 685727003532 substrate-cofactor binding pocket; other site 685727003533 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685727003534 catalytic residue [active] 685727003535 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 685727003536 N-acetyl-D-glucosamine binding site [chemical binding]; other site 685727003537 catalytic residue [active] 685727003538 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 685727003539 NlpC/P60 family; Region: NLPC_P60; pfam00877 685727003540 SEC-C motif; Region: SEC-C; pfam02810 685727003541 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 685727003542 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 685727003543 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 685727003544 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 685727003545 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 685727003546 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 685727003547 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 685727003548 catalytic residues [active] 685727003549 Putative esterase; Region: Esterase; pfam00756 685727003550 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 685727003551 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 685727003552 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 685727003553 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 685727003554 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 685727003555 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 685727003556 catalytic residue [active] 685727003557 putative FPP diphosphate binding site; other site 685727003558 putative FPP binding hydrophobic cleft; other site 685727003559 dimer interface [polypeptide binding]; other site 685727003560 putative IPP diphosphate binding site; other site 685727003561 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727003562 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727003563 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 685727003564 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 685727003565 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 685727003566 Beta-lactamase; Region: Beta-lactamase; pfam00144 685727003567 pantothenate kinase; Provisional; Region: PRK05439 685727003568 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 685727003569 ATP-binding site [chemical binding]; other site 685727003570 CoA-binding site [chemical binding]; other site 685727003571 Mg2+-binding site [ion binding]; other site 685727003572 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 685727003573 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 685727003574 dimer interface [polypeptide binding]; other site 685727003575 active site 685727003576 glycine-pyridoxal phosphate binding site [chemical binding]; other site 685727003577 folate binding site [chemical binding]; other site 685727003578 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 685727003579 active site 685727003580 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 685727003581 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 685727003582 putative active site [active] 685727003583 PhoH-like protein; Region: PhoH; pfam02562 685727003584 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 685727003585 Herpesvirus ICP4-like protein N-terminal region; Region: Herpes_ICP4_N; cl17480 685727003586 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 685727003587 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 685727003588 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 685727003589 fumarate hydratase; Reviewed; Region: fumC; PRK00485 685727003590 Class II fumarases; Region: Fumarase_classII; cd01362 685727003591 active site 685727003592 tetramer interface [polypeptide binding]; other site 685727003593 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 685727003594 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 685727003595 putative active site [active] 685727003596 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 685727003597 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 685727003598 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 685727003599 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 685727003600 generic binding surface II; other site 685727003601 generic binding surface I; other site 685727003602 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 685727003603 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 685727003604 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 685727003605 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 685727003606 active site 685727003607 metal binding site [ion binding]; metal-binding site 685727003608 DNA binding site [nucleotide binding] 685727003609 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685727003610 AAA domain; Region: AAA_23; pfam13476 685727003611 Walker A/P-loop; other site 685727003612 ATP binding site [chemical binding]; other site 685727003613 Q-loop/lid; other site 685727003614 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685727003615 Walker B; other site 685727003616 D-loop; other site 685727003617 H-loop/switch region; other site 685727003618 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 685727003619 Domain of unknown function DUF20; Region: UPF0118; pfam01594 685727003620 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 685727003621 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 685727003622 active site 685727003623 FMN binding site [chemical binding]; other site 685727003624 substrate binding site [chemical binding]; other site 685727003625 3Fe-4S cluster binding site [ion binding]; other site 685727003626 MarR family; Region: MarR_2; pfam12802 685727003627 MarR family; Region: MarR_2; cl17246 685727003628 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 685727003629 MarR family; Region: MarR; pfam01047 685727003630 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727003631 putative substrate translocation pore; other site 685727003632 Methyltransferase domain; Region: Methyltransf_31; pfam13847 685727003633 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685727003634 S-adenosylmethionine binding site [chemical binding]; other site 685727003635 Interferon-induced transmembrane protein; Region: CD225; pfam04505 685727003636 GTP-binding protein YchF; Reviewed; Region: PRK09601 685727003637 YchF GTPase; Region: YchF; cd01900 685727003638 G1 box; other site 685727003639 GTP/Mg2+ binding site [chemical binding]; other site 685727003640 Switch I region; other site 685727003641 G2 box; other site 685727003642 Switch II region; other site 685727003643 G3 box; other site 685727003644 G4 box; other site 685727003645 G5 box; other site 685727003646 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 685727003647 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 685727003648 active site 685727003649 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 685727003650 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 685727003651 4Fe-4S binding domain; Region: Fer4; pfam00037 685727003652 ferredoxin-NADP+ reductase; Region: PLN02852 685727003653 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 685727003654 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 685727003655 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 685727003656 substrate binding pocket [chemical binding]; other site 685727003657 membrane-bound complex binding site; other site 685727003658 hinge residues; other site 685727003659 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 685727003660 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685727003661 dimer interface [polypeptide binding]; other site 685727003662 conserved gate region; other site 685727003663 putative PBP binding loops; other site 685727003664 ABC-ATPase subunit interface; other site 685727003665 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 685727003666 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685727003667 Walker A/P-loop; other site 685727003668 ATP binding site [chemical binding]; other site 685727003669 Q-loop/lid; other site 685727003670 ABC transporter signature motif; other site 685727003671 Walker B; other site 685727003672 D-loop; other site 685727003673 H-loop/switch region; other site 685727003674 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 685727003675 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 685727003676 active site 685727003677 dimer interface [polypeptide binding]; other site 685727003678 non-prolyl cis peptide bond; other site 685727003679 insertion regions; other site 685727003680 Uncharacterized conserved protein [Function unknown]; Region: COG2128 685727003681 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 685727003682 hypothetical protein; Reviewed; Region: PRK09588 685727003683 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 685727003684 hydrophobic ligand binding site; other site 685727003685 short chain dehydrogenase; Provisional; Region: PRK05854 685727003686 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727003687 NAD(P) binding site [chemical binding]; other site 685727003688 active site 685727003689 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 685727003690 dimer interface [polypeptide binding]; other site 685727003691 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 685727003692 active site 685727003693 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 685727003694 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 685727003695 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 685727003696 catalytic residues [active] 685727003697 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 685727003698 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296 685727003699 putative NAD(P) binding site [chemical binding]; other site 685727003700 putative substrate binding site [chemical binding]; other site 685727003701 catalytic Zn binding site [ion binding]; other site 685727003702 structural Zn binding site [ion binding]; other site 685727003703 fumarate hydratase; Provisional; Region: PRK15389 685727003704 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 685727003705 Fumarase C-terminus; Region: Fumerase_C; pfam05683 685727003706 CAAX protease self-immunity; Region: Abi; pfam02517 685727003707 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727003708 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727003709 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 685727003710 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 685727003711 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 685727003712 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 685727003713 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 685727003714 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 685727003715 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727003716 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727003717 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 685727003718 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727003719 NAD(P) binding site [chemical binding]; other site 685727003720 active site 685727003721 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 685727003722 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 685727003723 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 685727003724 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 685727003725 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 685727003726 catalytic core [active] 685727003727 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 685727003728 putative CoA-transferase; Provisional; Region: PRK11430 685727003729 CoA-transferase family III; Region: CoA_transf_3; pfam02515 685727003730 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 685727003731 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 685727003732 PYR/PP interface [polypeptide binding]; other site 685727003733 dimer interface [polypeptide binding]; other site 685727003734 TPP binding site [chemical binding]; other site 685727003735 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 685727003736 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 685727003737 TPP-binding site; other site 685727003738 dimer interface [polypeptide binding]; other site 685727003739 hypothetical protein; Validated; Region: PRK07121 685727003740 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 685727003741 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 685727003742 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 685727003743 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 685727003744 short chain dehydrogenase; Provisional; Region: PRK07774 685727003745 classical (c) SDRs; Region: SDR_c; cd05233 685727003746 NAD(P) binding site [chemical binding]; other site 685727003747 active site 685727003748 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 685727003749 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 685727003750 NAD binding site [chemical binding]; other site 685727003751 catalytic residues [active] 685727003752 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 685727003753 classical (c) SDRs; Region: SDR_c; cd05233 685727003754 NAD(P) binding site [chemical binding]; other site 685727003755 active site 685727003756 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727003757 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727003758 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 685727003759 Cytochrome P450; Region: p450; cl12078 685727003760 short chain dehydrogenase; Provisional; Region: PRK07775 685727003761 classical (c) SDRs; Region: SDR_c; cd05233 685727003762 NAD(P) binding site [chemical binding]; other site 685727003763 active site 685727003764 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 685727003765 Cytochrome P450; Region: p450; cl12078 685727003766 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 685727003767 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 685727003768 acyl-CoA synthetase; Validated; Region: PRK07798 685727003769 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 685727003770 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 685727003771 acyl-activating enzyme (AAE) consensus motif; other site 685727003772 acyl-activating enzyme (AAE) consensus motif; other site 685727003773 putative AMP binding site [chemical binding]; other site 685727003774 putative active site [active] 685727003775 putative CoA binding site [chemical binding]; other site 685727003776 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 685727003777 active site 685727003778 putative catalytic site [active] 685727003779 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 685727003780 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 685727003781 active site 685727003782 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 685727003783 transcriptional regulator BetI; Validated; Region: PRK00767 685727003784 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727003785 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 685727003786 Predicted oxidoreductase [General function prediction only]; Region: COG3573 685727003787 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 685727003788 Mrr N-terminal domain; Region: Mrr_N; pfam14338 685727003789 Restriction endonuclease; Region: Mrr_cat; pfam04471 685727003790 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 685727003791 transcriptional regulator MalT; Provisional; Region: PRK04841 685727003792 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727003793 Major Facilitator Superfamily; Region: MFS_1; pfam07690 685727003794 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 685727003795 MarR family; Region: MarR_2; pfam12802 685727003796 mannosyltransferase; Provisional; Region: pimE; PRK13375 685727003797 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 685727003798 active site 685727003799 8-oxo-dGMP binding site [chemical binding]; other site 685727003800 nudix motif; other site 685727003801 metal binding site [ion binding]; metal-binding site 685727003802 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 685727003803 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 685727003804 G1 box; other site 685727003805 putative GEF interaction site [polypeptide binding]; other site 685727003806 GTP/Mg2+ binding site [chemical binding]; other site 685727003807 Switch I region; other site 685727003808 G2 box; other site 685727003809 G3 box; other site 685727003810 Switch II region; other site 685727003811 G4 box; other site 685727003812 G5 box; other site 685727003813 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 685727003814 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 685727003815 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 685727003816 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 685727003817 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 685727003818 Predicted membrane protein [Function unknown]; Region: COG3428 685727003819 Bacterial PH domain; Region: DUF304; pfam03703 685727003820 Uncharacterized conserved protein [Function unknown]; Region: COG3402 685727003821 FO synthase; Reviewed; Region: fbiC; PRK09234 685727003822 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 685727003823 FeS/SAM binding site; other site 685727003824 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 685727003825 FeS/SAM binding site; other site 685727003826 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 685727003827 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 685727003828 thiamine pyrophosphate protein; Provisional; Region: PRK08273 685727003829 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 685727003830 PYR/PP interface [polypeptide binding]; other site 685727003831 dimer interface [polypeptide binding]; other site 685727003832 tetramer interface [polypeptide binding]; other site 685727003833 TPP binding site [chemical binding]; other site 685727003834 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 685727003835 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 685727003836 TPP-binding site [chemical binding]; other site 685727003837 Ferredoxin [Energy production and conversion]; Region: COG1146 685727003838 4Fe-4S binding domain; Region: Fer4; pfam00037 685727003839 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 685727003840 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 685727003841 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685727003842 homodimer interface [polypeptide binding]; other site 685727003843 catalytic residue [active] 685727003844 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 685727003845 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 685727003846 NAD(P) binding site [chemical binding]; other site 685727003847 catalytic residues [active] 685727003848 Proline dehydrogenase; Region: Pro_dh; cl03282 685727003849 acyl-CoA synthetase; Validated; Region: PRK07787 685727003850 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 685727003851 acyl-activating enzyme (AAE) consensus motif; other site 685727003852 AMP binding site [chemical binding]; other site 685727003853 active site 685727003854 CoA binding site [chemical binding]; other site 685727003855 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293 685727003856 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 685727003857 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 685727003858 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 685727003859 Prostaglandin dehydrogenases; Region: PGDH; cd05288 685727003860 NAD(P) binding site [chemical binding]; other site 685727003861 substrate binding site [chemical binding]; other site 685727003862 dimer interface [polypeptide binding]; other site 685727003863 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 685727003864 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 685727003865 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727003866 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727003867 Domain of unknown function (DUF4304); Region: DUF4304; pfam14137 685727003868 enoyl-CoA hydratase; Provisional; Region: PRK05864 685727003869 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 685727003870 substrate binding site [chemical binding]; other site 685727003871 oxyanion hole (OAH) forming residues; other site 685727003872 trimer interface [polypeptide binding]; other site 685727003873 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 685727003874 Spore germination protein; Region: Spore_permease; cl17796 685727003875 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 685727003876 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 685727003877 putative trimer interface [polypeptide binding]; other site 685727003878 putative CoA binding site [chemical binding]; other site 685727003879 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 685727003880 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 685727003881 metal binding site [ion binding]; metal-binding site 685727003882 putative dimer interface [polypeptide binding]; other site 685727003883 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 685727003884 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 685727003885 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 685727003886 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 685727003887 acyl-activating enzyme (AAE) consensus motif; other site 685727003888 putative AMP binding site [chemical binding]; other site 685727003889 putative active site [active] 685727003890 putative CoA binding site [chemical binding]; other site 685727003891 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 685727003892 dihydropteroate synthase; Region: DHPS; TIGR01496 685727003893 substrate binding pocket [chemical binding]; other site 685727003894 dimer interface [polypeptide binding]; other site 685727003895 inhibitor binding site; inhibition site 685727003896 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 685727003897 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 685727003898 DivIVA domain; Region: DivI1A_domain; TIGR03544 685727003899 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 685727003900 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 685727003901 Methyltransferase domain; Region: Methyltransf_26; pfam13659 685727003902 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 685727003903 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 685727003904 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 685727003905 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 685727003906 ligand binding site; other site 685727003907 oligomer interface; other site 685727003908 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 685727003909 dimer interface [polypeptide binding]; other site 685727003910 N-terminal domain interface [polypeptide binding]; other site 685727003911 sulfate 1 binding site; other site 685727003912 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 685727003913 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685727003914 S-adenosylmethionine binding site [chemical binding]; other site 685727003915 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 685727003916 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 685727003917 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 685727003918 DNA binding residues [nucleotide binding] 685727003919 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 685727003920 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 685727003921 sec-independent translocase; Provisional; Region: PRK03100 685727003922 Domain of unknown function DUF59; Region: DUF59; cl00941 685727003923 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 685727003924 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 685727003925 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 685727003926 N-acetyl-D-glucosamine binding site [chemical binding]; other site 685727003927 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 685727003928 PRC-barrel domain; Region: PRC; pfam05239 685727003929 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 685727003930 MgtE intracellular N domain; Region: MgtE_N; smart00924 685727003931 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 685727003932 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 685727003933 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727003934 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 685727003935 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 685727003936 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 685727003937 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 685727003938 active site 685727003939 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 685727003940 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 685727003941 Malic enzyme, N-terminal domain; Region: malic; pfam00390 685727003942 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 685727003943 NAD(P) binding pocket [chemical binding]; other site 685727003944 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 685727003945 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685727003946 ABC-ATPase subunit interface; other site 685727003947 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 685727003948 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 685727003949 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 685727003950 Walker A/P-loop; other site 685727003951 ATP binding site [chemical binding]; other site 685727003952 Q-loop/lid; other site 685727003953 ABC transporter signature motif; other site 685727003954 Walker B; other site 685727003955 D-loop; other site 685727003956 H-loop/switch region; other site 685727003957 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 685727003958 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 685727003959 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 685727003960 short chain dehydrogenase; Provisional; Region: PRK07832 685727003961 classical (c) SDRs; Region: SDR_c; cd05233 685727003962 NAD(P) binding site [chemical binding]; other site 685727003963 active site 685727003964 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 685727003965 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 685727003966 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727003967 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727003968 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 685727003969 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 685727003970 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 685727003971 TPP-binding site [chemical binding]; other site 685727003972 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 685727003973 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 685727003974 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 685727003975 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685727003976 Walker A/P-loop; other site 685727003977 ATP binding site [chemical binding]; other site 685727003978 Q-loop/lid; other site 685727003979 ABC transporter signature motif; other site 685727003980 Walker B; other site 685727003981 D-loop; other site 685727003982 H-loop/switch region; other site 685727003983 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 685727003984 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 685727003985 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685727003986 Walker A/P-loop; other site 685727003987 ATP binding site [chemical binding]; other site 685727003988 Q-loop/lid; other site 685727003989 ABC transporter signature motif; other site 685727003990 Walker B; other site 685727003991 D-loop; other site 685727003992 H-loop/switch region; other site 685727003993 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 685727003994 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 685727003995 Walker A/P-loop; other site 685727003996 ATP binding site [chemical binding]; other site 685727003997 Q-loop/lid; other site 685727003998 ABC transporter signature motif; other site 685727003999 Walker B; other site 685727004000 D-loop; other site 685727004001 H-loop/switch region; other site 685727004002 Domain of unknown function (DUF305); Region: DUF305; pfam03713 685727004003 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 685727004004 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 685727004005 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 685727004006 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 685727004007 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 685727004008 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 685727004009 putative dimer interface [polypeptide binding]; other site 685727004010 N-terminal domain interface [polypeptide binding]; other site 685727004011 putative substrate binding pocket (H-site) [chemical binding]; other site 685727004012 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 685727004013 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 685727004014 AAA ATPase domain; Region: AAA_16; pfam13191 685727004015 Predicted ATPase [General function prediction only]; Region: COG3903 685727004016 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 685727004017 TPR motif; other site 685727004018 binding surface 685727004019 Tetratricopeptide repeat; Region: TPR_12; pfam13424 685727004020 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 685727004021 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 685727004022 DNA binding residues [nucleotide binding] 685727004023 dimerization interface [polypeptide binding]; other site 685727004024 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 685727004025 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 685727004026 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 685727004027 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 685727004028 substrate binding site [chemical binding]; other site 685727004029 oxyanion hole (OAH) forming residues; other site 685727004030 trimer interface [polypeptide binding]; other site 685727004031 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 685727004032 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 685727004033 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 685727004034 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 685727004035 acyl-activating enzyme (AAE) consensus motif; other site 685727004036 acyl-activating enzyme (AAE) consensus motif; other site 685727004037 AMP binding site [chemical binding]; other site 685727004038 active site 685727004039 CoA binding site [chemical binding]; other site 685727004040 enoyl-CoA hydratase; Provisional; Region: PRK08252 685727004041 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 685727004042 substrate binding site [chemical binding]; other site 685727004043 oxyanion hole (OAH) forming residues; other site 685727004044 trimer interface [polypeptide binding]; other site 685727004045 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 685727004046 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 685727004047 active site 685727004048 purine riboside binding site [chemical binding]; other site 685727004049 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 685727004050 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 685727004051 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 685727004052 dimerization interface [polypeptide binding]; other site 685727004053 DPS ferroxidase diiron center [ion binding]; other site 685727004054 ion pore; other site 685727004055 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 685727004056 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 685727004057 dimer interface [polypeptide binding]; other site 685727004058 active site 685727004059 Amidase; Region: Amidase; cl11426 685727004060 indole-3-acetamide amidohydrolase; Region: PLN02722 685727004061 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 685727004062 FAD binding domain; Region: FAD_binding_4; pfam01565 685727004063 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 685727004064 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727004065 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 685727004066 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 685727004067 active site 685727004068 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 685727004069 dimer interface [polypeptide binding]; other site 685727004070 substrate binding site [chemical binding]; other site 685727004071 catalytic residue [active] 685727004072 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 685727004073 RNase_H superfamily; Region: RNase_H_2; pfam13482 685727004074 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 685727004075 AAA domain; Region: AAA_12; pfam13087 685727004076 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 685727004077 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 685727004078 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 685727004079 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 685727004080 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 685727004081 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 685727004082 acyl-activating enzyme (AAE) consensus motif; other site 685727004083 putative AMP binding site [chemical binding]; other site 685727004084 putative active site [active] 685727004085 putative CoA binding site [chemical binding]; other site 685727004086 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 685727004087 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 685727004088 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 685727004089 putative active site [active] 685727004090 putative substrate binding site [chemical binding]; other site 685727004091 putative FMN binding site [chemical binding]; other site 685727004092 putative catalytic residues [active] 685727004093 tryptophan synthase subunit beta; Reviewed; Region: PRK12391 685727004094 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 685727004095 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 685727004096 catalytic residue [active] 685727004097 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 685727004098 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 685727004099 ATP binding site [chemical binding]; other site 685727004100 Mg++ binding site [ion binding]; other site 685727004101 motif III; other site 685727004102 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 685727004103 nucleotide binding region [chemical binding]; other site 685727004104 ATP-binding site [chemical binding]; other site 685727004105 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 685727004106 putative RNA binding site [nucleotide binding]; other site 685727004107 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 685727004108 NlpC/P60 family; Region: NLPC_P60; pfam00877 685727004109 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 685727004110 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685727004111 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 685727004112 Walker A/P-loop; other site 685727004113 ATP binding site [chemical binding]; other site 685727004114 Q-loop/lid; other site 685727004115 ABC transporter signature motif; other site 685727004116 Walker B; other site 685727004117 D-loop; other site 685727004118 H-loop/switch region; other site 685727004119 endonuclease IV; Provisional; Region: PRK01060 685727004120 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 685727004121 AP (apurinic/apyrimidinic) site pocket; other site 685727004122 DNA interaction; other site 685727004123 Metal-binding active site; metal-binding site 685727004124 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 685727004125 classical (c) SDRs; Region: SDR_c; cd05233 685727004126 NAD(P) binding site [chemical binding]; other site 685727004127 active site 685727004128 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 685727004129 Sulfatase; Region: Sulfatase; pfam00884 685727004130 Laminin G domain; Region: Laminin_G_2; pfam02210 685727004131 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 685727004132 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 685727004133 Walker A/P-loop; other site 685727004134 ATP binding site [chemical binding]; other site 685727004135 Q-loop/lid; other site 685727004136 ABC transporter signature motif; other site 685727004137 Walker B; other site 685727004138 D-loop; other site 685727004139 H-loop/switch region; other site 685727004140 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 685727004141 FtsX-like permease family; Region: FtsX; pfam02687 685727004142 FtsX-like permease family; Region: FtsX; pfam02687 685727004143 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 685727004144 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 685727004145 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 685727004146 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 685727004147 FAD binding pocket [chemical binding]; other site 685727004148 FAD binding motif [chemical binding]; other site 685727004149 phosphate binding motif [ion binding]; other site 685727004150 beta-alpha-beta structure motif; other site 685727004151 NAD binding pocket [chemical binding]; other site 685727004152 Iron coordination center [ion binding]; other site 685727004153 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 685727004154 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 685727004155 ligand binding site [chemical binding]; other site 685727004156 flexible hinge region; other site 685727004157 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 685727004158 4Fe-4S dicluster domain; Region: Fer4_18; pfam13746 685727004159 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 685727004160 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 685727004161 putative substrate binding site [chemical binding]; other site 685727004162 putative ATP binding site [chemical binding]; other site 685727004163 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 685727004164 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 685727004165 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 685727004166 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685727004167 motif II; other site 685727004168 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 685727004169 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 685727004170 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685727004171 active site 685727004172 phosphorylation site [posttranslational modification] 685727004173 intermolecular recognition site; other site 685727004174 dimerization interface [polypeptide binding]; other site 685727004175 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 685727004176 dimerization interface [polypeptide binding]; other site 685727004177 DNA binding residues [nucleotide binding] 685727004178 phosphoenolpyruvate synthase; Validated; Region: PRK06464 685727004179 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 685727004180 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 685727004181 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 685727004182 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 685727004183 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 685727004184 putative dimer interface [polypeptide binding]; other site 685727004185 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 685727004186 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 685727004187 active site 685727004188 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 685727004189 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 685727004190 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 685727004191 active site 685727004192 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 685727004193 Predicted ATPase [General function prediction only]; Region: COG3903 685727004194 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 685727004195 TPR motif; other site 685727004196 binding surface 685727004197 Domain of unknown function (DUF222); Region: DUF222; pfam02720 685727004198 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 685727004199 active site 685727004200 Part of AAA domain; Region: AAA_19; pfam13245 685727004201 Family description; Region: UvrD_C_2; pfam13538 685727004202 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 685727004203 active site 685727004204 catalytic residues [active] 685727004205 metal binding site [ion binding]; metal-binding site 685727004206 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 685727004207 CoA-transferase family III; Region: CoA_transf_3; pfam02515 685727004208 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727004209 short chain dehydrogenase; Provisional; Region: PRK08303 685727004210 NAD(P) binding site [chemical binding]; other site 685727004211 active site 685727004212 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 685727004213 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 685727004214 active site 685727004215 multimer interface [polypeptide binding]; other site 685727004216 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727004217 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727004218 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 685727004219 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 685727004220 inhibitor-cofactor binding pocket; inhibition site 685727004221 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685727004222 catalytic residue [active] 685727004223 Amidohydrolase; Region: Amidohydro_2; pfam04909 685727004224 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 685727004225 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727004226 NAD(P) binding site [chemical binding]; other site 685727004227 active site 685727004228 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 685727004229 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 685727004230 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 685727004231 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 685727004232 active site 685727004233 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 685727004234 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 685727004235 active site 685727004236 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727004237 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 685727004238 NAD(P) binding site [chemical binding]; other site 685727004239 active site 685727004240 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727004241 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727004242 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 685727004243 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 685727004244 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 685727004245 hydrophobic ligand binding site; other site 685727004246 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 685727004247 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 685727004248 Transcriptional regulator [Transcription]; Region: IclR; COG1414 685727004249 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 685727004250 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 685727004251 active site 685727004252 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727004253 NAD(P) binding site [chemical binding]; other site 685727004254 active site 685727004255 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727004256 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727004257 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 685727004258 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 685727004259 substrate binding site [chemical binding]; other site 685727004260 oxyanion hole (OAH) forming residues; other site 685727004261 trimer interface [polypeptide binding]; other site 685727004262 CoA-transferase family III; Region: CoA_transf_3; pfam02515 685727004263 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 685727004264 active site 685727004265 AMP-binding enzyme; Region: AMP-binding; pfam00501 685727004266 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 685727004267 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 685727004268 acyl-activating enzyme (AAE) consensus motif; other site 685727004269 acyl-activating enzyme (AAE) consensus motif; other site 685727004270 putative AMP binding site [chemical binding]; other site 685727004271 putative active site [active] 685727004272 putative CoA binding site [chemical binding]; other site 685727004273 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 685727004274 CoA-transferase family III; Region: CoA_transf_3; pfam02515 685727004275 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 685727004276 CoA-transferase family III; Region: CoA_transf_3; pfam02515 685727004277 lipid-transfer protein; Provisional; Region: PRK07855 685727004278 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 685727004279 active site 685727004280 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 685727004281 DUF35 OB-fold domain; Region: DUF35; pfam01796 685727004282 short chain dehydrogenase; Provisional; Region: PRK06172 685727004283 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727004284 NAD(P) binding site [chemical binding]; other site 685727004285 active site 685727004286 Amidohydrolase; Region: Amidohydro_2; pfam04909 685727004287 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 685727004288 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 685727004289 NAD(P) binding site [chemical binding]; other site 685727004290 Excalibur calcium-binding domain; Region: Excalibur; smart00894 685727004291 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 685727004292 Putative esterase; Region: Esterase; pfam00756 685727004293 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 685727004294 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 685727004295 allophanate hydrolase; Provisional; Region: PRK08186 685727004296 Amidase; Region: Amidase; cl11426 685727004297 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 685727004298 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 685727004299 NMT1-like family; Region: NMT1_2; pfam13379 685727004300 substrate binding pocket [chemical binding]; other site 685727004301 membrane-bound complex binding site; other site 685727004302 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 685727004303 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685727004304 dimer interface [polypeptide binding]; other site 685727004305 conserved gate region; other site 685727004306 putative PBP binding loops; other site 685727004307 ABC-ATPase subunit interface; other site 685727004308 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 685727004309 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 685727004310 Walker A/P-loop; other site 685727004311 ATP binding site [chemical binding]; other site 685727004312 Q-loop/lid; other site 685727004313 ABC transporter signature motif; other site 685727004314 Walker B; other site 685727004315 D-loop; other site 685727004316 H-loop/switch region; other site 685727004317 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 685727004318 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 685727004319 DNA-binding site [nucleotide binding]; DNA binding site 685727004320 FCD domain; Region: FCD; pfam07729 685727004321 Transcriptional regulators [Transcription]; Region: MarR; COG1846 685727004322 MarR family; Region: MarR_2; pfam12802 685727004323 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 685727004324 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 685727004325 acyl-activating enzyme (AAE) consensus motif; other site 685727004326 putative AMP binding site [chemical binding]; other site 685727004327 putative active site [active] 685727004328 putative CoA binding site [chemical binding]; other site 685727004329 NAD-dependent deacetylase; Provisional; Region: PRK00481 685727004330 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 685727004331 NAD+ binding site [chemical binding]; other site 685727004332 substrate binding site [chemical binding]; other site 685727004333 Zn binding site [ion binding]; other site 685727004334 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 685727004335 Fe-S cluster binding site [ion binding]; other site 685727004336 DNA binding site [nucleotide binding] 685727004337 active site 685727004338 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 685727004339 active site 685727004340 metal binding site [ion binding]; metal-binding site 685727004341 3-ketosteroid-delta-1-dehydrogenase; Provisional; Region: PRK12837 685727004342 L-aspartate oxidase; Provisional; Region: PRK06175 685727004343 Predicted oxidoreductase [General function prediction only]; Region: COG3573 685727004344 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 685727004345 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 685727004346 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 685727004347 Walker A/P-loop; other site 685727004348 ATP binding site [chemical binding]; other site 685727004349 Q-loop/lid; other site 685727004350 ABC transporter signature motif; other site 685727004351 Walker B; other site 685727004352 D-loop; other site 685727004353 H-loop/switch region; other site 685727004354 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 685727004355 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685727004356 dimer interface [polypeptide binding]; other site 685727004357 conserved gate region; other site 685727004358 putative PBP binding loops; other site 685727004359 ABC-ATPase subunit interface; other site 685727004360 NMT1/THI5 like; Region: NMT1; pfam09084 685727004361 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 685727004362 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 685727004363 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 685727004364 substrate binding pocket [chemical binding]; other site 685727004365 catalytic triad [active] 685727004366 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 685727004367 FMN binding site [chemical binding]; other site 685727004368 dimer interface [polypeptide binding]; other site 685727004369 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 685727004370 potential frameshift: common BLAST hit: gi|226307493|ref|YP_002767453.1| drug resistance efflux protein 685727004371 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727004372 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727004373 putative substrate translocation pore; other site 685727004374 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 685727004375 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 685727004376 FtsX-like permease family; Region: FtsX; pfam02687 685727004377 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 685727004378 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 685727004379 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 685727004380 Walker A/P-loop; other site 685727004381 ATP binding site [chemical binding]; other site 685727004382 Q-loop/lid; other site 685727004383 ABC transporter signature motif; other site 685727004384 Walker B; other site 685727004385 D-loop; other site 685727004386 H-loop/switch region; other site 685727004387 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 685727004388 putative DNA binding site [nucleotide binding]; other site 685727004389 WYL domain; Region: WYL; pfam13280 685727004390 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 685727004391 dimer interface [polypeptide binding]; other site 685727004392 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 685727004393 Putative sensor; Region: Sensor; pfam13796 685727004394 Histidine kinase; Region: HisKA_3; pfam07730 685727004395 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 685727004396 ATP binding site [chemical binding]; other site 685727004397 Mg2+ binding site [ion binding]; other site 685727004398 G-X-G motif; other site 685727004399 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 685727004400 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685727004401 phosphorylation site [posttranslational modification] 685727004402 intermolecular recognition site; other site 685727004403 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 685727004404 DNA binding residues [nucleotide binding] 685727004405 dimerization interface [polypeptide binding]; other site 685727004406 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 685727004407 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 685727004408 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 685727004409 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 685727004410 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 685727004411 substrate binding pocket [chemical binding]; other site 685727004412 membrane-bound complex binding site; other site 685727004413 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 685727004414 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685727004415 dimer interface [polypeptide binding]; other site 685727004416 conserved gate region; other site 685727004417 putative PBP binding loops; other site 685727004418 ABC-ATPase subunit interface; other site 685727004419 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 685727004420 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685727004421 Walker A/P-loop; other site 685727004422 ATP binding site [chemical binding]; other site 685727004423 Q-loop/lid; other site 685727004424 ABC transporter signature motif; other site 685727004425 Walker B; other site 685727004426 D-loop; other site 685727004427 H-loop/switch region; other site 685727004428 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 685727004429 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 685727004430 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 685727004431 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 685727004432 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 685727004433 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 685727004434 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 685727004435 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 685727004436 substrate binding pocket [chemical binding]; other site 685727004437 membrane-bound complex binding site; other site 685727004438 hinge residues; other site 685727004439 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685727004440 S-adenosylmethionine binding site [chemical binding]; other site 685727004441 Domain of unknown function (DUF222); Region: DUF222; pfam02720 685727004442 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 685727004443 active site 685727004444 SdpI/YhfL protein family; Region: SdpI; pfam13630 685727004445 enoyl-CoA hydratase; Provisional; Region: PRK06688 685727004446 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 685727004447 substrate binding site [chemical binding]; other site 685727004448 oxyanion hole (OAH) forming residues; other site 685727004449 trimer interface [polypeptide binding]; other site 685727004450 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 685727004451 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 685727004452 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 685727004453 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 685727004454 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 685727004455 Coenzyme A binding pocket [chemical binding]; other site 685727004456 Short C-terminal domain; Region: SHOCT; pfam09851 685727004457 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 685727004458 Short C-terminal domain; Region: SHOCT; pfam09851 685727004459 CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with...; Region: CIDE_N; cl02541 685727004460 putative heterodimer interaction sites [polypeptide binding]; other site 685727004461 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 685727004462 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 685727004463 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 685727004464 RNase III inhibitor; Provisional; Region: PRK00431 685727004465 ADP-ribose binding site [chemical binding]; other site 685727004466 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 685727004467 DNA-binding site [nucleotide binding]; DNA binding site 685727004468 Transcriptional regulators [Transcription]; Region: FadR; COG2186 685727004469 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 685727004470 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 685727004471 L-lactate permease; Region: Lactate_perm; cl00701 685727004472 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 685727004473 Cysteine-rich domain; Region: CCG; pfam02754 685727004474 Cysteine-rich domain; Region: CCG; pfam02754 685727004475 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 685727004476 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 685727004477 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 685727004478 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 685727004479 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 685727004480 putative dimer interface [polypeptide binding]; other site 685727004481 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 685727004482 Helix-turn-helix domain; Region: HTH_18; pfam12833 685727004483 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 685727004484 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 685727004485 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 685727004486 Part of AAA domain; Region: AAA_19; pfam13245 685727004487 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 685727004488 Family description; Region: UvrD_C_2; pfam13538 685727004489 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 685727004490 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 685727004491 AAA domain; Region: AAA_30; pfam13604 685727004492 Family description; Region: UvrD_C_2; pfam13538 685727004493 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 685727004494 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 685727004495 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 685727004496 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 685727004497 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 685727004498 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 685727004499 Part of AAA domain; Region: AAA_19; pfam13245 685727004500 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 685727004501 AAA domain; Region: AAA_12; pfam13087 685727004502 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 685727004503 putative active site [active] 685727004504 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 685727004505 Hexokinase; Region: Hexokinase_2; pfam03727 685727004506 Family description; Region: UvrD_C_2; pfam13538 685727004507 Uncharacterized conserved protein [Function unknown]; Region: COG1479 685727004508 Protein of unknown function DUF262; Region: DUF262; pfam03235 685727004509 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 685727004510 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 685727004511 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 685727004512 ATP binding site [chemical binding]; other site 685727004513 putative Mg++ binding site [ion binding]; other site 685727004514 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 685727004515 ATP-binding site [chemical binding]; other site 685727004516 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 685727004517 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 685727004518 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 685727004519 ATP binding site [chemical binding]; other site 685727004520 putative Mg++ binding site [ion binding]; other site 685727004521 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 685727004522 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 685727004523 nucleotide binding region [chemical binding]; other site 685727004524 ATP-binding site [chemical binding]; other site 685727004525 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 685727004526 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 685727004527 ATP binding site [chemical binding]; other site 685727004528 putative Mg++ binding site [ion binding]; other site 685727004529 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 685727004530 ATP-binding site [chemical binding]; other site 685727004531 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 685727004532 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 685727004533 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 685727004534 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 685727004535 active site 685727004536 nucleotide binding site [chemical binding]; other site 685727004537 HIGH motif; other site 685727004538 KMSKS motif; other site 685727004539 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 685727004540 FAD binding domain; Region: FAD_binding_4; pfam01565 685727004541 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 685727004542 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 685727004543 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 685727004544 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 685727004545 PPE family; Region: PPE; pfam00823 685727004546 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 685727004547 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685727004548 motif II; other site 685727004549 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 685727004550 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 685727004551 putative acyl-acceptor binding pocket; other site 685727004552 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 685727004553 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 685727004554 putative acyl-acceptor binding pocket; other site 685727004555 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 685727004556 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 685727004557 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 685727004558 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129 685727004559 catalytic triad [active] 685727004560 active site nucleophile [active] 685727004561 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 685727004562 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 685727004563 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 685727004564 AMP-binding enzyme; Region: AMP-binding; pfam00501 685727004565 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 685727004566 acyl-activating enzyme (AAE) consensus motif; other site 685727004567 putative AMP binding site [chemical binding]; other site 685727004568 putative active site [active] 685727004569 putative CoA binding site [chemical binding]; other site 685727004570 Protein of unknown function, DUF488; Region: DUF488; cl01246 685727004571 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 685727004572 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 685727004573 ligand binding site [chemical binding]; other site 685727004574 homodimer interface [polypeptide binding]; other site 685727004575 NAD(P) binding site [chemical binding]; other site 685727004576 trimer interface B [polypeptide binding]; other site 685727004577 trimer interface A [polypeptide binding]; other site 685727004578 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 685727004579 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 685727004580 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 685727004581 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727004582 Major Facilitator Superfamily; Region: MFS_1; pfam07690 685727004583 putative substrate translocation pore; other site 685727004584 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 685727004585 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 685727004586 E3 interaction surface; other site 685727004587 lipoyl attachment site [posttranslational modification]; other site 685727004588 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 685727004589 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 685727004590 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 685727004591 alpha subunit interface [polypeptide binding]; other site 685727004592 TPP binding site [chemical binding]; other site 685727004593 heterodimer interface [polypeptide binding]; other site 685727004594 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 685727004595 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 685727004596 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 685727004597 TPP-binding site [chemical binding]; other site 685727004598 heterodimer interface [polypeptide binding]; other site 685727004599 tetramer interface [polypeptide binding]; other site 685727004600 phosphorylation loop region [posttranslational modification] 685727004601 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 685727004602 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 685727004603 AsnC family; Region: AsnC_trans_reg; pfam01037 685727004604 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 685727004605 putative active site [active] 685727004606 putative substrate binding site [chemical binding]; other site 685727004607 ATP binding site [chemical binding]; other site 685727004608 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 685727004609 active site 685727004610 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 685727004611 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 685727004612 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 685727004613 shikimate binding site; other site 685727004614 NAD(P) binding site [chemical binding]; other site 685727004615 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 685727004616 SNF2 Helicase protein; Region: DUF3670; pfam12419 685727004617 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 685727004618 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 685727004619 ATP binding site [chemical binding]; other site 685727004620 putative Mg++ binding site [ion binding]; other site 685727004621 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 685727004622 nucleotide binding region [chemical binding]; other site 685727004623 ATP-binding site [chemical binding]; other site 685727004624 Uncharacterized conserved protein [Function unknown]; Region: COG4279 685727004625 SWIM zinc finger; Region: SWIM; pfam04434 685727004626 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 685727004627 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 685727004628 metal binding site [ion binding]; metal-binding site 685727004629 putative dimer interface [polypeptide binding]; other site 685727004630 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 685727004631 hydrophobic ligand binding site; other site 685727004632 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 685727004633 SnoaL-like domain; Region: SnoaL_2; pfam12680 685727004634 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 685727004635 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 685727004636 non-specific DNA binding site [nucleotide binding]; other site 685727004637 salt bridge; other site 685727004638 sequence-specific DNA binding site [nucleotide binding]; other site 685727004639 TAP-like protein; Region: Abhydrolase_4; pfam08386 685727004640 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 685727004641 Sulfatase; Region: Sulfatase; pfam00884 685727004642 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 685727004643 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 685727004644 tetrameric interface [polypeptide binding]; other site 685727004645 NAD binding site [chemical binding]; other site 685727004646 catalytic residues [active] 685727004647 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 685727004648 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 685727004649 active site 685727004650 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 685727004651 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 685727004652 active site 685727004653 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 685727004654 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 685727004655 substrate binding site [chemical binding]; other site 685727004656 oxyanion hole (OAH) forming residues; other site 685727004657 trimer interface [polypeptide binding]; other site 685727004658 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 685727004659 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 685727004660 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 685727004661 enoyl-CoA hydratase; Provisional; Region: PRK05862 685727004662 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 685727004663 substrate binding site [chemical binding]; other site 685727004664 oxyanion hole (OAH) forming residues; other site 685727004665 trimer interface [polypeptide binding]; other site 685727004666 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 685727004667 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 685727004668 MarR family; Region: MarR_2; pfam12802 685727004669 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 685727004670 MarR family; Region: MarR; pfam01047 685727004671 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727004672 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 685727004673 putative substrate translocation pore; other site 685727004674 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727004675 putative substrate translocation pore; other site 685727004676 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 685727004677 short chain dehydrogenase; Provisional; Region: PRK07890 685727004678 classical (c) SDRs; Region: SDR_c; cd05233 685727004679 NAD(P) binding site [chemical binding]; other site 685727004680 active site 685727004681 Transcriptional regulator [Transcription]; Region: IclR; COG1414 685727004682 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 685727004683 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 685727004684 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 685727004685 Active Sites [active] 685727004686 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 685727004687 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 685727004688 CysD dimerization site [polypeptide binding]; other site 685727004689 G1 box; other site 685727004690 putative GEF interaction site [polypeptide binding]; other site 685727004691 GTP/Mg2+ binding site [chemical binding]; other site 685727004692 Switch I region; other site 685727004693 G2 box; other site 685727004694 G3 box; other site 685727004695 Switch II region; other site 685727004696 G4 box; other site 685727004697 G5 box; other site 685727004698 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 685727004699 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 685727004700 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 685727004701 ligand-binding site [chemical binding]; other site 685727004702 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 685727004703 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 685727004704 active site 685727004705 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_7; cd08900 685727004706 putative hydrophobic ligand binding site [chemical binding]; other site 685727004707 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 685727004708 dimerization interface [polypeptide binding]; other site 685727004709 putative DNA binding site [nucleotide binding]; other site 685727004710 putative Zn2+ binding site [ion binding]; other site 685727004711 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 685727004712 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 685727004713 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 685727004714 Domain of unknown function (DUF305); Region: DUF305; pfam03713 685727004715 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 685727004716 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 685727004717 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 685727004718 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 685727004719 active site 685727004720 HIGH motif; other site 685727004721 KMSK motif region; other site 685727004722 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 685727004723 tRNA binding surface [nucleotide binding]; other site 685727004724 anticodon binding site; other site 685727004725 diaminopimelate decarboxylase; Region: lysA; TIGR01048 685727004726 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 685727004727 active site 685727004728 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 685727004729 substrate binding site [chemical binding]; other site 685727004730 catalytic residues [active] 685727004731 dimer interface [polypeptide binding]; other site 685727004732 homoserine dehydrogenase; Provisional; Region: PRK06349 685727004733 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 685727004734 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 685727004735 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 685727004736 threonine synthase; Reviewed; Region: PRK06721 685727004737 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 685727004738 homodimer interface [polypeptide binding]; other site 685727004739 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685727004740 catalytic residue [active] 685727004741 homoserine kinase; Provisional; Region: PRK01212 685727004742 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 685727004743 transcription termination factor Rho; Provisional; Region: PRK12608 685727004744 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 685727004745 RNA binding site [nucleotide binding]; other site 685727004746 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 685727004747 multimer interface [polypeptide binding]; other site 685727004748 Walker A motif; other site 685727004749 ATP binding site [chemical binding]; other site 685727004750 Walker B motif; other site 685727004751 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 685727004752 peptide chain release factor 1; Validated; Region: prfA; PRK00591 685727004753 This domain is found in peptide chain release factors; Region: PCRF; smart00937 685727004754 RF-1 domain; Region: RF-1; pfam00472 685727004755 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 685727004756 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685727004757 S-adenosylmethionine binding site [chemical binding]; other site 685727004758 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 685727004759 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 685727004760 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 685727004761 Mg++ binding site [ion binding]; other site 685727004762 putative catalytic motif [active] 685727004763 substrate binding site [chemical binding]; other site 685727004764 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 685727004765 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 685727004766 ATP synthase subunit C; Region: ATP-synt_C; cl00466 685727004767 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 685727004768 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 685727004769 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 685727004770 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 685727004771 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 685727004772 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 685727004773 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 685727004774 beta subunit interaction interface [polypeptide binding]; other site 685727004775 Walker A motif; other site 685727004776 ATP binding site [chemical binding]; other site 685727004777 Walker B motif; other site 685727004778 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 685727004779 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 685727004780 core domain interface [polypeptide binding]; other site 685727004781 delta subunit interface [polypeptide binding]; other site 685727004782 epsilon subunit interface [polypeptide binding]; other site 685727004783 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 685727004784 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 685727004785 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 685727004786 alpha subunit interaction interface [polypeptide binding]; other site 685727004787 Walker A motif; other site 685727004788 ATP binding site [chemical binding]; other site 685727004789 Walker B motif; other site 685727004790 inhibitor binding site; inhibition site 685727004791 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 685727004792 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 685727004793 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 685727004794 gamma subunit interface [polypeptide binding]; other site 685727004795 epsilon subunit interface [polypeptide binding]; other site 685727004796 LBP interface [polypeptide binding]; other site 685727004797 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 685727004798 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 685727004799 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 685727004800 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 685727004801 hinge; other site 685727004802 active site 685727004803 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 685727004804 dimerization interface [polypeptide binding]; other site 685727004805 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 685727004806 cyclase homology domain; Region: CHD; cd07302 685727004807 nucleotidyl binding site; other site 685727004808 metal binding site [ion binding]; metal-binding site 685727004809 dimer interface [polypeptide binding]; other site 685727004810 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 685727004811 hypothetical protein; Provisional; Region: PRK03298 685727004812 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 685727004813 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 685727004814 dimer interface [polypeptide binding]; other site 685727004815 substrate binding site [chemical binding]; other site 685727004816 metal binding site [ion binding]; metal-binding site 685727004817 putative acyltransferase; Provisional; Region: PRK05790 685727004818 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 685727004819 dimer interface [polypeptide binding]; other site 685727004820 active site 685727004821 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 685727004822 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 685727004823 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 685727004824 Predicted metalloprotease [General function prediction only]; Region: COG2321 685727004825 Domain of unknown function (DUF955); Region: DUF955; cl01076 685727004826 glycogen branching enzyme; Provisional; Region: PRK05402 685727004827 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 685727004828 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 685727004829 active site 685727004830 catalytic site [active] 685727004831 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 685727004832 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 685727004833 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 685727004834 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 685727004835 active site 685727004836 homodimer interface [polypeptide binding]; other site 685727004837 catalytic site [active] 685727004838 acceptor binding site [chemical binding]; other site 685727004839 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 685727004840 putative homodimer interface [polypeptide binding]; other site 685727004841 putative active site pocket [active] 685727004842 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 685727004843 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 685727004844 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 685727004845 inhibitor-cofactor binding pocket; inhibition site 685727004846 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685727004847 catalytic residue [active] 685727004848 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 685727004849 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 685727004850 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 685727004851 Walker A/P-loop; other site 685727004852 ATP binding site [chemical binding]; other site 685727004853 Q-loop/lid; other site 685727004854 ABC transporter signature motif; other site 685727004855 Walker B; other site 685727004856 D-loop; other site 685727004857 H-loop/switch region; other site 685727004858 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 685727004859 DEAD/DEAH box helicase; Region: DEAD; pfam00270 685727004860 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 685727004861 putative Mg++ binding site [ion binding]; other site 685727004862 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 685727004863 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 685727004864 Cytochrome P450; Region: p450; cl12078 685727004865 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727004866 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727004867 Isochorismatase family; Region: Isochorismatase; pfam00857 685727004868 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 685727004869 catalytic triad [active] 685727004870 metal binding site [ion binding]; metal-binding site 685727004871 conserved cis-peptide bond; other site 685727004872 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 685727004873 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 685727004874 active site 685727004875 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 685727004876 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 685727004877 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 685727004878 putative active site pocket [active] 685727004879 cleavage site 685727004880 Rhomboid family; Region: Rhomboid; pfam01694 685727004881 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 685727004882 ribonuclease PH; Reviewed; Region: rph; PRK00173 685727004883 Ribonuclease PH; Region: RNase_PH_bact; cd11362 685727004884 hexamer interface [polypeptide binding]; other site 685727004885 active site 685727004886 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 685727004887 active site 685727004888 dimerization interface [polypeptide binding]; other site 685727004889 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 685727004890 Glucitol operon activator protein (GutM); Region: GutM; cl01890 685727004891 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 685727004892 hypothetical protein; Provisional; Region: PRK02821 685727004893 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 685727004894 G-X-X-G motif; other site 685727004895 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 685727004896 RimM N-terminal domain; Region: RimM; pfam01782 685727004897 PRC-barrel domain; Region: PRC; pfam05239 685727004898 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 685727004899 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 685727004900 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 685727004901 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 685727004902 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 685727004903 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 685727004904 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 685727004905 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 685727004906 RNA binding site [nucleotide binding]; other site 685727004907 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 685727004908 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 685727004909 Uncharacterized conserved protein [Function unknown]; Region: COG1262 685727004910 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 685727004911 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 685727004912 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 685727004913 Catalytic site [active] 685727004914 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 685727004915 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 685727004916 RNA/DNA hybrid binding site [nucleotide binding]; other site 685727004917 active site 685727004918 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 685727004919 hypothetical protein; Reviewed; Region: PRK12497 685727004920 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 685727004921 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 685727004922 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685727004923 Walker A motif; other site 685727004924 ATP binding site [chemical binding]; other site 685727004925 Walker B motif; other site 685727004926 arginine finger; other site 685727004927 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 685727004928 DNA protecting protein DprA; Region: dprA; TIGR00732 685727004929 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 685727004930 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 685727004931 active site 685727004932 catalytic site [active] 685727004933 GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; Region: GIY-YIG_COG3680; cd10440 685727004934 GIY-YIG motif/motif A; other site 685727004935 putative active site [active] 685727004936 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 685727004937 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 685727004938 FAD binding pocket [chemical binding]; other site 685727004939 FAD binding motif [chemical binding]; other site 685727004940 phosphate binding motif [ion binding]; other site 685727004941 NAD binding pocket [chemical binding]; other site 685727004942 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727004943 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 685727004944 putative substrate translocation pore; other site 685727004945 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 685727004946 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 685727004947 active site 685727004948 DNA binding site [nucleotide binding] 685727004949 Int/Topo IB signature motif; other site 685727004950 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 685727004951 Peptidase family M23; Region: Peptidase_M23; pfam01551 685727004952 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 685727004953 rRNA interaction site [nucleotide binding]; other site 685727004954 S8 interaction site; other site 685727004955 putative laminin-1 binding site; other site 685727004956 elongation factor Ts; Provisional; Region: tsf; PRK09377 685727004957 UBA/TS-N domain; Region: UBA; pfam00627 685727004958 Elongation factor TS; Region: EF_TS; pfam00889 685727004959 Elongation factor TS; Region: EF_TS; pfam00889 685727004960 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 685727004961 putative nucleotide binding site [chemical binding]; other site 685727004962 uridine monophosphate binding site [chemical binding]; other site 685727004963 homohexameric interface [polypeptide binding]; other site 685727004964 ribosome recycling factor; Reviewed; Region: frr; PRK00083 685727004965 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 685727004966 hinge region; other site 685727004967 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 685727004968 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 685727004969 Methyltransferase domain; Region: Methyltransf_23; pfam13489 685727004970 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685727004971 S-adenosylmethionine binding site [chemical binding]; other site 685727004972 Secretory lipase; Region: LIP; pfam03583 685727004973 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 685727004974 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 685727004975 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 685727004976 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 685727004977 FeS/SAM binding site; other site 685727004978 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 685727004979 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 685727004980 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 685727004981 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 685727004982 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 685727004983 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 685727004984 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 685727004985 active site 685727004986 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 685727004987 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 685727004988 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 685727004989 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 685727004990 Predicted acetyltransferase [General function prediction only]; Region: COG3393 685727004991 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 685727004992 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 685727004993 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 685727004994 Flp/Fap pilin component; Region: Flp_Fap; cl01585 685727004995 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 685727004996 TadE-like protein; Region: TadE; pfam07811 685727004997 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 685727004998 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 685727004999 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 685727005000 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 685727005001 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 685727005002 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 685727005003 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 685727005004 ATP binding site [chemical binding]; other site 685727005005 Walker A motif; other site 685727005006 hexamer interface [polypeptide binding]; other site 685727005007 Walker B motif; other site 685727005008 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 685727005009 metal ion-dependent adhesion site (MIDAS); other site 685727005010 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 685727005011 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 685727005012 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 685727005013 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 685727005014 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 685727005015 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 685727005016 DNA binding residues [nucleotide binding] 685727005017 dimerization interface [polypeptide binding]; other site 685727005018 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 685727005019 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 685727005020 acyl-activating enzyme (AAE) consensus motif; other site 685727005021 AMP binding site [chemical binding]; other site 685727005022 active site 685727005023 CoA binding site [chemical binding]; other site 685727005024 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685727005025 dimer interface [polypeptide binding]; other site 685727005026 conserved gate region; other site 685727005027 ABC-ATPase subunit interface; other site 685727005028 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 685727005029 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685727005030 dimer interface [polypeptide binding]; other site 685727005031 conserved gate region; other site 685727005032 putative PBP binding loops; other site 685727005033 ABC-ATPase subunit interface; other site 685727005034 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 685727005035 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685727005036 Walker A/P-loop; other site 685727005037 ATP binding site [chemical binding]; other site 685727005038 Q-loop/lid; other site 685727005039 ABC transporter signature motif; other site 685727005040 Walker B; other site 685727005041 D-loop; other site 685727005042 H-loop/switch region; other site 685727005043 TOBE domain; Region: TOBE_2; pfam08402 685727005044 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 685727005045 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 685727005046 phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351 685727005047 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685727005048 motif II; other site 685727005049 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 685727005050 hydroxyglutarate oxidase; Provisional; Region: PRK11728 685727005051 Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl17564 685727005052 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 685727005053 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 685727005054 DNA-binding site [nucleotide binding]; DNA binding site 685727005055 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 685727005056 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 685727005057 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 685727005058 Sulfate transporter family; Region: Sulfate_transp; pfam00916 685727005059 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 685727005060 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 685727005061 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 685727005062 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 685727005063 active site 685727005064 cobyric acid synthase; Provisional; Region: PRK00784 685727005065 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 685727005066 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 685727005067 catalytic triad [active] 685727005068 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 685727005069 Beta-lactamase; Region: Beta-lactamase; pfam00144 685727005070 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 685727005071 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 685727005072 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 685727005073 Sulfate transporter family; Region: Sulfate_transp; pfam00916 685727005074 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 685727005075 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 685727005076 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 685727005077 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 685727005078 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 685727005079 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 685727005080 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 685727005081 Walker A/P-loop; other site 685727005082 ATP binding site [chemical binding]; other site 685727005083 Q-loop/lid; other site 685727005084 ABC transporter signature motif; other site 685727005085 Walker B; other site 685727005086 D-loop; other site 685727005087 H-loop/switch region; other site 685727005088 NIL domain; Region: NIL; pfam09383 685727005089 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685727005090 dimer interface [polypeptide binding]; other site 685727005091 conserved gate region; other site 685727005092 ABC-ATPase subunit interface; other site 685727005093 mycothione reductase; Reviewed; Region: PRK07846 685727005094 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 685727005095 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 685727005096 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 685727005097 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 685727005098 malate:quinone oxidoreductase; Validated; Region: PRK05257 685727005099 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 685727005100 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 685727005101 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685727005102 Walker A motif; other site 685727005103 ATP binding site [chemical binding]; other site 685727005104 Walker B motif; other site 685727005105 arginine finger; other site 685727005106 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 685727005107 metal ion-dependent adhesion site (MIDAS); other site 685727005108 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 685727005109 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 685727005110 Walker A motif; other site 685727005111 homodimer interface [polypeptide binding]; other site 685727005112 ATP binding site [chemical binding]; other site 685727005113 hydroxycobalamin binding site [chemical binding]; other site 685727005114 Walker B motif; other site 685727005115 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 685727005116 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 685727005117 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 685727005118 catalytic triad [active] 685727005119 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 685727005120 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 685727005121 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 685727005122 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 685727005123 active site 685727005124 SAM binding site [chemical binding]; other site 685727005125 homodimer interface [polypeptide binding]; other site 685727005126 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 685727005127 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727005128 putative substrate translocation pore; other site 685727005129 hypothetical protein; Validated; Region: PRK02101 685727005130 prolyl-tRNA synthetase; Provisional; Region: PRK09194 685727005131 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 685727005132 motif 1; other site 685727005133 dimer interface [polypeptide binding]; other site 685727005134 active site 685727005135 motif 2; other site 685727005136 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 685727005137 putative deacylase active site [active] 685727005138 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 685727005139 active site 685727005140 motif 3; other site 685727005141 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 685727005142 anticodon binding site; other site 685727005143 classical (c) SDRs; Region: SDR_c; cd05233 685727005144 NAD(P) binding site [chemical binding]; other site 685727005145 active site 685727005146 acyl-CoA synthetase; Validated; Region: PRK07788 685727005147 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 685727005148 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 685727005149 acyl-activating enzyme (AAE) consensus motif; other site 685727005150 AMP binding site [chemical binding]; other site 685727005151 active site 685727005152 CoA binding site [chemical binding]; other site 685727005153 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 685727005154 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 685727005155 NAD(P) binding site [chemical binding]; other site 685727005156 catalytic residues [active] 685727005157 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727005158 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727005159 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 685727005160 Cytochrome P450; Region: p450; cl12078 685727005161 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 685727005162 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 685727005163 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 685727005164 active site 685727005165 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 685727005166 Uncharacterized conserved protein [Function unknown]; Region: COG1434 685727005167 putative active site [active] 685727005168 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 685727005169 active site 685727005170 phosphorylation site [posttranslational modification] 685727005171 intermolecular recognition site; other site 685727005172 dimerization interface [polypeptide binding]; other site 685727005173 NADH dehydrogenase subunit A; Validated; Region: PRK07928 685727005174 NADH dehydrogenase subunit B; Validated; Region: PRK06411 685727005175 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 685727005176 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 685727005177 NADH dehydrogenase subunit D; Validated; Region: PRK06075 685727005178 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 685727005179 NADH dehydrogenase subunit E; Validated; Region: PRK07539 685727005180 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 685727005181 putative dimer interface [polypeptide binding]; other site 685727005182 [2Fe-2S] cluster binding site [ion binding]; other site 685727005183 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 685727005184 SLBB domain; Region: SLBB; pfam10531 685727005185 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 685727005186 NADH dehydrogenase subunit G; Validated; Region: PRK07860 685727005187 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 685727005188 catalytic loop [active] 685727005189 iron binding site [ion binding]; other site 685727005190 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 685727005191 MopB_NADH-Q-OR-NuoG2: The NuoG/Nad11/75-kDa subunit (second domain) of the NADH-quinone oxidoreductase (NADH-Q-OR)/respiratory complex I/NADH dehydrogenase-1 (NDH-1). The NADH-Q-OR is the first energy-transducting complex in the respiratory chains of...; Region: MopB_NADH-Q-OR-NuoG2; cd02768 685727005192 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 685727005193 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 685727005194 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 685727005195 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 685727005196 4Fe-4S binding domain; Region: Fer4; pfam00037 685727005197 4Fe-4S binding domain; Region: Fer4; pfam00037 685727005198 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 685727005199 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 685727005200 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 685727005201 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 685727005202 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 685727005203 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 685727005204 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 685727005205 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 685727005206 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 685727005207 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 685727005208 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 685727005209 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727005210 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727005211 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727005212 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727005213 SnoaL-like domain; Region: SnoaL_4; pfam13577 685727005214 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 685727005215 dinuclear metal binding motif [ion binding]; other site 685727005216 Sm and related proteins; Region: Sm_like; cl00259 685727005217 ribosome maturation protein RimP; Reviewed; Region: PRK00092 685727005218 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 685727005219 putative oligomer interface [polypeptide binding]; other site 685727005220 putative RNA binding site [nucleotide binding]; other site 685727005221 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 685727005222 NusA N-terminal domain; Region: NusA_N; pfam08529 685727005223 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 685727005224 RNA binding site [nucleotide binding]; other site 685727005225 homodimer interface [polypeptide binding]; other site 685727005226 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 685727005227 G-X-X-G motif; other site 685727005228 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 685727005229 G-X-X-G motif; other site 685727005230 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 685727005231 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 685727005232 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 685727005233 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 685727005234 G1 box; other site 685727005235 putative GEF interaction site [polypeptide binding]; other site 685727005236 GTP/Mg2+ binding site [chemical binding]; other site 685727005237 Switch I region; other site 685727005238 G2 box; other site 685727005239 G3 box; other site 685727005240 Switch II region; other site 685727005241 G4 box; other site 685727005242 G5 box; other site 685727005243 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 685727005244 Translation-initiation factor 2; Region: IF-2; pfam11987 685727005245 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 685727005246 Protein of unknown function (DUF503); Region: DUF503; pfam04456 685727005247 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 685727005248 DHH family; Region: DHH; pfam01368 685727005249 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 685727005250 DHHA1 domain; Region: DHHA1; pfam02272 685727005251 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 685727005252 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 685727005253 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 685727005254 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 685727005255 active site 685727005256 metal binding site [ion binding]; metal-binding site 685727005257 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 685727005258 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 685727005259 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 685727005260 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 685727005261 RNA binding site [nucleotide binding]; other site 685727005262 active site 685727005263 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 685727005264 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 685727005265 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 685727005266 putative DNA binding site [nucleotide binding]; other site 685727005267 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 685727005268 FeoA domain; Region: FeoA; pfam04023 685727005269 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 685727005270 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 685727005271 active site 685727005272 Riboflavin kinase; Region: Flavokinase; pfam01687 685727005273 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 685727005274 16S/18S rRNA binding site [nucleotide binding]; other site 685727005275 S13e-L30e interaction site [polypeptide binding]; other site 685727005276 25S rRNA binding site [nucleotide binding]; other site 685727005277 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 685727005278 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 685727005279 oligomer interface [polypeptide binding]; other site 685727005280 RNA binding site [nucleotide binding]; other site 685727005281 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 685727005282 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 685727005283 RNase E interface [polypeptide binding]; other site 685727005284 trimer interface [polypeptide binding]; other site 685727005285 active site 685727005286 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 685727005287 putative nucleic acid binding region [nucleotide binding]; other site 685727005288 G-X-X-G motif; other site 685727005289 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 685727005290 RNA binding site [nucleotide binding]; other site 685727005291 domain interface; other site 685727005292 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 685727005293 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 685727005294 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 685727005295 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 685727005296 Sulfatase; Region: Sulfatase; pfam00884 685727005297 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 685727005298 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 685727005299 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 685727005300 dihydrodipicolinate reductase; Provisional; Region: PRK00048 685727005301 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 685727005302 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 685727005303 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 685727005304 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 685727005305 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 685727005306 putative hydrophobic ligand binding site [chemical binding]; other site 685727005307 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 685727005308 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 685727005309 classical (c) SDRs; Region: SDR_c; cd05233 685727005310 NAD(P) binding site [chemical binding]; other site 685727005311 active site 685727005312 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 685727005313 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 685727005314 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 685727005315 dimer interface [polypeptide binding]; other site 685727005316 active site 685727005317 catalytic residue [active] 685727005318 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 685727005319 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 685727005320 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 685727005321 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 685727005322 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 685727005323 TIGR03085 family protein; Region: TIGR03085 685727005324 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 685727005325 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 685727005326 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 685727005327 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 685727005328 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 685727005329 YCII-related domain; Region: YCII; cl00999 685727005330 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 685727005331 Coenzyme A binding pocket [chemical binding]; other site 685727005332 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 685727005333 Competence-damaged protein; Region: CinA; pfam02464 685727005334 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 685727005335 non-specific DNA binding site [nucleotide binding]; other site 685727005336 salt bridge; other site 685727005337 sequence-specific DNA binding site [nucleotide binding]; other site 685727005338 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 685727005339 Cobalt transport protein; Region: CbiQ; cl00463 685727005340 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 685727005341 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 685727005342 Walker A/P-loop; other site 685727005343 ATP binding site [chemical binding]; other site 685727005344 Q-loop/lid; other site 685727005345 ABC transporter signature motif; other site 685727005346 Walker B; other site 685727005347 D-loop; other site 685727005348 BioY family; Region: BioY; pfam02632 685727005349 Transcriptional regulator [Transcription]; Region: LysR; COG0583 685727005350 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685727005351 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 685727005352 putative dimerization interface [polypeptide binding]; other site 685727005353 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 685727005354 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727005355 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 685727005356 diacylglycerol kinase; Reviewed; Region: PRK11914 685727005357 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 685727005358 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 685727005359 FAD binding domain; Region: FAD_binding_4; pfam01565 685727005360 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727005361 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727005362 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 685727005363 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 685727005364 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 685727005365 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 685727005366 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 685727005367 homodimer interface [polypeptide binding]; other site 685727005368 active site 685727005369 TDP-binding site; other site 685727005370 acceptor substrate-binding pocket; other site 685727005371 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 685727005372 recombinase A; Provisional; Region: recA; PRK09354 685727005373 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 685727005374 hexamer interface [polypeptide binding]; other site 685727005375 Walker A motif; other site 685727005376 ATP binding site [chemical binding]; other site 685727005377 Walker B motif; other site 685727005378 recombination regulator RecX; Reviewed; Region: recX; PRK00117 685727005379 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 685727005380 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685727005381 dimer interface [polypeptide binding]; other site 685727005382 conserved gate region; other site 685727005383 putative PBP binding loops; other site 685727005384 ABC-ATPase subunit interface; other site 685727005385 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 685727005386 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685727005387 dimer interface [polypeptide binding]; other site 685727005388 conserved gate region; other site 685727005389 putative PBP binding loops; other site 685727005390 ABC-ATPase subunit interface; other site 685727005391 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 685727005392 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 685727005393 substrate binding pocket [chemical binding]; other site 685727005394 membrane-bound complex binding site; other site 685727005395 hinge residues; other site 685727005396 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 685727005397 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 685727005398 Walker A/P-loop; other site 685727005399 ATP binding site [chemical binding]; other site 685727005400 Q-loop/lid; other site 685727005401 ABC transporter signature motif; other site 685727005402 Walker B; other site 685727005403 D-loop; other site 685727005404 H-loop/switch region; other site 685727005405 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 685727005406 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 685727005407 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 685727005408 FeS/SAM binding site; other site 685727005409 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 685727005410 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 685727005411 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 685727005412 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 685727005413 active site 685727005414 metal binding site [ion binding]; metal-binding site 685727005415 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 685727005416 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 685727005417 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 685727005418 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 685727005419 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 685727005420 GTPases [General function prediction only]; Region: HflX; COG2262 685727005421 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 685727005422 HflX GTPase family; Region: HflX; cd01878 685727005423 G1 box; other site 685727005424 GTP/Mg2+ binding site [chemical binding]; other site 685727005425 Switch I region; other site 685727005426 G2 box; other site 685727005427 G3 box; other site 685727005428 Switch II region; other site 685727005429 G4 box; other site 685727005430 G5 box; other site 685727005431 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 685727005432 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 685727005433 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 685727005434 active site 685727005435 LexA repressor; Validated; Region: PRK00215 685727005436 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 685727005437 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 685727005438 Catalytic site [active] 685727005439 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 685727005440 ATP cone domain; Region: ATP-cone; pfam03477 685727005441 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 685727005442 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 685727005443 ATP binding site [chemical binding]; other site 685727005444 putative Mg++ binding site [ion binding]; other site 685727005445 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 685727005446 nucleotide binding region [chemical binding]; other site 685727005447 ATP-binding site [chemical binding]; other site 685727005448 Helicase associated domain (HA2); Region: HA2; pfam04408 685727005449 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 685727005450 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 685727005451 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 685727005452 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 685727005453 inhibitor-cofactor binding pocket; inhibition site 685727005454 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685727005455 catalytic residue [active] 685727005456 Transcriptional regulators [Transcription]; Region: PurR; COG1609 685727005457 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 685727005458 DNA binding site [nucleotide binding] 685727005459 domain linker motif; other site 685727005460 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 685727005461 dimerization interface [polypeptide binding]; other site 685727005462 ligand binding site [chemical binding]; other site 685727005463 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 685727005464 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 685727005465 substrate binding site [chemical binding]; other site 685727005466 ATP binding site [chemical binding]; other site 685727005467 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 685727005468 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 685727005469 Walker A/P-loop; other site 685727005470 ATP binding site [chemical binding]; other site 685727005471 Q-loop/lid; other site 685727005472 ABC transporter signature motif; other site 685727005473 Walker B; other site 685727005474 D-loop; other site 685727005475 H-loop/switch region; other site 685727005476 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 685727005477 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 685727005478 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 685727005479 TM-ABC transporter signature motif; other site 685727005480 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 685727005481 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 685727005482 ligand binding site [chemical binding]; other site 685727005483 dimerization interface [polypeptide binding]; other site 685727005484 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 685727005485 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 685727005486 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 685727005487 Transcriptional regulator [Transcription]; Region: LysR; COG0583 685727005488 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685727005489 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 685727005490 dimerization interface [polypeptide binding]; other site 685727005491 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 685727005492 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 685727005493 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 685727005494 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 685727005495 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 685727005496 ATP binding site [chemical binding]; other site 685727005497 putative Mg++ binding site [ion binding]; other site 685727005498 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 685727005499 nucleotide binding region [chemical binding]; other site 685727005500 ATP-binding site [chemical binding]; other site 685727005501 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 685727005502 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 685727005503 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 685727005504 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 685727005505 nucleophilic elbow; other site 685727005506 catalytic triad; other site 685727005507 PAC2 family; Region: PAC2; pfam09754 685727005508 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 685727005509 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 685727005510 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 685727005511 NAD binding site [chemical binding]; other site 685727005512 homodimer interface [polypeptide binding]; other site 685727005513 active site 685727005514 substrate binding site [chemical binding]; other site 685727005515 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 685727005516 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 685727005517 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 685727005518 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 685727005519 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 685727005520 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 685727005521 active site 685727005522 Zn binding site [ion binding]; other site 685727005523 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 685727005524 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 685727005525 Coenzyme A binding pocket [chemical binding]; other site 685727005526 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 685727005527 CoA binding domain; Region: CoA_binding_2; pfam13380 685727005528 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 685727005529 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 685727005530 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 685727005531 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 685727005532 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 685727005533 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 685727005534 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 685727005535 DNA binding residues [nucleotide binding] 685727005536 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 685727005537 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685727005538 S-adenosylmethionine binding site [chemical binding]; other site 685727005539 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 685727005540 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 685727005541 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 685727005542 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 685727005543 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 685727005544 ATP binding site [chemical binding]; other site 685727005545 putative Mg++ binding site [ion binding]; other site 685727005546 Protein of unknown function (DUF952); Region: DUF952; cl01393 685727005547 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 685727005548 TrkA-C domain; Region: TrkA_C; pfam02080 685727005549 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 685727005550 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 685727005551 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 685727005552 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 685727005553 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 685727005554 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 685727005555 DNA binding residues [nucleotide binding] 685727005556 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 685727005557 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 685727005558 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 685727005559 active site 685727005560 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 685727005561 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 685727005562 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 685727005563 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 685727005564 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 685727005565 trimer interface [polypeptide binding]; other site 685727005566 active site 685727005567 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 685727005568 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 685727005569 ssDNA binding site; other site 685727005570 generic binding surface II; other site 685727005571 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 685727005572 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 685727005573 TrkA-N domain; Region: TrkA_N; pfam02254 685727005574 TrkA-C domain; Region: TrkA_C; pfam02080 685727005575 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 685727005576 TrkA-N domain; Region: TrkA_N; pfam02254 685727005577 TrkA-C domain; Region: TrkA_C; pfam02080 685727005578 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 685727005579 TRAM domain; Region: TRAM; pfam01938 685727005580 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 685727005581 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 685727005582 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 685727005583 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 685727005584 putative DNA binding site [nucleotide binding]; other site 685727005585 putative Zn2+ binding site [ion binding]; other site 685727005586 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727005587 Major Facilitator Superfamily; Region: MFS_1; pfam07690 685727005588 putative substrate translocation pore; other site 685727005589 ABC-2 type transporter; Region: ABC2_membrane; cl17235 685727005590 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 685727005591 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685727005592 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 685727005593 Walker A/P-loop; other site 685727005594 ATP binding site [chemical binding]; other site 685727005595 Q-loop/lid; other site 685727005596 ABC transporter signature motif; other site 685727005597 Walker B; other site 685727005598 D-loop; other site 685727005599 H-loop/switch region; other site 685727005600 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 685727005601 glutaminase; Provisional; Region: PRK00971 685727005602 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 685727005603 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 685727005604 ligand binding site [chemical binding]; other site 685727005605 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 685727005606 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 685727005607 TPP-binding site; other site 685727005608 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 685727005609 PYR/PP interface [polypeptide binding]; other site 685727005610 dimer interface [polypeptide binding]; other site 685727005611 TPP binding site [chemical binding]; other site 685727005612 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 685727005613 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 685727005614 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 685727005615 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 685727005616 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 685727005617 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 685727005618 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727005619 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727005620 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 685727005621 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 685727005622 siderophore binding site; other site 685727005623 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 685727005624 substrate binding site [chemical binding]; other site 685727005625 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 685727005626 oxyanion hole (OAH) forming residues; other site 685727005627 trimer interface [polypeptide binding]; other site 685727005628 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 685727005629 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 685727005630 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 685727005631 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 685727005632 dimer interface [polypeptide binding]; other site 685727005633 active site 685727005634 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 685727005635 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 685727005636 catalytic site [active] 685727005637 putative active site [active] 685727005638 putative substrate binding site [chemical binding]; other site 685727005639 Helicase and RNase D C-terminal; Region: HRDC; smart00341 685727005640 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 685727005641 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 685727005642 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 685727005643 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 685727005644 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 685727005645 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 685727005646 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 685727005647 substrate binding site [chemical binding]; other site 685727005648 active site 685727005649 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 685727005650 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 685727005651 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 685727005652 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 685727005653 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 685727005654 molybdopterin cofactor binding site [chemical binding]; other site 685727005655 substrate binding site [chemical binding]; other site 685727005656 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 685727005657 molybdopterin cofactor binding site; other site 685727005658 Predicted transcriptional regulators [Transcription]; Region: COG1725 685727005659 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 685727005660 DNA-binding site [nucleotide binding]; DNA binding site 685727005661 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 685727005662 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 685727005663 SelR domain; Region: SelR; pfam01641 685727005664 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 685727005665 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 685727005666 TAP-like protein; Region: Abhydrolase_4; pfam08386 685727005667 hypothetical protein; Provisional; Region: PRK14059 685727005668 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 685727005669 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 685727005670 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 685727005671 Walker A motif; other site 685727005672 ATP binding site [chemical binding]; other site 685727005673 Walker B motif; other site 685727005674 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 685727005675 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 685727005676 Coenzyme A binding pocket [chemical binding]; other site 685727005677 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727005678 Major Facilitator Superfamily; Region: MFS_1; pfam07690 685727005679 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 685727005680 beta-galactosidase; Region: BGL; TIGR03356 685727005681 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 685727005682 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 685727005683 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 685727005684 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 685727005685 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 685727005686 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 685727005687 active site 685727005688 dimer interface [polypeptide binding]; other site 685727005689 motif 1; other site 685727005690 motif 2; other site 685727005691 motif 3; other site 685727005692 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 685727005693 anticodon binding site; other site 685727005694 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 685727005695 nucleotide binding site/active site [active] 685727005696 HIT family signature motif; other site 685727005697 catalytic residue [active] 685727005698 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 685727005699 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 685727005700 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 685727005701 putative acyl-acceptor binding pocket; other site 685727005702 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 685727005703 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 685727005704 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 685727005705 nudix motif; other site 685727005706 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 685727005707 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 685727005708 active site 685727005709 multimer interface [polypeptide binding]; other site 685727005710 acyl-CoA thioesterase II; Region: tesB; TIGR00189 685727005711 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 685727005712 active site 685727005713 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 685727005714 catalytic triad [active] 685727005715 dimer interface [polypeptide binding]; other site 685727005716 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 685727005717 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13143 685727005718 predicted active site [active] 685727005719 catalytic triad [active] 685727005720 Putative esterase; Region: Esterase; pfam00756 685727005721 hypothetical protein; Validated; Region: PRK00110 685727005722 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 685727005723 active site 685727005724 putative DNA-binding cleft [nucleotide binding]; other site 685727005725 dimer interface [polypeptide binding]; other site 685727005726 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 685727005727 RuvA N terminal domain; Region: RuvA_N; pfam01330 685727005728 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 685727005729 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 685727005730 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685727005731 Walker A motif; other site 685727005732 ATP binding site [chemical binding]; other site 685727005733 Walker B motif; other site 685727005734 arginine finger; other site 685727005735 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 685727005736 Preprotein translocase subunit; Region: YajC; cl00806 685727005737 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 685727005738 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 685727005739 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 685727005740 Protein export membrane protein; Region: SecD_SecF; pfam02355 685727005741 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 685727005742 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 685727005743 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 685727005744 active site 685727005745 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 685727005746 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 685727005747 Zn2+ binding site [ion binding]; other site 685727005748 Mg2+ binding site [ion binding]; other site 685727005749 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 685727005750 synthetase active site [active] 685727005751 NTP binding site [chemical binding]; other site 685727005752 metal binding site [ion binding]; metal-binding site 685727005753 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 685727005754 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 685727005755 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 685727005756 active site 685727005757 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 685727005758 active site 685727005759 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 685727005760 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 685727005761 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 685727005762 dimer interface [polypeptide binding]; other site 685727005763 motif 1; other site 685727005764 active site 685727005765 motif 2; other site 685727005766 motif 3; other site 685727005767 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 685727005768 anticodon binding site; other site 685727005769 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 685727005770 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 685727005771 DNA binding residues [nucleotide binding] 685727005772 dimerization interface [polypeptide binding]; other site 685727005773 malate dehydrogenase; Provisional; Region: PRK05442 685727005774 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 685727005775 NAD(P) binding site [chemical binding]; other site 685727005776 dimer interface [polypeptide binding]; other site 685727005777 malate binding site [chemical binding]; other site 685727005778 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727005779 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727005780 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 685727005781 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 685727005782 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 685727005783 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 685727005784 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 685727005785 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 685727005786 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 685727005787 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727005788 Major Facilitator Superfamily; Region: MFS_1; pfam07690 685727005789 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727005790 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727005791 Transcriptional regulator [Transcription]; Region: LysR; COG0583 685727005792 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685727005793 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 685727005794 dimerization interface [polypeptide binding]; other site 685727005795 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 685727005796 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727005797 NAD(P) binding site [chemical binding]; other site 685727005798 active site 685727005799 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 685727005800 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 685727005801 NAD(P) binding site [chemical binding]; other site 685727005802 catalytic residues [active] 685727005803 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 685727005804 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685727005805 Walker A motif; other site 685727005806 ATP binding site [chemical binding]; other site 685727005807 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 685727005808 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 685727005809 DNA binding residues [nucleotide binding] 685727005810 additional locus_tag=REQ_21210 685727005811 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 685727005812 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 685727005813 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 685727005814 Multicopper oxidase; Region: Cu-oxidase; pfam00394 685727005815 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 685727005816 Peptidase family M48; Region: Peptidase_M48; cl12018 685727005817 Penicillinase repressor; Region: Pencillinase_R; pfam03965 685727005818 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 685727005819 Peptidase family M23; Region: Peptidase_M23; pfam01551 685727005820 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 685727005821 homotrimer interaction site [polypeptide binding]; other site 685727005822 putative active site [active] 685727005823 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 685727005824 Radical SAM superfamily; Region: Radical_SAM; pfam04055 685727005825 FeS/SAM binding site; other site 685727005826 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 685727005827 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 685727005828 dimer interface [polypeptide binding]; other site 685727005829 active site 685727005830 Domain of unknown function DUF20; Region: UPF0118; pfam01594 685727005831 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 685727005832 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 685727005833 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 685727005834 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 685727005835 acyl-activating enzyme (AAE) consensus motif; other site 685727005836 putative AMP binding site [chemical binding]; other site 685727005837 putative active site [active] 685727005838 putative CoA binding site [chemical binding]; other site 685727005839 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 685727005840 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 685727005841 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 685727005842 dimer interface [polypeptide binding]; other site 685727005843 anticodon binding site; other site 685727005844 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 685727005845 homodimer interface [polypeptide binding]; other site 685727005846 motif 1; other site 685727005847 active site 685727005848 motif 2; other site 685727005849 GAD domain; Region: GAD; pfam02938 685727005850 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 685727005851 active site 685727005852 motif 3; other site 685727005853 Domain of unknown function (DUF389); Region: DUF389; cl00781 685727005854 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 685727005855 active site 685727005856 ATP binding site [chemical binding]; other site 685727005857 substrate binding site [chemical binding]; other site 685727005858 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727005859 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727005860 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 685727005861 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 685727005862 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 685727005863 Walker A/P-loop; other site 685727005864 ATP binding site [chemical binding]; other site 685727005865 Q-loop/lid; other site 685727005866 ABC transporter signature motif; other site 685727005867 Walker B; other site 685727005868 D-loop; other site 685727005869 H-loop/switch region; other site 685727005870 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 685727005871 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 685727005872 Walker A/P-loop; other site 685727005873 ATP binding site [chemical binding]; other site 685727005874 Q-loop/lid; other site 685727005875 ABC transporter signature motif; other site 685727005876 Walker B; other site 685727005877 D-loop; other site 685727005878 H-loop/switch region; other site 685727005879 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 685727005880 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 685727005881 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685727005882 dimer interface [polypeptide binding]; other site 685727005883 conserved gate region; other site 685727005884 putative PBP binding loops; other site 685727005885 ABC-ATPase subunit interface; other site 685727005886 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 685727005887 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685727005888 dimer interface [polypeptide binding]; other site 685727005889 conserved gate region; other site 685727005890 putative PBP binding loops; other site 685727005891 ABC-ATPase subunit interface; other site 685727005892 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 685727005893 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 685727005894 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 685727005895 Sulfatase; Region: Sulfatase; pfam00884 685727005896 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 685727005897 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 685727005898 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 685727005899 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 685727005900 active site 685727005901 iron coordination sites [ion binding]; other site 685727005902 substrate binding pocket [chemical binding]; other site 685727005903 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727005904 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727005905 recombination factor protein RarA; Reviewed; Region: PRK13342 685727005906 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685727005907 Walker A motif; other site 685727005908 ATP binding site [chemical binding]; other site 685727005909 Walker B motif; other site 685727005910 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 685727005911 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 685727005912 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 685727005913 motif 1; other site 685727005914 active site 685727005915 motif 2; other site 685727005916 motif 3; other site 685727005917 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 685727005918 DHHA1 domain; Region: DHHA1; pfam02272 685727005919 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 685727005920 YceG-like family; Region: YceG; pfam02618 685727005921 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 685727005922 dimerization interface [polypeptide binding]; other site 685727005923 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 685727005924 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 685727005925 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 685727005926 shikimate binding site; other site 685727005927 NAD(P) binding site [chemical binding]; other site 685727005928 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 685727005929 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 685727005930 Tetramer interface [polypeptide binding]; other site 685727005931 active site 685727005932 FMN-binding site [chemical binding]; other site 685727005933 shikimate kinase; Reviewed; Region: aroK; PRK00131 685727005934 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 685727005935 ADP binding site [chemical binding]; other site 685727005936 magnesium binding site [ion binding]; other site 685727005937 putative shikimate binding site; other site 685727005938 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 685727005939 active site 685727005940 dimer interface [polypeptide binding]; other site 685727005941 metal binding site [ion binding]; metal-binding site 685727005942 Dehydroquinase class II; Region: DHquinase_II; pfam01220 685727005943 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 685727005944 trimer interface [polypeptide binding]; other site 685727005945 active site 685727005946 dimer interface [polypeptide binding]; other site 685727005947 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 685727005948 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 685727005949 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 685727005950 active site 685727005951 elongation factor P; Validated; Region: PRK00529 685727005952 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 685727005953 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 685727005954 RNA binding site [nucleotide binding]; other site 685727005955 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 685727005956 RNA binding site [nucleotide binding]; other site 685727005957 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 685727005958 putative RNA binding site [nucleotide binding]; other site 685727005959 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 685727005960 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 685727005961 active site 685727005962 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 685727005963 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 685727005964 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 685727005965 dihydroorotase; Validated; Region: pyrC; PRK09357 685727005966 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 685727005967 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 685727005968 active site 685727005969 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 685727005970 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 685727005971 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 685727005972 catalytic site [active] 685727005973 subunit interface [polypeptide binding]; other site 685727005974 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 685727005975 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 685727005976 ATP-grasp domain; Region: ATP-grasp_4; cl17255 685727005977 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 685727005978 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 685727005979 ATP-grasp domain; Region: ATP-grasp_4; cl17255 685727005980 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 685727005981 IMP binding site; other site 685727005982 dimer interface [polypeptide binding]; other site 685727005983 interdomain contacts; other site 685727005984 partial ornithine binding site; other site 685727005985 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 685727005986 active site 685727005987 dimer interface [polypeptide binding]; other site 685727005988 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 685727005989 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 685727005990 catalytic site [active] 685727005991 G-X2-G-X-G-K; other site 685727005992 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 685727005993 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 685727005994 Flavoprotein; Region: Flavoprotein; pfam02441 685727005995 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 685727005996 S-adenosylmethionine synthetase; Validated; Region: PRK05250 685727005997 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 685727005998 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 685727005999 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 685727006000 primosome assembly protein PriA; Provisional; Region: PRK14873 685727006001 EthD domain; Region: EthD; pfam07110 685727006002 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 685727006003 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 685727006004 oligomer interface [polypeptide binding]; other site 685727006005 metal binding site [ion binding]; metal-binding site 685727006006 metal binding site [ion binding]; metal-binding site 685727006007 putative Cl binding site [ion binding]; other site 685727006008 basic sphincter; other site 685727006009 hydrophobic gate; other site 685727006010 periplasmic entrance; other site 685727006011 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 685727006012 Lipase (class 2); Region: Lipase_2; pfam01674 685727006013 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 685727006014 Predicted membrane protein [Function unknown]; Region: COG4425 685727006015 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 685727006016 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 685727006017 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 685727006018 putative active site [active] 685727006019 substrate binding site [chemical binding]; other site 685727006020 putative cosubstrate binding site; other site 685727006021 catalytic site [active] 685727006022 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 685727006023 substrate binding site [chemical binding]; other site 685727006024 16S rRNA methyltransferase B; Provisional; Region: PRK14902 685727006025 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 685727006026 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 685727006027 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 685727006028 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 685727006029 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 685727006030 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 685727006031 active site 685727006032 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 685727006033 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 685727006034 putative phosphoketolase; Provisional; Region: PRK05261 685727006035 XFP N-terminal domain; Region: XFP_N; pfam09364 685727006036 XFP C-terminal domain; Region: XFP_C; pfam09363 685727006037 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 685727006038 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 685727006039 NAD(P) binding site [chemical binding]; other site 685727006040 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 685727006041 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 685727006042 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 685727006043 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 685727006044 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 685727006045 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 685727006046 substrate binding site [chemical binding]; other site 685727006047 hexamer interface [polypeptide binding]; other site 685727006048 metal binding site [ion binding]; metal-binding site 685727006049 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 685727006050 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 685727006051 catalytic motif [active] 685727006052 Zn binding site [ion binding]; other site 685727006053 RibD C-terminal domain; Region: RibD_C; pfam01872 685727006054 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 685727006055 Lumazine binding domain; Region: Lum_binding; pfam00677 685727006056 Lumazine binding domain; Region: Lum_binding; pfam00677 685727006057 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 685727006058 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 685727006059 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 685727006060 dimerization interface [polypeptide binding]; other site 685727006061 active site 685727006062 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 685727006063 homopentamer interface [polypeptide binding]; other site 685727006064 active site 685727006065 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 685727006066 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 685727006067 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 685727006068 GIY-YIG motif/motif A; other site 685727006069 active site 685727006070 catalytic site [active] 685727006071 putative DNA binding site [nucleotide binding]; other site 685727006072 metal binding site [ion binding]; metal-binding site 685727006073 UvrB/uvrC motif; Region: UVR; pfam02151 685727006074 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 685727006075 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 685727006076 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 685727006077 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 685727006078 phosphate binding site [ion binding]; other site 685727006079 putative substrate binding pocket [chemical binding]; other site 685727006080 dimer interface [polypeptide binding]; other site 685727006081 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 685727006082 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 685727006083 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 685727006084 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 685727006085 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 685727006086 Phosphoglycerate kinase; Region: PGK; pfam00162 685727006087 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 685727006088 substrate binding site [chemical binding]; other site 685727006089 hinge regions; other site 685727006090 ADP binding site [chemical binding]; other site 685727006091 catalytic site [active] 685727006092 triosephosphate isomerase; Provisional; Region: PRK14567 685727006093 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 685727006094 substrate binding site [chemical binding]; other site 685727006095 dimer interface [polypeptide binding]; other site 685727006096 catalytic triad [active] 685727006097 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 685727006098 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 685727006099 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 685727006100 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 685727006101 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 685727006102 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 685727006103 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 685727006104 Transcriptional regulators [Transcription]; Region: MarR; COG1846 685727006105 MarR family; Region: MarR_2; cl17246 685727006106 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 685727006107 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 685727006108 nucleophilic elbow; other site 685727006109 catalytic triad; other site 685727006110 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 685727006111 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 685727006112 putative active site [active] 685727006113 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 685727006114 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 685727006115 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 685727006116 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 685727006117 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 685727006118 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 685727006119 putative active site [active] 685727006120 catalytic residue [active] 685727006121 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 685727006122 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 685727006123 TPP-binding site [chemical binding]; other site 685727006124 dimer interface [polypeptide binding]; other site 685727006125 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 685727006126 PYR/PP interface [polypeptide binding]; other site 685727006127 dimer interface [polypeptide binding]; other site 685727006128 TPP binding site [chemical binding]; other site 685727006129 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 685727006130 UbiA prenyltransferase family; Region: UbiA; pfam01040 685727006131 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 685727006132 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 685727006133 NADP binding site [chemical binding]; other site 685727006134 dimer interface [polypeptide binding]; other site 685727006135 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 685727006136 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 685727006137 ABC-2 type transporter; Region: ABC2_membrane; cl17235 685727006138 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 685727006139 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 685727006140 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 685727006141 Walker A/P-loop; other site 685727006142 ATP binding site [chemical binding]; other site 685727006143 Q-loop/lid; other site 685727006144 ABC transporter signature motif; other site 685727006145 Walker B; other site 685727006146 D-loop; other site 685727006147 H-loop/switch region; other site 685727006148 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 685727006149 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 685727006150 putative DNA binding site [nucleotide binding]; other site 685727006151 Predicted transcriptional regulator [Transcription]; Region: COG2345 685727006152 putative Zn2+ binding site [ion binding]; other site 685727006153 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 685727006154 FeS assembly protein SufB; Region: sufB; TIGR01980 685727006155 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 685727006156 FeS assembly protein SufD; Region: sufD; TIGR01981 685727006157 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 685727006158 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 685727006159 Walker A/P-loop; other site 685727006160 ATP binding site [chemical binding]; other site 685727006161 Q-loop/lid; other site 685727006162 ABC transporter signature motif; other site 685727006163 Walker B; other site 685727006164 D-loop; other site 685727006165 H-loop/switch region; other site 685727006166 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 685727006167 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 685727006168 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 685727006169 catalytic residue [active] 685727006170 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 685727006171 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 685727006172 trimerization site [polypeptide binding]; other site 685727006173 active site 685727006174 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 685727006175 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 685727006176 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 685727006177 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 685727006178 putative DNA binding site [nucleotide binding]; other site 685727006179 putative homodimer interface [polypeptide binding]; other site 685727006180 Uncharacterized conserved protein [Function unknown]; Region: COG3379 685727006181 BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463 685727006182 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 685727006183 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 685727006184 classical (c) SDRs; Region: SDR_c; cd05233 685727006185 NAD(P) binding site [chemical binding]; other site 685727006186 active site 685727006187 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 685727006188 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685727006189 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685727006190 Walker A/P-loop; other site 685727006191 Walker A/P-loop; other site 685727006192 ATP binding site [chemical binding]; other site 685727006193 ATP binding site [chemical binding]; other site 685727006194 Q-loop/lid; other site 685727006195 Q-loop/lid; other site 685727006196 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 685727006197 ABC transporter signature motif; other site 685727006198 Walker B; other site 685727006199 D-loop; other site 685727006200 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 685727006201 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727006202 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727006203 aconitate hydratase; Validated; Region: PRK09277 685727006204 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 685727006205 substrate binding site [chemical binding]; other site 685727006206 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 685727006207 ligand binding site [chemical binding]; other site 685727006208 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 685727006209 substrate binding site [chemical binding]; other site 685727006210 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 685727006211 NlpC/P60 family; Region: NLPC_P60; pfam00877 685727006212 MoxR-like ATPases [General function prediction only]; Region: COG0714 685727006213 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685727006214 Walker A motif; other site 685727006215 ATP binding site [chemical binding]; other site 685727006216 Walker B motif; other site 685727006217 arginine finger; other site 685727006218 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 685727006219 Protein of unknown function DUF58; Region: DUF58; pfam01882 685727006220 hypothetical protein; Provisional; Region: PRK13685 685727006221 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 685727006222 von Willebrand factor type A domain; Region: VWA_2; pfam13519 685727006223 metal ion-dependent adhesion site (MIDAS); other site 685727006224 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 685727006225 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 685727006226 NAD(P) binding site [chemical binding]; other site 685727006227 homotetramer interface [polypeptide binding]; other site 685727006228 homodimer interface [polypeptide binding]; other site 685727006229 active site 685727006230 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 685727006231 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727006232 NAD(P) binding site [chemical binding]; other site 685727006233 active site 685727006234 ferrochelatase; Reviewed; Region: hemH; PRK00035 685727006235 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 685727006236 C-terminal domain interface [polypeptide binding]; other site 685727006237 active site 685727006238 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 685727006239 active site 685727006240 N-terminal domain interface [polypeptide binding]; other site 685727006241 salt bridge; other site 685727006242 non-specific DNA binding site [nucleotide binding]; other site 685727006243 Helix-turn-helix; Region: HTH_3; pfam01381 685727006244 sequence-specific DNA binding site [nucleotide binding]; other site 685727006245 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 685727006246 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 685727006247 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 685727006248 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 685727006249 Uncharacterized conserved protein [Function unknown]; Region: COG0398 685727006250 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 685727006251 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 685727006252 CoenzymeA binding site [chemical binding]; other site 685727006253 subunit interaction site [polypeptide binding]; other site 685727006254 PHB binding site; other site 685727006255 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 685727006256 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 685727006257 heterodimer interface [polypeptide binding]; other site 685727006258 substrate interaction site [chemical binding]; other site 685727006259 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 685727006260 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 685727006261 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 685727006262 active site 685727006263 substrate binding site [chemical binding]; other site 685727006264 coenzyme B12 binding site [chemical binding]; other site 685727006265 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 685727006266 B12 binding site [chemical binding]; other site 685727006267 cobalt ligand [ion binding]; other site 685727006268 membrane ATPase/protein kinase; Provisional; Region: PRK09435 685727006269 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 685727006270 Walker A; other site 685727006271 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 685727006272 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 685727006273 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727006274 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727006275 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 685727006276 active site 685727006277 Organic hydroperoxide reductase [Secondary metabolites biosynthesis, transport and catabolism]; Region: osmC; COG1764 685727006278 YhhN-like protein; Region: YhhN; pfam07947 685727006279 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 685727006280 CoA-transferase family III; Region: CoA_transf_3; pfam02515 685727006281 Protein of unknown function (DUF664); Region: DUF664; pfam04978 685727006282 DinB superfamily; Region: DinB_2; pfam12867 685727006283 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 685727006284 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 685727006285 putative active site [active] 685727006286 putative dimer interface [polypeptide binding]; other site 685727006287 Uncharacterized conserved protein [Function unknown]; Region: COG3268 685727006288 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 685727006289 NAD(P) binding pocket [chemical binding]; other site 685727006290 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 685727006291 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 685727006292 Ligand Binding Site [chemical binding]; other site 685727006293 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727006294 NAD(P) binding site [chemical binding]; other site 685727006295 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 685727006296 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727006297 active site 685727006298 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 685727006299 active site 685727006300 catalytic residues [active] 685727006301 hypothetical protein; Provisional; Region: PRK07906 685727006302 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 685727006303 putative metal binding site [ion binding]; other site 685727006304 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 685727006305 substrate binding site [chemical binding]; other site 685727006306 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 685727006307 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 685727006308 quinone interaction residues [chemical binding]; other site 685727006309 active site 685727006310 catalytic residues [active] 685727006311 FMN binding site [chemical binding]; other site 685727006312 substrate binding site [chemical binding]; other site 685727006313 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 685727006314 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 685727006315 Walker A/P-loop; other site 685727006316 ATP binding site [chemical binding]; other site 685727006317 Q-loop/lid; other site 685727006318 ABC transporter signature motif; other site 685727006319 Walker B; other site 685727006320 D-loop; other site 685727006321 H-loop/switch region; other site 685727006322 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 685727006323 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 685727006324 ABC-ATPase subunit interface; other site 685727006325 dimer interface [polypeptide binding]; other site 685727006326 putative PBP binding regions; other site 685727006327 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 685727006328 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 685727006329 intersubunit interface [polypeptide binding]; other site 685727006330 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 685727006331 heme binding pocket [chemical binding]; other site 685727006332 heme ligand [chemical binding]; other site 685727006333 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 685727006334 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 685727006335 active site 685727006336 catalytic tetrad [active] 685727006337 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 685727006338 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 685727006339 catalytic core [active] 685727006340 Protein of unknown function (DUF3090); Region: DUF3090; pfam11290 685727006341 conserved hypothetical protein; Region: TIGR03843 685727006342 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 685727006343 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 685727006344 putative Zn2+ binding site [ion binding]; other site 685727006345 putative DNA binding site [nucleotide binding]; other site 685727006346 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 685727006347 cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Region: mycothiol_MshC; TIGR03447 685727006348 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 685727006349 active site 685727006350 HIGH motif; other site 685727006351 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 685727006352 active site 685727006353 KMSKS motif; other site 685727006354 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 685727006355 putative tRNA binding surface [nucleotide binding]; other site 685727006356 putative acetyltransferase; Provisional; Region: PRK03624 685727006357 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 685727006358 Coenzyme A binding pocket [chemical binding]; other site 685727006359 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685727006360 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 685727006361 Walker A motif; other site 685727006362 ATP binding site [chemical binding]; other site 685727006363 Walker B motif; other site 685727006364 arginine finger; other site 685727006365 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 685727006366 nucleoside/Zn binding site; other site 685727006367 dimer interface [polypeptide binding]; other site 685727006368 catalytic motif [active] 685727006369 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 685727006370 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 685727006371 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 685727006372 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 685727006373 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 685727006374 catalytic residue [active] 685727006375 TIGR02680 family protein; Region: TIGR02680 685727006376 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 685727006377 Protein of unknown function (DUF2398); Region: DUF2398; cl09875 685727006378 TIGR02677 family protein; Region: TIGR02677 685727006379 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 685727006380 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 685727006381 PAC2 family; Region: PAC2; pfam09754 685727006382 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 685727006383 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 685727006384 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 685727006385 substrate binding pocket [chemical binding]; other site 685727006386 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 685727006387 B12 binding site [chemical binding]; other site 685727006388 cobalt ligand [ion binding]; other site 685727006389 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 685727006390 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 685727006391 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685727006392 motif II; other site 685727006393 hypothetical protein; Validated; Region: PRK01415 685727006394 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 685727006395 active site residue [active] 685727006396 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 685727006397 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 685727006398 active site 685727006399 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 685727006400 homodimer interface [polypeptide binding]; other site 685727006401 putative metal binding site [ion binding]; other site 685727006402 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 685727006403 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 685727006404 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 685727006405 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 685727006406 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 685727006407 active site 2 [active] 685727006408 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 685727006409 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 685727006410 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685727006411 S-adenosylmethionine binding site [chemical binding]; other site 685727006412 SnoaL-like domain; Region: SnoaL_2; pfam12680 685727006413 proteasome ATPase; Region: pup_AAA; TIGR03689 685727006414 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685727006415 Walker A motif; other site 685727006416 ATP binding site [chemical binding]; other site 685727006417 Walker B motif; other site 685727006418 arginine finger; other site 685727006419 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 685727006420 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 685727006421 nudix motif; other site 685727006422 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 685727006423 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 685727006424 DNA binding residues [nucleotide binding] 685727006425 putative dimer interface [polypeptide binding]; other site 685727006426 HEAT repeats; Region: HEAT_2; pfam13646 685727006427 HEAT repeats; Region: HEAT_2; pfam13646 685727006428 Domain of unknown function (DUF385); Region: DUF385; cl04387 685727006429 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 685727006430 Pup-like protein; Region: Pup; cl05289 685727006431 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 685727006432 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 685727006433 active site 685727006434 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 685727006435 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 685727006436 active site 685727006437 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 685727006438 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 685727006439 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 685727006440 Predicted transcriptional regulator [Transcription]; Region: COG2378 685727006441 WYL domain; Region: WYL; pfam13280 685727006442 Predicted transcriptional regulator [Transcription]; Region: COG2378 685727006443 WYL domain; Region: WYL; pfam13280 685727006444 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 685727006445 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 685727006446 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 685727006447 DEAD-like helicases superfamily; Region: DEXDc; smart00487 685727006448 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 685727006449 ATP binding site [chemical binding]; other site 685727006450 putative Mg++ binding site [ion binding]; other site 685727006451 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 685727006452 nucleotide binding region [chemical binding]; other site 685727006453 ATP-binding site [chemical binding]; other site 685727006454 rRNA-processing arch domain; Region: rRNA_proc-arch; pfam13234 685727006455 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 685727006456 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 685727006457 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 685727006458 5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739 685727006459 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 685727006460 active site 685727006461 metal binding site 1 [ion binding]; metal-binding site 685727006462 putative 5' ssDNA interaction site; other site 685727006463 metal binding site 3; metal-binding site 685727006464 metal binding site 2 [ion binding]; metal-binding site 685727006465 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 685727006466 putative DNA binding site [nucleotide binding]; other site 685727006467 putative metal binding site [ion binding]; other site 685727006468 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 685727006469 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 685727006470 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 685727006471 active site 685727006472 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 685727006473 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727006474 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 685727006475 NAD(P) binding site [chemical binding]; other site 685727006476 active site 685727006477 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 685727006478 active site 685727006479 putative homodimer interface [polypeptide binding]; other site 685727006480 SAM binding site [chemical binding]; other site 685727006481 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 685727006482 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469 685727006483 S-adenosylmethionine binding site [chemical binding]; other site 685727006484 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 685727006485 active site 685727006486 SAM binding site [chemical binding]; other site 685727006487 homodimer interface [polypeptide binding]; other site 685727006488 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 685727006489 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 685727006490 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 685727006491 classical (c) SDRs; Region: SDR_c; cd05233 685727006492 NAD(P) binding site [chemical binding]; other site 685727006493 active site 685727006494 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 685727006495 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 685727006496 Transcriptional regulators [Transcription]; Region: FadR; COG2186 685727006497 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 685727006498 DNA-binding site [nucleotide binding]; DNA binding site 685727006499 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 685727006500 active site 685727006501 SAM binding site [chemical binding]; other site 685727006502 homodimer interface [polypeptide binding]; other site 685727006503 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 685727006504 active site 685727006505 SAM binding site [chemical binding]; other site 685727006506 homodimer interface [polypeptide binding]; other site 685727006507 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 685727006508 Precorrin-8X methylmutase; Region: CbiC; pfam02570 685727006509 precorrin-3B synthase; Region: CobG; TIGR02435 685727006510 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 685727006511 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 685727006512 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 685727006513 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 685727006514 RibD C-terminal domain; Region: RibD_C; cl17279 685727006515 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 685727006516 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 685727006517 phosphopeptide binding site; other site 685727006518 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 685727006519 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 685727006520 phosphopeptide binding site; other site 685727006521 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 685727006522 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 685727006523 Walker A/P-loop; other site 685727006524 ATP binding site [chemical binding]; other site 685727006525 Q-loop/lid; other site 685727006526 ABC transporter signature motif; other site 685727006527 Walker B; other site 685727006528 D-loop; other site 685727006529 H-loop/switch region; other site 685727006530 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 685727006531 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 685727006532 Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain; Region: MPP_ACP5; cd07378 685727006533 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 685727006534 active site 685727006535 metal binding site [ion binding]; metal-binding site 685727006536 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 685727006537 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 685727006538 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 685727006539 DNA binding site [nucleotide binding] 685727006540 dimer interface [polypeptide binding]; other site 685727006541 active site 685727006542 Int/Topo IB signature motif; other site 685727006543 Lipase maturation factor; Region: LMF1; pfam06762 685727006544 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 685727006545 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 685727006546 hypothetical protein; Provisional; Region: PRK04233 685727006547 SEC-C motif; Region: SEC-C; pfam02810 685727006548 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 685727006549 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 685727006550 Uncharacterized conserved protein [Function unknown]; Region: COG5361 685727006551 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 685727006552 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 685727006553 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727006554 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727006555 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 685727006556 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 685727006557 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 685727006558 active site 685727006559 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 685727006560 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 685727006561 putative active site [active] 685727006562 catalytic triad [active] 685727006563 putative dimer interface [polypeptide binding]; other site 685727006564 MbtH-like protein; Region: MbtH; pfam03621 685727006565 Condensation domain; Region: Condensation; pfam00668 685727006566 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 685727006567 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 685727006568 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 685727006569 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 685727006570 acyl-activating enzyme (AAE) consensus motif; other site 685727006571 AMP binding site [chemical binding]; other site 685727006572 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 685727006573 Condensation domain; Region: Condensation; pfam00668 685727006574 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 685727006575 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 685727006576 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 685727006577 acyl-activating enzyme (AAE) consensus motif; other site 685727006578 AMP binding site [chemical binding]; other site 685727006579 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 685727006580 peptide synthase; Provisional; Region: PRK12316 685727006581 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 685727006582 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 685727006583 acyl-activating enzyme (AAE) consensus motif; other site 685727006584 AMP binding site [chemical binding]; other site 685727006585 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 685727006586 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 685727006587 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 685727006588 acyl-activating enzyme (AAE) consensus motif; other site 685727006589 AMP binding site [chemical binding]; other site 685727006590 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 685727006591 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 685727006592 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 685727006593 acyl-activating enzyme (AAE) consensus motif; other site 685727006594 AMP binding site [chemical binding]; other site 685727006595 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 685727006596 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 685727006597 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 685727006598 acyl-activating enzyme (AAE) consensus motif; other site 685727006599 AMP binding site [chemical binding]; other site 685727006600 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 685727006601 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 685727006602 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 685727006603 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 685727006604 acyl-activating enzyme (AAE) consensus motif; other site 685727006605 AMP binding site [chemical binding]; other site 685727006606 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 685727006607 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 685727006608 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 685727006609 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 685727006610 Glutamine amidotransferase class-I; Region: GATase; pfam00117 685727006611 glutamine binding [chemical binding]; other site 685727006612 catalytic triad [active] 685727006613 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 685727006614 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 685727006615 chorismate binding enzyme; Region: Chorismate_bind; cl10555 685727006616 Chorismate mutase type II; Region: CM_2; cl00693 685727006617 Secretory lipase; Region: LIP; pfam03583 685727006618 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 685727006619 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 685727006620 Predicted kinase [General function prediction only]; Region: COG0645 685727006621 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 685727006622 active site 685727006623 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 685727006624 FMN binding site [chemical binding]; other site 685727006625 dimer interface [polypeptide binding]; other site 685727006626 Nuclease-related domain; Region: NERD; pfam08378 685727006627 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 685727006628 Ligand Binding Site [chemical binding]; other site 685727006629 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 685727006630 Ligand Binding Site [chemical binding]; other site 685727006631 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 685727006632 Ligand Binding Site [chemical binding]; other site 685727006633 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 685727006634 Ligand Binding Site [chemical binding]; other site 685727006635 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 685727006636 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 685727006637 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 685727006638 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 685727006639 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 685727006640 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685727006641 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 685727006642 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 685727006643 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 685727006644 active site 685727006645 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 685727006646 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 685727006647 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685727006648 Walker A/P-loop; other site 685727006649 ATP binding site [chemical binding]; other site 685727006650 Q-loop/lid; other site 685727006651 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 685727006652 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685727006653 Walker A/P-loop; other site 685727006654 ATP binding site [chemical binding]; other site 685727006655 ABC transporter signature motif; other site 685727006656 Walker B; other site 685727006657 D-loop; other site 685727006658 H-loop/switch region; other site 685727006659 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 685727006660 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 685727006661 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 685727006662 active site 685727006663 DNA binding site [nucleotide binding] 685727006664 Int/Topo IB signature motif; other site 685727006665 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 685727006666 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727006667 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 685727006668 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 685727006669 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 685727006670 CoenzymeA binding site [chemical binding]; other site 685727006671 subunit interaction site [polypeptide binding]; other site 685727006672 PHB binding site; other site 685727006673 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 685727006674 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 685727006675 ABC-ATPase subunit interface; other site 685727006676 dimer interface [polypeptide binding]; other site 685727006677 putative PBP binding regions; other site 685727006678 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 685727006679 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 685727006680 dimer interface [polypeptide binding]; other site 685727006681 putative PBP binding regions; other site 685727006682 ABC-ATPase subunit interface; other site 685727006683 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 685727006684 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 685727006685 Walker A/P-loop; other site 685727006686 ATP binding site [chemical binding]; other site 685727006687 Q-loop/lid; other site 685727006688 ABC transporter signature motif; other site 685727006689 Walker B; other site 685727006690 D-loop; other site 685727006691 H-loop/switch region; other site 685727006692 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 685727006693 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 685727006694 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 685727006695 HTH domain; Region: HTH_11; pfam08279 685727006696 WYL domain; Region: WYL; pfam13280 685727006697 RES domain; Region: RES; pfam08808 685727006698 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 685727006699 Putative esterase; Region: Esterase; pfam00756 685727006700 Predicted transcriptional regulator [Transcription]; Region: COG3682 685727006701 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 685727006702 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 685727006703 DEAD-like helicases superfamily; Region: DEXDc; smart00487 685727006704 ATP binding site [chemical binding]; other site 685727006705 Mg++ binding site [ion binding]; other site 685727006706 motif III; other site 685727006707 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 685727006708 nucleotide binding region [chemical binding]; other site 685727006709 ATP-binding site [chemical binding]; other site 685727006710 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 685727006711 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 685727006712 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 685727006713 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 685727006714 nucleoside/Zn binding site; other site 685727006715 dimer interface [polypeptide binding]; other site 685727006716 catalytic motif [active] 685727006717 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 685727006718 DEAD-like helicases superfamily; Region: DEXDc; smart00487 685727006719 ATP binding site [chemical binding]; other site 685727006720 Mg++ binding site [ion binding]; other site 685727006721 motif III; other site 685727006722 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 685727006723 nucleotide binding region [chemical binding]; other site 685727006724 ATP-binding site [chemical binding]; other site 685727006725 Pirin; Region: Pirin; pfam02678 685727006726 Pirin-related protein [General function prediction only]; Region: COG1741 685727006727 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 685727006728 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 685727006729 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 685727006730 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 685727006731 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 685727006732 phosphate binding site [ion binding]; other site 685727006733 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 685727006734 Domain of unknown function DUF21; Region: DUF21; pfam01595 685727006735 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 685727006736 Transporter associated domain; Region: CorC_HlyC; smart01091 685727006737 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 685727006738 Domain of unknown function DUF21; Region: DUF21; pfam01595 685727006739 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 685727006740 additional locus_tag=REQ_24320 685727006741 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 685727006742 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 685727006743 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 685727006744 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 685727006745 active site 685727006746 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 685727006747 active site 685727006748 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 685727006749 metal ion-dependent adhesion site (MIDAS); other site 685727006750 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 685727006751 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 685727006752 putative active site [active] 685727006753 putative metal binding site [ion binding]; other site 685727006754 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 685727006755 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 685727006756 DNA binding residues [nucleotide binding] 685727006757 dimerization interface [polypeptide binding]; other site 685727006758 Methyltransferase domain; Region: Methyltransf_31; pfam13847 685727006759 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685727006760 S-adenosylmethionine binding site [chemical binding]; other site 685727006761 glycine dehydrogenase; Provisional; Region: PRK05367 685727006762 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 685727006763 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685727006764 tetramer interface [polypeptide binding]; other site 685727006765 catalytic residue [active] 685727006766 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 685727006767 tetramer interface [polypeptide binding]; other site 685727006768 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685727006769 catalytic residue [active] 685727006770 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 685727006771 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 685727006772 DNA binding residues [nucleotide binding] 685727006773 putative dimer interface [polypeptide binding]; other site 685727006774 Bifunctional nuclease; Region: DNase-RNase; pfam02577 685727006775 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 685727006776 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 685727006777 DNA binding residues [nucleotide binding] 685727006778 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 685727006779 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 685727006780 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 685727006781 phosphopeptide binding site; other site 685727006782 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 685727006783 lipoyl attachment site [posttranslational modification]; other site 685727006784 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 685727006785 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 685727006786 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 685727006787 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 685727006788 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 685727006789 Strictosidine synthase; Region: Str_synth; pfam03088 685727006790 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 685727006791 putative active site [active] 685727006792 putative CoA binding site [chemical binding]; other site 685727006793 nudix motif; other site 685727006794 metal binding site [ion binding]; metal-binding site 685727006795 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 685727006796 Protein of unknown function (DUF732); Region: DUF732; pfam05305 685727006797 GTP-binding protein Der; Reviewed; Region: PRK03003 685727006798 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 685727006799 G1 box; other site 685727006800 GTP/Mg2+ binding site [chemical binding]; other site 685727006801 Switch I region; other site 685727006802 G2 box; other site 685727006803 Switch II region; other site 685727006804 G3 box; other site 685727006805 G4 box; other site 685727006806 G5 box; other site 685727006807 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 685727006808 G1 box; other site 685727006809 GTP/Mg2+ binding site [chemical binding]; other site 685727006810 Switch I region; other site 685727006811 G2 box; other site 685727006812 G3 box; other site 685727006813 Switch II region; other site 685727006814 G4 box; other site 685727006815 G5 box; other site 685727006816 cytidylate kinase; Provisional; Region: cmk; PRK00023 685727006817 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 685727006818 CMP-binding site; other site 685727006819 The sites determining sugar specificity; other site 685727006820 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 685727006821 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 685727006822 RNA binding surface [nucleotide binding]; other site 685727006823 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 685727006824 active site 685727006825 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 685727006826 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 685727006827 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 685727006828 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 685727006829 P-loop; other site 685727006830 Magnesium ion binding site [ion binding]; other site 685727006831 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 685727006832 Magnesium ion binding site [ion binding]; other site 685727006833 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 685727006834 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 685727006835 active site 685727006836 Int/Topo IB signature motif; other site 685727006837 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 685727006838 dimer interface [polypeptide binding]; other site 685727006839 active site 685727006840 ADP-ribose binding site [chemical binding]; other site 685727006841 nudix motif; other site 685727006842 metal binding site [ion binding]; metal-binding site 685727006843 CTP synthetase; Validated; Region: pyrG; PRK05380 685727006844 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 685727006845 Catalytic site [active] 685727006846 active site 685727006847 UTP binding site [chemical binding]; other site 685727006848 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 685727006849 active site 685727006850 putative oxyanion hole; other site 685727006851 catalytic triad [active] 685727006852 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 685727006853 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 685727006854 Protein of unknown function DUF115; Region: MAF_flag10; cl17471 685727006855 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 685727006856 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 685727006857 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685727006858 Walker A/P-loop; other site 685727006859 ATP binding site [chemical binding]; other site 685727006860 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 685727006861 ABC transporter signature motif; other site 685727006862 Walker B; other site 685727006863 D-loop; other site 685727006864 H-loop/switch region; other site 685727006865 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 685727006866 ATP-NAD kinase; Region: NAD_kinase; pfam01513 685727006867 hemolysin TlyA family protein; Region: tly; TIGR00478 685727006868 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685727006869 S-adenosylmethionine binding site [chemical binding]; other site 685727006870 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 685727006871 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685727006872 active site 685727006873 motif I; other site 685727006874 motif II; other site 685727006875 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 685727006876 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 685727006877 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 685727006878 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 685727006879 active site 685727006880 HIGH motif; other site 685727006881 dimer interface [polypeptide binding]; other site 685727006882 KMSKS motif; other site 685727006883 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 685727006884 RNA binding surface [nucleotide binding]; other site 685727006885 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 685727006886 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 685727006887 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 685727006888 Walker A/P-loop; other site 685727006889 ATP binding site [chemical binding]; other site 685727006890 Q-loop/lid; other site 685727006891 ABC transporter signature motif; other site 685727006892 Walker B; other site 685727006893 D-loop; other site 685727006894 H-loop/switch region; other site 685727006895 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 685727006896 ABC-2 type transporter; Region: ABC2_membrane; cl17235 685727006897 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727006898 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727006899 acyl-CoA synthetase; Validated; Region: PRK07868 685727006900 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 685727006901 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 685727006902 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 685727006903 acyl-activating enzyme (AAE) consensus motif; other site 685727006904 active site 685727006905 CoA binding site [chemical binding]; other site 685727006906 AMP binding site [chemical binding]; other site 685727006907 argininosuccinate lyase; Provisional; Region: PRK00855 685727006908 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 685727006909 active sites [active] 685727006910 tetramer interface [polypeptide binding]; other site 685727006911 argininosuccinate synthase; Provisional; Region: PRK13820 685727006912 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 685727006913 ANP binding site [chemical binding]; other site 685727006914 Substrate Binding Site II [chemical binding]; other site 685727006915 Substrate Binding Site I [chemical binding]; other site 685727006916 arginine repressor; Provisional; Region: PRK03341 685727006917 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 685727006918 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 685727006919 ornithine carbamoyltransferase; Provisional; Region: PRK00779 685727006920 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 685727006921 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 685727006922 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 685727006923 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 685727006924 inhibitor-cofactor binding pocket; inhibition site 685727006925 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685727006926 catalytic residue [active] 685727006927 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 685727006928 feedback inhibition sensing region; other site 685727006929 homohexameric interface [polypeptide binding]; other site 685727006930 nucleotide binding site [chemical binding]; other site 685727006931 N-acetyl-L-glutamate binding site [chemical binding]; other site 685727006932 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 685727006933 heterotetramer interface [polypeptide binding]; other site 685727006934 active site pocket [active] 685727006935 cleavage site 685727006936 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 685727006937 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 685727006938 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 685727006939 active site 685727006940 catalytic triad [active] 685727006941 oxyanion hole [active] 685727006942 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 685727006943 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 685727006944 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 685727006945 putative tRNA-binding site [nucleotide binding]; other site 685727006946 B3/4 domain; Region: B3_4; pfam03483 685727006947 tRNA synthetase B5 domain; Region: B5; smart00874 685727006948 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 685727006949 dimer interface [polypeptide binding]; other site 685727006950 motif 1; other site 685727006951 motif 3; other site 685727006952 motif 2; other site 685727006953 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 685727006954 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 685727006955 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 685727006956 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 685727006957 dimer interface [polypeptide binding]; other site 685727006958 motif 1; other site 685727006959 active site 685727006960 motif 2; other site 685727006961 motif 3; other site 685727006962 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 685727006963 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 685727006964 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 685727006965 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 685727006966 23S rRNA binding site [nucleotide binding]; other site 685727006967 L21 binding site [polypeptide binding]; other site 685727006968 L13 binding site [polypeptide binding]; other site 685727006969 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 685727006970 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 685727006971 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 685727006972 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 685727006973 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 685727006974 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 685727006975 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 685727006976 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 685727006977 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 685727006978 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 685727006979 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 685727006980 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685727006981 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 685727006982 active site 685727006983 motif I; other site 685727006984 motif II; other site 685727006985 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 685727006986 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 685727006987 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 685727006988 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 685727006989 Predicted membrane protein [Function unknown]; Region: COG2259 685727006990 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 685727006991 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 685727006992 NAD(P) binding site [chemical binding]; other site 685727006993 catalytic residues [active] 685727006994 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 685727006995 Part of AAA domain; Region: AAA_19; pfam13245 685727006996 Family description; Region: UvrD_C_2; pfam13538 685727006997 excinuclease ABC subunit B; Provisional; Region: PRK05298 685727006998 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 685727006999 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 685727007000 nucleotide binding region [chemical binding]; other site 685727007001 ATP-binding site [chemical binding]; other site 685727007002 Ultra-violet resistance protein B; Region: UvrB; pfam12344 685727007003 UvrB/uvrC motif; Region: UVR; pfam02151 685727007004 Protein of unknown function (DUF402); Region: DUF402; cl00979 685727007005 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 685727007006 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 685727007007 ATP-binding [chemical binding]; other site 685727007008 CoA-binding site [chemical binding]; other site 685727007009 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 685727007010 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 685727007011 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 685727007012 RNA binding site [nucleotide binding]; other site 685727007013 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 685727007014 RNA binding site [nucleotide binding]; other site 685727007015 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 685727007016 RNA binding site [nucleotide binding]; other site 685727007017 S1 RNA binding domain; Region: S1; pfam00575 685727007018 RNA binding site [nucleotide binding]; other site 685727007019 Thiopurine S-methyltransferase (TPMT); Region: TPMT; pfam05724 685727007020 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685727007021 S-adenosylmethionine binding site [chemical binding]; other site 685727007022 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 685727007023 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 685727007024 Walker A/P-loop; other site 685727007025 ATP binding site [chemical binding]; other site 685727007026 Q-loop/lid; other site 685727007027 ABC transporter signature motif; other site 685727007028 Walker B; other site 685727007029 D-loop; other site 685727007030 H-loop/switch region; other site 685727007031 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 685727007032 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685727007033 dimer interface [polypeptide binding]; other site 685727007034 conserved gate region; other site 685727007035 putative PBP binding loops; other site 685727007036 ABC-ATPase subunit interface; other site 685727007037 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 685727007038 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 685727007039 substrate binding pocket [chemical binding]; other site 685727007040 membrane-bound complex binding site; other site 685727007041 hinge residues; other site 685727007042 tartrate dehydrogenase; Provisional; Region: PRK08194 685727007043 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 685727007044 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 685727007045 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 685727007046 catalytic residues [active] 685727007047 DNA polymerase I; Provisional; Region: PRK05755 685727007048 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 685727007049 active site 685727007050 metal binding site 1 [ion binding]; metal-binding site 685727007051 putative 5' ssDNA interaction site; other site 685727007052 metal binding site 3; metal-binding site 685727007053 metal binding site 2 [ion binding]; metal-binding site 685727007054 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 685727007055 putative DNA binding site [nucleotide binding]; other site 685727007056 putative metal binding site [ion binding]; other site 685727007057 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 685727007058 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 685727007059 active site 685727007060 DNA binding site [nucleotide binding] 685727007061 catalytic site [active] 685727007062 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 685727007063 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685727007064 active site 685727007065 phosphorylation site [posttranslational modification] 685727007066 intermolecular recognition site; other site 685727007067 dimerization interface [polypeptide binding]; other site 685727007068 ANTAR domain; Region: ANTAR; pfam03861 685727007069 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 685727007070 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 685727007071 DUF35 OB-fold domain; Region: DUF35; pfam01796 685727007072 lipid-transfer protein; Provisional; Region: PRK06059 685727007073 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 685727007074 active site 685727007075 Isochorismatase family; Region: Isochorismatase; pfam00857 685727007076 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 685727007077 catalytic triad [active] 685727007078 conserved cis-peptide bond; other site 685727007079 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 685727007080 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 685727007081 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 685727007082 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 685727007083 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 685727007084 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 685727007085 active site 685727007086 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 685727007087 catalytic triad [active] 685727007088 dimer interface [polypeptide binding]; other site 685727007089 pyruvate kinase; Provisional; Region: PRK06247 685727007090 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 685727007091 domain interfaces; other site 685727007092 active site 685727007093 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 685727007094 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 685727007095 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 685727007096 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 685727007097 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 685727007098 active site 685727007099 dimer interface [polypeptide binding]; other site 685727007100 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 685727007101 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 685727007102 active site 685727007103 FMN binding site [chemical binding]; other site 685727007104 substrate binding site [chemical binding]; other site 685727007105 3Fe-4S cluster binding site [ion binding]; other site 685727007106 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 685727007107 domain interface; other site 685727007108 TM2 domain; Region: TM2; pfam05154 685727007109 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 685727007110 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 685727007111 substrate binding site [chemical binding]; other site 685727007112 active site 685727007113 catalytic residues [active] 685727007114 heterodimer interface [polypeptide binding]; other site 685727007115 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 685727007116 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 685727007117 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685727007118 catalytic residue [active] 685727007119 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 685727007120 active site 685727007121 ribulose/triose binding site [chemical binding]; other site 685727007122 phosphate binding site [ion binding]; other site 685727007123 substrate (anthranilate) binding pocket [chemical binding]; other site 685727007124 product (indole) binding pocket [chemical binding]; other site 685727007125 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; cl17850 685727007126 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 685727007127 anthranilate synthase component I; Provisional; Region: PRK13571 685727007128 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 685727007129 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 685727007130 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 685727007131 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 685727007132 catalytic triad [active] 685727007133 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 685727007134 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 685727007135 putative active site [active] 685727007136 metal binding site [ion binding]; metal-binding site 685727007137 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 685727007138 MarR family; Region: MarR_2; cl17246 685727007139 Cupin domain; Region: Cupin_2; cl17218 685727007140 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 685727007141 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685727007142 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 685727007143 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 685727007144 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 685727007145 classical (c) SDRs; Region: SDR_c; cd05233 685727007146 NAD(P) binding site [chemical binding]; other site 685727007147 active site 685727007148 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 685727007149 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; pfam10069 685727007150 EAL domain; Region: EAL; pfam00563 685727007151 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; pfam10069 685727007152 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 685727007153 hydrophobic ligand binding site; other site 685727007154 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 685727007155 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 685727007156 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 685727007157 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727007158 NAD(P) binding site [chemical binding]; other site 685727007159 active site 685727007160 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 685727007161 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 685727007162 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 685727007163 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 685727007164 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 685727007165 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 685727007166 putative active site [active] 685727007167 classical (c) SDRs; Region: SDR_c; cd05233 685727007168 NAD(P) binding site [chemical binding]; other site 685727007169 active site 685727007170 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 685727007171 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 685727007172 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 685727007173 active site 685727007174 HIGH motif; other site 685727007175 nucleotide binding site [chemical binding]; other site 685727007176 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 685727007177 dimer interface [polypeptide binding]; other site 685727007178 active site 685727007179 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 685727007180 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 685727007181 additional locus_tag=REQ_25650 685727007182 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727007183 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727007184 short chain dehydrogenase; Provisional; Region: PRK06500 685727007185 classical (c) SDRs; Region: SDR_c; cd05233 685727007186 NAD(P) binding site [chemical binding]; other site 685727007187 active site 685727007188 Major Facilitator Superfamily; Region: MFS_1; pfam07690 685727007189 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727007190 putative substrate translocation pore; other site 685727007191 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727007192 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727007193 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 685727007194 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 685727007195 active site 685727007196 catalytic tetrad [active] 685727007197 Predicted transcriptional regulators [Transcription]; Region: COG1733 685727007198 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 685727007199 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 685727007200 CGNR zinc finger; Region: zf-CGNR; pfam11706 685727007201 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 685727007202 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727007203 NADH(P)-binding; Region: NAD_binding_10; pfam13460 685727007204 NAD(P) binding site [chemical binding]; other site 685727007205 active site 685727007206 AAA domain; Region: AAA_22; pfam13401 685727007207 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 685727007208 Protein of unknown function, DUF488; Region: DUF488; pfam04343 685727007209 Epoxide hydrolase N terminus; Region: EHN; pfam06441 685727007210 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 685727007211 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 685727007212 putative hydrophobic ligand binding site [chemical binding]; other site 685727007213 Gas vesicle protein; Region: Gas_vesicle; cl02954 685727007214 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 685727007215 Gas vesicle protein G; Region: GvpG; pfam05120 685727007216 Gas vesicle synthesis protein GvpO; Region: GvpO; pfam05800 685727007217 Gas vesicle protein; Region: Gas_vesicle; pfam00741 685727007218 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 685727007219 Gas vesicle protein K; Region: GvpK; pfam05121 685727007221 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727007222 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 685727007223 NAD(P) binding site [chemical binding]; other site 685727007224 active site 685727007225 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 685727007226 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 685727007227 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 685727007228 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 685727007229 active site 685727007230 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 685727007231 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685727007232 active site 685727007233 motif I; other site 685727007234 motif II; other site 685727007235 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 685727007236 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 685727007237 putative active site [active] 685727007238 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 685727007239 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 685727007240 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 685727007241 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 685727007242 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 685727007243 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 685727007244 DNA binding residues [nucleotide binding] 685727007245 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 685727007246 anti sigma factor interaction site; other site 685727007247 regulatory phosphorylation site [posttranslational modification]; other site 685727007248 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 685727007249 GAF domain; Region: GAF; pfam01590 685727007250 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 685727007251 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 685727007252 Competence-damaged protein; Region: CinA; pfam02464 685727007253 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 685727007254 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 685727007255 NAD binding site [chemical binding]; other site 685727007256 catalytic Zn binding site [ion binding]; other site 685727007257 structural Zn binding site [ion binding]; other site 685727007258 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 685727007259 putative methyltransferase; Provisional; Region: PRK14967 685727007260 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685727007261 S-adenosylmethionine binding site [chemical binding]; other site 685727007262 Methyltransferase domain; Region: Methyltransf_23; pfam13489 685727007263 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685727007264 S-adenosylmethionine binding site [chemical binding]; other site 685727007265 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 685727007266 active site 685727007267 NTP binding site [chemical binding]; other site 685727007268 metal binding triad [ion binding]; metal-binding site 685727007269 antibiotic binding site [chemical binding]; other site 685727007270 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 685727007271 hydrophobic ligand binding site; other site 685727007272 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727007273 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727007274 FAD binding domain; Region: FAD_binding_3; pfam01494 685727007275 hypothetical protein; Provisional; Region: PRK07236 685727007276 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 685727007277 Cupin domain; Region: Cupin_2; pfam07883 685727007278 MarR family; Region: MarR_2; pfam12802 685727007279 ChaB; Region: ChaB; pfam06150 685727007280 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 685727007281 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 685727007282 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 685727007283 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 685727007284 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 685727007285 dimanganese center [ion binding]; other site 685727007286 Hemerythrin-like domain; Region: Hr-like; cd12108 685727007287 Fe binding site [ion binding]; other site 685727007288 oxidoreductase; Provisional; Region: PRK06128 685727007289 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727007290 NAD(P) binding site [chemical binding]; other site 685727007291 active site 685727007292 Cytochrome P450; Region: p450; cl12078 685727007293 SAP domain; Region: SAP; cl02640 685727007294 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 685727007295 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 685727007296 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 685727007297 iron-sulfur cluster [ion binding]; other site 685727007298 [2Fe-2S] cluster binding site [ion binding]; other site 685727007299 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 685727007300 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 685727007301 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 685727007302 catalytic residue [active] 685727007303 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 685727007304 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 685727007305 hydrophobic ligand binding site; other site 685727007306 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 685727007307 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 685727007308 NAD binding site [chemical binding]; other site 685727007309 catalytic Zn binding site [ion binding]; other site 685727007310 structural Zn binding site [ion binding]; other site 685727007311 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 685727007312 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 685727007313 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727007314 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727007315 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 685727007316 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 685727007317 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 685727007318 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 685727007319 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 685727007320 active site 685727007321 metal binding site [ion binding]; metal-binding site 685727007322 homotetramer interface [polypeptide binding]; other site 685727007323 oxidoreductase; Provisional; Region: PRK12743 685727007324 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727007325 NAD(P) binding site [chemical binding]; other site 685727007326 active site 685727007327 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 685727007328 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 685727007329 AlkA N-terminal domain; Region: AlkA_N; cl05528 685727007330 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 685727007331 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 685727007332 MarR family; Region: MarR_2; pfam12802 685727007333 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 685727007334 Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358 685727007335 putative ligand binding site [chemical binding]; other site 685727007336 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 685727007337 acylamide amidohydrolase; Provisional; Region: amiE; PRK13286 685727007338 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 685727007339 multimer interface [polypeptide binding]; other site 685727007340 active site 685727007341 catalytic triad [active] 685727007342 dimer interface [polypeptide binding]; other site 685727007343 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 685727007344 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685727007345 Walker A motif; other site 685727007346 ATP binding site [chemical binding]; other site 685727007347 Walker B motif; other site 685727007348 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 685727007349 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 685727007350 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 685727007351 putative dimer interface [polypeptide binding]; other site 685727007352 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 685727007353 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 685727007354 SnoaL-like domain; Region: SnoaL_4; pfam13577 685727007355 TetR family transcriptional regulator; Provisional; Region: PRK14996 685727007356 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727007357 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 685727007358 Beta-lactamase; Region: Beta-lactamase; pfam00144 685727007359 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 685727007360 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 685727007361 Coenzyme A binding pocket [chemical binding]; other site 685727007362 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 685727007363 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 685727007364 active site 685727007365 DNA binding site [nucleotide binding] 685727007366 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 685727007367 DNA binding site [nucleotide binding] 685727007368 ANTAR domain; Region: ANTAR; pfam03861 685727007369 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727007370 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727007371 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 685727007372 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 685727007373 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 685727007374 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 685727007375 substrate binding site [chemical binding]; other site 685727007376 glutamase interaction surface [polypeptide binding]; other site 685727007377 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 685727007378 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 685727007379 active site 685727007380 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 685727007381 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 685727007382 catalytic residues [active] 685727007383 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 685727007384 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 685727007385 putative active site [active] 685727007386 oxyanion strand; other site 685727007387 catalytic triad [active] 685727007388 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727007389 putative substrate translocation pore; other site 685727007390 Major Facilitator Superfamily; Region: MFS_1; pfam07690 685727007391 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 685727007392 putative active site pocket [active] 685727007393 4-fold oligomerization interface [polypeptide binding]; other site 685727007394 metal binding residues [ion binding]; metal-binding site 685727007395 3-fold/trimer interface [polypeptide binding]; other site 685727007396 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 685727007397 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 685727007398 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685727007399 homodimer interface [polypeptide binding]; other site 685727007400 catalytic residue [active] 685727007401 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 685727007402 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 685727007403 NAD binding site [chemical binding]; other site 685727007404 dimerization interface [polypeptide binding]; other site 685727007405 product binding site; other site 685727007406 substrate binding site [chemical binding]; other site 685727007407 zinc binding site [ion binding]; other site 685727007408 catalytic residues [active] 685727007409 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 685727007410 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 685727007411 NAD(P) binding site [chemical binding]; other site 685727007412 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 685727007413 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 685727007414 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 685727007415 LysE type translocator; Region: LysE; cl00565 685727007416 Low affinity iron permease; Region: Iron_permease; cl12096 685727007417 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 685727007418 hydroperoxidase II; Provisional; Region: katE; PRK11249 685727007419 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 685727007420 heme binding pocket [chemical binding]; other site 685727007421 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 685727007422 domain interactions; other site 685727007423 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 685727007424 active site 685727007425 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 685727007426 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 685727007427 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 685727007428 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 685727007429 putative ADP-binding pocket [chemical binding]; other site 685727007430 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 685727007431 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 685727007432 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 685727007433 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 685727007434 DNA binding residues [nucleotide binding] 685727007435 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 685727007436 Walker A motif; other site 685727007437 ATP binding site [chemical binding]; other site 685727007438 Walker B motif; other site 685727007439 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 685727007440 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 685727007441 DNA binding residues [nucleotide binding] 685727007442 dimerization interface [polypeptide binding]; other site 685727007443 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 685727007444 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 685727007445 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 685727007446 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 685727007447 dimerization interface [polypeptide binding]; other site 685727007448 active site 685727007449 L-aspartate oxidase; Provisional; Region: PRK07804 685727007450 L-aspartate oxidase; Provisional; Region: PRK06175 685727007451 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 685727007452 quinolinate synthetase; Provisional; Region: PRK09375 685727007453 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 685727007454 nudix motif; other site 685727007455 additional locus_tag=REQ_27000 685727007456 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 685727007457 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727007458 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 685727007459 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 685727007460 biotin synthase; Validated; Region: PRK06256 685727007461 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 685727007462 FeS/SAM binding site; other site 685727007463 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 685727007464 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727007465 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 685727007466 Secretory lipase; Region: LIP; pfam03583 685727007467 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 685727007468 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 685727007469 Uncharacterized conserved protein [Function unknown]; Region: COG1656 685727007470 Protein of unknown function DUF82; Region: DUF82; pfam01927 685727007471 ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351 685727007472 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 685727007473 metal binding site [ion binding]; metal-binding site 685727007474 peptide synthase; Provisional; Region: PRK12316 685727007475 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 685727007476 acyl-activating enzyme (AAE) consensus motif; other site 685727007477 AMP binding site [chemical binding]; other site 685727007478 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 685727007479 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 685727007480 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 685727007481 acyl-activating enzyme (AAE) consensus motif; other site 685727007482 AMP binding site [chemical binding]; other site 685727007483 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 685727007484 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 685727007485 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 685727007486 acyl-activating enzyme (AAE) consensus motif; other site 685727007487 AMP binding site [chemical binding]; other site 685727007488 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 685727007489 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 685727007490 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 685727007491 acyl-activating enzyme (AAE) consensus motif; other site 685727007492 AMP binding site [chemical binding]; other site 685727007493 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 685727007494 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 685727007495 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 685727007496 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 685727007497 catalytic loop [active] 685727007498 iron binding site [ion binding]; other site 685727007499 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 685727007500 L-aspartate oxidase; Provisional; Region: PRK06175 685727007501 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 685727007502 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 685727007503 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 685727007504 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 685727007505 peroxiredoxin; Region: AhpC; TIGR03137 685727007506 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 685727007507 dimer interface [polypeptide binding]; other site 685727007508 decamer (pentamer of dimers) interface [polypeptide binding]; other site 685727007509 catalytic triad [active] 685727007510 peroxidatic and resolving cysteines [active] 685727007511 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 685727007512 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 685727007513 catalytic residue [active] 685727007514 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 685727007515 catalytic residues [active] 685727007516 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 685727007517 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 685727007518 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 685727007519 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 685727007520 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 685727007521 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 685727007522 catalytic residue [active] 685727007523 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 685727007524 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 685727007525 inhibitor-cofactor binding pocket; inhibition site 685727007526 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685727007527 catalytic residue [active] 685727007528 Acyltransferase family; Region: Acyl_transf_3; pfam01757 685727007529 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 685727007530 Cytochrome P450; Region: p450; cl12078 685727007531 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 685727007532 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 685727007533 Coenzyme A binding pocket [chemical binding]; other site 685727007534 Domain of unknown function (DUF222); Region: DUF222; pfam02720 685727007535 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 685727007536 active site 685727007537 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 685727007538 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 685727007539 Gar1/Naf1 RNA binding region; Region: Gar1; cl01285 685727007540 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 685727007541 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 685727007542 NAD binding site [chemical binding]; other site 685727007543 substrate binding site [chemical binding]; other site 685727007544 catalytic Zn binding site [ion binding]; other site 685727007545 structural Zn binding site [ion binding]; other site 685727007546 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 685727007547 Cl- selectivity filter; other site 685727007548 Cl- binding residues [ion binding]; other site 685727007549 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 685727007550 pore gating glutamate residue; other site 685727007551 dimer interface [polypeptide binding]; other site 685727007552 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 685727007553 Nitrogen regulatory protein P-II; Region: P-II; cl00412 685727007554 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 685727007555 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 685727007556 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 685727007557 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 685727007558 active site 685727007559 catalytic site [active] 685727007560 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 685727007561 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 685727007562 active site 685727007563 catalytic site [active] 685727007564 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 685727007565 classical (c) SDRs; Region: SDR_c; cd05233 685727007566 NAD(P) binding site [chemical binding]; other site 685727007567 active site 685727007568 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 685727007569 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 685727007570 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 685727007571 catalytic site [active] 685727007572 active site 685727007573 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 685727007574 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 685727007575 active site 685727007576 putative catalytic site [active] 685727007577 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 685727007578 active site 685727007579 catalytic site [active] 685727007580 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 685727007581 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727007582 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727007583 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727007584 threonine dehydratase; Validated; Region: PRK08639 685727007585 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 685727007586 tetramer interface [polypeptide binding]; other site 685727007587 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685727007588 catalytic residue [active] 685727007589 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 685727007590 pyruvate dehydrogenase; Provisional; Region: PRK06546 685727007591 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 685727007592 PYR/PP interface [polypeptide binding]; other site 685727007593 dimer interface [polypeptide binding]; other site 685727007594 tetramer interface [polypeptide binding]; other site 685727007595 TPP binding site [chemical binding]; other site 685727007596 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 685727007597 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 685727007598 TPP-binding site [chemical binding]; other site 685727007599 Domain of unknown function (DUF385); Region: DUF385; pfam04075 685727007600 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 685727007601 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 685727007602 active site 685727007603 PHP Thumb interface [polypeptide binding]; other site 685727007604 metal binding site [ion binding]; metal-binding site 685727007605 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 685727007606 generic binding surface II; other site 685727007607 generic binding surface I; other site 685727007608 Predicted permeases [General function prediction only]; Region: RarD; COG2962 685727007609 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 685727007610 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 685727007611 substrate binding pocket [chemical binding]; other site 685727007612 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 685727007613 Chorismate mutase type II; Region: CM_2; cl00693 685727007614 chorismate mutase; Provisional; Region: PRK09269 685727007615 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 685727007616 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 685727007617 active site 685727007618 lipoprotein signal peptidase; Provisional; Region: PRK14764 685727007619 DNA polymerase IV; Provisional; Region: PRK03348 685727007620 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 685727007621 active site 685727007622 DNA binding site [nucleotide binding] 685727007623 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 685727007624 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 685727007625 HIGH motif; other site 685727007626 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 685727007627 active site 685727007628 KMSKS motif; other site 685727007629 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 685727007630 tRNA binding surface [nucleotide binding]; other site 685727007631 anticodon binding site; other site 685727007632 DivIVA domain; Region: DivI1A_domain; TIGR03544 685727007633 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 685727007634 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 685727007635 YGGT family; Region: YGGT; cl00508 685727007636 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 685727007637 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 685727007638 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 685727007639 catalytic residue [active] 685727007640 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 685727007641 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 685727007642 cell division protein FtsZ; Validated; Region: PRK09330 685727007643 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 685727007644 nucleotide binding site [chemical binding]; other site 685727007645 SulA interaction site; other site 685727007646 cell division protein FtsQ; Provisional; Region: PRK05529 685727007647 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 685727007648 Cell division protein FtsQ; Region: FtsQ; pfam03799 685727007649 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 685727007650 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 685727007651 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 685727007652 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 685727007653 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 685727007654 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 685727007655 active site 685727007656 homodimer interface [polypeptide binding]; other site 685727007657 cell division protein FtsW; Region: ftsW; TIGR02614 685727007658 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 685727007659 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 685727007660 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 685727007661 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 685727007662 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 685727007663 Mg++ binding site [ion binding]; other site 685727007664 putative catalytic motif [active] 685727007665 putative substrate binding site [chemical binding]; other site 685727007666 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 685727007667 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 685727007668 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 685727007669 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 685727007670 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 685727007671 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 685727007672 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 685727007673 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 685727007674 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 685727007675 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 685727007676 MraW methylase family; Region: Methyltransf_5; cl17771 685727007677 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 685727007678 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 685727007679 MraZ protein; Region: MraZ; pfam02381 685727007680 MraZ protein; Region: MraZ; pfam02381 685727007681 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 685727007682 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 685727007683 phytoene desaturase; Region: crtI_fam; TIGR02734 685727007684 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 685727007685 Protein of unknown function (DUF422); Region: DUF422; cl00991 685727007686 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 685727007687 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 685727007688 FAD binding site [chemical binding]; other site 685727007689 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 685727007690 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 685727007691 substrate binding pocket [chemical binding]; other site 685727007692 chain length determination region; other site 685727007693 substrate-Mg2+ binding site; other site 685727007694 catalytic residues [active] 685727007695 aspartate-rich region 1; other site 685727007696 active site lid residues [active] 685727007697 aspartate-rich region 2; other site 685727007698 phytoene desaturase; Region: crtI_fam; TIGR02734 685727007699 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 685727007700 hydroxyglutarate oxidase; Provisional; Region: PRK11728 685727007701 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 685727007702 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 685727007703 active site lid residues [active] 685727007704 substrate binding pocket [chemical binding]; other site 685727007705 catalytic residues [active] 685727007706 substrate-Mg2+ binding site; other site 685727007707 aspartate-rich region 1; other site 685727007708 aspartate-rich region 2; other site 685727007709 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 685727007710 Catalytic domain of Protein Kinases; Region: PKc; cd00180 685727007711 active site 685727007712 ATP binding site [chemical binding]; other site 685727007713 substrate binding site [chemical binding]; other site 685727007714 activation loop (A-loop); other site 685727007715 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 685727007716 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 685727007717 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 685727007718 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 685727007719 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 685727007720 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 685727007721 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 685727007722 putative active site [active] 685727007723 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 685727007724 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 685727007725 putative acyl-acceptor binding pocket; other site 685727007726 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 685727007727 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 685727007728 nucleotide binding site [chemical binding]; other site 685727007729 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 685727007730 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 685727007731 DTAP/Switch II; other site 685727007732 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 685727007733 putative hydrophobic ligand binding site [chemical binding]; other site 685727007734 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 685727007735 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 685727007736 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 685727007737 acyl-activating enzyme (AAE) consensus motif; other site 685727007738 putative AMP binding site [chemical binding]; other site 685727007739 putative active site [active] 685727007740 putative CoA binding site [chemical binding]; other site 685727007741 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 685727007742 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 685727007743 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 685727007744 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 685727007745 NlpC/P60 family; Region: NLPC_P60; pfam00877 685727007746 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 685727007747 NlpC/P60 family; Region: NLPC_P60; pfam00877 685727007748 hypothetical protein; Validated; Region: PRK07883 685727007749 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 685727007750 active site 685727007751 catalytic site [active] 685727007752 substrate binding site [chemical binding]; other site 685727007753 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 685727007754 GIY-YIG motif/motif A; other site 685727007755 active site 685727007756 catalytic site [active] 685727007757 putative DNA binding site [nucleotide binding]; other site 685727007758 metal binding site [ion binding]; metal-binding site 685727007759 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 685727007760 AsnC family; Region: AsnC_trans_reg; pfam01037 685727007761 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 685727007762 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 685727007763 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 685727007764 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 685727007765 Subunit I/III interface [polypeptide binding]; other site 685727007766 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 685727007767 Cytochrome c; Region: Cytochrom_C; pfam00034 685727007768 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 685727007769 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 685727007770 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 685727007771 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 685727007772 iron-sulfur cluster [ion binding]; other site 685727007773 [2Fe-2S] cluster binding site [ion binding]; other site 685727007774 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 685727007775 heme bH binding site [chemical binding]; other site 685727007776 intrachain domain interface; other site 685727007777 heme bL binding site [chemical binding]; other site 685727007778 interchain domain interface [polypeptide binding]; other site 685727007779 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 685727007780 Qo binding site; other site 685727007781 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 685727007782 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 685727007783 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 685727007784 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 685727007785 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 685727007786 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 685727007787 dimer interface [polypeptide binding]; other site 685727007788 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 685727007789 active site 685727007790 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 685727007791 Ligand Binding Site [chemical binding]; other site 685727007792 Molecular Tunnel; other site 685727007793 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 685727007794 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 685727007795 substrate binding site [chemical binding]; other site 685727007796 ATP binding site [chemical binding]; other site 685727007797 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 685727007798 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 685727007799 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 685727007800 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 685727007801 homotrimer interface [polypeptide binding]; other site 685727007802 Walker A motif; other site 685727007803 GTP binding site [chemical binding]; other site 685727007804 Walker B motif; other site 685727007805 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 685727007806 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 685727007807 putative dimer interface [polypeptide binding]; other site 685727007808 active site pocket [active] 685727007809 putative cataytic base [active] 685727007810 cobalamin synthase; Reviewed; Region: cobS; PRK00235 685727007811 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 685727007812 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 685727007813 homodimer interface [polypeptide binding]; other site 685727007814 substrate-cofactor binding pocket; other site 685727007815 catalytic residue [active] 685727007816 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 685727007817 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 685727007818 multifunctional aminopeptidase A; Provisional; Region: PRK00913 685727007819 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 685727007820 interface (dimer of trimers) [polypeptide binding]; other site 685727007821 Substrate-binding/catalytic site; other site 685727007822 Zn-binding sites [ion binding]; other site 685727007823 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 685727007824 E3 interaction surface; other site 685727007825 lipoyl attachment site [posttranslational modification]; other site 685727007826 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 685727007827 E3 interaction surface; other site 685727007828 lipoyl attachment site [posttranslational modification]; other site 685727007829 e3 binding domain; Region: E3_binding; pfam02817 685727007830 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 685727007831 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 685727007832 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727007833 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 685727007834 NAD(P) binding site [chemical binding]; other site 685727007835 active site 685727007836 lipoate-protein ligase B; Provisional; Region: PRK14345 685727007837 lipoyl synthase; Provisional; Region: PRK05481 685727007838 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 685727007839 FeS/SAM binding site; other site 685727007840 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 685727007841 RDD family; Region: RDD; pfam06271 685727007842 glutamine synthetase, type I; Region: GlnA; TIGR00653 685727007843 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 685727007844 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 685727007845 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 685727007846 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 685727007847 dimer interface [polypeptide binding]; other site 685727007848 active site 685727007849 CoA binding pocket [chemical binding]; other site 685727007850 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 685727007851 NlpC/P60 family; Region: NLPC_P60; pfam00877 685727007852 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 685727007853 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 685727007854 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 685727007855 substrate binding site [chemical binding]; other site 685727007856 multimerization interface [polypeptide binding]; other site 685727007857 ATP binding site [chemical binding]; other site 685727007858 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 685727007859 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 685727007860 active site residue [active] 685727007861 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 685727007862 active site residue [active] 685727007863 Transcriptional regulators [Transcription]; Region: GntR; COG1802 685727007864 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 685727007865 DNA-binding site [nucleotide binding]; DNA binding site 685727007866 FCD domain; Region: FCD; pfam07729 685727007867 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 685727007868 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 685727007869 intersubunit interface [polypeptide binding]; other site 685727007870 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 685727007871 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 685727007872 ABC-ATPase subunit interface; other site 685727007873 dimer interface [polypeptide binding]; other site 685727007874 putative PBP binding regions; other site 685727007875 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 685727007876 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685727007877 Walker A/P-loop; other site 685727007878 ATP binding site [chemical binding]; other site 685727007879 Q-loop/lid; other site 685727007880 ABC transporter signature motif; other site 685727007881 Walker B; other site 685727007882 D-loop; other site 685727007883 H-loop/switch region; other site 685727007884 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 685727007885 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 685727007886 metal binding triad; other site 685727007887 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 685727007888 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 685727007889 metal binding triad; other site 685727007890 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 685727007891 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 685727007892 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 685727007893 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 685727007894 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 685727007895 TAP-like protein; Region: Abhydrolase_4; pfam08386 685727007896 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 685727007897 oligomerization interface [polypeptide binding]; other site 685727007898 active site 685727007899 metal binding site [ion binding]; metal-binding site 685727007900 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 685727007901 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 685727007902 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 685727007903 TAP-like protein; Region: Abhydrolase_4; pfam08386 685727007904 CHAD domain; Region: CHAD; pfam05235 685727007905 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 685727007906 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 685727007907 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 685727007908 transmembrane helices; other site 685727007909 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 685727007910 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 685727007911 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 685727007912 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 685727007913 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 685727007914 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 685727007915 RNA/DNA hybrid binding site [nucleotide binding]; other site 685727007916 active site 685727007917 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 685727007918 catalytic core [active] 685727007919 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 685727007920 Putative zinc ribbon domain; Region: DUF164; pfam02591 685727007921 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 685727007922 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 685727007923 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 685727007924 hypothetical protein; Provisional; Region: PRK07908 685727007925 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 685727007926 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685727007927 homodimer interface [polypeptide binding]; other site 685727007928 catalytic residue [active] 685727007929 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 685727007930 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685727007931 motif II; other site 685727007932 Low molecular weight phosphatase family; Region: LMWPc; cd00115 685727007933 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 685727007934 active site 685727007935 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 685727007936 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 685727007937 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 685727007938 spermidine synthase; Provisional; Region: PRK03612 685727007939 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685727007940 S-adenosylmethionine binding site [chemical binding]; other site 685727007941 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 685727007942 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 685727007943 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 685727007944 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 685727007945 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 685727007946 active site 685727007947 catalytic residues [active] 685727007948 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 685727007949 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 685727007950 dimer interface [polypeptide binding]; other site 685727007951 catalytic triad [active] 685727007952 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 685727007953 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 685727007954 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 685727007955 dimer interface [polypeptide binding]; other site 685727007956 TPP-binding site [chemical binding]; other site 685727007957 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 685727007958 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 685727007959 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 685727007960 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 685727007961 acyl carrier protein; Provisional; Region: acpP; PRK00982 685727007962 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 685727007963 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 685727007964 dimer interface [polypeptide binding]; other site 685727007965 active site 685727007966 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 685727007967 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 685727007968 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 685727007969 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 685727007970 Beta-lactamase; Region: Beta-lactamase; pfam00144 685727007971 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 685727007972 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 685727007973 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 685727007974 NAD binding site [chemical binding]; other site 685727007975 catalytic Zn binding site [ion binding]; other site 685727007976 substrate binding site [chemical binding]; other site 685727007977 structural Zn binding site [ion binding]; other site 685727007978 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 685727007979 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 685727007980 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 685727007981 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 685727007982 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 685727007983 active site 685727007984 catalytic site [active] 685727007985 substrate binding site [chemical binding]; other site 685727007986 DNA primase; Validated; Region: dnaG; PRK05667 685727007987 CHC2 zinc finger; Region: zf-CHC2; cl17510 685727007988 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 685727007989 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 685727007990 active site 685727007991 metal binding site [ion binding]; metal-binding site 685727007992 interdomain interaction site; other site 685727007993 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 685727007994 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 685727007995 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 685727007996 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 685727007997 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 685727007998 putative active site [active] 685727007999 Repair protein; Region: Repair_PSII; pfam04536 685727008000 glycyl-tRNA synthetase; Provisional; Region: PRK04173 685727008001 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 685727008002 motif 1; other site 685727008003 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 685727008004 active site 685727008005 motif 2; other site 685727008006 motif 3; other site 685727008007 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 685727008008 anticodon binding site; other site 685727008009 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 685727008010 dimerization interface [polypeptide binding]; other site 685727008011 putative DNA binding site [nucleotide binding]; other site 685727008012 putative Zn2+ binding site [ion binding]; other site 685727008013 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 685727008014 metal binding site 2 [ion binding]; metal-binding site 685727008015 putative DNA binding helix; other site 685727008016 metal binding site 1 [ion binding]; metal-binding site 685727008017 dimer interface [polypeptide binding]; other site 685727008018 structural Zn2+ binding site [ion binding]; other site 685727008019 alternate signal-mediated exported protein, RER_14450 family; Region: exp_by_SipW_III; TIGR04089 685727008020 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 685727008021 Catalytic site [active] 685727008022 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 685727008023 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 685727008024 Catalytic site [active] 685727008025 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 685727008026 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 685727008027 catalytic residue [active] 685727008028 putative FPP diphosphate binding site; other site 685727008029 putative FPP binding hydrophobic cleft; other site 685727008030 dimer interface [polypeptide binding]; other site 685727008031 putative IPP diphosphate binding site; other site 685727008032 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 685727008033 Recombination protein O N terminal; Region: RecO_N; pfam11967 685727008034 Recombination protein O C terminal; Region: RecO_C; pfam02565 685727008035 amidase; Provisional; Region: PRK06061 685727008036 Amidase; Region: Amidase; cl11426 685727008037 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 685727008038 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727008039 GTPase Era; Reviewed; Region: era; PRK00089 685727008040 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 685727008041 G1 box; other site 685727008042 GTP/Mg2+ binding site [chemical binding]; other site 685727008043 Switch I region; other site 685727008044 G2 box; other site 685727008045 Switch II region; other site 685727008046 G3 box; other site 685727008047 G4 box; other site 685727008048 G5 box; other site 685727008049 KH domain; Region: KH_2; pfam07650 685727008050 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 685727008051 Domain of unknown function DUF21; Region: DUF21; pfam01595 685727008052 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 685727008053 Transporter associated domain; Region: CorC_HlyC; smart01091 685727008054 metal-binding heat shock protein; Provisional; Region: PRK00016 685727008055 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 685727008056 PhoH-like protein; Region: PhoH; pfam02562 685727008057 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727008058 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727008059 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 685727008060 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727008061 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 685727008062 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 685727008063 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 685727008064 RNA methyltransferase, RsmE family; Region: TIGR00046 685727008065 chaperone protein DnaJ; Provisional; Region: PRK14278 685727008066 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 685727008067 HSP70 interaction site [polypeptide binding]; other site 685727008068 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 685727008069 Zn binding sites [ion binding]; other site 685727008070 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 685727008071 dimer interface [polypeptide binding]; other site 685727008072 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 685727008073 HTH domain; Region: HTH_11; cl17392 685727008074 Ribosomal protein S19e; Region: Ribosomal_S19e; cl00969 685727008075 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 685727008076 coproporphyrinogen III oxidase; Validated; Region: PRK05628 685727008077 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 685727008078 FeS/SAM binding site; other site 685727008079 HemN C-terminal domain; Region: HemN_C; pfam06969 685727008080 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 685727008081 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 685727008082 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 685727008083 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 685727008084 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 685727008085 Active Sites [active] 685727008086 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 685727008087 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 685727008088 Active Sites [active] 685727008089 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 685727008090 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 685727008091 CysD dimerization site [polypeptide binding]; other site 685727008092 G1 box; other site 685727008093 putative GEF interaction site [polypeptide binding]; other site 685727008094 GTP/Mg2+ binding site [chemical binding]; other site 685727008095 Switch I region; other site 685727008096 G2 box; other site 685727008097 G3 box; other site 685727008098 Switch II region; other site 685727008099 G4 box; other site 685727008100 G5 box; other site 685727008101 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 685727008102 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 685727008103 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 685727008104 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 685727008105 putative active site [active] 685727008106 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 685727008107 putative active site [active] 685727008108 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 685727008109 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 685727008110 hypothetical protein; Provisional; Region: PRK07758 685727008111 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 685727008112 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 685727008113 Beta-lactamase; Region: Beta-lactamase; pfam00144 685727008114 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 685727008115 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 685727008116 Walker A/P-loop; other site 685727008117 ATP binding site [chemical binding]; other site 685727008118 Q-loop/lid; other site 685727008119 ABC transporter signature motif; other site 685727008120 Walker B; other site 685727008121 D-loop; other site 685727008122 H-loop/switch region; other site 685727008123 TOBE domain; Region: TOBE; pfam03459 685727008124 sulfate transport protein; Provisional; Region: cysT; CHL00187 685727008125 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685727008126 dimer interface [polypeptide binding]; other site 685727008127 conserved gate region; other site 685727008128 putative PBP binding loops; other site 685727008129 ABC-ATPase subunit interface; other site 685727008130 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 685727008131 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685727008132 dimer interface [polypeptide binding]; other site 685727008133 conserved gate region; other site 685727008134 putative PBP binding loops; other site 685727008135 ABC-ATPase subunit interface; other site 685727008136 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 685727008137 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 685727008138 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 685727008139 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 685727008140 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 685727008141 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 685727008142 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 685727008143 Nitronate monooxygenase; Region: NMO; pfam03060 685727008144 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 685727008145 FMN binding site [chemical binding]; other site 685727008146 substrate binding site [chemical binding]; other site 685727008147 putative catalytic residue [active] 685727008148 GTP-binding protein LepA; Provisional; Region: PRK05433 685727008149 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 685727008150 G1 box; other site 685727008151 putative GEF interaction site [polypeptide binding]; other site 685727008152 GTP/Mg2+ binding site [chemical binding]; other site 685727008153 Switch I region; other site 685727008154 G2 box; other site 685727008155 G3 box; other site 685727008156 Switch II region; other site 685727008157 G4 box; other site 685727008158 G5 box; other site 685727008159 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 685727008160 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 685727008161 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 685727008162 PemK-like protein; Region: PemK; pfam02452 685727008163 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 685727008164 amphipathic channel; other site 685727008165 Asn-Pro-Ala signature motifs; other site 685727008166 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 685727008167 hypothetical protein; Reviewed; Region: PRK07914 685727008168 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 685727008169 Competence protein; Region: Competence; pfam03772 685727008170 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 685727008171 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 685727008172 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 685727008173 EDD domain protein, DegV family; Region: DegV; TIGR00762 685727008174 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 685727008175 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 685727008176 active site 685727008177 catalytic triad [active] 685727008178 oxyanion hole [active] 685727008179 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 685727008180 catalytic core [active] 685727008181 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 685727008182 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 685727008183 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 685727008184 active site 685727008185 (T/H)XGH motif; other site 685727008186 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 685727008187 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685727008188 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 685727008189 Walker A motif; other site 685727008190 ATP binding site [chemical binding]; other site 685727008191 Walker B motif; other site 685727008192 arginine finger; other site 685727008193 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 685727008194 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 685727008195 putative catalytic cysteine [active] 685727008196 phenylalanine transporter; Provisional; Region: PRK10249 685727008197 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 685727008198 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 685727008199 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 685727008200 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 685727008201 Coenzyme A binding pocket [chemical binding]; other site 685727008202 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 685727008203 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 685727008204 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 685727008205 ATP binding site [chemical binding]; other site 685727008206 putative Mg++ binding site [ion binding]; other site 685727008207 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 685727008208 nucleotide binding region [chemical binding]; other site 685727008209 ATP-binding site [chemical binding]; other site 685727008210 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 685727008211 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 685727008212 Coenzyme A binding pocket [chemical binding]; other site 685727008213 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 685727008214 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 685727008215 inhibitor-cofactor binding pocket; inhibition site 685727008216 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685727008217 catalytic residue [active] 685727008218 L-ectoine synthase; Reviewed; Region: ectC; PRK13290 685727008219 Predicted membrane protein [Function unknown]; Region: COG1511 685727008220 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 685727008221 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 685727008222 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 685727008223 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 685727008224 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 685727008225 putative dimer interface [polypeptide binding]; other site 685727008226 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 685727008227 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 685727008228 NAD-dependent deacetylase; Provisional; Region: PRK05333 685727008229 NAD+ binding site [chemical binding]; other site 685727008230 substrate binding site [chemical binding]; other site 685727008231 Zn binding site [ion binding]; other site 685727008232 gamma-glutamyl kinase; Provisional; Region: PRK05429 685727008233 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 685727008234 nucleotide binding site [chemical binding]; other site 685727008235 homotetrameric interface [polypeptide binding]; other site 685727008236 putative phosphate binding site [ion binding]; other site 685727008237 putative allosteric binding site; other site 685727008238 PUA domain; Region: PUA; pfam01472 685727008239 GTPase CgtA; Reviewed; Region: obgE; PRK12296 685727008240 GTP1/OBG; Region: GTP1_OBG; pfam01018 685727008241 Obg GTPase; Region: Obg; cd01898 685727008242 G1 box; other site 685727008243 GTP/Mg2+ binding site [chemical binding]; other site 685727008244 Switch I region; other site 685727008245 G2 box; other site 685727008246 G3 box; other site 685727008247 Switch II region; other site 685727008248 G4 box; other site 685727008249 G5 box; other site 685727008250 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 685727008251 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 685727008252 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 685727008253 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 685727008254 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 685727008255 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 685727008256 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 685727008257 homodimer interface [polypeptide binding]; other site 685727008258 oligonucleotide binding site [chemical binding]; other site 685727008259 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 685727008260 active site 685727008261 multimer interface [polypeptide binding]; other site 685727008262 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 685727008263 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 685727008264 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 685727008265 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 685727008266 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 685727008267 active site 685727008268 HIGH motif; other site 685727008269 nucleotide binding site [chemical binding]; other site 685727008270 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 685727008271 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 685727008272 active site 685727008273 KMSKS motif; other site 685727008274 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 685727008275 tRNA binding surface [nucleotide binding]; other site 685727008276 anticodon binding site; other site 685727008277 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 685727008278 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 685727008279 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 685727008280 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 685727008281 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 685727008282 siderophore binding site; other site 685727008283 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 685727008284 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 685727008285 Secretory lipase; Region: LIP; pfam03583 685727008286 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727008287 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727008288 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 685727008289 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 685727008290 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685727008291 Walker A motif; other site 685727008292 ATP binding site [chemical binding]; other site 685727008293 Walker B motif; other site 685727008294 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 685727008295 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 685727008296 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 685727008297 oligomer interface [polypeptide binding]; other site 685727008298 active site residues [active] 685727008299 Clp protease; Region: CLP_protease; pfam00574 685727008300 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 685727008301 oligomer interface [polypeptide binding]; other site 685727008302 active site residues [active] 685727008303 trigger factor; Provisional; Region: tig; PRK01490 685727008304 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 685727008305 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 685727008306 Nitronate monooxygenase; Region: NMO; pfam03060 685727008307 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 685727008308 FMN binding site [chemical binding]; other site 685727008309 substrate binding site [chemical binding]; other site 685727008310 putative catalytic residue [active] 685727008311 DNA polymerase IV; Validated; Region: PRK03858 685727008312 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 685727008313 active site 685727008314 DNA binding site [nucleotide binding] 685727008315 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 685727008316 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 685727008317 putative DNA binding site [nucleotide binding]; other site 685727008318 catalytic residue [active] 685727008319 putative H2TH interface [polypeptide binding]; other site 685727008320 putative catalytic residues [active] 685727008321 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 685727008322 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 685727008323 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 685727008324 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 685727008325 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 685727008326 catalytic residues [active] 685727008327 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 685727008328 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 685727008329 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 685727008330 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 685727008331 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 685727008332 Zn binding site [ion binding]; other site 685727008333 Repair protein; Region: Repair_PSII; pfam04536 685727008334 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 685727008335 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 685727008336 active site 685727008337 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 685727008338 apolar tunnel; other site 685727008339 heme binding site [chemical binding]; other site 685727008340 dimerization interface [polypeptide binding]; other site 685727008341 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 685727008342 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 685727008343 active site 685727008344 catalytic site [active] 685727008345 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 685727008346 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12835 685727008347 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 685727008348 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727008349 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 685727008350 NAD(P) binding site [chemical binding]; other site 685727008351 active site 685727008352 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 685727008353 Transcriptional regulator [Transcription]; Region: IclR; COG1414 685727008354 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 685727008355 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 685727008356 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 685727008357 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 685727008358 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 685727008359 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 685727008360 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365 685727008361 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 685727008362 putative active site [active] 685727008363 Fe(II) binding site [ion binding]; other site 685727008364 putative dimer interface [polypeptide binding]; other site 685727008365 putative tetramer interface [polypeptide binding]; other site 685727008366 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 685727008367 Cytochrome P450; Region: p450; cl12078 685727008368 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727008369 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727008370 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 685727008371 active site 685727008372 catalytic site [active] 685727008373 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 685727008374 active site 685727008375 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 685727008376 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 685727008377 active site 685727008378 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 685727008379 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685727008380 Walker A/P-loop; other site 685727008381 ATP binding site [chemical binding]; other site 685727008382 Q-loop/lid; other site 685727008383 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 685727008384 ABC transporter; Region: ABC_tran_2; pfam12848 685727008385 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 685727008386 Secretory lipase; Region: LIP; pfam03583 685727008387 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 685727008388 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 685727008389 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 685727008390 dimer interface [polypeptide binding]; other site 685727008391 ssDNA binding site [nucleotide binding]; other site 685727008392 tetramer (dimer of dimers) interface [polypeptide binding]; other site 685727008393 Copper resistance protein D; Region: CopD; cl00563 685727008394 Copper resistance protein D; Region: CopD; pfam05425 685727008395 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 685727008396 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 685727008397 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 685727008398 metal ion-dependent adhesion site (MIDAS); other site 685727008399 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 685727008400 putative hydrophobic ligand binding site [chemical binding]; other site 685727008401 MoxR-like ATPases [General function prediction only]; Region: COG0714 685727008402 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 685727008403 Ligand binding site; other site 685727008404 metal-binding site 685727008405 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 685727008406 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 685727008407 XdhC Rossmann domain; Region: XdhC_C; pfam13478 685727008408 metallochaperone-like domain; Region: TRASH; smart00746 685727008409 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 685727008410 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 685727008411 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 685727008412 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 685727008413 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 685727008414 catalytic loop [active] 685727008415 iron binding site [ion binding]; other site 685727008416 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 685727008417 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 685727008418 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 685727008419 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 685727008420 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 685727008421 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 685727008422 XdhC Rossmann domain; Region: XdhC_C; pfam13478 685727008423 Transcriptional regulator [Transcription]; Region: LysR; COG0583 685727008424 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685727008425 LysR substrate binding domain; Region: LysR_substrate; pfam03466 685727008426 dimerization interface [polypeptide binding]; other site 685727008427 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 685727008428 Lipase (class 2); Region: Lipase_2; pfam01674 685727008429 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 685727008430 glutamate dehydrogenase; Provisional; Region: PRK09414 685727008431 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 685727008432 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 685727008433 NAD(P) binding site [chemical binding]; other site 685727008434 Fatty acid desaturase; Region: FA_desaturase; pfam00487 685727008435 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 685727008436 putative di-iron ligands [ion binding]; other site 685727008437 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 685727008438 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 685727008439 FAD binding pocket [chemical binding]; other site 685727008440 FAD binding motif [chemical binding]; other site 685727008441 phosphate binding motif [ion binding]; other site 685727008442 beta-alpha-beta structure motif; other site 685727008443 NAD binding pocket [chemical binding]; other site 685727008444 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 685727008445 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 685727008446 catalytic loop [active] 685727008447 iron binding site [ion binding]; other site 685727008448 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 685727008449 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727008450 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 685727008451 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 685727008452 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727008453 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 685727008454 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 685727008455 Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Region: SLC5sbd_DUR3; cd11476 685727008456 Na binding site [ion binding]; other site 685727008457 Predicted transcriptional regulators [Transcription]; Region: COG1695 685727008458 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 685727008459 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 685727008460 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 685727008461 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 685727008462 active site 685727008463 FMN binding site [chemical binding]; other site 685727008464 2,4-decadienoyl-CoA binding site; other site 685727008465 catalytic residue [active] 685727008466 4Fe-4S cluster binding site [ion binding]; other site 685727008467 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 685727008468 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 685727008469 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727008470 NAD(P) binding site [chemical binding]; other site 685727008471 active site 685727008472 diaminopimelate decarboxylase; Region: lysA; TIGR01048 685727008473 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 685727008474 active site 685727008475 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 685727008476 substrate binding site [chemical binding]; other site 685727008477 catalytic residues [active] 685727008478 dimer interface [polypeptide binding]; other site 685727008479 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 685727008480 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 685727008481 NAD binding site [chemical binding]; other site 685727008482 catalytic Zn binding site [ion binding]; other site 685727008483 substrate binding site [chemical binding]; other site 685727008484 structural Zn binding site [ion binding]; other site 685727008485 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 685727008486 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 685727008487 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 685727008488 catalytic site [active] 685727008489 putative active site [active] 685727008490 putative substrate binding site [chemical binding]; other site 685727008491 dimer interface [polypeptide binding]; other site 685727008492 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 685727008493 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 685727008494 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 685727008495 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 685727008496 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 685727008497 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 685727008498 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 685727008499 catalytic triad [active] 685727008500 hypothetical protein; Provisional; Region: PRK07907 685727008501 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 685727008502 active site 685727008503 metal binding site [ion binding]; metal-binding site 685727008504 dimer interface [polypeptide binding]; other site 685727008505 DEAD-like helicases superfamily; Region: DEXDc; smart00487 685727008506 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 685727008507 ATP binding site [chemical binding]; other site 685727008508 putative Mg++ binding site [ion binding]; other site 685727008509 Helicase_C-like; Region: Helicase_C_4; pfam13871 685727008510 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727008511 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727008512 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 685727008513 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685727008514 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 685727008515 Walker A/P-loop; other site 685727008516 ATP binding site [chemical binding]; other site 685727008517 Q-loop/lid; other site 685727008518 ABC transporter signature motif; other site 685727008519 Walker B; other site 685727008520 D-loop; other site 685727008521 H-loop/switch region; other site 685727008522 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 685727008523 ABC-2 type transporter; Region: ABC2_membrane; cl17235 685727008524 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727008525 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727008526 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 685727008527 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 685727008528 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 685727008529 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 685727008530 phosphate binding site [ion binding]; other site 685727008531 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 685727008532 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 685727008533 active site 2 [active] 685727008534 active site 1 [active] 685727008535 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 685727008536 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 685727008537 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 685727008538 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 685727008539 putative NAD(P) binding site [chemical binding]; other site 685727008540 active site 685727008541 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 685727008542 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 685727008543 active site 685727008544 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 685727008545 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 685727008546 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 685727008547 Amidohydrolase; Region: Amidohydro_4; pfam13147 685727008548 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 685727008549 active site 685727008550 signal recognition particle protein; Provisional; Region: PRK10867 685727008551 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 685727008552 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 685727008553 P loop; other site 685727008554 GTP binding site [chemical binding]; other site 685727008555 Signal peptide binding domain; Region: SRP_SPB; pfam02978 685727008556 PII uridylyl-transferase; Provisional; Region: PRK03381 685727008557 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 685727008558 metal binding triad; other site 685727008559 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 685727008560 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 685727008561 Zn2+ binding site [ion binding]; other site 685727008562 Mg2+ binding site [ion binding]; other site 685727008563 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 685727008564 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 685727008565 Nitrogen regulatory protein P-II; Region: P-II; smart00938 685727008566 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 685727008567 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 685727008568 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 685727008569 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 685727008570 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 685727008571 catalytic residues [active] 685727008572 dimer interface [polypeptide binding]; other site 685727008573 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 685727008574 AAA domain; Region: AAA_23; pfam13476 685727008575 Walker A/P-loop; other site 685727008576 ATP binding site [chemical binding]; other site 685727008577 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 685727008578 ABC transporter signature motif; other site 685727008579 Walker B; other site 685727008580 D-loop; other site 685727008581 H-loop/switch region; other site 685727008582 Acylphosphatase; Region: Acylphosphatase; cl00551 685727008583 Domain of unknown function (DUF222); Region: DUF222; pfam02720 685727008584 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 685727008585 active site 685727008586 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 685727008587 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 685727008588 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 685727008589 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 685727008590 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685727008591 active site 685727008592 phosphorylation site [posttranslational modification] 685727008593 intermolecular recognition site; other site 685727008594 dimerization interface [polypeptide binding]; other site 685727008595 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 685727008596 DNA binding site [nucleotide binding] 685727008597 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 685727008598 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 685727008599 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 685727008600 Ligand Binding Site [chemical binding]; other site 685727008601 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 685727008602 dimer interface [polypeptide binding]; other site 685727008603 phosphorylation site [posttranslational modification] 685727008604 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685727008605 Mg2+ binding site [ion binding]; other site 685727008606 G-X-G motif; other site 685727008607 K+-transporting ATPase, c chain; Region: KdpC; cl00944 685727008608 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 685727008609 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 685727008610 Soluble P-type ATPase [General function prediction only]; Region: COG4087 685727008611 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 685727008612 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 685727008613 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 685727008614 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 685727008615 DNA-binding site [nucleotide binding]; DNA binding site 685727008616 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 685727008617 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685727008618 homodimer interface [polypeptide binding]; other site 685727008619 catalytic residue [active] 685727008620 ribonuclease III; Reviewed; Region: rnc; PRK00102 685727008621 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 685727008622 dimerization interface [polypeptide binding]; other site 685727008623 active site 685727008624 metal binding site [ion binding]; metal-binding site 685727008625 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 685727008626 dsRNA binding site [nucleotide binding]; other site 685727008627 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 685727008628 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 685727008629 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 685727008630 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 685727008631 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 685727008632 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 685727008633 active site 685727008634 (T/H)XGH motif; other site 685727008635 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685727008636 S-adenosylmethionine binding site [chemical binding]; other site 685727008637 pyruvate carboxylase; Reviewed; Region: PRK12999 685727008638 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 685727008639 ATP-grasp domain; Region: ATP-grasp_4; cl17255 685727008640 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 685727008641 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 685727008642 active site 685727008643 catalytic residues [active] 685727008644 metal binding site [ion binding]; metal-binding site 685727008645 homodimer binding site [polypeptide binding]; other site 685727008646 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 685727008647 carboxyltransferase (CT) interaction site; other site 685727008648 biotinylation site [posttranslational modification]; other site 685727008649 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 685727008650 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 685727008651 generic binding surface II; other site 685727008652 ssDNA binding site; other site 685727008653 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 685727008654 ATP binding site [chemical binding]; other site 685727008655 putative Mg++ binding site [ion binding]; other site 685727008656 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 685727008657 nucleotide binding region [chemical binding]; other site 685727008658 ATP-binding site [chemical binding]; other site 685727008659 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 685727008660 DAK2 domain; Region: Dak2; cl03685 685727008661 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 685727008662 enoyl-CoA hydratase; Provisional; Region: PRK07260 685727008663 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 685727008664 substrate binding site [chemical binding]; other site 685727008665 oxyanion hole (OAH) forming residues; other site 685727008666 trimer interface [polypeptide binding]; other site 685727008667 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 685727008668 ligand binding site [chemical binding]; other site 685727008669 active site 685727008670 UGI interface [polypeptide binding]; other site 685727008671 catalytic site [active] 685727008672 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 685727008673 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 685727008674 trimer interface [polypeptide binding]; other site 685727008675 putative metal binding site [ion binding]; other site 685727008676 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 685727008677 ATP binding site [chemical binding]; other site 685727008678 dimerization interface [polypeptide binding]; other site 685727008679 thiamine monophosphate kinase; Provisional; Region: PRK05731 685727008680 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 685727008681 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 685727008682 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 685727008683 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 685727008684 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 685727008685 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 685727008686 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 685727008687 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 685727008688 2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552 685727008689 polyphosphate kinase; Provisional; Region: PRK05443 685727008690 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 685727008691 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 685727008692 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 685727008693 putative domain interface [polypeptide binding]; other site 685727008694 putative active site [active] 685727008695 catalytic site [active] 685727008696 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 685727008697 putative domain interface [polypeptide binding]; other site 685727008698 putative active site [active] 685727008699 catalytic site [active] 685727008700 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 685727008701 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 685727008702 catalytic core [active] 685727008703 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 685727008704 IHF dimer interface [polypeptide binding]; other site 685727008705 IHF - DNA interface [nucleotide binding]; other site 685727008706 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 685727008707 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 685727008708 substrate binding site [chemical binding]; other site 685727008709 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 685727008710 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 685727008711 substrate binding site [chemical binding]; other site 685727008712 ligand binding site [chemical binding]; other site 685727008713 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 685727008714 Transcriptional regulator [Transcription]; Region: IclR; COG1414 685727008715 Bacterial transcriptional regulator; Region: IclR; pfam01614 685727008716 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 685727008717 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 685727008718 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 685727008719 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 685727008720 HIGH motif; other site 685727008721 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 685727008722 active site 685727008723 KMSKS motif; other site 685727008724 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 685727008725 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 685727008726 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 685727008727 Major Facilitator Superfamily; Region: MFS_1; pfam07690 685727008728 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727008729 putative substrate translocation pore; other site 685727008730 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 685727008731 tartrate dehydrogenase; Region: TTC; TIGR02089 685727008732 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 685727008733 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 685727008734 ligand binding site [chemical binding]; other site 685727008735 NAD binding site [chemical binding]; other site 685727008736 dimerization interface [polypeptide binding]; other site 685727008737 catalytic site [active] 685727008738 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 685727008739 ketol-acid reductoisomerase; Provisional; Region: PRK05479 685727008740 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 685727008741 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 685727008742 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 685727008743 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 685727008744 putative valine binding site [chemical binding]; other site 685727008745 dimer interface [polypeptide binding]; other site 685727008746 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 685727008747 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 685727008748 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 685727008749 PYR/PP interface [polypeptide binding]; other site 685727008750 dimer interface [polypeptide binding]; other site 685727008751 TPP binding site [chemical binding]; other site 685727008752 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 685727008753 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 685727008754 TPP-binding site [chemical binding]; other site 685727008755 dimer interface [polypeptide binding]; other site 685727008756 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 685727008757 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 685727008758 Predicted membrane protein [Function unknown]; Region: COG2259 685727008759 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 685727008760 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 685727008761 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 685727008762 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 685727008763 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 685727008764 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 685727008765 GatB domain; Region: GatB_Yqey; smart00845 685727008766 6-phosphofructokinase; Provisional; Region: PRK03202 685727008767 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 685727008768 active site 685727008769 ADP/pyrophosphate binding site [chemical binding]; other site 685727008770 dimerization interface [polypeptide binding]; other site 685727008771 allosteric effector site; other site 685727008772 fructose-1,6-bisphosphate binding site; other site 685727008773 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 685727008774 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685727008775 active site 685727008776 phosphorylation site [posttranslational modification] 685727008777 intermolecular recognition site; other site 685727008778 dimerization interface [polypeptide binding]; other site 685727008779 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 685727008780 DNA binding residues [nucleotide binding] 685727008781 dimerization interface [polypeptide binding]; other site 685727008782 Histidine kinase; Region: HisKA_3; pfam07730 685727008783 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 685727008784 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 685727008785 Protein of unknown function (DUF664); Region: DUF664; pfam04978 685727008786 DinB superfamily; Region: DinB_2; pfam12867 685727008787 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 685727008788 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 685727008789 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 685727008790 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 685727008791 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 685727008792 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 685727008793 Coenzyme A binding pocket [chemical binding]; other site 685727008794 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 685727008795 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 685727008796 nucleotide binding pocket [chemical binding]; other site 685727008797 K-X-D-G motif; other site 685727008798 catalytic site [active] 685727008799 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 685727008800 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 685727008801 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 685727008802 Dimer interface [polypeptide binding]; other site 685727008803 BRCT sequence motif; other site 685727008804 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 685727008805 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 685727008806 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 685727008807 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 685727008808 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 685727008809 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 685727008810 catalytic residue [active] 685727008811 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 685727008812 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 685727008813 putative acyl-acceptor binding pocket; other site 685727008814 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 685727008815 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 685727008816 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 685727008817 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 685727008818 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 685727008819 Ligand binding site [chemical binding]; other site 685727008820 Electron transfer flavoprotein domain; Region: ETF; pfam01012 685727008821 Methyltransferase domain; Region: Methyltransf_23; pfam13489 685727008822 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685727008823 S-adenosylmethionine binding site [chemical binding]; other site 685727008824 Uncharacterized conserved protein [Function unknown]; Region: COG1543 685727008825 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 685727008826 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 685727008827 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 685727008828 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 685727008829 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 685727008830 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 685727008831 trimer interface [polypeptide binding]; other site 685727008832 active site 685727008833 substrate binding site [chemical binding]; other site 685727008834 CoA binding site [chemical binding]; other site 685727008835 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 685727008836 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 685727008837 hexamer interface [polypeptide binding]; other site 685727008838 ligand binding site [chemical binding]; other site 685727008839 putative active site [active] 685727008840 NAD(P) binding site [chemical binding]; other site 685727008841 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 685727008842 Trp docking motif [polypeptide binding]; other site 685727008843 PQQ-like domain; Region: PQQ_2; pfam13360 685727008844 active site 685727008845 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 685727008846 Methyltransferase domain; Region: Methyltransf_31; pfam13847 685727008847 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685727008848 S-adenosylmethionine binding site [chemical binding]; other site 685727008849 enoyl-CoA hydratase; Provisional; Region: PRK05862 685727008850 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 685727008851 substrate binding site [chemical binding]; other site 685727008852 oxyanion hole (OAH) forming residues; other site 685727008853 trimer interface [polypeptide binding]; other site 685727008854 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 685727008855 nudix motif; other site 685727008856 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 685727008857 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685727008858 Walker A/P-loop; other site 685727008859 ATP binding site [chemical binding]; other site 685727008860 Q-loop/lid; other site 685727008861 ABC transporter signature motif; other site 685727008862 Walker B; other site 685727008863 D-loop; other site 685727008864 H-loop/switch region; other site 685727008865 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 685727008866 dimer interface [polypeptide binding]; other site 685727008867 putative active site [active] 685727008868 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 685727008869 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 685727008870 phosphoserine phosphatase SerB; Region: serB; TIGR00338 685727008871 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685727008872 motif II; other site 685727008873 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 685727008874 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 685727008875 D-pathway; other site 685727008876 Putative ubiquinol binding site [chemical binding]; other site 685727008877 Low-spin heme (heme b) binding site [chemical binding]; other site 685727008878 Putative water exit pathway; other site 685727008879 Binuclear center (heme o3/CuB) [ion binding]; other site 685727008880 K-pathway; other site 685727008881 Putative proton exit pathway; other site 685727008882 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 685727008883 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 685727008884 siderophore binding site; other site 685727008885 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 685727008886 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 685727008887 intersubunit interface [polypeptide binding]; other site 685727008888 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 685727008889 nudix motif; other site 685727008890 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 685727008891 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 685727008892 RDD family; Region: RDD; cl00746 685727008893 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 685727008894 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 685727008895 dimer interface [polypeptide binding]; other site 685727008896 putative radical transfer pathway; other site 685727008897 diiron center [ion binding]; other site 685727008898 tyrosyl radical; other site 685727008899 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 685727008900 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 685727008901 Class I ribonucleotide reductase; Region: RNR_I; cd01679 685727008902 active site 685727008903 dimer interface [polypeptide binding]; other site 685727008904 catalytic residues [active] 685727008905 effector binding site; other site 685727008906 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 685727008907 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 685727008908 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 685727008909 catalytic residues [active] 685727008910 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 685727008911 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 685727008912 FAD binding pocket [chemical binding]; other site 685727008913 FAD binding motif [chemical binding]; other site 685727008914 phosphate binding motif [ion binding]; other site 685727008915 NAD binding pocket [chemical binding]; other site 685727008916 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 685727008917 Predicted flavoprotein [General function prediction only]; Region: COG0431 685727008918 META domain; Region: META; pfam03724 685727008919 META domain; Region: META; pfam03724 685727008920 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727008921 NADH(P)-binding; Region: NAD_binding_10; pfam13460 685727008922 NAD(P) binding site [chemical binding]; other site 685727008923 active site 685727008924 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 685727008925 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 685727008926 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 685727008927 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 685727008928 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 685727008929 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 685727008930 putative hydrophobic ligand binding site [chemical binding]; other site 685727008931 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 685727008932 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 685727008933 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 685727008934 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 685727008935 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 685727008936 catalytic loop [active] 685727008937 iron binding site [ion binding]; other site 685727008938 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 685727008939 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 685727008940 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 685727008941 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 685727008942 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 685727008943 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 685727008944 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 685727008945 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 685727008946 XdhC Rossmann domain; Region: XdhC_C; pfam13478 685727008947 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 685727008948 Amidase; Region: Amidase; cl11426 685727008949 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 685727008950 Ligand binding site; other site 685727008951 metal-binding site 685727008952 nucleosidase; Provisional; Region: PRK05634 685727008953 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 685727008954 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 685727008955 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 685727008956 homodimer interface [polypeptide binding]; other site 685727008957 NAD binding pocket [chemical binding]; other site 685727008958 ATP binding pocket [chemical binding]; other site 685727008959 Mg binding site [ion binding]; other site 685727008960 active-site loop [active] 685727008961 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727008962 NADH(P)-binding; Region: NAD_binding_10; pfam13460 685727008963 NAD(P) binding site [chemical binding]; other site 685727008964 active site 685727008965 Ubiquitin-like proteins; Region: UBQ; cl00155 685727008966 charged pocket; other site 685727008967 hydrophobic patch; other site 685727008968 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 685727008969 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 685727008970 FeS/SAM binding site; other site 685727008971 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 685727008972 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 685727008973 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 685727008974 dimer interface [polypeptide binding]; other site 685727008975 putative functional site; other site 685727008976 putative MPT binding site; other site 685727008977 bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional; Region: moaC; PRK03604 685727008978 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 685727008979 trimer interface [polypeptide binding]; other site 685727008980 dimer interface [polypeptide binding]; other site 685727008981 putative active site [active] 685727008982 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 685727008983 MPT binding site; other site 685727008984 trimer interface [polypeptide binding]; other site 685727008985 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 685727008986 MoaE homodimer interface [polypeptide binding]; other site 685727008987 MoaD interaction [polypeptide binding]; other site 685727008988 active site residues [active] 685727008989 helicase 45; Provisional; Region: PTZ00424 685727008990 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 685727008991 ATP binding site [chemical binding]; other site 685727008992 putative Mg++ binding site [ion binding]; other site 685727008993 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 685727008994 nucleotide binding region [chemical binding]; other site 685727008995 ATP-binding site [chemical binding]; other site 685727008996 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 685727008997 putative FMN binding site [chemical binding]; other site 685727008998 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 685727008999 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 685727009000 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 685727009001 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 685727009002 active site residue [active] 685727009003 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 685727009004 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 685727009005 Thioredoxin; Region: Thioredoxin_4; cl17273 685727009006 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 685727009007 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727009008 Major Facilitator Superfamily; Region: MFS_1; pfam07690 685727009009 putative substrate translocation pore; other site 685727009010 phosphoglucomutase; Validated; Region: PRK07564 685727009011 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 685727009012 active site 685727009013 substrate binding site [chemical binding]; other site 685727009014 metal binding site [ion binding]; metal-binding site 685727009015 camphor resistance protein CrcB; Provisional; Region: PRK14211 685727009016 Protein of unknown function (DUF1365); Region: DUF1365; cl17838 685727009017 PGAP1-like protein; Region: PGAP1; pfam07819 685727009018 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 685727009019 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 685727009020 catalytic site [active] 685727009021 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 685727009022 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 685727009023 TAP-like protein; Region: Abhydrolase_4; pfam08386 685727009024 Secretory lipase; Region: LIP; pfam03583 685727009025 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 685727009026 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 685727009027 SmpB-tmRNA interface; other site 685727009028 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 685727009029 FtsX-like permease family; Region: FtsX; pfam02687 685727009030 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 685727009031 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685727009032 Walker A/P-loop; other site 685727009033 ATP binding site [chemical binding]; other site 685727009034 Q-loop/lid; other site 685727009035 ABC transporter signature motif; other site 685727009036 Walker B; other site 685727009037 D-loop; other site 685727009038 H-loop/switch region; other site 685727009039 Mechanosensitive ion channel; Region: MS_channel; pfam00924 685727009040 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 685727009041 peptide chain release factor 2; Validated; Region: prfB; PRK00578 685727009042 This domain is found in peptide chain release factors; Region: PCRF; smart00937 685727009043 RF-1 domain; Region: RF-1; pfam00472 685727009044 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 685727009045 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 685727009046 active site 685727009047 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 685727009048 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 685727009049 dimerization interface [polypeptide binding]; other site 685727009050 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 685727009051 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 685727009052 dimer interface [polypeptide binding]; other site 685727009053 phosphorylation site [posttranslational modification] 685727009054 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685727009055 ATP binding site [chemical binding]; other site 685727009056 Mg2+ binding site [ion binding]; other site 685727009057 G-X-G motif; other site 685727009058 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 685727009059 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685727009060 active site 685727009061 phosphorylation site [posttranslational modification] 685727009062 intermolecular recognition site; other site 685727009063 dimerization interface [polypeptide binding]; other site 685727009064 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 685727009065 DNA binding site [nucleotide binding] 685727009066 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 685727009067 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 685727009068 active site 685727009069 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 685727009070 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 685727009071 active site 685727009072 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 685727009073 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 685727009074 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 685727009075 acyl-CoA synthetase; Validated; Region: PRK07788 685727009076 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 685727009077 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 685727009078 acyl-activating enzyme (AAE) consensus motif; other site 685727009079 putative AMP binding site [chemical binding]; other site 685727009080 putative active site [active] 685727009081 putative CoA binding site [chemical binding]; other site 685727009082 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 685727009083 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 685727009084 hypothetical protein; Validated; Region: PRK00068 685727009085 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 685727009086 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 685727009087 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 685727009088 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 685727009089 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 685727009090 Protein of unknown function DUF45; Region: DUF45; cl00636 685727009091 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 685727009092 ABC1 family; Region: ABC1; pfam03109 685727009093 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 685727009094 active site 685727009095 ATP binding site [chemical binding]; other site 685727009096 Transcription factor WhiB; Region: Whib; pfam02467 685727009097 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 685727009098 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 685727009099 Family description; Region: UvrD_C_2; pfam13538 685727009100 HRDC domain; Region: HRDC; pfam00570 685727009101 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 685727009102 catalytic residues [active] 685727009103 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 685727009104 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 685727009105 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 685727009106 putative NADH binding site [chemical binding]; other site 685727009107 putative active site [active] 685727009108 nudix motif; other site 685727009109 putative metal binding site [ion binding]; other site 685727009110 Ion channel; Region: Ion_trans_2; pfam07885 685727009111 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 685727009112 TrkA-N domain; Region: TrkA_N; pfam02254 685727009113 Predicted membrane protein [Function unknown]; Region: COG4270 685727009114 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 685727009115 Part of AAA domain; Region: AAA_19; pfam13245 685727009116 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 685727009117 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 685727009118 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 685727009119 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 685727009120 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 685727009121 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 685727009122 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 685727009123 catalytic site [active] 685727009124 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 685727009125 active site 685727009126 DNA binding site [nucleotide binding] 685727009127 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 685727009128 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 685727009129 MPT binding site; other site 685727009130 Putative esterase; Region: Esterase; pfam00756 685727009131 GTPase RsgA; Reviewed; Region: PRK01889 685727009132 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 685727009133 GTPase/Zn-binding domain interface [polypeptide binding]; other site 685727009134 GTP/Mg2+ binding site [chemical binding]; other site 685727009135 G4 box; other site 685727009136 G5 box; other site 685727009137 G1 box; other site 685727009138 Switch I region; other site 685727009139 G2 box; other site 685727009140 G3 box; other site 685727009141 Switch II region; other site 685727009142 additional locus_tag=REQ_32840 685727009143 Predicted membrane protein [Function unknown]; Region: COG1511 685727009144 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 685727009145 active site 685727009146 diiron metal binding site [ion binding]; other site 685727009147 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 685727009148 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 685727009149 CoenzymeA binding site [chemical binding]; other site 685727009150 subunit interaction site [polypeptide binding]; other site 685727009151 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 685727009152 putative active site [active] 685727009153 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 685727009154 putative active site [active] 685727009155 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 685727009156 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 685727009157 active site 685727009158 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 685727009159 DNA binding site [nucleotide binding] 685727009160 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 685727009161 nitrite reductase subunit NirD; Provisional; Region: PRK14989 685727009162 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 685727009163 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 685727009164 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 685727009165 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 685727009166 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 685727009167 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 685727009168 [4Fe-4S] binding site [ion binding]; other site 685727009169 molybdopterin cofactor binding site; other site 685727009170 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 685727009171 molybdopterin cofactor binding site; other site 685727009172 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 685727009173 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 685727009174 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727009175 putative substrate translocation pore; other site 685727009176 Transcriptional regulators [Transcription]; Region: FadR; COG2186 685727009177 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 685727009178 DNA-binding site [nucleotide binding]; DNA binding site 685727009179 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 685727009180 TIGR02569 family protein; Region: TIGR02569_actnb 685727009181 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 685727009182 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 685727009183 ATP binding site [chemical binding]; other site 685727009184 substrate interface [chemical binding]; other site 685727009185 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 685727009186 active site residue [active] 685727009187 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 685727009188 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 685727009189 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727009190 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727009191 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 685727009192 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 685727009193 dinuclear metal binding motif [ion binding]; other site 685727009194 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 685727009195 DEAD-like helicases superfamily; Region: DEXDc; smart00487 685727009196 ATP binding site [chemical binding]; other site 685727009197 Mg++ binding site [ion binding]; other site 685727009198 motif III; other site 685727009199 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 685727009200 nucleotide binding region [chemical binding]; other site 685727009201 ATP-binding site [chemical binding]; other site 685727009202 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 685727009203 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 685727009204 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 685727009205 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 685727009206 Magnesium ion binding site [ion binding]; other site 685727009207 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 685727009208 catalytic core [active] 685727009209 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 685727009210 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 685727009211 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 685727009212 Transcription factor WhiB; Region: Whib; pfam02467 685727009213 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 685727009214 PAS domain; Region: PAS_9; pfam13426 685727009215 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 685727009216 Histidine kinase; Region: HisKA_2; pfam07568 685727009217 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685727009218 ATP binding site [chemical binding]; other site 685727009219 Mg2+ binding site [ion binding]; other site 685727009220 G-X-G motif; other site 685727009221 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 685727009222 carboxyltransferase (CT) interaction site; other site 685727009223 biotinylation site [posttranslational modification]; other site 685727009224 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 685727009225 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 685727009226 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 685727009227 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 685727009228 DNA binding residues [nucleotide binding] 685727009229 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 685727009230 putative deacylase active site [active] 685727009231 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 685727009232 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 685727009233 Uncharacterized conserved protein [Function unknown]; Region: COG2135 685727009234 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 685727009235 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 685727009236 hinge; other site 685727009237 active site 685727009238 Predicted GTPases [General function prediction only]; Region: COG1162 685727009239 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 685727009240 GTPase/Zn-binding domain interface [polypeptide binding]; other site 685727009241 GTP/Mg2+ binding site [chemical binding]; other site 685727009242 G4 box; other site 685727009243 G5 box; other site 685727009244 G1 box; other site 685727009245 Switch I region; other site 685727009246 G2 box; other site 685727009247 G3 box; other site 685727009248 Switch II region; other site 685727009249 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 685727009250 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 685727009251 active site 685727009252 FMN binding site [chemical binding]; other site 685727009253 substrate binding site [chemical binding]; other site 685727009254 putative catalytic residue [active] 685727009255 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 685727009256 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 685727009257 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 685727009258 putative di-iron ligands [ion binding]; other site 685727009259 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 685727009260 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 685727009261 putative di-iron ligands [ion binding]; other site 685727009262 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 685727009263 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 685727009264 FAD binding pocket [chemical binding]; other site 685727009265 FAD binding motif [chemical binding]; other site 685727009266 phosphate binding motif [ion binding]; other site 685727009267 beta-alpha-beta structure motif; other site 685727009268 NAD binding pocket [chemical binding]; other site 685727009269 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 685727009270 catalytic loop [active] 685727009271 iron binding site [ion binding]; other site 685727009272 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 685727009273 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 685727009274 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 685727009275 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 685727009276 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 685727009277 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 685727009278 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 685727009279 nucleotide binding region [chemical binding]; other site 685727009280 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 685727009281 30S subunit binding site; other site 685727009282 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 685727009283 lipoprotein LpqB; Provisional; Region: PRK13616 685727009284 Sporulation and spore germination; Region: Germane; pfam10646 685727009285 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 685727009286 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 685727009287 dimerization interface [polypeptide binding]; other site 685727009288 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 685727009289 dimer interface [polypeptide binding]; other site 685727009290 phosphorylation site [posttranslational modification] 685727009291 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685727009292 ATP binding site [chemical binding]; other site 685727009293 Mg2+ binding site [ion binding]; other site 685727009294 G-X-G motif; other site 685727009295 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 685727009296 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685727009297 active site 685727009298 phosphorylation site [posttranslational modification] 685727009299 intermolecular recognition site; other site 685727009300 dimerization interface [polypeptide binding]; other site 685727009301 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 685727009302 DNA binding site [nucleotide binding] 685727009303 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 685727009304 TMP-binding site; other site 685727009305 ATP-binding site [chemical binding]; other site 685727009306 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 685727009307 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 685727009308 active site 685727009309 Adenosylhomocysteinase; Provisional; Region: PTZ00075 685727009310 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 685727009311 homotetramer interface [polypeptide binding]; other site 685727009312 ligand binding site [chemical binding]; other site 685727009313 catalytic site [active] 685727009314 NAD binding site [chemical binding]; other site 685727009315 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727009316 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727009317 Rubredoxin [Energy production and conversion]; Region: COG1773 685727009318 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 685727009319 iron binding site [ion binding]; other site 685727009320 Rubredoxin [Energy production and conversion]; Region: COG1773 685727009321 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 685727009322 iron binding site [ion binding]; other site 685727009323 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 685727009324 Fatty acid desaturase; Region: FA_desaturase; pfam00487 685727009325 Di-iron ligands [ion binding]; other site 685727009326 amino acid transporter; Region: 2A0306; TIGR00909 685727009327 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 685727009328 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 685727009329 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 685727009330 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 685727009331 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 685727009332 active site 685727009333 substrate binding site [chemical binding]; other site 685727009334 metal binding site [ion binding]; metal-binding site 685727009335 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 685727009336 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 685727009337 Transcription factor WhiB; Region: Whib; pfam02467 685727009338 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 685727009339 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 685727009340 phosphate binding site [ion binding]; other site 685727009341 dimer interface [polypeptide binding]; other site 685727009342 substrate binding site [chemical binding]; other site 685727009343 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 685727009344 F420-0:gamma-glutamyl ligase; Region: F420_cofE; TIGR01916 685727009345 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 685727009346 putative FMN binding site [chemical binding]; other site 685727009347 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 685727009348 nudix motif; other site 685727009349 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 685727009350 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 685727009351 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 685727009352 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 685727009353 active site 685727009354 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 685727009355 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 685727009356 active site 685727009357 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 685727009358 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 685727009359 tetramer interface [polypeptide binding]; other site 685727009360 active site 685727009361 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 685727009362 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 685727009363 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 685727009364 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 685727009365 Bacterial transcriptional regulator; Region: IclR; pfam01614 685727009366 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 685727009367 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 685727009368 dimer interface [polypeptide binding]; other site 685727009369 active site 685727009370 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727009371 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 685727009372 NAD(P) binding site [chemical binding]; other site 685727009373 active site 685727009374 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 685727009375 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 685727009376 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 685727009377 Transcriptional regulator [Transcription]; Region: IclR; COG1414 685727009378 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 685727009379 non-specific DNA interactions [nucleotide binding]; other site 685727009380 DNA binding site [nucleotide binding] 685727009381 sequence specific DNA binding site [nucleotide binding]; other site 685727009382 putative cAMP binding site [chemical binding]; other site 685727009383 Bacterial transcriptional regulator; Region: IclR; pfam01614 685727009384 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727009385 Major Facilitator Superfamily; Region: MFS_1; pfam07690 685727009386 putative substrate translocation pore; other site 685727009387 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 685727009388 active site 685727009389 catalytic triad [active] 685727009390 oxyanion hole [active] 685727009391 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 685727009392 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 685727009393 active site 685727009394 Substrate binding site; other site 685727009395 Mg++ binding site; other site 685727009396 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 685727009397 putative trimer interface [polypeptide binding]; other site 685727009398 putative CoA binding site [chemical binding]; other site 685727009399 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 685727009400 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 685727009401 Probable Catalytic site; other site 685727009402 metal-binding site 685727009403 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 685727009404 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 685727009405 NADP binding site [chemical binding]; other site 685727009406 active site 685727009407 putative substrate binding site [chemical binding]; other site 685727009408 Transcriptional regulator [Transcription]; Region: LytR; COG1316 685727009409 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 685727009410 TIGR03089 family protein; Region: TIGR03089 685727009411 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 685727009412 FtsX-like permease family; Region: FtsX; pfam02687 685727009413 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 685727009414 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 685727009415 Walker A/P-loop; other site 685727009416 ATP binding site [chemical binding]; other site 685727009417 Q-loop/lid; other site 685727009418 ABC transporter signature motif; other site 685727009419 Walker B; other site 685727009420 D-loop; other site 685727009421 H-loop/switch region; other site 685727009422 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 685727009423 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685727009424 active site 685727009425 phosphorylation site [posttranslational modification] 685727009426 intermolecular recognition site; other site 685727009427 dimerization interface [polypeptide binding]; other site 685727009428 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 685727009429 DNA binding residues [nucleotide binding] 685727009430 dimerization interface [polypeptide binding]; other site 685727009431 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 685727009432 Histidine kinase; Region: HisKA_3; pfam07730 685727009433 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685727009434 ATP binding site [chemical binding]; other site 685727009435 Mg2+ binding site [ion binding]; other site 685727009436 G-X-G motif; other site 685727009437 AIR carboxylase; Region: AIRC; pfam00731 685727009438 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 685727009439 ATP-grasp domain; Region: ATP-grasp; pfam02222 685727009440 Predicted membrane protein [Function unknown]; Region: COG2246 685727009441 GtrA-like protein; Region: GtrA; pfam04138 685727009442 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 685727009443 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 685727009444 dimer interface [polypeptide binding]; other site 685727009445 phosphorylation site [posttranslational modification] 685727009446 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685727009447 ATP binding site [chemical binding]; other site 685727009448 Mg2+ binding site [ion binding]; other site 685727009449 G-X-G motif; other site 685727009450 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 685727009451 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685727009452 active site 685727009453 phosphorylation site [posttranslational modification] 685727009454 intermolecular recognition site; other site 685727009455 dimerization interface [polypeptide binding]; other site 685727009456 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 685727009457 DNA binding site [nucleotide binding] 685727009458 Bacterial PH domain; Region: DUF304; pfam03703 685727009459 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 685727009460 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 685727009461 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 685727009462 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 685727009463 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 685727009464 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 685727009465 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 685727009466 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 685727009467 Maf-like protein; Region: Maf; pfam02545 685727009468 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 685727009469 active site 685727009470 dimer interface [polypeptide binding]; other site 685727009471 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 685727009472 heme-binding site [chemical binding]; other site 685727009473 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 685727009474 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 685727009475 active site residue [active] 685727009476 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 685727009477 active site residue [active] 685727009478 Fe-S metabolism associated domain; Region: SufE; cl00951 685727009479 Condensation domain; Region: Condensation; pfam00668 685727009480 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 685727009481 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 685727009482 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 685727009483 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 685727009484 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 685727009485 carboxyltransferase (CT) interaction site; other site 685727009486 biotinylation site [posttranslational modification]; other site 685727009487 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 685727009488 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 685727009489 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 685727009490 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 685727009491 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 685727009492 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 685727009493 iron-sulfur cluster [ion binding]; other site 685727009494 [2Fe-2S] cluster binding site [ion binding]; other site 685727009495 L-lysine aminotransferase; Provisional; Region: PRK08297 685727009496 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 685727009497 inhibitor-cofactor binding pocket; inhibition site 685727009498 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685727009499 catalytic residue [active] 685727009500 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 685727009501 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 685727009502 aldehyde dehydrogenase family 7 member; Region: PLN02315 685727009503 tetrameric interface [polypeptide binding]; other site 685727009504 NAD binding site [chemical binding]; other site 685727009505 catalytic residues [active] 685727009506 short chain dehydrogenase; Provisional; Region: PRK07825 685727009507 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727009508 NAD(P) binding site [chemical binding]; other site 685727009509 active site 685727009510 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 685727009511 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 685727009512 Patatin-like phospholipase; Region: Patatin; pfam01734 685727009513 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 685727009514 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727009515 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727009516 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 685727009517 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 685727009518 ATP binding site [chemical binding]; other site 685727009519 putative Mg++ binding site [ion binding]; other site 685727009520 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 685727009521 nucleotide binding region [chemical binding]; other site 685727009522 ATP-binding site [chemical binding]; other site 685727009523 DEAD/H associated; Region: DEAD_assoc; pfam08494 685727009524 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 685727009525 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 685727009526 putative DNA binding site [nucleotide binding]; other site 685727009527 catalytic residue [active] 685727009528 putative H2TH interface [polypeptide binding]; other site 685727009529 putative catalytic residues [active] 685727009530 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 685727009531 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 685727009532 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 685727009533 glycerol kinase; Provisional; Region: glpK; PRK00047 685727009534 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 685727009535 N- and C-terminal domain interface [polypeptide binding]; other site 685727009536 active site 685727009537 MgATP binding site [chemical binding]; other site 685727009538 catalytic site [active] 685727009539 metal binding site [ion binding]; metal-binding site 685727009540 putative homotetramer interface [polypeptide binding]; other site 685727009541 glycerol binding site [chemical binding]; other site 685727009542 homodimer interface [polypeptide binding]; other site 685727009543 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 685727009544 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 685727009545 hydrophobic ligand binding site; other site 685727009546 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 685727009547 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 685727009548 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685727009549 homodimer interface [polypeptide binding]; other site 685727009550 catalytic residue [active] 685727009551 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 685727009552 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 685727009553 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 685727009554 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 685727009555 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 685727009556 putative active site pocket [active] 685727009557 dimerization interface [polypeptide binding]; other site 685727009558 putative catalytic residue [active] 685727009559 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 685727009560 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 685727009561 metal binding site [ion binding]; metal-binding site 685727009562 putative dimer interface [polypeptide binding]; other site 685727009563 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 685727009564 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 685727009565 metal binding site [ion binding]; metal-binding site 685727009566 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 685727009567 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 685727009568 substrate binding site [chemical binding]; other site 685727009569 oxyanion hole (OAH) forming residues; other site 685727009570 trimer interface [polypeptide binding]; other site 685727009571 purine nucleoside phosphorylase; Provisional; Region: PRK08202 685727009572 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 685727009573 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 685727009574 active site 685727009575 substrate binding site [chemical binding]; other site 685727009576 metal binding site [ion binding]; metal-binding site 685727009577 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 685727009578 Predicted membrane protein [Function unknown]; Region: COG3212 685727009579 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 685727009580 active site 685727009581 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 685727009582 NlpC/P60 family; Region: NLPC_P60; pfam00877 685727009583 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 685727009584 adenosine deaminase; Provisional; Region: PRK09358 685727009585 active site 685727009586 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 685727009587 putative Iron-sulfur protein interface [polypeptide binding]; other site 685727009588 putative proximal heme binding site [chemical binding]; other site 685727009589 putative SdhD-like interface [polypeptide binding]; other site 685727009590 putative distal heme binding site [chemical binding]; other site 685727009591 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 685727009592 putative Iron-sulfur protein interface [polypeptide binding]; other site 685727009593 putative proximal heme binding site [chemical binding]; other site 685727009594 putative SdhC-like subunit interface [polypeptide binding]; other site 685727009595 putative distal heme binding site [chemical binding]; other site 685727009596 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 685727009597 L-aspartate oxidase; Provisional; Region: PRK06175 685727009598 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 685727009599 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 685727009600 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 685727009601 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 685727009602 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 685727009603 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 685727009604 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 685727009605 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 685727009606 active site 685727009607 HIGH motif; other site 685727009608 dimer interface [polypeptide binding]; other site 685727009609 KMSKS motif; other site 685727009610 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 685727009611 RNAase interaction site [polypeptide binding]; other site 685727009612 ribonuclease; Region: Ribonuclease; pfam00545 685727009613 active site 685727009614 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 685727009615 putative active site [active] 685727009616 putative catalytic site [active] 685727009617 putative DNA binding site [nucleotide binding]; other site 685727009618 putative phosphate binding site [ion binding]; other site 685727009619 metal binding site A [ion binding]; metal-binding site 685727009620 putative AP binding site [nucleotide binding]; other site 685727009621 putative metal binding site B [ion binding]; other site 685727009622 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 685727009623 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727009624 putative substrate translocation pore; other site 685727009625 isocitrate dehydrogenase; Validated; Region: PRK08299 685727009626 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 685727009627 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 685727009628 homodimer interface [polypeptide binding]; other site 685727009629 substrate-cofactor binding pocket; other site 685727009630 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685727009631 catalytic residue [active] 685727009632 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 685727009633 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 685727009634 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 685727009635 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 685727009636 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 685727009637 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 685727009638 homodimer interface [polypeptide binding]; other site 685727009639 NADP binding site [chemical binding]; other site 685727009640 substrate binding site [chemical binding]; other site 685727009641 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 685727009642 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 685727009643 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 685727009644 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 685727009645 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 685727009646 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 685727009647 catalytic residues [active] 685727009648 Recombinase; Region: Recombinase; pfam07508 685727009649 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 685727009650 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 685727009651 Transcriptional regulator [Transcription]; Region: LysR; COG0583 685727009652 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685727009653 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 685727009654 putative dimerization interface [polypeptide binding]; other site 685727009655 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 685727009656 Putative esterase; Region: Esterase; pfam00756 685727009657 Transcriptional regulator [Transcription]; Region: LysR; COG0583 685727009658 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685727009659 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 685727009660 putative dimerization interface [polypeptide binding]; other site 685727009661 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 685727009662 gating phenylalanine in ion channel; other site 685727009663 Domain of unknown function DUF302; Region: DUF302; cl01364 685727009664 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 685727009665 putative homotetramer interface [polypeptide binding]; other site 685727009666 putative homodimer interface [polypeptide binding]; other site 685727009667 putative allosteric switch controlling residues; other site 685727009668 putative metal binding site [ion binding]; other site 685727009669 putative homodimer-homodimer interface [polypeptide binding]; other site 685727009670 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 685727009671 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 685727009672 active site residue [active] 685727009673 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 685727009674 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 685727009675 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 685727009676 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 685727009677 active site residue [active] 685727009678 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 685727009679 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 685727009680 active site 685727009681 PHP Thumb interface [polypeptide binding]; other site 685727009682 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 685727009683 generic binding surface II; other site 685727009684 generic binding surface I; other site 685727009685 Beta-lactamase; Region: Beta-lactamase; pfam00144 685727009686 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 685727009687 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685727009688 Helix-turn-helix domain; Region: HTH_18; pfam12833 685727009689 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 685727009690 active site 685727009691 catalytic triad [active] 685727009692 oxyanion hole [active] 685727009693 MMPL family; Region: MMPL; pfam03176 685727009694 short chain dehydrogenase; Provisional; Region: PRK07201 685727009695 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 685727009696 putative NAD(P) binding site [chemical binding]; other site 685727009697 active site 685727009698 putative substrate binding site [chemical binding]; other site 685727009699 classical (c) SDRs; Region: SDR_c; cd05233 685727009700 NAD(P) binding site [chemical binding]; other site 685727009701 active site 685727009702 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 685727009703 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 685727009704 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 685727009705 putative dimer interface [polypeptide binding]; other site 685727009706 putative [2Fe-2S] cluster binding site [ion binding]; other site 685727009707 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 685727009708 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 685727009709 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 685727009710 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 685727009711 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 685727009712 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 685727009713 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685727009714 motif II; other site 685727009715 DNA Polymerase Y-family; Region: PolY_like; cd03468 685727009716 active site 685727009717 DNA binding site [nucleotide binding] 685727009718 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 685727009719 Catalytic domain of Protein Kinases; Region: PKc; cd00180 685727009720 active site 685727009721 ATP binding site [chemical binding]; other site 685727009722 substrate binding site [chemical binding]; other site 685727009723 activation loop (A-loop); other site 685727009724 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 685727009725 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685727009726 active site 685727009727 phosphorylation site [posttranslational modification] 685727009728 intermolecular recognition site; other site 685727009729 dimerization interface [polypeptide binding]; other site 685727009730 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 685727009731 DNA binding residues [nucleotide binding] 685727009732 dimerization interface [polypeptide binding]; other site 685727009733 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 685727009734 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 685727009735 Mg2+ binding site [ion binding]; other site 685727009736 G-X-G motif; other site 685727009737 PspC domain; Region: PspC; pfam04024 685727009738 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 685727009739 GMP synthase; Reviewed; Region: guaA; PRK00074 685727009740 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 685727009741 AMP/PPi binding site [chemical binding]; other site 685727009742 candidate oxyanion hole; other site 685727009743 catalytic triad [active] 685727009744 potential glutamine specificity residues [chemical binding]; other site 685727009745 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 685727009746 ATP Binding subdomain [chemical binding]; other site 685727009747 Ligand Binding sites [chemical binding]; other site 685727009748 Dimerization subdomain; other site 685727009749 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 685727009750 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 685727009751 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 685727009752 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 685727009753 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 685727009754 active site 685727009755 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 685727009756 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 685727009757 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 685727009758 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 685727009759 active site 685727009760 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 685727009761 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 685727009762 DNA binding residues [nucleotide binding] 685727009763 Transcription factor WhiB; Region: Whib; pfam02467 685727009764 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 685727009765 Fasciclin domain; Region: Fasciclin; pfam02469 685727009766 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 685727009767 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 685727009768 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 685727009769 DNA binding residues [nucleotide binding] 685727009770 Anti-sigma-K factor rskA; Region: RskA; pfam10099 685727009771 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 685727009772 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 685727009773 ring oligomerisation interface [polypeptide binding]; other site 685727009774 ATP/Mg binding site [chemical binding]; other site 685727009775 stacking interactions; other site 685727009776 hinge regions; other site 685727009777 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 685727009778 oligomerisation interface [polypeptide binding]; other site 685727009779 mobile loop; other site 685727009780 roof hairpin; other site 685727009781 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 685727009782 CoenzymeA binding site [chemical binding]; other site 685727009783 subunit interaction site [polypeptide binding]; other site 685727009784 PHB binding site; other site 685727009785 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 685727009786 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 685727009787 NAD(P) binding site [chemical binding]; other site 685727009788 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 685727009789 iron-sulfur cluster [ion binding]; other site 685727009790 [2Fe-2S] cluster binding site [ion binding]; other site 685727009791 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 685727009792 beta subunit interface [polypeptide binding]; other site 685727009793 alpha subunit interface [polypeptide binding]; other site 685727009794 active site 685727009795 substrate binding site [chemical binding]; other site 685727009796 Fe binding site [ion binding]; other site 685727009797 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 685727009798 [2Fe-2S] cluster binding site [ion binding]; other site 685727009799 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 685727009800 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 685727009801 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 685727009802 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 685727009803 inter-subunit interface; other site 685727009804 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 685727009805 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 685727009806 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727009807 NAD(P) binding site [chemical binding]; other site 685727009808 active site 685727009809 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 685727009810 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 685727009811 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 685727009812 acyl-activating enzyme (AAE) consensus motif; other site 685727009813 putative AMP binding site [chemical binding]; other site 685727009814 putative active site [active] 685727009815 putative CoA binding site [chemical binding]; other site 685727009816 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 685727009817 Leucine carboxyl methyltransferase; Region: LCM; cl01306 685727009818 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 685727009819 putative catalytic site [active] 685727009820 putative metal binding site [ion binding]; other site 685727009821 putative phosphate binding site [ion binding]; other site 685727009822 Domain of unknown function (DUF222); Region: DUF222; pfam02720 685727009823 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 685727009824 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365 685727009825 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 685727009826 putative active site [active] 685727009827 Fe(II) binding site [ion binding]; other site 685727009828 putative dimer interface [polypeptide binding]; other site 685727009829 putative tetramer interface [polypeptide binding]; other site 685727009830 Transcriptional regulator [Transcription]; Region: IclR; COG1414 685727009831 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 685727009832 Bacterial transcriptional regulator; Region: IclR; pfam01614 685727009833 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 685727009834 non-specific DNA binding site [nucleotide binding]; other site 685727009835 salt bridge; other site 685727009836 sequence-specific DNA binding site [nucleotide binding]; other site 685727009837 Cupin domain; Region: Cupin_2; cl17218 685727009838 metallophosphoesterase, PPA1498 family; Region: P_acnes_RR; TIGR03767 685727009839 Ion channel; Region: Ion_trans_2; pfam07885 685727009840 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 685727009841 UGMP family protein; Validated; Region: PRK09604 685727009842 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 685727009843 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 685727009844 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 685727009845 Glycoprotease family; Region: Peptidase_M22; pfam00814 685727009846 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 685727009847 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 685727009848 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 685727009849 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 685727009850 TAP-like protein; Region: Abhydrolase_4; pfam08386 685727009851 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 685727009852 alanine racemase; Reviewed; Region: alr; PRK00053 685727009853 active site 685727009854 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 685727009855 dimer interface [polypeptide binding]; other site 685727009856 substrate binding site [chemical binding]; other site 685727009857 catalytic residues [active] 685727009858 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 685727009859 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 685727009860 putative substrate binding site [chemical binding]; other site 685727009861 putative ATP binding site [chemical binding]; other site 685727009862 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 685727009863 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 685727009864 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 685727009865 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 685727009866 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 685727009867 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 685727009868 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 685727009869 glutaminase active site [active] 685727009870 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 685727009871 dimer interface [polypeptide binding]; other site 685727009872 active site 685727009873 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 685727009874 dimer interface [polypeptide binding]; other site 685727009875 active site 685727009876 Chlorophyllase; Region: Chlorophyllase; pfam07224 685727009877 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 685727009878 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 685727009879 active site 685727009880 substrate binding site [chemical binding]; other site 685727009881 metal binding site [ion binding]; metal-binding site 685727009882 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 685727009883 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 685727009884 23S rRNA interface [nucleotide binding]; other site 685727009885 L3 interface [polypeptide binding]; other site 685727009886 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 685727009887 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 685727009888 inhibitor-cofactor binding pocket; inhibition site 685727009889 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685727009890 catalytic residue [active] 685727009891 Proteins of 100 residues with WXG; Region: WXG100; cl02005 685727009892 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 685727009893 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 685727009894 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 685727009895 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 685727009896 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 685727009897 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 685727009898 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 685727009899 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 685727009900 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 685727009901 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 685727009902 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 685727009903 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 685727009904 active site 685727009905 catalytic residues [active] 685727009906 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919 685727009907 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 685727009908 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 685727009909 Predicted flavoprotein [General function prediction only]; Region: COG0431 685727009910 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727009911 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727009912 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 685727009913 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 685727009914 active site 685727009915 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 685727009916 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 685727009917 dimerization interface 3.5A [polypeptide binding]; other site 685727009918 active site 685727009919 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 685727009920 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 685727009921 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 685727009922 alphaNTD - beta interaction site [polypeptide binding]; other site 685727009923 alphaNTD homodimer interface [polypeptide binding]; other site 685727009924 alphaNTD - beta' interaction site [polypeptide binding]; other site 685727009925 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 685727009926 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 685727009927 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 685727009928 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 685727009929 RNA binding surface [nucleotide binding]; other site 685727009930 30S ribosomal protein S11; Validated; Region: PRK05309 685727009931 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 685727009932 30S ribosomal protein S13; Region: bact_S13; TIGR03631 685727009933 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 685727009934 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 685727009935 rRNA binding site [nucleotide binding]; other site 685727009936 predicted 30S ribosome binding site; other site 685727009937 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cl00253 685727009938 putative active site [active] 685727009939 dimerization interface [polypeptide binding]; other site 685727009940 putative tRNAtyr binding site [nucleotide binding]; other site 685727009941 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 685727009942 active site 685727009943 adenylate kinase; Reviewed; Region: adk; PRK00279 685727009944 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 685727009945 AMP-binding site [chemical binding]; other site 685727009946 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 685727009947 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 685727009948 SecY translocase; Region: SecY; pfam00344 685727009949 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 685727009950 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 685727009951 23S rRNA binding site [nucleotide binding]; other site 685727009952 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 685727009953 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 685727009954 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 685727009955 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 685727009956 5S rRNA interface [nucleotide binding]; other site 685727009957 L27 interface [polypeptide binding]; other site 685727009958 23S rRNA interface [nucleotide binding]; other site 685727009959 L5 interface [polypeptide binding]; other site 685727009960 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 685727009961 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 685727009962 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 685727009963 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 685727009964 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 685727009965 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 685727009966 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 685727009967 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 685727009968 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 685727009969 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 685727009970 RNA binding site [nucleotide binding]; other site 685727009971 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 685727009972 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 685727009973 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 685727009974 23S rRNA interface [nucleotide binding]; other site 685727009975 putative translocon interaction site; other site 685727009976 signal recognition particle (SRP54) interaction site; other site 685727009977 L23 interface [polypeptide binding]; other site 685727009978 trigger factor interaction site; other site 685727009979 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 685727009980 23S rRNA interface [nucleotide binding]; other site 685727009981 5S rRNA interface [nucleotide binding]; other site 685727009982 putative antibiotic binding site [chemical binding]; other site 685727009983 L25 interface [polypeptide binding]; other site 685727009984 L27 interface [polypeptide binding]; other site 685727009985 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 685727009986 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 685727009987 G-X-X-G motif; other site 685727009988 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 685727009989 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 685727009990 protein-rRNA interface [nucleotide binding]; other site 685727009991 putative translocon binding site; other site 685727009992 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 685727009993 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 685727009994 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 685727009995 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 685727009996 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 685727009997 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 685727009998 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 685727009999 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 685727010000 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 685727010001 CoenzymeA binding site [chemical binding]; other site 685727010002 subunit interaction site [polypeptide binding]; other site 685727010003 PHB binding site; other site 685727010004 Transcriptional regulators [Transcription]; Region: GntR; COG1802 685727010005 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 685727010006 DNA-binding site [nucleotide binding]; DNA binding site 685727010007 FCD domain; Region: FCD; pfam07729 685727010008 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685727010009 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 685727010010 Walker A/P-loop; other site 685727010011 ATP binding site [chemical binding]; other site 685727010012 Q-loop/lid; other site 685727010013 ABC transporter signature motif; other site 685727010014 Walker B; other site 685727010015 D-loop; other site 685727010016 H-loop/switch region; other site 685727010017 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 685727010018 ABC-2 type transporter; Region: ABC2_membrane; cl17235 685727010019 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 685727010020 ABC-2 type transporter; Region: ABC2_membrane; cl17235 685727010021 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 685727010022 Lipase (class 2); Region: Lipase_2; pfam01674 685727010023 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 685727010024 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 685727010025 acyl-activating enzyme (AAE) consensus motif; other site 685727010026 AMP binding site [chemical binding]; other site 685727010027 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 685727010028 Condensation domain; Region: Condensation; pfam00668 685727010029 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 685727010030 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 685727010031 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 685727010032 acyl-activating enzyme (AAE) consensus motif; other site 685727010033 AMP binding site [chemical binding]; other site 685727010034 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 685727010035 Condensation domain; Region: Condensation; pfam00668 685727010036 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 685727010037 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 685727010038 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 685727010039 acyl-activating enzyme (AAE) consensus motif; other site 685727010040 AMP binding site [chemical binding]; other site 685727010041 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 685727010042 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 685727010043 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 685727010044 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 685727010045 acyl-activating enzyme (AAE) consensus motif; other site 685727010046 AMP binding site [chemical binding]; other site 685727010047 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 685727010048 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 685727010049 acyl-activating enzyme (AAE) consensus motif; other site 685727010050 AMP binding site [chemical binding]; other site 685727010051 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 685727010052 Condensation domain; Region: Condensation; pfam00668 685727010053 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 685727010054 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 685727010055 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 685727010056 acyl-activating enzyme (AAE) consensus motif; other site 685727010057 AMP binding site [chemical binding]; other site 685727010058 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 685727010059 Condensation domain; Region: Condensation; pfam00668 685727010060 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 685727010061 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 685727010062 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 685727010063 acyl-activating enzyme (AAE) consensus motif; other site 685727010064 AMP binding site [chemical binding]; other site 685727010065 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 685727010066 Condensation domain; Region: Condensation; pfam00668 685727010067 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 685727010068 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 685727010069 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 685727010070 Condensation domain; Region: Condensation; pfam00668 685727010071 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 685727010072 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 685727010073 acyl-activating enzyme (AAE) consensus motif; other site 685727010074 AMP binding site [chemical binding]; other site 685727010075 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 685727010076 Condensation domain; Region: Condensation; pfam00668 685727010077 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 685727010078 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 685727010079 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 685727010080 acyl-activating enzyme (AAE) consensus motif; other site 685727010081 AMP binding site [chemical binding]; other site 685727010082 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 685727010083 Condensation domain; Region: Condensation; pfam00668 685727010084 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 685727010085 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 685727010086 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 685727010087 acyl-activating enzyme (AAE) consensus motif; other site 685727010088 AMP binding site [chemical binding]; other site 685727010089 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 685727010090 Condensation domain; Region: Condensation; pfam00668 685727010091 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 685727010092 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 685727010093 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 685727010094 acyl-activating enzyme (AAE) consensus motif; other site 685727010095 AMP binding site [chemical binding]; other site 685727010096 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 685727010097 Condensation domain; Region: Condensation; pfam00668 685727010098 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 685727010099 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 685727010100 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 685727010101 acyl-activating enzyme (AAE) consensus motif; other site 685727010102 AMP binding site [chemical binding]; other site 685727010103 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 685727010104 Condensation domain; Region: Condensation; pfam00668 685727010105 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 685727010106 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 685727010107 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 685727010108 acyl-activating enzyme (AAE) consensus motif; other site 685727010109 AMP binding site [chemical binding]; other site 685727010110 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 685727010111 Condensation domain; Region: Condensation; pfam00668 685727010112 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 685727010113 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 685727010114 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 685727010115 Transcriptional regulators [Transcription]; Region: FadR; COG2186 685727010116 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 685727010117 DNA-binding site [nucleotide binding]; DNA binding site 685727010118 FCD domain; Region: FCD; pfam07729 685727010119 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 685727010120 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 685727010121 acyl-activating enzyme (AAE) consensus motif; other site 685727010122 putative AMP binding site [chemical binding]; other site 685727010123 putative active site [active] 685727010124 putative CoA binding site [chemical binding]; other site 685727010125 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 685727010126 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 685727010127 putative active site [active] 685727010128 putative catalytic site [active] 685727010129 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 685727010130 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 685727010131 active site 685727010132 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 685727010133 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 685727010134 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 685727010135 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 685727010136 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 685727010137 carboxyltransferase (CT) interaction site; other site 685727010138 biotinylation site [posttranslational modification]; other site 685727010139 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 685727010140 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 685727010141 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727010142 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727010143 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 685727010144 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 685727010145 NAD binding site [chemical binding]; other site 685727010146 catalytic Zn binding site [ion binding]; other site 685727010147 substrate binding site [chemical binding]; other site 685727010148 structural Zn binding site [ion binding]; other site 685727010149 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 685727010150 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 685727010151 NAD(P) binding site [chemical binding]; other site 685727010152 catalytic residues [active] 685727010153 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 685727010154 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 685727010155 AMP-binding domain protein; Validated; Region: PRK08315 685727010156 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 685727010157 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 685727010158 acyl-activating enzyme (AAE) consensus motif; other site 685727010159 putative AMP binding site [chemical binding]; other site 685727010160 putative active site [active] 685727010161 putative CoA binding site [chemical binding]; other site 685727010162 metabolite-proton symporter; Region: 2A0106; TIGR00883 685727010163 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727010164 putative substrate translocation pore; other site 685727010165 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 685727010166 Protein of unknown function (DUF779); Region: DUF779; pfam05610 685727010167 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 685727010168 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 685727010169 NAD binding site [chemical binding]; other site 685727010170 substrate binding site [chemical binding]; other site 685727010171 catalytic Zn binding site [ion binding]; other site 685727010172 tetramer interface [polypeptide binding]; other site 685727010173 structural Zn binding site [ion binding]; other site 685727010174 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 685727010175 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 685727010176 NAD(P) binding site [chemical binding]; other site 685727010177 catalytic residues [active] 685727010178 acyl-CoA synthetase; Validated; Region: PRK07798 685727010179 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 685727010180 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 685727010181 acyl-activating enzyme (AAE) consensus motif; other site 685727010182 putative AMP binding site [chemical binding]; other site 685727010183 putative active site [active] 685727010184 putative CoA binding site [chemical binding]; other site 685727010185 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 685727010186 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 685727010187 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 685727010188 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 685727010189 Probable Catalytic site; other site 685727010190 metal-binding site 685727010191 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 685727010192 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 685727010193 Domain of unknown function (DUF222); Region: DUF222; pfam02720 685727010194 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 685727010195 active site 685727010196 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 685727010197 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 685727010198 phosphate binding site [ion binding]; other site 685727010199 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 685727010200 classical (c) SDRs; Region: SDR_c; cd05233 685727010201 NAD(P) binding site [chemical binding]; other site 685727010202 active site 685727010203 mycofactocin system FadH/OYE family oxidoreductase 1; Region: mycofact_OYE_1; TIGR03996 685727010204 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 685727010205 phosphate binding site [ion binding]; other site 685727010206 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 685727010207 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 685727010208 phosphate binding site [ion binding]; other site 685727010209 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 685727010210 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 685727010211 FeS/SAM binding site; other site 685727010212 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 685727010213 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 685727010214 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 685727010215 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727010216 Methyltransferase domain; Region: Methyltransf_11; pfam08241 685727010217 S-adenosylmethionine binding site [chemical binding]; other site 685727010218 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 685727010219 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 685727010220 FAD binding pocket [chemical binding]; other site 685727010221 FAD binding motif [chemical binding]; other site 685727010222 phosphate binding motif [ion binding]; other site 685727010223 beta-alpha-beta structure motif; other site 685727010224 NAD(p) ribose binding residues [chemical binding]; other site 685727010225 NAD binding pocket [chemical binding]; other site 685727010226 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 685727010227 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 685727010228 catalytic loop [active] 685727010229 iron binding site [ion binding]; other site 685727010230 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727010231 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727010232 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 685727010233 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 685727010234 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 685727010235 Asp23 family; Region: Asp23; pfam03780 685727010236 Asp23 family; Region: Asp23; pfam03780 685727010237 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 685727010238 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 685727010239 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 685727010240 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 685727010241 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 685727010242 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685727010243 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 685727010244 dimerization interface [polypeptide binding]; other site 685727010245 elongation factor Tu; Reviewed; Region: PRK00049 685727010246 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 685727010247 G1 box; other site 685727010248 GEF interaction site [polypeptide binding]; other site 685727010249 GTP/Mg2+ binding site [chemical binding]; other site 685727010250 Switch I region; other site 685727010251 G2 box; other site 685727010252 G3 box; other site 685727010253 Switch II region; other site 685727010254 G4 box; other site 685727010255 G5 box; other site 685727010256 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 685727010257 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 685727010258 Antibiotic Binding Site [chemical binding]; other site 685727010259 elongation factor G; Reviewed; Region: PRK00007 685727010260 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 685727010261 G1 box; other site 685727010262 putative GEF interaction site [polypeptide binding]; other site 685727010263 GTP/Mg2+ binding site [chemical binding]; other site 685727010264 Switch I region; other site 685727010265 G2 box; other site 685727010266 G3 box; other site 685727010267 Switch II region; other site 685727010268 G4 box; other site 685727010269 G5 box; other site 685727010270 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 685727010271 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 685727010272 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 685727010273 30S ribosomal protein S7; Validated; Region: PRK05302 685727010274 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 685727010275 S17 interaction site [polypeptide binding]; other site 685727010276 S8 interaction site; other site 685727010277 16S rRNA interaction site [nucleotide binding]; other site 685727010278 streptomycin interaction site [chemical binding]; other site 685727010279 23S rRNA interaction site [nucleotide binding]; other site 685727010280 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 685727010281 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 685727010282 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 685727010283 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727010284 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727010285 enoyl-CoA hydratase; Provisional; Region: PRK07827 685727010286 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 685727010287 substrate binding site [chemical binding]; other site 685727010288 oxyanion hole (OAH) forming residues; other site 685727010289 trimer interface [polypeptide binding]; other site 685727010290 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 685727010291 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 685727010292 active site 685727010293 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 685727010294 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 685727010295 ATP-grasp domain; Region: ATP-grasp_4; cl17255 685727010296 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 685727010297 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 685727010298 carboxyltransferase (CT) interaction site; other site 685727010299 biotinylation site [posttranslational modification]; other site 685727010300 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 685727010301 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 685727010302 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 685727010303 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 685727010304 active site 685727010305 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 685727010306 TIGR03084 family protein; Region: TIGR03084 685727010307 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 685727010308 Wyosine base formation; Region: Wyosine_form; pfam08608 685727010309 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 685727010310 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727010311 putative substrate translocation pore; other site 685727010312 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727010313 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 685727010314 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 685727010315 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 685727010316 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 685727010317 NAD(P) binding site [chemical binding]; other site 685727010318 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 685727010319 4Fe-4S binding domain; Region: Fer4; pfam00037 685727010320 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 685727010321 ferredoxin-NADP+ reductase; Region: PLN02852 685727010322 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 685727010323 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 685727010324 active site 2 [active] 685727010325 active site 1 [active] 685727010326 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 685727010327 active site 2 [active] 685727010328 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 685727010329 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 685727010330 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 685727010331 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 685727010332 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 685727010333 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 685727010334 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 685727010335 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 685727010336 DNA binding site [nucleotide binding] 685727010337 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 685727010338 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 685727010339 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 685727010340 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 685727010341 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 685727010342 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 685727010343 RPB10 interaction site [polypeptide binding]; other site 685727010344 RPB1 interaction site [polypeptide binding]; other site 685727010345 RPB11 interaction site [polypeptide binding]; other site 685727010346 RPB3 interaction site [polypeptide binding]; other site 685727010347 RPB12 interaction site [polypeptide binding]; other site 685727010348 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 685727010349 mce related protein; Region: MCE; pfam02470 685727010350 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 685727010351 mce related protein; Region: MCE; pfam02470 685727010352 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 685727010353 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 685727010354 mce related protein; Region: MCE; pfam02470 685727010355 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 685727010356 mce related protein; Region: MCE; pfam02470 685727010357 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 685727010358 mce related protein; Region: MCE; pfam02470 685727010359 mce related protein; Region: MCE; pfam02470 685727010360 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 685727010361 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 685727010362 Permease; Region: Permease; pfam02405 685727010363 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 685727010364 Permease; Region: Permease; pfam02405 685727010365 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 685727010366 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 685727010367 Walker A/P-loop; other site 685727010368 ATP binding site [chemical binding]; other site 685727010369 Q-loop/lid; other site 685727010370 ABC transporter signature motif; other site 685727010371 Walker B; other site 685727010372 D-loop; other site 685727010373 H-loop/switch region; other site 685727010374 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 685727010375 core dimer interface [polypeptide binding]; other site 685727010376 peripheral dimer interface [polypeptide binding]; other site 685727010377 L10 interface [polypeptide binding]; other site 685727010378 L11 interface [polypeptide binding]; other site 685727010379 putative EF-Tu interaction site [polypeptide binding]; other site 685727010380 putative EF-G interaction site [polypeptide binding]; other site 685727010381 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 685727010382 23S rRNA interface [nucleotide binding]; other site 685727010383 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 685727010384 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 685727010385 mRNA/rRNA interface [nucleotide binding]; other site 685727010386 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 685727010387 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 685727010388 23S rRNA interface [nucleotide binding]; other site 685727010389 L7/L12 interface [polypeptide binding]; other site 685727010390 putative thiostrepton binding site; other site 685727010391 L25 interface [polypeptide binding]; other site 685727010392 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 685727010393 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 685727010394 putative homodimer interface [polypeptide binding]; other site 685727010395 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 685727010396 heterodimer interface [polypeptide binding]; other site 685727010397 homodimer interface [polypeptide binding]; other site 685727010398 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 685727010399 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 685727010400 active site 685727010401 catalytic site [active] 685727010402 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 685727010403 active site 685727010404 catalytic site [active] 685727010405 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 685727010406 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 685727010407 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 685727010408 NAD binding site [chemical binding]; other site 685727010409 catalytic residues [active] 685727010410 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 685727010411 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 685727010412 heat shock protein HtpX; Provisional; Region: PRK03072 685727010413 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 685727010414 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 685727010415 substrate binding pocket [chemical binding]; other site 685727010416 chain length determination region; other site 685727010417 substrate-Mg2+ binding site; other site 685727010418 catalytic residues [active] 685727010419 aspartate-rich region 1; other site 685727010420 active site lid residues [active] 685727010421 aspartate-rich region 2; other site 685727010422 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 685727010423 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 685727010424 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 685727010425 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685727010426 S-adenosylmethionine binding site [chemical binding]; other site 685727010427 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 685727010428 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 685727010429 active site 685727010430 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 685727010431 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 685727010432 dimer interface [polypeptide binding]; other site 685727010433 tetramer interface [polypeptide binding]; other site 685727010434 PYR/PP interface [polypeptide binding]; other site 685727010435 TPP binding site [chemical binding]; other site 685727010436 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 685727010437 TPP-binding site; other site 685727010438 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 685727010439 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 685727010440 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 685727010441 FAD binding pocket [chemical binding]; other site 685727010442 FAD binding motif [chemical binding]; other site 685727010443 phosphate binding motif [ion binding]; other site 685727010444 NAD binding pocket [chemical binding]; other site 685727010445 O-succinylbenzoate synthase; Provisional; Region: PRK02901 685727010446 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 685727010447 active site 685727010448 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 685727010449 CoenzymeA binding site [chemical binding]; other site 685727010450 subunit interaction site [polypeptide binding]; other site 685727010451 PHB binding site; other site 685727010452 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 685727010453 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 685727010454 substrate binding site [chemical binding]; other site 685727010455 oxyanion hole (OAH) forming residues; other site 685727010456 trimer interface [polypeptide binding]; other site 685727010457 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 685727010458 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 685727010459 DEAD-like helicases superfamily; Region: DEXDc; smart00487 685727010460 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 685727010461 ATP binding site [chemical binding]; other site 685727010462 putative Mg++ binding site [ion binding]; other site 685727010463 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 685727010464 nucleotide binding region [chemical binding]; other site 685727010465 ATP-binding site [chemical binding]; other site 685727010466 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 685727010467 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 685727010468 active site 685727010469 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 685727010470 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 685727010471 Walker A/P-loop; other site 685727010472 ATP binding site [chemical binding]; other site 685727010473 Q-loop/lid; other site 685727010474 ABC transporter signature motif; other site 685727010475 Walker B; other site 685727010476 D-loop; other site 685727010477 H-loop/switch region; other site 685727010478 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 685727010479 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 685727010480 Walker A/P-loop; other site 685727010481 ATP binding site [chemical binding]; other site 685727010482 Q-loop/lid; other site 685727010483 ABC transporter signature motif; other site 685727010484 Walker B; other site 685727010485 D-loop; other site 685727010486 H-loop/switch region; other site 685727010487 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 685727010488 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 685727010489 TM-ABC transporter signature motif; other site 685727010490 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 685727010491 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 685727010492 TM-ABC transporter signature motif; other site 685727010493 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 685727010494 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 685727010495 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 685727010496 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 685727010497 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 685727010498 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 685727010499 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 685727010500 acyl-activating enzyme (AAE) consensus motif; other site 685727010501 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 685727010502 AMP binding site [chemical binding]; other site 685727010503 active site 685727010504 acyl-activating enzyme (AAE) consensus motif; other site 685727010505 CoA binding site [chemical binding]; other site 685727010506 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685727010507 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 685727010508 Walker A/P-loop; other site 685727010509 ATP binding site [chemical binding]; other site 685727010510 Q-loop/lid; other site 685727010511 ABC transporter signature motif; other site 685727010512 Walker B; other site 685727010513 D-loop; other site 685727010514 H-loop/switch region; other site 685727010515 ABC-2 type transporter; Region: ABC2_membrane; cl17235 685727010516 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 685727010517 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 685727010518 Bacterial transcriptional activator domain; Region: BTAD; smart01043 685727010519 Predicted ATPase [General function prediction only]; Region: COG3903 685727010520 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 685727010521 UbiA prenyltransferase family; Region: UbiA; pfam01040 685727010522 Membrane protein of unknown function; Region: DUF360; pfam04020 685727010523 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217 685727010524 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 685727010525 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 685727010526 putative acyl-acceptor binding pocket; other site 685727010527 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 685727010528 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 685727010529 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 685727010530 classical (c) SDRs; Region: SDR_c; cd05233 685727010531 NAD(P) binding site [chemical binding]; other site 685727010532 active site 685727010533 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 685727010534 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 685727010535 Coenzyme A binding pocket [chemical binding]; other site 685727010536 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 685727010537 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 685727010538 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 685727010539 catalytic residue [active] 685727010540 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 685727010541 DNA binding residues [nucleotide binding] 685727010542 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 685727010543 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 685727010544 ResB-like family; Region: ResB; pfam05140 685727010545 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 685727010546 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 685727010547 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 685727010548 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 685727010549 catalytic residues [active] 685727010550 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 685727010551 catalytic core [active] 685727010552 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 685727010553 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 685727010554 inhibitor-cofactor binding pocket; inhibition site 685727010555 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685727010556 catalytic residue [active] 685727010557 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 685727010558 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 685727010559 active site 685727010560 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 685727010561 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685727010562 S-adenosylmethionine binding site [chemical binding]; other site 685727010563 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 685727010564 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 685727010565 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 685727010566 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 685727010567 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 685727010568 metal-binding site [ion binding] 685727010569 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 685727010570 Soluble P-type ATPase [General function prediction only]; Region: COG4087 685727010571 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 685727010572 metal-binding site [ion binding] 685727010573 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 685727010574 putative homodimer interface [polypeptide binding]; other site 685727010575 putative homotetramer interface [polypeptide binding]; other site 685727010576 putative allosteric switch controlling residues; other site 685727010577 putative metal binding site [ion binding]; other site 685727010578 putative homodimer-homodimer interface [polypeptide binding]; other site 685727010579 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 685727010580 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 685727010581 dimer interface [polypeptide binding]; other site 685727010582 active site 685727010583 Schiff base residues; other site 685727010584 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 685727010585 active site 685727010586 homodimer interface [polypeptide binding]; other site 685727010587 SAM binding site [chemical binding]; other site 685727010588 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 685727010589 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 685727010590 active site 685727010591 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 685727010592 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 685727010593 domain interfaces; other site 685727010594 active site 685727010595 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 685727010596 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 685727010597 tRNA; other site 685727010598 putative tRNA binding site [nucleotide binding]; other site 685727010599 putative NADP binding site [chemical binding]; other site 685727010600 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 685727010601 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 685727010602 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 685727010603 CoA binding domain; Region: CoA_binding; smart00881 685727010604 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 685727010605 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 685727010606 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 685727010607 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 685727010608 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 685727010609 putative acyl-acceptor binding pocket; other site 685727010610 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 685727010611 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727010612 NAD(P) binding site [chemical binding]; other site 685727010613 active site 685727010614 DNA binding domain, excisionase family; Region: excise; TIGR01764 685727010615 CAAX protease self-immunity; Region: Abi; pfam02517 685727010616 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 685727010617 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 685727010618 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 685727010619 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 685727010620 active site 2 [active] 685727010621 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 685727010622 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 685727010623 DNA binding residues [nucleotide binding] 685727010624 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 685727010625 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 685727010626 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 685727010627 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 685727010628 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 685727010629 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685727010630 active site 685727010631 phosphorylation site [posttranslational modification] 685727010632 intermolecular recognition site; other site 685727010633 dimerization interface [polypeptide binding]; other site 685727010634 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 685727010635 DNA binding site [nucleotide binding] 685727010636 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 685727010637 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 685727010638 dimer interface [polypeptide binding]; other site 685727010639 phosphorylation site [posttranslational modification] 685727010640 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685727010641 ATP binding site [chemical binding]; other site 685727010642 Mg2+ binding site [ion binding]; other site 685727010643 G-X-G motif; other site 685727010644 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 685727010645 catalytic core [active] 685727010646 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 685727010647 Uncharacterized conserved protein [Function unknown]; Region: COG1359 685727010648 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 685727010649 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 685727010650 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 685727010651 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 685727010652 putative ADP-binding pocket [chemical binding]; other site 685727010653 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 685727010654 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 685727010655 TAP-like protein; Region: Abhydrolase_4; pfam08386 685727010656 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 685727010657 Tocopherol cyclase; Region: Tocopherol_cycl; cl14571 685727010658 Secretory lipase; Region: LIP; pfam03583 685727010659 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 685727010660 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 685727010661 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 685727010662 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727010663 NAD(P) binding site [chemical binding]; other site 685727010664 active site 685727010665 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 685727010666 Proteins of 100 residues with WXG; Region: WXG100; cl02005 685727010667 EspG family; Region: ESX-1_EspG; pfam14011 685727010668 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 685727010669 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 685727010670 Serine hydrolase; Region: Ser_hydrolase; cl17834 685727010671 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 685727010672 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 685727010673 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 685727010674 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 685727010675 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 685727010676 FAD binding domain; Region: FAD_binding_4; pfam01565 685727010677 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 685727010678 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 685727010679 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 685727010680 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 685727010681 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 685727010682 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 685727010683 intersubunit interface [polypeptide binding]; other site 685727010684 active site 685727010685 catalytic residue [active] 685727010686 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685727010687 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 685727010688 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 685727010689 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 685727010690 putative active site [active] 685727010691 putative substrate binding site [chemical binding]; other site 685727010692 putative cosubstrate binding site; other site 685727010693 catalytic site [active] 685727010694 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 685727010695 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 685727010696 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778 685727010697 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 685727010698 DNA binding residues [nucleotide binding] 685727010699 putative dimer interface [polypeptide binding]; other site 685727010700 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 685727010701 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 685727010702 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 685727010703 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 685727010704 non-specific DNA binding site [nucleotide binding]; other site 685727010705 salt bridge; other site 685727010706 sequence-specific DNA binding site [nucleotide binding]; other site 685727010707 Predicted membrane protein [Function unknown]; Region: COG2733 685727010708 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727010709 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727010710 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 685727010711 ABC1 family; Region: ABC1; pfam03109 685727010712 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 685727010713 active site 685727010714 ATP binding site [chemical binding]; other site 685727010715 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 685727010716 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 685727010717 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 685727010718 putative NAD(P) binding site [chemical binding]; other site 685727010719 putative substrate binding site [chemical binding]; other site 685727010720 catalytic Zn binding site [ion binding]; other site 685727010721 structural Zn binding site [ion binding]; other site 685727010722 dimer interface [polypeptide binding]; other site 685727010723 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 685727010724 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 685727010725 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 685727010726 THF binding site; other site 685727010727 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 685727010728 substrate binding site [chemical binding]; other site 685727010729 THF binding site; other site 685727010730 zinc-binding site [ion binding]; other site 685727010731 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 685727010732 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 685727010733 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 685727010734 isocitrate lyase; Provisional; Region: PRK15063 685727010735 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 685727010736 tetramer interface [polypeptide binding]; other site 685727010737 active site 685727010738 Mg2+/Mn2+ binding site [ion binding]; other site 685727010739 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 685727010740 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 685727010741 non-specific DNA binding site [nucleotide binding]; other site 685727010742 salt bridge; other site 685727010743 sequence-specific DNA binding site [nucleotide binding]; other site 685727010744 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 685727010745 Domain of unknown function (DUF955); Region: DUF955; pfam06114 685727010746 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 685727010747 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 685727010748 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 685727010749 putative ligand binding site [chemical binding]; other site 685727010750 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 685727010751 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 685727010752 TM-ABC transporter signature motif; other site 685727010753 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 685727010754 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 685727010755 TM-ABC transporter signature motif; other site 685727010756 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 685727010757 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 685727010758 Walker A/P-loop; other site 685727010759 ATP binding site [chemical binding]; other site 685727010760 Q-loop/lid; other site 685727010761 ABC transporter signature motif; other site 685727010762 Walker B; other site 685727010763 D-loop; other site 685727010764 H-loop/switch region; other site 685727010765 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 685727010766 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 685727010767 Walker A/P-loop; other site 685727010768 ATP binding site [chemical binding]; other site 685727010769 Q-loop/lid; other site 685727010770 ABC transporter signature motif; other site 685727010771 Walker B; other site 685727010772 D-loop; other site 685727010773 H-loop/switch region; other site 685727010774 urea carboxylase; Region: urea_carbox; TIGR02712 685727010775 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 685727010776 ATP-grasp domain; Region: ATP-grasp_4; cl17255 685727010777 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 685727010778 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 685727010779 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 685727010780 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 685727010781 carboxyltransferase (CT) interaction site; other site 685727010782 biotinylation site [posttranslational modification]; other site 685727010783 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 685727010784 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 685727010785 acyl-activating enzyme (AAE) consensus motif; other site 685727010786 active site 685727010787 AMP binding site [chemical binding]; other site 685727010788 CoA binding site [chemical binding]; other site 685727010789 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 685727010790 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 685727010791 Walker A/P-loop; other site 685727010792 ATP binding site [chemical binding]; other site 685727010793 Q-loop/lid; other site 685727010794 ABC transporter signature motif; other site 685727010795 Walker B; other site 685727010796 D-loop; other site 685727010797 H-loop/switch region; other site 685727010798 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 685727010799 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 685727010800 Walker A/P-loop; other site 685727010801 ATP binding site [chemical binding]; other site 685727010802 Q-loop/lid; other site 685727010803 ABC transporter signature motif; other site 685727010804 Walker B; other site 685727010805 D-loop; other site 685727010806 H-loop/switch region; other site 685727010807 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 685727010808 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 685727010809 TM-ABC transporter signature motif; other site 685727010810 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 685727010811 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 685727010812 TM-ABC transporter signature motif; other site 685727010813 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 685727010814 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 685727010815 ligand binding site [chemical binding]; other site 685727010816 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727010817 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727010818 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 685727010819 classical (c) SDRs; Region: SDR_c; cd05233 685727010820 NAD(P) binding site [chemical binding]; other site 685727010821 active site 685727010822 Uncharacterized conserved protein [Function unknown]; Region: COG2128 685727010823 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 685727010824 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 685727010825 synthetase active site [active] 685727010826 NTP binding site [chemical binding]; other site 685727010827 metal binding site [ion binding]; metal-binding site 685727010828 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727010829 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 685727010830 putative substrate translocation pore; other site 685727010831 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727010832 NmrA-like family; Region: NmrA; pfam05368 685727010833 NAD(P) binding site [chemical binding]; other site 685727010834 active site 685727010835 Predicted transcriptional regulators [Transcription]; Region: COG1733 685727010836 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 685727010837 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 685727010838 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 685727010839 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 685727010840 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 685727010841 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 685727010842 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 685727010843 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 685727010844 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 685727010845 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 685727010846 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 685727010847 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 685727010848 Putative esterase; Region: Esterase; pfam00756 685727010849 S-formylglutathione hydrolase; Region: PLN02442 685727010850 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 685727010851 PspC domain; Region: PspC; pfam04024 685727010852 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 685727010853 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 685727010854 ring oligomerisation interface [polypeptide binding]; other site 685727010855 ATP/Mg binding site [chemical binding]; other site 685727010856 stacking interactions; other site 685727010857 hinge regions; other site 685727010858 Haloacid Dehalogenase Superfamily Class (subfamily) IIA; Region: HAD-SF-IIA; TIGR01460 685727010859 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685727010860 active site 685727010861 motif I; other site 685727010862 motif II; other site 685727010863 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685727010864 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 685727010865 hydrophobic ligand binding site; other site 685727010866 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 685727010867 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 685727010868 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 685727010869 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 685727010870 putative active site [active] 685727010871 Cell division protein 48 (CDC48) N-terminal domain; Region: CDC48_N; smart01073 685727010872 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 685727010873 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 685727010874 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685727010875 Walker A motif; other site 685727010876 ATP binding site [chemical binding]; other site 685727010877 Walker B motif; other site 685727010878 arginine finger; other site 685727010879 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685727010880 Walker A motif; other site 685727010881 ATP binding site [chemical binding]; other site 685727010882 Walker B motif; other site 685727010883 arginine finger; other site 685727010884 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 685727010885 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 685727010886 tetramer interface [polypeptide binding]; other site 685727010887 active site 685727010888 Mg2+/Mn2+ binding site [ion binding]; other site 685727010889 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727010890 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727010891 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727010892 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727010893 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 685727010894 nudix motif; other site 685727010895 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 685727010896 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 685727010897 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 685727010898 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 685727010899 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 685727010900 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 685727010901 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 685727010902 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK07948 685727010903 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 685727010904 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 685727010905 active site 685727010906 carboxylate-amine ligase; Provisional; Region: PRK13517 685727010907 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 685727010908 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 685727010909 E-class dimer interface [polypeptide binding]; other site 685727010910 P-class dimer interface [polypeptide binding]; other site 685727010911 active site 685727010912 Cu2+ binding site [ion binding]; other site 685727010913 Zn2+ binding site [ion binding]; other site 685727010914 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 685727010915 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 685727010916 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 685727010917 active site 685727010918 catalytic residues [active] 685727010919 metal binding site [ion binding]; metal-binding site 685727010920 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 685727010921 putative catalytic site [active] 685727010922 putative phosphate binding site [ion binding]; other site 685727010923 active site 685727010924 metal binding site A [ion binding]; metal-binding site 685727010925 DNA binding site [nucleotide binding] 685727010926 putative AP binding site [nucleotide binding]; other site 685727010927 putative metal binding site B [ion binding]; other site 685727010928 Predicted acetyltransferase [General function prediction only]; Region: COG2388 685727010929 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 685727010930 dimer interface [polypeptide binding]; other site 685727010931 substrate binding site [chemical binding]; other site 685727010932 ATP binding site [chemical binding]; other site 685727010933 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 685727010934 cyclase homology domain; Region: CHD; cd07302 685727010935 nucleotidyl binding site; other site 685727010936 metal binding site [ion binding]; metal-binding site 685727010937 dimer interface [polypeptide binding]; other site 685727010938 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 685727010939 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 685727010940 PA/protease or protease-like domain interface [polypeptide binding]; other site 685727010941 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 685727010942 Peptidase family M28; Region: Peptidase_M28; pfam04389 685727010943 active site 685727010944 metal binding site [ion binding]; metal-binding site 685727010945 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 685727010946 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 685727010947 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 685727010948 conserved cys residue [active] 685727010949 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685727010950 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 685727010951 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 685727010952 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 685727010953 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 685727010954 Walker A/P-loop; other site 685727010955 ATP binding site [chemical binding]; other site 685727010956 Q-loop/lid; other site 685727010957 ABC transporter signature motif; other site 685727010958 Walker B; other site 685727010959 D-loop; other site 685727010960 H-loop/switch region; other site 685727010961 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 685727010962 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 685727010963 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 685727010964 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 685727010965 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 685727010966 ThiS interaction site; other site 685727010967 putative active site [active] 685727010968 tetramer interface [polypeptide binding]; other site 685727010969 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 685727010970 thiS-thiF/thiG interaction site; other site 685727010971 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 685727010972 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 685727010973 thiamine phosphate binding site [chemical binding]; other site 685727010974 active site 685727010975 pyrophosphate binding site [ion binding]; other site 685727010976 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 685727010977 Predicted transcriptional regulators [Transcription]; Region: COG1733 685727010978 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 685727010979 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727010980 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 685727010981 putative substrate translocation pore; other site 685727010982 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 685727010983 NUDIX domain; Region: NUDIX; pfam00293 685727010984 nudix motif; other site 685727010985 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 685727010986 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 685727010987 substrate binding pocket [chemical binding]; other site 685727010988 membrane-bound complex binding site; other site 685727010989 hinge residues; other site 685727010990 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 685727010991 Catalytic domain of Protein Kinases; Region: PKc; cd00180 685727010992 active site 685727010993 ATP binding site [chemical binding]; other site 685727010994 substrate binding site [chemical binding]; other site 685727010995 activation loop (A-loop); other site 685727010996 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 685727010997 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 685727010998 D-pathway; other site 685727010999 Putative ubiquinol binding site [chemical binding]; other site 685727011000 Low-spin heme (heme b) binding site [chemical binding]; other site 685727011001 Putative water exit pathway; other site 685727011002 Binuclear center (heme o3/CuB) [ion binding]; other site 685727011003 K-pathway; other site 685727011004 Putative proton exit pathway; other site 685727011005 propionate/acetate kinase; Provisional; Region: PRK12379 685727011006 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 685727011007 phosphate acetyltransferase; Reviewed; Region: PRK05632 685727011008 DRTGG domain; Region: DRTGG; pfam07085 685727011009 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 685727011010 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 685727011011 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 685727011012 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 685727011013 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 685727011014 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 685727011015 RDD family; Region: RDD; pfam06271 685727011016 Predicted esterase [General function prediction only]; Region: COG0627 685727011017 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 685727011018 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685727011019 active site 685727011020 motif I; other site 685727011021 motif II; other site 685727011022 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 685727011023 motif II; other site 685727011024 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 685727011025 Beta-lactamase; Region: Beta-lactamase; pfam00144 685727011026 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 685727011027 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 685727011028 homotrimer interface [polypeptide binding]; other site 685727011029 Walker A motif; other site 685727011030 GTP binding site [chemical binding]; other site 685727011031 Walker B motif; other site 685727011032 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 685727011033 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 685727011034 homodimer interface [polypeptide binding]; other site 685727011035 substrate-cofactor binding pocket; other site 685727011036 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685727011037 catalytic residue [active] 685727011038 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 685727011039 active site residue [active] 685727011040 ferredoxin-NADP+ reductase; Region: PLN02852 685727011041 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 685727011042 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 685727011043 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 685727011044 active site 685727011045 Protein of unknown function (DUF456); Region: DUF456; pfam04306 685727011046 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 685727011047 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 685727011048 NAD binding site [chemical binding]; other site 685727011049 ATP-grasp domain; Region: ATP-grasp; pfam02222 685727011050 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 685727011051 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 685727011052 catalytic site [active] 685727011053 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 685727011054 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 685727011055 active site 685727011056 putative CoA-transferase; Provisional; Region: PRK11430 685727011057 CoA-transferase family III; Region: CoA_transf_3; pfam02515 685727011058 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 685727011059 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 685727011060 DNA-binding site [nucleotide binding]; DNA binding site 685727011061 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 685727011062 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685727011063 homodimer interface [polypeptide binding]; other site 685727011064 catalytic residue [active] 685727011065 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 685727011066 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 685727011067 DNA binding residues [nucleotide binding] 685727011068 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 685727011069 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 685727011070 NAD binding site [chemical binding]; other site 685727011071 catalytic Zn binding site [ion binding]; other site 685727011072 substrate binding site [chemical binding]; other site 685727011073 structural Zn binding site [ion binding]; other site 685727011074 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 685727011075 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 685727011076 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 685727011077 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 685727011078 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 685727011079 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 685727011080 active site 685727011081 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 685727011082 domain_subunit interface; other site 685727011083 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 685727011084 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 685727011085 active site 685727011086 FMN binding site [chemical binding]; other site 685727011087 substrate binding site [chemical binding]; other site 685727011088 3Fe-4S cluster binding site [ion binding]; other site 685727011089 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 685727011090 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 685727011091 non-specific DNA binding site [nucleotide binding]; other site 685727011092 salt bridge; other site 685727011093 sequence-specific DNA binding site [nucleotide binding]; other site 685727011094 Cupin domain; Region: Cupin_2; pfam07883 685727011095 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 685727011096 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 685727011097 siderophore binding site; other site 685727011098 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 685727011099 putative switch regulator; other site 685727011100 non-specific DNA interactions [nucleotide binding]; other site 685727011101 DNA binding site [nucleotide binding] 685727011102 sequence specific DNA binding site [nucleotide binding]; other site 685727011103 putative cAMP binding site [chemical binding]; other site 685727011104 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 685727011105 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 685727011106 hydroxyglutarate oxidase; Provisional; Region: PRK11728 685727011107 glycogen branching enzyme; Provisional; Region: PRK14705 685727011108 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 685727011109 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 685727011110 GDP-binding site [chemical binding]; other site 685727011111 ACT binding site; other site 685727011112 IMP binding site; other site 685727011113 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 685727011114 Peptidase family M50; Region: Peptidase_M50; pfam02163 685727011115 active site 685727011116 putative substrate binding region [chemical binding]; other site 685727011117 Chorismate mutase type II; Region: CM_2; cl00693 685727011118 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 685727011119 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 685727011120 homodimer interface [polypeptide binding]; other site 685727011121 substrate-cofactor binding pocket; other site 685727011122 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685727011123 catalytic residue [active] 685727011124 HTH domain; Region: HTH_11; pfam08279 685727011125 WYL domain; Region: WYL; pfam13280 685727011126 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 685727011127 short chain dehydrogenase; Provisional; Region: PRK08303 685727011128 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727011129 NAD(P) binding site [chemical binding]; other site 685727011130 active site 685727011131 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 685727011132 Predicted membrane protein [Function unknown]; Region: COG4129 685727011133 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 685727011134 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 685727011135 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 685727011136 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 685727011137 active site 685727011138 intersubunit interface [polypeptide binding]; other site 685727011139 zinc binding site [ion binding]; other site 685727011140 Na+ binding site [ion binding]; other site 685727011141 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 685727011142 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 685727011143 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 685727011144 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 685727011146 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 685727011147 short chain dehydrogenase; Provisional; Region: PRK08267 685727011148 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727011149 NAD(P) binding site [chemical binding]; other site 685727011150 active site 685727011151 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 685727011152 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727011153 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727011154 YhhN-like protein; Region: YhhN; cl01505 685727011155 MarR family; Region: MarR; pfam01047 685727011156 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727011157 Major Facilitator Superfamily; Region: MFS_1; pfam07690 685727011158 putative substrate translocation pore; other site 685727011159 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 685727011160 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 685727011161 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 685727011162 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 685727011163 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 685727011164 dimer interface [polypeptide binding]; other site 685727011165 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 685727011166 active site 685727011167 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 685727011168 active site 685727011169 LemA family; Region: LemA; cl00742 685727011170 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 685727011171 RNA binding surface [nucleotide binding]; other site 685727011172 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 685727011173 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 685727011174 Uncharacterized conserved protein [Function unknown]; Region: COG5649 685727011175 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 685727011176 Lipase (class 2); Region: Lipase_2; pfam01674 685727011177 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 685727011178 Clp amino terminal domain; Region: Clp_N; pfam02861 685727011179 Clp amino terminal domain; Region: Clp_N; pfam02861 685727011180 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685727011181 Walker A motif; other site 685727011182 ATP binding site [chemical binding]; other site 685727011183 Walker B motif; other site 685727011184 arginine finger; other site 685727011185 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 685727011186 Walker A motif; other site 685727011187 ATP binding site [chemical binding]; other site 685727011188 Walker B motif; other site 685727011189 arginine finger; other site 685727011190 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 685727011191 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 685727011192 heme-binding site [chemical binding]; other site 685727011193 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 685727011194 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 685727011195 FAD binding pocket [chemical binding]; other site 685727011196 FAD binding motif [chemical binding]; other site 685727011197 phosphate binding motif [ion binding]; other site 685727011198 beta-alpha-beta structure motif; other site 685727011199 NAD binding pocket [chemical binding]; other site 685727011200 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 685727011201 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 685727011202 ligand binding site [chemical binding]; other site 685727011203 SnoaL-like domain; Region: SnoaL_4; pfam13577 685727011204 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 685727011205 NmrA-like family; Region: NmrA; pfam05368 685727011206 NADP binding site [chemical binding]; other site 685727011207 active site 685727011208 regulatory binding site [polypeptide binding]; other site 685727011209 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 685727011210 FMN reductase; Validated; Region: fre; PRK08051 685727011211 FAD binding pocket [chemical binding]; other site 685727011212 conserved FAD binding motif [chemical binding]; other site 685727011213 phosphate binding motif [ion binding]; other site 685727011214 beta-alpha-beta structure motif; other site 685727011215 NAD binding pocket [chemical binding]; other site 685727011216 acyl-CoA synthetase; Validated; Region: PRK06188 685727011217 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 685727011218 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 685727011219 acyl-activating enzyme (AAE) consensus motif; other site 685727011220 putative AMP binding site [chemical binding]; other site 685727011221 putative active site [active] 685727011222 putative CoA binding site [chemical binding]; other site 685727011223 hypothetical protein; Provisional; Region: PRK06194 685727011224 classical (c) SDRs; Region: SDR_c; cd05233 685727011225 NAD(P) binding site [chemical binding]; other site 685727011226 active site 685727011227 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 685727011228 classical (c) SDRs; Region: SDR_c; cd05233 685727011229 NAD(P) binding site [chemical binding]; other site 685727011230 active site 685727011231 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 685727011232 classical (c) SDRs; Region: SDR_c; cd05233 685727011233 NAD(P) binding site [chemical binding]; other site 685727011234 active site 685727011235 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 685727011236 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 685727011237 Fimbrial protein; Region: Fimbrial; cl01416 685727011238 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 685727011239 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 685727011240 active site 685727011241 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 685727011242 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 685727011243 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 685727011244 active site 685727011245 Fe binding site [ion binding]; other site 685727011246 Transcriptional regulator [Transcription]; Region: IclR; COG1414 685727011247 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 685727011248 Bacterial transcriptional regulator; Region: IclR; pfam01614 685727011249 Predicted transcriptional regulators [Transcription]; Region: COG1695 685727011250 Transcriptional regulator PadR-like family; Region: PadR; cl17335 685727011251 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 685727011252 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 685727011253 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 685727011254 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 685727011255 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 685727011256 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 685727011257 Walker A/P-loop; other site 685727011258 ATP binding site [chemical binding]; other site 685727011259 Q-loop/lid; other site 685727011260 ABC transporter signature motif; other site 685727011261 Walker B; other site 685727011262 D-loop; other site 685727011263 H-loop/switch region; other site 685727011264 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 685727011265 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 685727011266 TM-ABC transporter signature motif; other site 685727011267 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 685727011268 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 685727011269 Walker A/P-loop; other site 685727011270 ATP binding site [chemical binding]; other site 685727011271 Q-loop/lid; other site 685727011272 ABC transporter signature motif; other site 685727011273 Walker B; other site 685727011274 D-loop; other site 685727011275 H-loop/switch region; other site 685727011276 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 685727011277 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 685727011278 TM-ABC transporter signature motif; other site 685727011279 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 685727011280 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 685727011281 ligand binding site [chemical binding]; other site 685727011282 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 685727011283 putative active site [active] 685727011284 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 685727011285 DNA binding residues [nucleotide binding] 685727011286 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 685727011287 putative dimer interface [polypeptide binding]; other site 685727011288 chaperone protein DnaJ; Provisional; Region: PRK14279 685727011289 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 685727011290 HSP70 interaction site [polypeptide binding]; other site 685727011291 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 685727011292 Zn binding sites [ion binding]; other site 685727011293 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 685727011294 dimer interface [polypeptide binding]; other site 685727011295 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 685727011296 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 685727011297 dimer interface [polypeptide binding]; other site 685727011298 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 685727011299 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 685727011300 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 685727011301 nucleotide binding site [chemical binding]; other site 685727011302 NEF interaction site [polypeptide binding]; other site 685727011303 SBD interface [polypeptide binding]; other site 685727011304 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 685727011305 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 685727011306 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 685727011307 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685727011308 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 685727011309 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 685727011310 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 685727011311 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 685727011312 G1 box; other site 685727011313 GTP/Mg2+ binding site [chemical binding]; other site 685727011314 G2 box; other site 685727011315 Switch I region; other site 685727011316 G3 box; other site 685727011317 Switch II region; other site 685727011318 G4 box; other site 685727011319 G5 box; other site 685727011320 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 685727011321 G1 box; other site 685727011322 GTP/Mg2+ binding site [chemical binding]; other site 685727011323 G2 box; other site 685727011324 Switch I region; other site 685727011325 G3 box; other site 685727011326 Switch II region; other site 685727011327 G4 box; other site 685727011328 G5 box; other site 685727011329 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 685727011330 putative NEF/HSP70 interaction site [polypeptide binding]; other site 685727011331 nucleotide binding site [chemical binding]; other site 685727011332 SBD interface [polypeptide binding]; other site 685727011333 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 685727011334 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 685727011335 DNA binding residues [nucleotide binding] 685727011336 dimerization interface [polypeptide binding]; other site 685727011337 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 685727011338 Heterodisulfide reductase, subunit C [Energy production and conversion]; Region: HdrC; COG1150 685727011339 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 685727011340 Cysteine-rich domain; Region: CCG; pfam02754 685727011341 Cysteine-rich domain; Region: CCG; pfam02754 685727011342 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 685727011343 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 685727011344 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 685727011345 aminotransferase AlaT; Validated; Region: PRK09265 685727011346 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 685727011347 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685727011348 homodimer interface [polypeptide binding]; other site 685727011349 catalytic residue [active] 685727011350 YibE/F-like protein; Region: YibE_F; pfam07907 685727011351 Low molecular weight phosphatase family; Region: LMWPc; cd00115 685727011352 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 685727011353 active site 685727011354 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 685727011355 Chain length determinant protein; Region: Wzz; cl15801 685727011356 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 685727011357 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 685727011358 Condensation domain; Region: Condensation; pfam00668 685727011359 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 685727011360 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 685727011361 acyl-activating enzyme (AAE) consensus motif; other site 685727011362 AMP binding site [chemical binding]; other site 685727011363 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 685727011364 Condensation domain; Region: Condensation; pfam00668 685727011365 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 685727011366 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 685727011367 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 685727011368 acyl-activating enzyme (AAE) consensus motif; other site 685727011369 AMP binding site [chemical binding]; other site 685727011370 Condensation domain; Region: Condensation; pfam00668 685727011371 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 685727011372 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 685727011373 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 685727011374 acyl-activating enzyme (AAE) consensus motif; other site 685727011375 AMP binding site [chemical binding]; other site 685727011376 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 685727011377 Condensation domain; Region: Condensation; pfam00668 685727011378 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 685727011379 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 685727011380 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 685727011381 acyl-activating enzyme (AAE) consensus motif; other site 685727011382 AMP binding site [chemical binding]; other site 685727011383 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 685727011384 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 685727011385 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 685727011386 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 685727011387 acyl-activating enzyme (AAE) consensus motif; other site 685727011388 AMP binding site [chemical binding]; other site 685727011389 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 685727011390 Condensation domain; Region: Condensation; pfam00668 685727011391 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 685727011392 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 685727011393 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 685727011394 acyl-activating enzyme (AAE) consensus motif; other site 685727011395 AMP binding site [chemical binding]; other site 685727011396 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 685727011397 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 685727011398 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 685727011399 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 685727011400 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 685727011401 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 685727011402 active site 685727011403 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 685727011404 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 685727011405 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 685727011406 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 685727011407 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 685727011408 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 685727011409 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 685727011410 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 685727011411 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 685727011412 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 685727011413 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 685727011414 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 685727011415 Bacterial sugar transferase; Region: Bac_transf; pfam02397 685727011416 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 685727011417 trimer interface [polypeptide binding]; other site 685727011418 active site 685727011419 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727011420 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727011421 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 685727011422 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 685727011423 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 685727011424 active site 685727011425 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 685727011426 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 685727011427 Walker A/P-loop; other site 685727011428 ATP binding site [chemical binding]; other site 685727011429 Q-loop/lid; other site 685727011430 ABC transporter signature motif; other site 685727011431 Walker B; other site 685727011432 D-loop; other site 685727011433 H-loop/switch region; other site 685727011434 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 685727011435 NMT1-like family; Region: NMT1_2; pfam13379 685727011436 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 685727011437 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685727011438 dimer interface [polypeptide binding]; other site 685727011439 conserved gate region; other site 685727011440 putative PBP binding loops; other site 685727011441 ABC-ATPase subunit interface; other site 685727011442 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 685727011443 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 685727011444 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 685727011445 Excalibur calcium-binding domain; Region: Excalibur; smart00894 685727011446 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 685727011447 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 685727011448 active site 685727011449 catalytic tetrad [active] 685727011450 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 685727011451 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 685727011452 dimer interface [polypeptide binding]; other site 685727011453 active site 685727011454 CoA binding pocket [chemical binding]; other site 685727011455 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 685727011456 SnoaL-like domain; Region: SnoaL_4; pfam13577 685727011457 SnoaL-like domain; Region: SnoaL_3; pfam13474 685727011458 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685727011459 S-adenosylmethionine binding site [chemical binding]; other site 685727011460 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 685727011461 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 685727011462 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 685727011463 FAD binding site [chemical binding]; other site 685727011464 substrate binding site [chemical binding]; other site 685727011465 catalytic residues [active] 685727011466 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 685727011467 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 685727011468 Predicted membrane protein [Function unknown]; Region: COG1511 685727011469 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 685727011470 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 685727011471 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 685727011472 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 685727011473 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 685727011474 VanW like protein; Region: VanW; pfam04294 685727011475 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 685727011476 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 685727011477 dimer interface [polypeptide binding]; other site 685727011478 active site 685727011479 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 685727011480 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727011481 NAD(P) binding site [chemical binding]; other site 685727011482 active site 685727011483 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 685727011484 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 685727011485 active site 2 [active] 685727011486 active site 1 [active] 685727011487 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 685727011488 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 685727011489 DNA binding residues [nucleotide binding] 685727011490 Transcription factor WhiB; Region: Whib; pfam02467 685727011491 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727011492 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727011493 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 685727011494 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 685727011495 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 685727011496 Ligand Binding Site [chemical binding]; other site 685727011497 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 685727011498 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 685727011499 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 685727011500 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 685727011501 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 685727011502 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 685727011503 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685727011504 S-adenosylmethionine binding site [chemical binding]; other site 685727011505 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 685727011506 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 685727011507 nucleotide binding site [chemical binding]; other site 685727011508 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 685727011509 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 685727011510 NAD binding site [chemical binding]; other site 685727011511 catalytic residues [active] 685727011512 Cation efflux family; Region: Cation_efflux; pfam01545 685727011513 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 685727011514 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 685727011515 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727011516 NAD(P) binding site [chemical binding]; other site 685727011517 active site 685727011518 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 685727011519 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 685727011520 trimer interface [polypeptide binding]; other site 685727011521 active site 685727011522 substrate binding site [chemical binding]; other site 685727011523 CoA binding site [chemical binding]; other site 685727011524 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 685727011525 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 685727011526 dimer interface [polypeptide binding]; other site 685727011527 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685727011528 catalytic residue [active] 685727011529 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 685727011530 active site 685727011531 substrate-binding site [chemical binding]; other site 685727011532 metal-binding site [ion binding] 685727011533 GTP binding site [chemical binding]; other site 685727011534 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 685727011535 LabA_like proteins; Region: LabA_like; cd06167 685727011536 putative metal binding site [ion binding]; other site 685727011537 MMPL family; Region: MMPL; pfam03176 685727011538 MMPL family; Region: MMPL; pfam03176 685727011539 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 685727011540 Domain of unknown function DUF20; Region: UPF0118; pfam01594 685727011541 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 685727011542 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 685727011543 dimerization interface [polypeptide binding]; other site 685727011544 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 685727011545 cyclase homology domain; Region: CHD; cd07302 685727011546 nucleotidyl binding site; other site 685727011547 metal binding site [ion binding]; metal-binding site 685727011548 dimer interface [polypeptide binding]; other site 685727011549 Predicted integral membrane protein [Function unknown]; Region: COG0392 685727011550 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 685727011551 DNA-binding site [nucleotide binding]; DNA binding site 685727011552 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 685727011553 FCD domain; Region: FCD; pfam07729 685727011554 2-isopropylmalate synthase; Validated; Region: PRK03739 685727011555 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 685727011556 active site 685727011557 catalytic residues [active] 685727011558 metal binding site [ion binding]; metal-binding site 685727011559 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 685727011560 YceI-like domain; Region: YceI; smart00867 685727011561 hypothetical protein; Provisional; Region: PRK06834 685727011562 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 685727011563 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 685727011564 DoxX-like family; Region: DoxX_2; pfam13564 685727011565 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 685727011566 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 685727011567 POT family; Region: PTR2; cl17359 685727011568 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 685727011569 catalytic core [active] 685727011570 short chain dehydrogenase; Provisional; Region: PRK07454 685727011571 classical (c) SDRs; Region: SDR_c; cd05233 685727011572 NAD(P) binding site [chemical binding]; other site 685727011573 active site 685727011574 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 685727011575 putative active site [active] 685727011576 putative substrate binding site [chemical binding]; other site 685727011577 ATP binding site [chemical binding]; other site 685727011578 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 685727011579 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 685727011580 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 685727011581 active site 685727011582 Peptidase family M48; Region: Peptidase_M48; pfam01435 685727011583 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727011584 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727011585 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 685727011586 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 685727011587 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 685727011588 active site clefts [active] 685727011589 zinc binding site [ion binding]; other site 685727011590 dimer interface [polypeptide binding]; other site 685727011591 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 685727011592 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685727011593 Walker A/P-loop; other site 685727011594 ATP binding site [chemical binding]; other site 685727011595 Q-loop/lid; other site 685727011596 ABC transporter signature motif; other site 685727011597 Walker B; other site 685727011598 D-loop; other site 685727011599 H-loop/switch region; other site 685727011600 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 685727011601 cobalt transport protein CbiM; Validated; Region: PRK06265 685727011602 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 685727011603 PDGLE domain; Region: PDGLE; pfam13190 685727011604 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 685727011605 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 685727011606 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 685727011607 Walker A/P-loop; other site 685727011608 ATP binding site [chemical binding]; other site 685727011609 Q-loop/lid; other site 685727011610 ABC transporter signature motif; other site 685727011611 Walker B; other site 685727011612 D-loop; other site 685727011613 H-loop/switch region; other site 685727011614 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 685727011615 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 685727011616 DNA binding residues [nucleotide binding] 685727011617 cinnamyl-alcohol dehydrogenase family protein; Region: PLN02986 685727011618 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 685727011619 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 685727011620 HupF/HypC family; Region: HupF_HypC; pfam01455 685727011621 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 685727011622 dimerization interface [polypeptide binding]; other site 685727011623 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 685727011624 ATP binding site [chemical binding]; other site 685727011625 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 685727011626 dimer interface [polypeptide binding]; other site 685727011627 active site 685727011628 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 685727011629 HupF/HypC family; Region: HupF_HypC; cl00394 685727011630 Acylphosphatase; Region: Acylphosphatase; pfam00708 685727011631 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 685727011632 HypF finger; Region: zf-HYPF; pfam07503 685727011633 HypF finger; Region: zf-HYPF; pfam07503 685727011634 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 685727011635 HupF/HypC family; Region: HupF_HypC; pfam01455 685727011636 Putative [NiFe] hydrogenase-specific C-terminal protease. Sequence comparison shows similarity to hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). Maturation of [FeNi] hydrogenases includes formation of...; Region: H2MP_like-1; cd06068 685727011637 nickel binding site [ion binding]; other site 685727011638 IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341 685727011639 NifU-like domain; Region: NifU; cl00484 685727011640 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 685727011641 iron-sulfur cluster [ion binding]; other site 685727011642 [2Fe-2S] cluster binding site [ion binding]; other site 685727011643 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 685727011644 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 685727011645 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 685727011646 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 685727011647 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 685727011648 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 685727011649 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727011650 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 685727011651 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 685727011652 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 685727011653 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 685727011654 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 685727011655 putative DNA binding site [nucleotide binding]; other site 685727011656 putative Zn2+ binding site [ion binding]; other site 685727011657 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 685727011658 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 685727011659 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 685727011660 DNA-binding site [nucleotide binding]; DNA binding site 685727011661 UTRA domain; Region: UTRA; pfam07702 685727011662 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 685727011663 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 685727011664 urocanate hydratase; Provisional; Region: PRK05414 685727011665 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 685727011666 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 685727011667 active site 685727011668 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 685727011669 CoA-transferase family III; Region: CoA_transf_3; pfam02515 685727011670 Transcriptional regulator [Transcription]; Region: IclR; COG1414 685727011671 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 685727011672 Bacterial transcriptional regulator; Region: IclR; pfam01614 685727011673 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 685727011674 Transcriptional regulator [Transcription]; Region: IclR; COG1414 685727011675 Bacterial transcriptional regulator; Region: IclR; pfam01614 685727011676 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 685727011677 active sites [active] 685727011678 tetramer interface [polypeptide binding]; other site 685727011679 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 685727011680 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 685727011681 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685727011682 homodimer interface [polypeptide binding]; other site 685727011683 catalytic residue [active] 685727011684 FAD binding domain; Region: FAD_binding_4; pfam01565 685727011685 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 685727011686 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 685727011687 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 685727011688 Na binding site [ion binding]; other site 685727011689 imidazolonepropionase; Provisional; Region: PRK14085 685727011690 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 685727011691 active site 685727011692 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 685727011693 putative active site [active] 685727011694 putative metal binding site [ion binding]; other site 685727011695 Domain of unknown function (DUF222); Region: DUF222; pfam02720 685727011696 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 685727011697 active site 685727011698 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 685727011699 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 685727011700 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 685727011701 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 685727011702 active site 685727011703 catalytic residues [active] 685727011704 metal binding site [ion binding]; metal-binding site 685727011705 DmpG-like communication domain; Region: DmpG_comm; pfam07836 685727011706 acetaldehyde dehydrogenase; Validated; Region: PRK08300 685727011707 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 685727011708 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 685727011709 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 685727011710 Transcriptional regulator [Transcription]; Region: IclR; COG1414 685727011711 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 685727011712 Bacterial transcriptional regulator; Region: IclR; pfam01614 685727011713 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 685727011714 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 685727011715 AsnC family; Region: AsnC_trans_reg; pfam01037 685727011716 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 685727011717 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 685727011718 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 685727011719 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 685727011720 metal binding site [ion binding]; metal-binding site 685727011721 dimer interface [polypeptide binding]; other site 685727011722 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 685727011723 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 685727011724 active site 685727011725 Transcriptional regulators [Transcription]; Region: MarR; COG1846 685727011726 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 685727011727 dimerization interface [polypeptide binding]; other site 685727011728 putative DNA binding site [nucleotide binding]; other site 685727011729 putative Zn2+ binding site [ion binding]; other site 685727011730 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 685727011731 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 685727011732 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 685727011733 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 685727011734 YCII-related domain; Region: YCII; cl00999 685727011735 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 685727011736 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 685727011737 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 685727011738 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 685727011739 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 685727011740 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 685727011741 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 685727011742 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 685727011743 phosphopeptide binding site; other site 685727011744 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 685727011745 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 685727011746 DNA binding residues [nucleotide binding] 685727011747 dimerization interface [polypeptide binding]; other site 685727011748 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 685727011749 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 685727011750 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 685727011751 DNA binding residues [nucleotide binding] 685727011752 RNA polymerase factor sigma-70; Validated; Region: PRK08241 685727011753 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 685727011754 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 685727011755 DNA binding residues [nucleotide binding] 685727011756 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 685727011757 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 685727011758 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 685727011759 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 685727011760 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 685727011761 PGAP1-like protein; Region: PGAP1; pfam07819 685727011762 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 685727011763 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 685727011764 acyl-activating enzyme (AAE) consensus motif; other site 685727011765 AMP binding site [chemical binding]; other site 685727011766 active site 685727011767 CoA binding site [chemical binding]; other site 685727011768 Transcriptional regulators [Transcription]; Region: FadR; COG2186 685727011769 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 685727011770 DNA-binding site [nucleotide binding]; DNA binding site 685727011771 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 685727011772 Amidohydrolase; Region: Amidohydro_2; pfam04909 685727011773 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 685727011774 intersubunit interface [polypeptide binding]; other site 685727011775 active site 685727011776 Zn2+ binding site [ion binding]; other site 685727011777 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 685727011778 Zn2+ binding site [ion binding]; other site 685727011779 Mg2+ binding site [ion binding]; other site 685727011780 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727011781 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727011782 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 685727011783 Zn2+ binding site [ion binding]; other site 685727011784 Mg2+ binding site [ion binding]; other site 685727011785 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727011786 metabolite-proton symporter; Region: 2A0106; TIGR00883 685727011787 putative substrate translocation pore; other site 685727011788 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 685727011789 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 685727011790 DNA binding residues [nucleotide binding] 685727011791 Pirin-related protein [General function prediction only]; Region: COG1741 685727011792 Pirin; Region: Pirin; pfam02678 685727011793 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 685727011794 Pirin; Region: Pirin; pfam02678 685727011795 Pirin-related protein [General function prediction only]; Region: COG1741 685727011796 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 685727011797 active site 1 [active] 685727011798 active site 2 [active] 685727011799 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 685727011800 CoenzymeA binding site [chemical binding]; other site 685727011801 subunit interaction site [polypeptide binding]; other site 685727011802 PHB binding site; other site 685727011803 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 685727011804 putative active site [active] 685727011805 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 685727011806 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 685727011807 active site 685727011808 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 685727011809 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 685727011810 active site 685727011811 Zn binding site [ion binding]; other site 685727011812 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 685727011813 hypothetical protein; Provisional; Region: PRK02237 685727011814 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 685727011815 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 685727011816 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 685727011817 Ferredoxin [Energy production and conversion]; Region: COG1146 685727011818 4Fe-4S binding domain; Region: Fer4; pfam00037 685727011819 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 685727011820 ferredoxin-NADP+ reductase; Region: PLN02852 685727011821 Dodecin; Region: Dodecin; pfam07311 685727011822 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 685727011823 Beta-lactamase; Region: Beta-lactamase; pfam00144 685727011824 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 685727011825 nucleotide binding site [chemical binding]; other site 685727011826 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 685727011827 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 685727011828 active site 685727011829 DNA binding site [nucleotide binding] 685727011830 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 685727011831 DNA binding site [nucleotide binding] 685727011832 OsmC-like protein; Region: OsmC; pfam02566 685727011833 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 685727011834 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 685727011835 oligomer interface [polypeptide binding]; other site 685727011836 metal binding site [ion binding]; metal-binding site 685727011837 metal binding site [ion binding]; metal-binding site 685727011838 putative Cl binding site [ion binding]; other site 685727011839 basic sphincter; other site 685727011840 hydrophobic gate; other site 685727011841 periplasmic entrance; other site 685727011842 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 685727011843 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 685727011844 trimer interface [polypeptide binding]; other site 685727011845 putative metal binding site [ion binding]; other site 685727011846 Transcriptional regulators [Transcription]; Region: FadR; COG2186 685727011847 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 685727011848 DNA-binding site [nucleotide binding]; DNA binding site 685727011849 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 685727011850 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 685727011851 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 685727011852 DNA binding residues [nucleotide binding] 685727011853 dimerization interface [polypeptide binding]; other site 685727011854 acyl-CoA synthetase; Validated; Region: PRK08162 685727011855 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 685727011856 acyl-activating enzyme (AAE) consensus motif; other site 685727011857 putative active site [active] 685727011858 AMP binding site [chemical binding]; other site 685727011859 putative CoA binding site [chemical binding]; other site 685727011860 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 685727011861 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 685727011862 catalytic Zn binding site [ion binding]; other site 685727011863 NAD(P) binding site [chemical binding]; other site 685727011864 structural Zn binding site [ion binding]; other site 685727011865 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 685727011866 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 685727011867 active site 685727011868 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 685727011869 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 685727011870 active site 685727011871 short chain dehydrogenase; Provisional; Region: PRK07791 685727011872 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727011873 NAD(P) binding site [chemical binding]; other site 685727011874 active site 685727011875 enoyl-CoA hydratase; Region: PLN02864 685727011876 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 685727011877 active site 685727011878 catalytic site [active] 685727011879 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 685727011880 active site 2 [active] 685727011881 active site 1 [active] 685727011882 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 685727011883 hydrophobic ligand binding site; other site 685727011884 lipid-transfer protein; Provisional; Region: PRK08256 685727011885 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 685727011886 active site 685727011887 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727011888 Condensation domain; Region: Condensation; pfam00668 685727011889 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 685727011890 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 685727011891 Condensation domain; Region: Condensation; pfam00668 685727011892 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 685727011893 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 685727011894 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 685727011895 acyl-activating enzyme (AAE) consensus motif; other site 685727011896 AMP binding site [chemical binding]; other site 685727011897 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 685727011898 peptide synthase; Provisional; Region: PRK12316 685727011899 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 685727011900 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 685727011901 acyl-activating enzyme (AAE) consensus motif; other site 685727011902 AMP binding site [chemical binding]; other site 685727011903 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 685727011904 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 685727011905 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 685727011906 acyl-activating enzyme (AAE) consensus motif; other site 685727011907 AMP binding site [chemical binding]; other site 685727011908 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 685727011909 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 685727011910 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 685727011911 acyl-activating enzyme (AAE) consensus motif; other site 685727011912 AMP binding site [chemical binding]; other site 685727011913 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 685727011914 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 685727011915 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 685727011916 acyl-activating enzyme (AAE) consensus motif; other site 685727011917 AMP binding site [chemical binding]; other site 685727011918 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 685727011919 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 685727011920 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 685727011921 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 685727011922 acyl-activating enzyme (AAE) consensus motif; other site 685727011923 AMP binding site [chemical binding]; other site 685727011924 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 685727011925 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 685727011926 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727011927 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 685727011928 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 685727011929 FAD binding site [chemical binding]; other site 685727011930 homotetramer interface [polypeptide binding]; other site 685727011931 substrate binding pocket [chemical binding]; other site 685727011932 catalytic base [active] 685727011933 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 685727011934 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 685727011935 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 685727011936 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 685727011937 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 685727011938 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 685727011939 hydrophobic ligand binding site; other site 685727011940 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 685727011941 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 685727011942 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727011943 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727011944 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 685727011945 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 685727011946 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 685727011947 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 685727011948 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727011949 Major Facilitator Superfamily; Region: MFS_1; pfam07690 685727011950 putative substrate translocation pore; other site 685727011951 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 685727011952 Amidase; Region: Amidase; cl11426 685727011953 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 685727011954 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 685727011955 Walker A/P-loop; other site 685727011956 ATP binding site [chemical binding]; other site 685727011957 Q-loop/lid; other site 685727011958 ABC transporter signature motif; other site 685727011959 Walker B; other site 685727011960 D-loop; other site 685727011961 H-loop/switch region; other site 685727011962 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 685727011963 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 685727011964 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 685727011965 Walker A/P-loop; other site 685727011966 ATP binding site [chemical binding]; other site 685727011967 Q-loop/lid; other site 685727011968 ABC transporter signature motif; other site 685727011969 Walker B; other site 685727011970 D-loop; other site 685727011971 H-loop/switch region; other site 685727011972 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 685727011973 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 685727011974 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685727011975 putative PBP binding loops; other site 685727011976 ABC-ATPase subunit interface; other site 685727011977 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 685727011978 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685727011979 dimer interface [polypeptide binding]; other site 685727011980 conserved gate region; other site 685727011981 putative PBP binding loops; other site 685727011982 ABC-ATPase subunit interface; other site 685727011983 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 685727011984 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 685727011985 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 685727011986 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 685727011987 active site 685727011988 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 685727011989 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 685727011990 DNA-binding site [nucleotide binding]; DNA binding site 685727011991 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 685727011992 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 685727011993 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 685727011994 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 685727011995 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 685727011996 active site 685727011997 putative substrate binding pocket [chemical binding]; other site 685727011998 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 685727011999 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 685727012000 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 685727012001 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727012002 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727012003 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 685727012004 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 685727012005 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 685727012006 nucleoside/Zn binding site; other site 685727012007 dimer interface [polypeptide binding]; other site 685727012008 catalytic motif [active] 685727012009 cyanate hydratase; Validated; Region: PRK02866 685727012010 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 685727012011 oligomer interface [polypeptide binding]; other site 685727012012 active site 685727012013 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 685727012014 active site clefts [active] 685727012015 zinc binding site [ion binding]; other site 685727012016 dimer interface [polypeptide binding]; other site 685727012017 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 685727012018 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685727012019 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 685727012020 dimerization interface [polypeptide binding]; other site 685727012021 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 685727012022 metabolite-proton symporter; Region: 2A0106; TIGR00883 685727012023 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727012024 putative substrate translocation pore; other site 685727012025 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 685727012026 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 685727012027 acyl-activating enzyme (AAE) consensus motif; other site 685727012028 AMP binding site [chemical binding]; other site 685727012029 active site 685727012030 CoA binding site [chemical binding]; other site 685727012031 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 685727012032 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 685727012033 cyclase homology domain; Region: CHD; cd07302 685727012034 nucleotidyl binding site; other site 685727012035 metal binding site [ion binding]; metal-binding site 685727012036 dimer interface [polypeptide binding]; other site 685727012037 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727012038 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 685727012039 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 685727012040 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 685727012041 Walker A/P-loop; other site 685727012042 ATP binding site [chemical binding]; other site 685727012043 Q-loop/lid; other site 685727012044 ABC transporter signature motif; other site 685727012045 Walker B; other site 685727012046 D-loop; other site 685727012047 H-loop/switch region; other site 685727012048 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 685727012049 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 685727012050 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 685727012051 Walker A/P-loop; other site 685727012052 ATP binding site [chemical binding]; other site 685727012053 Q-loop/lid; other site 685727012054 ABC transporter signature motif; other site 685727012055 Walker B; other site 685727012056 D-loop; other site 685727012057 H-loop/switch region; other site 685727012058 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 685727012059 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 685727012060 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685727012061 dimer interface [polypeptide binding]; other site 685727012062 conserved gate region; other site 685727012063 putative PBP binding loops; other site 685727012064 ABC-ATPase subunit interface; other site 685727012065 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 685727012066 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685727012067 ABC-ATPase subunit interface; other site 685727012068 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 685727012069 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 685727012070 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 685727012071 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 685727012072 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 685727012073 acyl-activating enzyme (AAE) consensus motif; other site 685727012074 acyl-activating enzyme (AAE) consensus motif; other site 685727012075 putative AMP binding site [chemical binding]; other site 685727012076 putative active site [active] 685727012077 putative CoA binding site [chemical binding]; other site 685727012078 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 685727012079 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727012080 NAD(P) binding site [chemical binding]; other site 685727012081 active site 685727012082 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 685727012083 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 685727012084 dimer interface [polypeptide binding]; other site 685727012085 active site 685727012086 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 685727012087 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 685727012088 phosphate binding site [ion binding]; other site 685727012089 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_7; cd12166 685727012090 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 685727012091 putative ligand binding site [chemical binding]; other site 685727012092 putative NAD binding site [chemical binding]; other site 685727012093 catalytic site [active] 685727012094 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases [Carbohydrate transport and metabolism]; Region: AraD; COG0235 685727012095 intersubunit interface [polypeptide binding]; other site 685727012096 active site 685727012097 Zn2+ binding site [ion binding]; other site 685727012098 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 685727012099 Amidohydrolase; Region: Amidohydro_2; pfam04909 685727012100 Transcriptional regulator [Transcription]; Region: IclR; COG1414 685727012101 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 685727012102 Bacterial transcriptional regulator; Region: IclR; pfam01614 685727012103 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 685727012104 enoyl-CoA hydratase; Provisional; Region: PRK06688 685727012105 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 685727012106 substrate binding site [chemical binding]; other site 685727012107 oxyanion hole (OAH) forming residues; other site 685727012108 trimer interface [polypeptide binding]; other site 685727012109 NMT1-like family; Region: NMT1_2; pfam13379 685727012110 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 685727012111 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 685727012112 CoA-transferase family III; Region: CoA_transf_3; pfam02515 685727012113 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 685727012114 CoA-transferase family III; Region: CoA_transf_3; pfam02515 685727012115 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 685727012116 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 685727012117 putative NAD(P) binding site [chemical binding]; other site 685727012118 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 685727012119 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 685727012120 acyl-activating enzyme (AAE) consensus motif; other site 685727012121 putative AMP binding site [chemical binding]; other site 685727012122 putative active site [active] 685727012123 putative CoA binding site [chemical binding]; other site 685727012124 Transcriptional regulator [Transcription]; Region: IclR; COG1414 685727012125 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 685727012126 Bacterial transcriptional regulator; Region: IclR; pfam01614 685727012127 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 685727012128 Ferredoxin [Energy production and conversion]; Region: COG1146 685727012129 4Fe-4S binding domain; Region: Fer4; pfam00037 685727012130 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 685727012131 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 685727012132 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 685727012133 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 685727012134 intersubunit interface [polypeptide binding]; other site 685727012135 active site 685727012136 Zn2+ binding site [ion binding]; other site 685727012137 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 685727012138 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685727012139 dimer interface [polypeptide binding]; other site 685727012140 conserved gate region; other site 685727012141 putative PBP binding loops; other site 685727012142 ABC-ATPase subunit interface; other site 685727012143 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 685727012144 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 685727012145 Walker A/P-loop; other site 685727012146 ATP binding site [chemical binding]; other site 685727012147 Q-loop/lid; other site 685727012148 ABC transporter signature motif; other site 685727012149 Walker B; other site 685727012150 D-loop; other site 685727012151 H-loop/switch region; other site 685727012152 NMT1-like family; Region: NMT1_2; pfam13379 685727012153 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 685727012154 substrate binding pocket [chemical binding]; other site 685727012155 membrane-bound complex binding site; other site 685727012156 hinge residues; other site 685727012157 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 685727012158 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_11; cd12175 685727012159 putative ligand binding site [chemical binding]; other site 685727012160 putative NAD binding site [chemical binding]; other site 685727012161 catalytic site [active] 685727012162 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 685727012163 Subunit B of the Class III Extradiol dioxygenase, Protocatechuate 4,5-dioxygenase, and simlar enzymes; Region: PCA_45_Doxase_B_like; cd07359 685727012164 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 685727012165 active site 685727012166 Fe(II) binding site [ion binding]; other site 685727012167 dimer interface [polypeptide binding]; other site 685727012168 tetramer interface [polypeptide binding]; other site 685727012169 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 685727012170 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 685727012171 metal binding site [ion binding]; metal-binding site 685727012172 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 685727012173 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 685727012174 iron-sulfur cluster [ion binding]; other site 685727012175 [2Fe-2S] cluster binding site [ion binding]; other site 685727012176 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 685727012177 hydrophobic ligand binding site; other site 685727012178 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 685727012179 active site 2 [active] 685727012180 active site 1 [active] 685727012181 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 685727012182 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 685727012183 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 685727012184 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727012185 putative substrate translocation pore; other site 685727012186 Transcriptional regulator [Transcription]; Region: IclR; COG1414 685727012187 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 685727012188 Bacterial transcriptional regulator; Region: IclR; pfam01614 685727012189 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 685727012190 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_11; cd12175 685727012191 putative ligand binding site [chemical binding]; other site 685727012192 putative NAD binding site [chemical binding]; other site 685727012193 catalytic site [active] 685727012194 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 685727012195 classical (c) SDRs; Region: SDR_c; cd05233 685727012196 NAD(P) binding site [chemical binding]; other site 685727012197 active site 685727012198 short chain dehydrogenase; Provisional; Region: PRK07856 685727012199 classical (c) SDRs; Region: SDR_c; cd05233 685727012200 NAD(P) binding site [chemical binding]; other site 685727012201 active site 685727012202 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 685727012203 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 685727012204 active site 2 [active] 685727012205 active site 1 [active] 685727012206 lipid-transfer protein; Provisional; Region: PRK07855 685727012207 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 685727012208 active site 685727012209 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 685727012210 putative active site [active] 685727012211 putative catalytic site [active] 685727012212 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 685727012213 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 685727012214 active site 685727012215 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 685727012216 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 685727012217 DUF35 OB-fold domain; Region: DUF35; pfam01796 685727012218 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 685727012219 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 685727012220 active site 685727012221 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727012222 NAD(P) binding site [chemical binding]; other site 685727012223 active site 685727012224 acyl-CoA synthetase; Provisional; Region: PRK13388 685727012225 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 685727012226 acyl-activating enzyme (AAE) consensus motif; other site 685727012227 AMP binding site [chemical binding]; other site 685727012228 active site 685727012229 CoA binding site [chemical binding]; other site 685727012230 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 685727012231 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 685727012232 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 685727012233 acyl-activating enzyme (AAE) consensus motif; other site 685727012234 acyl-activating enzyme (AAE) consensus motif; other site 685727012235 putative AMP binding site [chemical binding]; other site 685727012236 putative active site [active] 685727012237 putative CoA binding site [chemical binding]; other site 685727012238 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 685727012239 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 685727012240 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 685727012241 Helix-turn-helix domain; Region: HTH_18; pfam12833 685727012242 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 685727012243 Mechanosensitive ion channel; Region: MS_channel; pfam00924 685727012244 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 685727012245 classical (c) SDRs; Region: SDR_c; cd05233 685727012246 NAD(P) binding site [chemical binding]; other site 685727012247 active site 685727012248 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 685727012249 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 685727012250 CoenzymeA binding site [chemical binding]; other site 685727012251 subunit interaction site [polypeptide binding]; other site 685727012252 PHB binding site; other site 685727012253 enoyl-CoA hydratase; Region: PLN02864 685727012254 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 685727012255 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 685727012256 dimer interaction site [polypeptide binding]; other site 685727012257 substrate-binding tunnel; other site 685727012258 active site 685727012259 catalytic site [active] 685727012260 substrate binding site [chemical binding]; other site 685727012261 lipid-transfer protein; Provisional; Region: PRK08256 685727012262 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 685727012263 active site 685727012264 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 685727012265 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 685727012266 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 685727012267 active site 685727012268 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 685727012269 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 685727012270 active site 685727012271 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 685727012272 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 685727012273 dimer interface [polypeptide binding]; other site 685727012274 active site 685727012275 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727012276 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727012277 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 685727012278 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 685727012279 Flavin binding site [chemical binding]; other site 685727012280 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 685727012281 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 685727012282 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 685727012283 hydrophobic ligand binding site; other site 685727012284 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727012285 short chain dehydrogenase; Provisional; Region: PRK07454 685727012286 NAD(P) binding site [chemical binding]; other site 685727012287 active site 685727012288 SnoaL-like domain; Region: SnoaL_4; pfam13577 685727012289 SnoaL-like domain; Region: SnoaL_4; pfam13577 685727012290 Protein of unknown function DUF72; Region: DUF72; pfam01904 685727012291 Putative esterase; Region: Esterase; pfam00756 685727012292 S-formylglutathione hydrolase; Region: PLN02442 685727012293 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 685727012294 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 685727012295 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 685727012296 active site 685727012297 Fe binding site [ion binding]; other site 685727012298 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 685727012299 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 685727012300 active site 685727012301 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12835 685727012302 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 685727012303 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 685727012304 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 685727012305 Transcriptional regulator [Transcription]; Region: IclR; COG1414 685727012306 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 685727012307 Bacterial transcriptional regulator; Region: IclR; pfam01614 685727012308 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 685727012309 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 685727012310 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 685727012311 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 685727012312 SnoaL-like domain; Region: SnoaL_3; pfam13474 685727012313 acyl-CoA synthetase; Validated; Region: PRK07798 685727012314 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 685727012315 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 685727012316 acyl-activating enzyme (AAE) consensus motif; other site 685727012317 acyl-activating enzyme (AAE) consensus motif; other site 685727012318 putative AMP binding site [chemical binding]; other site 685727012319 putative active site [active] 685727012320 putative CoA binding site [chemical binding]; other site 685727012321 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 685727012322 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727012323 NAD(P) binding site [chemical binding]; other site 685727012324 active site 685727012325 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 685727012326 classical (c) SDRs; Region: SDR_c; cd05233 685727012327 NAD(P) binding site [chemical binding]; other site 685727012328 active site 685727012329 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 685727012330 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 685727012331 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 685727012332 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 685727012333 active site 685727012334 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 685727012335 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 685727012336 putative active site [active] 685727012337 putative FMN binding site [chemical binding]; other site 685727012338 putative substrate binding site [chemical binding]; other site 685727012339 putative catalytic residue [active] 685727012340 H+ Antiporter protein; Region: 2A0121; TIGR00900 685727012341 Transcriptional regulator [Transcription]; Region: LysR; COG0583 685727012342 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685727012343 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 685727012344 dimerization interface [polypeptide binding]; other site 685727012345 Domain of unknown function (DUF222); Region: DUF222; pfam02720 685727012346 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 685727012347 active site 685727012348 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 685727012349 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 685727012350 RNA/DNA hybrid binding site [nucleotide binding]; other site 685727012351 active site 685727012352 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 685727012353 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 685727012354 minor groove reading motif; other site 685727012355 helix-hairpin-helix signature motif; other site 685727012356 active site 685727012357 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 685727012358 classical (c) SDRs; Region: SDR_c; cd05233 685727012359 NAD(P) binding site [chemical binding]; other site 685727012360 active site 685727012361 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 685727012362 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 685727012363 NAD(P) binding site [chemical binding]; other site 685727012364 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 685727012365 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 685727012366 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 685727012367 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 685727012368 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 685727012369 DNA binding residues [nucleotide binding] 685727012370 dimerization interface [polypeptide binding]; other site 685727012371 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 685727012372 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727012373 NAD(P) binding site [chemical binding]; other site 685727012374 active site 685727012375 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 685727012376 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 685727012377 NAD(P) binding site [chemical binding]; other site 685727012378 catalytic residues [active] 685727012379 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 685727012380 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727012381 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727012382 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 685727012383 SnoaL-like domain; Region: SnoaL_4; pfam13577 685727012384 SnoaL-like domain; Region: SnoaL_4; pfam13577 685727012385 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 685727012386 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 685727012387 putative active site [active] 685727012388 putative FMN binding site [chemical binding]; other site 685727012389 putative substrate binding site [chemical binding]; other site 685727012390 putative catalytic residue [active] 685727012391 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 685727012392 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 685727012393 NAD binding site [chemical binding]; other site 685727012394 substrate binding site [chemical binding]; other site 685727012395 catalytic Zn binding site [ion binding]; other site 685727012396 structural Zn binding site [ion binding]; other site 685727012397 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 685727012398 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727012399 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727012400 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 685727012401 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 685727012402 enoyl-CoA hydratase; Provisional; Region: PRK08252 685727012403 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 685727012404 substrate binding site [chemical binding]; other site 685727012405 oxyanion hole (OAH) forming residues; other site 685727012406 trimer interface [polypeptide binding]; other site 685727012407 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727012408 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727012409 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727012410 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727012411 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 685727012412 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 685727012413 fumarylacetoacetase; Region: PLN02856 685727012414 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 685727012415 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 685727012416 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 685727012417 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 685727012418 MarR family; Region: MarR; pfam01047 685727012419 Transcriptional regulator [Transcription]; Region: IclR; COG1414 685727012420 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 685727012421 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 685727012422 Cytochrome P450; Region: p450; cl12078 685727012423 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 685727012424 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 685727012425 FMN-binding pocket [chemical binding]; other site 685727012426 flavin binding motif; other site 685727012427 phosphate binding motif [ion binding]; other site 685727012428 beta-alpha-beta structure motif; other site 685727012429 NAD binding pocket [chemical binding]; other site 685727012430 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 685727012431 catalytic loop [active] 685727012432 iron binding site [ion binding]; other site 685727012433 metabolite-proton symporter; Region: 2A0106; TIGR00883 685727012434 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727012435 putative substrate translocation pore; other site 685727012436 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 685727012437 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 685727012438 SnoaL-like domain; Region: SnoaL_4; pfam13577 685727012439 SnoaL-like domain; Region: SnoaL_3; pfam13474 685727012440 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727012441 metabolite-proton symporter; Region: 2A0106; TIGR00883 685727012442 putative substrate translocation pore; other site 685727012443 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 685727012444 Predicted oxidoreductase [General function prediction only]; Region: COG3573 685727012445 classical (c) SDRs; Region: SDR_c; cd05233 685727012446 NAD(P) binding site [chemical binding]; other site 685727012447 active site 685727012448 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 685727012449 classical (c) SDRs; Region: SDR_c; cd05233 685727012450 NAD(P) binding site [chemical binding]; other site 685727012451 active site 685727012452 SnoaL-like domain; Region: SnoaL_4; pfam13577 685727012453 Transcriptional regulator [Transcription]; Region: IclR; COG1414 685727012454 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 685727012455 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727012456 Major Facilitator Superfamily; Region: MFS_1; pfam07690 685727012457 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 685727012458 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 685727012459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727012460 Major Facilitator Superfamily; Region: MFS_1; pfam07690 685727012461 putative substrate translocation pore; other site 685727012462 Transcriptional regulator [Transcription]; Region: LysR; COG0583 685727012463 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685727012464 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 685727012465 dimerization interface [polypeptide binding]; other site 685727012466 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 685727012467 cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207 685727012468 active site 685727012469 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 685727012470 TAP-like protein; Region: Abhydrolase_4; pfam08386 685727012471 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 685727012472 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 685727012473 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 685727012474 active site 685727012475 DNA binding site [nucleotide binding] 685727012476 catalytic site [active] 685727012477 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 685727012478 Domain of unknown function DUF21; Region: DUF21; pfam01595 685727012479 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 685727012480 Transporter associated domain; Region: CorC_HlyC; smart01091 685727012481 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 685727012482 classical (c) SDRs; Region: SDR_c; cd05233 685727012483 NAD(P) binding site [chemical binding]; other site 685727012484 active site 685727012485 MMPL family; Region: MMPL; pfam03176 685727012486 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 685727012487 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 685727012488 tetramer interface [polypeptide binding]; other site 685727012489 heme binding pocket [chemical binding]; other site 685727012490 NADPH binding site [chemical binding]; other site 685727012491 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 685727012492 Trp docking motif [polypeptide binding]; other site 685727012493 PQQ-like domain; Region: PQQ_2; pfam13360 685727012494 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 685727012495 AlkA N-terminal domain; Region: AlkA_N; smart01009 685727012496 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 685727012497 minor groove reading motif; other site 685727012498 helix-hairpin-helix signature motif; other site 685727012499 substrate binding pocket [chemical binding]; other site 685727012500 active site 685727012501 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 685727012502 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 685727012503 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 685727012504 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 685727012505 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 685727012506 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 685727012507 DNA binding site [nucleotide binding] 685727012508 active site 685727012509 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 685727012510 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 685727012511 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 685727012512 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 685727012513 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 685727012514 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 685727012515 DNA binding site [nucleotide binding] 685727012516 active site 685727012517 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 685727012518 putative hydrophobic ligand binding site [chemical binding]; other site 685727012519 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 685727012520 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 685727012521 putative DNA binding site [nucleotide binding]; other site 685727012522 putative Zn2+ binding site [ion binding]; other site 685727012523 AsnC family; Region: AsnC_trans_reg; pfam01037 685727012524 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 685727012525 Ligand Binding Site [chemical binding]; other site 685727012526 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 685727012527 Ligand Binding Site [chemical binding]; other site 685727012528 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 685727012529 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 685727012530 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 685727012531 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 685727012532 dimer interface [polypeptide binding]; other site 685727012533 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 685727012534 active site 685727012535 Fe binding site [ion binding]; other site 685727012536 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 685727012537 classical (c) SDRs; Region: SDR_c; cd05233 685727012538 NAD(P) binding site [chemical binding]; other site 685727012539 active site 685727012540 Domain of unknown function (DUF309); Region: DUF309; pfam03745 685727012541 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 685727012542 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 685727012543 hydrophobic ligand binding site; other site 685727012544 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 685727012545 Uncharacterized conserved protein [Function unknown]; Region: COG3379 685727012546 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 685727012547 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 685727012548 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 685727012549 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 685727012550 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727012551 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727012552 NADH(P)-binding; Region: NAD_binding_10; pfam13460 685727012553 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727012554 NAD(P) binding site [chemical binding]; other site 685727012555 active site 685727012556 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439 685727012557 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 685727012558 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 685727012559 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 685727012560 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 685727012561 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 685727012562 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 685727012563 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 685727012564 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 685727012565 putative NAD(P) binding site [chemical binding]; other site 685727012566 putative active site [active] 685727012567 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 685727012568 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 685727012569 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 685727012570 catalytic site [active] 685727012571 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 685727012572 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727012573 NAD(P) binding site [chemical binding]; other site 685727012574 active site 685727012575 Clp amino terminal domain; Region: Clp_N; pfam02861 685727012576 Clp amino terminal domain; Region: Clp_N; pfam02861 685727012577 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 685727012578 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 685727012579 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 685727012580 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 685727012581 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 685727012582 L-ascorbate oxidase, fungal type; Region: ascorbOXfungal; TIGR03390 685727012583 Multicopper oxidase; Region: Cu-oxidase; pfam00394 685727012584 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 685727012585 Methylamine dehydrogenase, L chain; Region: Me-amine-dh_L; cl03812 685727012586 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 685727012587 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 685727012588 Methylamine utilisation protein MauE; Region: MauE; pfam07291 685727012589 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 685727012590 Transcriptional regulator [Transcription]; Region: IclR; COG1414 685727012591 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 685727012592 Bacterial transcriptional regulator; Region: IclR; pfam01614 685727012593 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 685727012594 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 685727012595 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685727012596 ABC-ATPase subunit interface; other site 685727012597 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 685727012598 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 685727012599 Walker A/P-loop; other site 685727012600 ATP binding site [chemical binding]; other site 685727012601 Q-loop/lid; other site 685727012602 ABC transporter signature motif; other site 685727012603 Walker B; other site 685727012604 D-loop; other site 685727012605 H-loop/switch region; other site 685727012606 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685727012607 ABC-ATPase subunit interface; other site 685727012608 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 685727012609 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 685727012610 putative molybdopterin cofactor binding site [chemical binding]; other site 685727012611 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 685727012612 putative molybdopterin cofactor binding site; other site 685727012613 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727012614 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727012615 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 685727012616 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 685727012617 substrate binding site [chemical binding]; other site 685727012618 oxyanion hole (OAH) forming residues; other site 685727012619 trimer interface [polypeptide binding]; other site 685727012620 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 685727012621 classical (c) SDRs; Region: SDR_c; cd05233 685727012622 NAD(P) binding site [chemical binding]; other site 685727012623 active site 685727012624 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 685727012625 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727012626 NAD(P) binding site [chemical binding]; other site 685727012627 active site 685727012628 Major Facilitator Superfamily; Region: MFS_1; pfam07690 685727012629 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727012630 putative substrate translocation pore; other site 685727012631 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 685727012632 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 685727012633 potential catalytic triad [active] 685727012634 conserved cys residue [active] 685727012635 Transcriptional regulator [Transcription]; Region: LytR; COG1316 685727012636 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 685727012637 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 685727012638 putative NAD(P) binding site [chemical binding]; other site 685727012639 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 685727012640 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 685727012641 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 685727012642 hydrophobic ligand binding site; other site 685727012643 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 685727012644 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 685727012645 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 685727012646 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 685727012647 active site 685727012648 phosphorylation site [posttranslational modification] 685727012649 intermolecular recognition site; other site 685727012650 dimerization interface [polypeptide binding]; other site 685727012651 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 685727012652 DNA binding site [nucleotide binding] 685727012653 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 685727012654 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 685727012655 dimer interface [polypeptide binding]; other site 685727012656 phosphorylation site [posttranslational modification] 685727012657 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 685727012658 ATP binding site [chemical binding]; other site 685727012659 Mg2+ binding site [ion binding]; other site 685727012660 G-X-G motif; other site 685727012661 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 685727012662 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 685727012663 active site 685727012664 dimer interface [polypeptide binding]; other site 685727012665 metal binding site [ion binding]; metal-binding site 685727012666 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727012667 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727012668 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 685727012669 acyl-CoA synthetase; Validated; Region: PRK08316 685727012670 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 685727012671 acyl-activating enzyme (AAE) consensus motif; other site 685727012672 AMP binding site [chemical binding]; other site 685727012673 active site 685727012674 CoA binding site [chemical binding]; other site 685727012675 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 685727012676 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 685727012677 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 685727012678 CoA-transferase family III; Region: CoA_transf_3; pfam02515 685727012679 4-coumarate--CoA ligase; Region: PLN02246 685727012680 4-Coumarate-CoA Ligase (4CL); Region: 4CL; cd05904 685727012681 acyl-activating enzyme (AAE) consensus motif; other site 685727012682 active site 685727012683 putative CoA binding site [chemical binding]; other site 685727012684 AMP binding site [chemical binding]; other site 685727012685 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 685727012686 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 685727012687 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 685727012688 DNA binding residues [nucleotide binding] 685727012689 dimerization interface [polypeptide binding]; other site 685727012690 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 685727012691 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727012692 putative substrate translocation pore; other site 685727012693 UreD urease accessory protein; Region: UreD; cl00530 685727012694 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 685727012695 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 685727012696 UreF; Region: UreF; pfam01730 685727012697 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 685727012698 gamma-beta subunit interface [polypeptide binding]; other site 685727012699 alpha-beta subunit interface [polypeptide binding]; other site 685727012700 urease subunit alpha; Reviewed; Region: ureC; PRK13207 685727012701 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 685727012702 subunit interactions [polypeptide binding]; other site 685727012703 active site 685727012704 flap region; other site 685727012705 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 685727012706 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 685727012707 alpha-gamma subunit interface [polypeptide binding]; other site 685727012708 beta-gamma subunit interface [polypeptide binding]; other site 685727012709 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 685727012710 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 685727012711 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 685727012712 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 685727012713 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685727012714 dimer interface [polypeptide binding]; other site 685727012715 conserved gate region; other site 685727012716 putative PBP binding loops; other site 685727012717 ABC-ATPase subunit interface; other site 685727012718 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 685727012719 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685727012720 dimer interface [polypeptide binding]; other site 685727012721 conserved gate region; other site 685727012722 putative PBP binding loops; other site 685727012723 ABC-ATPase subunit interface; other site 685727012724 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 685727012725 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 685727012726 Walker A/P-loop; other site 685727012727 ATP binding site [chemical binding]; other site 685727012728 Q-loop/lid; other site 685727012729 ABC transporter signature motif; other site 685727012730 Walker B; other site 685727012731 D-loop; other site 685727012732 H-loop/switch region; other site 685727012733 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 685727012734 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 685727012735 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 685727012736 Walker A/P-loop; other site 685727012737 ATP binding site [chemical binding]; other site 685727012738 Q-loop/lid; other site 685727012739 ABC transporter signature motif; other site 685727012740 Walker B; other site 685727012741 D-loop; other site 685727012742 H-loop/switch region; other site 685727012743 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 685727012744 RibD C-terminal domain; Region: RibD_C; cl17279 685727012745 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 685727012746 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 685727012747 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 685727012748 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 685727012749 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 685727012750 AzlC protein; Region: AzlC; cl00570 685727012751 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 685727012752 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 685727012753 putative DNA binding site [nucleotide binding]; other site 685727012754 putative Zn2+ binding site [ion binding]; other site 685727012755 AsnC family; Region: AsnC_trans_reg; pfam01037 685727012756 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 685727012757 ATP-binding site [chemical binding]; other site 685727012758 Gluconate-6-phosphate binding site [chemical binding]; other site 685727012759 Shikimate kinase; Region: SKI; pfam01202 685727012760 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 685727012761 Peptidase family M23; Region: Peptidase_M23; pfam01551 685727012762 acyl-CoA synthetase; Validated; Region: PRK08316 685727012763 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 685727012764 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 685727012765 acyl-activating enzyme (AAE) consensus motif; other site 685727012766 acyl-activating enzyme (AAE) consensus motif; other site 685727012767 putative AMP binding site [chemical binding]; other site 685727012768 putative active site [active] 685727012769 putative CoA binding site [chemical binding]; other site 685727012770 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 685727012771 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 685727012772 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 685727012773 Cytochrome P450; Region: p450; cl12078 685727012774 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727012775 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727012776 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 685727012777 putative active site [active] 685727012778 putative substrate binding site [chemical binding]; other site 685727012779 ATP binding site [chemical binding]; other site 685727012780 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 685727012781 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 685727012782 dimer interface [polypeptide binding]; other site 685727012783 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 685727012784 Ligand binding site; other site 685727012785 Putative Catalytic site; other site 685727012786 DXD motif; other site 685727012787 hypothetical protein; Provisional; Region: PRK01346 685727012788 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 685727012789 Coenzyme A binding pocket [chemical binding]; other site 685727012790 Transcriptional regulator [Transcription]; Region: LysR; COG0583 685727012791 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685727012792 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 685727012793 dimerization interface [polypeptide binding]; other site 685727012794 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 685727012795 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727012796 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727012797 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 685727012798 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 685727012799 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 685727012800 dimer interface [polypeptide binding]; other site 685727012801 acyl-activating enzyme (AAE) consensus motif; other site 685727012802 putative active site [active] 685727012803 AMP binding site [chemical binding]; other site 685727012804 putative CoA binding site [chemical binding]; other site 685727012805 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 685727012806 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 685727012807 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 685727012808 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 685727012809 homotrimer interaction site [polypeptide binding]; other site 685727012810 putative active site [active] 685727012811 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 685727012812 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 685727012813 Domain of unknown function (DUF222); Region: DUF222; pfam02720 685727012814 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 685727012815 active site 685727012816 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 685727012817 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 685727012818 putative active site [active] 685727012819 putative FMN binding site [chemical binding]; other site 685727012820 putative substrate binding site [chemical binding]; other site 685727012821 putative catalytic residue [active] 685727012822 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 685727012823 benzoate transport; Region: 2A0115; TIGR00895 685727012824 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727012825 putative substrate translocation pore; other site 685727012826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727012827 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 685727012828 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 685727012829 tetramerization interface [polypeptide binding]; other site 685727012830 NAD(P) binding site [chemical binding]; other site 685727012831 catalytic residues [active] 685727012832 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 685727012833 PhoD-like phosphatase; Region: PhoD; pfam09423 685727012834 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 685727012835 putative active site [active] 685727012836 putative metal binding site [ion binding]; other site 685727012837 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 685727012838 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 685727012839 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 685727012840 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 685727012841 DNA binding residues [nucleotide binding] 685727012842 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 685727012843 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 685727012844 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 685727012845 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 685727012846 Zn binding site [ion binding]; other site 685727012847 enoyl-CoA hydratase; Validated; Region: PRK08139 685727012848 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 685727012849 substrate binding site [chemical binding]; other site 685727012850 oxyanion hole (OAH) forming residues; other site 685727012851 trimer interface [polypeptide binding]; other site 685727012852 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 685727012853 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 685727012854 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 685727012855 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; pfam04655 685727012856 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 685727012857 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 685727012858 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 685727012859 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 685727012860 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 685727012861 Hemerythrin-like domain; Region: Hr-like; cd12108 685727012862 classical (c) SDRs; Region: SDR_c; cd05233 685727012863 short chain dehydrogenase; Provisional; Region: PRK07832 685727012864 NAD(P) binding site [chemical binding]; other site 685727012865 active site 685727012866 Cutinase; Region: Cutinase; pfam01083 685727012867 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 685727012868 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 685727012869 DNA binding residues [nucleotide binding] 685727012870 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 685727012871 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 685727012872 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 685727012873 potential catalytic triad [active] 685727012874 conserved cys residue [active] 685727012875 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 685727012876 A new structural DNA glycosylase; Region: AlkD_like; cd06561 685727012877 active site 685727012878 Transcriptional regulator [Transcription]; Region: LysR; COG0583 685727012879 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685727012880 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 685727012881 dimerization interface [polypeptide binding]; other site 685727012882 Major Facilitator Superfamily; Region: MFS_1; pfam07690 685727012883 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727012884 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 685727012885 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 685727012886 LabA_like proteins; Region: LabA_like; cd06167 685727012887 putative metal binding site [ion binding]; other site 685727012888 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 685727012889 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 685727012890 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 685727012891 Predicted transcriptional regulator [Transcription]; Region: COG1959 685727012892 Transcriptional regulator; Region: Rrf2; pfam02082 685727012893 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727012894 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727012895 SnoaL-like domain; Region: SnoaL_2; pfam12680 685727012897 classical (c) SDRs; Region: SDR_c; cd05233 685727012898 NAD(P) binding site [chemical binding]; other site 685727012899 Uncharacterized conserved protein [Function unknown]; Region: COG2128 685727012900 Agrobacterium tumefaciens protein Atu4866; Region: Atu4866; pfam11512 685727012901 hypothetical protein; Provisional; Region: PRK08204 685727012902 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 685727012903 active site 685727012904 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 685727012905 Agrobacterium tumefaciens protein Atu4866; Region: Atu4866; pfam11512 685727012906 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 685727012907 salt bridge; other site 685727012908 non-specific DNA binding site [nucleotide binding]; other site 685727012909 sequence-specific DNA binding site [nucleotide binding]; other site 685727012910 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 685727012911 classical (c) SDRs; Region: SDR_c; cd05233 685727012912 NAD(P) binding site [chemical binding]; other site 685727012913 active site 685727012914 TniQ; Region: TniQ; pfam06527 685727012915 Transcriptional regulator [Transcription]; Region: LysR; COG0583 685727012916 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685727012917 AAA domain; Region: AAA_22; pfam13401 685727012918 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372 685727012919 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 685727012920 replicative DNA helicase; Region: DnaB; TIGR00665 685727012921 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 685727012922 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 685727012923 Walker A motif; other site 685727012924 ATP binding site [chemical binding]; other site 685727012925 Walker B motif; other site 685727012926 DNA binding loops [nucleotide binding] 685727012927 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 685727012928 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 685727012929 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 685727012930 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 685727012931 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 685727012932 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 685727012933 dimer interface [polypeptide binding]; other site 685727012934 ssDNA binding site [nucleotide binding]; other site 685727012935 tetramer (dimer of dimers) interface [polypeptide binding]; other site 685727012936 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 685727012937 Predicted integral membrane protein [Function unknown]; Region: COG5650 685727012938 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 685727012939 Predicted integral membrane protein [Function unknown]; Region: COG5650 685727012940 Transglycosylase; Region: Transgly; pfam00912 685727012941 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 685727012942 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 685727012943 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 685727012944 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 685727012945 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 685727012946 Predicted transcriptional regulators [Transcription]; Region: COG1695 685727012947 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 685727012948 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 685727012949 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 685727012950 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 685727012951 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685727012952 Walker A/P-loop; other site 685727012953 ATP binding site [chemical binding]; other site 685727012954 Q-loop/lid; other site 685727012955 ABC transporter signature motif; other site 685727012956 Walker B; other site 685727012957 D-loop; other site 685727012958 H-loop/switch region; other site 685727012959 ABC transporter; Region: ABC_tran_2; pfam12848 685727012960 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685727012961 Walker A/P-loop; other site 685727012962 ATP binding site [chemical binding]; other site 685727012963 ABC transporter; Region: ABC_tran; pfam00005 685727012964 Q-loop/lid; other site 685727012965 ABC transporter signature motif; other site 685727012966 Walker B; other site 685727012967 D-loop; other site 685727012968 short chain dehydrogenase; Provisional; Region: PRK08251 685727012969 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727012970 NAD(P) binding site [chemical binding]; other site 685727012971 active site 685727012972 Phosphotransferase enzyme family; Region: APH; pfam01636 685727012973 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 685727012974 putative active site [active] 685727012975 putative substrate binding site [chemical binding]; other site 685727012976 ATP binding site [chemical binding]; other site 685727012977 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 685727012978 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 685727012979 active site 685727012980 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727012981 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727012982 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 685727012983 Transglycosylase; Region: Transgly; pfam00912 685727012984 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 685727012985 Predicted transcriptional regulators [Transcription]; Region: COG1725 685727012986 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 685727012987 DNA-binding site [nucleotide binding]; DNA binding site 685727012988 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 685727012989 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685727012990 Walker A/P-loop; other site 685727012991 ATP binding site [chemical binding]; other site 685727012992 Q-loop/lid; other site 685727012993 ABC transporter signature motif; other site 685727012994 Walker B; other site 685727012995 D-loop; other site 685727012996 H-loop/switch region; other site 685727012997 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 685727012998 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 685727012999 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 685727013000 Transglycosylase; Region: Transgly; pfam00912 685727013001 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 685727013002 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 685727013003 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685727013004 dimer interface [polypeptide binding]; other site 685727013005 conserved gate region; other site 685727013006 putative PBP binding loops; other site 685727013007 ABC-ATPase subunit interface; other site 685727013008 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 685727013009 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685727013010 dimer interface [polypeptide binding]; other site 685727013011 conserved gate region; other site 685727013012 putative PBP binding loops; other site 685727013013 ABC-ATPase subunit interface; other site 685727013014 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 685727013015 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 685727013016 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 685727013017 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 685727013018 Walker A/P-loop; other site 685727013019 ATP binding site [chemical binding]; other site 685727013020 Q-loop/lid; other site 685727013021 ABC transporter signature motif; other site 685727013022 Walker B; other site 685727013023 D-loop; other site 685727013024 H-loop/switch region; other site 685727013025 TOBE domain; Region: TOBE_2; pfam08402 685727013026 Domain of unknown function (DUF385); Region: DUF385; cl04387 685727013027 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 685727013028 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 685727013029 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 685727013030 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 685727013031 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 685727013032 substrate binding pocket [chemical binding]; other site 685727013033 membrane-bound complex binding site; other site 685727013034 hinge residues; other site 685727013035 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 685727013036 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685727013037 dimer interface [polypeptide binding]; other site 685727013038 conserved gate region; other site 685727013039 putative PBP binding loops; other site 685727013040 ABC-ATPase subunit interface; other site 685727013041 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 685727013042 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 685727013043 Walker A/P-loop; other site 685727013044 ATP binding site [chemical binding]; other site 685727013045 Q-loop/lid; other site 685727013046 ABC transporter signature motif; other site 685727013047 Walker B; other site 685727013048 D-loop; other site 685727013049 H-loop/switch region; other site 685727013050 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 685727013051 CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427 685727013052 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 685727013053 DXD motif; other site 685727013054 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 685727013055 classical (c) SDRs; Region: SDR_c; cd05233 685727013056 NAD(P) binding site [chemical binding]; other site 685727013057 active site 685727013058 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 685727013059 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 685727013060 active site 685727013061 Alkaline and neutral invertase; Region: Glyco_hydro_100; cl17340 685727013062 hypothetical protein; Provisional; Region: PRK07945 685727013063 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 685727013064 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 685727013065 active site 685727013066 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 685727013067 Winged helix-turn helix; Region: HTH_29; pfam13551 685727013068 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 685727013069 putative Zn2+ binding site [ion binding]; other site 685727013070 putative DNA binding site [nucleotide binding]; other site 685727013071 short chain dehydrogenase; Provisional; Region: PRK08219 685727013072 classical (c) SDRs; Region: SDR_c; cd05233 685727013073 NAD(P) binding site [chemical binding]; other site 685727013074 active site 685727013075 HutD; Region: HutD; cl01532 685727013076 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 685727013077 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 685727013078 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 685727013079 intersubunit interface [polypeptide binding]; other site 685727013080 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 685727013081 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 685727013082 ABC-ATPase subunit interface; other site 685727013083 dimer interface [polypeptide binding]; other site 685727013084 putative PBP binding regions; other site 685727013085 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 685727013086 ABC-ATPase subunit interface; other site 685727013087 dimer interface [polypeptide binding]; other site 685727013088 putative PBP binding regions; other site 685727013089 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 685727013090 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 685727013091 Walker A/P-loop; other site 685727013092 ATP binding site [chemical binding]; other site 685727013093 Q-loop/lid; other site 685727013094 ABC transporter signature motif; other site 685727013095 Walker B; other site 685727013096 D-loop; other site 685727013097 H-loop/switch region; other site 685727013098 Secretory lipase; Region: LIP; pfam03583 685727013099 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 685727013100 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 685727013101 HIGH motif; other site 685727013102 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 685727013103 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 685727013104 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 685727013105 active site 685727013106 KMSKS motif; other site 685727013107 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 685727013108 tRNA binding surface [nucleotide binding]; other site 685727013109 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 685727013110 SdpI/YhfL protein family; Region: SdpI; pfam13630 685727013111 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 685727013112 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 685727013113 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 685727013114 dimerization interface [polypeptide binding]; other site 685727013115 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 685727013116 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 685727013117 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 685727013118 pyridoxal 5'-phosphate binding site [chemical binding]; other site 685727013119 catalytic residue [active] 685727013120 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 685727013121 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 685727013122 hypothetical protein; Validated; Region: PRK00228 685727013123 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 685727013124 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 685727013125 active site residue [active] 685727013126 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 685727013127 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 685727013128 NAD(P) binding site [chemical binding]; other site 685727013129 active site 685727013130 H+ Antiporter protein; Region: 2A0121; TIGR00900 685727013131 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 685727013132 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 685727013133 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 685727013134 Walker A/P-loop; other site 685727013135 ATP binding site [chemical binding]; other site 685727013136 Q-loop/lid; other site 685727013137 ABC transporter signature motif; other site 685727013138 Walker B; other site 685727013139 D-loop; other site 685727013140 H-loop/switch region; other site 685727013141 TOBE domain; Region: TOBE; cl01440 685727013142 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 685727013143 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 685727013144 dimer interface [polypeptide binding]; other site 685727013145 conserved gate region; other site 685727013146 putative PBP binding loops; other site 685727013147 ABC-ATPase subunit interface; other site 685727013148 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 685727013149 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 685727013150 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 685727013151 DNA binding residues [nucleotide binding] 685727013152 TOBE domain; Region: TOBE; cl01440 685727013153 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 685727013154 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 685727013155 active site 685727013156 NTP binding site [chemical binding]; other site 685727013157 metal binding triad [ion binding]; metal-binding site 685727013158 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 685727013159 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 685727013160 Zn2+ binding site [ion binding]; other site 685727013161 Mg2+ binding site [ion binding]; other site 685727013162 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 685727013163 active site 685727013164 Ap6A binding site [chemical binding]; other site 685727013165 nudix motif; other site 685727013166 metal binding site [ion binding]; metal-binding site 685727013167 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 685727013168 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 685727013169 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 685727013170 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 685727013171 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 685727013172 DNA binding residues [nucleotide binding] 685727013173 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 685727013174 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727013175 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 685727013176 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 685727013177 FtsX-like permease family; Region: FtsX; pfam02687 685727013178 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 685727013179 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 685727013180 Walker A/P-loop; other site 685727013181 ATP binding site [chemical binding]; other site 685727013182 Q-loop/lid; other site 685727013183 ABC transporter signature motif; other site 685727013184 Walker B; other site 685727013185 D-loop; other site 685727013186 H-loop/switch region; other site 685727013187 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 685727013188 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 685727013189 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 685727013190 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 685727013191 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 685727013192 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 685727013193 catalytic residues [active] 685727013194 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 685727013195 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 685727013196 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 685727013197 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 685727013198 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 685727013199 active site 685727013200 metal binding site [ion binding]; metal-binding site 685727013201 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 685727013202 ParB-like nuclease domain; Region: ParBc; pfam02195 685727013203 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 685727013204 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 685727013205 P-loop; other site 685727013206 Magnesium ion binding site [ion binding]; other site 685727013207 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 685727013208 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 685727013209 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 685727013210 S-adenosylmethionine binding site [chemical binding]; other site 685727013211 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 685727013212 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 685727013213 G-X-X-G motif; other site 685727013214 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 685727013215 RxxxH motif; other site 685727013216 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 685727013217 hypothetical protein; Validated; Region: PRK00041 685727013218 Ribonuclease P; Region: Ribonuclease_P; cl00457