-- dump date 20140620_025614 -- class Genbank::misc_feature -- table misc_feature_note -- id note 234621000001 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 234621000002 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 234621000003 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 234621000004 catalytic residues [active] 234621000005 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 234621000006 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234621000007 non-specific DNA binding site [nucleotide binding]; other site 234621000008 salt bridge; other site 234621000009 sequence-specific DNA binding site [nucleotide binding]; other site 234621000010 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234621000011 S-adenosylmethionine binding site [chemical binding]; other site 234621000012 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 234621000013 DEAD-like helicases superfamily; Region: DEXDc; smart00487 234621000014 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 234621000015 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 234621000016 nucleotide binding region [chemical binding]; other site 234621000017 ATP-binding site [chemical binding]; other site 234621000018 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 234621000019 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 234621000020 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 234621000021 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 234621000022 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 234621000023 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 234621000024 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 234621000025 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 234621000026 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 234621000027 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 234621000028 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 234621000029 HNH endonuclease; Region: HNH_3; pfam13392 234621000030 major vault protein; Provisional; Region: PTZ00491 234621000031 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 234621000032 TrwC relaxase; Region: TrwC; pfam08751 234621000033 AAA domain; Region: AAA_30; pfam13604 234621000034 Abi-like protein; Region: Abi_2; pfam07751 234621000035 Helix-turn-helix domain; Region: HTH_17; pfam12728 234621000036 Staphylococcal nuclease homologues; Region: SNc; smart00318 234621000037 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 234621000038 Catalytic site; other site 234621000039 Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550 234621000040 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 234621000041 active site 234621000042 putative interdomain interaction site [polypeptide binding]; other site 234621000043 putative metal-binding site [ion binding]; other site 234621000044 putative nucleotide binding site [chemical binding]; other site 234621000045 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 234621000046 domain I; other site 234621000047 DNA binding groove [nucleotide binding] 234621000048 phosphate binding site [ion binding]; other site 234621000049 domain II; other site 234621000050 domain III; other site 234621000051 nucleotide binding site [chemical binding]; other site 234621000052 catalytic site [active] 234621000053 domain IV; other site 234621000054 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 234621000055 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 234621000056 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 234621000057 N-acetyl-D-glucosamine binding site [chemical binding]; other site 234621000058 catalytic residue [active] 234621000059 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 234621000060 Peptidase family M23; Region: Peptidase_M23; pfam01551 234621000061 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 234621000062 N-acetyl-D-glucosamine binding site [chemical binding]; other site 234621000063 catalytic residue [active] 234621000064 AAA-like domain; Region: AAA_10; pfam12846 234621000065 Cutinase; Region: Cutinase; pfam01083 234621000066 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 234621000067 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234621000068 non-specific DNA binding site [nucleotide binding]; other site 234621000069 salt bridge; other site 234621000070 sequence-specific DNA binding site [nucleotide binding]; other site 234621000071 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 234621000072 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234621000073 salt bridge; other site 234621000074 non-specific DNA binding site [nucleotide binding]; other site 234621000075 sequence-specific DNA binding site [nucleotide binding]; other site 234621000076 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 234621000077 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621000078 NAD(P) binding site [chemical binding]; other site 234621000079 active site 234621000080 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 234621000081 Cytochrome P450; Region: p450; pfam00067 234621000082 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 234621000083 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 234621000084 P-loop; other site 234621000085 Magnesium ion binding site [ion binding]; other site 234621000086 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 234621000087 Magnesium ion binding site [ion binding]; other site 234621000088 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 234621000089 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621000090 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621000091 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 234621000092 active site 234621000093 catalytic residues [active] 234621000094 DNA binding site [nucleotide binding] 234621000095 Int/Topo IB signature motif; other site 234621000096 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 234621000097 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621000098 acyl-activating enzyme (AAE) consensus motif; other site 234621000099 AMP binding site [chemical binding]; other site 234621000100 active site 234621000101 CoA binding site [chemical binding]; other site 234621000102 enoyl-CoA hydratase; Provisional; Region: PRK06688 234621000103 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 234621000104 substrate binding site [chemical binding]; other site 234621000105 oxyanion hole (OAH) forming residues; other site 234621000106 trimer interface [polypeptide binding]; other site 234621000107 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 234621000108 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 234621000109 dimer interface [polypeptide binding]; other site 234621000110 active site 234621000111 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 234621000112 putative active site [active] 234621000113 putative catalytic site [active] 234621000114 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 234621000115 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 234621000116 NAD binding site [chemical binding]; other site 234621000117 homodimer interface [polypeptide binding]; other site 234621000118 homotetramer interface [polypeptide binding]; other site 234621000119 active site 234621000120 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621000121 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621000122 active site 234621000123 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 234621000124 enoyl-CoA hydratase; Provisional; Region: PRK08138 234621000125 substrate binding site [chemical binding]; other site 234621000126 oxyanion hole (OAH) forming residues; other site 234621000127 trimer interface [polypeptide binding]; other site 234621000128 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 234621000129 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 234621000130 dimer interface [polypeptide binding]; other site 234621000131 acyl-activating enzyme (AAE) consensus motif; other site 234621000132 putative active site [active] 234621000133 AMP binding site [chemical binding]; other site 234621000134 putative CoA binding site [chemical binding]; other site 234621000135 acetyl-CoA acetyltransferase; Provisional; Region: PRK06504 234621000136 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 234621000137 dimer interface [polypeptide binding]; other site 234621000138 active site 234621000139 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 234621000140 CoA-transferase family III; Region: CoA_transf_3; pfam02515 234621000141 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621000142 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621000143 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 234621000144 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 234621000145 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 234621000146 catalytic residues [active] 234621000147 catalytic nucleophile [active] 234621000148 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 234621000149 Presynaptic Site I dimer interface [polypeptide binding]; other site 234621000150 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 234621000151 Synaptic Flat tetramer interface [polypeptide binding]; other site 234621000152 Synaptic Site I dimer interface [polypeptide binding]; other site 234621000153 DNA binding site [nucleotide binding] 234621000154 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 234621000155 DNA-binding interface [nucleotide binding]; DNA binding site 234621000156 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 234621000157 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621000158 TAP-like protein; Region: Abhydrolase_4; pfam08386 234621000159 multiple promoter invertase; Provisional; Region: mpi; PRK13413 234621000160 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 234621000161 catalytic residues [active] 234621000162 catalytic nucleophile [active] 234621000163 Presynaptic Site I dimer interface [polypeptide binding]; other site 234621000164 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 234621000165 Synaptic Flat tetramer interface [polypeptide binding]; other site 234621000166 Synaptic Site I dimer interface [polypeptide binding]; other site 234621000167 DNA binding site [nucleotide binding] 234621000168 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 234621000169 DNA-binding interface [nucleotide binding]; DNA binding site 234621000170 ParB-like nuclease domain; Region: ParBc; pfam02195 234621000171 Replicase family; Region: Replicase; pfam03090 234621000172 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 234621000173 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 234621000174 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 234621000175 DNA binding residues [nucleotide binding] 234621000176 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 234621000177 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 234621000178 CHC2 zinc finger; Region: zf-CHC2; cl17510 234621000179 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 234621000180 active site 234621000181 metal binding site [ion binding]; metal-binding site 234621000182 interdomain interaction site; other site 234621000183 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 234621000184 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 234621000185 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 234621000186 Magnesium ion binding site [ion binding]; other site 234621000187 Cutinase; Region: Cutinase; pfam01083 234621000188 RNA polymerase sigma-70 factor, Rhodopirellula/Verrucomicrobium family; Region: Sig-70_gvs1; TIGR02989 234621000189 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 234621000190 AAA-like domain; Region: AAA_10; pfam12846 234621000191 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 234621000192 Peptidase family M23; Region: Peptidase_M23; pfam01551 234621000193 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 234621000194 NlpC/P60 family; Region: NLPC_P60; cl17555 234621000195 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 234621000196 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234621000197 Walker A motif; other site 234621000198 ATP binding site [chemical binding]; other site 234621000199 Walker B motif; other site 234621000200 arginine finger; other site 234621000201 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 234621000202 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 234621000203 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 234621000204 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234621000205 non-specific DNA binding site [nucleotide binding]; other site 234621000206 salt bridge; other site 234621000207 sequence-specific DNA binding site [nucleotide binding]; other site 234621000208 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234621000209 non-specific DNA binding site [nucleotide binding]; other site 234621000210 salt bridge; other site 234621000211 sequence-specific DNA binding site [nucleotide binding]; other site 234621000212 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621000213 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621000214 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 234621000215 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 234621000216 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234621000217 non-specific DNA binding site [nucleotide binding]; other site 234621000218 salt bridge; other site 234621000219 sequence-specific DNA binding site [nucleotide binding]; other site 234621000220 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234621000221 sequence-specific DNA binding site [nucleotide binding]; other site 234621000222 salt bridge; other site 234621000223 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 234621000224 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630 234621000225 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 234621000226 Walker A motif; other site 234621000227 ATP binding site [chemical binding]; other site 234621000228 Walker B motif; other site 234621000229 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 234621000230 TadE-like protein; Region: TadE; pfam07811 234621000231 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 234621000232 CAAX protease self-immunity; Region: Abi; pfam02517 234621000233 Bystin; Region: Bystin; pfam05291 234621000234 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 234621000235 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 234621000236 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 234621000237 A-kinase anchor protein 110 kDa (AKAP 110); Region: AKAP_110; cl14906 234621000238 Merozoite surface protein 1 (MSP1) C-terminus; Region: MSP1_C; pfam07462 234621000239 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 234621000240 NlpC/P60 family; Region: NLPC_P60; pfam00877 234621000241 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 234621000242 Active Sites [active] 234621000243 RAMP superfamily; Region: RAMPs; pfam03787 234621000244 Transcription factor WhiB; Region: Whib; pfam02467 234621000245 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 234621000246 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 234621000247 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 234621000248 active site 234621000249 catalytic residues [active] 234621000250 DNA binding site [nucleotide binding] 234621000251 Int/Topo IB signature motif; other site 234621000252 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 234621000253 active site 234621000254 catalytic residues [active] 234621000255 DNA binding site [nucleotide binding] 234621000256 Int/Topo IB signature motif; other site 234621000257 high affinity sulphate transporter 1; Region: sulP; TIGR00815 234621000258 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 234621000259 Sulfate transporter family; Region: Sulfate_transp; pfam00916 234621000260 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 234621000261 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 234621000262 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 234621000263 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 234621000264 DNA binding residues [nucleotide binding] 234621000265 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 234621000266 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 234621000267 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 234621000268 Sulfate transporter family; Region: Sulfate_transp; pfam00916 234621000269 Sulfate transporter family; Region: Sulfate_transp; pfam00916 234621000270 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 234621000271 Predicted membrane protein [Function unknown]; Region: COG4763 234621000272 Acyltransferase family; Region: Acyl_transf_3; pfam01757 234621000273 Predicted membrane protein [Function unknown]; Region: COG2246 234621000274 GtrA-like protein; Region: GtrA; pfam04138 234621000275 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621000276 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621000277 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 234621000278 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621000279 Major Facilitator Superfamily; Region: MFS_1; pfam07690 234621000280 putative substrate translocation pore; other site 234621000281 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621000282 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 234621000283 DNA binding site [nucleotide binding] 234621000284 active site 234621000285 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 234621000286 DNA binding site [nucleotide binding] 234621000287 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 234621000288 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 234621000289 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 234621000290 Major Facilitator Superfamily; Region: MFS_1; pfam07690 234621000291 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621000292 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 234621000293 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 234621000294 dimerization interface [polypeptide binding]; other site 234621000295 putative DNA binding site [nucleotide binding]; other site 234621000296 putative Zn2+ binding site [ion binding]; other site 234621000297 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 234621000298 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 234621000299 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 234621000300 Coenzyme A binding pocket [chemical binding]; other site 234621000301 conserved hypothetical integral membrane protein TIGR02206; Region: intg_mem_TP0381 234621000302 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 234621000303 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 234621000304 iron-sulfur cluster [ion binding]; other site 234621000305 [2Fe-2S] cluster binding site [ion binding]; other site 234621000306 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 234621000307 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 234621000308 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 234621000309 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 234621000310 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 234621000311 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 234621000312 Copper resistance protein D; Region: CopD; pfam05425 234621000313 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 234621000314 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 234621000315 Peptidase family M23; Region: Peptidase_M23; pfam01551 234621000316 Penicillinase repressor; Region: Pencillinase_R; pfam03965 234621000317 Peptidase family M48; Region: Peptidase_M48; cl12018 234621000318 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 234621000319 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 234621000320 D-pathway; other site 234621000321 Putative ubiquinol binding site [chemical binding]; other site 234621000322 Low-spin heme (heme b) binding site [chemical binding]; other site 234621000323 Putative water exit pathway; other site 234621000324 Binuclear center (heme o3/CuB) [ion binding]; other site 234621000325 K-pathway; other site 234621000326 Putative proton exit pathway; other site 234621000327 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 234621000328 putative active site [active] 234621000329 redox center [active] 234621000330 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 234621000331 Thioredoxin; Region: Thioredoxin_4; pfam13462 234621000332 CopC domain; Region: CopC; pfam04234 234621000333 WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266 234621000334 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 234621000335 Domain of unknown function (DUF305); Region: DUF305; pfam03713 234621000336 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 234621000337 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 234621000338 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 234621000339 putative active site [active] 234621000340 catalytic triad [active] 234621000341 putative dimer interface [polypeptide binding]; other site 234621000342 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 234621000343 ResB-like family; Region: ResB; pfam05140 234621000344 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 234621000345 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 234621000346 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 234621000347 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 234621000348 catalytic residues [active] 234621000349 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 234621000350 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 234621000351 catalytic residues [active] 234621000352 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 234621000353 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 234621000354 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 234621000355 motif II; other site 234621000356 MMPL family; Region: MMPL; pfam03176 234621000357 Domain of unknown function DUF302; Region: DUF302; pfam03625 234621000358 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 234621000359 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 234621000360 putative homotetramer interface [polypeptide binding]; other site 234621000361 putative homodimer interface [polypeptide binding]; other site 234621000362 putative allosteric switch controlling residues; other site 234621000363 putative metal binding site [ion binding]; other site 234621000364 putative homodimer-homodimer interface [polypeptide binding]; other site 234621000365 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 234621000366 Rhodanese-like domain; Region: Rhodanese; pfam00581 234621000367 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 234621000368 active site residue [active] 234621000369 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 234621000370 Cadmium resistance transporter; Region: Cad; pfam03596 234621000371 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 234621000372 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 234621000373 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 234621000374 Soluble P-type ATPase [General function prediction only]; Region: COG4087 234621000375 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 234621000376 dimerization interface [polypeptide binding]; other site 234621000377 putative DNA binding site [nucleotide binding]; other site 234621000378 putative Zn2+ binding site [ion binding]; other site 234621000379 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 234621000380 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 234621000381 DNA binding residues [nucleotide binding] 234621000382 dimer interface [polypeptide binding]; other site 234621000383 metal binding site [ion binding]; metal-binding site 234621000384 Helicase associated domain; Region: HA; pfam03457 234621000385 Helicase associated domain; Region: HA; pfam03457 234621000386 Helicase associated domain; Region: HA; pfam03457 234621000387 Helicase associated domain; Region: HA; pfam03457 234621000388 Helicase associated domain; Region: HA; pfam03457 234621000389 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 234621000390 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 234621000391 active site 234621000392 phosphorylation site [posttranslational modification] 234621000393 intermolecular recognition site; other site 234621000394 dimerization interface [polypeptide binding]; other site 234621000395 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 234621000396 DNA binding site [nucleotide binding] 234621000397 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 234621000398 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 234621000399 Walker A/P-loop; other site 234621000400 ATP binding site [chemical binding]; other site 234621000401 Q-loop/lid; other site 234621000402 ABC transporter signature motif; other site 234621000403 Walker B; other site 234621000404 D-loop; other site 234621000405 H-loop/switch region; other site 234621000406 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 234621000407 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234621000408 dimer interface [polypeptide binding]; other site 234621000409 conserved gate region; other site 234621000410 putative PBP binding loops; other site 234621000411 ABC-ATPase subunit interface; other site 234621000412 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 234621000413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234621000414 dimer interface [polypeptide binding]; other site 234621000415 conserved gate region; other site 234621000416 putative PBP binding loops; other site 234621000417 ABC-ATPase subunit interface; other site 234621000418 PBP superfamily domain; Region: PBP_like_2; cl17296 234621000419 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 234621000420 putative DNA binding site [nucleotide binding]; other site 234621000421 putative Zn2+ binding site [ion binding]; other site 234621000422 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 234621000423 Low molecular weight phosphatase family; Region: LMWPc; cl00105 234621000424 active site 234621000425 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 234621000426 Low molecular weight phosphatase family; Region: LMWPc; cd00115 234621000427 active site 234621000428 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 234621000429 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 234621000430 dimerization interface [polypeptide binding]; other site 234621000431 putative DNA binding site [nucleotide binding]; other site 234621000432 putative Zn2+ binding site [ion binding]; other site 234621000433 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 234621000434 arsenical-resistance protein; Region: acr3; TIGR00832 234621000435 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 234621000436 Low molecular weight phosphatase family; Region: LMWPc; cd00115 234621000437 active site 234621000438 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 234621000439 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 234621000440 Low molecular weight phosphatase family; Region: LMWPc; cl00105 234621000441 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 234621000442 active site 234621000443 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 234621000444 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 234621000445 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 234621000446 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 234621000447 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 234621000448 P loop; other site 234621000449 Nucleotide binding site [chemical binding]; other site 234621000450 DTAP/Switch II; other site 234621000451 Switch I; other site 234621000452 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 234621000453 P loop; other site 234621000454 Nucleotide binding site [chemical binding]; other site 234621000455 DTAP/Switch II; other site 234621000456 Switch I; other site 234621000457 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234621000458 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 234621000459 Walker A motif; other site 234621000460 ATP binding site [chemical binding]; other site 234621000461 Walker B motif; other site 234621000462 arginine finger; other site 234621000463 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 234621000464 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 234621000465 metal ion-dependent adhesion site (MIDAS); other site 234621000466 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 234621000467 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 234621000468 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 234621000469 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 234621000470 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 234621000471 Integrase core domain; Region: rve_3; cl15866 234621000472 Transposase; Region: DEDD_Tnp_IS110; pfam01548 234621000473 HTH-like domain; Region: HTH_21; pfam13276 234621000474 Secretory lipase; Region: LIP; pfam03583 234621000475 Transposase; Region: HTH_Tnp_1; cl17663 234621000476 HTH-like domain; Region: HTH_21; pfam13276 234621000477 Integrase core domain; Region: rve; pfam00665 234621000478 Winged helix-turn helix; Region: HTH_29; pfam13551 234621000479 HTH-like domain; Region: HTH_21; pfam13276 234621000480 HTH-like domain; Region: HTH_21; pfam13276 234621000481 Transposase; Region: DEDD_Tnp_IS110; pfam01548 234621000482 Transposase; Region: HTH_Tnp_1; pfam01527 234621000483 Integrase core domain; Region: rve_3; cl15866 234621000484 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 234621000485 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 234621000486 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 234621000487 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 234621000488 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 234621000489 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234621000490 Walker A motif; other site 234621000491 ATP binding site [chemical binding]; other site 234621000492 Walker B motif; other site 234621000493 Integrase core domain; Region: rve; pfam00665 234621000494 Integrase core domain; Region: rve_3; cl15866 234621000495 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 234621000496 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 234621000497 Integrase core domain; Region: rve; pfam00665 234621000498 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 234621000499 Integrase core domain; Region: rve; pfam00665 234621000500 transposase/IS protein; Provisional; Region: PRK09183 234621000501 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234621000502 Walker A motif; other site 234621000503 ATP binding site [chemical binding]; other site 234621000504 Walker B motif; other site 234621000505 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 234621000506 HTH-like domain; Region: HTH_21; pfam13276 234621000507 Transposase; Region: HTH_Tnp_1; cl17663 234621000508 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 234621000509 structural tetrad; other site 234621000510 FOG: WD40 repeat [General function prediction only]; Region: COG2319 234621000511 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 234621000512 structural tetrad; other site 234621000513 Integrase core domain; Region: rve_3; pfam13683 234621000514 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 234621000515 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 234621000516 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 234621000517 putative homotetramer interface [polypeptide binding]; other site 234621000518 putative homodimer interface [polypeptide binding]; other site 234621000519 putative allosteric switch controlling residues; other site 234621000520 putative metal binding site [ion binding]; other site 234621000521 putative homodimer-homodimer interface [polypeptide binding]; other site 234621000522 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 234621000523 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 234621000524 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 234621000525 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 234621000526 active site residue [active] 234621000527 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 234621000528 active site residue [active] 234621000529 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 234621000530 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 234621000531 DNA-binding site [nucleotide binding]; DNA binding site 234621000532 UTRA domain; Region: UTRA; pfam07702 234621000533 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 234621000534 active site residue [active] 234621000535 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 234621000536 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 234621000537 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 234621000538 D-pathway; other site 234621000539 Putative ubiquinol binding site [chemical binding]; other site 234621000540 Low-spin heme (heme b) binding site [chemical binding]; other site 234621000541 Putative water exit pathway; other site 234621000542 Binuclear center (heme o3/CuB) [ion binding]; other site 234621000543 K-pathway; other site 234621000544 Putative proton exit pathway; other site 234621000545 RNA polymerase sigma-70 factor, Rhodopirellula/Verrucomicrobium family; Region: Sig-70_gvs1; TIGR02989 234621000546 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234621000547 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 234621000548 DNA binding residues [nucleotide binding] 234621000549 Putative zinc-finger; Region: zf-HC2; pfam13490 234621000550 Domain of unknown function DUF302; Region: DUF302; cl01364 234621000551 Thioredoxin; Region: Thioredoxin_4; pfam13462 234621000552 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 234621000553 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 234621000554 DsrE/DsrF-like family; Region: DrsE; cl00672 234621000555 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234621000556 S-adenosylmethionine binding site [chemical binding]; other site 234621000557 Integrase core domain; Region: rve; pfam00665 234621000558 Integrase core domain; Region: rve_2; pfam13333 234621000559 Integrase core domain; Region: rve_3; cl15866 234621000560 Integrase core domain; Region: rve; pfam00665 234621000561 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 234621000562 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 234621000563 CoenzymeA binding site [chemical binding]; other site 234621000564 subunit interaction site [polypeptide binding]; other site 234621000565 PHB binding site; other site 234621000566 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 234621000567 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621000568 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621000569 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621000570 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621000571 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621000572 Transposase; Region: HTH_Tnp_1; cl17663 234621000573 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 234621000574 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 234621000575 Integrase core domain; Region: rve; pfam00665 234621000576 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 234621000577 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 234621000578 Transposase; Region: DEDD_Tnp_IS110; pfam01548 234621000579 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 234621000580 Integrase core domain; Region: rve; pfam00665 234621000581 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 234621000582 Helix-turn-helix domain; Region: HTH_38; pfam13936 234621000583 Transposase; Region: HTH_Tnp_1; cl17663 234621000584 Integrase core domain; Region: rve; pfam00665 234621000585 Integrase core domain; Region: rve_2; pfam13333 234621000586 SCP-2 sterol transfer family; Region: SCP2; pfam02036 234621000587 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 234621000588 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 234621000589 dimer interface [polypeptide binding]; other site 234621000590 acyl-activating enzyme (AAE) consensus motif; other site 234621000591 putative active site [active] 234621000592 AMP binding site [chemical binding]; other site 234621000593 putative CoA binding site [chemical binding]; other site 234621000594 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 234621000595 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 234621000596 NAD binding site [chemical binding]; other site 234621000597 catalytic Zn binding site [ion binding]; other site 234621000598 substrate binding site [chemical binding]; other site 234621000599 structural Zn binding site [ion binding]; other site 234621000600 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 234621000601 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 234621000602 NAD(P) binding site [chemical binding]; other site 234621000603 catalytic residues [active] 234621000604 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 234621000605 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 234621000606 catalytic loop [active] 234621000607 iron binding site [ion binding]; other site 234621000608 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 234621000609 Cytochrome P450; Region: p450; cl12078 234621000610 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 234621000611 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 234621000612 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 234621000613 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 234621000614 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 234621000615 putative active site [active] 234621000616 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 234621000617 CoenzymeA binding site [chemical binding]; other site 234621000618 subunit interaction site [polypeptide binding]; other site 234621000619 PHB binding site; other site 234621000620 transposase/IS protein; Provisional; Region: PRK09183 234621000621 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234621000622 Walker A motif; other site 234621000623 ATP binding site [chemical binding]; other site 234621000624 Walker B motif; other site 234621000625 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 234621000626 Integrase core domain; Region: rve; pfam00665 234621000627 putative transposase OrfB; Reviewed; Region: PHA02517 234621000628 HTH-like domain; Region: HTH_21; pfam13276 234621000629 Integrase core domain; Region: rve; pfam00665 234621000630 Integrase core domain; Region: rve_3; pfam13683 234621000631 Transposase; Region: DEDD_Tnp_IS110; pfam01548 234621000632 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 234621000633 putative transposase OrfB; Reviewed; Region: PHA02517 234621000634 HTH-like domain; Region: HTH_21; pfam13276 234621000635 Integrase core domain; Region: rve; pfam00665 234621000636 Integrase core domain; Region: rve_3; pfam13683 234621000637 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 234621000638 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 234621000639 Presynaptic Site I dimer interface [polypeptide binding]; other site 234621000640 catalytic residues [active] 234621000641 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 234621000642 Synaptic Flat tetramer interface [polypeptide binding]; other site 234621000643 Synaptic Site I dimer interface [polypeptide binding]; other site 234621000644 DNA binding site [nucleotide binding] 234621000645 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 234621000646 Transposase; Region: DDE_Tnp_ISL3; pfam01610 234621000647 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621000648 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621000649 active site 234621000650 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621000651 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621000652 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 234621000653 CoenzymeA binding site [chemical binding]; other site 234621000654 subunit interaction site [polypeptide binding]; other site 234621000655 PHB binding site; other site 234621000656 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 234621000657 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 234621000658 putative acyl-acceptor binding pocket; other site 234621000659 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 234621000660 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 234621000661 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 234621000662 Transposase; Region: DEDD_Tnp_IS110; pfam01548 234621000663 Integrase core domain; Region: rve_3; cl15866 234621000664 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 234621000665 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 234621000666 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 234621000667 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 234621000668 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 234621000669 catalytic loop [active] 234621000670 iron binding site [ion binding]; other site 234621000671 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 234621000672 Cytochrome P450; Region: p450; cl12078 234621000673 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 234621000674 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 234621000675 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 234621000676 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05620 234621000677 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621000678 Integrase core domain; Region: rve; pfam00665 234621000679 Integrase core domain; Region: rve; pfam00665 234621000680 Integrase core domain; Region: rve_3; pfam13683 234621000681 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 234621000682 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 234621000683 active site 234621000684 DNA binding site [nucleotide binding] 234621000685 Int/Topo IB signature motif; other site 234621000686 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 234621000687 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 234621000688 active site 234621000689 catalytic residues [active] 234621000690 DNA binding site [nucleotide binding] 234621000691 Int/Topo IB signature motif; other site 234621000692 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 234621000693 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 234621000694 Pyridoxamine-phosphate oxidase [Coenzyme metabolism]; Region: PdxH; COG0259 234621000695 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 234621000696 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 234621000697 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 234621000698 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234621000699 Walker A motif; other site 234621000700 ATP binding site [chemical binding]; other site 234621000701 Walker B motif; other site 234621000702 arginine finger; other site 234621000703 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 234621000704 DnaA box-binding interface [nucleotide binding]; other site 234621000705 DNA polymerase III subunit beta; Validated; Region: PRK07761 234621000706 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 234621000707 putative DNA binding surface [nucleotide binding]; other site 234621000708 dimer interface [polypeptide binding]; other site 234621000709 beta-clamp/clamp loader binding surface; other site 234621000710 beta-clamp/translesion DNA polymerase binding surface; other site 234621000711 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 234621000712 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 234621000713 recombination protein F; Reviewed; Region: recF; PRK00064 234621000714 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 234621000715 Walker A/P-loop; other site 234621000716 ATP binding site [chemical binding]; other site 234621000717 Q-loop/lid; other site 234621000718 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234621000719 ABC transporter signature motif; other site 234621000720 Walker B; other site 234621000721 D-loop; other site 234621000722 H-loop/switch region; other site 234621000723 hypothetical protein; Provisional; Region: PRK03195 234621000724 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 234621000725 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 234621000726 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 234621000727 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 234621000728 FMN-binding pocket [chemical binding]; other site 234621000729 flavin binding motif; other site 234621000730 phosphate binding motif [ion binding]; other site 234621000731 beta-alpha-beta structure motif; other site 234621000732 NAD binding pocket [chemical binding]; other site 234621000733 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 234621000734 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 234621000735 catalytic loop [active] 234621000736 iron binding site [ion binding]; other site 234621000737 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 234621000738 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 234621000739 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234621000740 ATP binding site [chemical binding]; other site 234621000741 Mg2+ binding site [ion binding]; other site 234621000742 G-X-G motif; other site 234621000743 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 234621000744 anchoring element; other site 234621000745 dimer interface [polypeptide binding]; other site 234621000746 ATP binding site [chemical binding]; other site 234621000747 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 234621000748 active site 234621000749 putative metal-binding site [ion binding]; other site 234621000750 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 234621000751 DNA gyrase subunit A; Validated; Region: PRK05560 234621000752 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 234621000753 CAP-like domain; other site 234621000754 active site 234621000755 primary dimer interface [polypeptide binding]; other site 234621000756 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 234621000757 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 234621000758 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 234621000759 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 234621000760 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 234621000761 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 234621000762 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 234621000763 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 234621000764 Predicted membrane protein [Function unknown]; Region: COG4425 234621000765 Secretory lipase; Region: LIP; pfam03583 234621000766 Secretory lipase; Region: LIP; pfam03583 234621000767 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 234621000768 active site 234621000769 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 234621000770 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 234621000771 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621000772 putative substrate translocation pore; other site 234621000773 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 234621000774 GAF domain; Region: GAF; pfam01590 234621000775 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 234621000776 FAD binding domain; Region: FAD_binding_4; pfam01565 234621000777 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 234621000778 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 234621000779 active site 234621000780 iron coordination sites [ion binding]; other site 234621000781 substrate binding pocket [chemical binding]; other site 234621000782 putative septation inhibitor protein; Reviewed; Region: PRK00159 234621000783 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 234621000784 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 234621000785 Glutamine amidotransferase class-I; Region: GATase; pfam00117 234621000786 glutamine binding [chemical binding]; other site 234621000787 catalytic triad [active] 234621000788 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 234621000789 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234621000790 active site 234621000791 ATP binding site [chemical binding]; other site 234621000792 substrate binding site [chemical binding]; other site 234621000793 activation loop (A-loop); other site 234621000794 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 234621000795 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 234621000796 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 234621000797 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 234621000798 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 234621000799 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 234621000800 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234621000801 active site 234621000802 ATP binding site [chemical binding]; other site 234621000803 substrate binding site [chemical binding]; other site 234621000804 activation loop (A-loop); other site 234621000805 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 234621000806 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 234621000807 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 234621000808 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 234621000809 active site 234621000810 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 234621000811 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 234621000812 phosphopeptide binding site; other site 234621000813 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 234621000814 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 234621000815 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 234621000816 phosphopeptide binding site; other site 234621000817 transposase/IS protein; Provisional; Region: PRK09183 234621000818 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234621000819 Walker A motif; other site 234621000820 ATP binding site [chemical binding]; other site 234621000821 Walker B motif; other site 234621000822 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 234621000823 Integrase core domain; Region: rve; pfam00665 234621000824 Tyrosine kinase, catalytic domain; Region: TyrKc; smart00219 234621000825 Catalytic domain of Protein Kinases; Region: PKc; cd00180 234621000826 active site 234621000827 ATP binding site [chemical binding]; other site 234621000828 substrate binding site [chemical binding]; other site 234621000829 activation loop (A-loop); other site 234621000830 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 234621000831 N-glycosylase/DNA lyase; Provisional; Region: PRK01229 234621000832 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 234621000833 DNA methylase; Region: N6_N4_Mtase; pfam01555 234621000834 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 234621000835 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234621000836 Walker A motif; other site 234621000837 ATP binding site [chemical binding]; other site 234621000838 Walker B motif; other site 234621000839 arginine finger; other site 234621000840 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 234621000841 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 234621000842 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 234621000843 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 234621000844 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 234621000845 active site 234621000846 dimer interface [polypeptide binding]; other site 234621000847 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 234621000848 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 234621000849 active site 234621000850 FMN binding site [chemical binding]; other site 234621000851 substrate binding site [chemical binding]; other site 234621000852 3Fe-4S cluster binding site [ion binding]; other site 234621000853 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 234621000854 domain interface; other site 234621000855 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 234621000856 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 234621000857 Cutinase; Region: Cutinase; pfam01083 234621000858 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 234621000859 generic binding surface I; other site 234621000860 generic binding surface II; other site 234621000861 short chain dehydrogenase; Provisional; Region: PRK07832 234621000862 classical (c) SDRs; Region: SDR_c; cd05233 234621000863 NAD(P) binding site [chemical binding]; other site 234621000864 active site 234621000865 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 234621000866 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 234621000867 alpha-ketoglutarate dehydrogenase; Region: AKGDH_not_PDH; TIGR03186 234621000868 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 234621000869 TPP-binding site [chemical binding]; other site 234621000870 PYR/PP interface [polypeptide binding]; other site 234621000871 dimer interface [polypeptide binding]; other site 234621000872 TPP binding site [chemical binding]; other site 234621000873 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 234621000874 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 234621000875 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 234621000876 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 234621000877 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 234621000878 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 234621000879 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 234621000880 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234621000881 dimer interface [polypeptide binding]; other site 234621000882 conserved gate region; other site 234621000883 putative PBP binding loops; other site 234621000884 ABC-ATPase subunit interface; other site 234621000885 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 234621000886 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234621000887 dimer interface [polypeptide binding]; other site 234621000888 conserved gate region; other site 234621000889 putative PBP binding loops; other site 234621000890 ABC-ATPase subunit interface; other site 234621000891 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 234621000892 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 234621000893 Walker A/P-loop; other site 234621000894 ATP binding site [chemical binding]; other site 234621000895 Q-loop/lid; other site 234621000896 ABC transporter signature motif; other site 234621000897 Walker B; other site 234621000898 D-loop; other site 234621000899 H-loop/switch region; other site 234621000900 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 234621000901 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 234621000902 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 234621000903 Walker A/P-loop; other site 234621000904 ATP binding site [chemical binding]; other site 234621000905 Q-loop/lid; other site 234621000906 ABC transporter signature motif; other site 234621000907 Walker B; other site 234621000908 D-loop; other site 234621000909 H-loop/switch region; other site 234621000910 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 234621000911 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 234621000912 catalytic core [active] 234621000913 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 234621000914 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 234621000915 metal binding site [ion binding]; metal-binding site 234621000916 active site 234621000917 I-site; other site 234621000918 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 234621000919 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 234621000920 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 234621000921 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 234621000922 dimer interface [polypeptide binding]; other site 234621000923 putative anticodon binding site; other site 234621000924 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 234621000925 motif 1; other site 234621000926 dimer interface [polypeptide binding]; other site 234621000927 active site 234621000928 motif 2; other site 234621000929 motif 3; other site 234621000930 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 234621000931 RNA binding surface [nucleotide binding]; other site 234621000932 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 234621000933 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 234621000934 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621000935 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621000936 Phosphotransferase enzyme family; Region: APH; pfam01636 234621000937 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 234621000938 putative active site [active] 234621000939 putative substrate binding site [chemical binding]; other site 234621000940 ATP binding site [chemical binding]; other site 234621000941 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 234621000942 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 234621000943 putative acetyltransferase; Provisional; Region: PRK03624 234621000944 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 234621000945 Coenzyme A binding pocket [chemical binding]; other site 234621000946 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 234621000947 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 234621000948 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234621000949 salt bridge; other site 234621000950 non-specific DNA binding site [nucleotide binding]; other site 234621000951 sequence-specific DNA binding site [nucleotide binding]; other site 234621000952 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 234621000953 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 234621000954 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 234621000955 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 234621000956 acyl-activating enzyme (AAE) consensus motif; other site 234621000957 putative AMP binding site [chemical binding]; other site 234621000958 putative active site [active] 234621000959 putative CoA binding site [chemical binding]; other site 234621000960 Putative cyclase; Region: Cyclase; pfam04199 234621000961 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 234621000962 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234621000963 non-specific DNA binding site [nucleotide binding]; other site 234621000964 salt bridge; other site 234621000965 sequence-specific DNA binding site [nucleotide binding]; other site 234621000966 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621000967 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621000968 myosin-cross-reactive antigen; Provisional; Region: PRK13977 234621000969 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 234621000970 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 234621000971 conserved cys residue [active] 234621000972 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 234621000973 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 234621000974 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621000975 Major Facilitator Superfamily; Region: MFS_1; pfam07690 234621000976 putative substrate translocation pore; other site 234621000977 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 234621000978 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 234621000979 NAD(P) binding site [chemical binding]; other site 234621000980 catalytic residues [active] 234621000981 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 234621000982 hydrophobic ligand binding site; other site 234621000983 Proline dehydrogenase; Region: Pro_dh; cl03282 234621000984 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 234621000985 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 234621000986 FAD binding pocket [chemical binding]; other site 234621000987 FAD binding motif [chemical binding]; other site 234621000988 phosphate binding motif [ion binding]; other site 234621000989 NAD binding pocket [chemical binding]; other site 234621000990 Domain of unknown function (DUF222); Region: DUF222; pfam02720 234621000991 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 234621000992 active site 234621000993 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 234621000994 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234621000995 active site 234621000996 phosphorylation site [posttranslational modification] 234621000997 intermolecular recognition site; other site 234621000998 dimerization interface [polypeptide binding]; other site 234621000999 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 234621001000 DNA binding residues [nucleotide binding] 234621001001 dimerization interface [polypeptide binding]; other site 234621001002 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 234621001003 Histidine kinase; Region: HisKA_3; pfam07730 234621001004 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234621001005 ATP binding site [chemical binding]; other site 234621001006 Mg2+ binding site [ion binding]; other site 234621001007 G-X-G motif; other site 234621001008 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 234621001009 FtsX-like permease family; Region: FtsX; pfam02687 234621001010 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 234621001011 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 234621001012 Walker A/P-loop; other site 234621001013 ATP binding site [chemical binding]; other site 234621001014 Q-loop/lid; other site 234621001015 ABC transporter signature motif; other site 234621001016 Walker B; other site 234621001017 D-loop; other site 234621001018 H-loop/switch region; other site 234621001019 PAS domain; Region: PAS; smart00091 234621001020 PAS domain; Region: PAS_9; pfam13426 234621001021 putative active site [active] 234621001022 heme pocket [chemical binding]; other site 234621001023 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621001024 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621001025 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621001026 NAD(P) binding site [chemical binding]; other site 234621001027 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 234621001028 YcaO-like family; Region: YcaO; pfam02624 234621001029 YcaO-like family; Region: YcaO; pfam02624 234621001030 Predicted acyl esterases [General function prediction only]; Region: COG2936 234621001031 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 234621001032 H+ Antiporter protein; Region: 2A0121; TIGR00900 234621001033 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 234621001034 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 234621001035 ABC-ATPase subunit interface; other site 234621001036 dimer interface [polypeptide binding]; other site 234621001037 putative PBP binding regions; other site 234621001038 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 234621001039 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 234621001040 Walker A/P-loop; other site 234621001041 ATP binding site [chemical binding]; other site 234621001042 Q-loop/lid; other site 234621001043 ABC transporter signature motif; other site 234621001044 Walker B; other site 234621001045 D-loop; other site 234621001046 H-loop/switch region; other site 234621001047 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 234621001048 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 234621001049 intersubunit interface [polypeptide binding]; other site 234621001050 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 234621001051 putative FMN binding site [chemical binding]; other site 234621001052 Short C-terminal domain; Region: SHOCT; pfam09851 234621001053 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621001054 putative substrate translocation pore; other site 234621001055 Protein of unknown function (DUF664); Region: DUF664; pfam04978 234621001056 Predicted membrane protein [Function unknown]; Region: COG1288 234621001057 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 234621001058 hypothetical protein; Provisional; Region: PRK07907 234621001059 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 234621001060 active site 234621001061 metal binding site [ion binding]; metal-binding site 234621001062 dimer interface [polypeptide binding]; other site 234621001063 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621001064 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621001065 acyl-CoA synthetase; Validated; Region: PRK06178 234621001066 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621001067 acyl-activating enzyme (AAE) consensus motif; other site 234621001068 AMP binding site [chemical binding]; other site 234621001069 active site 234621001070 CoA binding site [chemical binding]; other site 234621001071 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 234621001072 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 234621001073 ATP-grasp domain; Region: ATP-grasp_4; cl17255 234621001074 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 234621001075 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 234621001076 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 234621001077 carboxyltransferase (CT) interaction site; other site 234621001078 biotinylation site [posttranslational modification]; other site 234621001079 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 234621001080 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 234621001081 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 234621001082 Sulfatase; Region: Sulfatase; pfam00884 234621001083 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 234621001084 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 234621001085 CysD dimerization site [polypeptide binding]; other site 234621001086 G1 box; other site 234621001087 putative GEF interaction site [polypeptide binding]; other site 234621001088 GTP/Mg2+ binding site [chemical binding]; other site 234621001089 Switch I region; other site 234621001090 G2 box; other site 234621001091 G3 box; other site 234621001092 Switch II region; other site 234621001093 G4 box; other site 234621001094 G5 box; other site 234621001095 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 234621001096 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 234621001097 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 234621001098 ligand-binding site [chemical binding]; other site 234621001099 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 234621001100 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 234621001101 Active Sites [active] 234621001102 Stf0 sulphotransferase; Region: Sulphotransf; pfam09037 234621001103 Copper resistance protein D; Region: CopD; pfam05425 234621001104 CopC domain; Region: CopC; pfam04234 234621001105 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 234621001106 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 234621001107 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 234621001108 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 234621001109 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 234621001110 metal binding site [ion binding]; metal-binding site 234621001111 active site 234621001112 I-site; other site 234621001113 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 234621001114 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 234621001115 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621001116 NAD(P) binding site [chemical binding]; other site 234621001117 active site 234621001118 Domain of unknown function (DUF222); Region: DUF222; pfam02720 234621001119 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 234621001120 active site 234621001121 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 234621001122 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 234621001123 Coenzyme A binding pocket [chemical binding]; other site 234621001124 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621001125 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621001126 lipid-transfer protein; Provisional; Region: PRK08256 234621001127 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 234621001128 active site 234621001129 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 234621001130 hydrophobic ligand binding site; other site 234621001131 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 234621001132 active site 234621001133 catalytic site [active] 234621001134 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 234621001135 active site 2 [active] 234621001136 active site 1 [active] 234621001137 short chain dehydrogenase; Provisional; Region: PRK07791 234621001138 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621001139 NAD(P) binding site [chemical binding]; other site 234621001140 active site 234621001141 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621001142 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621001143 active site 234621001144 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621001145 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621001146 active site 234621001147 amidase; Provisional; Region: PRK07869 234621001148 Amidase; Region: Amidase; cl11426 234621001149 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 234621001150 Transcriptional regulators [Transcription]; Region: FadR; COG2186 234621001151 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 234621001152 DNA-binding site [nucleotide binding]; DNA binding site 234621001153 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 234621001154 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 234621001155 intersubunit interface [polypeptide binding]; other site 234621001156 Helix-turn-helix domain; Region: HTH_18; pfam12833 234621001157 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 234621001158 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 234621001159 intersubunit interface [polypeptide binding]; other site 234621001160 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 234621001161 Amidase; Region: Amidase; cl11426 234621001162 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 234621001163 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 234621001164 metal binding site [ion binding]; metal-binding site 234621001165 putative dimer interface [polypeptide binding]; other site 234621001166 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621001167 D-galactonate transporter; Region: 2A0114; TIGR00893 234621001168 putative substrate translocation pore; other site 234621001169 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 234621001170 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 234621001171 AsnC family; Region: AsnC_trans_reg; pfam01037 234621001172 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 234621001173 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 234621001174 Predicted membrane protein [Function unknown]; Region: COG2119 234621001175 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 234621001176 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 234621001177 Uncharacterized conserved protein [Function unknown]; Region: COG5361 234621001178 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 234621001179 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 234621001180 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 234621001181 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 234621001182 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 234621001183 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 234621001184 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 234621001185 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 234621001186 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 234621001187 methionine sulfoxide reductase A; Provisional; Region: PRK00058 234621001188 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 234621001189 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 234621001190 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 234621001191 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 234621001192 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 234621001193 active site 234621001194 catalytic site [active] 234621001195 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 234621001196 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 234621001197 Ferritin-like domain; Region: Ferritin; pfam00210 234621001198 ferroxidase diiron center [ion binding]; other site 234621001199 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 234621001200 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 234621001201 Peptidase family M23; Region: Peptidase_M23; pfam01551 234621001202 Penicillinase repressor; Region: Pencillinase_R; pfam03965 234621001203 Peptidase family M48; Region: Peptidase_M48; cl12018 234621001204 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 234621001205 Thioredoxin; Region: Thioredoxin_4; pfam13462 234621001206 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 234621001207 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 234621001208 Ferritin-like domain; Region: Ferritin; pfam00210 234621001209 ferroxidase diiron center [ion binding]; other site 234621001210 Transcriptional regulator [Transcription]; Region: LytR; COG1316 234621001211 CAAX protease self-immunity; Region: Abi; pfam02517 234621001212 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 234621001213 prephenate dehydratase; Provisional; Region: PRK11898 234621001214 Prephenate dehydratase; Region: PDT; pfam00800 234621001215 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 234621001216 putative L-Phe binding site [chemical binding]; other site 234621001217 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 234621001218 catalytic core [active] 234621001219 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 234621001220 EspG family; Region: ESX-1_EspG; pfam14011 234621001221 PPE family; Region: PPE; pfam00823 234621001222 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 234621001223 Septum formation; Region: Septum_form; pfam13845 234621001224 Septum formation; Region: Septum_form; pfam13845 234621001225 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 234621001226 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 234621001227 seryl-tRNA synthetase; Provisional; Region: PRK05431 234621001228 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 234621001229 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 234621001230 dimer interface [polypeptide binding]; other site 234621001231 active site 234621001232 motif 1; other site 234621001233 motif 2; other site 234621001234 motif 3; other site 234621001235 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 234621001236 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 234621001237 putative acyl-acceptor binding pocket; other site 234621001238 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 234621001239 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 234621001240 putative acyl-acceptor binding pocket; other site 234621001241 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 234621001242 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 234621001243 active site 234621001244 motif I; other site 234621001245 motif II; other site 234621001246 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 234621001247 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 234621001248 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 234621001249 amidase catalytic site [active] 234621001250 Zn binding residues [ion binding]; other site 234621001251 substrate binding site [chemical binding]; other site 234621001252 LGFP repeat; Region: LGFP; pfam08310 234621001253 Stage II sporulation protein; Region: SpoIID; pfam08486 234621001254 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 234621001255 LGFP repeat; Region: LGFP; pfam08310 234621001256 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 234621001257 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 234621001258 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 234621001259 Spore germination protein; Region: Spore_permease; cl17796 234621001260 putative acyltransferase; Provisional; Region: PRK05790 234621001261 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 234621001262 dimer interface [polypeptide binding]; other site 234621001263 active site 234621001264 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621001265 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621001266 active site 234621001267 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 234621001268 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 234621001269 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 234621001270 UDP-galactopyranose mutase; Region: GLF; pfam03275 234621001271 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 234621001272 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 234621001273 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 234621001274 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 234621001275 Putative esterase; Region: Esterase; pfam00756 234621001276 S-formylglutathione hydrolase; Region: PLN02442 234621001277 Putative esterase; Region: Esterase; pfam00756 234621001278 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 234621001279 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 234621001280 LGFP repeat; Region: LGFP; pfam08310 234621001281 LGFP repeat; Region: LGFP; pfam08310 234621001282 LGFP repeat; Region: LGFP; pfam08310 234621001283 Cutinase; Region: Cutinase; pfam01083 234621001284 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 234621001285 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 234621001286 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 234621001287 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 234621001288 acyl-activating enzyme (AAE) consensus motif; other site 234621001289 active site 234621001290 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 234621001291 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 234621001292 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 234621001293 active site 234621001294 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 234621001295 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 234621001296 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 234621001297 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 234621001298 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 234621001299 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 234621001300 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 234621001301 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835 234621001302 Transcriptional regulator [Transcription]; Region: LysR; COG0583 234621001303 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 234621001304 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 234621001305 putative dimerization interface [polypeptide binding]; other site 234621001306 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 234621001307 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 234621001308 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234621001309 sequence-specific DNA binding site [nucleotide binding]; other site 234621001310 salt bridge; other site 234621001311 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 234621001312 active site 234621001313 MspA; Region: MspA; pfam09203 234621001314 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621001315 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 234621001316 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 234621001317 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 234621001318 classical (c) SDRs; Region: SDR_c; cd05233 234621001319 NAD(P) binding site [chemical binding]; other site 234621001320 active site 234621001321 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 234621001322 FAD binding domain; Region: FAD_binding_4; pfam01565 234621001323 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 234621001324 Predicted membrane protein [Function unknown]; Region: COG2246 234621001325 GtrA-like protein; Region: GtrA; pfam04138 234621001326 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 234621001327 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 234621001328 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621001329 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621001330 Putative cyclase; Region: Cyclase; pfam04199 234621001331 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 234621001332 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 234621001333 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 234621001334 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 234621001335 active site 234621001336 acyl-CoA synthetase; Validated; Region: PRK06188 234621001337 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621001338 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 234621001339 acyl-activating enzyme (AAE) consensus motif; other site 234621001340 acyl-activating enzyme (AAE) consensus motif; other site 234621001341 putative AMP binding site [chemical binding]; other site 234621001342 putative active site [active] 234621001343 putative CoA binding site [chemical binding]; other site 234621001344 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 234621001345 ATP-grasp domain; Region: ATP-grasp_4; cl17255 234621001346 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 234621001347 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 234621001348 protein binding site [polypeptide binding]; other site 234621001349 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 234621001350 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 234621001351 active site 234621001352 Predicted membrane protein [Function unknown]; Region: COG2246 234621001353 GtrA-like protein; Region: GtrA; pfam04138 234621001354 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 234621001355 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 234621001356 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 234621001357 substrate binding site; other site 234621001358 tetramer interface; other site 234621001359 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 234621001360 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 234621001361 NAD binding site [chemical binding]; other site 234621001362 substrate binding site [chemical binding]; other site 234621001363 homodimer interface [polypeptide binding]; other site 234621001364 active site 234621001365 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 234621001366 extended (e) SDRs; Region: SDR_e; cd08946 234621001367 substrate binding site [chemical binding]; other site 234621001368 active site 234621001369 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 234621001370 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 234621001371 active site 234621001372 Methyltransferase domain; Region: Methyltransf_23; pfam13489 234621001373 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 234621001374 S-adenosylmethionine binding site [chemical binding]; other site 234621001375 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 234621001376 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 234621001377 active site 234621001378 Methyltransferase domain; Region: Methyltransf_24; pfam13578 234621001379 GTPase RsgA; Reviewed; Region: PRK01889 234621001380 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 234621001381 GTPase/Zn-binding domain interface [polypeptide binding]; other site 234621001382 GTP/Mg2+ binding site [chemical binding]; other site 234621001383 G4 box; other site 234621001384 G5 box; other site 234621001385 G1 box; other site 234621001386 Switch I region; other site 234621001387 G2 box; other site 234621001388 G3 box; other site 234621001389 Switch II region; other site 234621001390 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 234621001391 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 234621001392 active site 234621001393 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 234621001394 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 234621001395 Walker A/P-loop; other site 234621001396 ATP binding site [chemical binding]; other site 234621001397 Q-loop/lid; other site 234621001398 ABC transporter signature motif; other site 234621001399 Walker B; other site 234621001400 D-loop; other site 234621001401 H-loop/switch region; other site 234621001402 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 234621001403 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 234621001404 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 234621001405 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 234621001406 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 234621001407 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 234621001408 catalytic residue [active] 234621001409 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 234621001410 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 234621001411 NAD(P) binding site [chemical binding]; other site 234621001412 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 234621001413 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 234621001414 putative active site [active] 234621001415 putative substrate binding site [chemical binding]; other site 234621001416 putative FMN binding site [chemical binding]; other site 234621001417 putative catalytic residues [active] 234621001418 Transcriptional regulators [Transcription]; Region: MarR; COG1846 234621001419 MarR family; Region: MarR_2; cl17246 234621001420 MspA; Region: MspA; pfam09203 234621001421 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 234621001422 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 234621001423 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 234621001424 active site 234621001425 MspA; Region: MspA; pfam09203 234621001426 EBNA-3B; Provisional; Region: PHA03378 234621001427 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 234621001428 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 234621001429 Nitrogen regulatory protein P-II; Region: P-II; cl00412 234621001430 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 234621001431 alpha-gamma subunit interface [polypeptide binding]; other site 234621001432 beta-gamma subunit interface [polypeptide binding]; other site 234621001433 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 234621001434 alpha-beta subunit interface [polypeptide binding]; other site 234621001435 urease subunit alpha; Reviewed; Region: ureC; PRK13309 234621001436 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 234621001437 subunit interactions [polypeptide binding]; other site 234621001438 active site 234621001439 flap region; other site 234621001440 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 234621001441 urease accessory protein UreE; Provisional; Region: ureE; PRK14711 234621001442 dimer interface [polypeptide binding]; other site 234621001443 catalytic residues [active] 234621001444 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 234621001445 UreF; Region: UreF; pfam01730 234621001446 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 234621001447 G1 box; other site 234621001448 GTP/Mg2+ binding site [chemical binding]; other site 234621001449 G2 box; other site 234621001450 Switch I region; other site 234621001451 Switch II region; other site 234621001452 G4 box; other site 234621001453 G5 box; other site 234621001454 UreD urease accessory protein; Region: UreD; cl00530 234621001455 Urea transporter; Region: UT; cl01829 234621001456 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 234621001457 AAA domain; Region: AAA_33; pfam13671 234621001458 ATP-binding site [chemical binding]; other site 234621001459 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 234621001460 gluconate 5-dehydrogenase; Provisional; Region: PRK07523 234621001461 NADP binding site [chemical binding]; other site 234621001462 homodimer interface [polypeptide binding]; other site 234621001463 active site 234621001464 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159 234621001465 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 234621001466 putative ligand binding site [chemical binding]; other site 234621001467 putative NAD binding site [chemical binding]; other site 234621001468 catalytic site [active] 234621001469 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 234621001470 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 234621001471 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 234621001472 putative dimerization interface [polypeptide binding]; other site 234621001473 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 234621001474 putative active site [active] 234621001475 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 234621001476 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 234621001477 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 234621001478 metabolite-proton symporter; Region: 2A0106; TIGR00883 234621001479 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621001480 putative substrate translocation pore; other site 234621001481 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 234621001482 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621001483 NAD(P) binding site [chemical binding]; other site 234621001484 active site 234621001485 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 234621001486 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 234621001487 putative NAD(P) binding site [chemical binding]; other site 234621001488 catalytic Zn binding site [ion binding]; other site 234621001489 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 234621001490 aspartate aminotransferase; Provisional; Region: PRK06107 234621001491 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 234621001492 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234621001493 homodimer interface [polypeptide binding]; other site 234621001494 catalytic residue [active] 234621001495 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 234621001496 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 234621001497 Putative esterase; Region: Esterase; pfam00756 234621001498 Uncharacterized protein family (UPF0160); Region: UPF0160; cl01749 234621001499 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 234621001500 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 234621001501 putative active site [active] 234621001502 putative metal binding site [ion binding]; other site 234621001503 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 234621001504 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 234621001505 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 234621001506 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234621001507 homodimer interface [polypeptide binding]; other site 234621001508 catalytic residue [active] 234621001509 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 234621001510 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 234621001511 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 234621001512 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 234621001513 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 234621001514 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 234621001515 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 234621001516 siderophore binding site; other site 234621001517 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 234621001518 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 234621001519 ABC-ATPase subunit interface; other site 234621001520 dimer interface [polypeptide binding]; other site 234621001521 putative PBP binding regions; other site 234621001522 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 234621001523 ABC-ATPase subunit interface; other site 234621001524 dimer interface [polypeptide binding]; other site 234621001525 putative PBP binding regions; other site 234621001526 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 234621001527 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 234621001528 Walker A/P-loop; other site 234621001529 ATP binding site [chemical binding]; other site 234621001530 Q-loop/lid; other site 234621001531 ABC transporter signature motif; other site 234621001532 Walker B; other site 234621001533 D-loop; other site 234621001534 H-loop/switch region; other site 234621001535 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 234621001536 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 234621001537 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 234621001538 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234621001539 Protein of unknown function (DUF998); Region: DUF998; pfam06197 234621001540 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 234621001541 additional DNA contacts [nucleotide binding]; other site 234621001542 mismatch recognition site; other site 234621001543 active site 234621001544 zinc binding site [ion binding]; other site 234621001545 DNA intercalation site [nucleotide binding]; other site 234621001546 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 234621001547 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 234621001548 cofactor binding site; other site 234621001549 DNA binding site [nucleotide binding] 234621001550 substrate interaction site [chemical binding]; other site 234621001551 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 234621001552 prephenate dehydrogenase; Validated; Region: PRK06545 234621001553 prephenate dehydrogenase; Validated; Region: PRK08507 234621001554 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 234621001555 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 234621001556 nucleoside/Zn binding site; other site 234621001557 dimer interface [polypeptide binding]; other site 234621001558 catalytic motif [active] 234621001559 CsbD-like; Region: CsbD; pfam05532 234621001560 YceI-like domain; Region: YceI; pfam04264 234621001561 Domain of unknown function (DUF202); Region: DUF202; cl09954 234621001562 Domain of unknown function (DUF202); Region: DUF202; pfam02656 234621001563 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 234621001564 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 234621001565 Predicted transcriptional regulator [Transcription]; Region: COG1959 234621001566 Transcriptional regulator; Region: Rrf2; pfam02082 234621001567 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 234621001568 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 234621001569 metal binding site [ion binding]; metal-binding site 234621001570 active site 234621001571 I-site; other site 234621001572 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 234621001573 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621001574 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 234621001575 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 234621001576 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 234621001577 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234621001578 Walker A/P-loop; other site 234621001579 ATP binding site [chemical binding]; other site 234621001580 Q-loop/lid; other site 234621001581 ABC transporter signature motif; other site 234621001582 Walker B; other site 234621001583 D-loop; other site 234621001584 H-loop/switch region; other site 234621001585 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 234621001586 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 234621001587 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 234621001588 Walker A/P-loop; other site 234621001589 ATP binding site [chemical binding]; other site 234621001590 Q-loop/lid; other site 234621001591 ABC transporter signature motif; other site 234621001592 Walker B; other site 234621001593 D-loop; other site 234621001594 H-loop/switch region; other site 234621001595 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 234621001596 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 234621001597 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 234621001598 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 234621001599 RDD family; Region: RDD; pfam06271 234621001600 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 234621001601 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 234621001602 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 234621001603 active site 234621001604 HIGH motif; other site 234621001605 nucleotide binding site [chemical binding]; other site 234621001606 active site 234621001607 KMSKS motif; other site 234621001608 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621001609 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621001610 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 234621001611 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 234621001612 TIGR03086 family protein; Region: TIGR03086 234621001613 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 234621001614 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 234621001615 AsnC family; Region: AsnC_trans_reg; pfam01037 234621001616 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 234621001617 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 234621001618 acetylornithine deacetylase; Provisional; Region: PRK07522 234621001619 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 234621001620 metal binding site [ion binding]; metal-binding site 234621001621 putative dimer interface [polypeptide binding]; other site 234621001622 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621001623 metabolite-proton symporter; Region: 2A0106; TIGR00883 234621001624 putative substrate translocation pore; other site 234621001625 Helix-turn-helix domain; Region: HTH_18; pfam12833 234621001626 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 234621001627 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 234621001628 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234621001629 active site 234621001630 phosphorylation site [posttranslational modification] 234621001631 intermolecular recognition site; other site 234621001632 dimerization interface [polypeptide binding]; other site 234621001633 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 234621001634 DNA binding site [nucleotide binding] 234621001635 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 234621001636 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 234621001637 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 234621001638 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 234621001639 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 234621001640 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 234621001641 catalytic residue [active] 234621001642 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 234621001643 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 234621001644 Transcriptional regulator [Transcription]; Region: LysR; COG0583 234621001645 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 234621001646 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 234621001647 putative dimerization interface [polypeptide binding]; other site 234621001648 Predicted membrane protein [Function unknown]; Region: COG2855 234621001649 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 234621001650 CRISPR/Cas system-associated transcriptional regulator CasRa; Region: CasRa_I-A; cd09655 234621001651 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 234621001652 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 234621001653 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 234621001654 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 234621001655 NADP binding site [chemical binding]; other site 234621001656 dimer interface [polypeptide binding]; other site 234621001657 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 234621001658 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 234621001659 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 234621001660 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621001661 putative substrate translocation pore; other site 234621001662 Major Facilitator Superfamily; Region: MFS_1; pfam07690 234621001663 Serine hydrolase; Region: Ser_hydrolase; pfam06821 234621001664 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 234621001665 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 234621001666 acyl-activating enzyme (AAE) consensus motif; other site 234621001667 putative AMP binding site [chemical binding]; other site 234621001668 putative active site [active] 234621001669 putative CoA binding site [chemical binding]; other site 234621001670 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 234621001671 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 234621001672 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 234621001673 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234621001674 Walker A motif; other site 234621001675 ATP binding site [chemical binding]; other site 234621001676 Walker B motif; other site 234621001677 arginine finger; other site 234621001678 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 234621001679 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 234621001680 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 234621001681 active site 234621001682 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 234621001683 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 234621001684 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 234621001685 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 234621001686 putative NADP binding site [chemical binding]; other site 234621001687 active site 234621001688 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 234621001689 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 234621001690 Thioesterase-like superfamily; Region: 4HBT_2; pfam13279 234621001691 active site 2 [active] 234621001692 active site 1 [active] 234621001693 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 234621001694 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 234621001695 Multicopper oxidase; Region: Cu-oxidase; pfam00394 234621001696 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 234621001697 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 234621001698 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 234621001699 dimer interface [polypeptide binding]; other site 234621001700 active site 234621001701 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 234621001702 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 234621001703 substrate binding site [chemical binding]; other site 234621001704 oxyanion hole (OAH) forming residues; other site 234621001705 trimer interface [polypeptide binding]; other site 234621001706 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 234621001707 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 234621001708 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 234621001709 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 234621001710 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234621001711 S-adenosylmethionine binding site [chemical binding]; other site 234621001712 FAD binding domain; Region: FAD_binding_4; pfam01565 234621001713 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 234621001714 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 234621001715 Proteins of 100 residues with WXG; Region: WXG100; cl02005 234621001716 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 234621001717 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 234621001718 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 234621001719 active site 234621001720 metal binding site [ion binding]; metal-binding site 234621001721 hypothetical protein; Validated; Region: PRK00153 234621001722 recombination protein RecR; Reviewed; Region: recR; PRK00076 234621001723 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 234621001724 RecR protein; Region: RecR; pfam02132 234621001725 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 234621001726 putative active site [active] 234621001727 putative metal-binding site [ion binding]; other site 234621001728 tetramer interface [polypeptide binding]; other site 234621001729 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621001730 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621001731 Major Facilitator Superfamily; Region: MFS_1; pfam07690 234621001732 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621001733 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621001734 putative substrate translocation pore; other site 234621001735 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621001736 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621001737 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 234621001738 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 234621001739 DUF35 OB-fold domain; Region: DUF35; pfam01796 234621001740 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 234621001741 active site 2 [active] 234621001742 active site 1 [active] 234621001743 lipid-transfer protein; Provisional; Region: PRK07855 234621001744 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 234621001745 active site 234621001746 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 234621001747 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 234621001748 inhibitor-cofactor binding pocket; inhibition site 234621001749 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234621001750 catalytic residue [active] 234621001751 short chain dehydrogenase; Provisional; Region: PRK12746 234621001752 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621001753 NAD(P) binding site [chemical binding]; other site 234621001754 active site 234621001755 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 234621001756 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 234621001757 dimer interface [polypeptide binding]; other site 234621001758 active site 234621001759 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621001760 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621001761 active site 234621001762 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621001763 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621001764 active site 234621001765 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621001766 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621001767 active site 234621001768 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621001769 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 234621001770 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621001771 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 234621001772 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 234621001773 catalytic triad [active] 234621001774 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 234621001775 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 234621001776 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 234621001777 EamA-like transporter family; Region: EamA; pfam00892 234621001778 Transcriptional regulator [Transcription]; Region: LysR; COG0583 234621001779 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 234621001780 putative DNA binding site [nucleotide binding]; other site 234621001781 putative Zn2+ binding site [ion binding]; other site 234621001782 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 234621001783 putative dimerization interface [polypeptide binding]; other site 234621001784 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 234621001785 2-isopropylmalate synthase; Validated; Region: PRK03739 234621001786 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 234621001787 active site 234621001788 catalytic residues [active] 234621001789 metal binding site [ion binding]; metal-binding site 234621001790 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 234621001791 aspartate kinase; Reviewed; Region: PRK06635 234621001792 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 234621001793 putative nucleotide binding site [chemical binding]; other site 234621001794 putative catalytic residues [active] 234621001795 putative Mg ion binding site [ion binding]; other site 234621001796 putative aspartate binding site [chemical binding]; other site 234621001797 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 234621001798 putative allosteric regulatory site; other site 234621001799 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 234621001800 putative allosteric regulatory residue; other site 234621001801 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 234621001802 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 234621001803 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621001804 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621001805 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621001806 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 234621001807 active site 234621001808 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 234621001809 Domain of unknown function (DUF222); Region: DUF222; pfam02720 234621001810 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 234621001811 active site 234621001812 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621001813 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621001814 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 234621001815 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 234621001816 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 234621001817 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 234621001818 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 234621001819 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 234621001820 CoA-transferase family III; Region: CoA_transf_3; pfam02515 234621001821 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 234621001822 active site 234621001823 catalytic residues [active] 234621001824 metal binding site [ion binding]; metal-binding site 234621001825 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cl02713 234621001826 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 234621001827 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234621001828 ATP binding site [chemical binding]; other site 234621001829 Mg2+ binding site [ion binding]; other site 234621001830 G-X-G motif; other site 234621001831 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 234621001832 DNA binding residues [nucleotide binding] 234621001833 dimerization interface [polypeptide binding]; other site 234621001834 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 234621001835 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 234621001836 DNA binding residues [nucleotide binding] 234621001837 dimerization interface [polypeptide binding]; other site 234621001838 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621001839 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621001840 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 234621001841 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 234621001842 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 234621001843 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 234621001844 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 234621001845 classical (c) SDRs; Region: SDR_c; cd05233 234621001846 NAD(P) binding site [chemical binding]; other site 234621001847 active site 234621001848 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 234621001849 classical (c) SDRs; Region: SDR_c; cd05233 234621001850 NAD(P) binding site [chemical binding]; other site 234621001851 active site 234621001852 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 234621001853 TM-ABC transporter signature motif; other site 234621001854 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 234621001855 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 234621001856 Walker A/P-loop; other site 234621001857 ATP binding site [chemical binding]; other site 234621001858 Q-loop/lid; other site 234621001859 ABC transporter signature motif; other site 234621001860 Walker B; other site 234621001861 D-loop; other site 234621001862 H-loop/switch region; other site 234621001863 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 234621001864 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 234621001865 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 234621001866 ligand binding site [chemical binding]; other site 234621001867 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 234621001868 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234621001869 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 234621001870 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 234621001871 tetramer interface [polypeptide binding]; other site 234621001872 TPP-binding site [chemical binding]; other site 234621001873 heterodimer interface [polypeptide binding]; other site 234621001874 phosphorylation loop region [posttranslational modification] 234621001875 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 234621001876 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 234621001877 alpha subunit interface [polypeptide binding]; other site 234621001878 TPP binding site [chemical binding]; other site 234621001879 heterodimer interface [polypeptide binding]; other site 234621001880 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 234621001881 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 234621001882 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 234621001883 acyl-activating enzyme (AAE) consensus motif; other site 234621001884 putative AMP binding site [chemical binding]; other site 234621001885 putative active site [active] 234621001886 putative CoA binding site [chemical binding]; other site 234621001887 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 234621001888 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234621001889 non-specific DNA binding site [nucleotide binding]; other site 234621001890 salt bridge; other site 234621001891 sequence-specific DNA binding site [nucleotide binding]; other site 234621001892 Cupin domain; Region: Cupin_2; pfam07883 234621001893 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 234621001894 metal binding site 2 [ion binding]; metal-binding site 234621001895 putative DNA binding helix; other site 234621001896 metal binding site 1 [ion binding]; metal-binding site 234621001897 dimer interface [polypeptide binding]; other site 234621001898 structural Zn2+ binding site [ion binding]; other site 234621001899 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 234621001900 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 234621001901 tetramer interface [polypeptide binding]; other site 234621001902 heme binding pocket [chemical binding]; other site 234621001903 NADPH binding site [chemical binding]; other site 234621001904 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 234621001905 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 234621001906 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 234621001907 motif II; other site 234621001908 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 234621001909 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 234621001910 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 234621001911 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234621001912 dimer interface [polypeptide binding]; other site 234621001913 phosphorylation site [posttranslational modification] 234621001914 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234621001915 ATP binding site [chemical binding]; other site 234621001916 Mg2+ binding site [ion binding]; other site 234621001917 G-X-G motif; other site 234621001918 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 234621001919 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234621001920 active site 234621001921 phosphorylation site [posttranslational modification] 234621001922 intermolecular recognition site; other site 234621001923 dimerization interface [polypeptide binding]; other site 234621001924 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 234621001925 DNA binding site [nucleotide binding] 234621001926 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 234621001927 Cholesterol oxidase, substrate-binding; Region: Chol_subst-bind; pfam09129 234621001928 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 234621001929 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621001930 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621001931 MarR family; Region: MarR_2; pfam12802 234621001932 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 234621001933 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 234621001934 siderophore binding site; other site 234621001935 acyl-CoA synthetase; Validated; Region: PRK07798 234621001936 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621001937 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 234621001938 acyl-activating enzyme (AAE) consensus motif; other site 234621001939 acyl-activating enzyme (AAE) consensus motif; other site 234621001940 putative AMP binding site [chemical binding]; other site 234621001941 putative active site [active] 234621001942 putative CoA binding site [chemical binding]; other site 234621001943 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 234621001944 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 234621001945 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 234621001946 putative active site [active] 234621001947 putative metal binding site [ion binding]; other site 234621001948 Yqey-like protein; Region: YqeY; pfam09424 234621001949 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 234621001950 Transglycosylase; Region: Transgly; pfam00912 234621001951 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 234621001952 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 234621001953 Transcription factor WhiB; Region: Whib; pfam02467 234621001954 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 234621001955 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 234621001956 DTAP/Switch II; other site 234621001957 Switch I; other site 234621001958 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 234621001959 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 234621001960 P loop; other site 234621001961 Nucleotide binding site [chemical binding]; other site 234621001962 DTAP/Switch II; other site 234621001963 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 234621001964 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 234621001965 homotrimer interaction site [polypeptide binding]; other site 234621001966 putative active site [active] 234621001967 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 234621001968 2-hydroxymuconic semialdehyde dehydrogenase; Region: OH_muco_semi_DH; TIGR03216 234621001969 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 234621001970 NAD binding site [chemical binding]; other site 234621001971 catalytic residues [active] 234621001972 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 234621001973 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 234621001974 homotrimer interaction site [polypeptide binding]; other site 234621001975 putative active site [active] 234621001976 3-hydroxyanthranilate 3,4-dioxygenase; Provisional; Region: PRK13264 234621001977 Amidohydrolase; Region: Amidohydro_2; pfam04909 234621001978 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621001979 metabolite-proton symporter; Region: 2A0106; TIGR00883 234621001980 putative substrate translocation pore; other site 234621001981 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 234621001982 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 234621001983 dimerization interface [polypeptide binding]; other site 234621001984 Carboxylesterase family; Region: COesterase; pfam00135 234621001985 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 234621001986 substrate binding pocket [chemical binding]; other site 234621001987 catalytic triad [active] 234621001988 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621001989 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621001990 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 234621001991 SnoaL-like domain; Region: SnoaL_2; pfam12680 234621001992 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 234621001993 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 234621001994 ligand binding site [chemical binding]; other site 234621001995 flexible hinge region; other site 234621001996 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 234621001997 putative switch regulator; other site 234621001998 non-specific DNA interactions [nucleotide binding]; other site 234621001999 DNA binding site [nucleotide binding] 234621002000 sequence specific DNA binding site [nucleotide binding]; other site 234621002001 putative cAMP binding site [chemical binding]; other site 234621002002 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 234621002003 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 234621002004 minor groove reading motif; other site 234621002005 helix-hairpin-helix signature motif; other site 234621002006 substrate binding pocket [chemical binding]; other site 234621002007 active site 234621002008 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 234621002009 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 234621002010 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 234621002011 catalytic residues [active] 234621002012 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 234621002013 putative active site [active] 234621002014 putative CoA binding site [chemical binding]; other site 234621002015 nudix motif; other site 234621002016 metal binding site [ion binding]; metal-binding site 234621002017 Colicin V production protein; Region: Colicin_V; pfam02674 234621002018 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 234621002019 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 234621002020 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 234621002021 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 234621002022 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 234621002023 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 234621002024 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621002025 metabolite-proton symporter; Region: 2A0106; TIGR00883 234621002026 putative substrate translocation pore; other site 234621002027 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 234621002028 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 234621002029 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 234621002030 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234621002031 Walker A motif; other site 234621002032 ATP binding site [chemical binding]; other site 234621002033 Walker B motif; other site 234621002034 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 234621002035 acylamide amidohydrolase; Provisional; Region: amiE; PRK13286 234621002036 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 234621002037 multimer interface [polypeptide binding]; other site 234621002038 active site 234621002039 catalytic triad [active] 234621002040 dimer interface [polypeptide binding]; other site 234621002041 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 234621002042 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 234621002043 Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358 234621002044 putative ligand binding site [chemical binding]; other site 234621002045 MarR family; Region: MarR_2; pfam12802 234621002046 acetyl-CoA synthetase; Provisional; Region: PRK00174 234621002047 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 234621002048 active site 234621002049 CoA binding site [chemical binding]; other site 234621002050 acyl-activating enzyme (AAE) consensus motif; other site 234621002051 AMP binding site [chemical binding]; other site 234621002052 acetate binding site [chemical binding]; other site 234621002053 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 234621002054 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 234621002055 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 234621002056 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234621002057 dimer interface [polypeptide binding]; other site 234621002058 conserved gate region; other site 234621002059 putative PBP binding loops; other site 234621002060 ABC-ATPase subunit interface; other site 234621002061 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 234621002062 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234621002063 dimer interface [polypeptide binding]; other site 234621002064 conserved gate region; other site 234621002065 putative PBP binding loops; other site 234621002066 ABC-ATPase subunit interface; other site 234621002067 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 234621002068 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 234621002069 Walker A/P-loop; other site 234621002070 ATP binding site [chemical binding]; other site 234621002071 Q-loop/lid; other site 234621002072 ABC transporter signature motif; other site 234621002073 Walker B; other site 234621002074 D-loop; other site 234621002075 H-loop/switch region; other site 234621002076 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 234621002077 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 234621002078 Walker A/P-loop; other site 234621002079 ATP binding site [chemical binding]; other site 234621002080 Q-loop/lid; other site 234621002081 ABC transporter signature motif; other site 234621002082 Walker B; other site 234621002083 D-loop; other site 234621002084 H-loop/switch region; other site 234621002085 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 234621002086 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 234621002087 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 234621002088 motif II; other site 234621002089 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 234621002090 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 234621002091 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 234621002092 ATP binding site [chemical binding]; other site 234621002093 Walker A motif; other site 234621002094 hexamer interface [polypeptide binding]; other site 234621002095 Walker B motif; other site 234621002096 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 234621002097 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 234621002098 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 234621002099 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 234621002100 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 234621002101 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 234621002102 ATP binding site [chemical binding]; other site 234621002103 putative Mg++ binding site [ion binding]; other site 234621002104 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 234621002105 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 234621002106 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 234621002107 DNA-binding site [nucleotide binding]; DNA binding site 234621002108 RNA-binding motif; other site 234621002109 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 234621002110 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 234621002111 active site 234621002112 interdomain interaction site; other site 234621002113 putative metal-binding site [ion binding]; other site 234621002114 nucleotide binding site [chemical binding]; other site 234621002115 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 234621002116 domain I; other site 234621002117 phosphate binding site [ion binding]; other site 234621002118 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 234621002119 domain II; other site 234621002120 domain III; other site 234621002121 nucleotide binding site [chemical binding]; other site 234621002122 DNA binding groove [nucleotide binding] 234621002123 catalytic site [active] 234621002124 domain IV; other site 234621002125 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 234621002126 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 234621002127 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 234621002128 DNA polymerase III subunit delta'; Validated; Region: PRK07940 234621002129 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 234621002130 Walker A motif; other site 234621002131 ATP binding site [chemical binding]; other site 234621002132 Walker B motif; other site 234621002133 arginine finger; other site 234621002134 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 234621002135 RDD family; Region: RDD; pfam06271 234621002136 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 234621002137 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 234621002138 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 234621002139 NAD binding site [chemical binding]; other site 234621002140 catalytic residues [active] 234621002141 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 234621002142 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 234621002143 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 234621002144 active site 234621002145 catalytic tetrad [active] 234621002146 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 234621002147 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 234621002148 Walker A/P-loop; other site 234621002149 ATP binding site [chemical binding]; other site 234621002150 Q-loop/lid; other site 234621002151 ABC transporter signature motif; other site 234621002152 Walker B; other site 234621002153 D-loop; other site 234621002154 H-loop/switch region; other site 234621002155 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 234621002156 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 234621002157 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 234621002158 Walker A/P-loop; other site 234621002159 ATP binding site [chemical binding]; other site 234621002160 Q-loop/lid; other site 234621002161 ABC transporter signature motif; other site 234621002162 Walker B; other site 234621002163 D-loop; other site 234621002164 H-loop/switch region; other site 234621002165 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 234621002166 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 234621002167 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234621002168 ABC-ATPase subunit interface; other site 234621002169 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 234621002170 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234621002171 dimer interface [polypeptide binding]; other site 234621002172 conserved gate region; other site 234621002173 ABC-ATPase subunit interface; other site 234621002174 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 234621002175 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 234621002176 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 234621002177 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 234621002178 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 234621002179 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 234621002180 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 234621002181 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 234621002182 transposase/IS protein; Provisional; Region: PRK09183 234621002183 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234621002184 Walker A motif; other site 234621002185 ATP binding site [chemical binding]; other site 234621002186 Walker B motif; other site 234621002187 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 234621002188 Integrase core domain; Region: rve; pfam00665 234621002189 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 234621002190 DNA-binding site [nucleotide binding]; DNA binding site 234621002191 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 234621002192 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 234621002193 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234621002194 homodimer interface [polypeptide binding]; other site 234621002195 catalytic residue [active] 234621002196 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 234621002197 Uncharacterized conserved protein [Function unknown]; Region: COG2128 234621002198 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 234621002199 active site 234621002200 putative catalytic site [active] 234621002201 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 234621002202 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621002203 NAD(P) binding site [chemical binding]; other site 234621002204 active site 234621002205 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 234621002206 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 234621002207 metal binding site [ion binding]; metal-binding site 234621002208 active site 234621002209 I-site; other site 234621002210 Transcriptional regulators [Transcription]; Region: FadR; COG2186 234621002211 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 234621002212 DNA-binding site [nucleotide binding]; DNA binding site 234621002213 FCD domain; Region: FCD; pfam07729 234621002214 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621002215 Major Facilitator Superfamily; Region: MFS_1; pfam07690 234621002216 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 234621002217 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 234621002218 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234621002219 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 234621002220 Zn binding site [ion binding]; other site 234621002221 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621002222 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 234621002223 acyl-activating enzyme (AAE) consensus motif; other site 234621002224 AMP binding site [chemical binding]; other site 234621002225 active site 234621002226 CoA binding site [chemical binding]; other site 234621002227 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 234621002228 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 234621002229 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 234621002230 putative trimer interface [polypeptide binding]; other site 234621002231 putative CoA binding site [chemical binding]; other site 234621002232 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 234621002233 putative trimer interface [polypeptide binding]; other site 234621002234 putative CoA binding site [chemical binding]; other site 234621002235 BCCT family transporter; Region: BCCT; pfam02028 234621002236 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cl00364 234621002237 L11 interface [polypeptide binding]; other site 234621002238 putative EF-Tu interaction site [polypeptide binding]; other site 234621002239 putative EF-G interaction site [polypeptide binding]; other site 234621002240 short chain dehydrogenase; Provisional; Region: PRK07041 234621002241 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621002242 NAD(P) binding site [chemical binding]; other site 234621002243 active site 234621002244 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 234621002245 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 234621002246 Na binding site [ion binding]; other site 234621002247 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 234621002248 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 234621002249 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 234621002250 Protein of unknown function (DUF917); Region: DUF917; pfam06032 234621002251 Protein of unknown function (DUF917); Region: DUF917; pfam06032 234621002252 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 234621002253 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 234621002254 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 234621002255 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 234621002256 catalytic residue [active] 234621002257 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 234621002258 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 234621002259 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 234621002260 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234621002261 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 234621002262 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 234621002263 CGNR zinc finger; Region: zf-CGNR; pfam11706 234621002264 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 234621002265 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 234621002266 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621002267 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621002268 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621002269 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621002270 RNase domain (also known as the kinase extension nuclease domain) of Ire1 and RNase L; Region: RNase_Ire1_like; cl15368 234621002271 EamA-like transporter family; Region: EamA; pfam00892 234621002272 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 234621002273 H+ Antiporter protein; Region: 2A0121; TIGR00900 234621002274 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621002275 putative substrate translocation pore; other site 234621002276 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 234621002277 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 234621002278 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621002279 Major Facilitator Superfamily; Region: MFS_1; pfam07690 234621002280 putative substrate translocation pore; other site 234621002281 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621002282 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 234621002283 putative homodimer interface [polypeptide binding]; other site 234621002284 putative homotetramer interface [polypeptide binding]; other site 234621002285 putative allosteric switch controlling residues; other site 234621002286 putative metal binding site [ion binding]; other site 234621002287 putative homodimer-homodimer interface [polypeptide binding]; other site 234621002288 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 234621002289 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 234621002290 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 234621002291 Methyltransferase domain; Region: Methyltransf_23; pfam13489 234621002292 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234621002293 S-adenosylmethionine binding site [chemical binding]; other site 234621002294 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 234621002295 agmatinase; Region: agmatinase; TIGR01230 234621002296 oligomer interface [polypeptide binding]; other site 234621002297 putative active site [active] 234621002298 Mn binding site [ion binding]; other site 234621002299 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 234621002300 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234621002301 non-specific DNA binding site [nucleotide binding]; other site 234621002302 salt bridge; other site 234621002303 sequence-specific DNA binding site [nucleotide binding]; other site 234621002304 Predicted amidohydrolase [General function prediction only]; Region: COG0388 234621002305 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 234621002306 putative active site [active] 234621002307 catalytic triad [active] 234621002308 putative dimer interface [polypeptide binding]; other site 234621002309 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 234621002310 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 234621002311 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 234621002312 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 234621002313 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 234621002314 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 234621002315 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 234621002316 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 234621002317 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 234621002318 inhibitor-cofactor binding pocket; inhibition site 234621002319 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234621002320 catalytic residue [active] 234621002321 succinic semialdehyde dehydrogenase; Region: PLN02278 234621002322 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 234621002323 tetramerization interface [polypeptide binding]; other site 234621002324 NAD(P) binding site [chemical binding]; other site 234621002325 catalytic residues [active] 234621002326 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 234621002327 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 234621002328 putative deacylase active site [active] 234621002329 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 234621002330 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 234621002331 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621002332 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621002333 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 234621002334 magnesium-transporting ATPase; Provisional; Region: PRK15122 234621002335 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 234621002336 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 234621002337 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 234621002338 Soluble P-type ATPase [General function prediction only]; Region: COG4087 234621002339 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 234621002340 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 234621002341 MgtC family; Region: MgtC; pfam02308 234621002342 Secretory lipase; Region: LIP; pfam03583 234621002343 putative acetyltransferase; Provisional; Region: PRK03624 234621002344 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 234621002345 Coenzyme A binding pocket [chemical binding]; other site 234621002346 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 234621002347 Coenzyme A binding pocket [chemical binding]; other site 234621002348 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 234621002349 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 234621002350 putative metal binding site [ion binding]; other site 234621002351 hypothetical protein; Provisional; Region: PRK14013 234621002352 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 234621002353 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 234621002354 putative metal binding site [ion binding]; other site 234621002355 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 234621002356 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 234621002357 active site 234621002358 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 234621002359 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 234621002360 mannosyl-3-phosphoglycerate phosphatase family; Region: HAD-SF-IIB-MPGP; TIGR01486 234621002361 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 234621002362 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 234621002363 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 234621002364 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 234621002365 putative metal binding site [ion binding]; other site 234621002366 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 234621002367 active site 234621002368 catalytic triad [active] 234621002369 oxyanion hole [active] 234621002370 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 234621002371 putative metal binding site [ion binding]; other site 234621002372 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 234621002373 tellurite resistance protein terB; Region: terB; cd07176 234621002374 putative metal binding site [ion binding]; other site 234621002375 putative OHCU decarboxylase; Provisional; Region: PRK13798 234621002376 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 234621002377 RNA binding site [nucleotide binding]; other site 234621002378 Secretory lipase; Region: LIP; pfam03583 234621002379 AAA domain; Region: AAA_17; pfam13207 234621002380 AAA domain; Region: AAA_18; pfam13238 234621002381 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 234621002382 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 234621002383 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 234621002384 NodB motif; other site 234621002385 active site 234621002386 catalytic site [active] 234621002387 metal binding site [ion binding]; metal-binding site 234621002388 Transcriptional regulator [Transcription]; Region: LytR; COG1316 234621002389 enoyl-CoA hydratase; Provisional; Region: PRK06142 234621002390 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 234621002391 substrate binding site [chemical binding]; other site 234621002392 oxyanion hole (OAH) forming residues; other site 234621002393 trimer interface [polypeptide binding]; other site 234621002394 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 234621002395 dimer interface [polypeptide binding]; other site 234621002396 substrate binding site [chemical binding]; other site 234621002397 metal binding sites [ion binding]; metal-binding site 234621002398 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 234621002399 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 234621002400 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 234621002401 putative hydrolase; Region: TIGR03624 234621002402 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 234621002403 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 234621002404 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 234621002405 active site 234621002406 AAA domain; Region: AAA_21; pfam13304 234621002407 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234621002408 Walker B; other site 234621002409 D-loop; other site 234621002410 H-loop/switch region; other site 234621002411 HNH endonuclease; Region: HNH; pfam01844 234621002412 FtsH Extracellular; Region: FtsH_ext; pfam06480 234621002413 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 234621002414 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234621002415 Walker A motif; other site 234621002416 ATP binding site [chemical binding]; other site 234621002417 Walker B motif; other site 234621002418 arginine finger; other site 234621002419 Peptidase family M41; Region: Peptidase_M41; pfam01434 234621002420 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 234621002421 homodecamer interface [polypeptide binding]; other site 234621002422 GTP cyclohydrolase I; Provisional; Region: PLN03044 234621002423 active site 234621002424 putative catalytic site residues [active] 234621002425 zinc binding site [ion binding]; other site 234621002426 GTP-CH-I/GFRP interaction surface; other site 234621002427 dihydropteroate synthase; Region: DHPS; TIGR01496 234621002428 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 234621002429 substrate binding pocket [chemical binding]; other site 234621002430 dimer interface [polypeptide binding]; other site 234621002431 inhibitor binding site; inhibition site 234621002432 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 234621002433 homooctamer interface [polypeptide binding]; other site 234621002434 active site 234621002435 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 234621002436 catalytic center binding site [active] 234621002437 ATP binding site [chemical binding]; other site 234621002438 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 234621002439 Uncharacterized conserved protein [Function unknown]; Region: COG5495 234621002440 Rossmann-like domain; Region: Rossmann-like; pfam10727 234621002441 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 234621002442 pantoate--beta-alanine ligase; Region: panC; TIGR00018 234621002443 Pantoate-beta-alanine ligase; Region: PanC; cd00560 234621002444 active site 234621002445 ATP-binding site [chemical binding]; other site 234621002446 pantoate-binding site; other site 234621002447 HXXH motif; other site 234621002448 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 234621002449 tetramerization interface [polypeptide binding]; other site 234621002450 active site 234621002451 pantothenate kinase; Reviewed; Region: PRK13318 234621002452 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 234621002453 Rhodanese Homology Domain; Region: RHOD; smart00450 234621002454 active site residue [active] 234621002455 Cupin; Region: Cupin_6; pfam12852 234621002456 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 234621002457 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 234621002458 NADH(P)-binding; Region: NAD_binding_10; pfam13460 234621002459 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621002460 NAD(P) binding site [chemical binding]; other site 234621002461 active site 234621002462 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 234621002463 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 234621002464 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 234621002465 dimer interface [polypeptide binding]; other site 234621002466 putative anticodon binding site; other site 234621002467 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 234621002468 motif 1; other site 234621002469 dimer interface [polypeptide binding]; other site 234621002470 active site 234621002471 motif 2; other site 234621002472 motif 3; other site 234621002473 Lsr2; Region: Lsr2; pfam11774 234621002474 Lipase (class 2); Region: Lipase_2; pfam01674 234621002475 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 234621002476 Lipase (class 2); Region: Lipase_2; pfam01674 234621002477 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 234621002478 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 234621002479 Clp amino terminal domain; Region: Clp_N; pfam02861 234621002480 Clp amino terminal domain; Region: Clp_N; pfam02861 234621002481 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234621002482 Walker A motif; other site 234621002483 ATP binding site [chemical binding]; other site 234621002484 Walker B motif; other site 234621002485 arginine finger; other site 234621002486 UvrB/uvrC motif; Region: UVR; pfam02151 234621002487 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234621002488 Walker A motif; other site 234621002489 ATP binding site [chemical binding]; other site 234621002490 Walker B motif; other site 234621002491 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 234621002492 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 234621002493 nucleoside/Zn binding site; other site 234621002494 dimer interface [polypeptide binding]; other site 234621002495 catalytic motif [active] 234621002496 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 234621002497 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621002498 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 234621002499 acyl-activating enzyme (AAE) consensus motif; other site 234621002500 acyl-activating enzyme (AAE) consensus motif; other site 234621002501 putative AMP binding site [chemical binding]; other site 234621002502 putative active site [active] 234621002503 putative CoA binding site [chemical binding]; other site 234621002504 enoyl-CoA hydratase; Provisional; Region: PRK06688 234621002505 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 234621002506 substrate binding site [chemical binding]; other site 234621002507 oxyanion hole (OAH) forming residues; other site 234621002508 trimer interface [polypeptide binding]; other site 234621002509 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 234621002510 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 234621002511 FMN binding site [chemical binding]; other site 234621002512 substrate binding site [chemical binding]; other site 234621002513 putative catalytic residue [active] 234621002514 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621002515 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621002516 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621002517 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621002518 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 234621002519 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 234621002520 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 234621002521 Histidine kinase; Region: HisKA_3; pfam07730 234621002522 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 234621002523 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234621002524 active site 234621002525 phosphorylation site [posttranslational modification] 234621002526 intermolecular recognition site; other site 234621002527 dimerization interface [polypeptide binding]; other site 234621002528 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 234621002529 DNA binding residues [nucleotide binding] 234621002530 dimerization interface [polypeptide binding]; other site 234621002531 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 234621002532 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 234621002533 catalytic residues [active] 234621002534 GAF domain; Region: GAF; pfam01590 234621002535 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 234621002536 acetoin reductases; Region: 23BDH; TIGR02415 234621002537 NAD binding site [chemical binding]; other site 234621002538 homotetramer interface [polypeptide binding]; other site 234621002539 homodimer interface [polypeptide binding]; other site 234621002540 active site 234621002541 substrate binding site [chemical binding]; other site 234621002542 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 234621002543 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 234621002544 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 234621002545 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 234621002546 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 234621002547 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 234621002548 catalytic site [active] 234621002549 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 234621002550 HIT family signature motif; other site 234621002551 catalytic residue [active] 234621002552 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 234621002553 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 234621002554 DNA binding residues [nucleotide binding] 234621002555 dimerization interface [polypeptide binding]; other site 234621002556 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 234621002557 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 234621002558 minor groove reading motif; other site 234621002559 helix-hairpin-helix signature motif; other site 234621002560 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 234621002561 mce related protein; Region: MCE; pfam02470 234621002562 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 234621002563 mce related protein; Region: MCE; pfam02470 234621002564 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 234621002565 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 234621002566 mce related protein; Region: MCE; pfam02470 234621002567 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 234621002568 mce related protein; Region: MCE; pfam02470 234621002569 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 234621002570 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 234621002571 mce related protein; Region: MCE; pfam02470 234621002572 mce related protein; Region: MCE; pfam02470 234621002573 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 234621002574 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 234621002575 Permease; Region: Permease; pfam02405 234621002576 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 234621002577 Permease; Region: Permease; pfam02405 234621002578 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 234621002579 active site clefts [active] 234621002580 zinc binding site [ion binding]; other site 234621002581 dimer interface [polypeptide binding]; other site 234621002582 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 234621002583 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 234621002584 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 234621002585 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 234621002586 CoenzymeA binding site [chemical binding]; other site 234621002587 subunit interaction site [polypeptide binding]; other site 234621002588 PHB binding site; other site 234621002589 DNA repair protein RadA; Provisional; Region: PRK11823 234621002590 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 234621002591 Walker A motif; other site 234621002592 ATP binding site [chemical binding]; other site 234621002593 Walker B motif; other site 234621002594 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 234621002595 Protein of unknown function (DUF461); Region: DUF461; cl01071 234621002596 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 234621002597 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 234621002598 substrate binding site; other site 234621002599 dimer interface; other site 234621002600 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 234621002601 homotrimer interaction site [polypeptide binding]; other site 234621002602 zinc binding site [ion binding]; other site 234621002603 CDP-binding sites; other site 234621002604 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 234621002605 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 234621002606 active site 234621002607 HIGH motif; other site 234621002608 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 234621002609 KMSKS motif; other site 234621002610 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 234621002611 tRNA binding surface [nucleotide binding]; other site 234621002612 anticodon binding site; other site 234621002613 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 234621002614 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 234621002615 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 234621002616 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 234621002617 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 234621002618 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234621002619 Walker A/P-loop; other site 234621002620 ATP binding site [chemical binding]; other site 234621002621 Q-loop/lid; other site 234621002622 ABC transporter signature motif; other site 234621002623 Walker B; other site 234621002624 D-loop; other site 234621002625 H-loop/switch region; other site 234621002626 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 234621002627 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 234621002628 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234621002629 Q-loop/lid; other site 234621002630 ABC transporter signature motif; other site 234621002631 Walker B; other site 234621002632 D-loop; other site 234621002633 H-loop/switch region; other site 234621002634 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 234621002635 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 234621002636 siderophore binding site; other site 234621002637 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 234621002638 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 234621002639 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 234621002640 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 234621002641 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 234621002642 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 234621002643 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 234621002644 putative active site [active] 234621002645 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 234621002646 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 234621002647 dimer interface [polypeptide binding]; other site 234621002648 putative PBP binding regions; other site 234621002649 ABC-ATPase subunit interface; other site 234621002650 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 234621002651 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234621002652 Walker A/P-loop; other site 234621002653 ATP binding site [chemical binding]; other site 234621002654 Q-loop/lid; other site 234621002655 ABC transporter signature motif; other site 234621002656 Walker B; other site 234621002657 D-loop; other site 234621002658 H-loop/switch region; other site 234621002659 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 234621002660 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 234621002661 intersubunit interface [polypeptide binding]; other site 234621002662 Transcriptional regulators [Transcription]; Region: PurR; COG1609 234621002663 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 234621002664 DNA binding site [nucleotide binding] 234621002665 domain linker motif; other site 234621002666 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 234621002667 putative dimerization interface [polypeptide binding]; other site 234621002668 putative ligand binding site [chemical binding]; other site 234621002669 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 234621002670 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 234621002671 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 234621002672 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 234621002673 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621002674 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621002675 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621002676 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 234621002677 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621002678 active site 234621002679 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621002680 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621002681 active site 234621002682 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621002683 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621002684 active site 234621002685 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621002686 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621002687 active site 234621002688 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 234621002689 active site 234621002690 catalytic site [active] 234621002691 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 234621002692 DUF35 OB-fold domain; Region: DUF35; pfam01796 234621002693 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 234621002694 putative active site [active] 234621002695 putative catalytic site [active] 234621002696 lipid-transfer protein; Provisional; Region: PRK07855 234621002697 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 234621002698 active site 234621002699 Domain of unknown function (DUF222); Region: DUF222; pfam02720 234621002700 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 234621002701 active site 234621002702 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 234621002703 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 234621002704 Coenzyme A binding pocket [chemical binding]; other site 234621002705 Helix-turn-helix domain; Region: HTH_18; pfam12833 234621002706 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 234621002707 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234621002708 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 234621002709 dimer interface [polypeptide binding]; other site 234621002710 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 234621002711 Beta-lactamase; Region: Beta-lactamase; pfam00144 234621002712 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 234621002713 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621002714 NAD(P) binding site [chemical binding]; other site 234621002715 active site 234621002716 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 234621002717 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621002718 Glycoside hydrolase family 71; Region: GH71; cd11577 234621002719 putative ligand binding site [chemical binding]; other site 234621002720 putative catalytic site [active] 234621002721 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234621002722 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 234621002723 Walker A/P-loop; other site 234621002724 ATP binding site [chemical binding]; other site 234621002725 Q-loop/lid; other site 234621002726 ABC transporter signature motif; other site 234621002727 Walker B; other site 234621002728 D-loop; other site 234621002729 H-loop/switch region; other site 234621002730 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 234621002731 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 234621002732 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621002733 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621002734 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 234621002735 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234621002736 S-adenosylmethionine binding site [chemical binding]; other site 234621002737 Secretory lipase; Region: LIP; pfam03583 234621002738 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 234621002739 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621002740 Predicted ATPase [General function prediction only]; Region: COG1485 234621002741 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 234621002742 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 234621002743 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 234621002744 Walker A/P-loop; other site 234621002745 ATP binding site [chemical binding]; other site 234621002746 Q-loop/lid; other site 234621002747 ABC transporter signature motif; other site 234621002748 Walker B; other site 234621002749 D-loop; other site 234621002750 H-loop/switch region; other site 234621002751 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 234621002752 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 234621002753 PE-PPE domain; Region: PE-PPE; pfam08237 234621002754 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 234621002755 Beta-lactamase; Region: Beta-lactamase; pfam00144 234621002756 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 234621002757 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 234621002758 DNA binding residues [nucleotide binding] 234621002759 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 234621002760 FAD binding domain; Region: FAD_binding_4; pfam01565 234621002761 Cholesterol oxidase, substrate-binding; Region: Chol_subst-bind; pfam09129 234621002762 enoyl-CoA hydratase; Region: PLN02864 234621002763 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 234621002764 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 234621002765 dimer interaction site [polypeptide binding]; other site 234621002766 substrate-binding tunnel; other site 234621002767 active site 234621002768 catalytic site [active] 234621002769 substrate binding site [chemical binding]; other site 234621002770 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 234621002771 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 234621002772 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844 234621002773 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 234621002774 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 234621002775 acetaldehyde dehydrogenase; Validated; Region: PRK08300 234621002776 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 234621002777 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 234621002778 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 234621002779 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 234621002780 active site 234621002781 catalytic residues [active] 234621002782 metal binding site [ion binding]; metal-binding site 234621002783 DmpG-like communication domain; Region: DmpG_comm; pfam07836 234621002784 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 234621002785 classical (c) SDRs; Region: SDR_c; cd05233 234621002786 NAD(P) binding site [chemical binding]; other site 234621002787 active site 234621002788 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 234621002789 dimer interface [polypeptide binding]; other site 234621002790 substrate binding site [chemical binding]; other site 234621002791 metal binding site [ion binding]; metal-binding site 234621002792 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 234621002793 hypothetical protein; Provisional; Region: PRK06184 234621002794 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 234621002795 nucleotide binding site/active site [active] 234621002796 HIT family signature motif; other site 234621002797 catalytic residue [active] 234621002798 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 234621002799 Fatty acid desaturase; Region: FA_desaturase; pfam00487 234621002800 Di-iron ligands [ion binding]; other site 234621002801 Rubredoxin; Region: Rubredoxin; pfam00301 234621002802 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 234621002803 iron binding site [ion binding]; other site 234621002804 Rubredoxin [Energy production and conversion]; Region: COG1773 234621002805 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 234621002806 iron binding site [ion binding]; other site 234621002807 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 234621002808 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621002809 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621002810 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 234621002811 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 234621002812 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 234621002813 hydrophobic ligand binding site; other site 234621002814 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 234621002815 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 234621002816 Flavin binding site [chemical binding]; other site 234621002817 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 234621002818 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 234621002819 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 234621002820 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 234621002821 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 234621002822 active site 234621002823 Fe binding site [ion binding]; other site 234621002824 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 234621002825 Domain of unknown function (DUF4393); Region: DUF4393; pfam14337 234621002826 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 234621002827 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 234621002828 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 234621002829 active site 234621002830 dimer interface [polypeptide binding]; other site 234621002831 motif 1; other site 234621002832 motif 2; other site 234621002833 motif 3; other site 234621002834 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 234621002835 anticodon binding site; other site 234621002836 MarR family; Region: MarR_2; cl17246 234621002837 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 234621002838 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 234621002839 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621002840 putative substrate translocation pore; other site 234621002841 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734 234621002842 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 234621002843 short chain dehydrogenase; Provisional; Region: PRK05875 234621002844 classical (c) SDRs; Region: SDR_c; cd05233 234621002845 NAD(P) binding site [chemical binding]; other site 234621002846 active site 234621002847 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 234621002848 Cytochrome P450; Region: p450; cl12078 234621002849 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 234621002850 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 234621002851 NAD(P) binding site [chemical binding]; other site 234621002852 catalytic residues [active] 234621002853 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 234621002854 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621002855 NAD(P) binding site [chemical binding]; other site 234621002856 active site 234621002857 PQQ-like domain; Region: PQQ_2; pfam13360 234621002858 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621002859 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 234621002860 Cytochrome P450; Region: p450; cl12078 234621002861 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621002862 acyl-CoA synthetase; Validated; Region: PRK07867 234621002863 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621002864 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621002865 acyl-activating enzyme (AAE) consensus motif; other site 234621002866 acyl-activating enzyme (AAE) consensus motif; other site 234621002867 AMP binding site [chemical binding]; other site 234621002868 active site 234621002869 CoA binding site [chemical binding]; other site 234621002870 Cupin domain; Region: Cupin_2; cl17218 234621002871 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234621002872 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 234621002873 sequence-specific DNA binding site [nucleotide binding]; other site 234621002874 salt bridge; other site 234621002875 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 234621002876 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 234621002877 active site 234621002878 catalytic tetrad [active] 234621002879 ApbE family; Region: ApbE; pfam02424 234621002880 acetyl-CoA acetyltransferase; Provisional; Region: PRK06504 234621002881 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 234621002882 dimer interface [polypeptide binding]; other site 234621002883 active site 234621002884 enoyl-CoA hydratase; Provisional; Region: PRK08252 234621002885 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 234621002886 substrate binding site [chemical binding]; other site 234621002887 oxyanion hole (OAH) forming residues; other site 234621002888 trimer interface [polypeptide binding]; other site 234621002889 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621002890 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621002891 active site 234621002892 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 234621002893 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 234621002894 NAD(P) binding site [chemical binding]; other site 234621002895 catalytic residues [active] 234621002896 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 234621002897 Cytochrome P450; Region: p450; cl12078 234621002898 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 234621002899 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 234621002900 NAD binding site [chemical binding]; other site 234621002901 catalytic residues [active] 234621002902 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621002903 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621002904 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 234621002905 CoA-transferase family III; Region: CoA_transf_3; pfam02515 234621002906 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 234621002907 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 234621002908 catalytic Zn binding site [ion binding]; other site 234621002909 NAD binding site [chemical binding]; other site 234621002910 structural Zn binding site [ion binding]; other site 234621002911 DUF35 OB-fold domain; Region: DUF35; pfam01796 234621002912 thiolase; Provisional; Region: PRK06158 234621002913 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 234621002914 active site 234621002915 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 234621002916 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 234621002917 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 234621002918 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 234621002919 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 234621002920 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 234621002921 enoyl-CoA hydratase; Provisional; Region: PRK05864 234621002922 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 234621002923 substrate binding site [chemical binding]; other site 234621002924 oxyanion hole (OAH) forming residues; other site 234621002925 trimer interface [polypeptide binding]; other site 234621002926 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 234621002927 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621002928 NAD(P) binding site [chemical binding]; other site 234621002929 active site 234621002930 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621002931 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621002932 tetracycline repressor protein TetR; Provisional; Region: PRK13756 234621002933 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621002934 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 234621002935 pyruvate phosphate dikinase; Provisional; Region: PRK05878 234621002936 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 234621002937 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 234621002938 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 234621002939 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 234621002940 Cytochrome P450; Region: p450; cl12078 234621002941 Ferredoxin [Energy production and conversion]; Region: COG1146 234621002942 4Fe-4S binding domain; Region: Fer4; pfam00037 234621002943 ferredoxin-NADP+ reductase; Region: PLN02852 234621002944 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 234621002945 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 234621002946 acyl-activating enzyme (AAE) consensus motif; other site 234621002947 putative AMP binding site [chemical binding]; other site 234621002948 putative active site [active] 234621002949 putative CoA binding site [chemical binding]; other site 234621002950 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 234621002951 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 234621002952 molybdopterin cofactor binding site; other site 234621002953 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 234621002954 Ferredoxin [Energy production and conversion]; Region: COG1146 234621002955 4Fe-4S binding domain; Region: Fer4; pfam00037 234621002956 ferredoxin-NADP+ reductase; Region: PLN02852 234621002957 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 234621002958 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 234621002959 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 234621002960 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 234621002961 FeS/SAM binding site; other site 234621002962 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 234621002963 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234621002964 Catalytic domain of Protein Kinases; Region: PKc; cd00180 234621002965 active site 234621002966 ATP binding site [chemical binding]; other site 234621002967 substrate binding site [chemical binding]; other site 234621002968 activation loop (A-loop); other site 234621002969 Predicted ATPase [General function prediction only]; Region: COG3903 234621002970 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234621002971 TPR motif; other site 234621002972 binding surface 234621002973 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234621002974 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 234621002975 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 234621002976 DNA binding residues [nucleotide binding] 234621002977 dimerization interface [polypeptide binding]; other site 234621002978 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621002979 active site 234621002980 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 234621002981 NADH(P)-binding; Region: NAD_binding_10; pfam13460 234621002982 NAD(P) binding site [chemical binding]; other site 234621002983 putative active site [active] 234621002984 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 234621002985 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 234621002986 active site 234621002987 catalytic tetrad [active] 234621002988 Protein of unknown function (DUF998); Region: DUF998; pfam06197 234621002989 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 234621002990 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 234621002991 membrane-bound complex binding site; other site 234621002992 hinge residues; other site 234621002993 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 234621002994 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 234621002995 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 234621002996 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 234621002997 Walker A/P-loop; other site 234621002998 ATP binding site [chemical binding]; other site 234621002999 Q-loop/lid; other site 234621003000 ABC transporter signature motif; other site 234621003001 Walker B; other site 234621003002 D-loop; other site 234621003003 H-loop/switch region; other site 234621003004 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 234621003005 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234621003006 dimer interface [polypeptide binding]; other site 234621003007 ABC-ATPase subunit interface; other site 234621003008 putative PBP binding loops; other site 234621003009 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 234621003010 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 234621003011 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 234621003012 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621003013 metabolite-proton symporter; Region: 2A0106; TIGR00883 234621003014 putative substrate translocation pore; other site 234621003015 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 234621003016 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 234621003017 Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231 234621003018 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 234621003019 catalytic Zn binding site [ion binding]; other site 234621003020 structural Zn binding site [ion binding]; other site 234621003021 tetramer interface [polypeptide binding]; other site 234621003022 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 234621003023 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 234621003024 NAD binding site [chemical binding]; other site 234621003025 catalytic residues [active] 234621003026 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621003027 Major Facilitator Superfamily; Region: MFS_1; pfam07690 234621003028 putative substrate translocation pore; other site 234621003029 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621003030 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621003031 putative substrate translocation pore; other site 234621003032 Major Facilitator Superfamily; Region: MFS_1; pfam07690 234621003033 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 234621003034 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 234621003035 NAD binding site [chemical binding]; other site 234621003036 catalytic residues [active] 234621003037 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 234621003038 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 234621003039 putative NAD(P) binding site [chemical binding]; other site 234621003040 putative substrate binding site [chemical binding]; other site 234621003041 catalytic Zn binding site [ion binding]; other site 234621003042 structural Zn binding site [ion binding]; other site 234621003043 dimer interface [polypeptide binding]; other site 234621003044 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 234621003045 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 234621003046 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 234621003047 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621003048 metabolite-proton symporter; Region: 2A0106; TIGR00883 234621003049 putative substrate translocation pore; other site 234621003050 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 234621003051 catalytic core [active] 234621003052 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 234621003053 Transcriptional regulator [Transcription]; Region: IclR; COG1414 234621003054 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 234621003055 Bacterial transcriptional regulator; Region: IclR; pfam01614 234621003056 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 234621003057 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 234621003058 substrate binding site [chemical binding]; other site 234621003059 oxyanion hole (OAH) forming residues; other site 234621003060 trimer interface [polypeptide binding]; other site 234621003061 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 234621003062 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621003063 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 234621003064 acyl-activating enzyme (AAE) consensus motif; other site 234621003065 putative AMP binding site [chemical binding]; other site 234621003066 putative active site [active] 234621003067 putative CoA binding site [chemical binding]; other site 234621003068 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 234621003069 active site 234621003070 catalytic site [active] 234621003071 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 234621003072 active site 2 [active] 234621003073 active site 1 [active] 234621003074 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 234621003075 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 234621003076 NAD(P) binding site [chemical binding]; other site 234621003077 catalytic residues [active] 234621003078 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 234621003079 CoA-transferase family III; Region: CoA_transf_3; pfam02515 234621003080 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 234621003081 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 234621003082 putative NAD(P) binding site [chemical binding]; other site 234621003083 catalytic Zn binding site [ion binding]; other site 234621003084 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 234621003085 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 234621003086 active site 234621003087 NAD binding site [chemical binding]; other site 234621003088 metal binding site [ion binding]; metal-binding site 234621003089 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 234621003090 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621003091 NAD(P) binding site [chemical binding]; other site 234621003092 active site 234621003093 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 234621003094 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 234621003095 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 234621003096 NMT1/THI5 like; Region: NMT1; pfam09084 234621003097 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 234621003098 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 234621003099 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234621003100 dimer interface [polypeptide binding]; other site 234621003101 conserved gate region; other site 234621003102 putative PBP binding loops; other site 234621003103 ABC-ATPase subunit interface; other site 234621003104 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 234621003105 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 234621003106 Walker A/P-loop; other site 234621003107 ATP binding site [chemical binding]; other site 234621003108 Q-loop/lid; other site 234621003109 ABC transporter signature motif; other site 234621003110 Walker B; other site 234621003111 D-loop; other site 234621003112 H-loop/switch region; other site 234621003113 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 234621003114 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 234621003115 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 234621003116 Part of AAA domain; Region: AAA_19; pfam13245 234621003117 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 234621003118 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 234621003119 AAA domain; Region: AAA_30; pfam13604 234621003120 Family description; Region: UvrD_C_2; pfam13538 234621003121 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 234621003122 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621003123 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621003124 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234621003125 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 234621003126 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 234621003127 active site 234621003128 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 234621003129 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 234621003130 metabolite-proton symporter; Region: 2A0106; TIGR00883 234621003131 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621003132 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 234621003133 tryptophan synthase subunit beta; Reviewed; Region: PRK12391 234621003134 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 234621003135 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 234621003136 catalytic residue [active] 234621003137 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 234621003138 CoenzymeA binding site [chemical binding]; other site 234621003139 subunit interaction site [polypeptide binding]; other site 234621003140 PHB binding site; other site 234621003141 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621003142 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621003143 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 234621003144 putative hydrophobic ligand binding site [chemical binding]; other site 234621003145 protein interface [polypeptide binding]; other site 234621003146 gate; other site 234621003147 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 234621003148 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 234621003149 putative active site [active] 234621003150 putative FMN binding site [chemical binding]; other site 234621003151 putative substrate binding site [chemical binding]; other site 234621003152 putative catalytic residue [active] 234621003153 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 234621003154 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 234621003155 active site 234621003156 catalytic tetrad [active] 234621003157 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 234621003158 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 234621003159 hexamer interface [polypeptide binding]; other site 234621003160 ligand binding site [chemical binding]; other site 234621003161 putative active site [active] 234621003162 NAD(P) binding site [chemical binding]; other site 234621003163 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 234621003164 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 234621003165 AsnC family; Region: AsnC_trans_reg; pfam01037 234621003166 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 234621003167 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 234621003168 active site 234621003169 dimer interface [polypeptide binding]; other site 234621003170 metal binding site [ion binding]; metal-binding site 234621003171 Pirin-related protein [General function prediction only]; Region: COG1741 234621003172 Pirin; Region: Pirin; pfam02678 234621003173 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 234621003174 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234621003175 Zn binding site [ion binding]; other site 234621003176 MarR family; Region: MarR_2; pfam12802 234621003177 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 234621003178 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 234621003179 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 234621003180 active site 234621003181 motif I; other site 234621003182 motif II; other site 234621003183 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 234621003184 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 234621003185 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 234621003186 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 234621003187 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 234621003188 classical (c) SDRs; Region: SDR_c; cd05233 234621003189 NAD(P) binding site [chemical binding]; other site 234621003190 active site 234621003191 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 234621003192 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621003193 active site 234621003194 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 234621003195 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621003196 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621003197 active site 234621003198 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 234621003199 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 234621003200 FAD binding site [chemical binding]; other site 234621003201 substrate binding site [chemical binding]; other site 234621003202 catalytic base [active] 234621003203 enoyl-CoA hydratase; Provisional; Region: PRK08290 234621003204 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 234621003205 substrate binding site [chemical binding]; other site 234621003206 oxyanion hole (OAH) forming residues; other site 234621003207 trimer interface [polypeptide binding]; other site 234621003208 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 234621003209 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621003210 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 234621003211 acyl-activating enzyme (AAE) consensus motif; other site 234621003212 putative AMP binding site [chemical binding]; other site 234621003213 putative active site [active] 234621003214 putative CoA binding site [chemical binding]; other site 234621003215 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621003216 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621003217 active site 234621003218 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 234621003219 classical (c) SDRs; Region: SDR_c; cd05233 234621003220 NAD(P) binding site [chemical binding]; other site 234621003221 active site 234621003222 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621003223 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621003224 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 234621003225 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 234621003226 dimer interface [polypeptide binding]; other site 234621003227 active site 234621003228 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 234621003229 Cytochrome P450; Region: p450; pfam00067 234621003230 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 234621003231 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621003232 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621003233 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 234621003234 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 234621003235 intersubunit interface [polypeptide binding]; other site 234621003236 Sodium Bile acid symporter family; Region: SBF; cl17470 234621003237 bile acid transporter; Region: bass; TIGR00841 234621003238 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 234621003239 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 234621003240 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 234621003241 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 234621003242 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 234621003243 mce related protein; Region: MCE; pfam02470 234621003244 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 234621003245 mce related protein; Region: MCE; pfam02470 234621003246 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 234621003247 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 234621003248 mce related protein; Region: MCE; pfam02470 234621003249 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 234621003250 mce related protein; Region: MCE; pfam02470 234621003251 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 234621003252 mce related protein; Region: MCE; pfam02470 234621003253 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 234621003254 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 234621003255 Permease; Region: Permease; pfam02405 234621003256 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 234621003257 Permease; Region: Permease; pfam02405 234621003258 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621003259 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621003260 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621003261 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621003262 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 234621003263 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 234621003264 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 234621003265 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 234621003266 Transcriptional regulator [Transcription]; Region: IclR; COG1414 234621003267 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 234621003268 Nitronate monooxygenase; Region: NMO; pfam03060 234621003269 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 234621003270 FMN binding site [chemical binding]; other site 234621003271 substrate binding site [chemical binding]; other site 234621003272 putative catalytic residue [active] 234621003273 Coenzyme A transferase; Region: CoA_trans; cl17247 234621003274 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 234621003275 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 234621003276 substrate binding site [chemical binding]; other site 234621003277 oxyanion hole (OAH) forming residues; other site 234621003278 trimer interface [polypeptide binding]; other site 234621003279 short chain dehydrogenase; Provisional; Region: PRK07791 234621003280 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621003281 NAD(P) binding site [chemical binding]; other site 234621003282 active site 234621003283 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 234621003284 primary dimer interface [polypeptide binding]; other site 234621003285 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 234621003286 Domain of unknown function (DUF385); Region: DUF385; pfam04075 234621003287 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 234621003288 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 234621003289 dimer interface [polypeptide binding]; other site 234621003290 active site 234621003291 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 234621003292 Cytochrome P450; Region: p450; cl12078 234621003293 ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351 234621003294 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234621003295 metal binding site [ion binding]; metal-binding site 234621003296 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 234621003297 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 234621003298 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 234621003299 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 234621003300 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 234621003301 active site 234621003302 lipid-transfer protein; Provisional; Region: PRK07937 234621003303 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 234621003304 active site 234621003305 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 234621003306 DUF35 OB-fold domain; Region: DUF35; pfam01796 234621003307 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 234621003308 DUF35 OB-fold domain; Region: DUF35; pfam01796 234621003309 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 234621003310 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 234621003311 enoyl-CoA hydratase; Provisional; Region: PRK07799 234621003312 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 234621003313 substrate binding site [chemical binding]; other site 234621003314 oxyanion hole (OAH) forming residues; other site 234621003315 trimer interface [polypeptide binding]; other site 234621003316 acyl-CoA synthetase; Validated; Region: PRK07798 234621003317 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621003318 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 234621003319 acyl-activating enzyme (AAE) consensus motif; other site 234621003320 acyl-activating enzyme (AAE) consensus motif; other site 234621003321 putative AMP binding site [chemical binding]; other site 234621003322 putative active site [active] 234621003323 putative CoA binding site [chemical binding]; other site 234621003324 Nitronate monooxygenase; Region: NMO; pfam03060 234621003325 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 234621003326 FMN binding site [chemical binding]; other site 234621003327 substrate binding site [chemical binding]; other site 234621003328 putative catalytic residue [active] 234621003329 Transcriptional regulators [Transcription]; Region: FadR; COG2186 234621003330 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 234621003331 DNA-binding site [nucleotide binding]; DNA binding site 234621003332 FCD domain; Region: FCD; pfam07729 234621003333 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 234621003334 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 234621003335 Walker A/P-loop; other site 234621003336 ATP binding site [chemical binding]; other site 234621003337 Q-loop/lid; other site 234621003338 ABC transporter signature motif; other site 234621003339 Walker B; other site 234621003340 D-loop; other site 234621003341 H-loop/switch region; other site 234621003342 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 234621003343 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 234621003344 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 234621003345 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234621003346 dimer interface [polypeptide binding]; other site 234621003347 conserved gate region; other site 234621003348 putative PBP binding loops; other site 234621003349 ABC-ATPase subunit interface; other site 234621003350 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 234621003351 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 234621003352 Walker A/P-loop; other site 234621003353 ATP binding site [chemical binding]; other site 234621003354 Q-loop/lid; other site 234621003355 ABC transporter signature motif; other site 234621003356 Walker B; other site 234621003357 D-loop; other site 234621003358 H-loop/switch region; other site 234621003359 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 234621003360 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 234621003361 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234621003362 dimer interface [polypeptide binding]; other site 234621003363 conserved gate region; other site 234621003364 ABC-ATPase subunit interface; other site 234621003365 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 234621003366 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 234621003367 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234621003368 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234621003369 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234621003370 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234621003371 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 234621003372 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234621003373 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234621003374 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 234621003375 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 234621003376 inhibitor site; inhibition site 234621003377 active site 234621003378 dimer interface [polypeptide binding]; other site 234621003379 catalytic residue [active] 234621003380 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 234621003381 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 234621003382 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 234621003383 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 234621003384 putative active site cavity [active] 234621003385 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 234621003386 active site 234621003387 catalytic triad [active] 234621003388 oxyanion hole [active] 234621003389 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 234621003390 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234621003391 active site 234621003392 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 234621003393 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 234621003394 active site 234621003395 trimer interface [polypeptide binding]; other site 234621003396 allosteric site; other site 234621003397 active site lid [active] 234621003398 hexamer (dimer of trimers) interface [polypeptide binding]; other site 234621003399 acyl-CoA synthetase; Validated; Region: PRK07867 234621003400 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621003401 acyl-activating enzyme (AAE) consensus motif; other site 234621003402 AMP binding site [chemical binding]; other site 234621003403 active site 234621003404 CoA binding site [chemical binding]; other site 234621003405 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621003406 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 234621003407 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 234621003408 active site 234621003409 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621003410 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 234621003411 FAD binding site [chemical binding]; other site 234621003412 substrate binding site [chemical binding]; other site 234621003413 catalytic base [active] 234621003414 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 234621003415 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 234621003416 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 234621003417 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621003418 NAD(P) binding site [chemical binding]; other site 234621003419 active site 234621003420 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 234621003421 Permease; Region: Permease; pfam02405 234621003422 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 234621003423 Permease; Region: Permease; pfam02405 234621003424 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 234621003425 mce related protein; Region: MCE; pfam02470 234621003426 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 234621003427 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 234621003428 mce related protein; Region: MCE; pfam02470 234621003429 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 234621003430 mce related protein; Region: MCE; pfam02470 234621003431 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 234621003432 mce related protein; Region: MCE; pfam02470 234621003433 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 234621003434 mce related protein; Region: MCE; pfam02470 234621003435 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 234621003436 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 234621003437 mce related protein; Region: MCE; pfam02470 234621003438 Macrophage killing protein with similarity to conjugation protein; Region: IcmL; pfam11393 234621003439 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 234621003440 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 234621003441 active site 234621003442 homotetramer interface [polypeptide binding]; other site 234621003443 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 234621003444 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 234621003445 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234621003446 Walker A/P-loop; other site 234621003447 ATP binding site [chemical binding]; other site 234621003448 Q-loop/lid; other site 234621003449 ABC transporter signature motif; other site 234621003450 Walker B; other site 234621003451 D-loop; other site 234621003452 H-loop/switch region; other site 234621003453 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 234621003454 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234621003455 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 234621003456 Walker A/P-loop; other site 234621003457 ATP binding site [chemical binding]; other site 234621003458 Q-loop/lid; other site 234621003459 ABC transporter signature motif; other site 234621003460 Walker B; other site 234621003461 D-loop; other site 234621003462 H-loop/switch region; other site 234621003463 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 234621003464 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 234621003465 active site 234621003466 substrate binding site [chemical binding]; other site 234621003467 cosubstrate binding site; other site 234621003468 catalytic site [active] 234621003469 Formyl transferase, C-terminal domain; Region: Formyl_trans_C; pfam02911 234621003470 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 234621003471 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 234621003472 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 234621003473 putative homotetramer interface [polypeptide binding]; other site 234621003474 putative homodimer interface [polypeptide binding]; other site 234621003475 putative allosteric switch controlling residues; other site 234621003476 putative metal binding site [ion binding]; other site 234621003477 putative homodimer-homodimer interface [polypeptide binding]; other site 234621003478 Domain of unknown function DUF302; Region: DUF302; pfam03625 234621003479 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 234621003480 Methyltransferase domain; Region: Methyltransf_23; pfam13489 234621003481 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234621003482 S-adenosylmethionine binding site [chemical binding]; other site 234621003483 Condensation domain; Region: Condensation; pfam00668 234621003484 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 234621003485 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 234621003486 acyl-activating enzyme (AAE) consensus motif; other site 234621003487 AMP binding site [chemical binding]; other site 234621003488 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 234621003489 Condensation domain; Region: Condensation; pfam00668 234621003490 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 234621003491 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 234621003492 Condensation domain; Region: Condensation; pfam00668 234621003493 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 234621003494 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 234621003495 acyl-activating enzyme (AAE) consensus motif; other site 234621003496 AMP binding site [chemical binding]; other site 234621003497 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 234621003498 Condensation domain; Region: Condensation; pfam00668 234621003499 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 234621003500 Condensation domain; Region: Condensation; pfam00668 234621003501 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 234621003502 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 234621003503 acyl-activating enzyme (AAE) consensus motif; other site 234621003504 AMP binding site [chemical binding]; other site 234621003505 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 234621003506 Condensation domain; Region: Condensation; pfam00668 234621003507 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 234621003508 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 234621003509 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 234621003510 acyl-activating enzyme (AAE) consensus motif; other site 234621003511 AMP binding site [chemical binding]; other site 234621003512 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 234621003513 Condensation domain; Region: Condensation; pfam00668 234621003514 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 234621003515 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 234621003516 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 234621003517 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 234621003518 Uncharacterized conserved protein [Function unknown]; Region: COG2966 234621003519 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 234621003520 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 234621003521 GAF domain; Region: GAF; pfam01590 234621003522 GAF domain; Region: GAF_2; pfam13185 234621003523 ANTAR domain; Region: ANTAR; pfam03861 234621003524 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 234621003525 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 234621003526 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234621003527 active site 234621003528 phosphorylation site [posttranslational modification] 234621003529 intermolecular recognition site; other site 234621003530 dimerization interface [polypeptide binding]; other site 234621003531 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 234621003532 DNA binding site [nucleotide binding] 234621003533 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 234621003534 dimerization interface [polypeptide binding]; other site 234621003535 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234621003536 dimer interface [polypeptide binding]; other site 234621003537 phosphorylation site [posttranslational modification] 234621003538 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234621003539 ATP binding site [chemical binding]; other site 234621003540 Mg2+ binding site [ion binding]; other site 234621003541 G-X-G motif; other site 234621003542 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 234621003543 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 234621003544 dimer interface [polypeptide binding]; other site 234621003545 active site 234621003546 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 234621003547 substrate binding site [chemical binding]; other site 234621003548 catalytic residue [active] 234621003549 D-glutamate deacylase; Validated; Region: PRK09061 234621003550 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234621003551 active site 234621003552 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234621003553 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 234621003554 SxDxEG motif; other site 234621003555 active site 234621003556 metal binding site [ion binding]; metal-binding site 234621003557 homopentamer interface [polypeptide binding]; other site 234621003558 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621003559 D-galactonate transporter; Region: 2A0114; TIGR00893 234621003560 putative substrate translocation pore; other site 234621003561 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 234621003562 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 234621003563 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 234621003564 metal binding site [ion binding]; metal-binding site 234621003565 dimer interface [polypeptide binding]; other site 234621003566 Uncharacterized conserved protein [Function unknown]; Region: COG3375 234621003567 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 234621003568 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 234621003569 active site 234621003570 octamer interface [polypeptide binding]; other site 234621003571 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 234621003572 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 234621003573 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 234621003574 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621003575 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621003576 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 234621003577 nucleotide binding site/active site [active] 234621003578 HIT family signature motif; other site 234621003579 catalytic residue [active] 234621003580 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 234621003581 Ligand binding site; other site 234621003582 Ligand binding site; other site 234621003583 Ligand binding site; other site 234621003584 Putative Catalytic site; other site 234621003585 DXD motif; other site 234621003586 GtrA-like protein; Region: GtrA; pfam04138 234621003587 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 234621003588 Domain of unknown function (DUF222); Region: DUF222; pfam02720 234621003589 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 234621003590 active site 234621003591 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 234621003592 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 234621003593 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 234621003594 Walker A/P-loop; other site 234621003595 ATP binding site [chemical binding]; other site 234621003596 Q-loop/lid; other site 234621003597 ABC transporter signature motif; other site 234621003598 Walker B; other site 234621003599 D-loop; other site 234621003600 H-loop/switch region; other site 234621003601 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 234621003602 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 234621003603 Walker A/P-loop; other site 234621003604 ATP binding site [chemical binding]; other site 234621003605 Q-loop/lid; other site 234621003606 ABC transporter signature motif; other site 234621003607 Walker B; other site 234621003608 D-loop; other site 234621003609 H-loop/switch region; other site 234621003610 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 234621003611 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 234621003612 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234621003613 dimer interface [polypeptide binding]; other site 234621003614 conserved gate region; other site 234621003615 putative PBP binding loops; other site 234621003616 ABC-ATPase subunit interface; other site 234621003617 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 234621003618 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234621003619 dimer interface [polypeptide binding]; other site 234621003620 conserved gate region; other site 234621003621 putative PBP binding loops; other site 234621003622 ABC-ATPase subunit interface; other site 234621003623 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 234621003624 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 234621003625 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 234621003626 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 234621003627 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 234621003628 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 234621003629 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 234621003630 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 234621003631 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 234621003632 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 234621003633 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 234621003634 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 234621003635 intersubunit interface [polypeptide binding]; other site 234621003636 MarR family; Region: MarR_2; pfam12802 234621003637 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 234621003638 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 234621003639 siderophore binding site; other site 234621003640 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 234621003641 active site 234621003642 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 234621003643 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234621003644 active site 234621003645 phosphorylation site [posttranslational modification] 234621003646 intermolecular recognition site; other site 234621003647 dimerization interface [polypeptide binding]; other site 234621003648 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 234621003649 DNA binding site [nucleotide binding] 234621003650 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 234621003651 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 234621003652 dimerization interface [polypeptide binding]; other site 234621003653 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234621003654 dimer interface [polypeptide binding]; other site 234621003655 phosphorylation site [posttranslational modification] 234621003656 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234621003657 ATP binding site [chemical binding]; other site 234621003658 Mg2+ binding site [ion binding]; other site 234621003659 G-X-G motif; other site 234621003660 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 234621003661 Beta-lactamase; Region: Beta-lactamase; pfam00144 234621003662 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 234621003663 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234621003664 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234621003665 Beta-lactamase; Region: Beta-lactamase; pfam00144 234621003666 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 234621003667 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 234621003668 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 234621003669 aspartate aminotransferase; Provisional; Region: PRK05764 234621003670 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 234621003671 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234621003672 homodimer interface [polypeptide binding]; other site 234621003673 catalytic residue [active] 234621003674 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 234621003675 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 234621003676 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 234621003677 tetramer interface [polypeptide binding]; other site 234621003678 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 234621003679 HIT family signature motif; other site 234621003680 catalytic residue [active] 234621003681 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 234621003682 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 234621003683 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 234621003684 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 234621003685 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 234621003686 intersubunit interface [polypeptide binding]; other site 234621003687 Histidine kinase; Region: HisKA_3; pfam07730 234621003688 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 234621003689 ATP binding site [chemical binding]; other site 234621003690 Mg2+ binding site [ion binding]; other site 234621003691 G-X-G motif; other site 234621003692 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 234621003693 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234621003694 active site 234621003695 phosphorylation site [posttranslational modification] 234621003696 intermolecular recognition site; other site 234621003697 dimerization interface [polypeptide binding]; other site 234621003698 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 234621003699 DNA binding residues [nucleotide binding] 234621003700 dimerization interface [polypeptide binding]; other site 234621003701 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 234621003702 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 234621003703 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 234621003704 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 234621003705 intersubunit interface [polypeptide binding]; other site 234621003706 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 234621003707 ATP binding site [chemical binding]; other site 234621003708 active site 234621003709 substrate binding site [chemical binding]; other site 234621003710 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 234621003711 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234621003712 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 234621003713 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234621003714 active site 234621003715 phosphorylation site [posttranslational modification] 234621003716 intermolecular recognition site; other site 234621003717 dimerization interface [polypeptide binding]; other site 234621003718 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 234621003719 putative DNA binding site [nucleotide binding]; other site 234621003720 putative Zn2+ binding site [ion binding]; other site 234621003721 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 234621003722 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234621003723 ATP binding site [chemical binding]; other site 234621003724 Mg2+ binding site [ion binding]; other site 234621003725 G-X-G motif; other site 234621003726 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 234621003727 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 234621003728 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621003729 active site 234621003730 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621003731 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 234621003732 active site 234621003733 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 234621003734 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 234621003735 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 234621003736 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 234621003737 siderophore binding site; other site 234621003738 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 234621003739 catalytic residues [active] 234621003740 dimer interface [polypeptide binding]; other site 234621003741 Predicted deacetylase [General function prediction only]; Region: COG3233 234621003742 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 234621003743 putative active site [active] 234621003744 putative Zn binding site [ion binding]; other site 234621003745 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 234621003746 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 234621003747 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 234621003748 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 234621003749 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 234621003750 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 234621003751 putative active site [active] 234621003752 catalytic triad [active] 234621003753 aminotransferase AlaT; Validated; Region: PRK09265 234621003754 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 234621003755 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234621003756 homodimer interface [polypeptide binding]; other site 234621003757 catalytic residue [active] 234621003758 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 234621003759 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 234621003760 DNA-binding site [nucleotide binding]; DNA binding site 234621003761 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 234621003762 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234621003763 homodimer interface [polypeptide binding]; other site 234621003764 catalytic residue [active] 234621003765 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 234621003766 glycosyltransferase, MGT family; Region: MGT; TIGR01426 234621003767 active site 234621003768 TDP-binding site; other site 234621003769 acceptor substrate-binding pocket; other site 234621003770 homodimer interface [polypeptide binding]; other site 234621003771 yiaA/B two helix domain; Region: YiaAB; cl01759 234621003772 HAMP domain; Region: HAMP; pfam00672 234621003773 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 234621003774 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234621003775 dimer interface [polypeptide binding]; other site 234621003776 phosphorylation site [posttranslational modification] 234621003777 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234621003778 ATP binding site [chemical binding]; other site 234621003779 Mg2+ binding site [ion binding]; other site 234621003780 G-X-G motif; other site 234621003781 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 234621003782 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234621003783 active site 234621003784 phosphorylation site [posttranslational modification] 234621003785 intermolecular recognition site; other site 234621003786 dimerization interface [polypeptide binding]; other site 234621003787 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 234621003788 DNA binding site [nucleotide binding] 234621003789 Domain of unknown function (DUF305); Region: DUF305; pfam03713 234621003790 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 234621003791 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 234621003792 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 234621003793 motif II; other site 234621003794 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 234621003795 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 234621003796 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234621003797 Walker A/P-loop; other site 234621003798 ATP binding site [chemical binding]; other site 234621003799 Q-loop/lid; other site 234621003800 ABC transporter signature motif; other site 234621003801 Walker B; other site 234621003802 D-loop; other site 234621003803 H-loop/switch region; other site 234621003804 ABC transporter; Region: ABC_tran_2; pfam12848 234621003805 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 234621003806 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 234621003807 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234621003808 dimer interface [polypeptide binding]; other site 234621003809 putative metal binding site [ion binding]; other site 234621003810 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 234621003811 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 234621003812 MarR family; Region: MarR_2; cl17246 234621003813 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 234621003814 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 234621003815 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 234621003816 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 234621003817 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 234621003818 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 234621003819 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 234621003820 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621003821 putative substrate translocation pore; other site 234621003822 POT family; Region: PTR2; cl17359 234621003823 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 234621003824 YceI-like domain; Region: YceI; smart00867 234621003825 2-isopropylmalate synthase; Validated; Region: PRK03739 234621003826 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 234621003827 active site 234621003828 catalytic residues [active] 234621003829 metal binding site [ion binding]; metal-binding site 234621003830 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 234621003831 Transcriptional regulators [Transcription]; Region: FadR; COG2186 234621003832 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 234621003833 DNA-binding site [nucleotide binding]; DNA binding site 234621003834 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 234621003835 Predicted integral membrane protein [Function unknown]; Region: COG0392 234621003836 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 234621003837 dimerization interface [polypeptide binding]; other site 234621003838 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 234621003839 cyclase homology domain; Region: CHD; cd07302 234621003840 nucleotidyl binding site; other site 234621003841 metal binding site [ion binding]; metal-binding site 234621003842 dimer interface [polypeptide binding]; other site 234621003843 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 234621003844 Domain of unknown function DUF20; Region: UPF0118; pfam01594 234621003845 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234621003846 ATP binding site [chemical binding]; other site 234621003847 Mg2+ binding site [ion binding]; other site 234621003848 G-X-G motif; other site 234621003849 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 234621003850 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234621003851 active site 234621003852 phosphorylation site [posttranslational modification] 234621003853 intermolecular recognition site; other site 234621003854 dimerization interface [polypeptide binding]; other site 234621003855 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 234621003856 DNA binding residues [nucleotide binding] 234621003857 dimerization interface [polypeptide binding]; other site 234621003858 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 234621003859 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 234621003860 putative active site [active] 234621003861 putative catalytic site [active] 234621003862 Cupin domain; Region: Cupin_2; pfam07883 234621003863 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621003864 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621003865 MMPL family; Region: MMPL; pfam03176 234621003866 MMPL family; Region: MMPL; pfam03176 234621003867 LabA_like proteins; Region: LabA_like; cd06167 234621003868 putative metal binding site [ion binding]; other site 234621003869 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234621003870 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 234621003871 active site 234621003872 substrate-binding site [chemical binding]; other site 234621003873 metal-binding site [ion binding] 234621003874 GTP binding site [chemical binding]; other site 234621003875 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 234621003876 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 234621003877 dimer interface [polypeptide binding]; other site 234621003878 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234621003879 catalytic residue [active] 234621003880 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 234621003881 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 234621003882 trimer interface [polypeptide binding]; other site 234621003883 active site 234621003884 substrate binding site [chemical binding]; other site 234621003885 CoA binding site [chemical binding]; other site 234621003886 Cation efflux family; Region: Cation_efflux; pfam01545 234621003887 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 234621003888 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621003889 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621003890 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 234621003891 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 234621003892 ABC-ATPase subunit interface; other site 234621003893 dimer interface [polypeptide binding]; other site 234621003894 putative PBP binding regions; other site 234621003895 proposed F420-0 ABC transporter, ATP-binding protein; Region: F420-0_ABC_ATP; TIGR03873 234621003896 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 234621003897 Walker A/P-loop; other site 234621003898 ATP binding site [chemical binding]; other site 234621003899 Q-loop/lid; other site 234621003900 ABC transporter signature motif; other site 234621003901 Walker B; other site 234621003902 D-loop; other site 234621003903 H-loop/switch region; other site 234621003904 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 234621003905 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 234621003906 intersubunit interface [polypeptide binding]; other site 234621003907 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 234621003908 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 234621003909 dimer interface [polypeptide binding]; other site 234621003910 [2Fe-2S] cluster binding site [ion binding]; other site 234621003911 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 234621003912 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 234621003913 NAD binding site [chemical binding]; other site 234621003914 catalytic residues [active] 234621003915 Phosphotransferase enzyme family; Region: APH; pfam01636 234621003916 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 234621003917 putative active site [active] 234621003918 putative substrate binding site [chemical binding]; other site 234621003919 ATP binding site [chemical binding]; other site 234621003920 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 234621003921 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 234621003922 Methyltransferase domain; Region: Methyltransf_11; pfam08241 234621003923 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 234621003924 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 234621003925 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 234621003926 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 234621003927 intersubunit interface [polypeptide binding]; other site 234621003928 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 234621003929 Acyltransferase family; Region: Acyl_transf_3; pfam01757 234621003930 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 234621003931 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 234621003932 isochorismate synthase EntC; Provisional; Region: PRK15016 234621003933 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 234621003934 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 234621003935 Ligand Binding Site [chemical binding]; other site 234621003936 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 234621003937 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 234621003938 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621003939 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621003940 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 234621003941 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 234621003942 active site 2 [active] 234621003943 active site 1 [active] 234621003944 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 234621003945 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621003946 NAD(P) binding site [chemical binding]; other site 234621003947 active site 234621003948 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 234621003949 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 234621003950 dimer interface [polypeptide binding]; other site 234621003951 active site 234621003952 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 234621003953 VanW like protein; Region: VanW; pfam04294 234621003954 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 234621003955 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 234621003956 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 234621003957 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3575 234621003958 Predicted membrane protein [Function unknown]; Region: COG1511 234621003959 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 234621003960 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 234621003961 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 234621003962 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 234621003963 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 234621003964 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 234621003965 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 234621003966 FAD binding site [chemical binding]; other site 234621003967 substrate binding site [chemical binding]; other site 234621003968 catalytic residues [active] 234621003969 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 234621003970 Methyltransferase domain; Region: Methyltransf_31; pfam13847 234621003971 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234621003972 S-adenosylmethionine binding site [chemical binding]; other site 234621003973 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 234621003974 FtsX-like permease family; Region: FtsX; pfam02687 234621003975 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 234621003976 FtsX-like permease family; Region: FtsX; pfam02687 234621003977 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 234621003978 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 234621003979 Walker A/P-loop; other site 234621003980 ATP binding site [chemical binding]; other site 234621003981 Q-loop/lid; other site 234621003982 ABC transporter signature motif; other site 234621003983 Walker B; other site 234621003984 D-loop; other site 234621003985 H-loop/switch region; other site 234621003986 Putative sensor; Region: Sensor; pfam13796 234621003987 Histidine kinase; Region: HisKA_3; pfam07730 234621003988 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234621003989 ATP binding site [chemical binding]; other site 234621003990 Mg2+ binding site [ion binding]; other site 234621003991 G-X-G motif; other site 234621003992 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 234621003993 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234621003994 phosphorylation site [posttranslational modification] 234621003995 intermolecular recognition site; other site 234621003996 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 234621003997 DNA binding residues [nucleotide binding] 234621003998 dimerization interface [polypeptide binding]; other site 234621003999 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 234621004000 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 234621004001 dimer interface [polypeptide binding]; other site 234621004002 active site 234621004003 CoA binding pocket [chemical binding]; other site 234621004004 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 234621004005 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 234621004006 Uncharacterized conserved protein [Function unknown]; Region: COG3379 234621004007 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 234621004008 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 234621004009 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 234621004010 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234621004011 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 234621004012 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 234621004013 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 234621004014 classical (c) SDRs; Region: SDR_c; cd05233 234621004015 NAD(P) binding site [chemical binding]; other site 234621004016 active site 234621004017 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 234621004018 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 234621004019 Cytochrome P450; Region: p450; cl12078 234621004020 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621004021 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621004022 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 234621004023 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 234621004024 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 234621004025 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 234621004026 helix_turn_helix, mercury resistance; Region: HTH_MERR; smart00422 234621004027 DNA binding residues [nucleotide binding] 234621004028 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 234621004029 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 234621004030 Sulfate transporter family; Region: Sulfate_transp; pfam00916 234621004031 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 234621004032 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 234621004033 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 234621004034 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 234621004035 Domain of unknown function (DUF305); Region: DUF305; pfam03713 234621004036 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621004037 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621004038 GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; Region: GIY-YIG_COG3680; cd10440 234621004039 GIY-YIG motif/motif A; other site 234621004040 putative active site [active] 234621004041 putative metal binding site [ion binding]; other site 234621004042 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 234621004043 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 234621004044 Protein of unknown function (DUF461); Region: DUF461; pfam04314 234621004045 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 234621004046 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 234621004047 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 234621004048 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 234621004049 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 234621004050 P-loop; other site 234621004051 Magnesium ion binding site [ion binding]; other site 234621004052 peptide chain release factor 1, archaeal and eukaryotic forms; Region: aRF1/eRF1; TIGR03676 234621004053 Peptidase family M48; Region: Peptidase_M48; pfam01435 234621004054 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 234621004055 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 234621004056 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 234621004057 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 234621004058 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 234621004059 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 234621004060 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621004061 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 234621004062 NAD(P) binding site [chemical binding]; other site 234621004063 active site 234621004064 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 234621004065 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621004066 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 234621004067 hydrophobic ligand binding site; other site 234621004068 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 234621004069 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 234621004070 NAD binding site [chemical binding]; other site 234621004071 catalytic Zn binding site [ion binding]; other site 234621004072 structural Zn binding site [ion binding]; other site 234621004073 PAS fold; Region: PAS_3; pfam08447 234621004074 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 234621004075 haloalkane dehalogenase; Provisional; Region: PRK03592 234621004076 haloalkane dehalogenase; Provisional; Region: PRK03592 234621004077 MarR family; Region: MarR; pfam01047 234621004078 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 234621004079 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 234621004080 PPOX class probable F420-dependent enzyme, MSMEG_5819 family; Region: PPOX_MSMEG_5819; TIGR04023 234621004081 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 234621004082 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 234621004083 Sulfatase; Region: Sulfatase; pfam00884 234621004084 Sulfatase; Region: Sulfatase; cl17466 234621004085 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 234621004086 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 234621004087 Walker A/P-loop; other site 234621004088 ATP binding site [chemical binding]; other site 234621004089 Q-loop/lid; other site 234621004090 ABC transporter signature motif; other site 234621004091 Walker B; other site 234621004092 D-loop; other site 234621004093 H-loop/switch region; other site 234621004094 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 234621004095 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 234621004096 ABC-ATPase subunit interface; other site 234621004097 dimer interface [polypeptide binding]; other site 234621004098 putative PBP binding regions; other site 234621004099 Methyltransferase domain; Region: Methyltransf_31; pfam13847 234621004100 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234621004101 S-adenosylmethionine binding site [chemical binding]; other site 234621004102 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 234621004103 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 234621004104 intersubunit interface [polypeptide binding]; other site 234621004105 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 234621004106 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 234621004107 FAD binding pocket [chemical binding]; other site 234621004108 FAD binding motif [chemical binding]; other site 234621004109 phosphate binding motif [ion binding]; other site 234621004110 NAD binding pocket [chemical binding]; other site 234621004111 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 234621004112 classical (c) SDRs; Region: SDR_c; cd05233 234621004113 NAD(P) binding site [chemical binding]; other site 234621004114 active site 234621004115 Uncharacterized conserved protein [Function unknown]; Region: COG5361 234621004116 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 234621004117 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 234621004118 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 234621004119 SnoaL-like domain; Region: SnoaL_3; pfam13474 234621004120 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 234621004121 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 234621004122 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 234621004123 homotrimer interaction site [polypeptide binding]; other site 234621004124 putative active site [active] 234621004125 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 234621004126 DNA binding residues [nucleotide binding] 234621004127 putative acyltransferase; Provisional; Region: PRK05790 234621004128 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 234621004129 dimer interface [polypeptide binding]; other site 234621004130 active site 234621004131 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 234621004132 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 234621004133 Transcriptional regulator [Transcription]; Region: IclR; COG1414 234621004134 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 234621004135 Bacterial transcriptional regulator; Region: IclR; pfam01614 234621004136 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 234621004137 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234621004138 sequence-specific DNA binding site [nucleotide binding]; other site 234621004139 salt bridge; other site 234621004140 Cupin domain; Region: Cupin_2; pfam07883 234621004141 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621004142 Major Facilitator Superfamily; Region: MFS_1; pfam07690 234621004143 putative substrate translocation pore; other site 234621004144 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621004145 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 234621004146 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 234621004147 Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile. CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902 234621004148 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 234621004149 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621004150 metabolite-proton symporter; Region: 2A0106; TIGR00883 234621004151 putative substrate translocation pore; other site 234621004152 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 234621004153 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 234621004154 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 234621004155 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 234621004156 putative active site [active] 234621004157 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 234621004158 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 234621004159 putative active site [active] 234621004160 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 234621004161 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 234621004162 active site 234621004163 trimer interface [polypeptide binding]; other site 234621004164 allosteric site; other site 234621004165 active site lid [active] 234621004166 hexamer (dimer of trimers) interface [polypeptide binding]; other site 234621004167 NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]; Region: GltD; COG0493 234621004168 Tyrosine kinase, catalytic domain; Region: TyrKc; smart00219 234621004169 Catalytic domain of Protein Kinases; Region: PKc; cd00180 234621004170 active site 234621004171 ATP binding site [chemical binding]; other site 234621004172 substrate binding site [chemical binding]; other site 234621004173 activation loop (A-loop); other site 234621004174 amphi-Trp domain; Region: amphi-Trp; TIGR04354 234621004175 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 234621004176 metal binding site 2 [ion binding]; metal-binding site 234621004177 putative DNA binding helix; other site 234621004178 metal binding site 1 [ion binding]; metal-binding site 234621004179 dimer interface [polypeptide binding]; other site 234621004180 structural Zn2+ binding site [ion binding]; other site 234621004181 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 234621004182 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 234621004183 dimer interface [polypeptide binding]; other site 234621004184 active site 234621004185 heme binding site [chemical binding]; other site 234621004186 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 234621004187 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 234621004188 nudix motif; other site 234621004189 Universal stress protein family; Region: Usp; pfam00582 234621004190 Ligand Binding Site [chemical binding]; other site 234621004191 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 234621004192 Ligand Binding Site [chemical binding]; other site 234621004193 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 234621004194 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 234621004195 D-pathway; other site 234621004196 Putative ubiquinol binding site [chemical binding]; other site 234621004197 Low-spin heme (heme b) binding site [chemical binding]; other site 234621004198 Putative water exit pathway; other site 234621004199 Binuclear center (heme o3/CuB) [ion binding]; other site 234621004200 K-pathway; other site 234621004201 Putative proton exit pathway; other site 234621004202 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 234621004203 active site 234621004204 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 234621004205 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 234621004206 GAF domain; Region: GAF; pfam01590 234621004207 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 234621004208 Histidine kinase; Region: HisKA_3; pfam07730 234621004209 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234621004210 Mg2+ binding site [ion binding]; other site 234621004211 G-X-G motif; other site 234621004212 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 234621004213 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234621004214 active site 234621004215 phosphorylation site [posttranslational modification] 234621004216 intermolecular recognition site; other site 234621004217 dimerization interface [polypeptide binding]; other site 234621004218 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 234621004219 DNA binding residues [nucleotide binding] 234621004220 dimerization interface [polypeptide binding]; other site 234621004221 Domain of unknown function (DUF385); Region: DUF385; cl04387 234621004222 Predicted transcriptional regulators [Transcription]; Region: COG1733 234621004223 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 234621004224 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621004225 putative substrate translocation pore; other site 234621004226 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 234621004227 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 234621004228 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 234621004229 metal binding site [ion binding]; metal-binding site 234621004230 putative dimer interface [polypeptide binding]; other site 234621004231 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 234621004232 FAD binding domain; Region: FAD_binding_4; pfam01565 234621004233 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12845 234621004234 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 234621004235 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 234621004236 Peptidase family M23; Region: Peptidase_M23; pfam01551 234621004237 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 234621004238 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 234621004239 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 234621004240 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 234621004241 putative dimer interface [polypeptide binding]; other site 234621004242 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 234621004243 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 234621004244 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 234621004245 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 234621004246 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 234621004247 Walker A/P-loop; other site 234621004248 ATP binding site [chemical binding]; other site 234621004249 Q-loop/lid; other site 234621004250 ABC transporter signature motif; other site 234621004251 Walker B; other site 234621004252 D-loop; other site 234621004253 H-loop/switch region; other site 234621004254 Predicted transcriptional regulators [Transcription]; Region: COG1725 234621004255 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 234621004256 DNA-binding site [nucleotide binding]; DNA binding site 234621004257 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 234621004258 trimer interface [polypeptide binding]; other site 234621004259 active site 234621004260 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 234621004261 Bacterial transcriptional regulator; Region: IclR; pfam01614 234621004262 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 234621004263 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 234621004264 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 234621004265 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 234621004266 homotrimer interaction site [polypeptide binding]; other site 234621004267 putative active site [active] 234621004268 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 234621004269 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 234621004270 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234621004271 S-adenosylmethionine binding site [chemical binding]; other site 234621004272 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 234621004273 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621004274 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 234621004275 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 234621004276 active site 234621004277 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 234621004278 GAF domain; Region: GAF; pfam01590 234621004279 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 234621004280 putative methyltransferase; Provisional; Region: PRK14967 234621004281 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234621004282 S-adenosylmethionine binding site [chemical binding]; other site 234621004283 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 234621004284 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 234621004285 DNA-binding site [nucleotide binding]; DNA binding site 234621004286 RNA-binding motif; other site 234621004287 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 234621004288 anti sigma factor interaction site; other site 234621004289 regulatory phosphorylation site [posttranslational modification]; other site 234621004290 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 234621004291 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234621004292 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 234621004293 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234621004294 DNA binding residues [nucleotide binding] 234621004295 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 234621004296 Transcription factor WhiB; Region: Whib; pfam02467 234621004297 PAS fold; Region: PAS_4; pfam08448 234621004298 ANTAR domain; Region: ANTAR; pfam03861 234621004299 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 234621004300 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 234621004301 dimerization interface [polypeptide binding]; other site 234621004302 DPS ferroxidase diiron center [ion binding]; other site 234621004303 ion pore; other site 234621004304 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 234621004305 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 234621004306 DNA binding residues [nucleotide binding] 234621004307 putative dimer interface [polypeptide binding]; other site 234621004308 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 234621004309 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 234621004310 active site 234621004311 homotetramer interface [polypeptide binding]; other site 234621004312 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 234621004313 anti sigma factor interaction site; other site 234621004314 regulatory phosphorylation site [posttranslational modification]; other site 234621004315 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 234621004316 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234621004317 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234621004318 DNA binding residues [nucleotide binding] 234621004319 Asp23 family; Region: Asp23; pfam03780 234621004320 Asp23 family; Region: Asp23; cl00574 234621004321 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 234621004322 CsbD-like; Region: CsbD; pfam05532 234621004323 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 234621004324 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 234621004325 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 234621004326 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 234621004327 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 234621004328 active site 234621004329 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234621004330 salt bridge; other site 234621004331 non-specific DNA binding site [nucleotide binding]; other site 234621004332 sequence-specific DNA binding site [nucleotide binding]; other site 234621004333 CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427 234621004334 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 234621004335 DXD motif; other site 234621004336 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 234621004337 Bacterial sugar transferase; Region: Bac_transf; pfam02397 234621004338 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 234621004339 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 234621004340 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 234621004341 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 234621004342 active site 234621004343 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 234621004344 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 234621004345 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 234621004346 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 234621004347 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 234621004348 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 234621004349 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 234621004350 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 234621004351 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 234621004352 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 234621004353 Chain length determinant protein; Region: Wzz; cl15801 234621004354 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 234621004355 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 234621004356 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 234621004357 Bacterial sugar transferase; Region: Bac_transf; pfam02397 234621004358 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 234621004359 O-Antigen ligase; Region: Wzy_C; pfam04932 234621004360 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 234621004361 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 234621004362 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 234621004363 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 234621004364 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 234621004365 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 234621004366 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 234621004367 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 234621004368 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 234621004369 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 234621004370 NADP-binding site; other site 234621004371 homotetramer interface [polypeptide binding]; other site 234621004372 substrate binding site [chemical binding]; other site 234621004373 homodimer interface [polypeptide binding]; other site 234621004374 active site 234621004375 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 234621004376 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 234621004377 NADP binding site [chemical binding]; other site 234621004378 active site 234621004379 putative substrate binding site [chemical binding]; other site 234621004380 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 234621004381 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 234621004382 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 234621004383 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 234621004384 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 234621004385 Chain length determinant protein; Region: Wzz; cl15801 234621004386 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 234621004387 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 234621004388 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 234621004389 NAD binding site [chemical binding]; other site 234621004390 Low molecular weight phosphatase family; Region: LMWPc; cd00115 234621004391 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 234621004392 active site 234621004393 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 234621004394 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 234621004395 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 234621004396 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 234621004397 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 234621004398 nucleotide binding site [chemical binding]; other site 234621004399 variable surface protein Vir28; Provisional; Region: PTZ00249 234621004400 YibE/F-like protein; Region: YibE_F; pfam07907 234621004401 aminotransferase AlaT; Validated; Region: PRK09265 234621004402 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 234621004403 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234621004404 homodimer interface [polypeptide binding]; other site 234621004405 catalytic residue [active] 234621004406 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 234621004407 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234621004408 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 234621004409 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 234621004410 4Fe-4S binding domain; Region: Fer4; pfam00037 234621004411 Cysteine-rich domain; Region: CCG; pfam02754 234621004412 Cysteine-rich domain; Region: CCG; pfam02754 234621004413 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 234621004414 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 234621004415 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 234621004416 DNA binding residues [nucleotide binding] 234621004417 dimerization interface [polypeptide binding]; other site 234621004418 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 234621004419 nucleotide binding site [chemical binding]; other site 234621004420 SBD interface [polypeptide binding]; other site 234621004421 putative NEF/HSP70 interaction site [polypeptide binding]; other site 234621004422 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 234621004423 Dynamin family; Region: Dynamin_N; pfam00350 234621004424 G1 box; other site 234621004425 GTP/Mg2+ binding site [chemical binding]; other site 234621004426 G2 box; other site 234621004427 Switch I region; other site 234621004428 G3 box; other site 234621004429 Switch II region; other site 234621004430 G4 box; other site 234621004431 G5 box; other site 234621004432 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 234621004433 Dynamin family; Region: Dynamin_N; pfam00350 234621004434 G1 box; other site 234621004435 GTP/Mg2+ binding site [chemical binding]; other site 234621004436 G2 box; other site 234621004437 Switch I region; other site 234621004438 G3 box; other site 234621004439 Switch II region; other site 234621004440 G4 box; other site 234621004441 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 234621004442 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621004443 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 234621004444 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 234621004445 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 234621004446 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 234621004447 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 234621004448 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 234621004449 nucleotide binding site [chemical binding]; other site 234621004450 NEF interaction site [polypeptide binding]; other site 234621004451 SBD interface [polypeptide binding]; other site 234621004452 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 234621004453 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 234621004454 dimer interface [polypeptide binding]; other site 234621004455 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 234621004456 chaperone protein DnaJ; Provisional; Region: PRK14279 234621004457 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 234621004458 HSP70 interaction site [polypeptide binding]; other site 234621004459 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 234621004460 Zn binding sites [ion binding]; other site 234621004461 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 234621004462 dimer interface [polypeptide binding]; other site 234621004463 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 234621004464 DNA binding residues [nucleotide binding] 234621004465 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 234621004466 putative dimer interface [polypeptide binding]; other site 234621004467 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 234621004468 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 234621004469 ligand binding site [chemical binding]; other site 234621004470 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 234621004471 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 234621004472 TM-ABC transporter signature motif; other site 234621004473 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 234621004474 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 234621004475 TM-ABC transporter signature motif; other site 234621004476 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 234621004477 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 234621004478 Walker A/P-loop; other site 234621004479 ATP binding site [chemical binding]; other site 234621004480 Q-loop/lid; other site 234621004481 ABC transporter signature motif; other site 234621004482 Walker B; other site 234621004483 D-loop; other site 234621004484 H-loop/switch region; other site 234621004485 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 234621004486 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 234621004487 Walker A/P-loop; other site 234621004488 ATP binding site [chemical binding]; other site 234621004489 Q-loop/lid; other site 234621004490 ABC transporter signature motif; other site 234621004491 Walker B; other site 234621004492 D-loop; other site 234621004493 H-loop/switch region; other site 234621004494 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 234621004495 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 234621004496 active site 234621004497 FMN binding site [chemical binding]; other site 234621004498 substrate binding site [chemical binding]; other site 234621004499 putative catalytic residue [active] 234621004500 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 234621004501 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234621004502 active site 234621004503 phosphorylation site [posttranslational modification] 234621004504 intermolecular recognition site; other site 234621004505 dimerization interface [polypeptide binding]; other site 234621004506 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 234621004507 DNA binding residues [nucleotide binding] 234621004508 dimerization interface [polypeptide binding]; other site 234621004509 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 234621004510 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 234621004511 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 234621004512 classical (c) SDRs; Region: SDR_c; cd05233 234621004513 NAD(P) binding site [chemical binding]; other site 234621004514 active site 234621004515 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 234621004516 classical (c) SDRs; Region: SDR_c; cd05233 234621004517 NAD(P) binding site [chemical binding]; other site 234621004518 active site 234621004519 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 234621004520 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 234621004521 uridine kinase; Validated; Region: PRK06696 234621004522 AAA domain; Region: AAA_18; pfam13238 234621004523 active site 234621004524 flavodoxin; Provisional; Region: PRK06242 234621004525 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 234621004526 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 234621004527 Predicted transcriptional regulators [Transcription]; Region: COG1695 234621004528 Transcriptional regulator PadR-like family; Region: PadR; cl17335 234621004529 Transcriptional regulator [Transcription]; Region: IclR; COG1414 234621004530 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 234621004531 Bacterial transcriptional regulator; Region: IclR; pfam01614 234621004532 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 234621004533 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 234621004534 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 234621004535 active site 234621004536 Fe binding site [ion binding]; other site 234621004537 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621004538 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621004539 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 234621004540 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 234621004541 acyl-CoA synthetase; Validated; Region: PRK06188 234621004542 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621004543 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 234621004544 acyl-activating enzyme (AAE) consensus motif; other site 234621004545 putative AMP binding site [chemical binding]; other site 234621004546 putative active site [active] 234621004547 putative CoA binding site [chemical binding]; other site 234621004548 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 234621004549 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234621004550 active site 234621004551 phosphorylation site [posttranslational modification] 234621004552 intermolecular recognition site; other site 234621004553 dimerization interface [polypeptide binding]; other site 234621004554 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 234621004555 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 234621004556 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 234621004557 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234621004558 ATP binding site [chemical binding]; other site 234621004559 Mg2+ binding site [ion binding]; other site 234621004560 G-X-G motif; other site 234621004561 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 234621004562 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 234621004563 Citrate transporter; Region: CitMHS; pfam03600 234621004564 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575 234621004565 active site 234621004566 dimer interface [polypeptide binding]; other site 234621004567 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 234621004568 heme-binding site [chemical binding]; other site 234621004569 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 234621004570 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 234621004571 FAD binding pocket [chemical binding]; other site 234621004572 FAD binding motif [chemical binding]; other site 234621004573 phosphate binding motif [ion binding]; other site 234621004574 beta-alpha-beta structure motif; other site 234621004575 NAD binding pocket [chemical binding]; other site 234621004576 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 234621004577 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 234621004578 FAD binding pocket [chemical binding]; other site 234621004579 FAD binding motif [chemical binding]; other site 234621004580 phosphate binding motif [ion binding]; other site 234621004581 beta-alpha-beta structure motif; other site 234621004582 NAD binding pocket [chemical binding]; other site 234621004583 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 234621004584 heme-binding site [chemical binding]; other site 234621004585 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 234621004586 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 234621004587 FAD binding pocket [chemical binding]; other site 234621004588 FAD binding motif [chemical binding]; other site 234621004589 phosphate binding motif [ion binding]; other site 234621004590 beta-alpha-beta structure motif; other site 234621004591 NAD binding pocket [chemical binding]; other site 234621004592 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 234621004593 Clp amino terminal domain; Region: Clp_N; pfam02861 234621004594 Clp amino terminal domain; Region: Clp_N; pfam02861 234621004595 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234621004596 Walker A motif; other site 234621004597 ATP binding site [chemical binding]; other site 234621004598 Walker B motif; other site 234621004599 arginine finger; other site 234621004600 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234621004601 Walker A motif; other site 234621004602 ATP binding site [chemical binding]; other site 234621004603 Walker B motif; other site 234621004604 arginine finger; other site 234621004605 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 234621004606 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 234621004607 classical (c) SDRs; Region: SDR_c; cd05233 234621004608 NAD(P) binding site [chemical binding]; other site 234621004609 active site 234621004610 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 234621004611 active site 234621004612 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621004613 Major Facilitator Superfamily; Region: MFS_1; pfam07690 234621004614 putative substrate translocation pore; other site 234621004615 MarR family; Region: MarR; pfam01047 234621004616 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621004617 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621004618 WHG domain; Region: WHG; pfam13305 234621004619 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 234621004620 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 234621004621 putative acyl-acceptor binding pocket; other site 234621004622 YhhN-like protein; Region: YhhN; pfam07947 234621004623 short chain dehydrogenase; Provisional; Region: PRK08267 234621004624 classical (c) SDR, subgroup 9; Region: SDR_c9; cd08931 234621004625 putative NAD(P) binding site [chemical binding]; other site 234621004626 active site 234621004627 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 234621004628 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 234621004629 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 234621004630 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 234621004631 Coenzyme A binding pocket [chemical binding]; other site 234621004632 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 234621004633 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 234621004634 active site 234621004635 non-prolyl cis peptide bond; other site 234621004636 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 234621004637 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 234621004638 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 234621004639 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 234621004640 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 234621004641 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 234621004642 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 234621004643 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 234621004644 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 234621004645 active site 234621004646 intersubunit interface [polypeptide binding]; other site 234621004647 zinc binding site [ion binding]; other site 234621004648 Na+ binding site [ion binding]; other site 234621004649 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 234621004650 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 234621004651 Predicted membrane protein [Function unknown]; Region: COG4129 234621004652 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 234621004653 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 234621004654 Predicted transcriptional regulator [Transcription]; Region: COG2378 234621004655 HTH domain; Region: HTH_11; pfam08279 234621004656 WYL domain; Region: WYL; pfam13280 234621004657 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 234621004658 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234621004659 S-adenosylmethionine binding site [chemical binding]; other site 234621004660 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 234621004661 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 234621004662 dimer interface [polypeptide binding]; other site 234621004663 active site 234621004664 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621004665 Major Facilitator Superfamily; Region: MFS_1; pfam07690 234621004666 putative substrate translocation pore; other site 234621004667 Predicted transcriptional regulators [Transcription]; Region: COG1733 234621004668 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 234621004669 Domain of unknown function (DUF222); Region: DUF222; pfam02720 234621004670 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 234621004671 active site 234621004672 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 234621004673 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 234621004674 Coenzyme A binding pocket [chemical binding]; other site 234621004675 Peptidase family M50; Region: Peptidase_M50; pfam02163 234621004676 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 234621004677 active site 234621004678 putative substrate binding region [chemical binding]; other site 234621004679 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 234621004680 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 234621004681 GDP-binding site [chemical binding]; other site 234621004682 ACT binding site; other site 234621004683 IMP binding site; other site 234621004684 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 234621004685 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 234621004686 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 234621004687 DNA-binding site [nucleotide binding]; DNA binding site 234621004688 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 234621004689 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234621004690 homodimer interface [polypeptide binding]; other site 234621004691 catalytic residue [active] 234621004692 Methyltransferase domain; Region: Methyltransf_31; pfam13847 234621004693 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234621004694 S-adenosylmethionine binding site [chemical binding]; other site 234621004695 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 234621004696 CoA-transferase family III; Region: CoA_transf_3; pfam02515 234621004697 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 234621004698 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 234621004699 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 234621004700 Walker A/P-loop; other site 234621004701 ATP binding site [chemical binding]; other site 234621004702 Q-loop/lid; other site 234621004703 ABC transporter signature motif; other site 234621004704 Walker B; other site 234621004705 D-loop; other site 234621004706 H-loop/switch region; other site 234621004707 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 234621004708 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 234621004709 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234621004710 Walker A/P-loop; other site 234621004711 ATP binding site [chemical binding]; other site 234621004712 Q-loop/lid; other site 234621004713 ABC transporter signature motif; other site 234621004714 Walker B; other site 234621004715 D-loop; other site 234621004716 H-loop/switch region; other site 234621004717 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 234621004718 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 234621004719 metal binding site [ion binding]; metal-binding site 234621004720 active site 234621004721 I-site; other site 234621004722 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 234621004723 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621004724 ATP-grasp domain; Region: ATP-grasp; pfam02222 234621004725 Protein of unknown function (DUF456); Region: DUF456; pfam04306 234621004726 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 234621004727 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234621004728 active site 234621004729 ferredoxin-NADP+ reductase; Region: PLN02852 234621004730 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 234621004731 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 234621004732 active site residue [active] 234621004733 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 234621004734 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 234621004735 homodimer interface [polypeptide binding]; other site 234621004736 substrate-cofactor binding pocket; other site 234621004737 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234621004738 catalytic residue [active] 234621004739 alternate signal-mediated exported protein, RER_14450 family; Region: exp_by_SipW_III; TIGR04089 234621004740 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 234621004741 Catalytic site [active] 234621004742 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 234621004743 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 234621004744 Catalytic site [active] 234621004745 type III secretion system protein; Provisional; Region: PRK15384; cl14665 234621004746 alternate signal-mediated exported protein, RER_14450 family; Region: exp_by_SipW_III; TIGR04089 234621004747 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 234621004748 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 234621004749 active site 234621004750 motif I; other site 234621004751 motif II; other site 234621004752 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 234621004753 active site 234621004754 motif I; other site 234621004755 motif II; other site 234621004756 hypothetical protein; Provisional; Region: PRK10621 234621004757 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 234621004758 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 234621004759 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234621004760 dimer interface [polypeptide binding]; other site 234621004761 conserved gate region; other site 234621004762 putative PBP binding loops; other site 234621004763 ABC-ATPase subunit interface; other site 234621004764 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 234621004765 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 234621004766 Walker A/P-loop; other site 234621004767 ATP binding site [chemical binding]; other site 234621004768 Q-loop/lid; other site 234621004769 ABC transporter signature motif; other site 234621004770 Walker B; other site 234621004771 D-loop; other site 234621004772 H-loop/switch region; other site 234621004773 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 234621004774 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 234621004775 substrate binding pocket [chemical binding]; other site 234621004776 membrane-bound complex binding site; other site 234621004777 hinge residues; other site 234621004778 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 234621004779 hydroxyglutarate oxidase; Provisional; Region: PRK11728 234621004780 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 234621004781 Coenzyme A binding pocket [chemical binding]; other site 234621004782 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 234621004783 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 234621004784 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 234621004785 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234621004786 dimer interface [polypeptide binding]; other site 234621004787 conserved gate region; other site 234621004788 putative PBP binding loops; other site 234621004789 ABC-ATPase subunit interface; other site 234621004790 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 234621004791 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234621004792 dimer interface [polypeptide binding]; other site 234621004793 conserved gate region; other site 234621004794 putative PBP binding loops; other site 234621004795 ABC-ATPase subunit interface; other site 234621004796 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 234621004797 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 234621004798 Walker A/P-loop; other site 234621004799 ATP binding site [chemical binding]; other site 234621004800 Q-loop/lid; other site 234621004801 ABC transporter signature motif; other site 234621004802 Walker B; other site 234621004803 D-loop; other site 234621004804 H-loop/switch region; other site 234621004805 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 234621004806 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 234621004807 Walker A/P-loop; other site 234621004808 ATP binding site [chemical binding]; other site 234621004809 Q-loop/lid; other site 234621004810 ABC transporter signature motif; other site 234621004811 Walker B; other site 234621004812 D-loop; other site 234621004813 H-loop/switch region; other site 234621004814 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 234621004815 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 234621004816 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 234621004817 active site 234621004818 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 234621004819 non-prolyl cis peptide bond; other site 234621004820 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 234621004821 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 234621004822 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 234621004823 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 234621004824 nucleoside/Zn binding site; other site 234621004825 dimer interface [polypeptide binding]; other site 234621004826 catalytic motif [active] 234621004827 Putative esterase; Region: Esterase; pfam00756 234621004828 RDD family; Region: RDD; pfam06271 234621004829 Domain of unknown function (DUF202); Region: DUF202; cl09954 234621004830 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 234621004831 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 234621004832 phosphate acetyltransferase; Reviewed; Region: PRK05632 234621004833 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 234621004834 DRTGG domain; Region: DRTGG; pfam07085 234621004835 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 234621004836 propionate/acetate kinase; Provisional; Region: PRK12379 234621004837 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 234621004838 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234621004839 Catalytic domain of Protein Kinases; Region: PKc; cd00180 234621004840 active site 234621004841 ATP binding site [chemical binding]; other site 234621004842 substrate binding site [chemical binding]; other site 234621004843 activation loop (A-loop); other site 234621004844 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 234621004845 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 234621004846 substrate binding pocket [chemical binding]; other site 234621004847 membrane-bound complex binding site; other site 234621004848 hinge residues; other site 234621004849 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 234621004850 nudix motif; other site 234621004851 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 234621004852 active site 234621004853 thiamine phosphate binding site [chemical binding]; other site 234621004854 pyrophosphate binding site [ion binding]; other site 234621004855 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 234621004856 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 234621004857 thiS-thiF/thiG interaction site; other site 234621004858 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 234621004859 ThiS interaction site; other site 234621004860 putative active site [active] 234621004861 tetramer interface [polypeptide binding]; other site 234621004862 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 234621004863 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 234621004864 Walker A/P-loop; other site 234621004865 ATP binding site [chemical binding]; other site 234621004866 Q-loop/lid; other site 234621004867 ABC transporter signature motif; other site 234621004868 Walker B; other site 234621004869 D-loop; other site 234621004870 H-loop/switch region; other site 234621004871 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 234621004872 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 234621004873 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 234621004874 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 234621004875 PA/protease or protease-like domain interface [polypeptide binding]; other site 234621004876 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 234621004877 Peptidase family M28; Region: Peptidase_M28; pfam04389 234621004878 active site 234621004879 metal binding site [ion binding]; metal-binding site 234621004880 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 234621004881 cyclase homology domain; Region: CHD; cd07302 234621004882 nucleotidyl binding site; other site 234621004883 metal binding site [ion binding]; metal-binding site 234621004884 dimer interface [polypeptide binding]; other site 234621004885 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 234621004886 dimer interface [polypeptide binding]; other site 234621004887 substrate binding site [chemical binding]; other site 234621004888 ATP binding site [chemical binding]; other site 234621004889 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 234621004890 ThiC-associated domain; Region: ThiC-associated; pfam13667 234621004891 ThiC family; Region: ThiC; pfam01964 234621004892 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 234621004893 Coenzyme A binding pocket [chemical binding]; other site 234621004894 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 234621004895 putative catalytic site [active] 234621004896 putative phosphate binding site [ion binding]; other site 234621004897 active site 234621004898 metal binding site A [ion binding]; metal-binding site 234621004899 DNA binding site [nucleotide binding] 234621004900 putative AP binding site [nucleotide binding]; other site 234621004901 putative metal binding site B [ion binding]; other site 234621004902 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 234621004903 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 234621004904 Coenzyme A binding pocket [chemical binding]; other site 234621004905 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 234621004906 active site 234621004907 catalytic residues [active] 234621004908 metal binding site [ion binding]; metal-binding site 234621004909 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 234621004910 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 234621004911 E-class dimer interface [polypeptide binding]; other site 234621004912 P-class dimer interface [polypeptide binding]; other site 234621004913 active site 234621004914 Cu2+ binding site [ion binding]; other site 234621004915 Zn2+ binding site [ion binding]; other site 234621004916 carboxylate-amine ligase; Provisional; Region: PRK13517 234621004917 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 234621004918 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 234621004919 active site 234621004920 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 234621004921 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK07948 234621004922 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 234621004923 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 234621004924 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 234621004925 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 234621004926 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 234621004927 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 234621004928 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 234621004929 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 234621004930 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 234621004931 nudix motif; other site 234621004932 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621004933 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621004934 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 234621004935 Cytochrome P450; Region: p450; cl12078 234621004936 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 234621004937 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 234621004938 tetramer interface [polypeptide binding]; other site 234621004939 active site 234621004940 Mg2+/Mn2+ binding site [ion binding]; other site 234621004941 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 234621004942 Domain of unknown function (DUF222); Region: DUF222; pfam02720 234621004943 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 234621004944 active site 234621004945 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 234621004946 Phosphotransferase enzyme family; Region: APH; pfam01636 234621004947 active site 234621004948 substrate binding site [chemical binding]; other site 234621004949 ATP binding site [chemical binding]; other site 234621004950 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 234621004951 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 234621004952 active site 234621004953 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 234621004954 Cell division protein 48 (CDC48) N-terminal domain; Region: CDC48_N; smart01073 234621004955 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 234621004956 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234621004957 Walker A motif; other site 234621004958 ATP binding site [chemical binding]; other site 234621004959 Walker B motif; other site 234621004960 arginine finger; other site 234621004961 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234621004962 Walker A motif; other site 234621004963 ATP binding site [chemical binding]; other site 234621004964 Walker B motif; other site 234621004965 arginine finger; other site 234621004966 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 234621004967 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 234621004968 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 234621004969 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 234621004970 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 234621004971 DNA binding residues [nucleotide binding] 234621004972 drug binding residues [chemical binding]; other site 234621004973 dimer interface [polypeptide binding]; other site 234621004974 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 234621004975 beta-clamp/clamp loader binding surface; other site 234621004976 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 234621004977 hydrophobic ligand binding site; other site 234621004978 putative proline-specific permease; Provisional; Region: proY; PRK10580 234621004979 Spore germination protein; Region: Spore_permease; cl17796 234621004980 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 234621004981 hydroxyglutarate oxidase; Provisional; Region: PRK11728 234621004982 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 234621004983 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 234621004984 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 234621004985 active site 234621004986 motif I; other site 234621004987 motif II; other site 234621004988 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 234621004989 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 234621004990 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 234621004991 ring oligomerisation interface [polypeptide binding]; other site 234621004992 ATP/Mg binding site [chemical binding]; other site 234621004993 stacking interactions; other site 234621004994 hinge regions; other site 234621004995 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 234621004996 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 234621004997 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 234621004998 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 234621004999 PspC domain; Region: PspC; pfam04024 234621005000 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 234621005001 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 234621005002 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 234621005003 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234621005004 Predicted esterase [General function prediction only]; Region: COG0627 234621005005 Putative esterase; Region: Esterase; pfam00756 234621005006 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234621005007 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 234621005008 active site 234621005009 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 234621005010 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 234621005011 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 234621005012 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 234621005013 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 234621005014 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 234621005015 siderophore binding site; other site 234621005016 Predicted transcriptional regulators [Transcription]; Region: COG1733 234621005017 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 234621005018 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 234621005019 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 234621005020 NADP binding site [chemical binding]; other site 234621005021 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 234621005022 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621005023 putative substrate translocation pore; other site 234621005024 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621005025 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621005026 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621005027 allophanate hydrolase; Provisional; Region: PRK08186 234621005028 Amidase; Region: Amidase; cl11426 234621005029 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 234621005030 Transcriptional regulators [Transcription]; Region: GntR; COG1802 234621005031 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 234621005032 DNA-binding site [nucleotide binding]; DNA binding site 234621005033 FCD domain; Region: FCD; pfam07729 234621005034 Uncharacterized conserved protein [Function unknown]; Region: COG2128 234621005035 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 234621005036 classical (c) SDRs; Region: SDR_c; cd05233 234621005037 NAD(P) binding site [chemical binding]; other site 234621005038 active site 234621005039 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 234621005040 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 234621005041 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 234621005042 Catalytic site [active] 234621005043 Transcriptional regulators [Transcription]; Region: GntR; COG1802 234621005044 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 234621005045 DNA-binding site [nucleotide binding]; DNA binding site 234621005046 FCD domain; Region: FCD; pfam07729 234621005047 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 234621005048 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 234621005049 Walker A/P-loop; other site 234621005050 ATP binding site [chemical binding]; other site 234621005051 Q-loop/lid; other site 234621005052 ABC transporter signature motif; other site 234621005053 Walker B; other site 234621005054 D-loop; other site 234621005055 H-loop/switch region; other site 234621005056 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 234621005057 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 234621005058 Walker A/P-loop; other site 234621005059 ATP binding site [chemical binding]; other site 234621005060 Q-loop/lid; other site 234621005061 ABC transporter signature motif; other site 234621005062 Walker B; other site 234621005063 D-loop; other site 234621005064 H-loop/switch region; other site 234621005065 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 234621005066 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 234621005067 TM-ABC transporter signature motif; other site 234621005068 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 234621005069 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 234621005070 TM-ABC transporter signature motif; other site 234621005071 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 234621005072 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 234621005073 putative ligand binding site [chemical binding]; other site 234621005074 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621005075 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621005076 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 234621005077 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 234621005078 ligand binding site [chemical binding]; other site 234621005079 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 234621005080 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 234621005081 TM-ABC transporter signature motif; other site 234621005082 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 234621005083 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 234621005084 TM-ABC transporter signature motif; other site 234621005085 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 234621005086 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 234621005087 Walker A/P-loop; other site 234621005088 ATP binding site [chemical binding]; other site 234621005089 Q-loop/lid; other site 234621005090 ABC transporter signature motif; other site 234621005091 Walker B; other site 234621005092 D-loop; other site 234621005093 H-loop/switch region; other site 234621005094 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 234621005095 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 234621005096 Walker A/P-loop; other site 234621005097 ATP binding site [chemical binding]; other site 234621005098 Q-loop/lid; other site 234621005099 ABC transporter signature motif; other site 234621005100 Walker B; other site 234621005101 D-loop; other site 234621005102 H-loop/switch region; other site 234621005103 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 234621005104 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621005105 acyl-activating enzyme (AAE) consensus motif; other site 234621005106 AMP binding site [chemical binding]; other site 234621005107 active site 234621005108 CoA binding site [chemical binding]; other site 234621005109 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 234621005110 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 234621005111 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 234621005112 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 234621005113 substrate binding pocket [chemical binding]; other site 234621005114 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 234621005115 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234621005116 non-specific DNA binding site [nucleotide binding]; other site 234621005117 salt bridge; other site 234621005118 sequence-specific DNA binding site [nucleotide binding]; other site 234621005119 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 234621005120 Domain of unknown function (DUF955); Region: DUF955; pfam06114 234621005121 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 234621005122 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 234621005123 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 234621005124 isocitrate lyase; Provisional; Region: PRK15063 234621005125 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 234621005126 tetramer interface [polypeptide binding]; other site 234621005127 active site 234621005128 Mg2+/Mn2+ binding site [ion binding]; other site 234621005129 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 234621005130 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 234621005131 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 234621005132 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 234621005133 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 234621005134 THF binding site; other site 234621005135 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 234621005136 substrate binding site [chemical binding]; other site 234621005137 THF binding site; other site 234621005138 zinc-binding site [ion binding]; other site 234621005139 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 234621005140 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 234621005141 putative NAD(P) binding site [chemical binding]; other site 234621005142 putative substrate binding site [chemical binding]; other site 234621005143 catalytic Zn binding site [ion binding]; other site 234621005144 structural Zn binding site [ion binding]; other site 234621005145 dimer interface [polypeptide binding]; other site 234621005146 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 234621005147 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234621005148 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 234621005149 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234621005150 DNA binding residues [nucleotide binding] 234621005151 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 234621005152 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 234621005153 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 234621005154 anti sigma factor interaction site; other site 234621005155 regulatory phosphorylation site [posttranslational modification]; other site 234621005156 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 234621005157 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 234621005158 putative ADP-binding pocket [chemical binding]; other site 234621005159 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 234621005160 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621005161 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621005162 Predicted membrane protein [Function unknown]; Region: COG2733 234621005163 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 234621005164 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234621005165 non-specific DNA binding site [nucleotide binding]; other site 234621005166 salt bridge; other site 234621005167 sequence-specific DNA binding site [nucleotide binding]; other site 234621005168 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 234621005169 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 234621005170 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 234621005171 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 234621005172 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234621005173 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 234621005174 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 234621005175 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 234621005176 putative active site [active] 234621005177 putative substrate binding site [chemical binding]; other site 234621005178 putative cosubstrate binding site; other site 234621005179 catalytic site [active] 234621005180 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 234621005181 intersubunit interface [polypeptide binding]; other site 234621005182 active site 234621005183 catalytic residue [active] 234621005184 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 234621005185 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 234621005186 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 234621005187 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 234621005188 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 234621005189 FAD binding domain; Region: FAD_binding_4; pfam01565 234621005190 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 234621005191 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 234621005192 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 234621005193 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 234621005194 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 234621005195 EspG family; Region: ESX-1_EspG; pfam14011 234621005196 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 234621005197 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621005198 NAD(P) binding site [chemical binding]; other site 234621005199 active site 234621005200 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 234621005201 Sulfatase; Region: Sulfatase; pfam00884 234621005202 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 234621005203 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 234621005204 active site 234621005205 iron coordination sites [ion binding]; other site 234621005206 substrate binding pocket [chemical binding]; other site 234621005207 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 234621005208 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 234621005209 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 234621005210 Transcriptional regulator [Transcription]; Region: LysR; COG0583 234621005211 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 234621005212 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 234621005213 putative dimerization interface [polypeptide binding]; other site 234621005214 Tocopherol cyclase; Region: Tocopherol_cycl; cl14571 234621005215 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 234621005216 CoenzymeA binding site [chemical binding]; other site 234621005217 subunit interaction site [polypeptide binding]; other site 234621005218 PHB binding site; other site 234621005219 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 234621005220 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 234621005221 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 234621005222 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 234621005223 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 234621005224 putative ADP-binding pocket [chemical binding]; other site 234621005225 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 234621005226 4-coumarate--CoA ligase; Region: PLN02246 234621005227 4-Coumarate-CoA Ligase (4CL); Region: 4CL; cd05904 234621005228 acyl-activating enzyme (AAE) consensus motif; other site 234621005229 active site 234621005230 putative CoA binding site [chemical binding]; other site 234621005231 AMP binding site [chemical binding]; other site 234621005232 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 234621005233 catalytic core [active] 234621005234 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 234621005235 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 234621005236 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234621005237 dimer interface [polypeptide binding]; other site 234621005238 phosphorylation site [posttranslational modification] 234621005239 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234621005240 ATP binding site [chemical binding]; other site 234621005241 Mg2+ binding site [ion binding]; other site 234621005242 G-X-G motif; other site 234621005243 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 234621005244 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234621005245 active site 234621005246 phosphorylation site [posttranslational modification] 234621005247 intermolecular recognition site; other site 234621005248 dimerization interface [polypeptide binding]; other site 234621005249 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 234621005250 DNA binding site [nucleotide binding] 234621005251 exopolyphosphatase; Region: exo_poly_only; TIGR03706 234621005252 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 234621005253 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 234621005254 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 234621005255 DNA interaction; other site 234621005256 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 234621005257 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 234621005258 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 234621005259 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 234621005260 putative acyl-acceptor binding pocket; other site 234621005261 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 234621005262 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 234621005263 putative acyl-acceptor binding pocket; other site 234621005264 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 234621005265 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 234621005266 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621005267 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621005268 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 234621005269 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 234621005270 DNA binding residues [nucleotide binding] 234621005271 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 234621005272 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 234621005273 active site 2 [active] 234621005274 active site 1 [active] 234621005275 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 234621005276 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 234621005277 DNA binding domain, excisionase family; Region: excise; TIGR01764 234621005278 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 234621005279 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 234621005280 putative NAD(P) binding site [chemical binding]; other site 234621005281 active site 234621005282 putative substrate binding site [chemical binding]; other site 234621005283 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 234621005284 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 234621005285 putative acyl-acceptor binding pocket; other site 234621005286 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 234621005287 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 234621005288 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 234621005289 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 234621005290 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 234621005291 CoA binding domain; Region: CoA_binding; smart00881 234621005292 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 234621005293 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 234621005294 tRNA; other site 234621005295 putative tRNA binding site [nucleotide binding]; other site 234621005296 putative NADP binding site [chemical binding]; other site 234621005297 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 234621005298 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 234621005299 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 234621005300 domain interfaces; other site 234621005301 active site 234621005302 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 234621005303 active site 234621005304 homodimer interface [polypeptide binding]; other site 234621005305 SAM binding site [chemical binding]; other site 234621005306 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 234621005307 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 234621005308 active site 234621005309 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 234621005310 dimer interface [polypeptide binding]; other site 234621005311 active site 234621005312 Schiff base residues; other site 234621005313 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 234621005314 putative homodimer interface [polypeptide binding]; other site 234621005315 putative homotetramer interface [polypeptide binding]; other site 234621005316 putative allosteric switch controlling residues; other site 234621005317 putative metal binding site [ion binding]; other site 234621005318 putative homodimer-homodimer interface [polypeptide binding]; other site 234621005319 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621005320 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621005321 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 234621005322 active site 234621005323 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 234621005324 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 234621005325 Active Sites [active] 234621005326 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 234621005327 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 234621005328 CysD dimerization site [polypeptide binding]; other site 234621005329 G1 box; other site 234621005330 putative GEF interaction site [polypeptide binding]; other site 234621005331 GTP/Mg2+ binding site [chemical binding]; other site 234621005332 Switch I region; other site 234621005333 G2 box; other site 234621005334 G3 box; other site 234621005335 Switch II region; other site 234621005336 G4 box; other site 234621005337 G5 box; other site 234621005338 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 234621005339 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 234621005340 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 234621005341 ligand-binding site [chemical binding]; other site 234621005342 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 234621005343 short chain dehydrogenase; Provisional; Region: PRK07890 234621005344 classical (c) SDRs; Region: SDR_c; cd05233 234621005345 NAD(P) binding site [chemical binding]; other site 234621005346 active site 234621005347 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 234621005348 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 234621005349 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 234621005350 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 234621005351 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 234621005352 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621005353 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621005354 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 234621005355 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 234621005356 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621005357 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621005358 active site 234621005359 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 234621005360 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 234621005361 inhibitor-cofactor binding pocket; inhibition site 234621005362 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234621005363 catalytic residue [active] 234621005364 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 234621005365 catalytic core [active] 234621005366 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 234621005367 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 234621005368 catalytic residues [active] 234621005369 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 234621005370 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 234621005371 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 234621005372 ResB-like family; Region: ResB; pfam05140 234621005373 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 234621005374 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 234621005375 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 234621005376 DNA binding residues [nucleotide binding] 234621005377 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 234621005378 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 234621005379 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 234621005380 catalytic residue [active] 234621005381 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 234621005382 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 234621005383 Coenzyme A binding pocket [chemical binding]; other site 234621005384 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 234621005385 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 234621005386 putative acyl-acceptor binding pocket; other site 234621005387 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 234621005388 Clp amino terminal domain; Region: Clp_N; pfam02861 234621005389 Predicted membrane protein [Function unknown]; Region: COG1950 234621005390 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 234621005391 UbiA prenyltransferase family; Region: UbiA; pfam01040 234621005392 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 234621005393 DNA binding site [nucleotide binding] 234621005394 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 234621005395 AAA ATPase domain; Region: AAA_16; pfam13191 234621005396 Predicted ATPase [General function prediction only]; Region: COG3903 234621005397 ABC-2 type transporter; Region: ABC2_membrane; cl17235 234621005398 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 234621005399 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234621005400 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 234621005401 Walker A/P-loop; other site 234621005402 ATP binding site [chemical binding]; other site 234621005403 Q-loop/lid; other site 234621005404 ABC transporter signature motif; other site 234621005405 Walker B; other site 234621005406 D-loop; other site 234621005407 H-loop/switch region; other site 234621005408 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 234621005409 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 234621005410 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 234621005411 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621005412 acyl-activating enzyme (AAE) consensus motif; other site 234621005413 AMP binding site [chemical binding]; other site 234621005414 active site 234621005415 CoA binding site [chemical binding]; other site 234621005416 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 234621005417 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 234621005418 Nucleopolyhedrovirus protein of unknown function (DUF912); Region: DUF912; pfam06024 234621005419 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 234621005420 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 234621005421 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 234621005422 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 234621005423 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 234621005424 TM-ABC transporter signature motif; other site 234621005425 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 234621005426 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 234621005427 TM-ABC transporter signature motif; other site 234621005428 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 234621005429 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 234621005430 Walker A/P-loop; other site 234621005431 ATP binding site [chemical binding]; other site 234621005432 Q-loop/lid; other site 234621005433 ABC transporter signature motif; other site 234621005434 Walker B; other site 234621005435 D-loop; other site 234621005436 H-loop/switch region; other site 234621005437 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 234621005438 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 234621005439 Walker A/P-loop; other site 234621005440 ATP binding site [chemical binding]; other site 234621005441 Q-loop/lid; other site 234621005442 ABC transporter signature motif; other site 234621005443 Walker B; other site 234621005444 D-loop; other site 234621005445 H-loop/switch region; other site 234621005446 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234621005447 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 234621005448 active site 234621005449 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 234621005450 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 234621005451 substrate binding site [chemical binding]; other site 234621005452 oxyanion hole (OAH) forming residues; other site 234621005453 trimer interface [polypeptide binding]; other site 234621005454 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 234621005455 CoenzymeA binding site [chemical binding]; other site 234621005456 subunit interaction site [polypeptide binding]; other site 234621005457 PHB binding site; other site 234621005458 O-succinylbenzoate synthase; Provisional; Region: PRK02901 234621005459 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 234621005460 active site 234621005461 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 234621005462 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 234621005463 FAD binding pocket [chemical binding]; other site 234621005464 FAD binding motif [chemical binding]; other site 234621005465 phosphate binding motif [ion binding]; other site 234621005466 NAD binding pocket [chemical binding]; other site 234621005467 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 234621005468 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 234621005469 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 234621005470 dimer interface [polypeptide binding]; other site 234621005471 tetramer interface [polypeptide binding]; other site 234621005472 PYR/PP interface [polypeptide binding]; other site 234621005473 TPP binding site [chemical binding]; other site 234621005474 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 234621005475 TPP-binding site; other site 234621005476 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 234621005477 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 234621005478 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 234621005479 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 234621005480 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234621005481 S-adenosylmethionine binding site [chemical binding]; other site 234621005482 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 234621005483 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 234621005484 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 234621005485 substrate binding pocket [chemical binding]; other site 234621005486 chain length determination region; other site 234621005487 substrate-Mg2+ binding site; other site 234621005488 catalytic residues [active] 234621005489 aspartate-rich region 1; other site 234621005490 active site lid residues [active] 234621005491 aspartate-rich region 2; other site 234621005492 heat shock protein HtpX; Provisional; Region: PRK03072 234621005493 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 234621005494 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 234621005495 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 234621005496 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 234621005497 active site 234621005498 catalytic site [active] 234621005499 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 234621005500 active site 234621005501 catalytic site [active] 234621005502 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 234621005503 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 234621005504 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 234621005505 putative homodimer interface [polypeptide binding]; other site 234621005506 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 234621005507 heterodimer interface [polypeptide binding]; other site 234621005508 homodimer interface [polypeptide binding]; other site 234621005509 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 234621005510 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 234621005511 23S rRNA interface [nucleotide binding]; other site 234621005512 L7/L12 interface [polypeptide binding]; other site 234621005513 putative thiostrepton binding site; other site 234621005514 L25 interface [polypeptide binding]; other site 234621005515 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 234621005516 mRNA/rRNA interface [nucleotide binding]; other site 234621005517 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 234621005518 23S rRNA interface [nucleotide binding]; other site 234621005519 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 234621005520 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 234621005521 core dimer interface [polypeptide binding]; other site 234621005522 peripheral dimer interface [polypeptide binding]; other site 234621005523 L10 interface [polypeptide binding]; other site 234621005524 L11 interface [polypeptide binding]; other site 234621005525 putative EF-Tu interaction site [polypeptide binding]; other site 234621005526 putative EF-G interaction site [polypeptide binding]; other site 234621005527 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 234621005528 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 234621005529 Walker A/P-loop; other site 234621005530 ATP binding site [chemical binding]; other site 234621005531 Q-loop/lid; other site 234621005532 ABC transporter signature motif; other site 234621005533 Walker B; other site 234621005534 D-loop; other site 234621005535 H-loop/switch region; other site 234621005536 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 234621005537 Permease; Region: Permease; pfam02405 234621005538 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 234621005539 Permease; Region: Permease; pfam02405 234621005540 mce related protein; Region: MCE; pfam02470 234621005541 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 234621005542 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 234621005543 mce related protein; Region: MCE; pfam02470 234621005544 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 234621005545 mce related protein; Region: MCE; pfam02470 234621005546 mce related protein; Region: MCE; pfam02470 234621005547 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 234621005548 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 234621005549 mce related protein; Region: MCE; pfam02470 234621005550 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 234621005551 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 234621005552 mce related protein; Region: MCE; pfam02470 234621005553 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 234621005554 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 234621005555 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 234621005556 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 234621005557 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 234621005558 RPB10 interaction site [polypeptide binding]; other site 234621005559 RPB1 interaction site [polypeptide binding]; other site 234621005560 RPB11 interaction site [polypeptide binding]; other site 234621005561 RPB3 interaction site [polypeptide binding]; other site 234621005562 RPB12 interaction site [polypeptide binding]; other site 234621005563 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 234621005564 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 234621005565 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 234621005566 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 234621005567 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 234621005568 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 234621005569 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 234621005570 G-loop; other site 234621005571 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 234621005572 DNA binding site [nucleotide binding] 234621005573 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 234621005574 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 234621005575 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234621005576 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 234621005577 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 234621005578 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 234621005579 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 234621005580 catalytic core [active] 234621005581 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 234621005582 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 234621005583 active site 2 [active] 234621005584 active site 1 [active] 234621005585 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 234621005586 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 234621005587 putative NAD(P) binding site [chemical binding]; other site 234621005588 tetracycline repressor protein TetR; Provisional; Region: PRK13756 234621005589 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621005590 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 234621005591 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 234621005592 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 234621005593 NAD(P) binding site [chemical binding]; other site 234621005594 Transcriptional regulators [Transcription]; Region: MarR; COG1846 234621005595 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 234621005596 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621005597 Major Facilitator Superfamily; Region: MFS_1; pfam07690 234621005598 putative substrate translocation pore; other site 234621005599 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621005600 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 234621005601 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 234621005602 Transcriptional regulators [Transcription]; Region: MarR; COG1846 234621005603 MarR family; Region: MarR_2; cl17246 234621005604 Pirin-related protein [General function prediction only]; Region: COG1741 234621005605 Pirin; Region: Pirin; pfam02678 234621005606 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 234621005607 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 234621005608 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 234621005609 trimer interface [polypeptide binding]; other site 234621005610 putative metal binding site [ion binding]; other site 234621005611 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 234621005612 enoyl-CoA hydratase; Provisional; Region: PRK09245 234621005613 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 234621005614 substrate binding site [chemical binding]; other site 234621005615 oxyanion hole (OAH) forming residues; other site 234621005616 trimer interface [polypeptide binding]; other site 234621005617 TIGR03084 family protein; Region: TIGR03084 234621005618 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 234621005619 Wyosine base formation; Region: Wyosine_form; pfam08608 234621005620 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 234621005621 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621005622 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621005623 active site 234621005624 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 234621005625 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 234621005626 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 234621005627 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 234621005628 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 234621005629 ATP-grasp domain; Region: ATP-grasp_4; cl17255 234621005630 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 234621005631 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 234621005632 carboxyltransferase (CT) interaction site; other site 234621005633 biotinylation site [posttranslational modification]; other site 234621005634 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621005635 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 234621005636 active site 234621005637 enoyl-CoA hydratase; Provisional; Region: PRK07827 234621005638 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 234621005639 substrate binding site [chemical binding]; other site 234621005640 oxyanion hole (OAH) forming residues; other site 234621005641 trimer interface [polypeptide binding]; other site 234621005642 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621005643 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621005644 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 234621005645 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 234621005646 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 234621005647 S17 interaction site [polypeptide binding]; other site 234621005648 S8 interaction site; other site 234621005649 16S rRNA interaction site [nucleotide binding]; other site 234621005650 streptomycin interaction site [chemical binding]; other site 234621005651 23S rRNA interaction site [nucleotide binding]; other site 234621005652 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 234621005653 30S ribosomal protein S7; Validated; Region: PRK05302 234621005654 elongation factor G; Reviewed; Region: PRK00007 234621005655 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 234621005656 G1 box; other site 234621005657 putative GEF interaction site [polypeptide binding]; other site 234621005658 GTP/Mg2+ binding site [chemical binding]; other site 234621005659 Switch I region; other site 234621005660 G2 box; other site 234621005661 G3 box; other site 234621005662 Switch II region; other site 234621005663 G4 box; other site 234621005664 G5 box; other site 234621005665 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 234621005666 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 234621005667 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 234621005668 elongation factor Tu; Reviewed; Region: PRK00049 234621005669 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 234621005670 G1 box; other site 234621005671 GEF interaction site [polypeptide binding]; other site 234621005672 GTP/Mg2+ binding site [chemical binding]; other site 234621005673 Switch I region; other site 234621005674 G2 box; other site 234621005675 G3 box; other site 234621005676 Switch II region; other site 234621005677 G4 box; other site 234621005678 G5 box; other site 234621005679 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 234621005680 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 234621005681 Antibiotic Binding Site [chemical binding]; other site 234621005682 Asp23 family; Region: Asp23; pfam03780 234621005683 Asp23 family; Region: Asp23; pfam03780 234621005684 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 234621005685 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 234621005686 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 234621005687 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 234621005688 A new structural DNA glycosylase; Region: AlkD_like; cd06561 234621005689 active site 234621005690 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 234621005691 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 234621005692 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 234621005693 FAD binding pocket [chemical binding]; other site 234621005694 FAD binding motif [chemical binding]; other site 234621005695 phosphate binding motif [ion binding]; other site 234621005696 beta-alpha-beta structure motif; other site 234621005697 NAD(p) ribose binding residues [chemical binding]; other site 234621005698 NAD binding pocket [chemical binding]; other site 234621005699 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 234621005700 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 234621005701 catalytic loop [active] 234621005702 iron binding site [ion binding]; other site 234621005703 NDMA-dependent methanol dehydrogenase; Region: NDMA_methanol; TIGR04266 234621005704 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 234621005705 active site 234621005706 NAD binding site [chemical binding]; other site 234621005707 metal binding site [ion binding]; metal-binding site 234621005708 MoxR-like ATPases [General function prediction only]; Region: COG0714 234621005709 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 234621005710 Walker A motif; other site 234621005711 ATP binding site [chemical binding]; other site 234621005712 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 234621005713 RNHCP domain; Region: RNHCP; pfam12647 234621005714 RNHCP domain; Region: RNHCP; pfam12647 234621005715 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH4; cd08188 234621005716 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 234621005717 putative active site [active] 234621005718 metal binding site [ion binding]; metal-binding site 234621005719 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 234621005720 Histidine kinase; Region: HisKA_3; pfam07730 234621005721 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 234621005722 ATP binding site [chemical binding]; other site 234621005723 Mg2+ binding site [ion binding]; other site 234621005724 G-X-G motif; other site 234621005725 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 234621005726 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234621005727 active site 234621005728 phosphorylation site [posttranslational modification] 234621005729 intermolecular recognition site; other site 234621005730 dimerization interface [polypeptide binding]; other site 234621005731 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 234621005732 DNA binding residues [nucleotide binding] 234621005733 dimerization interface [polypeptide binding]; other site 234621005734 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 234621005735 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 234621005736 DNA binding residues [nucleotide binding] 234621005737 MarR family; Region: MarR_2; pfam12802 234621005738 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 234621005739 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 234621005740 Walker A/P-loop; other site 234621005741 ATP binding site [chemical binding]; other site 234621005742 Q-loop/lid; other site 234621005743 ABC transporter signature motif; other site 234621005744 Walker B; other site 234621005745 D-loop; other site 234621005746 H-loop/switch region; other site 234621005747 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 234621005748 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 234621005749 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 234621005750 Protein of unknown function (DUF4059); Region: DUF4059; pfam13268 234621005751 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 234621005752 putative active site [active] 234621005753 putative catalytic site [active] 234621005754 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 234621005755 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 234621005756 Methyltransferase domain; Region: Methyltransf_23; pfam13489 234621005757 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234621005758 S-adenosylmethionine binding site [chemical binding]; other site 234621005759 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 234621005760 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621005761 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 234621005762 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 234621005763 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 234621005764 FeS/SAM binding site; other site 234621005765 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 234621005766 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 234621005767 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 234621005768 phosphate binding site [ion binding]; other site 234621005769 mycofactocin system FadH/OYE family oxidoreductase 1; Region: mycofact_OYE_1; TIGR03996 234621005770 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 234621005771 phosphate binding site [ion binding]; other site 234621005772 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 234621005773 classical (c) SDRs; Region: SDR_c; cd05233 234621005774 NAD(P) binding site [chemical binding]; other site 234621005775 active site 234621005776 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 234621005777 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 234621005778 putative active site [active] 234621005779 putative FMN binding site [chemical binding]; other site 234621005780 putative substrate binding site [chemical binding]; other site 234621005781 putative catalytic residue [active] 234621005782 Domain of unknown function (DUF222); Region: DUF222; pfam02720 234621005783 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 234621005784 active site 234621005785 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 234621005786 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 234621005787 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 234621005788 active site 234621005789 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 234621005790 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 234621005791 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 234621005792 DNA binding site [nucleotide binding] 234621005793 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 234621005794 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 234621005795 NAD(P) binding site [chemical binding]; other site 234621005796 catalytic residues [active] 234621005797 Protein of unknown function (DUF779); Region: DUF779; pfam05610 234621005798 ethanolamine permease; Region: 2A0305; TIGR00908 234621005799 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 234621005800 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 234621005801 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 234621005802 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 234621005803 metabolite-proton symporter; Region: 2A0106; TIGR00883 234621005804 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621005805 putative substrate translocation pore; other site 234621005806 AMP-binding domain protein; Validated; Region: PRK08315 234621005807 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621005808 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 234621005809 acyl-activating enzyme (AAE) consensus motif; other site 234621005810 putative AMP binding site [chemical binding]; other site 234621005811 putative active site [active] 234621005812 putative CoA binding site [chemical binding]; other site 234621005813 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 234621005814 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 234621005815 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 234621005816 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 234621005817 NAD(P) binding site [chemical binding]; other site 234621005818 catalytic residues [active] 234621005819 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 234621005820 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 234621005821 NAD binding site [chemical binding]; other site 234621005822 catalytic Zn binding site [ion binding]; other site 234621005823 substrate binding site [chemical binding]; other site 234621005824 structural Zn binding site [ion binding]; other site 234621005825 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 234621005826 metal binding site [ion binding]; metal-binding site 234621005827 MMPL family; Region: MMPL; pfam03176 234621005828 MMPL family; Region: MMPL; pfam03176 234621005829 PQQ-like domain; Region: PQQ_2; pfam13360 234621005830 PQQ-like domain; Region: PQQ_2; pfam13360 234621005831 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 234621005832 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 234621005833 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 234621005834 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 234621005835 synthetase active site [active] 234621005836 NTP binding site [chemical binding]; other site 234621005837 metal binding site [ion binding]; metal-binding site 234621005838 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621005839 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621005840 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 234621005841 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 234621005842 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 234621005843 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 234621005844 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 234621005845 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 234621005846 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 234621005847 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 234621005848 carboxyltransferase (CT) interaction site; other site 234621005849 biotinylation site [posttranslational modification]; other site 234621005850 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621005851 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621005852 active site 234621005853 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 234621005854 putative active site [active] 234621005855 putative catalytic site [active] 234621005856 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 234621005857 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 234621005858 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 234621005859 Condensation domain; Region: Condensation; pfam00668 234621005860 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 234621005861 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 234621005862 acyl-activating enzyme (AAE) consensus motif; other site 234621005863 AMP binding site [chemical binding]; other site 234621005864 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 234621005865 Condensation domain; Region: Condensation; pfam00668 234621005866 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 234621005867 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 234621005868 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 234621005869 acyl-activating enzyme (AAE) consensus motif; other site 234621005870 AMP binding site [chemical binding]; other site 234621005871 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 234621005872 Condensation domain; Region: Condensation; pfam00668 234621005873 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 234621005874 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 234621005875 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 234621005876 acyl-activating enzyme (AAE) consensus motif; other site 234621005877 AMP binding site [chemical binding]; other site 234621005878 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 234621005879 Condensation domain; Region: Condensation; pfam00668 234621005880 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 234621005881 peptide synthase; Validated; Region: PRK05691 234621005882 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 234621005883 acyl-activating enzyme (AAE) consensus motif; other site 234621005884 AMP binding site [chemical binding]; other site 234621005885 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 234621005886 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 234621005887 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 234621005888 acyl-activating enzyme (AAE) consensus motif; other site 234621005889 AMP binding site [chemical binding]; other site 234621005890 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 234621005891 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 234621005892 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 234621005893 acyl-activating enzyme (AAE) consensus motif; other site 234621005894 AMP binding site [chemical binding]; other site 234621005895 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 234621005896 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 234621005897 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 234621005898 acyl-activating enzyme (AAE) consensus motif; other site 234621005899 AMP binding site [chemical binding]; other site 234621005900 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 234621005901 Condensation domain; Region: Condensation; pfam00668 234621005902 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 234621005903 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 234621005904 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 234621005905 acyl-activating enzyme (AAE) consensus motif; other site 234621005906 AMP binding site [chemical binding]; other site 234621005907 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 234621005908 Condensation domain; Region: Condensation; pfam00668 234621005909 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 234621005910 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 234621005911 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 234621005912 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 234621005913 acyl-activating enzyme (AAE) consensus motif; other site 234621005914 AMP binding site [chemical binding]; other site 234621005915 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 234621005916 Condensation domain; Region: Condensation; pfam00668 234621005917 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 234621005918 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 234621005919 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 234621005920 acyl-activating enzyme (AAE) consensus motif; other site 234621005921 AMP binding site [chemical binding]; other site 234621005922 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 234621005923 Condensation domain; Region: Condensation; pfam00668 234621005924 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 234621005925 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 234621005926 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 234621005927 acyl-activating enzyme (AAE) consensus motif; other site 234621005928 AMP binding site [chemical binding]; other site 234621005929 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 234621005930 Condensation domain; Region: Condensation; pfam00668 234621005931 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 234621005932 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 234621005933 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 234621005934 acyl-activating enzyme (AAE) consensus motif; other site 234621005935 AMP binding site [chemical binding]; other site 234621005936 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 234621005937 Condensation domain; Region: Condensation; pfam00668 234621005938 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 234621005939 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 234621005940 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621005941 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 234621005942 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 234621005943 acyl-activating enzyme (AAE) consensus motif; other site 234621005944 AMP binding site [chemical binding]; other site 234621005945 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 234621005946 Condensation domain; Region: Condensation; pfam00668 234621005947 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 234621005948 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 234621005949 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 234621005950 acyl-activating enzyme (AAE) consensus motif; other site 234621005951 AMP binding site [chemical binding]; other site 234621005952 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 234621005953 Condensation domain; Region: Condensation; pfam00668 234621005954 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 234621005955 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 234621005956 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 234621005957 acyl-activating enzyme (AAE) consensus motif; other site 234621005958 AMP binding site [chemical binding]; other site 234621005959 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 234621005960 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 234621005961 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 234621005962 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 234621005963 acyl-activating enzyme (AAE) consensus motif; other site 234621005964 AMP binding site [chemical binding]; other site 234621005965 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 234621005966 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 234621005967 Lipase (class 2); Region: Lipase_2; pfam01674 234621005968 Putative esterase; Region: Esterase; pfam00756 234621005969 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 234621005970 ABC-2 type transporter; Region: ABC2_membrane; cl17235 234621005971 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 234621005972 ABC-2 type transporter; Region: ABC2_membrane; cl17235 234621005973 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234621005974 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 234621005975 Walker A/P-loop; other site 234621005976 ATP binding site [chemical binding]; other site 234621005977 Q-loop/lid; other site 234621005978 ABC transporter signature motif; other site 234621005979 Walker B; other site 234621005980 D-loop; other site 234621005981 H-loop/switch region; other site 234621005982 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 234621005983 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 234621005984 active site 234621005985 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 234621005986 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 234621005987 prephenate dehydrogenase; Provisional; Region: PRK08655 234621005988 arogenate dehydrogenase; Region: PLN02256 234621005989 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 234621005990 Glutamine amidotransferase class-I; Region: GATase; pfam00117 234621005991 glutamine binding [chemical binding]; other site 234621005992 catalytic triad [active] 234621005993 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 234621005994 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 234621005995 chorismate binding enzyme; Region: Chorismate_bind; cl10555 234621005996 Chorismate mutase type II; Region: CM_2; cl00693 234621005997 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 234621005998 CoenzymeA binding site [chemical binding]; other site 234621005999 subunit interaction site [polypeptide binding]; other site 234621006000 PHB binding site; other site 234621006001 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 234621006002 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 234621006003 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 234621006004 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 234621006005 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 234621006006 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 234621006007 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 234621006008 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 234621006009 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 234621006010 putative translocon binding site; other site 234621006011 protein-rRNA interface [nucleotide binding]; other site 234621006012 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 234621006013 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 234621006014 G-X-X-G motif; other site 234621006015 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 234621006016 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 234621006017 23S rRNA interface [nucleotide binding]; other site 234621006018 5S rRNA interface [nucleotide binding]; other site 234621006019 putative antibiotic binding site [chemical binding]; other site 234621006020 L25 interface [polypeptide binding]; other site 234621006021 L27 interface [polypeptide binding]; other site 234621006022 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 234621006023 23S rRNA interface [nucleotide binding]; other site 234621006024 putative translocon interaction site; other site 234621006025 signal recognition particle (SRP54) interaction site; other site 234621006026 L23 interface [polypeptide binding]; other site 234621006027 trigger factor interaction site; other site 234621006028 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 234621006029 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 234621006030 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 234621006031 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 234621006032 RNA binding site [nucleotide binding]; other site 234621006033 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 234621006034 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 234621006035 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 234621006036 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 234621006037 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 234621006038 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 234621006039 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 234621006040 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 234621006041 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 234621006042 5S rRNA interface [nucleotide binding]; other site 234621006043 L27 interface [polypeptide binding]; other site 234621006044 23S rRNA interface [nucleotide binding]; other site 234621006045 L5 interface [polypeptide binding]; other site 234621006046 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 234621006047 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 234621006048 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 234621006049 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 234621006050 23S rRNA binding site [nucleotide binding]; other site 234621006051 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 234621006052 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 234621006053 SecY translocase; Region: SecY; pfam00344 234621006054 adenylate kinase; Reviewed; Region: adk; PRK00279 234621006055 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 234621006056 AMP-binding site [chemical binding]; other site 234621006057 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 234621006058 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 234621006059 active site 234621006060 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 234621006061 rRNA binding site [nucleotide binding]; other site 234621006062 predicted 30S ribosome binding site; other site 234621006063 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 234621006064 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 234621006065 30S ribosomal protein S13; Region: bact_S13; TIGR03631 234621006066 30S ribosomal protein S11; Validated; Region: PRK05309 234621006067 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 234621006068 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 234621006069 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 234621006070 RNA binding surface [nucleotide binding]; other site 234621006071 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 234621006072 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 234621006073 alphaNTD - beta interaction site [polypeptide binding]; other site 234621006074 alphaNTD homodimer interface [polypeptide binding]; other site 234621006075 alphaNTD - beta' interaction site [polypeptide binding]; other site 234621006076 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 234621006077 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 234621006078 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 234621006079 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 234621006080 dimerization interface 3.5A [polypeptide binding]; other site 234621006081 active site 234621006082 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621006083 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621006084 active site 234621006085 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621006086 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621006087 Predicted flavoprotein [General function prediction only]; Region: COG0431 234621006088 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 234621006089 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 234621006090 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919 234621006091 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 234621006092 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 234621006093 active site 234621006094 catalytic residues [active] 234621006095 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 234621006096 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 234621006097 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 234621006098 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 234621006099 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 234621006100 catalytic residues [active] 234621006101 catalytic nucleophile [active] 234621006102 Recombinase; Region: Recombinase; pfam07508 234621006103 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 234621006104 Helix-turn-helix domain; Region: HTH_17; cl17695 234621006105 Phage-related protein [Function unknown]; Region: COG4695; cl01923 234621006106 Phage portal protein; Region: Phage_portal; pfam04860 234621006107 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 234621006108 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 234621006109 Phage capsid family; Region: Phage_capsid; pfam05065 234621006110 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 234621006111 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 234621006112 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 234621006113 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 234621006114 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 234621006115 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 234621006116 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 234621006117 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 234621006118 23S rRNA interface [nucleotide binding]; other site 234621006119 L3 interface [polypeptide binding]; other site 234621006120 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 234621006121 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 234621006122 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 234621006123 active site 234621006124 substrate binding site [chemical binding]; other site 234621006125 metal binding site [ion binding]; metal-binding site 234621006126 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 234621006127 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 234621006128 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 234621006129 glutaminase active site [active] 234621006130 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 234621006131 dimer interface [polypeptide binding]; other site 234621006132 active site 234621006133 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 234621006134 dimer interface [polypeptide binding]; other site 234621006135 active site 234621006136 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 234621006137 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 234621006138 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 234621006139 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 234621006140 putative substrate binding site [chemical binding]; other site 234621006141 putative ATP binding site [chemical binding]; other site 234621006142 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 234621006143 alanine racemase; Reviewed; Region: alr; PRK00053 234621006144 active site 234621006145 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 234621006146 dimer interface [polypeptide binding]; other site 234621006147 substrate binding site [chemical binding]; other site 234621006148 catalytic residues [active] 234621006149 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 234621006150 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 234621006151 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 234621006152 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 234621006153 Glycoprotease family; Region: Peptidase_M22; pfam00814 234621006154 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 234621006155 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 234621006156 UGMP family protein; Validated; Region: PRK09604 234621006157 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 234621006158 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 234621006159 nucleotide binding site [chemical binding]; other site 234621006160 Ion channel; Region: Ion_trans_2; pfam07885 234621006161 metallophosphoesterase, PPA1498 family; Region: P_acnes_RR; TIGR03767 234621006162 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 234621006163 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 234621006164 oligomerisation interface [polypeptide binding]; other site 234621006165 mobile loop; other site 234621006166 roof hairpin; other site 234621006167 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 234621006168 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 234621006169 ring oligomerisation interface [polypeptide binding]; other site 234621006170 ATP/Mg binding site [chemical binding]; other site 234621006171 stacking interactions; other site 234621006172 hinge regions; other site 234621006173 Anti-sigma-K factor rskA; Region: RskA; pfam10099 234621006174 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 234621006175 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234621006176 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234621006177 DNA binding residues [nucleotide binding] 234621006178 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 234621006179 Fasciclin domain; Region: Fasciclin; pfam02469 234621006180 Transcription factor WhiB; Region: Whib; pfam02467 234621006181 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 234621006182 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234621006183 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234621006184 DNA binding residues [nucleotide binding] 234621006185 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 234621006186 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 234621006187 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 234621006188 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 234621006189 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 234621006190 active site 234621006191 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 234621006192 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 234621006193 active site 234621006194 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 234621006195 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 234621006196 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 234621006197 GMP synthase; Reviewed; Region: guaA; PRK00074 234621006198 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 234621006199 AMP/PPi binding site [chemical binding]; other site 234621006200 candidate oxyanion hole; other site 234621006201 catalytic triad [active] 234621006202 potential glutamine specificity residues [chemical binding]; other site 234621006203 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 234621006204 ATP Binding subdomain [chemical binding]; other site 234621006205 Ligand Binding sites [chemical binding]; other site 234621006206 Dimerization subdomain; other site 234621006207 PspC domain; Region: PspC; pfam04024 234621006208 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 234621006209 PspC domain; Region: PspC; pfam04024 234621006210 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 234621006211 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 234621006212 Mg2+ binding site [ion binding]; other site 234621006213 G-X-G motif; other site 234621006214 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 234621006215 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234621006216 active site 234621006217 phosphorylation site [posttranslational modification] 234621006218 intermolecular recognition site; other site 234621006219 dimerization interface [polypeptide binding]; other site 234621006220 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 234621006221 DNA binding residues [nucleotide binding] 234621006222 dimerization interface [polypeptide binding]; other site 234621006223 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621006224 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 234621006225 putative substrate translocation pore; other site 234621006226 Major Facilitator Superfamily; Region: MFS_1; pfam07690 234621006227 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621006228 putative substrate translocation pore; other site 234621006229 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 234621006230 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 234621006231 dimerization interface [polypeptide binding]; other site 234621006232 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234621006233 dimer interface [polypeptide binding]; other site 234621006234 phosphorylation site [posttranslational modification] 234621006235 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234621006236 ATP binding site [chemical binding]; other site 234621006237 Mg2+ binding site [ion binding]; other site 234621006238 G-X-G motif; other site 234621006239 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 234621006240 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234621006241 active site 234621006242 phosphorylation site [posttranslational modification] 234621006243 intermolecular recognition site; other site 234621006244 dimerization interface [polypeptide binding]; other site 234621006245 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 234621006246 DNA binding site [nucleotide binding] 234621006247 PAP2 superfamily; Region: PAP2; pfam01569 234621006248 active site 234621006249 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 234621006250 Predicted transcriptional regulators [Transcription]; Region: COG1733 234621006251 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 234621006252 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234621006253 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 234621006254 FAD binding domain; Region: FAD_binding_4; pfam01565 234621006255 Berberine and berberine like; Region: BBE; pfam08031 234621006256 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234621006257 Catalytic domain of Protein Kinases; Region: PKc; cd00180 234621006258 active site 234621006259 ATP binding site [chemical binding]; other site 234621006260 substrate binding site [chemical binding]; other site 234621006261 activation loop (A-loop); other site 234621006262 DNA Polymerase Y-family; Region: PolY_like; cd03468 234621006263 active site 234621006264 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 234621006265 DNA binding site [nucleotide binding] 234621006266 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 234621006267 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 234621006268 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 234621006269 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 234621006270 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 234621006271 Sulfatase; Region: Sulfatase; pfam00884 234621006272 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 234621006273 active site 234621006274 diiron metal binding site [ion binding]; other site 234621006275 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 234621006276 Zn2+ binding site [ion binding]; other site 234621006277 Mg2+ binding site [ion binding]; other site 234621006278 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 234621006279 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 234621006280 conserved cys residue [active] 234621006281 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 234621006282 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 234621006283 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 234621006284 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 234621006285 catalytic site [active] 234621006286 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 234621006287 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 234621006288 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 234621006289 putative dimer interface [polypeptide binding]; other site 234621006290 putative [2Fe-2S] cluster binding site [ion binding]; other site 234621006291 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 234621006292 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 234621006293 Coenzyme A binding pocket [chemical binding]; other site 234621006294 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 234621006295 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 234621006296 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621006297 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621006298 Transcriptional regulator [Transcription]; Region: LysR; COG0583 234621006299 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 234621006300 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 234621006301 putative dimerization interface [polypeptide binding]; other site 234621006302 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 234621006303 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 234621006304 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 234621006305 catalytic residue [active] 234621006306 short chain dehydrogenase; Provisional; Region: PRK07201 234621006307 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 234621006308 putative NAD(P) binding site [chemical binding]; other site 234621006309 active site 234621006310 putative substrate binding site [chemical binding]; other site 234621006311 classical (c) SDRs; Region: SDR_c; cd05233 234621006312 NAD(P) binding site [chemical binding]; other site 234621006313 active site 234621006314 MMPL family; Region: MMPL; pfam03176 234621006315 MMPL family; Region: MMPL; pfam03176 234621006316 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 234621006317 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 234621006318 intersubunit interface [polypeptide binding]; other site 234621006319 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 234621006320 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 234621006321 ABC-ATPase subunit interface; other site 234621006322 dimer interface [polypeptide binding]; other site 234621006323 putative PBP binding regions; other site 234621006324 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 234621006325 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 234621006326 Walker A/P-loop; other site 234621006327 ATP binding site [chemical binding]; other site 234621006328 Q-loop/lid; other site 234621006329 ABC transporter signature motif; other site 234621006330 Walker B; other site 234621006331 D-loop; other site 234621006332 H-loop/switch region; other site 234621006333 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 234621006334 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 234621006335 alkaline phosphatase; Provisional; Region: PRK10518 234621006336 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 234621006337 dimer interface [polypeptide binding]; other site 234621006338 active site 234621006339 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 234621006340 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 234621006341 active site 234621006342 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 234621006343 generic binding surface II; other site 234621006344 generic binding surface I; other site 234621006345 short chain dehydrogenase; Provisional; Region: PRK07063 234621006346 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621006347 NAD(P) binding site [chemical binding]; other site 234621006348 active site 234621006349 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 234621006350 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 234621006351 putative NAD(P) binding site [chemical binding]; other site 234621006352 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 234621006353 CAAX protease self-immunity; Region: Abi; pfam02517 234621006354 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 234621006355 active site residue [active] 234621006356 RibD C-terminal domain; Region: RibD_C; cl17279 234621006357 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 234621006358 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 234621006359 gating phenylalanine in ion channel; other site 234621006360 Transcriptional regulator [Transcription]; Region: LysR; COG0583 234621006361 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 234621006362 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 234621006363 putative dimerization interface [polypeptide binding]; other site 234621006364 tetracycline repressor protein TetR; Provisional; Region: PRK13756 234621006365 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621006366 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 234621006367 hypothetical protein; Provisional; Region: PRK07236 234621006368 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 234621006369 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 234621006370 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 234621006371 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 234621006372 [4Fe-4S] binding site [ion binding]; other site 234621006373 molybdopterin cofactor binding site; other site 234621006374 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 234621006375 molybdopterin cofactor binding site; other site 234621006376 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 234621006377 Flavodoxin; Region: Flavodoxin_1; pfam00258 234621006378 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 234621006379 FAD binding pocket [chemical binding]; other site 234621006380 FAD binding motif [chemical binding]; other site 234621006381 catalytic residues [active] 234621006382 NAD binding pocket [chemical binding]; other site 234621006383 phosphate binding motif [ion binding]; other site 234621006384 beta-alpha-beta structure motif; other site 234621006385 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 234621006386 Excalibur calcium-binding domain; Region: Excalibur; smart00894 234621006387 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 234621006388 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 234621006389 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 234621006390 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 234621006391 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 234621006392 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 234621006393 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 234621006394 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 234621006395 homodimer interface [polypeptide binding]; other site 234621006396 NADP binding site [chemical binding]; other site 234621006397 substrate binding site [chemical binding]; other site 234621006398 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 234621006399 Uncharacterized conserved protein [Function unknown]; Region: COG4279 234621006400 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 234621006401 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 234621006402 ATP binding site [chemical binding]; other site 234621006403 putative Mg++ binding site [ion binding]; other site 234621006404 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 234621006405 nucleotide binding region [chemical binding]; other site 234621006406 ATP-binding site [chemical binding]; other site 234621006407 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 234621006408 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 234621006409 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 234621006410 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 234621006411 homodimer interface [polypeptide binding]; other site 234621006412 substrate-cofactor binding pocket; other site 234621006413 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234621006414 catalytic residue [active] 234621006415 isocitrate dehydrogenase; Validated; Region: PRK08299 234621006416 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621006417 Major Facilitator Superfamily; Region: MFS_1; pfam07690 234621006418 putative substrate translocation pore; other site 234621006419 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 234621006420 putative active site [active] 234621006421 putative catalytic site [active] 234621006422 putative DNA binding site [nucleotide binding]; other site 234621006423 putative phosphate binding site [ion binding]; other site 234621006424 metal binding site A [ion binding]; metal-binding site 234621006425 putative AP binding site [nucleotide binding]; other site 234621006426 putative metal binding site B [ion binding]; other site 234621006427 ribonuclease; Region: Ribonuclease; pfam00545 234621006428 active site 234621006429 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 234621006430 putative RNAase interaction site [polypeptide binding]; other site 234621006431 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 234621006432 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 234621006433 active site 234621006434 HIGH motif; other site 234621006435 dimer interface [polypeptide binding]; other site 234621006436 KMSKS motif; other site 234621006437 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 234621006438 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 234621006439 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 234621006440 RibD C-terminal domain; Region: RibD_C; cl17279 234621006441 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 234621006442 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 234621006443 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 234621006444 tetrameric interface [polypeptide binding]; other site 234621006445 NAD binding site [chemical binding]; other site 234621006446 catalytic residues [active] 234621006447 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 234621006448 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234621006449 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234621006450 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 234621006451 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 234621006452 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 234621006453 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 234621006454 PYR/PP interface [polypeptide binding]; other site 234621006455 dimer interface [polypeptide binding]; other site 234621006456 TPP binding site [chemical binding]; other site 234621006457 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 234621006458 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 234621006459 TPP-binding site; other site 234621006460 KduI/IolB family; Region: KduI; pfam04962 234621006461 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 234621006462 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 234621006463 substrate binding site [chemical binding]; other site 234621006464 ATP binding site [chemical binding]; other site 234621006465 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 234621006466 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 234621006467 DNA-binding site [nucleotide binding]; DNA binding site 234621006468 UTRA domain; Region: UTRA; pfam07702 234621006469 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234621006470 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234621006471 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 234621006472 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621006473 Major Facilitator Superfamily; Region: MFS_1; pfam07690 234621006474 putative substrate translocation pore; other site 234621006475 hypothetical protein; Provisional; Region: PRK06834 234621006476 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 234621006477 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 234621006478 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 234621006479 active site 234621006480 catalytic residues [active] 234621006481 metal binding site [ion binding]; metal-binding site 234621006482 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 234621006483 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234621006484 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234621006485 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 234621006486 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234621006487 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234621006488 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 234621006489 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 234621006490 DNA interaction; other site 234621006491 Metal-binding active site; metal-binding site 234621006492 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234621006493 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234621006494 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 234621006495 Transcriptional regulators [Transcription]; Region: PurR; COG1609 234621006496 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 234621006497 DNA binding site [nucleotide binding] 234621006498 domain linker motif; other site 234621006499 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 234621006500 ligand binding site [chemical binding]; other site 234621006501 dimerization interface [polypeptide binding]; other site 234621006502 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 234621006503 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 234621006504 putative ligand binding site [chemical binding]; other site 234621006505 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 234621006506 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 234621006507 TM-ABC transporter signature motif; other site 234621006508 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 234621006509 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 234621006510 Walker A/P-loop; other site 234621006511 ATP binding site [chemical binding]; other site 234621006512 Q-loop/lid; other site 234621006513 ABC transporter signature motif; other site 234621006514 Walker B; other site 234621006515 D-loop; other site 234621006516 H-loop/switch region; other site 234621006517 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234621006518 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234621006519 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 234621006520 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 234621006521 Metal-binding active site; metal-binding site 234621006522 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234621006523 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234621006524 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 234621006525 short chain dehydrogenase; Provisional; Region: PRK06198 234621006526 classical (c) SDRs; Region: SDR_c; cd05233 234621006527 NAD(P) binding site [chemical binding]; other site 234621006528 active site 234621006529 Transcriptional regulators [Transcription]; Region: PurR; COG1609 234621006530 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 234621006531 DNA binding site [nucleotide binding] 234621006532 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 234621006533 putative ligand binding site [chemical binding]; other site 234621006534 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 234621006535 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 234621006536 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 234621006537 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 234621006538 L-aspartate oxidase; Provisional; Region: PRK06175 234621006539 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 234621006540 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 234621006541 putative Iron-sulfur protein interface [polypeptide binding]; other site 234621006542 putative proximal heme binding site [chemical binding]; other site 234621006543 putative SdhC-like subunit interface [polypeptide binding]; other site 234621006544 putative distal heme binding site [chemical binding]; other site 234621006545 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 234621006546 putative Iron-sulfur protein interface [polypeptide binding]; other site 234621006547 putative proximal heme binding site [chemical binding]; other site 234621006548 putative SdhD-like interface [polypeptide binding]; other site 234621006549 putative distal heme binding site [chemical binding]; other site 234621006550 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 234621006551 active site 234621006552 catalytic motif [active] 234621006553 Zn binding site [ion binding]; other site 234621006554 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 234621006555 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 234621006556 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 234621006557 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 234621006558 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 234621006559 adenosine deaminase; Provisional; Region: PRK09358 234621006560 active site 234621006561 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 234621006562 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 234621006563 catalytic residues [active] 234621006564 catalytic nucleophile [active] 234621006565 Recombinase; Region: Recombinase; pfam07508 234621006566 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 234621006567 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 234621006568 active site 234621006569 metal binding site [ion binding]; metal-binding site 234621006570 interdomain interaction site; other site 234621006571 AAA domain; Region: AAA_25; pfam13481 234621006572 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 234621006573 Walker A motif; other site 234621006574 ATP binding site [chemical binding]; other site 234621006575 Walker B motif; other site 234621006576 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 234621006577 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 234621006578 tape measure domain; Region: tape_meas_nterm; TIGR02675 234621006579 NlpC/P60 family; Region: NLPC_P60; cl17555 234621006580 transposase/IS protein; Provisional; Region: PRK09183 234621006581 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234621006582 Walker A motif; other site 234621006583 ATP binding site [chemical binding]; other site 234621006584 Walker B motif; other site 234621006585 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 234621006586 Integrase core domain; Region: rve; pfam00665 234621006587 Helix-turn-helix domain; Region: HTH_17; pfam12728 234621006588 Helix-turn-helix domain; Region: HTH_17; pfam12728 234621006589 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 234621006590 NlpC/P60 family; Region: NLPC_P60; pfam00877 234621006591 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 234621006592 active site 234621006593 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 234621006594 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 234621006595 active site 234621006596 substrate binding site [chemical binding]; other site 234621006597 metal binding site [ion binding]; metal-binding site 234621006598 purine nucleoside phosphorylase; Provisional; Region: PRK08202 234621006599 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 234621006600 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 234621006601 substrate binding site [chemical binding]; other site 234621006602 oxyanion hole (OAH) forming residues; other site 234621006603 trimer interface [polypeptide binding]; other site 234621006604 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 234621006605 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 234621006606 metal binding site [ion binding]; metal-binding site 234621006607 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 234621006608 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 234621006609 metal binding site [ion binding]; metal-binding site 234621006610 putative dimer interface [polypeptide binding]; other site 234621006611 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 234621006612 putative active site pocket [active] 234621006613 dimerization interface [polypeptide binding]; other site 234621006614 putative catalytic residue [active] 234621006615 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 234621006616 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 234621006617 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 234621006618 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 234621006619 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 234621006620 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 234621006621 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234621006622 homodimer interface [polypeptide binding]; other site 234621006623 catalytic residue [active] 234621006624 Coenzyme A transferase; Region: CoA_trans; cl17247 234621006625 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 234621006626 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 234621006627 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 234621006628 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 234621006629 dimerization interface [polypeptide binding]; other site 234621006630 substrate binding pocket [chemical binding]; other site 234621006631 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621006632 metabolite-proton symporter; Region: 2A0106; TIGR00883 234621006633 putative substrate translocation pore; other site 234621006634 glycerol kinase; Provisional; Region: glpK; PRK00047 234621006635 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 234621006636 N- and C-terminal domain interface [polypeptide binding]; other site 234621006637 active site 234621006638 MgATP binding site [chemical binding]; other site 234621006639 catalytic site [active] 234621006640 metal binding site [ion binding]; metal-binding site 234621006641 putative homotetramer interface [polypeptide binding]; other site 234621006642 glycerol binding site [chemical binding]; other site 234621006643 homodimer interface [polypeptide binding]; other site 234621006644 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 234621006645 GAF domain; Region: GAF_2; pfam13185 234621006646 ANTAR domain; Region: ANTAR; pfam03861 234621006647 Transcriptional regulator [Transcription]; Region: LysR; COG0583 234621006648 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 234621006649 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 234621006650 dimerization interface [polypeptide binding]; other site 234621006651 metabolite-proton symporter; Region: 2A0106; TIGR00883 234621006652 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621006653 putative substrate translocation pore; other site 234621006654 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 234621006655 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621006656 NAD(P) binding site [chemical binding]; other site 234621006657 active site 234621006658 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 234621006659 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 234621006660 active site 234621006661 catalytic tetrad [active] 234621006662 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 234621006663 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 234621006664 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 234621006665 putative DNA binding site [nucleotide binding]; other site 234621006666 catalytic residue [active] 234621006667 putative H2TH interface [polypeptide binding]; other site 234621006668 putative catalytic residues [active] 234621006669 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 234621006670 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 234621006671 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 234621006672 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 234621006673 ATP binding site [chemical binding]; other site 234621006674 putative Mg++ binding site [ion binding]; other site 234621006675 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 234621006676 nucleotide binding region [chemical binding]; other site 234621006677 ATP-binding site [chemical binding]; other site 234621006678 DEAD/H associated; Region: DEAD_assoc; pfam08494 234621006679 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 234621006680 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 234621006681 N-formylglutamate amidohydrolase; Region: FGase; cl01522 234621006682 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621006683 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 234621006684 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621006685 active site 234621006686 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 234621006687 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234621006688 non-specific DNA binding site [nucleotide binding]; other site 234621006689 salt bridge; other site 234621006690 sequence-specific DNA binding site [nucleotide binding]; other site 234621006691 xanthine permease; Region: pbuX; TIGR03173 234621006692 oxidoreductase; Region: PLN02485 234621006693 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 234621006694 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 234621006695 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 234621006696 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 234621006697 aldehyde dehydrogenase family 7 member; Region: PLN02315 234621006698 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 234621006699 tetrameric interface [polypeptide binding]; other site 234621006700 NAD binding site [chemical binding]; other site 234621006701 catalytic residues [active] 234621006702 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 234621006703 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 234621006704 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 234621006705 AsnC family; Region: AsnC_trans_reg; pfam01037 234621006706 L-lysine aminotransferase; Provisional; Region: PRK08297 234621006707 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 234621006708 inhibitor-cofactor binding pocket; inhibition site 234621006709 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234621006710 catalytic residue [active] 234621006711 putative hypoxanthine oxidase; Provisional; Region: PRK09800 234621006712 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 234621006713 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 234621006714 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 234621006715 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 234621006716 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 234621006717 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 234621006718 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 234621006719 active site 234621006720 putative substrate binding pocket [chemical binding]; other site 234621006721 urate oxidase; Region: urate_oxi; TIGR03383 234621006722 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 234621006723 active site 234621006724 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 234621006725 active site 234621006726 homotetramer interface [polypeptide binding]; other site 234621006727 putative OHCU decarboxylase; Provisional; Region: PRK13798 234621006728 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 234621006729 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 234621006730 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 234621006731 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 234621006732 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 234621006733 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 234621006734 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 234621006735 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 234621006736 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 234621006737 carboxyltransferase (CT) interaction site; other site 234621006738 biotinylation site [posttranslational modification]; other site 234621006739 Condensation domain; Region: Condensation; pfam00668 234621006740 Fe-S metabolism associated domain; Region: SufE; cl00951 234621006741 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 234621006742 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 234621006743 active site residue [active] 234621006744 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 234621006745 active site residue [active] 234621006746 peptide synthase; Provisional; Region: PRK12316 234621006747 Condensation domain; Region: Condensation; pfam00668 234621006748 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621006749 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 234621006750 putative substrate translocation pore; other site 234621006751 Domain of unknown function (DUF222); Region: DUF222; pfam02720 234621006752 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 234621006753 active site 234621006754 Maf-like protein; Region: Maf; pfam02545 234621006755 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 234621006756 active site 234621006757 dimer interface [polypeptide binding]; other site 234621006758 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 234621006759 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 234621006760 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 234621006761 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 234621006762 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 234621006763 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 234621006764 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 234621006765 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 234621006766 Bacterial PH domain; Region: DUF304; pfam03703 234621006767 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 234621006768 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234621006769 active site 234621006770 phosphorylation site [posttranslational modification] 234621006771 intermolecular recognition site; other site 234621006772 dimerization interface [polypeptide binding]; other site 234621006773 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 234621006774 DNA binding site [nucleotide binding] 234621006775 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 234621006776 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234621006777 dimer interface [polypeptide binding]; other site 234621006778 phosphorylation site [posttranslational modification] 234621006779 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234621006780 ATP binding site [chemical binding]; other site 234621006781 Mg2+ binding site [ion binding]; other site 234621006782 G-X-G motif; other site 234621006783 Predicted membrane protein [Function unknown]; Region: COG2246 234621006784 GtrA-like protein; Region: GtrA; pfam04138 234621006785 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 234621006786 ATP-grasp domain; Region: ATP-grasp; pfam02222 234621006787 AIR carboxylase; Region: AIRC; pfam00731 234621006788 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 234621006789 Histidine kinase; Region: HisKA_3; pfam07730 234621006790 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234621006791 ATP binding site [chemical binding]; other site 234621006792 Mg2+ binding site [ion binding]; other site 234621006793 G-X-G motif; other site 234621006794 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 234621006795 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234621006796 active site 234621006797 phosphorylation site [posttranslational modification] 234621006798 intermolecular recognition site; other site 234621006799 dimerization interface [polypeptide binding]; other site 234621006800 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 234621006801 DNA binding residues [nucleotide binding] 234621006802 dimerization interface [polypeptide binding]; other site 234621006803 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 234621006804 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 234621006805 Walker A/P-loop; other site 234621006806 ATP binding site [chemical binding]; other site 234621006807 Q-loop/lid; other site 234621006808 ABC transporter signature motif; other site 234621006809 Walker B; other site 234621006810 D-loop; other site 234621006811 H-loop/switch region; other site 234621006812 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 234621006813 FtsX-like permease family; Region: FtsX; pfam02687 234621006814 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 234621006815 FtsX-like permease family; Region: FtsX; pfam02687 234621006816 TIGR03089 family protein; Region: TIGR03089 234621006817 Transcriptional regulator [Transcription]; Region: LytR; COG1316 234621006818 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 234621006819 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 234621006820 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 234621006821 NADP binding site [chemical binding]; other site 234621006822 active site 234621006823 putative substrate binding site [chemical binding]; other site 234621006824 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 234621006825 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 234621006826 Probable Catalytic site; other site 234621006827 metal-binding site 234621006828 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 234621006829 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 234621006830 active site 234621006831 Substrate binding site; other site 234621006832 Mg++ binding site; other site 234621006833 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 234621006834 N-terminal domain interface [polypeptide binding]; other site 234621006835 sulfate 1 binding site; other site 234621006836 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 234621006837 active site 234621006838 catalytic triad [active] 234621006839 oxyanion hole [active] 234621006840 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 234621006841 nudix motif; other site 234621006842 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 234621006843 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 234621006844 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 234621006845 putative FMN binding site [chemical binding]; other site 234621006846 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 234621006847 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 234621006848 phosphate binding site [ion binding]; other site 234621006849 dimer interface [polypeptide binding]; other site 234621006850 substrate binding site [chemical binding]; other site 234621006851 Transcription factor WhiB; Region: Whib; pfam02467 234621006852 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 234621006853 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 234621006854 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 234621006855 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 234621006856 active site 234621006857 substrate binding site [chemical binding]; other site 234621006858 metal binding site [ion binding]; metal-binding site 234621006859 bifunctional phosphoglucose/phosphomannose isomerase; Validated; Region: PRK08674 234621006860 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 234621006861 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 234621006862 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 234621006863 Cation efflux family; Region: Cation_efflux; pfam01545 234621006864 amino acid transporter; Region: 2A0306; TIGR00909 234621006865 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 234621006866 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 234621006867 Fatty acid desaturase; Region: FA_desaturase; pfam00487 234621006868 Di-iron ligands [ion binding]; other site 234621006869 Rubredoxin [Energy production and conversion]; Region: COG1773 234621006870 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 234621006871 iron binding site [ion binding]; other site 234621006872 Rubredoxin [Energy production and conversion]; Region: COG1773 234621006873 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 234621006874 iron binding site [ion binding]; other site 234621006875 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621006876 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621006877 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 234621006878 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 234621006879 homotetramer interface [polypeptide binding]; other site 234621006880 ligand binding site [chemical binding]; other site 234621006881 catalytic site [active] 234621006882 NAD binding site [chemical binding]; other site 234621006883 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 234621006884 Thymidylate kinase; Region: Thymidylate_kin; pfam02223 234621006885 TMP-binding site; other site 234621006886 ATP-binding site [chemical binding]; other site 234621006887 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 234621006888 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234621006889 active site 234621006890 phosphorylation site [posttranslational modification] 234621006891 intermolecular recognition site; other site 234621006892 dimerization interface [polypeptide binding]; other site 234621006893 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 234621006894 DNA binding site [nucleotide binding] 234621006895 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 234621006896 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 234621006897 dimerization interface [polypeptide binding]; other site 234621006898 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234621006899 dimer interface [polypeptide binding]; other site 234621006900 phosphorylation site [posttranslational modification] 234621006901 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234621006902 ATP binding site [chemical binding]; other site 234621006903 Mg2+ binding site [ion binding]; other site 234621006904 G-X-G motif; other site 234621006905 lipoprotein LpqB; Provisional; Region: PRK13616 234621006906 Sporulation and spore germination; Region: Germane; pfam10646 234621006907 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 234621006908 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 234621006909 30S subunit binding site; other site 234621006910 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 234621006911 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 234621006912 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 234621006913 nucleotide binding region [chemical binding]; other site 234621006914 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 234621006915 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 234621006916 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 234621006917 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 234621006918 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 234621006919 FAD binding pocket [chemical binding]; other site 234621006920 FAD binding motif [chemical binding]; other site 234621006921 phosphate binding motif [ion binding]; other site 234621006922 beta-alpha-beta structure motif; other site 234621006923 NAD binding pocket [chemical binding]; other site 234621006924 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 234621006925 catalytic loop [active] 234621006926 iron binding site [ion binding]; other site 234621006927 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 234621006928 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 234621006929 putative di-iron ligands [ion binding]; other site 234621006930 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 234621006931 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 234621006932 putative di-iron ligands [ion binding]; other site 234621006933 Predicted GTPases [General function prediction only]; Region: COG1162 234621006934 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 234621006935 GTPase/Zn-binding domain interface [polypeptide binding]; other site 234621006936 GTP/Mg2+ binding site [chemical binding]; other site 234621006937 G4 box; other site 234621006938 G5 box; other site 234621006939 G1 box; other site 234621006940 Switch I region; other site 234621006941 G2 box; other site 234621006942 G3 box; other site 234621006943 Switch II region; other site 234621006944 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 234621006945 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 234621006946 hinge; other site 234621006947 active site 234621006948 Uncharacterized conserved protein [Function unknown]; Region: COG2135 234621006949 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 234621006950 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 234621006951 putative deacylase active site [active] 234621006952 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 234621006953 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234621006954 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234621006955 DNA binding residues [nucleotide binding] 234621006956 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 234621006957 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 234621006958 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 234621006959 carboxyltransferase (CT) interaction site; other site 234621006960 biotinylation site [posttranslational modification]; other site 234621006961 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 234621006962 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 234621006963 Histidine kinase; Region: HisKA_2; pfam07568 234621006964 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234621006965 ATP binding site [chemical binding]; other site 234621006966 Mg2+ binding site [ion binding]; other site 234621006967 G-X-G motif; other site 234621006968 Transcription factor WhiB; Region: Whib; pfam02467 234621006969 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 234621006970 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 234621006971 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 234621006972 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 234621006973 Coenzyme A binding pocket [chemical binding]; other site 234621006974 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 234621006975 catalytic core [active] 234621006976 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 234621006977 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 234621006978 P-loop; other site 234621006979 Magnesium ion binding site [ion binding]; other site 234621006980 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 234621006981 Magnesium ion binding site [ion binding]; other site 234621006982 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 234621006983 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 234621006984 ATP binding site [chemical binding]; other site 234621006985 putative Mg++ binding site [ion binding]; other site 234621006986 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 234621006987 nucleotide binding region [chemical binding]; other site 234621006988 ATP-binding site [chemical binding]; other site 234621006989 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 234621006990 dinuclear metal binding motif [ion binding]; other site 234621006991 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 234621006992 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621006993 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621006994 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 234621006995 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 234621006996 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 234621006997 ATP binding site [chemical binding]; other site 234621006998 substrate interface [chemical binding]; other site 234621006999 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 234621007000 active site residue [active] 234621007001 TIGR02569 family protein; Region: TIGR02569_actnb 234621007002 Transcriptional regulators [Transcription]; Region: FadR; COG2186 234621007003 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 234621007004 DNA-binding site [nucleotide binding]; DNA binding site 234621007005 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 234621007006 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 234621007007 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621007008 putative substrate translocation pore; other site 234621007009 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 234621007010 nitrite reductase subunit NirD; Provisional; Region: PRK14989 234621007011 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 234621007012 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 234621007013 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 234621007014 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 234621007015 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 234621007016 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 234621007017 active site 234621007018 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 234621007019 DNA binding site [nucleotide binding] 234621007020 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 234621007021 putative active site [active] 234621007022 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 234621007023 active site 234621007024 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 234621007025 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 234621007026 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 234621007027 GTP binding site; other site 234621007028 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 234621007029 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 234621007030 dimer interface [polypeptide binding]; other site 234621007031 putative functional site; other site 234621007032 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 234621007033 active site 234621007034 DNA binding site [nucleotide binding] 234621007035 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 234621007036 Serine hydrolase; Region: Ser_hydrolase; cl17834 234621007037 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 234621007038 catalytic site [active] 234621007039 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 234621007040 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 234621007041 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 234621007042 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 234621007043 Part of AAA domain; Region: AAA_19; pfam13245 234621007044 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 234621007045 Predicted membrane protein [Function unknown]; Region: COG4270 234621007046 Ion channel; Region: Ion_trans_2; pfam07885 234621007047 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 234621007048 TrkA-N domain; Region: TrkA_N; pfam02254 234621007049 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 234621007050 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 234621007051 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 234621007052 putative NADH binding site [chemical binding]; other site 234621007053 putative active site [active] 234621007054 nudix motif; other site 234621007055 putative metal binding site [ion binding]; other site 234621007056 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 234621007057 catalytic residues [active] 234621007058 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 234621007059 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 234621007060 Family description; Region: UvrD_C_2; pfam13538 234621007061 HRDC domain; Region: HRDC; pfam00570 234621007062 Transcription factor WhiB; Region: Whib; pfam02467 234621007063 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 234621007064 ABC1 family; Region: ABC1; pfam03109 234621007065 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 234621007066 active site 234621007067 ATP binding site [chemical binding]; other site 234621007068 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 234621007069 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 234621007070 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 234621007071 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 234621007072 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 234621007073 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 234621007074 hypothetical protein; Provisional; Region: PRK12438 234621007075 hypothetical protein; Validated; Region: PRK00068 234621007076 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 234621007077 Lipase (class 2); Region: Lipase_2; pfam01674 234621007078 Transcriptional regulators [Transcription]; Region: GntR; COG1802 234621007079 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 234621007080 DNA-binding site [nucleotide binding]; DNA binding site 234621007081 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 234621007082 oxidase reductase; Provisional; Region: PTZ00273 234621007083 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 234621007084 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 234621007085 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 234621007086 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234621007087 dimer interface [polypeptide binding]; other site 234621007088 conserved gate region; other site 234621007089 putative PBP binding loops; other site 234621007090 ABC-ATPase subunit interface; other site 234621007091 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 234621007092 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 234621007093 Walker A/P-loop; other site 234621007094 ATP binding site [chemical binding]; other site 234621007095 Q-loop/lid; other site 234621007096 ABC transporter signature motif; other site 234621007097 Walker B; other site 234621007098 D-loop; other site 234621007099 H-loop/switch region; other site 234621007100 oxidase reductase; Provisional; Region: PTZ00273 234621007101 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 234621007102 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 234621007103 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 234621007104 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234621007105 active site 234621007106 acyl-CoA synthetase; Validated; Region: PRK07788 234621007107 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621007108 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621007109 acyl-activating enzyme (AAE) consensus motif; other site 234621007110 AMP binding site [chemical binding]; other site 234621007111 active site 234621007112 CoA binding site [chemical binding]; other site 234621007113 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621007114 active site 234621007115 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 234621007116 Fic family protein [Function unknown]; Region: COG3177 234621007117 Fic/DOC family; Region: Fic; pfam02661 234621007118 Phage tail repeat like; Region: PTR; pfam12789 234621007119 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 234621007120 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 234621007121 Protein of unknown function (DUF2744); Region: DUF2744; pfam10910 234621007122 tape measure domain; Region: tape_meas_nterm; TIGR02675 234621007123 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 234621007124 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 234621007125 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 234621007126 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 234621007127 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280 234621007128 active site 234621007129 putative DNA-binding cleft [nucleotide binding]; other site 234621007130 dimer interface [polypeptide binding]; other site 234621007131 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 234621007132 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 234621007133 cofactor binding site; other site 234621007134 DNA binding site [nucleotide binding] 234621007135 substrate interaction site [chemical binding]; other site 234621007136 Helix-turn-helix domain; Region: HTH_17; cl17695 234621007137 HTH domain; Region: HTH_11; pfam08279 234621007138 Domain of unknown function (DUF955); Region: DUF955; pfam06114 234621007139 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 234621007140 active site 234621007141 DNA binding site [nucleotide binding] 234621007142 Int/Topo IB signature motif; other site 234621007143 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621007144 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621007145 active site 234621007146 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621007147 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621007148 active site 234621007149 Histidine kinase; Region: HisKA_3; pfam07730 234621007150 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 234621007151 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 234621007152 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234621007153 active site 234621007154 phosphorylation site [posttranslational modification] 234621007155 intermolecular recognition site; other site 234621007156 dimerization interface [polypeptide binding]; other site 234621007157 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 234621007158 DNA binding residues [nucleotide binding] 234621007159 dimerization interface [polypeptide binding]; other site 234621007160 FtsI repressor; Provisional; Region: PRK10883 234621007161 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 234621007162 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 234621007163 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 234621007164 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 234621007165 active site 234621007166 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 234621007167 active site clefts [active] 234621007168 zinc binding site [ion binding]; other site 234621007169 dimer interface [polypeptide binding]; other site 234621007170 peptide chain release factor 2; Validated; Region: prfB; PRK00578 234621007171 This domain is found in peptide chain release factors; Region: PCRF; smart00937 234621007172 RF-1 domain; Region: RF-1; pfam00472 234621007173 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 234621007174 Mechanosensitive ion channel; Region: MS_channel; pfam00924 234621007175 Membrane protein required for beta-lactamase induction [Defense mechanisms]; Region: AmpE; cl17896 234621007176 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 234621007177 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234621007178 Walker A/P-loop; other site 234621007179 ATP binding site [chemical binding]; other site 234621007180 Q-loop/lid; other site 234621007181 ABC transporter signature motif; other site 234621007182 Walker B; other site 234621007183 D-loop; other site 234621007184 H-loop/switch region; other site 234621007185 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 234621007186 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 234621007187 SmpB-tmRNA interface; other site 234621007188 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 234621007189 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234621007190 non-specific DNA binding site [nucleotide binding]; other site 234621007191 salt bridge; other site 234621007192 sequence-specific DNA binding site [nucleotide binding]; other site 234621007193 Cupin domain; Region: Cupin_2; pfam07883 234621007194 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 234621007195 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 234621007196 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 234621007197 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 234621007198 putative NAD(P) binding site [chemical binding]; other site 234621007199 putative active site [active] 234621007200 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 234621007201 Uncharacterized conserved protein [Function unknown]; Region: COG3379 234621007202 BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463 234621007203 Domain of unknown function (DUF222); Region: DUF222; pfam02720 234621007204 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 234621007205 active site 234621007206 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 234621007207 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 234621007208 Coenzyme A binding pocket [chemical binding]; other site 234621007209 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 234621007210 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 234621007211 catalytic site [active] 234621007212 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 234621007213 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 234621007214 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 234621007215 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 234621007216 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 234621007217 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234621007218 S-adenosylmethionine binding site [chemical binding]; other site 234621007219 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 234621007220 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234621007221 S-adenosylmethionine binding site [chemical binding]; other site 234621007222 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 234621007223 CrcB-like protein; Region: CRCB; pfam02537 234621007224 camphor resistance protein CrcB; Provisional; Region: PRK14211 234621007225 phosphoglucomutase; Validated; Region: PRK07564 234621007226 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 234621007227 active site 234621007228 substrate binding site [chemical binding]; other site 234621007229 metal binding site [ion binding]; metal-binding site 234621007230 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621007231 Major Facilitator Superfamily; Region: MFS_1; pfam07690 234621007232 putative substrate translocation pore; other site 234621007233 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 234621007234 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 234621007235 catalytic residues [active] 234621007236 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 234621007237 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 234621007238 NAD binding site [chemical binding]; other site 234621007239 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 234621007240 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 234621007241 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 234621007242 AMP-binding enzyme; Region: AMP-binding; pfam00501 234621007243 acyl-activating enzyme (AAE) consensus motif; other site 234621007244 AMP binding site [chemical binding]; other site 234621007245 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 234621007246 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 234621007247 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 234621007248 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 234621007249 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 234621007250 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 234621007251 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 234621007252 putative FMN binding site [chemical binding]; other site 234621007253 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 234621007254 DEAD-like helicases superfamily; Region: DEXDc; smart00487 234621007255 ATP binding site [chemical binding]; other site 234621007256 putative Mg++ binding site [ion binding]; other site 234621007257 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 234621007258 nucleotide binding region [chemical binding]; other site 234621007259 ATP-binding site [chemical binding]; other site 234621007260 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 234621007261 MoaE homodimer interface [polypeptide binding]; other site 234621007262 MoaD interaction [polypeptide binding]; other site 234621007263 active site residues [active] 234621007264 bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional; Region: moaC; PRK03604 234621007265 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 234621007266 trimer interface [polypeptide binding]; other site 234621007267 dimer interface [polypeptide binding]; other site 234621007268 putative active site [active] 234621007269 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 234621007270 MPT binding site; other site 234621007271 trimer interface [polypeptide binding]; other site 234621007272 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 234621007273 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 234621007274 dimer interface [polypeptide binding]; other site 234621007275 putative functional site; other site 234621007276 putative MPT binding site; other site 234621007277 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 234621007278 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 234621007279 FeS/SAM binding site; other site 234621007280 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 234621007281 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 234621007282 MoaE interaction surface [polypeptide binding]; other site 234621007283 MoeB interaction surface [polypeptide binding]; other site 234621007284 thiocarboxylated glycine; other site 234621007285 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 234621007286 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 234621007287 homodimer interface [polypeptide binding]; other site 234621007288 NAD binding pocket [chemical binding]; other site 234621007289 ATP binding pocket [chemical binding]; other site 234621007290 Mg binding site [ion binding]; other site 234621007291 active-site loop [active] 234621007292 nucleosidase; Provisional; Region: PRK05634 234621007293 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 234621007294 META domain; Region: META; pfam03724 234621007295 META domain; Region: META; pfam03724 234621007296 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621007297 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621007298 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 234621007299 Predicted flavoprotein [General function prediction only]; Region: COG0431 234621007300 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 234621007301 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 234621007302 FAD binding pocket [chemical binding]; other site 234621007303 FAD binding motif [chemical binding]; other site 234621007304 phosphate binding motif [ion binding]; other site 234621007305 NAD binding pocket [chemical binding]; other site 234621007306 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 234621007307 catalytic residues [active] 234621007308 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 234621007309 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 234621007310 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 234621007311 Class I ribonucleotide reductase; Region: RNR_I; cd01679 234621007312 active site 234621007313 dimer interface [polypeptide binding]; other site 234621007314 catalytic residues [active] 234621007315 effector binding site; other site 234621007316 R2 peptide binding site; other site 234621007317 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 234621007318 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 234621007319 dimer interface [polypeptide binding]; other site 234621007320 putative radical transfer pathway; other site 234621007321 diiron center [ion binding]; other site 234621007322 tyrosyl radical; other site 234621007323 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 234621007324 nudix motif; other site 234621007325 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 234621007326 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 234621007327 siderophore binding site; other site 234621007328 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 234621007329 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 234621007330 siderophore binding site; other site 234621007331 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 234621007332 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 234621007333 D-pathway; other site 234621007334 Putative ubiquinol binding site [chemical binding]; other site 234621007335 Low-spin heme (heme b) binding site [chemical binding]; other site 234621007336 Putative water exit pathway; other site 234621007337 Binuclear center (heme o3/CuB) [ion binding]; other site 234621007338 K-pathway; other site 234621007339 Putative proton exit pathway; other site 234621007340 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 234621007341 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 234621007342 phosphoserine phosphatase SerB; Region: serB; TIGR00338 234621007343 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 234621007344 motif II; other site 234621007345 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 234621007346 dimer interface [polypeptide binding]; other site 234621007347 putative active site [active] 234621007348 Predicted membrane protein [Function unknown]; Region: COG2364 234621007349 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 234621007350 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 234621007351 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 234621007352 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 234621007353 active site 234621007354 catalytic site [active] 234621007355 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 234621007356 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234621007357 Walker A/P-loop; other site 234621007358 ATP binding site [chemical binding]; other site 234621007359 Q-loop/lid; other site 234621007360 ABC transporter signature motif; other site 234621007361 Walker B; other site 234621007362 D-loop; other site 234621007363 H-loop/switch region; other site 234621007364 enoyl-CoA hydratase; Provisional; Region: PRK07657 234621007365 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 234621007366 substrate binding site [chemical binding]; other site 234621007367 oxyanion hole (OAH) forming residues; other site 234621007368 trimer interface [polypeptide binding]; other site 234621007369 Methyltransferase domain; Region: Methyltransf_31; pfam13847 234621007370 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234621007371 S-adenosylmethionine binding site [chemical binding]; other site 234621007372 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 234621007373 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 234621007374 Trp docking motif [polypeptide binding]; other site 234621007375 active site 234621007376 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 234621007377 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 234621007378 trimer interface [polypeptide binding]; other site 234621007379 active site 234621007380 substrate binding site [chemical binding]; other site 234621007381 CoA binding site [chemical binding]; other site 234621007382 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 234621007383 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 234621007384 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 234621007385 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 234621007386 Uncharacterized conserved protein [Function unknown]; Region: COG1543 234621007387 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 234621007388 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 234621007389 Methyltransferase domain; Region: Methyltransf_23; pfam13489 234621007390 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234621007391 S-adenosylmethionine binding site [chemical binding]; other site 234621007392 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 234621007393 Ligand binding site [chemical binding]; other site 234621007394 Electron transfer flavoprotein domain; Region: ETF; pfam01012 234621007395 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 234621007396 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 234621007397 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 234621007398 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 234621007399 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 234621007400 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 234621007401 putative acyl-acceptor binding pocket; other site 234621007402 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 234621007403 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 234621007404 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 234621007405 catalytic residue [active] 234621007406 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 234621007407 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 234621007408 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 234621007409 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 234621007410 nucleotide binding pocket [chemical binding]; other site 234621007411 K-X-D-G motif; other site 234621007412 catalytic site [active] 234621007413 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 234621007414 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 234621007415 Helix-hairpin-helix motif; Region: HHH; pfam00633 234621007416 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 234621007417 Dimer interface [polypeptide binding]; other site 234621007418 BRCT sequence motif; other site 234621007419 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 234621007420 Coenzyme A binding pocket [chemical binding]; other site 234621007421 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 234621007422 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 234621007423 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 234621007424 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 234621007425 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 234621007426 Prokaryotic phospholipase A2; Region: Phospholip_A2_3; pfam09056 234621007427 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 234621007428 Histidine kinase; Region: HisKA_3; pfam07730 234621007429 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 234621007430 ATP binding site [chemical binding]; other site 234621007431 Mg2+ binding site [ion binding]; other site 234621007432 G-X-G motif; other site 234621007433 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 234621007434 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234621007435 active site 234621007436 phosphorylation site [posttranslational modification] 234621007437 intermolecular recognition site; other site 234621007438 dimerization interface [polypeptide binding]; other site 234621007439 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 234621007440 DNA binding residues [nucleotide binding] 234621007441 dimerization interface [polypeptide binding]; other site 234621007442 6-phosphofructokinase; Provisional; Region: PRK03202 234621007443 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 234621007444 active site 234621007445 ADP/pyrophosphate binding site [chemical binding]; other site 234621007446 dimerization interface [polypeptide binding]; other site 234621007447 allosteric effector site; other site 234621007448 fructose-1,6-bisphosphate binding site; other site 234621007449 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 234621007450 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 234621007451 GatB domain; Region: GatB_Yqey; smart00845 234621007452 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 234621007453 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 234621007454 NAD binding site [chemical binding]; other site 234621007455 substrate binding site [chemical binding]; other site 234621007456 catalytic Zn binding site [ion binding]; other site 234621007457 structural Zn binding site [ion binding]; other site 234621007458 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 234621007459 Predicted membrane protein [Function unknown]; Region: COG2259 234621007460 amino acid transporter; Region: 2A0306; TIGR00909 234621007461 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 234621007462 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 234621007463 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 234621007464 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 234621007465 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 234621007466 PYR/PP interface [polypeptide binding]; other site 234621007467 dimer interface [polypeptide binding]; other site 234621007468 TPP binding site [chemical binding]; other site 234621007469 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 234621007470 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 234621007471 TPP-binding site [chemical binding]; other site 234621007472 dimer interface [polypeptide binding]; other site 234621007473 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 234621007474 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 234621007475 putative valine binding site [chemical binding]; other site 234621007476 dimer interface [polypeptide binding]; other site 234621007477 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 234621007478 ketol-acid reductoisomerase; Provisional; Region: PRK05479 234621007479 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 234621007480 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 234621007481 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 234621007482 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 234621007483 ligand binding site [chemical binding]; other site 234621007484 NAD binding site [chemical binding]; other site 234621007485 dimerization interface [polypeptide binding]; other site 234621007486 catalytic site [active] 234621007487 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 234621007488 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 234621007489 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 234621007490 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 234621007491 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 234621007492 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 234621007493 Fatty acid desaturase; Region: FA_desaturase; pfam00487 234621007494 Di-iron ligands [ion binding]; other site 234621007495 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 234621007496 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 234621007497 active site 234621007498 HIGH motif; other site 234621007499 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 234621007500 active site 234621007501 KMSKS motif; other site 234621007502 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 234621007503 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 234621007504 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 234621007505 Transcriptional regulator [Transcription]; Region: IclR; COG1414 234621007506 Bacterial transcriptional regulator; Region: IclR; pfam01614 234621007507 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 234621007508 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 234621007509 substrate binding site [chemical binding]; other site 234621007510 ligand binding site [chemical binding]; other site 234621007511 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 234621007512 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 234621007513 substrate binding site [chemical binding]; other site 234621007514 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 234621007515 IHF - DNA interface [nucleotide binding]; other site 234621007516 IHF dimer interface [polypeptide binding]; other site 234621007517 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 234621007518 active site 234621007519 Ap6A binding site [chemical binding]; other site 234621007520 nudix motif; other site 234621007521 metal binding site [ion binding]; metal-binding site 234621007522 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 234621007523 catalytic core [active] 234621007524 polyphosphate kinase; Provisional; Region: PRK05443 234621007525 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 234621007526 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 234621007527 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 234621007528 putative domain interface [polypeptide binding]; other site 234621007529 putative active site [active] 234621007530 catalytic site [active] 234621007531 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 234621007532 putative domain interface [polypeptide binding]; other site 234621007533 putative active site [active] 234621007534 catalytic site [active] 234621007535 2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552 234621007536 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 234621007537 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 234621007538 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 234621007539 cystathionine gamma-lyase; Validated; Region: PRK07582 234621007540 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 234621007541 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 234621007542 catalytic residue [active] 234621007543 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 234621007544 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 234621007545 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 234621007546 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 234621007547 thiamine monophosphate kinase; Provisional; Region: PRK05731 234621007548 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 234621007549 ATP binding site [chemical binding]; other site 234621007550 dimerization interface [polypeptide binding]; other site 234621007551 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 234621007552 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 234621007553 trimer interface [polypeptide binding]; other site 234621007554 putative metal binding site [ion binding]; other site 234621007555 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 234621007556 ligand binding site [chemical binding]; other site 234621007557 active site 234621007558 UGI interface [polypeptide binding]; other site 234621007559 catalytic site [active] 234621007560 enoyl-CoA hydratase; Provisional; Region: PRK06688 234621007561 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 234621007562 substrate binding site [chemical binding]; other site 234621007563 oxyanion hole (OAH) forming residues; other site 234621007564 trimer interface [polypeptide binding]; other site 234621007565 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 234621007566 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 234621007567 DAK2 domain; Region: Dak2; pfam02734 234621007568 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 234621007569 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 234621007570 generic binding surface II; other site 234621007571 ssDNA binding site; other site 234621007572 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 234621007573 ATP binding site [chemical binding]; other site 234621007574 putative Mg++ binding site [ion binding]; other site 234621007575 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 234621007576 nucleotide binding region [chemical binding]; other site 234621007577 ATP-binding site [chemical binding]; other site 234621007578 pyruvate carboxylase; Reviewed; Region: PRK12999 234621007579 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 234621007580 ATP-grasp domain; Region: ATP-grasp_4; cl17255 234621007581 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 234621007582 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 234621007583 active site 234621007584 catalytic residues [active] 234621007585 metal binding site [ion binding]; metal-binding site 234621007586 homodimer binding site [polypeptide binding]; other site 234621007587 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 234621007588 carboxyltransferase (CT) interaction site; other site 234621007589 biotinylation site [posttranslational modification]; other site 234621007590 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 234621007591 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234621007592 S-adenosylmethionine binding site [chemical binding]; other site 234621007593 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 234621007594 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 234621007595 active site 234621007596 (T/H)XGH motif; other site 234621007597 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 234621007598 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 234621007599 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 234621007600 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 234621007601 ribonuclease III; Reviewed; Region: rnc; PRK00102 234621007602 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 234621007603 dimerization interface [polypeptide binding]; other site 234621007604 active site 234621007605 metal binding site [ion binding]; metal-binding site 234621007606 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 234621007607 dsRNA binding site [nucleotide binding]; other site 234621007608 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 234621007609 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 234621007610 DNA binding site [nucleotide binding] 234621007611 catalytic residue [active] 234621007612 H2TH interface [polypeptide binding]; other site 234621007613 putative catalytic residues [active] 234621007614 turnover-facilitating residue; other site 234621007615 intercalation triad [nucleotide binding]; other site 234621007616 8OG recognition residue [nucleotide binding]; other site 234621007617 putative reading head residues; other site 234621007618 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 234621007619 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 234621007620 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 234621007621 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 234621007622 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 234621007623 acylphosphatase; Provisional; Region: PRK14422 234621007624 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 234621007625 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 234621007626 Walker A/P-loop; other site 234621007627 ATP binding site [chemical binding]; other site 234621007628 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 234621007629 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 234621007630 ABC transporter signature motif; other site 234621007631 Walker B; other site 234621007632 D-loop; other site 234621007633 H-loop/switch region; other site 234621007634 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 234621007635 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 234621007636 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 234621007637 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 234621007638 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 234621007639 Nitrogen regulatory protein P-II; Region: P-II; smart00938 234621007640 PII uridylyl-transferase; Provisional; Region: PRK03381 234621007641 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 234621007642 metal binding triad; other site 234621007643 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 234621007644 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 234621007645 Zn2+ binding site [ion binding]; other site 234621007646 Mg2+ binding site [ion binding]; other site 234621007647 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 234621007648 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 234621007649 signal recognition particle protein; Provisional; Region: PRK10867 234621007650 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 234621007651 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 234621007652 P loop; other site 234621007653 GTP binding site [chemical binding]; other site 234621007654 Signal peptide binding domain; Region: SRP_SPB; pfam02978 234621007655 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 234621007656 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234621007657 active site 234621007658 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 234621007659 hypothetical protein; Provisional; Region: PRK02821 234621007660 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 234621007661 G-X-X-G motif; other site 234621007662 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 234621007663 RimM N-terminal domain; Region: RimM; pfam01782 234621007664 PRC-barrel domain; Region: PRC; pfam05239 234621007665 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 234621007666 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 234621007667 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 234621007668 NADP+ binding site [chemical binding]; other site 234621007669 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621007670 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621007671 Predicted membrane protein [Function unknown]; Region: COG2246 234621007672 GtrA-like protein; Region: GtrA; pfam04138 234621007673 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 234621007674 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 234621007675 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 234621007676 active site 234621007677 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 234621007678 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 234621007679 inhibitor-cofactor binding pocket; inhibition site 234621007680 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234621007681 catalytic residue [active] 234621007682 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 234621007683 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 234621007684 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 234621007685 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 234621007686 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 234621007687 RNA binding site [nucleotide binding]; other site 234621007688 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 234621007689 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 234621007690 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 234621007691 Catalytic site [active] 234621007692 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 234621007693 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 234621007694 RNA/DNA hybrid binding site [nucleotide binding]; other site 234621007695 active site 234621007696 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 234621007697 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 234621007698 transposase/IS protein; Provisional; Region: PRK09183 234621007699 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234621007700 Walker A motif; other site 234621007701 ATP binding site [chemical binding]; other site 234621007702 Walker B motif; other site 234621007703 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 234621007704 Integrase core domain; Region: rve; pfam00665 234621007705 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 234621007706 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 234621007707 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 234621007708 siderophore binding site; other site 234621007709 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 234621007710 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 234621007711 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 234621007712 hypothetical protein; Reviewed; Region: PRK12497 234621007713 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 234621007714 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 234621007715 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 234621007716 HNH endonuclease; Region: HNH_3; pfam13392 234621007717 DNA-binding domain found in transcription regulators in plants such as APETALA2 and EREBP (ethylene responsive element binding protein). In EREBPs the domain specifically binds to the 11bp GCC box of the ethylene response element (ERE), a promotor...; Region: AP2; cl00033 234621007718 DNA binding site [nucleotide binding] 234621007719 Domain of unknown function (DUF3846); Region: DUF3846; pfam12957 234621007720 TIR domain; Region: TIR_2; pfam13676 234621007721 Helix-turn-helix domain; Region: HTH_39; pfam14090 234621007722 multiple promoter invertase; Provisional; Region: mpi; PRK13413 234621007723 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 234621007724 catalytic residues [active] 234621007725 catalytic nucleophile [active] 234621007726 Presynaptic Site I dimer interface [polypeptide binding]; other site 234621007727 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 234621007728 Synaptic Flat tetramer interface [polypeptide binding]; other site 234621007729 Synaptic Site I dimer interface [polypeptide binding]; other site 234621007730 DNA binding site [nucleotide binding] 234621007731 HNH endonuclease; Region: HNH_3; pfam13392 234621007732 ERF superfamily; Region: ERF; pfam04404 234621007733 Replication-relaxation; Region: Replic_Relax; pfam13814 234621007734 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 234621007735 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 234621007736 RNA ligase; Region: RNA_lig_T4_1; pfam09511 234621007737 polynucleotide kinase; Provisional; Region: pseT; PHA02530 234621007738 AAA domain; Region: AAA_17; pfam13207 234621007739 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 234621007740 Transglycosylase; Region: Transgly; cl17702 234621007741 YopX protein; Region: YopX; pfam09643 234621007742 Phage terminase large subunit; Region: Terminase_3; cl12054 234621007743 Terminase-like family; Region: Terminase_6; pfam03237 234621007744 Phage portal protein; Region: Phage_portal; pfam04860 234621007745 Phage-related protein [Function unknown]; Region: COG4695; cl01923 234621007746 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 234621007747 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 234621007748 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 234621007749 Phage capsid family; Region: Phage_capsid; pfam05065 234621007750 tape measure domain; Region: tape_meas_nterm; TIGR02675 234621007751 Phage tail protein; Region: Sipho_tail; cl17486 234621007752 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 234621007753 Lsr2; Region: Lsr2; pfam11774 234621007754 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 234621007755 AAA-like domain; Region: AAA_10; pfam12846 234621007756 Walker A motif; other site 234621007757 ATP binding site [chemical binding]; other site 234621007758 Walker B motif; other site 234621007759 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 234621007760 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 234621007761 catalytic residues [active] 234621007762 catalytic nucleophile [active] 234621007763 Recombinase; Region: Recombinase; pfam07508 234621007764 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 234621007765 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 234621007766 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 234621007767 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 234621007768 DNA protecting protein DprA; Region: dprA; TIGR00732 234621007769 Lsr2; Region: Lsr2; pfam11774 234621007770 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 234621007771 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 234621007772 FAD binding pocket [chemical binding]; other site 234621007773 FAD binding motif [chemical binding]; other site 234621007774 phosphate binding motif [ion binding]; other site 234621007775 NAD binding pocket [chemical binding]; other site 234621007776 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621007777 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 234621007778 putative substrate translocation pore; other site 234621007779 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 234621007780 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 234621007781 active site 234621007782 DNA binding site [nucleotide binding] 234621007783 Int/Topo IB signature motif; other site 234621007784 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 234621007785 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 234621007786 Peptidase family M23; Region: Peptidase_M23; pfam01551 234621007787 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 234621007788 rRNA interaction site [nucleotide binding]; other site 234621007789 S8 interaction site; other site 234621007790 putative laminin-1 binding site; other site 234621007791 elongation factor Ts; Provisional; Region: tsf; PRK09377 234621007792 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 234621007793 Elongation factor TS; Region: EF_TS; pfam00889 234621007794 Elongation factor TS; Region: EF_TS; pfam00889 234621007795 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 234621007796 putative nucleotide binding site [chemical binding]; other site 234621007797 uridine monophosphate binding site [chemical binding]; other site 234621007798 homohexameric interface [polypeptide binding]; other site 234621007799 ribosome recycling factor; Reviewed; Region: frr; PRK00083 234621007800 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 234621007801 hinge region; other site 234621007802 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 234621007803 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 234621007804 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234621007805 S-adenosylmethionine binding site [chemical binding]; other site 234621007806 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 234621007807 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 234621007808 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 234621007809 FeS/SAM binding site; other site 234621007810 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 234621007811 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 234621007812 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 234621007813 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 234621007814 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 234621007815 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 234621007816 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 234621007817 active site 234621007818 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 234621007819 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 234621007820 putative substrate binding region [chemical binding]; other site 234621007821 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 234621007822 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 234621007823 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 234621007824 Predicted acetyltransferase [General function prediction only]; Region: COG3393 234621007825 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 234621007826 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 234621007827 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 234621007828 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 234621007829 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 234621007830 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 234621007831 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 234621007832 DNA binding residues [nucleotide binding] 234621007833 dimerization interface [polypeptide binding]; other site 234621007834 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 234621007835 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621007836 acyl-activating enzyme (AAE) consensus motif; other site 234621007837 AMP binding site [chemical binding]; other site 234621007838 active site 234621007839 CoA binding site [chemical binding]; other site 234621007840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234621007841 dimer interface [polypeptide binding]; other site 234621007842 conserved gate region; other site 234621007843 ABC-ATPase subunit interface; other site 234621007844 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 234621007845 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234621007846 dimer interface [polypeptide binding]; other site 234621007847 conserved gate region; other site 234621007848 putative PBP binding loops; other site 234621007849 ABC-ATPase subunit interface; other site 234621007850 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 234621007851 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234621007852 Walker A/P-loop; other site 234621007853 ATP binding site [chemical binding]; other site 234621007854 Q-loop/lid; other site 234621007855 ABC transporter signature motif; other site 234621007856 Walker B; other site 234621007857 D-loop; other site 234621007858 H-loop/switch region; other site 234621007859 TOBE domain; Region: TOBE_2; pfam08402 234621007860 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 234621007861 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 234621007862 phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351 234621007863 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 234621007864 motif II; other site 234621007865 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 234621007866 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 234621007867 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 234621007868 DNA-binding site [nucleotide binding]; DNA binding site 234621007869 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 234621007870 Methyltransferase domain; Region: Methyltransf_23; pfam13489 234621007871 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234621007872 S-adenosylmethionine binding site [chemical binding]; other site 234621007873 FAD binding domain; Region: FAD_binding_3; pfam01494 234621007874 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 234621007875 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621007876 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621007877 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 234621007878 Beta-lactamase; Region: Beta-lactamase; pfam00144 234621007879 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 234621007880 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 234621007881 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 234621007882 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 234621007883 amidohydrolase; Region: amidohydrolases; TIGR01891 234621007884 metal binding site [ion binding]; metal-binding site 234621007885 Protein of unknown function (DUF3100); Region: DUF3100; pfam11299 234621007886 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 234621007887 AsnC family; Region: AsnC_trans_reg; pfam01037 234621007888 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 234621007889 AsnC family; Region: AsnC_trans_reg; pfam01037 234621007890 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 234621007891 putative catalytic site [active] 234621007892 putative metal binding site [ion binding]; other site 234621007893 putative phosphate binding site [ion binding]; other site 234621007894 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 234621007895 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 234621007896 Sulfate transporter family; Region: Sulfate_transp; pfam00916 234621007897 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 234621007898 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 234621007899 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 234621007900 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 234621007901 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 234621007902 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 234621007903 motif II; other site 234621007904 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 234621007905 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 234621007906 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 234621007907 Short C-terminal domain; Region: SHOCT; pfam09851 234621007908 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 234621007909 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 234621007910 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 234621007911 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 234621007912 siderophore binding site; other site 234621007913 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 234621007914 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 234621007915 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 234621007916 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 234621007917 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 234621007918 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 234621007919 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 234621007920 active site 234621007921 cobyric acid synthase; Provisional; Region: PRK00784 234621007922 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 234621007923 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 234621007924 catalytic triad [active] 234621007925 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 234621007926 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234621007927 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234621007928 DNA binding residues [nucleotide binding] 234621007929 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 234621007930 GAF domain; Region: GAF_2; pfam13185 234621007931 ANTAR domain; Region: ANTAR; pfam03861 234621007932 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 234621007933 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 234621007934 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621007935 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621007936 enoyl-CoA hydratase; Provisional; Region: PRK08260 234621007937 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 234621007938 substrate binding site [chemical binding]; other site 234621007939 oxyanion hole (OAH) forming residues; other site 234621007940 trimer interface [polypeptide binding]; other site 234621007941 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 234621007942 Phosphotransferase enzyme family; Region: APH; pfam01636 234621007943 putative active site [active] 234621007944 putative substrate binding site [chemical binding]; other site 234621007945 ATP binding site [chemical binding]; other site 234621007946 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621007947 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621007948 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 234621007949 mycothione reductase; Reviewed; Region: PRK07846 234621007950 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 234621007951 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 234621007952 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 234621007953 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 234621007954 malate:quinone oxidoreductase; Validated; Region: PRK05257 234621007955 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 234621007956 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 234621007957 Coenzyme A binding pocket [chemical binding]; other site 234621007958 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 234621007959 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234621007960 Walker A motif; other site 234621007961 ATP binding site [chemical binding]; other site 234621007962 Walker B motif; other site 234621007963 arginine finger; other site 234621007964 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 234621007965 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 234621007966 metal ion-dependent adhesion site (MIDAS); other site 234621007967 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 234621007968 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 234621007969 Walker A motif; other site 234621007970 homodimer interface [polypeptide binding]; other site 234621007971 ATP binding site [chemical binding]; other site 234621007972 hydroxycobalamin binding site [chemical binding]; other site 234621007973 Walker B motif; other site 234621007974 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 234621007975 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 234621007976 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 234621007977 catalytic triad [active] 234621007978 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 234621007979 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 234621007980 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 234621007981 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 234621007982 active site 234621007983 SAM binding site [chemical binding]; other site 234621007984 homodimer interface [polypeptide binding]; other site 234621007985 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 234621007986 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621007987 putative substrate translocation pore; other site 234621007988 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 234621007989 FOG: CBS domain [General function prediction only]; Region: COG0517 234621007990 Uncharacterized conserved protein [Function unknown]; Region: COG0397 234621007991 hypothetical protein; Validated; Region: PRK00029 234621007992 hypothetical protein; Validated; Region: PRK02101 234621007993 prolyl-tRNA synthetase; Provisional; Region: PRK09194 234621007994 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 234621007995 motif 1; other site 234621007996 dimer interface [polypeptide binding]; other site 234621007997 active site 234621007998 motif 2; other site 234621007999 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 234621008000 putative deacylase active site [active] 234621008001 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 234621008002 active site 234621008003 motif 3; other site 234621008004 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 234621008005 anticodon binding site; other site 234621008006 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 234621008007 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234621008008 S-adenosylmethionine binding site [chemical binding]; other site 234621008009 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621008010 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 234621008011 active site 234621008012 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 234621008013 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 234621008014 Major Facilitator Superfamily; Region: MFS_1; pfam07690 234621008015 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621008016 putative substrate translocation pore; other site 234621008017 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 234621008018 EamA-like transporter family; Region: EamA; pfam00892 234621008019 short chain dehydrogenase; Provisional; Region: PRK08303 234621008020 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621008021 NAD(P) binding site [chemical binding]; other site 234621008022 active site 234621008023 SnoaL-like domain; Region: SnoaL_4; pfam13577 234621008024 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621008025 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621008026 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621008027 Major Facilitator Superfamily; Region: MFS_1; pfam07690 234621008028 putative substrate translocation pore; other site 234621008029 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 234621008030 dinuclear metal binding motif [ion binding]; other site 234621008031 ribosome maturation protein RimP; Reviewed; Region: PRK00092 234621008032 Sm and related proteins; Region: Sm_like; cl00259 234621008033 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 234621008034 NusA N-terminal domain; Region: NusA_N; pfam08529 234621008035 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 234621008036 RNA binding site [nucleotide binding]; other site 234621008037 homodimer interface [polypeptide binding]; other site 234621008038 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 234621008039 G-X-X-G motif; other site 234621008040 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 234621008041 G-X-X-G motif; other site 234621008042 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 234621008043 putative RNA binding cleft [nucleotide binding]; other site 234621008044 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 234621008045 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 234621008046 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 234621008047 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 234621008048 G1 box; other site 234621008049 putative GEF interaction site [polypeptide binding]; other site 234621008050 GTP/Mg2+ binding site [chemical binding]; other site 234621008051 Switch I region; other site 234621008052 G2 box; other site 234621008053 G3 box; other site 234621008054 Switch II region; other site 234621008055 G4 box; other site 234621008056 G5 box; other site 234621008057 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 234621008058 Translation-initiation factor 2; Region: IF-2; pfam11987 234621008059 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 234621008060 Protein of unknown function (DUF503); Region: DUF503; cl00669 234621008061 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 234621008062 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 234621008063 DHH family; Region: DHH; pfam01368 234621008064 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 234621008065 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 234621008066 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 234621008067 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 234621008068 active site 234621008069 metal binding site [ion binding]; metal-binding site 234621008070 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 234621008071 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 234621008072 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 234621008073 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 234621008074 RNA binding site [nucleotide binding]; other site 234621008075 active site 234621008076 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 234621008077 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 234621008078 Coenzyme A binding pocket [chemical binding]; other site 234621008079 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 234621008080 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 234621008081 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 234621008082 FeoA domain; Region: FeoA; pfam04023 234621008083 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 234621008084 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 234621008085 active site 234621008086 Riboflavin kinase; Region: Flavokinase; smart00904 234621008087 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 234621008088 16S/18S rRNA binding site [nucleotide binding]; other site 234621008089 S13e-L30e interaction site [polypeptide binding]; other site 234621008090 25S rRNA binding site [nucleotide binding]; other site 234621008091 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 234621008092 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 234621008093 oligomer interface [polypeptide binding]; other site 234621008094 RNA binding site [nucleotide binding]; other site 234621008095 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 234621008096 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 234621008097 RNase E interface [polypeptide binding]; other site 234621008098 trimer interface [polypeptide binding]; other site 234621008099 active site 234621008100 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 234621008101 putative nucleic acid binding region [nucleotide binding]; other site 234621008102 G-X-X-G motif; other site 234621008103 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 234621008104 RNA binding site [nucleotide binding]; other site 234621008105 domain interface; other site 234621008106 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 234621008107 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 234621008108 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 234621008109 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 234621008110 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 234621008111 NAD(P) binding site [chemical binding]; other site 234621008112 Cutinase; Region: Cutinase; pfam01083 234621008113 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 234621008114 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 234621008115 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 234621008116 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 234621008117 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 234621008118 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 234621008119 NifU-like domain; Region: NifU; cl00484 234621008120 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 234621008121 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 234621008122 Putative [NiFe] hydrogenase-specific C-terminal protease. Sequence comparison shows similarity to hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). Maturation of [FeNi] hydrogenases includes formation of...; Region: H2MP_like-1; cd06068 234621008123 nickel binding site [ion binding]; other site 234621008124 HupF/HypC family; Region: HupF_HypC; pfam01455 234621008125 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 234621008126 Acylphosphatase; Region: Acylphosphatase; pfam00708 234621008127 HypF finger; Region: zf-HYPF; pfam07503 234621008128 HypF finger; Region: zf-HYPF; pfam07503 234621008129 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 234621008130 HupF/HypC family; Region: HupF_HypC; pfam01455 234621008131 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 234621008132 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 234621008133 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 234621008134 dimerization interface [polypeptide binding]; other site 234621008135 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 234621008136 ATP binding site [chemical binding]; other site 234621008137 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 234621008138 active site 234621008139 Predicted transcriptional regulators [Transcription]; Region: COG1695 234621008140 Transcriptional regulator PadR-like family; Region: PadR; cl17335 234621008141 Beta-lactamase; Region: Beta-lactamase; pfam00144 234621008142 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 234621008143 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 234621008144 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 234621008145 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 234621008146 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 234621008147 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 234621008148 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 234621008149 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234621008150 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 234621008151 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 234621008152 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 234621008153 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 234621008154 Na binding site [ion binding]; other site 234621008155 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 234621008156 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 234621008157 active site 234621008158 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 234621008159 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 234621008160 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621008161 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621008162 WHG domain; Region: WHG; pfam13305 234621008163 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_6; cd01844 234621008164 active site 234621008165 catalytic triad [active] 234621008166 oxyanion hole [active] 234621008167 Domain of unknown function (DUF385); Region: DUF385; cl04387 234621008168 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 234621008169 active site 234621008170 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 234621008171 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 234621008172 DNA binding residues [nucleotide binding] 234621008173 dimer interface [polypeptide binding]; other site 234621008174 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 234621008175 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 234621008176 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 234621008177 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621008178 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621008179 Cobalt transport protein; Region: CbiQ; cl00463 234621008180 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 234621008181 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 234621008182 Walker A/P-loop; other site 234621008183 ATP binding site [chemical binding]; other site 234621008184 Q-loop/lid; other site 234621008185 ABC transporter signature motif; other site 234621008186 Walker B; other site 234621008187 D-loop; other site 234621008188 H-loop/switch region; other site 234621008189 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 234621008190 Walker A/P-loop; other site 234621008191 ATP binding site [chemical binding]; other site 234621008192 Q-loop/lid; other site 234621008193 ABC transporter signature motif; other site 234621008194 Walker B; other site 234621008195 D-loop; other site 234621008196 H-loop/switch region; other site 234621008197 dihydrodipicolinate reductase; Provisional; Region: PRK00048 234621008198 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 234621008199 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 234621008200 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 234621008201 Uncharacterized conserved protein [Function unknown]; Region: COG5649 234621008202 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 234621008203 Phosphopantetheine attachment site; Region: PP-binding; cl09936 234621008204 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316 234621008205 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621008206 NAD(P) binding site [chemical binding]; other site 234621008207 active site 234621008208 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 234621008209 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 234621008210 acyl-activating enzyme (AAE) consensus motif; other site 234621008211 active site 234621008212 AMP binding site [chemical binding]; other site 234621008213 substrate binding site [chemical binding]; other site 234621008214 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 234621008215 Isochorismatase family; Region: Isochorismatase; pfam00857 234621008216 catalytic triad [active] 234621008217 conserved cis-peptide bond; other site 234621008218 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 234621008219 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 234621008220 Condensation domain; Region: Condensation; pfam00668 234621008221 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 234621008222 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 234621008223 acyl-activating enzyme (AAE) consensus motif; other site 234621008224 AMP binding site [chemical binding]; other site 234621008225 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 234621008226 Condensation domain; Region: Condensation; pfam00668 234621008227 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 234621008228 Condensation domain; Region: Condensation; pfam00668 234621008229 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 234621008230 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 234621008231 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621008232 AMP-binding enzyme; Region: AMP-binding; pfam00501 234621008233 acyl-activating enzyme (AAE) consensus motif; other site 234621008234 AMP binding site [chemical binding]; other site 234621008235 active site 234621008236 CoA binding site [chemical binding]; other site 234621008237 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 234621008238 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 234621008239 acyl-activating enzyme (AAE) consensus motif; other site 234621008240 AMP binding site [chemical binding]; other site 234621008241 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 234621008242 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 234621008243 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 234621008244 intersubunit interface [polypeptide binding]; other site 234621008245 enterobactin exporter EntS; Provisional; Region: PRK10489 234621008246 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621008247 putative substrate translocation pore; other site 234621008248 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 234621008249 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 234621008250 FAD binding pocket [chemical binding]; other site 234621008251 FAD binding motif [chemical binding]; other site 234621008252 phosphate binding motif [ion binding]; other site 234621008253 NAD binding pocket [chemical binding]; other site 234621008254 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621008255 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 234621008256 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 234621008257 Walker A/P-loop; other site 234621008258 ATP binding site [chemical binding]; other site 234621008259 Q-loop/lid; other site 234621008260 ABC transporter signature motif; other site 234621008261 Walker B; other site 234621008262 D-loop; other site 234621008263 H-loop/switch region; other site 234621008264 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234621008265 S-adenosylmethionine binding site [chemical binding]; other site 234621008266 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 234621008267 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 234621008268 YhhN-like protein; Region: YhhN; pfam07947 234621008269 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 234621008270 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 234621008271 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 234621008272 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 234621008273 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 234621008274 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 234621008275 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 234621008276 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 234621008277 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 234621008278 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 234621008279 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 234621008280 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 234621008281 4Fe-4S binding domain; Region: Fer4; pfam00037 234621008282 4Fe-4S binding domain; Region: Fer4; pfam00037 234621008283 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 234621008284 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 234621008285 NADH dehydrogenase subunit G; Validated; Region: PRK07860 234621008286 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 234621008287 catalytic loop [active] 234621008288 iron binding site [ion binding]; other site 234621008289 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 234621008290 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 234621008291 molybdopterin cofactor binding site; other site 234621008292 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 234621008293 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 234621008294 SLBB domain; Region: SLBB; pfam10531 234621008295 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 234621008296 NADH dehydrogenase subunit E; Validated; Region: PRK07539 234621008297 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 234621008298 putative dimer interface [polypeptide binding]; other site 234621008299 [2Fe-2S] cluster binding site [ion binding]; other site 234621008300 NADH dehydrogenase subunit D; Validated; Region: PRK06075 234621008301 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 234621008302 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 234621008303 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 234621008304 NADH dehydrogenase subunit B; Validated; Region: PRK06411 234621008305 NADH dehydrogenase subunit A; Validated; Region: PRK07928 234621008306 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 234621008307 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234621008308 active site 234621008309 phosphorylation site [posttranslational modification] 234621008310 intermolecular recognition site; other site 234621008311 dimerization interface [polypeptide binding]; other site 234621008312 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 234621008313 putative hydrophobic ligand binding site [chemical binding]; other site 234621008314 HicB family; Region: HicB; pfam05534 234621008315 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 234621008316 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 234621008317 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 234621008318 dimer interface [polypeptide binding]; other site 234621008319 active site 234621008320 catalytic residue [active] 234621008321 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 234621008322 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 234621008323 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 234621008324 TIGR03085 family protein; Region: TIGR03085 234621008325 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 234621008326 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 234621008327 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 234621008328 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 234621008329 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 234621008330 YCII-related domain; Region: YCII; cl00999 234621008331 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 234621008332 Coenzyme A binding pocket [chemical binding]; other site 234621008333 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 234621008334 Competence-damaged protein; Region: CinA; pfam02464 234621008335 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234621008336 non-specific DNA binding site [nucleotide binding]; other site 234621008337 salt bridge; other site 234621008338 sequence-specific DNA binding site [nucleotide binding]; other site 234621008339 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 234621008340 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 234621008341 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 234621008342 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 234621008343 Walker A/P-loop; other site 234621008344 ATP binding site [chemical binding]; other site 234621008345 Q-loop/lid; other site 234621008346 ABC transporter signature motif; other site 234621008347 Walker B; other site 234621008348 D-loop; other site 234621008349 H-loop/switch region; other site 234621008350 BioY family; Region: BioY; pfam02632 234621008351 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 234621008352 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621008353 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621008354 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 234621008355 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 234621008356 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 234621008357 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 234621008358 recombinase A; Provisional; Region: recA; PRK09354 234621008359 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 234621008360 hexamer interface [polypeptide binding]; other site 234621008361 Walker A motif; other site 234621008362 ATP binding site [chemical binding]; other site 234621008363 Walker B motif; other site 234621008364 recombination regulator RecX; Reviewed; Region: recX; PRK00117 234621008365 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234621008366 dimer interface [polypeptide binding]; other site 234621008367 conserved gate region; other site 234621008368 putative PBP binding loops; other site 234621008369 ABC-ATPase subunit interface; other site 234621008370 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234621008371 dimer interface [polypeptide binding]; other site 234621008372 conserved gate region; other site 234621008373 putative PBP binding loops; other site 234621008374 ABC-ATPase subunit interface; other site 234621008375 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 234621008376 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 234621008377 substrate binding pocket [chemical binding]; other site 234621008378 membrane-bound complex binding site; other site 234621008379 hinge residues; other site 234621008380 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 234621008381 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 234621008382 Walker A/P-loop; other site 234621008383 ATP binding site [chemical binding]; other site 234621008384 Q-loop/lid; other site 234621008385 ABC transporter signature motif; other site 234621008386 Walker B; other site 234621008387 D-loop; other site 234621008388 H-loop/switch region; other site 234621008389 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 234621008390 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 234621008391 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 234621008392 FeS/SAM binding site; other site 234621008393 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 234621008394 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 234621008395 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 234621008396 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 234621008397 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 234621008398 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 234621008399 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 234621008400 active site 234621008401 catalytic site [active] 234621008402 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 234621008403 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 234621008404 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 234621008405 GTPases [General function prediction only]; Region: HflX; COG2262 234621008406 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 234621008407 HflX GTPase family; Region: HflX; cd01878 234621008408 G1 box; other site 234621008409 GTP/Mg2+ binding site [chemical binding]; other site 234621008410 Switch I region; other site 234621008411 G2 box; other site 234621008412 G3 box; other site 234621008413 Switch II region; other site 234621008414 G4 box; other site 234621008415 G5 box; other site 234621008416 Putative esterase; Region: Esterase; pfam00756 234621008417 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 234621008418 dimerization domain swap beta strand [polypeptide binding]; other site 234621008419 regulatory protein interface [polypeptide binding]; other site 234621008420 active site 234621008421 regulatory phosphorylation site [posttranslational modification]; other site 234621008422 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 234621008423 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 234621008424 active site 234621008425 phosphorylation site [posttranslational modification] 234621008426 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 234621008427 active site 234621008428 P-loop; other site 234621008429 phosphorylation site [posttranslational modification] 234621008430 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 234621008431 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 234621008432 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 234621008433 putative substrate binding site [chemical binding]; other site 234621008434 putative ATP binding site [chemical binding]; other site 234621008435 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 234621008436 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 234621008437 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 234621008438 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 234621008439 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 234621008440 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 234621008441 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 234621008442 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 234621008443 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621008444 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621008445 active site 234621008446 LexA repressor; Validated; Region: PRK00215 234621008447 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 234621008448 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 234621008449 Catalytic site [active] 234621008450 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 234621008451 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 234621008452 ATP cone domain; Region: ATP-cone; pfam03477 234621008453 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 234621008454 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 234621008455 ATP binding site [chemical binding]; other site 234621008456 putative Mg++ binding site [ion binding]; other site 234621008457 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 234621008458 nucleotide binding region [chemical binding]; other site 234621008459 ATP-binding site [chemical binding]; other site 234621008460 Helicase associated domain (HA2); Region: HA2; pfam04408 234621008461 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 234621008462 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 234621008463 Uncharacterized protein conserved in bacteria (DUF2322); Region: DUF2322; pfam10084 234621008464 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 234621008465 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 234621008466 inhibitor-cofactor binding pocket; inhibition site 234621008467 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234621008468 catalytic residue [active] 234621008469 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 234621008470 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 234621008471 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 234621008472 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 234621008473 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 234621008474 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 234621008475 dimer interface [polypeptide binding]; other site 234621008476 decamer (pentamer of dimers) interface [polypeptide binding]; other site 234621008477 catalytic triad [active] 234621008478 peroxidatic and resolving cysteines [active] 234621008479 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 234621008480 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 234621008481 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 234621008482 dimerization interface [polypeptide binding]; other site 234621008483 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 234621008484 FAD binding domain; Region: FAD_binding_4; pfam01565 234621008485 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 234621008486 dimerization interface [polypeptide binding]; other site 234621008487 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 234621008488 ATP binding site [chemical binding]; other site 234621008489 putative Mg++ binding site [ion binding]; other site 234621008490 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 234621008491 nucleotide binding region [chemical binding]; other site 234621008492 ATP-binding site [chemical binding]; other site 234621008493 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 234621008494 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 234621008495 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 234621008496 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 234621008497 PAC2 family; Region: PAC2; pfam09754 234621008498 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 234621008499 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 234621008500 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 234621008501 NAD binding site [chemical binding]; other site 234621008502 homodimer interface [polypeptide binding]; other site 234621008503 active site 234621008504 substrate binding site [chemical binding]; other site 234621008505 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 234621008506 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 234621008507 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 234621008508 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 234621008509 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 234621008510 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 234621008511 active site 234621008512 Zn binding site [ion binding]; other site 234621008513 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 234621008514 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 234621008515 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 234621008516 CoA binding domain; Region: CoA_binding_2; pfam13380 234621008517 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 234621008518 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 234621008519 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 234621008520 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 234621008521 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234621008522 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 234621008523 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234621008524 DNA binding residues [nucleotide binding] 234621008525 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 234621008526 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234621008527 S-adenosylmethionine binding site [chemical binding]; other site 234621008528 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 234621008529 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 234621008530 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 234621008531 DNA-binding 11 kDa phosphoprotein; Region: Pox_F17; cl17330 234621008532 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 234621008533 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 234621008534 ATP binding site [chemical binding]; other site 234621008535 putative Mg++ binding site [ion binding]; other site 234621008536 Protein of unknown function (DUF952); Region: DUF952; pfam06108 234621008537 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 234621008538 TrkA-C domain; Region: TrkA_C; pfam02080 234621008539 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 234621008540 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 234621008541 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 234621008542 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 234621008543 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 234621008544 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234621008545 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 234621008546 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234621008547 DNA binding residues [nucleotide binding] 234621008548 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 234621008549 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 234621008550 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 234621008551 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 234621008552 active site 234621008553 dimerization interface [polypeptide binding]; other site 234621008554 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 234621008555 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 234621008556 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 234621008557 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 234621008558 trimer interface [polypeptide binding]; other site 234621008559 active site 234621008560 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 234621008561 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 234621008562 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 234621008563 generic binding surface II; other site 234621008564 ssDNA binding site; other site 234621008565 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 234621008566 Predicted acetyltransferase [General function prediction only]; Region: COG2388 234621008567 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 234621008568 TrkA-N domain; Region: TrkA_N; pfam02254 234621008569 TrkA-C domain; Region: TrkA_C; pfam02080 234621008570 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 234621008571 TrkA-N domain; Region: TrkA_N; pfam02254 234621008572 TrkA-C domain; Region: TrkA_C; pfam02080 234621008573 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 234621008574 TRAM domain; Region: TRAM; pfam01938 234621008575 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 234621008576 Transcriptional regulators [Transcription]; Region: MarR; COG1846 234621008577 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 234621008578 putative Zn2+ binding site [ion binding]; other site 234621008579 putative DNA binding site [nucleotide binding]; other site 234621008580 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 234621008581 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621008582 putative substrate translocation pore; other site 234621008583 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621008584 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 234621008585 glutaminase; Provisional; Region: PRK00971 234621008586 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 234621008587 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 234621008588 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 234621008589 ligand binding site [chemical binding]; other site 234621008590 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 234621008591 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 234621008592 TPP-binding site; other site 234621008593 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 234621008594 PYR/PP interface [polypeptide binding]; other site 234621008595 dimer interface [polypeptide binding]; other site 234621008596 TPP binding site [chemical binding]; other site 234621008597 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 234621008598 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 234621008599 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621008600 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621008601 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 234621008602 hydrophobic ligand binding site; other site 234621008603 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 234621008604 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 234621008605 siderophore binding site; other site 234621008606 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 234621008607 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 234621008608 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 234621008609 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 234621008610 substrate binding site [chemical binding]; other site 234621008611 oxyanion hole (OAH) forming residues; other site 234621008612 trimer interface [polypeptide binding]; other site 234621008613 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 234621008614 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 234621008615 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 234621008616 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 234621008617 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 234621008618 dimer interface [polypeptide binding]; other site 234621008619 active site 234621008620 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 234621008621 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 234621008622 catalytic site [active] 234621008623 putative active site [active] 234621008624 putative substrate binding site [chemical binding]; other site 234621008625 Helicase and RNase D C-terminal; Region: HRDC; smart00341 234621008626 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 234621008627 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 234621008628 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 234621008629 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 234621008630 substrate binding site [chemical binding]; other site 234621008631 active site 234621008632 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 234621008633 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 234621008634 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 234621008635 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 234621008636 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 234621008637 molybdopterin cofactor binding site [chemical binding]; other site 234621008638 substrate binding site [chemical binding]; other site 234621008639 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 234621008640 molybdopterin cofactor binding site; other site 234621008641 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 234621008642 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 234621008643 SelR domain; Region: SelR; pfam01641 234621008644 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 234621008645 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 234621008646 TAP-like protein; Region: Abhydrolase_4; pfam08386 234621008647 hypothetical protein; Provisional; Region: PRK14059 234621008648 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 234621008649 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 234621008650 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 234621008651 Walker A motif; other site 234621008652 ATP binding site [chemical binding]; other site 234621008653 Walker B motif; other site 234621008654 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 234621008655 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 234621008656 Coenzyme A binding pocket [chemical binding]; other site 234621008657 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621008658 putative substrate translocation pore; other site 234621008659 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 234621008660 beta-galactosidase; Region: BGL; TIGR03356 234621008661 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 234621008662 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 234621008663 Fic/DOC family; Region: Fic; pfam02661 234621008664 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 234621008665 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 234621008666 catalytic residues [active] 234621008667 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 234621008668 putative active site [active] 234621008669 multiple promoter invertase; Provisional; Region: mpi; PRK13413 234621008670 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 234621008671 catalytic residues [active] 234621008672 catalytic nucleophile [active] 234621008673 Presynaptic Site I dimer interface [polypeptide binding]; other site 234621008674 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 234621008675 Synaptic Flat tetramer interface [polypeptide binding]; other site 234621008676 Synaptic Site I dimer interface [polypeptide binding]; other site 234621008677 DNA binding site [nucleotide binding] 234621008678 Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337 234621008679 MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and Trafficking molecules) domains, as well as in some bacterial proteins. The function of this domain is unknown; Region: MIT_C; cd02685 234621008680 TIGR02687 family protein; Region: TIGR02687 234621008681 PglZ domain; Region: PglZ; pfam08665 234621008682 Methyltransferase domain; Region: Methyltransf_26; pfam13659 234621008683 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cl00505 234621008684 trimer interface [polypeptide binding]; other site 234621008685 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 234621008686 Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849 234621008687 DNA binding domain, excisionase family; Region: excise; TIGR01764 234621008688 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 234621008689 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 234621008690 active site 234621008691 catalytic residues [active] 234621008692 DNA binding site [nucleotide binding] 234621008693 Int/Topo IB signature motif; other site 234621008694 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 234621008695 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 234621008696 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 234621008697 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 234621008698 active site 234621008699 dimer interface [polypeptide binding]; other site 234621008700 motif 1; other site 234621008701 motif 2; other site 234621008702 motif 3; other site 234621008703 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 234621008704 anticodon binding site; other site 234621008705 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 234621008706 nucleotide binding site/active site [active] 234621008707 HIT family signature motif; other site 234621008708 catalytic residue [active] 234621008709 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 234621008710 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 234621008711 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 234621008712 putative acyl-acceptor binding pocket; other site 234621008713 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 234621008714 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 234621008715 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 234621008716 nudix motif; other site 234621008717 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 234621008718 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 234621008719 active site 234621008720 multimer interface [polypeptide binding]; other site 234621008721 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 234621008722 homotrimer interaction site [polypeptide binding]; other site 234621008723 putative active site [active] 234621008724 Domain of unknown function (DUF222); Region: DUF222; pfam02720 234621008725 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 234621008726 active site 234621008727 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 234621008728 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 234621008729 active site 234621008730 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 234621008731 catalytic triad [active] 234621008732 dimer interface [polypeptide binding]; other site 234621008733 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 234621008734 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 234621008735 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 234621008736 active site 234621008737 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 234621008738 catalytic triad [active] 234621008739 dimer interface [polypeptide binding]; other site 234621008740 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 234621008741 imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; Region: IMP_synth_hisH; TIGR01855 234621008742 predicted active site [active] 234621008743 catalytic triad [active] 234621008744 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 234621008745 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234621008746 active site 234621008747 phosphorylation site [posttranslational modification] 234621008748 intermolecular recognition site; other site 234621008749 dimerization interface [polypeptide binding]; other site 234621008750 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 234621008751 DNA binding residues [nucleotide binding] 234621008752 dimerization interface [polypeptide binding]; other site 234621008753 Histidine kinase; Region: HisKA_3; pfam07730 234621008754 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234621008755 ATP binding site [chemical binding]; other site 234621008756 Mg2+ binding site [ion binding]; other site 234621008757 G-X-G motif; other site 234621008758 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 234621008759 Predicted transcriptional regulators [Transcription]; Region: COG1725 234621008760 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 234621008761 DNA-binding site [nucleotide binding]; DNA binding site 234621008762 hypothetical protein; Validated; Region: PRK00110 234621008763 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 234621008764 active site 234621008765 putative DNA-binding cleft [nucleotide binding]; other site 234621008766 dimer interface [polypeptide binding]; other site 234621008767 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 234621008768 RuvA N terminal domain; Region: RuvA_N; pfam01330 234621008769 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 234621008770 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 234621008771 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234621008772 Walker A motif; other site 234621008773 ATP binding site [chemical binding]; other site 234621008774 Walker B motif; other site 234621008775 arginine finger; other site 234621008776 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 234621008777 Preprotein translocase subunit; Region: YajC; cl00806 234621008778 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 234621008779 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 234621008780 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 234621008781 Protein export membrane protein; Region: SecD_SecF; pfam02355 234621008782 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 234621008783 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 234621008784 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 234621008785 active site 234621008786 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 234621008787 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 234621008788 Zn2+ binding site [ion binding]; other site 234621008789 Mg2+ binding site [ion binding]; other site 234621008790 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 234621008791 synthetase active site [active] 234621008792 NTP binding site [chemical binding]; other site 234621008793 metal binding site [ion binding]; metal-binding site 234621008794 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 234621008795 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 234621008796 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 234621008797 active site 234621008798 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 234621008799 active site 234621008800 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 234621008801 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 234621008802 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 234621008803 dimer interface [polypeptide binding]; other site 234621008804 motif 1; other site 234621008805 active site 234621008806 motif 2; other site 234621008807 motif 3; other site 234621008808 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 234621008809 anticodon binding site; other site 234621008810 malate dehydrogenase; Provisional; Region: PRK05442 234621008811 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 234621008812 NAD(P) binding site [chemical binding]; other site 234621008813 dimer interface [polypeptide binding]; other site 234621008814 malate binding site [chemical binding]; other site 234621008815 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 234621008816 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 234621008817 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 234621008818 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 234621008819 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 234621008820 catalytic site [active] 234621008821 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 234621008822 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 234621008823 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 234621008824 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 234621008825 Walker A/P-loop; other site 234621008826 ATP binding site [chemical binding]; other site 234621008827 Q-loop/lid; other site 234621008828 ABC transporter signature motif; other site 234621008829 Walker B; other site 234621008830 D-loop; other site 234621008831 H-loop/switch region; other site 234621008832 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 234621008833 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 234621008834 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621008835 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 234621008836 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 234621008837 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 234621008838 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234621008839 Walker A/P-loop; other site 234621008840 ATP binding site [chemical binding]; other site 234621008841 Q-loop/lid; other site 234621008842 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 234621008843 ABC transporter signature motif; other site 234621008844 Walker B; other site 234621008845 D-loop; other site 234621008846 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 234621008847 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 234621008848 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 234621008849 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 234621008850 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621008851 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621008852 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 234621008853 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 234621008854 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 234621008855 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 234621008856 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 234621008857 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 234621008858 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 234621008859 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 234621008860 Fic/DOC family; Region: Fic; cl00960 234621008861 FOG: CBS domain [General function prediction only]; Region: COG0517 234621008862 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 234621008863 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 234621008864 metal binding triad; other site 234621008865 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 234621008866 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 234621008867 homotrimer interaction site [polypeptide binding]; other site 234621008868 putative active site [active] 234621008869 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 234621008870 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 234621008871 FeS/SAM binding site; other site 234621008872 3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074 234621008873 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 234621008874 Methyltransferase domain; Region: Methyltransf_12; pfam08242 234621008875 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 234621008876 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 234621008877 active site 234621008878 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 234621008879 active site 234621008880 metal binding site [ion binding]; metal-binding site 234621008881 Methyltransferase domain; Region: Methyltransf_23; pfam13489 234621008882 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234621008883 S-adenosylmethionine binding site [chemical binding]; other site 234621008884 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 234621008885 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621008886 putative substrate translocation pore; other site 234621008887 Transcriptional regulators [Transcription]; Region: PurR; COG1609 234621008888 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 234621008889 DNA binding site [nucleotide binding] 234621008890 domain linker motif; other site 234621008891 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 234621008892 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 234621008893 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 234621008894 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 234621008895 Cupin domain; Region: Cupin_2; cl17218 234621008896 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 234621008897 Zn2+ binding site [ion binding]; other site 234621008898 Mg2+ binding site [ion binding]; other site 234621008899 Uncharacterized protein conserved in bacteria (DUF2272); Region: DUF2272; cl01776 234621008900 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621008901 Major Facilitator Superfamily; Region: MFS_1; pfam07690 234621008902 putative substrate translocation pore; other site 234621008903 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621008904 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621008905 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 234621008906 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 234621008907 PhnA protein; Region: PhnA; pfam03831 234621008908 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 234621008909 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 234621008910 intersubunit interface [polypeptide binding]; other site 234621008911 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 234621008912 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 234621008913 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 234621008914 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 234621008915 hydrophobic ligand binding site; other site 234621008916 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 234621008917 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 234621008918 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 234621008919 dimer interface [polypeptide binding]; other site 234621008920 anticodon binding site; other site 234621008921 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 234621008922 homodimer interface [polypeptide binding]; other site 234621008923 motif 1; other site 234621008924 active site 234621008925 motif 2; other site 234621008926 GAD domain; Region: GAD; pfam02938 234621008927 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 234621008928 active site 234621008929 motif 3; other site 234621008930 Domain of unknown function (DUF389); Region: DUF389; cl00781 234621008931 Domain of unknown function (DUF389); Region: DUF389; cl00781 234621008932 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 234621008933 substrate binding site [chemical binding]; other site 234621008934 SnoaL-like domain; Region: SnoaL_2; pfam12680 234621008935 recombination factor protein RarA; Reviewed; Region: PRK13342 234621008936 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234621008937 Walker A motif; other site 234621008938 ATP binding site [chemical binding]; other site 234621008939 Walker B motif; other site 234621008940 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 234621008941 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 234621008942 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 234621008943 motif 1; other site 234621008944 active site 234621008945 motif 2; other site 234621008946 motif 3; other site 234621008947 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 234621008948 DHHA1 domain; Region: DHHA1; pfam02272 234621008949 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 234621008950 YceG-like family; Region: YceG; pfam02618 234621008951 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 234621008952 dimerization interface [polypeptide binding]; other site 234621008953 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 234621008954 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 234621008955 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 234621008956 shikimate binding site; other site 234621008957 NAD(P) binding site [chemical binding]; other site 234621008958 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 234621008959 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 234621008960 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 234621008961 substrate binding sites [chemical binding]; other site 234621008962 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 234621008963 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 234621008964 Tetramer interface [polypeptide binding]; other site 234621008965 active site 234621008966 FMN-binding site [chemical binding]; other site 234621008967 shikimate kinase; Reviewed; Region: aroK; PRK00131 234621008968 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 234621008969 ADP binding site [chemical binding]; other site 234621008970 magnesium binding site [ion binding]; other site 234621008971 putative shikimate binding site; other site 234621008972 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 234621008973 active site 234621008974 dimer interface [polypeptide binding]; other site 234621008975 metal binding site [ion binding]; metal-binding site 234621008976 Dehydroquinase class II; Region: DHquinase_II; pfam01220 234621008977 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 234621008978 trimer interface [polypeptide binding]; other site 234621008979 active site 234621008980 dimer interface [polypeptide binding]; other site 234621008981 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 234621008982 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 234621008983 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 234621008984 active site 234621008985 elongation factor P; Validated; Region: PRK00529 234621008986 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 234621008987 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 234621008988 RNA binding site [nucleotide binding]; other site 234621008989 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 234621008990 RNA binding site [nucleotide binding]; other site 234621008991 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 234621008992 putative RNA binding site [nucleotide binding]; other site 234621008993 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 234621008994 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 234621008995 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 234621008996 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 234621008997 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 234621008998 dihydroorotase; Validated; Region: pyrC; PRK09357 234621008999 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234621009000 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 234621009001 active site 234621009002 Domain of unknown function (DUF4329); Region: DUF4329; pfam14220 234621009003 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 234621009004 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 234621009005 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 234621009006 catalytic site [active] 234621009007 subunit interface [polypeptide binding]; other site 234621009008 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 234621009009 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 234621009010 ATP-grasp domain; Region: ATP-grasp_4; cl17255 234621009011 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 234621009012 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 234621009013 ATP-grasp domain; Region: ATP-grasp_4; cl17255 234621009014 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 234621009015 IMP binding site; other site 234621009016 dimer interface [polypeptide binding]; other site 234621009017 interdomain contacts; other site 234621009018 partial ornithine binding site; other site 234621009019 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 234621009020 active site 234621009021 dimer interface [polypeptide binding]; other site 234621009022 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 234621009023 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 234621009024 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 234621009025 catalytic site [active] 234621009026 G-X2-G-X-G-K; other site 234621009027 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 234621009028 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 234621009029 Flavoprotein; Region: Flavoprotein; pfam02441 234621009030 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 234621009031 S-adenosylmethionine synthetase; Validated; Region: PRK05250 234621009032 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 234621009033 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 234621009034 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 234621009035 primosome assembly protein PriA; Provisional; Region: PRK14873 234621009036 Predicted transcriptional regulators [Transcription]; Region: COG1695 234621009037 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 234621009038 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 234621009039 Lipase (class 2); Region: Lipase_2; pfam01674 234621009040 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 234621009041 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 234621009042 putative active site [active] 234621009043 substrate binding site [chemical binding]; other site 234621009044 putative cosubstrate binding site; other site 234621009045 catalytic site [active] 234621009046 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 234621009047 substrate binding site [chemical binding]; other site 234621009048 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 234621009049 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 234621009050 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 234621009051 Protein of unknown function (DUF419); Region: DUF419; cl15265 234621009052 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 234621009053 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 234621009054 substrate binding site [chemical binding]; other site 234621009055 hexamer interface [polypeptide binding]; other site 234621009056 metal binding site [ion binding]; metal-binding site 234621009057 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 234621009058 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 234621009059 catalytic motif [active] 234621009060 Zn binding site [ion binding]; other site 234621009061 RibD C-terminal domain; Region: RibD_C; pfam01872 234621009062 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 234621009063 Lumazine binding domain; Region: Lum_binding; pfam00677 234621009064 Lumazine binding domain; Region: Lum_binding; pfam00677 234621009065 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 234621009066 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 234621009067 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 234621009068 dimerization interface [polypeptide binding]; other site 234621009069 active site 234621009070 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 234621009071 homopentamer interface [polypeptide binding]; other site 234621009072 active site 234621009073 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 234621009074 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 234621009075 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 234621009076 GIY-YIG motif/motif A; other site 234621009077 active site 234621009078 catalytic site [active] 234621009079 putative DNA binding site [nucleotide binding]; other site 234621009080 metal binding site [ion binding]; metal-binding site 234621009081 UvrB/uvrC motif; Region: UVR; pfam02151 234621009082 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 234621009083 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 234621009084 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 234621009085 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 234621009086 phosphate binding site [ion binding]; other site 234621009087 putative substrate binding pocket [chemical binding]; other site 234621009088 dimer interface [polypeptide binding]; other site 234621009089 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 234621009090 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 234621009091 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 234621009092 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 234621009093 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 234621009094 Phosphoglycerate kinase; Region: PGK; pfam00162 234621009095 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 234621009096 substrate binding site [chemical binding]; other site 234621009097 hinge regions; other site 234621009098 ADP binding site [chemical binding]; other site 234621009099 catalytic site [active] 234621009100 triosephosphate isomerase; Provisional; Region: PRK14567 234621009101 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 234621009102 substrate binding site [chemical binding]; other site 234621009103 dimer interface [polypeptide binding]; other site 234621009104 catalytic triad [active] 234621009105 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 234621009106 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 234621009107 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 234621009108 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 234621009109 short chain dehydrogenase; Provisional; Region: PRK06523 234621009110 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621009111 NAD(P) binding site [chemical binding]; other site 234621009112 active site 234621009113 Protein of unknown function (DUF419); Region: DUF419; cl15265 234621009114 Predicted ATPase [General function prediction only]; Region: COG3910 234621009115 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234621009116 Walker A/P-loop; other site 234621009117 ATP binding site [chemical binding]; other site 234621009118 Q-loop/lid; other site 234621009119 ABC transporter signature motif; other site 234621009120 Walker B; other site 234621009121 D-loop; other site 234621009122 H-loop/switch region; other site 234621009123 Domain of unknown function (DU1801); Region: DUF1801; cl17490 234621009124 short chain dehydrogenase; Provisional; Region: PRK08303 234621009125 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621009126 NAD(P) binding site [chemical binding]; other site 234621009127 active site 234621009128 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 234621009129 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 234621009130 putative active site [active] 234621009131 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 234621009132 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 234621009133 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 234621009134 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 234621009135 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 234621009136 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 234621009137 putative active site [active] 234621009138 catalytic residue [active] 234621009139 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 234621009140 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 234621009141 TPP-binding site [chemical binding]; other site 234621009142 dimer interface [polypeptide binding]; other site 234621009143 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 234621009144 PYR/PP interface [polypeptide binding]; other site 234621009145 dimer interface [polypeptide binding]; other site 234621009146 TPP binding site [chemical binding]; other site 234621009147 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 234621009148 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 234621009149 UbiA prenyltransferase family; Region: UbiA; pfam01040 234621009150 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 234621009151 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 234621009152 NADP binding site [chemical binding]; other site 234621009153 dimer interface [polypeptide binding]; other site 234621009154 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 234621009155 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 234621009156 ABC-2 type transporter; Region: ABC2_membrane; cl17235 234621009157 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 234621009158 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 234621009159 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 234621009160 Walker A/P-loop; other site 234621009161 ATP binding site [chemical binding]; other site 234621009162 Q-loop/lid; other site 234621009163 ABC transporter signature motif; other site 234621009164 Walker B; other site 234621009165 D-loop; other site 234621009166 H-loop/switch region; other site 234621009167 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 234621009168 Predicted transcriptional regulator [Transcription]; Region: COG2345 234621009169 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 234621009170 putative DNA binding site [nucleotide binding]; other site 234621009171 putative Zn2+ binding site [ion binding]; other site 234621009172 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 234621009173 FeS assembly protein SufB; Region: sufB; TIGR01980 234621009174 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 234621009175 FeS assembly protein SufD; Region: sufD; TIGR01981 234621009176 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 234621009177 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 234621009178 Walker A/P-loop; other site 234621009179 ATP binding site [chemical binding]; other site 234621009180 Q-loop/lid; other site 234621009181 ABC transporter signature motif; other site 234621009182 Walker B; other site 234621009183 D-loop; other site 234621009184 H-loop/switch region; other site 234621009185 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 234621009186 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 234621009187 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 234621009188 catalytic residue [active] 234621009189 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 234621009190 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 234621009191 trimerization site [polypeptide binding]; other site 234621009192 active site 234621009193 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 234621009194 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 234621009195 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 234621009196 acyl-activating enzyme (AAE) consensus motif; other site 234621009197 AMP binding site [chemical binding]; other site 234621009198 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 234621009199 Condensation domain; Region: Condensation; pfam00668 234621009200 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 234621009201 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 234621009202 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 234621009203 acyl-activating enzyme (AAE) consensus motif; other site 234621009204 AMP binding site [chemical binding]; other site 234621009205 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 234621009206 Condensation domain; Region: Condensation; pfam00668 234621009207 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 234621009208 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 234621009209 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 234621009210 acyl-activating enzyme (AAE) consensus motif; other site 234621009211 AMP binding site [chemical binding]; other site 234621009212 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 234621009213 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 234621009214 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 234621009215 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 234621009216 acyl-activating enzyme (AAE) consensus motif; other site 234621009217 AMP binding site [chemical binding]; other site 234621009218 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 234621009219 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 234621009220 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 234621009221 putative DNA binding site [nucleotide binding]; other site 234621009222 putative homodimer interface [polypeptide binding]; other site 234621009223 Putative esterase; Region: Esterase; pfam00756 234621009224 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 234621009225 lycopene cyclase; Region: lycopene_cycl; TIGR01789 234621009226 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 234621009227 classical (c) SDRs; Region: SDR_c; cd05233 234621009228 NAD(P) binding site [chemical binding]; other site 234621009229 active site 234621009230 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 234621009231 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234621009232 Walker A/P-loop; other site 234621009233 ATP binding site [chemical binding]; other site 234621009234 Q-loop/lid; other site 234621009235 ABC transporter signature motif; other site 234621009236 Walker B; other site 234621009237 D-loop; other site 234621009238 H-loop/switch region; other site 234621009239 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 234621009240 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621009241 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621009242 aconitate hydratase; Validated; Region: PRK09277 234621009243 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 234621009244 substrate binding site [chemical binding]; other site 234621009245 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 234621009246 ligand binding site [chemical binding]; other site 234621009247 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 234621009248 substrate binding site [chemical binding]; other site 234621009249 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 234621009250 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 234621009251 NlpC/P60 family; Region: NLPC_P60; pfam00877 234621009252 MoxR-like ATPases [General function prediction only]; Region: COG0714 234621009253 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234621009254 Walker A motif; other site 234621009255 ATP binding site [chemical binding]; other site 234621009256 Walker B motif; other site 234621009257 arginine finger; other site 234621009258 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 234621009259 Protein of unknown function DUF58; Region: DUF58; pfam01882 234621009260 hypothetical protein; Provisional; Region: PRK13685 234621009261 von Willebrand factor type A domain; Region: VWA_2; pfam13519 234621009262 metal ion-dependent adhesion site (MIDAS); other site 234621009263 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 234621009264 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 234621009265 NAD(P) binding site [chemical binding]; other site 234621009266 homotetramer interface [polypeptide binding]; other site 234621009267 homodimer interface [polypeptide binding]; other site 234621009268 active site 234621009269 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 234621009270 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621009271 NAD(P) binding site [chemical binding]; other site 234621009272 active site 234621009273 ferrochelatase; Reviewed; Region: hemH; PRK00035 234621009274 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 234621009275 C-terminal domain interface [polypeptide binding]; other site 234621009276 active site 234621009277 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 234621009278 active site 234621009279 N-terminal domain interface [polypeptide binding]; other site 234621009280 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 234621009281 HypX protein, N-terminal hydrolase domain; Region: FMT_core_HypX_N; cd08650 234621009282 putative active site [active] 234621009283 putative substrate binding site [chemical binding]; other site 234621009284 putative cosubstrate binding site; other site 234621009285 catalytic site [active] 234621009286 C-terminal subdomain of the Formyltransferase-like domain found in HypX-like proteins; Region: FMT_C_HypX; cd08701 234621009287 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 234621009288 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 234621009289 substrate binding site [chemical binding]; other site 234621009290 oxyanion hole (OAH) forming residues; other site 234621009291 trimer interface [polypeptide binding]; other site 234621009292 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 234621009293 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 234621009294 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 234621009295 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 234621009296 Uncharacterized conserved protein [Function unknown]; Region: COG0398 234621009297 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 234621009298 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 234621009299 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 234621009300 heterodimer interface [polypeptide binding]; other site 234621009301 substrate interaction site [chemical binding]; other site 234621009302 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 234621009303 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 234621009304 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 234621009305 active site 234621009306 substrate binding site [chemical binding]; other site 234621009307 coenzyme B12 binding site [chemical binding]; other site 234621009308 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 234621009309 B12 binding site [chemical binding]; other site 234621009310 cobalt ligand [ion binding]; other site 234621009311 membrane ATPase/protein kinase; Provisional; Region: PRK09435 234621009312 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 234621009313 Walker A; other site 234621009314 Predicted permeases [General function prediction only]; Region: COG0730 234621009315 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 234621009316 active site 234621009317 OsmC-like protein; Region: OsmC; cl00767 234621009318 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 234621009319 CoA-transferase family III; Region: CoA_transf_3; pfam02515 234621009320 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 234621009321 Domain of unknown function DUF21; Region: DUF21; pfam01595 234621009322 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 234621009323 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 234621009324 Domain of unknown function DUF21; Region: DUF21; pfam01595 234621009325 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 234621009326 Transporter associated domain; Region: CorC_HlyC; smart01091 234621009327 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 234621009328 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 234621009329 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 234621009330 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 234621009331 active site 234621009332 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 234621009333 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 234621009334 ATP binding site [chemical binding]; other site 234621009335 Mg++ binding site [ion binding]; other site 234621009336 motif III; other site 234621009337 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 234621009338 nucleotide binding region [chemical binding]; other site 234621009339 ATP-binding site [chemical binding]; other site 234621009340 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 234621009341 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 234621009342 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 234621009343 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 234621009344 DEAD-like helicases superfamily; Region: DEXDc; smart00487 234621009345 ATP binding site [chemical binding]; other site 234621009346 Mg++ binding site [ion binding]; other site 234621009347 motif III; other site 234621009348 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 234621009349 nucleotide binding region [chemical binding]; other site 234621009350 ATP-binding site [chemical binding]; other site 234621009351 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 234621009352 Predicted transcriptional regulator [Transcription]; Region: COG3682 234621009353 Rhomboid family; Region: Rhomboid; cl11446 234621009354 Uncharacterized conserved protein [Function unknown]; Region: COG2898 234621009355 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 234621009356 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 234621009357 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 234621009358 Walker A/P-loop; other site 234621009359 ATP binding site [chemical binding]; other site 234621009360 Q-loop/lid; other site 234621009361 ABC transporter signature motif; other site 234621009362 Walker B; other site 234621009363 D-loop; other site 234621009364 H-loop/switch region; other site 234621009365 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 234621009366 ABC-ATPase subunit interface; other site 234621009367 dimer interface [polypeptide binding]; other site 234621009368 putative PBP binding regions; other site 234621009369 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 234621009370 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 234621009371 ABC-ATPase subunit interface; other site 234621009372 dimer interface [polypeptide binding]; other site 234621009373 putative PBP binding regions; other site 234621009374 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 234621009375 CoenzymeA binding site [chemical binding]; other site 234621009376 subunit interaction site [polypeptide binding]; other site 234621009377 PHB binding site; other site 234621009378 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 234621009379 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 234621009380 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 234621009381 dimerization interface [polypeptide binding]; other site 234621009382 putative DNA binding site [nucleotide binding]; other site 234621009383 putative Zn2+ binding site [ion binding]; other site 234621009384 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 234621009385 putative hydrophobic ligand binding site [chemical binding]; other site 234621009386 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 234621009387 active site 234621009388 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 234621009389 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 234621009390 HprK-related kinase A; Region: HprK_rel_A; TIGR04352 234621009391 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 234621009392 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621009393 NAD(P) binding site [chemical binding]; other site 234621009394 active site 234621009395 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 234621009396 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 234621009397 metal binding site [ion binding]; metal-binding site 234621009398 active site 234621009399 I-site; other site 234621009400 Secretory lipase; Region: LIP; pfam03583 234621009401 Condensation domain; Region: Condensation; pfam00668 234621009402 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 234621009403 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 234621009404 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 234621009405 acyl-activating enzyme (AAE) consensus motif; other site 234621009406 AMP binding site [chemical binding]; other site 234621009407 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 234621009408 Condensation domain; Region: Condensation; pfam00668 234621009409 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 234621009410 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 234621009411 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 234621009412 acyl-activating enzyme (AAE) consensus motif; other site 234621009413 AMP binding site [chemical binding]; other site 234621009414 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 234621009415 peptide synthase; Provisional; Region: PRK12316 234621009416 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 234621009417 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 234621009418 acyl-activating enzyme (AAE) consensus motif; other site 234621009419 AMP binding site [chemical binding]; other site 234621009420 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 234621009421 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 234621009422 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 234621009423 acyl-activating enzyme (AAE) consensus motif; other site 234621009424 AMP binding site [chemical binding]; other site 234621009425 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 234621009426 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 234621009427 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 234621009428 acyl-activating enzyme (AAE) consensus motif; other site 234621009429 AMP binding site [chemical binding]; other site 234621009430 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 234621009431 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 234621009432 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 234621009433 acyl-activating enzyme (AAE) consensus motif; other site 234621009434 AMP binding site [chemical binding]; other site 234621009435 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 234621009436 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 234621009437 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 234621009438 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 234621009439 acyl-activating enzyme (AAE) consensus motif; other site 234621009440 AMP binding site [chemical binding]; other site 234621009441 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 234621009442 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 234621009443 Protease prsW family; Region: PrsW-protease; pfam13367 234621009444 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 234621009445 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 234621009446 putative active site [active] 234621009447 catalytic triad [active] 234621009448 putative dimer interface [polypeptide binding]; other site 234621009449 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 234621009450 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 234621009451 active site 234621009452 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 234621009453 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 234621009454 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234621009455 active site 234621009456 phosphorylation site [posttranslational modification] 234621009457 intermolecular recognition site; other site 234621009458 dimerization interface [polypeptide binding]; other site 234621009459 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 234621009460 DNA binding residues [nucleotide binding] 234621009461 dimerization interface [polypeptide binding]; other site 234621009462 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 234621009463 Histidine kinase; Region: HisKA_3; pfam07730 234621009464 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234621009465 ATP binding site [chemical binding]; other site 234621009466 Mg2+ binding site [ion binding]; other site 234621009467 G-X-G motif; other site 234621009468 hypothetical protein; Provisional; Region: PRK10621 234621009469 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 234621009470 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 234621009471 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 234621009472 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621009473 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 234621009474 NAD(P) binding site [chemical binding]; other site 234621009475 active site 234621009476 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 234621009477 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 234621009478 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 234621009479 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 234621009480 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 234621009481 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 234621009482 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 234621009483 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 234621009484 precorrin-3B synthase; Region: CobG; TIGR02435 234621009485 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 234621009486 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 234621009487 Precorrin-8X methylmutase; Region: CbiC; pfam02570 234621009488 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 234621009489 active site 234621009490 SAM binding site [chemical binding]; other site 234621009491 homodimer interface [polypeptide binding]; other site 234621009492 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 234621009493 active site 234621009494 SAM binding site [chemical binding]; other site 234621009495 homodimer interface [polypeptide binding]; other site 234621009496 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 234621009497 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 234621009498 active site 234621009499 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 234621009500 HicB family; Region: HicB; pfam05534 234621009501 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 234621009502 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 234621009503 RibD C-terminal domain; Region: RibD_C; cl17279 234621009504 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 234621009505 putative DNA binding site [nucleotide binding]; other site 234621009506 putative Zn2+ binding site [ion binding]; other site 234621009507 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 234621009508 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 234621009509 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234621009510 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238 234621009511 dimer interface [polypeptide binding]; other site 234621009512 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621009513 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621009514 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 234621009515 dimerization interface [polypeptide binding]; other site 234621009516 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 234621009517 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 234621009518 active site 234621009519 SAM binding site [chemical binding]; other site 234621009520 homodimer interface [polypeptide binding]; other site 234621009521 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 234621009522 active site 234621009523 putative homodimer interface [polypeptide binding]; other site 234621009524 SAM binding site [chemical binding]; other site 234621009525 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 234621009526 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234621009527 S-adenosylmethionine binding site [chemical binding]; other site 234621009528 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621009529 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 234621009530 NAD(P) binding site [chemical binding]; other site 234621009531 active site 234621009532 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 234621009533 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 234621009534 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 234621009535 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 234621009536 active site 234621009537 5'-3' exonuclease; Region: 53EXOc; smart00475 234621009538 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 234621009539 active site 234621009540 metal binding site 1 [ion binding]; metal-binding site 234621009541 putative 5' ssDNA interaction site; other site 234621009542 metal binding site 3; metal-binding site 234621009543 metal binding site 2 [ion binding]; metal-binding site 234621009544 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 234621009545 putative DNA binding site [nucleotide binding]; other site 234621009546 putative metal binding site [ion binding]; other site 234621009547 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 234621009548 DEAD-like helicases superfamily; Region: DEXDc; smart00487 234621009549 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 234621009550 ATP binding site [chemical binding]; other site 234621009551 putative Mg++ binding site [ion binding]; other site 234621009552 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 234621009553 nucleotide binding region [chemical binding]; other site 234621009554 ATP-binding site [chemical binding]; other site 234621009555 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 234621009556 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 234621009557 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 234621009558 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 234621009559 Predicted transcriptional regulator [Transcription]; Region: COG2378 234621009560 WYL domain; Region: WYL; pfam13280 234621009561 Predicted transcriptional regulator [Transcription]; Region: COG2378 234621009562 WYL domain; Region: WYL; pfam13280 234621009563 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 234621009564 Diacylglycerol kinase catalytic domain (presumed); Region: DAGKc; smart00046 234621009565 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 234621009566 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 234621009567 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 234621009568 active site 234621009569 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 234621009570 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 234621009571 active site 234621009572 Pup-like protein; Region: Pup; cl05289 234621009573 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 234621009574 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 234621009575 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 234621009576 nudix motif; other site 234621009577 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 234621009578 Predicted coiled-coil domain-containing protein; Region: KLRAQ; pfam10205 234621009579 proteasome ATPase; Region: pup_AAA; TIGR03689 234621009580 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234621009581 Walker A motif; other site 234621009582 ATP binding site [chemical binding]; other site 234621009583 Walker B motif; other site 234621009584 arginine finger; other site 234621009585 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 234621009586 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234621009587 S-adenosylmethionine binding site [chemical binding]; other site 234621009588 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 234621009589 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 234621009590 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 234621009591 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 234621009592 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 234621009593 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 234621009594 homodimer interface [polypeptide binding]; other site 234621009595 putative metal binding site [ion binding]; other site 234621009596 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 234621009597 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 234621009598 active site 234621009599 hypothetical protein; Validated; Region: PRK01415 234621009600 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 234621009601 active site residue [active] 234621009602 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 234621009603 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 234621009604 motif II; other site 234621009605 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 234621009606 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 234621009607 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 234621009608 substrate binding pocket [chemical binding]; other site 234621009609 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 234621009610 B12 binding site [chemical binding]; other site 234621009611 cobalt ligand [ion binding]; other site 234621009612 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 234621009613 PAC2 family; Region: PAC2; pfam09754 234621009614 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 234621009615 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621009616 putative substrate translocation pore; other site 234621009617 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 234621009618 TIGR02677 family protein; Region: TIGR02677 234621009619 Protein of unknown function (DUF2398); Region: DUF2398; cl09875 234621009620 TIGR02680 family protein; Region: TIGR02680 234621009621 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 234621009622 cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Region: mycothiol_MshC; TIGR03447 234621009623 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 234621009624 active site 234621009625 HIGH motif; other site 234621009626 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 234621009627 active site 234621009628 KMSKS motif; other site 234621009629 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 234621009630 putative tRNA binding surface [nucleotide binding]; other site 234621009631 MMPL family; Region: MMPL; pfam03176 234621009632 Transcriptional regulators [Transcription]; Region: MarR; COG1846 234621009633 MarR family; Region: MarR_2; pfam12802 234621009634 conserved hypothetical protein; Region: TIGR03843 234621009635 conserved hypothetical protein; Region: TIGR03847 234621009636 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 234621009637 catalytic core [active] 234621009638 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 234621009639 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 234621009640 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 234621009641 active site 234621009642 catalytic tetrad [active] 234621009643 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 234621009644 heme binding pocket [chemical binding]; other site 234621009645 heme ligand [chemical binding]; other site 234621009646 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 234621009647 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 234621009648 intersubunit interface [polypeptide binding]; other site 234621009649 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 234621009650 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 234621009651 ABC-ATPase subunit interface; other site 234621009652 dimer interface [polypeptide binding]; other site 234621009653 putative PBP binding regions; other site 234621009654 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 234621009655 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 234621009656 Walker A/P-loop; other site 234621009657 ATP binding site [chemical binding]; other site 234621009658 Q-loop/lid; other site 234621009659 ABC transporter signature motif; other site 234621009660 Walker B; other site 234621009661 D-loop; other site 234621009662 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 234621009663 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 234621009664 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 234621009665 quinone interaction residues [chemical binding]; other site 234621009666 active site 234621009667 catalytic residues [active] 234621009668 FMN binding site [chemical binding]; other site 234621009669 substrate binding site [chemical binding]; other site 234621009670 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 234621009671 substrate binding site [chemical binding]; other site 234621009672 hypothetical protein; Provisional; Region: PRK07906 234621009673 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 234621009674 putative metal binding site [ion binding]; other site 234621009675 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621009676 NAD(P) binding site [chemical binding]; other site 234621009677 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 234621009678 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621009679 active site 234621009680 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 234621009681 Uncharacterized conserved protein [Function unknown]; Region: COG3268 234621009682 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 234621009683 active site 234621009684 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 234621009685 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 234621009686 metal ion-dependent adhesion site (MIDAS); other site 234621009687 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 234621009688 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 234621009689 putative active site [active] 234621009690 putative metal binding site [ion binding]; other site 234621009691 glycine dehydrogenase; Provisional; Region: PRK05367 234621009692 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 234621009693 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 234621009694 catalytic residue [active] 234621009695 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 234621009696 tetramer interface [polypeptide binding]; other site 234621009697 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234621009698 catalytic residue [active] 234621009699 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 234621009700 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 234621009701 DNA binding residues [nucleotide binding] 234621009702 putative dimer interface [polypeptide binding]; other site 234621009703 Bifunctional nuclease; Region: DNase-RNase; pfam02577 234621009704 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 234621009705 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 234621009706 DNA binding residues [nucleotide binding] 234621009707 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 234621009708 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 234621009709 phosphopeptide binding site; other site 234621009710 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 234621009711 lipoyl attachment site [posttranslational modification]; other site 234621009712 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 234621009713 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 234621009714 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 234621009715 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 234621009716 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 234621009717 putative active site [active] 234621009718 putative CoA binding site [chemical binding]; other site 234621009719 nudix motif; other site 234621009720 metal binding site [ion binding]; metal-binding site 234621009721 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 234621009722 Predicted membrane protein [Function unknown]; Region: COG4325 234621009723 Putative esterase; Region: Esterase; pfam00756 234621009724 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 234621009725 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 234621009726 Zn binding site [ion binding]; other site 234621009727 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 234621009728 substrate binding site [chemical binding]; other site 234621009729 dimer interface [polypeptide binding]; other site 234621009730 ATP binding site [chemical binding]; other site 234621009731 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 234621009732 active site 234621009733 putative catalytic site [active] 234621009734 alternate signal-mediated exported protein, RER_14450 family; Region: exp_by_SipW_III; TIGR04089 234621009735 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 234621009736 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 234621009737 putative active site [active] 234621009738 putative dimer interface [polypeptide binding]; other site 234621009739 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216 234621009740 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 234621009741 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 234621009742 Walker A/P-loop; other site 234621009743 ATP binding site [chemical binding]; other site 234621009744 Q-loop/lid; other site 234621009745 ABC transporter signature motif; other site 234621009746 Walker B; other site 234621009747 D-loop; other site 234621009748 H-loop/switch region; other site 234621009749 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 234621009750 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 234621009751 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 234621009752 Walker A/P-loop; other site 234621009753 ATP binding site [chemical binding]; other site 234621009754 Q-loop/lid; other site 234621009755 ABC transporter signature motif; other site 234621009756 Walker B; other site 234621009757 D-loop; other site 234621009758 H-loop/switch region; other site 234621009759 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 234621009760 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_9; cd08496 234621009761 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 234621009762 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 234621009763 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234621009764 dimer interface [polypeptide binding]; other site 234621009765 conserved gate region; other site 234621009766 putative PBP binding loops; other site 234621009767 ABC-ATPase subunit interface; other site 234621009768 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 234621009769 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234621009770 dimer interface [polypeptide binding]; other site 234621009771 conserved gate region; other site 234621009772 ABC-ATPase subunit interface; other site 234621009773 GTP-binding protein Der; Reviewed; Region: PRK03003 234621009774 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 234621009775 GTP/Mg2+ binding site [chemical binding]; other site 234621009776 G5 box; other site 234621009777 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 234621009778 G1 box; other site 234621009779 G1 box; other site 234621009780 GTP/Mg2+ binding site [chemical binding]; other site 234621009781 Switch I region; other site 234621009782 Switch I region; other site 234621009783 G2 box; other site 234621009784 G2 box; other site 234621009785 Switch II region; other site 234621009786 G3 box; other site 234621009787 G4 box; other site 234621009788 G5 box; other site 234621009789 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 234621009790 G1 box; other site 234621009791 GTP/Mg2+ binding site [chemical binding]; other site 234621009792 Switch I region; other site 234621009793 G2 box; other site 234621009794 G3 box; other site 234621009795 Switch II region; other site 234621009796 G4 box; other site 234621009797 G5 box; other site 234621009798 cytidylate kinase; Provisional; Region: cmk; PRK00023 234621009799 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 234621009800 CMP-binding site; other site 234621009801 The sites determining sugar specificity; other site 234621009802 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 234621009803 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 234621009804 RNA binding surface [nucleotide binding]; other site 234621009805 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 234621009806 active site 234621009807 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 234621009808 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 234621009809 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 234621009810 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 234621009811 P-loop; other site 234621009812 Magnesium ion binding site [ion binding]; other site 234621009813 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 234621009814 Magnesium ion binding site [ion binding]; other site 234621009815 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 234621009816 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 234621009817 active site 234621009818 DNA binding site [nucleotide binding] 234621009819 Int/Topo IB signature motif; other site 234621009820 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 234621009821 dimer interface [polypeptide binding]; other site 234621009822 active site 234621009823 ADP-ribose binding site [chemical binding]; other site 234621009824 nudix motif; other site 234621009825 metal binding site [ion binding]; metal-binding site 234621009826 CTP synthetase; Validated; Region: pyrG; PRK05380 234621009827 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 234621009828 Catalytic site [active] 234621009829 active site 234621009830 UTP binding site [chemical binding]; other site 234621009831 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 234621009832 active site 234621009833 putative oxyanion hole; other site 234621009834 catalytic triad [active] 234621009835 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 234621009836 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 234621009837 Thiamine pyrophosphokinase; Region: TPK; cl08415 234621009838 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 234621009839 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 234621009840 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 234621009841 Walker A/P-loop; other site 234621009842 ATP binding site [chemical binding]; other site 234621009843 Q-loop/lid; other site 234621009844 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 234621009845 ABC transporter signature motif; other site 234621009846 Walker B; other site 234621009847 D-loop; other site 234621009848 H-loop/switch region; other site 234621009849 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 234621009850 ATP-NAD kinase; Region: NAD_kinase; pfam01513 234621009851 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 234621009852 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 234621009853 RNA binding surface [nucleotide binding]; other site 234621009854 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234621009855 S-adenosylmethionine binding site [chemical binding]; other site 234621009856 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 234621009857 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 234621009858 active site 234621009859 motif I; other site 234621009860 motif II; other site 234621009861 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 234621009862 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 234621009863 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 234621009864 active site 234621009865 HIGH motif; other site 234621009866 dimer interface [polypeptide binding]; other site 234621009867 KMSKS motif; other site 234621009868 S4 RNA-binding domain; Region: S4; smart00363 234621009869 RNA binding surface [nucleotide binding]; other site 234621009870 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 234621009871 active site 234621009872 DNA binding site [nucleotide binding] 234621009873 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 234621009874 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 234621009875 Walker A/P-loop; other site 234621009876 ATP binding site [chemical binding]; other site 234621009877 Q-loop/lid; other site 234621009878 ABC transporter signature motif; other site 234621009879 Walker B; other site 234621009880 D-loop; other site 234621009881 H-loop/switch region; other site 234621009882 ABC-2 type transporter; Region: ABC2_membrane; cl17235 234621009883 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 234621009884 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621009885 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621009886 Uncharacterized conserved protein [Function unknown]; Region: COG2835 234621009887 acyl-CoA synthetase; Validated; Region: PRK07868 234621009888 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621009889 acyl-activating enzyme (AAE) consensus motif; other site 234621009890 AMP binding site [chemical binding]; other site 234621009891 active site 234621009892 CoA binding site [chemical binding]; other site 234621009893 argininosuccinate lyase; Provisional; Region: PRK00855 234621009894 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 234621009895 active sites [active] 234621009896 tetramer interface [polypeptide binding]; other site 234621009897 argininosuccinate synthase; Provisional; Region: PRK13820 234621009898 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 234621009899 ANP binding site [chemical binding]; other site 234621009900 Substrate Binding Site II [chemical binding]; other site 234621009901 Substrate Binding Site I [chemical binding]; other site 234621009902 arginine repressor; Provisional; Region: PRK03341 234621009903 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 234621009904 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 234621009905 ornithine carbamoyltransferase; Provisional; Region: PRK00779 234621009906 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 234621009907 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 234621009908 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 234621009909 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 234621009910 inhibitor-cofactor binding pocket; inhibition site 234621009911 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234621009912 catalytic residue [active] 234621009913 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 234621009914 feedback inhibition sensing region; other site 234621009915 homohexameric interface [polypeptide binding]; other site 234621009916 nucleotide binding site [chemical binding]; other site 234621009917 N-acetyl-L-glutamate binding site [chemical binding]; other site 234621009918 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 234621009919 heterotetramer interface [polypeptide binding]; other site 234621009920 active site pocket [active] 234621009921 cleavage site 234621009922 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 234621009923 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 234621009924 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 234621009925 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 234621009926 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 234621009927 putative NAD(P) binding site [chemical binding]; other site 234621009928 active site 234621009929 putative substrate binding site [chemical binding]; other site 234621009930 bile acid transporter; Region: bass; TIGR00841 234621009931 Sodium Bile acid symporter family; Region: SBF; cl17470 234621009932 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 234621009933 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 234621009934 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 234621009935 AsnC family; Region: AsnC_trans_reg; pfam01037 234621009936 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 234621009937 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 234621009938 putative DNA binding site [nucleotide binding]; other site 234621009939 putative Zn2+ binding site [ion binding]; other site 234621009940 AsnC family; Region: AsnC_trans_reg; pfam01037 234621009941 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 234621009942 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 234621009943 putative tRNA-binding site [nucleotide binding]; other site 234621009944 B3/4 domain; Region: B3_4; pfam03483 234621009945 tRNA synthetase B5 domain; Region: B5; smart00874 234621009946 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 234621009947 dimer interface [polypeptide binding]; other site 234621009948 motif 1; other site 234621009949 motif 3; other site 234621009950 motif 2; other site 234621009951 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 234621009952 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 234621009953 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 234621009954 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 234621009955 dimer interface [polypeptide binding]; other site 234621009956 motif 1; other site 234621009957 active site 234621009958 motif 2; other site 234621009959 motif 3; other site 234621009960 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 234621009961 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 234621009962 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 234621009963 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 234621009964 23S rRNA binding site [nucleotide binding]; other site 234621009965 L21 binding site [polypeptide binding]; other site 234621009966 L13 binding site [polypeptide binding]; other site 234621009967 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 234621009968 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 234621009969 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 234621009970 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 234621009971 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 234621009972 HTH domain; Region: HTH_11; pfam08279 234621009973 WYL domain; Region: WYL; pfam13280 234621009974 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 234621009975 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 234621009976 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 234621009977 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 234621009978 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 234621009979 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 234621009980 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 234621009981 Protein of unknown function (DUF2716); Region: DUF2716; pfam10898 234621009982 Predicted membrane protein [Function unknown]; Region: COG2259 234621009983 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 234621009984 Part of AAA domain; Region: AAA_19; pfam13245 234621009985 Family description; Region: UvrD_C_2; pfam13538 234621009986 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 234621009987 Ligand Binding Site [chemical binding]; other site 234621009988 excinuclease ABC subunit B; Provisional; Region: PRK05298 234621009989 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 234621009990 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 234621009991 nucleotide binding region [chemical binding]; other site 234621009992 ATP-binding site [chemical binding]; other site 234621009993 Ultra-violet resistance protein B; Region: UvrB; pfam12344 234621009994 UvrB/uvrC motif; Region: UVR; pfam02151 234621009995 Protein of unknown function (DUF402); Region: DUF402; cl00979 234621009996 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 234621009997 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 234621009998 CoA-binding site [chemical binding]; other site 234621009999 ATP-binding [chemical binding]; other site 234621010000 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 234621010001 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 234621010002 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 234621010003 RNA binding site [nucleotide binding]; other site 234621010004 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 234621010005 RNA binding site [nucleotide binding]; other site 234621010006 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 234621010007 RNA binding site [nucleotide binding]; other site 234621010008 S1 RNA binding domain; Region: S1; pfam00575 234621010009 RNA binding site [nucleotide binding]; other site 234621010010 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234621010011 S-adenosylmethionine binding site [chemical binding]; other site 234621010012 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 234621010013 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 234621010014 Walker A/P-loop; other site 234621010015 ATP binding site [chemical binding]; other site 234621010016 Q-loop/lid; other site 234621010017 ABC transporter signature motif; other site 234621010018 Walker B; other site 234621010019 D-loop; other site 234621010020 H-loop/switch region; other site 234621010021 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 234621010022 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234621010023 dimer interface [polypeptide binding]; other site 234621010024 conserved gate region; other site 234621010025 putative PBP binding loops; other site 234621010026 ABC-ATPase subunit interface; other site 234621010027 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 234621010028 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 234621010029 substrate binding pocket [chemical binding]; other site 234621010030 membrane-bound complex binding site; other site 234621010031 hinge residues; other site 234621010032 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 234621010033 tartrate dehydrogenase; Region: TTC; TIGR02089 234621010034 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 234621010035 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 234621010036 EamA-like transporter family; Region: EamA; pfam00892 234621010037 EamA-like transporter family; Region: EamA; pfam00892 234621010038 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 234621010039 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 234621010040 conserved cys residue [active] 234621010041 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 234621010042 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 234621010043 catalytic residues [active] 234621010044 DNA polymerase I; Provisional; Region: PRK05755 234621010045 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 234621010046 active site 234621010047 metal binding site 1 [ion binding]; metal-binding site 234621010048 putative 5' ssDNA interaction site; other site 234621010049 metal binding site 3; metal-binding site 234621010050 metal binding site 2 [ion binding]; metal-binding site 234621010051 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 234621010052 putative DNA binding site [nucleotide binding]; other site 234621010053 putative metal binding site [ion binding]; other site 234621010054 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 234621010055 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 234621010056 active site 234621010057 DNA binding site [nucleotide binding] 234621010058 catalytic site [active] 234621010059 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 234621010060 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 234621010061 TM-ABC transporter signature motif; other site 234621010062 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 234621010063 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 234621010064 TM-ABC transporter signature motif; other site 234621010065 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 234621010066 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 234621010067 Walker A/P-loop; other site 234621010068 ATP binding site [chemical binding]; other site 234621010069 Q-loop/lid; other site 234621010070 ABC transporter signature motif; other site 234621010071 Walker B; other site 234621010072 D-loop; other site 234621010073 H-loop/switch region; other site 234621010074 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 234621010075 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 234621010076 Walker A/P-loop; other site 234621010077 ATP binding site [chemical binding]; other site 234621010078 Q-loop/lid; other site 234621010079 ABC transporter signature motif; other site 234621010080 Walker B; other site 234621010081 D-loop; other site 234621010082 H-loop/switch region; other site 234621010083 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 234621010084 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 234621010085 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 234621010086 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234621010087 active site 234621010088 phosphorylation site [posttranslational modification] 234621010089 intermolecular recognition site; other site 234621010090 dimerization interface [polypeptide binding]; other site 234621010091 ANTAR domain; Region: ANTAR; pfam03861 234621010092 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 234621010093 DNA binding site [nucleotide binding] 234621010094 Int/Topo IB signature motif; other site 234621010095 active site 234621010096 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234621010097 non-specific DNA binding site [nucleotide binding]; other site 234621010098 salt bridge; other site 234621010099 sequence-specific DNA binding site [nucleotide binding]; other site 234621010100 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 234621010101 polymerase nucleotide-binding site; other site 234621010102 DNA-binding residues [nucleotide binding]; DNA binding site 234621010103 nucleotide binding site [chemical binding]; other site 234621010104 primase nucleotide-binding site [nucleotide binding]; other site 234621010105 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 234621010106 Helix-turn-helix domain; Region: HTH_17; pfam12728 234621010107 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14192 234621010108 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 234621010109 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 234621010110 homodimer interface [polypeptide binding]; other site 234621010111 NADP binding site [chemical binding]; other site 234621010112 substrate binding site [chemical binding]; other site 234621010113 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 234621010114 putative hydrophobic ligand binding site [chemical binding]; other site 234621010115 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 234621010116 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 234621010117 active site 234621010118 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 234621010119 catalytic triad [active] 234621010120 dimer interface [polypeptide binding]; other site 234621010121 pyruvate kinase; Provisional; Region: PRK06247 234621010122 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 234621010123 domain interfaces; other site 234621010124 active site 234621010125 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 234621010126 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 234621010127 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 234621010128 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 234621010129 active site 234621010130 dimer interface [polypeptide binding]; other site 234621010131 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 234621010132 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 234621010133 active site 234621010134 FMN binding site [chemical binding]; other site 234621010135 substrate binding site [chemical binding]; other site 234621010136 3Fe-4S cluster binding site [ion binding]; other site 234621010137 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 234621010138 domain interface; other site 234621010139 TM2 domain; Region: TM2; pfam05154 234621010140 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 234621010141 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 234621010142 substrate binding site [chemical binding]; other site 234621010143 active site 234621010144 catalytic residues [active] 234621010145 heterodimer interface [polypeptide binding]; other site 234621010146 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 234621010147 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 234621010148 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234621010149 catalytic residue [active] 234621010150 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 234621010151 active site 234621010152 ribulose/triose binding site [chemical binding]; other site 234621010153 phosphate binding site [ion binding]; other site 234621010154 substrate (anthranilate) binding pocket [chemical binding]; other site 234621010155 product (indole) binding pocket [chemical binding]; other site 234621010156 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 234621010157 anthranilate synthase component I; Provisional; Region: PRK13571 234621010158 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 234621010159 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 234621010160 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 234621010161 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 234621010162 catalytic triad [active] 234621010163 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 234621010164 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 234621010165 putative active site [active] 234621010166 metal binding site [ion binding]; metal-binding site 234621010167 MarR family; Region: MarR_2; cl17246 234621010168 3-ketosteroid-delta-1-dehydrogenase; Provisional; Region: PRK12837 234621010169 Predicted oxidoreductase [General function prediction only]; Region: COG3573 234621010170 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 234621010171 mce related protein; Region: MCE; pfam02470 234621010172 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 234621010173 mce related protein; Region: MCE; pfam02470 234621010174 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 234621010175 mce related protein; Region: MCE; pfam02470 234621010176 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 234621010177 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 234621010178 mce related protein; Region: MCE; pfam02470 234621010179 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 234621010180 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 234621010181 mce related protein; Region: MCE; pfam02470 234621010182 mce related protein; Region: MCE; pfam02470 234621010183 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 234621010184 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 234621010185 Permease; Region: Permease; pfam02405 234621010186 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 234621010187 Permease; Region: Permease; pfam02405 234621010188 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 234621010189 Cytochrome P450; Region: p450; cl12078 234621010190 acyl-CoA synthetase; Validated; Region: PRK07798 234621010191 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621010192 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 234621010193 acyl-activating enzyme (AAE) consensus motif; other site 234621010194 acyl-activating enzyme (AAE) consensus motif; other site 234621010195 putative AMP binding site [chemical binding]; other site 234621010196 putative active site [active] 234621010197 putative CoA binding site [chemical binding]; other site 234621010198 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 234621010199 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 234621010200 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 234621010201 Cytochrome P450; Region: p450; cl12078 234621010202 short chain dehydrogenase; Provisional; Region: PRK07775 234621010203 classical (c) SDRs; Region: SDR_c; cd05233 234621010204 NAD(P) binding site [chemical binding]; other site 234621010205 active site 234621010206 Cytochrome P450; Region: p450; cl12078 234621010207 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 234621010208 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 234621010209 classical (c) SDRs; Region: SDR_c; cd05233 234621010210 NAD(P) binding site [chemical binding]; other site 234621010211 active site 234621010212 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 234621010213 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 234621010214 NAD binding site [chemical binding]; other site 234621010215 catalytic residues [active] 234621010216 short chain dehydrogenase; Provisional; Region: PRK07774 234621010217 classical (c) SDRs; Region: SDR_c; cd05233 234621010218 NAD(P) binding site [chemical binding]; other site 234621010219 active site 234621010220 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 234621010221 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 234621010222 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 234621010223 hypothetical protein; Validated; Region: PRK07121 234621010224 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 234621010225 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 234621010226 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 234621010227 dimerization interface [polypeptide binding]; other site 234621010228 putative DNA binding site [nucleotide binding]; other site 234621010229 putative Zn2+ binding site [ion binding]; other site 234621010230 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 234621010231 Putative esterase; Region: Esterase; pfam00756 234621010232 Condensation domain; Region: Condensation; pfam00668 234621010233 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 234621010234 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 234621010235 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 234621010236 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 234621010237 acyl-activating enzyme (AAE) consensus motif; other site 234621010238 AMP binding site [chemical binding]; other site 234621010239 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 234621010240 Condensation domain; Region: Condensation; pfam00668 234621010241 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 234621010242 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 234621010243 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621010244 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 234621010245 acyl-activating enzyme (AAE) consensus motif; other site 234621010246 AMP binding site [chemical binding]; other site 234621010247 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621010248 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 234621010249 Condensation domain; Region: Condensation; pfam00668 234621010250 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 234621010251 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 234621010252 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 234621010253 acyl-activating enzyme (AAE) consensus motif; other site 234621010254 AMP binding site [chemical binding]; other site 234621010255 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 234621010256 Condensation domain; Region: Condensation; pfam00668 234621010257 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 234621010258 Condensation domain; Region: Condensation; pfam00668 234621010259 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 234621010260 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621010261 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 234621010262 acyl-activating enzyme (AAE) consensus motif; other site 234621010263 AMP binding site [chemical binding]; other site 234621010264 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621010265 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 234621010266 Condensation domain; Region: Condensation; pfam00668 234621010267 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 234621010268 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 234621010269 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 234621010270 acyl-activating enzyme (AAE) consensus motif; other site 234621010271 AMP binding site [chemical binding]; other site 234621010272 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 234621010273 Condensation domain; Region: Condensation; pfam00668 234621010274 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 234621010275 Condensation domain; Region: Condensation; pfam00668 234621010276 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 234621010277 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 234621010278 acyl-activating enzyme (AAE) consensus motif; other site 234621010279 AMP binding site [chemical binding]; other site 234621010280 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 234621010281 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 234621010282 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 234621010283 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 234621010284 acyl-activating enzyme (AAE) consensus motif; other site 234621010285 AMP binding site [chemical binding]; other site 234621010286 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 234621010287 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 234621010288 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 234621010289 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 234621010290 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 234621010291 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 234621010292 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 234621010293 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 234621010294 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 234621010295 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621010296 putative substrate translocation pore; other site 234621010297 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621010298 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 234621010299 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 234621010300 FOG: CBS domain [General function prediction only]; Region: COG0517 234621010301 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 234621010302 phosphoenolpyruvate synthase; Validated; Region: PRK06464 234621010303 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 234621010304 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 234621010305 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 234621010306 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 234621010307 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 234621010308 putative substrate binding site [chemical binding]; other site 234621010309 putative ATP binding site [chemical binding]; other site 234621010310 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 234621010311 Coenzyme A binding pocket [chemical binding]; other site 234621010312 4Fe-4S dicluster domain; Region: Fer4_18; pfam13746 234621010313 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 234621010314 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 234621010315 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 234621010316 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 234621010317 FAD binding pocket [chemical binding]; other site 234621010318 FAD binding motif [chemical binding]; other site 234621010319 phosphate binding motif [ion binding]; other site 234621010320 beta-alpha-beta structure motif; other site 234621010321 NAD binding pocket [chemical binding]; other site 234621010322 Iron coordination center [ion binding]; other site 234621010323 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 234621010324 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 234621010325 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 234621010326 nickel binding site [ion binding]; other site 234621010327 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 234621010328 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 234621010329 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 234621010330 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 234621010331 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 234621010332 active site 234621010333 motif I; other site 234621010334 motif II; other site 234621010335 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 234621010336 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 234621010337 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 234621010338 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 234621010339 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 234621010340 Ligand Binding Site [chemical binding]; other site 234621010341 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 234621010342 Ligand Binding Site [chemical binding]; other site 234621010343 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 234621010344 active site 234621010345 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 234621010346 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 234621010347 active site 234621010348 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 234621010349 Beta-lactamase; Region: Beta-lactamase; pfam00144 234621010350 golgi membrane calcium-translocating P-type ATPase; Region: ATPase-IIA2_Ca; TIGR01522 234621010351 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 234621010352 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 234621010353 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 234621010354 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 234621010355 active site 234621010356 motif I; other site 234621010357 motif II; other site 234621010358 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 234621010359 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 234621010360 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 234621010361 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 234621010362 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 234621010363 Soluble P-type ATPase [General function prediction only]; Region: COG4087 234621010364 Hemerythrin-like domain; Region: Hr-like; cd12108 234621010365 Fe binding site [ion binding]; other site 234621010366 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 234621010367 Predicted kinase [General function prediction only]; Region: COG0645 234621010368 AAA domain; Region: AAA_17; pfam13207 234621010369 hypothetical protein; Provisional; Region: PRK07877 234621010370 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 234621010371 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 234621010372 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 234621010373 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 234621010374 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 234621010375 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234621010376 ATP binding site [chemical binding]; other site 234621010377 Mg2+ binding site [ion binding]; other site 234621010378 G-X-G motif; other site 234621010379 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 234621010380 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234621010381 active site 234621010382 phosphorylation site [posttranslational modification] 234621010383 intermolecular recognition site; other site 234621010384 dimerization interface [polypeptide binding]; other site 234621010385 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 234621010386 DNA binding residues [nucleotide binding] 234621010387 dimerization interface [polypeptide binding]; other site 234621010388 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 234621010389 dimer interface [polypeptide binding]; other site 234621010390 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 234621010391 Ligand Binding Site [chemical binding]; other site 234621010392 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 234621010393 Ligand Binding Site [chemical binding]; other site 234621010394 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 234621010395 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 234621010396 putative NAD(P) binding site [chemical binding]; other site 234621010397 putative substrate binding site [chemical binding]; other site 234621010398 catalytic Zn binding site [ion binding]; other site 234621010399 structural Zn binding site [ion binding]; other site 234621010400 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 234621010401 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 234621010402 motif II; other site 234621010403 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 234621010404 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 234621010405 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 234621010406 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 234621010407 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 234621010408 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 234621010409 Ligand Binding Site [chemical binding]; other site 234621010410 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 234621010411 Ligand Binding Site [chemical binding]; other site 234621010412 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621010413 NAD(P) binding site [chemical binding]; other site 234621010414 active site 234621010415 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 234621010416 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 234621010417 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 234621010418 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 234621010419 active site 234621010420 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 234621010421 active site 234621010422 metal binding site [ion binding]; metal-binding site 234621010423 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 234621010424 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 234621010425 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 234621010426 dimerization interface [polypeptide binding]; other site 234621010427 putative DNA binding site [nucleotide binding]; other site 234621010428 putative Zn2+ binding site [ion binding]; other site 234621010429 Domain of unknown function (DUF385); Region: DUF385; pfam04075 234621010430 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 234621010431 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 234621010432 putative hydrophobic ligand binding site [chemical binding]; other site 234621010433 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 234621010434 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 234621010435 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 234621010436 Ligand Binding Site [chemical binding]; other site 234621010437 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 234621010438 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 234621010439 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621010440 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621010441 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 234621010442 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 234621010443 substrate binding site [chemical binding]; other site 234621010444 glutamase interaction surface [polypeptide binding]; other site 234621010445 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 234621010446 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 234621010447 active site 234621010448 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 234621010449 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 234621010450 catalytic residues [active] 234621010451 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 234621010452 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 234621010453 putative active site [active] 234621010454 oxyanion strand; other site 234621010455 catalytic triad [active] 234621010456 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621010457 Major Facilitator Superfamily; Region: MFS_1; pfam07690 234621010458 putative substrate translocation pore; other site 234621010459 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 234621010460 putative active site pocket [active] 234621010461 4-fold oligomerization interface [polypeptide binding]; other site 234621010462 metal binding residues [ion binding]; metal-binding site 234621010463 3-fold/trimer interface [polypeptide binding]; other site 234621010464 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 234621010465 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 234621010466 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234621010467 homodimer interface [polypeptide binding]; other site 234621010468 catalytic residue [active] 234621010469 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 234621010470 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 234621010471 NAD binding site [chemical binding]; other site 234621010472 dimerization interface [polypeptide binding]; other site 234621010473 product binding site; other site 234621010474 substrate binding site [chemical binding]; other site 234621010475 zinc binding site [ion binding]; other site 234621010476 catalytic residues [active] 234621010477 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 234621010478 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 234621010479 beta-galactosidase; Region: BGL; TIGR03356 234621010480 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 234621010481 Cupin domain; Region: Cupin_2; pfam07883 234621010482 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 234621010483 RibD C-terminal domain; Region: RibD_C; cl17279 234621010484 Nitroreductase family; Region: Nitroreductase; pfam00881 234621010485 dimer interface [polypeptide binding]; other site 234621010486 LysE type translocator; Region: LysE; cl00565 234621010487 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 234621010488 Secretory lipase; Region: LIP; pfam03583 234621010489 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 234621010490 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234621010491 S-adenosylmethionine binding site [chemical binding]; other site 234621010492 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 234621010493 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 234621010494 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 234621010495 catalytic residue [active] 234621010496 MFS/sugar transport protein; Region: MFS_2; pfam13347 234621010497 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 234621010498 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 234621010499 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 234621010500 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 234621010501 Condensation domain; Region: Condensation; pfam00668 234621010502 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 234621010503 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 234621010504 acyl-activating enzyme (AAE) consensus motif; other site 234621010505 AMP binding site [chemical binding]; other site 234621010506 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 234621010507 Condensation domain; Region: Condensation; pfam00668 234621010508 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 234621010509 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 234621010510 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 234621010511 acyl-activating enzyme (AAE) consensus motif; other site 234621010512 AMP binding site [chemical binding]; other site 234621010513 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 234621010514 Condensation domain; Region: Condensation; pfam00668 234621010515 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 234621010516 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 234621010517 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 234621010518 acyl-activating enzyme (AAE) consensus motif; other site 234621010519 AMP binding site [chemical binding]; other site 234621010520 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 234621010521 Condensation domain; Region: Condensation; pfam00668 234621010522 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 234621010523 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 234621010524 acyl-activating enzyme (AAE) consensus motif; other site 234621010525 AMP binding site [chemical binding]; other site 234621010526 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 234621010527 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 234621010528 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 234621010529 acyl-activating enzyme (AAE) consensus motif; other site 234621010530 AMP binding site [chemical binding]; other site 234621010531 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 234621010532 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 234621010533 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 234621010534 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 234621010535 siderophore binding site; other site 234621010536 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 234621010537 non-specific DNA interactions [nucleotide binding]; other site 234621010538 DNA binding site [nucleotide binding] 234621010539 sequence specific DNA binding site [nucleotide binding]; other site 234621010540 putative cAMP binding site [chemical binding]; other site 234621010541 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 234621010542 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 234621010543 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 234621010544 Coenzyme A binding pocket [chemical binding]; other site 234621010545 Domain of unknown function (DUF222); Region: DUF222; pfam02720 234621010546 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 234621010547 active site 234621010548 Class I aldolases; Region: Aldolase_Class_I; cl17187 234621010549 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 234621010550 catalytic residue [active] 234621010551 Transcriptional regulator [Transcription]; Region: LysR; COG0583 234621010552 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 234621010553 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 234621010554 putative dimerization interface [polypeptide binding]; other site 234621010555 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 234621010556 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 234621010557 dimerization interface [polypeptide binding]; other site 234621010558 active site 234621010559 L-aspartate oxidase; Provisional; Region: PRK07804 234621010560 L-aspartate oxidase; Provisional; Region: PRK06175 234621010561 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 234621010562 quinolinate synthetase; Provisional; Region: PRK09375 234621010563 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 234621010564 nudix motif; other site 234621010565 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 234621010566 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621010567 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621010568 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621010569 WHG domain; Region: WHG; pfam13305 234621010570 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 234621010571 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621010572 NAD(P) binding site [chemical binding]; other site 234621010573 active site 234621010574 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 234621010575 biotin synthase; Validated; Region: PRK06256 234621010576 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 234621010577 FeS/SAM binding site; other site 234621010578 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 234621010579 tetracycline repressor protein TetR; Provisional; Region: PRK13756 234621010580 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621010581 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 234621010582 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 234621010583 AzlC protein; Region: AzlC; pfam03591 234621010584 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234621010585 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 234621010586 non-specific DNA binding site [nucleotide binding]; other site 234621010587 salt bridge; other site 234621010588 sequence-specific DNA binding site [nucleotide binding]; other site 234621010589 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 234621010590 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234621010591 active site 234621010592 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 234621010593 active site 234621010594 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234621010595 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 234621010596 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 234621010597 GAF domain; Region: GAF; pfam01590 234621010598 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 234621010599 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 234621010600 homodimer interface [polypeptide binding]; other site 234621010601 catalytic residues [active] 234621010602 NAD binding site [chemical binding]; other site 234621010603 substrate binding pocket [chemical binding]; other site 234621010604 flexible flap; other site 234621010605 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 234621010606 active site 234621010607 catalytic residues [active] 234621010608 metal binding site [ion binding]; metal-binding site 234621010609 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 234621010610 MASE1; Region: MASE1; cl17823 234621010611 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 234621010612 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 234621010613 metal binding site [ion binding]; metal-binding site 234621010614 active site 234621010615 I-site; other site 234621010616 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 234621010617 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 234621010618 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 234621010619 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 234621010620 catalytic residue [active] 234621010621 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 234621010622 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 234621010623 inhibitor-cofactor binding pocket; inhibition site 234621010624 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234621010625 catalytic residue [active] 234621010626 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 234621010627 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 234621010628 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 234621010629 active site 234621010630 catalytic site [active] 234621010631 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 234621010632 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 234621010633 active site 234621010634 catalytic site [active] 234621010635 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 234621010636 classical (c) SDRs; Region: SDR_c; cd05233 234621010637 NAD(P) binding site [chemical binding]; other site 234621010638 active site 234621010639 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 234621010640 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 234621010641 putative NAD(P) binding site [chemical binding]; other site 234621010642 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 234621010643 CoenzymeA binding site [chemical binding]; other site 234621010644 subunit interaction site [polypeptide binding]; other site 234621010645 PHB binding site; other site 234621010646 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621010647 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621010648 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 234621010649 Transcriptional regulator [Transcription]; Region: LysR; COG0583 234621010650 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 234621010651 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 234621010652 dimerization interface [polypeptide binding]; other site 234621010653 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 234621010654 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621010655 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621010656 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 234621010657 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 234621010658 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621010659 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234621010660 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 234621010661 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621010662 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621010663 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 234621010664 Low molecular weight phosphatase family; Region: LMWPc; cd00115 234621010665 active site 234621010666 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 234621010667 arsenical-resistance protein; Region: acr3; TIGR00832 234621010668 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 234621010669 dimerization interface [polypeptide binding]; other site 234621010670 putative DNA binding site [nucleotide binding]; other site 234621010671 putative Zn2+ binding site [ion binding]; other site 234621010672 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 234621010673 dimerization interface [polypeptide binding]; other site 234621010674 putative DNA binding site [nucleotide binding]; other site 234621010675 putative Zn2+ binding site [ion binding]; other site 234621010676 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 234621010677 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 234621010678 Coenzyme A binding pocket [chemical binding]; other site 234621010679 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 234621010680 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 234621010681 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 234621010682 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 234621010683 catalytic site [active] 234621010684 active site 234621010685 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 234621010686 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 234621010687 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621010688 putative substrate translocation pore; other site 234621010689 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 234621010690 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621010691 threonine dehydratase; Validated; Region: PRK08639 234621010692 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 234621010693 tetramer interface [polypeptide binding]; other site 234621010694 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234621010695 catalytic residue [active] 234621010696 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 234621010697 pyruvate dehydrogenase; Provisional; Region: PRK06546 234621010698 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 234621010699 PYR/PP interface [polypeptide binding]; other site 234621010700 dimer interface [polypeptide binding]; other site 234621010701 tetramer interface [polypeptide binding]; other site 234621010702 TPP binding site [chemical binding]; other site 234621010703 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 234621010704 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 234621010705 TPP-binding site [chemical binding]; other site 234621010706 Domain of unknown function (DUF385); Region: DUF385; pfam04075 234621010707 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 234621010708 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 234621010709 active site 234621010710 PHP Thumb interface [polypeptide binding]; other site 234621010711 metal binding site [ion binding]; metal-binding site 234621010712 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 234621010713 generic binding surface II; other site 234621010714 generic binding surface I; other site 234621010715 Predicted permeases [General function prediction only]; Region: RarD; COG2962 234621010716 EamA-like transporter family; Region: EamA; cl17759 234621010717 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 234621010718 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 234621010719 active site 234621010720 lipoprotein signal peptidase; Provisional; Region: PRK14764 234621010721 lipoprotein signal peptidase; Provisional; Region: PRK14787 234621010722 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 234621010723 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 234621010724 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234621010725 catalytic residue [active] 234621010726 DNA polymerase IV; Provisional; Region: PRK03348 234621010727 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 234621010728 active site 234621010729 DNA binding site [nucleotide binding] 234621010730 TfoX N-terminal domain; Region: TfoX_N; pfam04993 234621010731 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 234621010732 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 234621010733 HIGH motif; other site 234621010734 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 234621010735 active site 234621010736 KMSKS motif; other site 234621010737 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 234621010738 tRNA binding surface [nucleotide binding]; other site 234621010739 anticodon binding site; other site 234621010740 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 234621010741 DivIVA domain; Region: DivI1A_domain; TIGR03544 234621010742 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 234621010743 YGGT family; Region: YGGT; cl00508 234621010744 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 234621010745 Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325 234621010746 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 234621010747 catalytic residue [active] 234621010748 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 234621010749 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 234621010750 cell division protein FtsZ; Validated; Region: PRK09330 234621010751 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 234621010752 nucleotide binding site [chemical binding]; other site 234621010753 SulA interaction site; other site 234621010754 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 234621010755 Cell division protein FtsQ; Region: FtsQ; pfam03799 234621010756 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 234621010757 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 234621010758 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 234621010759 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 234621010760 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 234621010761 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 234621010762 active site 234621010763 homodimer interface [polypeptide binding]; other site 234621010764 cell division protein FtsW; Region: ftsW; TIGR02614 234621010765 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 234621010766 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; pfam01488 234621010767 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 234621010768 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 234621010769 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 234621010770 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 234621010771 Mg++ binding site [ion binding]; other site 234621010772 putative catalytic motif [active] 234621010773 putative substrate binding site [chemical binding]; other site 234621010774 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 234621010775 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 234621010776 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 234621010777 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 234621010778 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 234621010779 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 234621010780 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 234621010781 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 234621010782 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 234621010783 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 234621010784 MraW methylase family; Region: Methyltransf_5; cl17771 234621010785 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 234621010786 cell division protein MraZ; Reviewed; Region: PRK00326 234621010787 MraZ protein; Region: MraZ; pfam02381 234621010788 MraZ protein; Region: MraZ; pfam02381 234621010789 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 234621010790 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 234621010791 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 234621010792 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 234621010793 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 234621010794 FAD binding site [chemical binding]; other site 234621010795 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 234621010796 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 234621010797 substrate binding pocket [chemical binding]; other site 234621010798 chain length determination region; other site 234621010799 substrate-Mg2+ binding site; other site 234621010800 catalytic residues [active] 234621010801 aspartate-rich region 1; other site 234621010802 active site lid residues [active] 234621010803 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 234621010804 aspartate-rich region 2; other site 234621010805 phytoene desaturase; Region: crtI_fam; TIGR02734 234621010806 hydroxyglutarate oxidase; Provisional; Region: PRK11728 234621010807 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 234621010808 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 234621010809 active site lid residues [active] 234621010810 substrate binding pocket [chemical binding]; other site 234621010811 catalytic residues [active] 234621010812 substrate-Mg2+ binding site; other site 234621010813 aspartate-rich region 1; other site 234621010814 aspartate-rich region 2; other site 234621010815 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234621010816 Catalytic domain of Protein Kinases; Region: PKc; cd00180 234621010817 active site 234621010818 ATP binding site [chemical binding]; other site 234621010819 substrate binding site [chemical binding]; other site 234621010820 activation loop (A-loop); other site 234621010821 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 234621010822 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 234621010823 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 234621010824 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 234621010825 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 234621010826 active site 234621010827 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 234621010828 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 234621010829 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 234621010830 putative acyl-acceptor binding pocket; other site 234621010831 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 234621010832 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 234621010833 nucleotide binding site [chemical binding]; other site 234621010834 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 234621010835 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 234621010836 P loop; other site 234621010837 Nucleotide binding site [chemical binding]; other site 234621010838 DTAP/Switch II; other site 234621010839 Switch I; other site 234621010840 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 234621010841 putative hydrophobic ligand binding site [chemical binding]; other site 234621010842 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 234621010843 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 234621010844 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 234621010845 acyl-activating enzyme (AAE) consensus motif; other site 234621010846 putative AMP binding site [chemical binding]; other site 234621010847 putative active site [active] 234621010848 putative CoA binding site [chemical binding]; other site 234621010849 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 234621010850 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 234621010851 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 234621010852 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 234621010853 NlpC/P60 family; Region: NLPC_P60; pfam00877 234621010854 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 234621010855 NlpC/P60 family; Region: NLPC_P60; pfam00877 234621010856 hypothetical protein; Validated; Region: PRK07883 234621010857 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 234621010858 active site 234621010859 catalytic site [active] 234621010860 substrate binding site [chemical binding]; other site 234621010861 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 234621010862 GIY-YIG motif/motif A; other site 234621010863 active site 234621010864 catalytic site [active] 234621010865 putative DNA binding site [nucleotide binding]; other site 234621010866 metal binding site [ion binding]; metal-binding site 234621010867 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 234621010868 AsnC family; Region: AsnC_trans_reg; pfam01037 234621010869 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 234621010870 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 234621010871 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 234621010872 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 234621010873 Subunit I/III interface [polypeptide binding]; other site 234621010874 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 234621010875 Cytochrome c; Region: Cytochrom_C; cl11414 234621010876 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 234621010877 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 234621010878 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 234621010879 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 234621010880 iron-sulfur cluster [ion binding]; other site 234621010881 [2Fe-2S] cluster binding site [ion binding]; other site 234621010882 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 234621010883 heme bH binding site [chemical binding]; other site 234621010884 intrachain domain interface; other site 234621010885 heme bL binding site [chemical binding]; other site 234621010886 interchain domain interface [polypeptide binding]; other site 234621010887 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 234621010888 Qo binding site; other site 234621010889 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 234621010890 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 234621010891 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 234621010892 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 234621010893 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 234621010894 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 234621010895 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 234621010896 dimer interface [polypeptide binding]; other site 234621010897 active site 234621010898 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 234621010899 Ligand Binding Site [chemical binding]; other site 234621010900 Molecular Tunnel; other site 234621010901 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 234621010902 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 234621010903 substrate binding site [chemical binding]; other site 234621010904 ATP binding site [chemical binding]; other site 234621010905 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 234621010906 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 234621010907 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 234621010908 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 234621010909 homotrimer interface [polypeptide binding]; other site 234621010910 Walker A motif; other site 234621010911 GTP binding site [chemical binding]; other site 234621010912 Walker B motif; other site 234621010913 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 234621010914 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 234621010915 putative dimer interface [polypeptide binding]; other site 234621010916 active site pocket [active] 234621010917 putative cataytic base [active] 234621010918 cobalamin synthase; Reviewed; Region: cobS; PRK00235 234621010919 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 234621010920 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 234621010921 conserved cys residue [active] 234621010922 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 234621010923 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 234621010924 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 234621010925 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 234621010926 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 234621010927 homodimer interface [polypeptide binding]; other site 234621010928 substrate-cofactor binding pocket; other site 234621010929 catalytic residue [active] 234621010930 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 234621010931 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 234621010932 multifunctional aminopeptidase A; Provisional; Region: PRK00913 234621010933 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 234621010934 interface (dimer of trimers) [polypeptide binding]; other site 234621010935 Substrate-binding/catalytic site; other site 234621010936 Zn-binding sites [ion binding]; other site 234621010937 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 234621010938 E3 interaction surface; other site 234621010939 lipoyl attachment site [posttranslational modification]; other site 234621010940 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 234621010941 E3 interaction surface; other site 234621010942 lipoyl attachment site [posttranslational modification]; other site 234621010943 e3 binding domain; Region: E3_binding; pfam02817 234621010944 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 234621010945 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 234621010946 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 234621010947 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 234621010948 putative NAD(P) binding site [chemical binding]; other site 234621010949 putative active site [active] 234621010950 lipoate-protein ligase B; Provisional; Region: PRK14345 234621010951 lipoyl synthase; Provisional; Region: PRK05481 234621010952 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 234621010953 FeS/SAM binding site; other site 234621010954 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 234621010955 RDD family; Region: RDD; pfam06271 234621010956 glutamine synthetase, type I; Region: GlnA; TIGR00653 234621010957 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 234621010958 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 234621010959 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 234621010960 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 234621010961 Predicted transcriptional regulator [Transcription]; Region: COG2378 234621010962 HTH domain; Region: HTH_11; pfam08279 234621010963 WYL domain; Region: WYL; pfam13280 234621010964 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 234621010965 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 234621010966 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 234621010967 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 234621010968 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 234621010969 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 234621010970 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 234621010971 Putative esterase; Region: Esterase; pfam00756 234621010972 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234621010973 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 234621010974 active site 234621010975 metal binding site [ion binding]; metal-binding site 234621010976 Helix-turn-helix domain; Region: HTH_18; pfam12833 234621010977 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 234621010978 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217 234621010979 Actin depolymerization factor/cofilin- and gelsolin-like domains; Region: ADF_gelsolin; cl15697 234621010980 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 234621010981 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 234621010982 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 234621010983 substrate binding site [chemical binding]; other site 234621010984 multimerization interface [polypeptide binding]; other site 234621010985 ATP binding site [chemical binding]; other site 234621010986 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 234621010987 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 234621010988 active site residue [active] 234621010989 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 234621010990 active site residue [active] 234621010991 Transcriptional regulators [Transcription]; Region: GntR; COG1802 234621010992 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 234621010993 DNA-binding site [nucleotide binding]; DNA binding site 234621010994 FCD domain; Region: FCD; pfam07729 234621010995 Cupin; Region: Cupin_1; smart00835 234621010996 Cupin; Region: Cupin_1; smart00835 234621010997 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 234621010998 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 234621010999 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234621011000 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 234621011001 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 234621011002 NAD binding site [chemical binding]; other site 234621011003 catalytic Zn binding site [ion binding]; other site 234621011004 substrate binding site [chemical binding]; other site 234621011005 structural Zn binding site [ion binding]; other site 234621011006 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 234621011007 S-adenosylmethionine binding site [chemical binding]; other site 234621011008 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 234621011009 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 234621011010 metal binding triad; other site 234621011011 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 234621011012 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 234621011013 metal binding triad; other site 234621011014 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 234621011015 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 234621011016 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 234621011017 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 234621011018 TAP-like protein; Region: Abhydrolase_4; pfam08386 234621011019 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 234621011020 oligomerization interface [polypeptide binding]; other site 234621011021 active site 234621011022 metal binding site [ion binding]; metal-binding site 234621011023 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 234621011024 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 234621011025 TAP-like protein; Region: Abhydrolase_4; pfam08386 234621011026 RNB domain; Region: RNB; pfam00773 234621011027 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 234621011028 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 234621011029 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 234621011030 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 234621011031 transmembrane helices; other site 234621011032 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 234621011033 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 234621011034 RNA/DNA hybrid binding site [nucleotide binding]; other site 234621011035 active site 234621011036 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 234621011037 catalytic core [active] 234621011038 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 234621011039 Putative zinc ribbon domain; Region: DUF164; pfam02591 234621011040 Uncharacterized conserved protein [Function unknown]; Region: COG0327 234621011041 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 234621011042 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 234621011043 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 234621011044 hypothetical protein; Provisional; Region: PRK07908 234621011045 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 234621011046 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234621011047 homodimer interface [polypeptide binding]; other site 234621011048 catalytic residue [active] 234621011049 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 234621011050 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 234621011051 motif II; other site 234621011052 Low molecular weight phosphatase family; Region: LMWPc; cd00115 234621011053 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 234621011054 active site 234621011055 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 234621011056 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 234621011057 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 234621011058 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 234621011059 dimer interface [polypeptide binding]; other site 234621011060 catalytic triad [active] 234621011061 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 234621011062 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 234621011063 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 234621011064 dimer interface [polypeptide binding]; other site 234621011065 TPP-binding site [chemical binding]; other site 234621011066 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 234621011067 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 234621011068 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 234621011069 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 234621011070 acyl carrier protein; Provisional; Region: acpP; PRK00982 234621011071 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 234621011072 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 234621011073 dimer interface [polypeptide binding]; other site 234621011074 active site 234621011075 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 234621011076 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 234621011077 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 234621011078 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 234621011079 Beta-lactamase; Region: Beta-lactamase; pfam00144 234621011080 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 234621011081 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 234621011082 NAD binding site [chemical binding]; other site 234621011083 catalytic Zn binding site [ion binding]; other site 234621011084 substrate binding site [chemical binding]; other site 234621011085 structural Zn binding site [ion binding]; other site 234621011086 Domain of unknown function (DUF222); Region: DUF222; pfam02720 234621011087 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 234621011088 active site 234621011089 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 234621011090 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234621011091 active site 234621011092 phosphorylation site [posttranslational modification] 234621011093 intermolecular recognition site; other site 234621011094 dimerization interface [polypeptide binding]; other site 234621011095 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 234621011096 DNA binding residues [nucleotide binding] 234621011097 dimerization interface [polypeptide binding]; other site 234621011098 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 234621011099 Histidine kinase; Region: HisKA_3; pfam07730 234621011100 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234621011101 ATP binding site [chemical binding]; other site 234621011102 Mg2+ binding site [ion binding]; other site 234621011103 G-X-G motif; other site 234621011104 MMPL family; Region: MMPL; pfam03176 234621011105 MMPL family; Region: MMPL; pfam03176 234621011106 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 234621011107 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 234621011108 putative substrate binding site [chemical binding]; other site 234621011109 putative ATP binding site [chemical binding]; other site 234621011110 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 234621011111 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 234621011112 Walker A/P-loop; other site 234621011113 ATP binding site [chemical binding]; other site 234621011114 Q-loop/lid; other site 234621011115 ABC transporter signature motif; other site 234621011116 Walker B; other site 234621011117 D-loop; other site 234621011118 H-loop/switch region; other site 234621011119 TOBE domain; Region: TOBE_2; pfam08402 234621011120 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 234621011121 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234621011122 dimer interface [polypeptide binding]; other site 234621011123 conserved gate region; other site 234621011124 putative PBP binding loops; other site 234621011125 ABC-ATPase subunit interface; other site 234621011126 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234621011127 dimer interface [polypeptide binding]; other site 234621011128 conserved gate region; other site 234621011129 putative PBP binding loops; other site 234621011130 ABC-ATPase subunit interface; other site 234621011131 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 234621011132 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 234621011133 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234621011134 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 234621011135 DNA binding residues [nucleotide binding] 234621011136 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 234621011137 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 234621011138 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 234621011139 inhibitor binding site; inhibition site 234621011140 catalytic Zn binding site [ion binding]; other site 234621011141 structural Zn binding site [ion binding]; other site 234621011142 NADP binding site [chemical binding]; other site 234621011143 tetramer interface [polypeptide binding]; other site 234621011144 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 234621011145 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 234621011146 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 234621011147 DinB superfamily; Region: DinB_2; pfam12867 234621011148 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 234621011149 DNA primase; Validated; Region: dnaG; PRK05667 234621011150 CHC2 zinc finger; Region: zf-CHC2; pfam01807 234621011151 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 234621011152 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 234621011153 active site 234621011154 metal binding site [ion binding]; metal-binding site 234621011155 interdomain interaction site; other site 234621011156 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 234621011157 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 234621011158 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 234621011159 Catalytic domain of Protein Kinases; Region: PKc; cd00180 234621011160 active site 234621011161 ATP binding site [chemical binding]; other site 234621011162 substrate binding site [chemical binding]; other site 234621011163 activation loop (A-loop); other site 234621011164 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 234621011165 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 234621011166 Zn2+ binding site [ion binding]; other site 234621011167 Mg2+ binding site [ion binding]; other site 234621011168 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 234621011169 putative active site [active] 234621011170 Repair protein; Region: Repair_PSII; pfam04536 234621011171 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 234621011172 Ligand binding site; other site 234621011173 Putative Catalytic site; other site 234621011174 DXD motif; other site 234621011175 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 234621011176 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234621011177 non-specific DNA binding site [nucleotide binding]; other site 234621011178 salt bridge; other site 234621011179 sequence-specific DNA binding site [nucleotide binding]; other site 234621011180 SnoaL-like domain; Region: SnoaL_2; pfam12680 234621011181 MepB protein; Region: MepB; cl01985 234621011182 RibD C-terminal domain; Region: RibD_C; cl17279 234621011183 glycyl-tRNA synthetase; Provisional; Region: PRK04173 234621011184 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 234621011185 motif 1; other site 234621011186 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 234621011187 active site 234621011188 motif 2; other site 234621011189 motif 3; other site 234621011190 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 234621011191 anticodon binding site; other site 234621011192 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 234621011193 dimerization interface [polypeptide binding]; other site 234621011194 putative DNA binding site [nucleotide binding]; other site 234621011195 putative Zn2+ binding site [ion binding]; other site 234621011196 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 234621011197 metal binding site 2 [ion binding]; metal-binding site 234621011198 putative DNA binding helix; other site 234621011199 metal binding site 1 [ion binding]; metal-binding site 234621011200 dimer interface [polypeptide binding]; other site 234621011201 structural Zn2+ binding site [ion binding]; other site 234621011202 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 234621011203 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 234621011204 catalytic residue [active] 234621011205 putative FPP diphosphate binding site; other site 234621011206 putative FPP binding hydrophobic cleft; other site 234621011207 dimer interface [polypeptide binding]; other site 234621011208 putative IPP diphosphate binding site; other site 234621011209 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 234621011210 Recombination protein O N terminal; Region: RecO_N; pfam11967 234621011211 Recombination protein O C terminal; Region: RecO_C; pfam02565 234621011212 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621011213 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621011214 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 234621011215 DoxX-like family; Region: DoxX_2; pfam13564 234621011216 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642 234621011217 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621011218 NAD(P) binding site [chemical binding]; other site 234621011219 active site 234621011220 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 234621011221 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 234621011222 active site 234621011223 non-prolyl cis peptide bond; other site 234621011224 DNA polymerase IV; Validated; Region: PRK03858 234621011225 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 234621011226 active site 234621011227 DNA binding site [nucleotide binding] 234621011228 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 234621011229 MarR family; Region: MarR; pfam01047 234621011230 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 234621011231 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 234621011232 putative NAD(P) binding site [chemical binding]; other site 234621011233 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 234621011234 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234621011235 active site 234621011236 phosphorylation site [posttranslational modification] 234621011237 intermolecular recognition site; other site 234621011238 dimerization interface [polypeptide binding]; other site 234621011239 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 234621011240 DNA binding site [nucleotide binding] 234621011241 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 234621011242 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 234621011243 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 234621011244 Ligand Binding Site [chemical binding]; other site 234621011245 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234621011246 dimer interface [polypeptide binding]; other site 234621011247 phosphorylation site [posttranslational modification] 234621011248 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234621011249 ATP binding site [chemical binding]; other site 234621011250 Mg2+ binding site [ion binding]; other site 234621011251 G-X-G motif; other site 234621011252 K+-transporting ATPase, c chain; Region: KdpC; cl00944 234621011253 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 234621011254 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 234621011255 Soluble P-type ATPase [General function prediction only]; Region: COG4087 234621011256 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 234621011257 amidase; Provisional; Region: PRK06061 234621011258 Amidase; Region: Amidase; cl11426 234621011259 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621011260 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621011261 GTPase Era; Reviewed; Region: era; PRK00089 234621011262 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 234621011263 G1 box; other site 234621011264 GTP/Mg2+ binding site [chemical binding]; other site 234621011265 Switch I region; other site 234621011266 G2 box; other site 234621011267 Switch II region; other site 234621011268 G3 box; other site 234621011269 G4 box; other site 234621011270 G5 box; other site 234621011271 KH domain; Region: KH_2; pfam07650 234621011272 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 234621011273 Domain of unknown function DUF21; Region: DUF21; pfam01595 234621011274 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 234621011275 metal-binding heat shock protein; Provisional; Region: PRK00016 234621011276 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 234621011277 PhoH-like protein; Region: PhoH; pfam02562 234621011278 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621011279 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621011280 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 234621011281 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621011282 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 234621011283 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234621011284 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 234621011285 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 234621011286 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 234621011287 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 234621011288 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 234621011289 RNA methyltransferase, RsmE family; Region: TIGR00046 234621011290 chaperone protein DnaJ; Provisional; Region: PRK14278 234621011291 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 234621011292 HSP70 interaction site [polypeptide binding]; other site 234621011293 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 234621011294 Zn binding sites [ion binding]; other site 234621011295 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 234621011296 dimer interface [polypeptide binding]; other site 234621011297 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 234621011298 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 234621011299 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 234621011300 glycogen branching enzyme; Provisional; Region: PRK14705 234621011301 coproporphyrinogen III oxidase; Validated; Region: PRK05628 234621011302 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 234621011303 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 234621011304 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 234621011305 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 234621011306 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 234621011307 Active Sites [active] 234621011308 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 234621011309 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 234621011310 Active Sites [active] 234621011311 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 234621011312 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 234621011313 CysD dimerization site [polypeptide binding]; other site 234621011314 G1 box; other site 234621011315 putative GEF interaction site [polypeptide binding]; other site 234621011316 GTP/Mg2+ binding site [chemical binding]; other site 234621011317 Switch I region; other site 234621011318 G2 box; other site 234621011319 G3 box; other site 234621011320 Switch II region; other site 234621011321 G4 box; other site 234621011322 G5 box; other site 234621011323 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 234621011324 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 234621011325 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 234621011326 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 234621011327 putative active site [active] 234621011328 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 234621011329 putative active site [active] 234621011330 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 234621011331 Ligand Binding Site [chemical binding]; other site 234621011332 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 234621011333 Ligand Binding Site [chemical binding]; other site 234621011334 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 234621011335 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 234621011336 Walker A/P-loop; other site 234621011337 ATP binding site [chemical binding]; other site 234621011338 Q-loop/lid; other site 234621011339 ABC transporter signature motif; other site 234621011340 Walker B; other site 234621011341 D-loop; other site 234621011342 H-loop/switch region; other site 234621011343 TOBE-like domain; Region: TOBE_3; pfam12857 234621011344 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 234621011345 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234621011346 dimer interface [polypeptide binding]; other site 234621011347 conserved gate region; other site 234621011348 putative PBP binding loops; other site 234621011349 ABC-ATPase subunit interface; other site 234621011350 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 234621011351 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234621011352 dimer interface [polypeptide binding]; other site 234621011353 conserved gate region; other site 234621011354 putative PBP binding loops; other site 234621011355 ABC-ATPase subunit interface; other site 234621011356 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 234621011357 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 234621011358 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 234621011359 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 234621011360 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 234621011361 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 234621011362 intersubunit interface [polypeptide binding]; other site 234621011363 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 234621011364 FMN binding site [chemical binding]; other site 234621011365 substrate binding site [chemical binding]; other site 234621011366 putative catalytic residue [active] 234621011367 GTP-binding protein LepA; Provisional; Region: PRK05433 234621011368 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 234621011369 G1 box; other site 234621011370 putative GEF interaction site [polypeptide binding]; other site 234621011371 GTP/Mg2+ binding site [chemical binding]; other site 234621011372 Switch I region; other site 234621011373 G2 box; other site 234621011374 G3 box; other site 234621011375 Switch II region; other site 234621011376 G4 box; other site 234621011377 G5 box; other site 234621011378 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 234621011379 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 234621011380 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 234621011381 PemK-like protein; Region: PemK; pfam02452 234621011382 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 234621011383 amphipathic channel; other site 234621011384 Asn-Pro-Ala signature motifs; other site 234621011385 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 234621011386 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 234621011387 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 234621011388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 234621011389 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 234621011390 Uncharacterized conserved protein [Function unknown]; Region: COG2308 234621011391 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 234621011392 hypothetical protein; Reviewed; Region: PRK07914 234621011393 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 234621011394 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 234621011395 Competence protein; Region: Competence; pfam03772 234621011396 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 234621011397 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 234621011398 Helix-hairpin-helix motif; Region: HHH; pfam00633 234621011399 EDD domain protein, DegV family; Region: DegV; TIGR00762 234621011400 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 234621011401 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 234621011402 active site 234621011403 catalytic triad [active] 234621011404 oxyanion hole [active] 234621011405 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 234621011406 catalytic core [active] 234621011407 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 234621011408 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 234621011409 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 234621011410 active site 234621011411 (T/H)XGH motif; other site 234621011412 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 234621011413 metal ion-dependent adhesion site (MIDAS); other site 234621011414 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 234621011415 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234621011416 Walker A motif; other site 234621011417 ATP binding site [chemical binding]; other site 234621011418 Walker B motif; other site 234621011419 arginine finger; other site 234621011420 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 234621011421 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 234621011422 putative catalytic cysteine [active] 234621011423 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 234621011424 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 234621011425 active site 234621011426 FMN binding site [chemical binding]; other site 234621011427 substrate binding site [chemical binding]; other site 234621011428 homotetramer interface [polypeptide binding]; other site 234621011429 catalytic residue [active] 234621011430 proline/glycine betaine transporter; Provisional; Region: PRK10642 234621011431 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621011432 putative substrate translocation pore; other site 234621011433 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 234621011434 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 234621011435 substrate binding site [chemical binding]; other site 234621011436 dimer interface [polypeptide binding]; other site 234621011437 ATP binding site [chemical binding]; other site 234621011438 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 234621011439 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 234621011440 DNA binding residues [nucleotide binding] 234621011441 drug binding residues [chemical binding]; other site 234621011442 dimer interface [polypeptide binding]; other site 234621011443 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 234621011444 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 234621011445 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 234621011446 ATP binding site [chemical binding]; other site 234621011447 putative Mg++ binding site [ion binding]; other site 234621011448 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 234621011449 nucleotide binding region [chemical binding]; other site 234621011450 ATP-binding site [chemical binding]; other site 234621011451 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 234621011452 active site 234621011453 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 234621011454 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 234621011455 Coenzyme A binding pocket [chemical binding]; other site 234621011456 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 234621011457 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 234621011458 inhibitor-cofactor binding pocket; inhibition site 234621011459 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234621011460 catalytic residue [active] 234621011461 L-ectoine synthase; Reviewed; Region: ectC; PRK13290 234621011462 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159 234621011463 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 234621011464 putative ligand binding site [chemical binding]; other site 234621011465 putative NAD binding site [chemical binding]; other site 234621011466 catalytic site [active] 234621011467 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 234621011468 putative dimer interface [polypeptide binding]; other site 234621011469 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234621011470 NAD-dependent deacetylase; Provisional; Region: PRK05333 234621011471 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 234621011472 NAD+ binding site [chemical binding]; other site 234621011473 substrate binding site [chemical binding]; other site 234621011474 Zn binding site [ion binding]; other site 234621011475 gamma-glutamyl kinase; Provisional; Region: PRK05429 234621011476 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 234621011477 nucleotide binding site [chemical binding]; other site 234621011478 homotetrameric interface [polypeptide binding]; other site 234621011479 putative phosphate binding site [ion binding]; other site 234621011480 putative allosteric binding site; other site 234621011481 PUA domain; Region: PUA; pfam01472 234621011482 GTPase CgtA; Reviewed; Region: obgE; PRK12296 234621011483 GTP1/OBG; Region: GTP1_OBG; pfam01018 234621011484 Obg GTPase; Region: Obg; cd01898 234621011485 G1 box; other site 234621011486 GTP/Mg2+ binding site [chemical binding]; other site 234621011487 Switch I region; other site 234621011488 G2 box; other site 234621011489 G3 box; other site 234621011490 Switch II region; other site 234621011491 G4 box; other site 234621011492 G5 box; other site 234621011493 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 234621011494 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 234621011495 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 234621011496 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 234621011497 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 234621011498 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 234621011499 homodimer interface [polypeptide binding]; other site 234621011500 oligonucleotide binding site [chemical binding]; other site 234621011501 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 234621011502 active site 234621011503 multimer interface [polypeptide binding]; other site 234621011504 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 234621011505 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 234621011506 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 234621011507 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 234621011508 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 234621011509 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 234621011510 HIGH motif; other site 234621011511 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 234621011512 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 234621011513 active site 234621011514 KMSKS motif; other site 234621011515 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 234621011516 tRNA binding surface [nucleotide binding]; other site 234621011517 anticodon binding site; other site 234621011518 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 234621011519 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 234621011520 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234621011521 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 234621011522 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 234621011523 siderophore binding site; other site 234621011524 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 234621011525 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 234621011526 putative molybdopterin cofactor binding site [chemical binding]; other site 234621011527 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 234621011528 putative molybdopterin cofactor binding site; other site 234621011529 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 234621011530 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 234621011531 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 234621011532 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 234621011533 active site 234621011534 Fe binding site [ion binding]; other site 234621011535 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 234621011536 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 234621011537 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 234621011538 shikimate binding site; other site 234621011539 NAD(P) binding site [chemical binding]; other site 234621011540 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 234621011541 Dehydroquinase class II; Region: DHquinase_II; pfam01220 234621011542 active site 234621011543 trimer interface [polypeptide binding]; other site 234621011544 dimer interface [polypeptide binding]; other site 234621011545 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621011546 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621011547 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 234621011548 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 234621011549 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 234621011550 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 234621011551 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621011552 metabolite-proton symporter; Region: 2A0106; TIGR00883 234621011553 putative substrate translocation pore; other site 234621011554 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 234621011555 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 234621011556 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234621011557 Walker A motif; other site 234621011558 ATP binding site [chemical binding]; other site 234621011559 Walker B motif; other site 234621011560 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 234621011561 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 234621011562 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 234621011563 oligomer interface [polypeptide binding]; other site 234621011564 active site residues [active] 234621011565 Clp protease; Region: CLP_protease; pfam00574 234621011566 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 234621011567 oligomer interface [polypeptide binding]; other site 234621011568 active site residues [active] 234621011569 trigger factor; Provisional; Region: tig; PRK01490 234621011570 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 234621011571 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 234621011572 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 234621011573 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 234621011574 putative DNA binding site [nucleotide binding]; other site 234621011575 catalytic residue [active] 234621011576 putative H2TH interface [polypeptide binding]; other site 234621011577 putative catalytic residues [active] 234621011578 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 234621011579 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 234621011580 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 234621011581 Peptidase family M48; Region: Peptidase_M48; pfam01435 234621011582 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 234621011583 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 234621011584 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 234621011585 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 234621011586 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 234621011587 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 234621011588 Repair protein; Region: Repair_PSII; pfam04536 234621011589 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 234621011590 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 234621011591 active site 234621011592 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 234621011593 apolar tunnel; other site 234621011594 heme binding site [chemical binding]; other site 234621011595 dimerization interface [polypeptide binding]; other site 234621011596 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 234621011597 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 234621011598 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 234621011599 active site 234621011600 catalytic site [active] 234621011601 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 234621011602 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 234621011603 active site 234621011604 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 234621011605 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 234621011606 active site 234621011607 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 234621011608 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234621011609 Walker A/P-loop; other site 234621011610 ATP binding site [chemical binding]; other site 234621011611 Q-loop/lid; other site 234621011612 ABC transporter signature motif; other site 234621011613 Walker B; other site 234621011614 D-loop; other site 234621011615 H-loop/switch region; other site 234621011616 ABC transporter; Region: ABC_tran_2; pfam12848 234621011617 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 234621011618 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621011619 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621011620 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 234621011621 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 234621011622 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234621011623 Walker A/P-loop; other site 234621011624 ATP binding site [chemical binding]; other site 234621011625 Q-loop/lid; other site 234621011626 ABC transporter signature motif; other site 234621011627 Walker B; other site 234621011628 D-loop; other site 234621011629 H-loop/switch region; other site 234621011630 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 234621011631 MarR family; Region: MarR; pfam01047 234621011632 MarR family; Region: MarR_2; cl17246 234621011633 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 234621011634 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 234621011635 dimer interface [polypeptide binding]; other site 234621011636 ssDNA binding site [nucleotide binding]; other site 234621011637 tetramer (dimer of dimers) interface [polypeptide binding]; other site 234621011638 Copper resistance protein D; Region: CopD; pfam05425 234621011639 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 234621011640 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 234621011641 active site 234621011642 catalytic site [active] 234621011643 Uncharacterized conserved protein [Function unknown]; Region: COG1359 234621011644 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 234621011645 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 234621011646 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 234621011647 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 234621011648 glutamate dehydrogenase; Provisional; Region: PRK09414 234621011649 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 234621011650 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 234621011651 NAD(P) binding site [chemical binding]; other site 234621011652 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 234621011653 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 234621011654 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 234621011655 putative di-iron ligands [ion binding]; other site 234621011656 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 234621011657 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 234621011658 FAD binding pocket [chemical binding]; other site 234621011659 FAD binding motif [chemical binding]; other site 234621011660 phosphate binding motif [ion binding]; other site 234621011661 beta-alpha-beta structure motif; other site 234621011662 NAD binding pocket [chemical binding]; other site 234621011663 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 234621011664 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 234621011665 catalytic loop [active] 234621011666 iron binding site [ion binding]; other site 234621011667 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 234621011668 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621011669 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 234621011670 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 234621011671 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 234621011672 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 234621011673 active site 2 [active] 234621011674 active site 1 [active] 234621011675 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II; cd00556 234621011676 active site 234621011677 dimer interface [polypeptide binding]; other site 234621011678 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 234621011679 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621011680 Predicted transcriptional regulators [Transcription]; Region: COG1695 234621011681 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 234621011682 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 234621011683 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 234621011684 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 234621011685 active site 234621011686 FMN binding site [chemical binding]; other site 234621011687 2,4-decadienoyl-CoA binding site; other site 234621011688 catalytic residue [active] 234621011689 4Fe-4S cluster binding site [ion binding]; other site 234621011690 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 234621011691 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 234621011692 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 234621011693 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621011694 NAD(P) binding site [chemical binding]; other site 234621011695 active site 234621011696 diaminopimelate decarboxylase; Region: lysA; TIGR01048 234621011697 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 234621011698 active site 234621011699 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 234621011700 substrate binding site [chemical binding]; other site 234621011701 catalytic residues [active] 234621011702 dimer interface [polypeptide binding]; other site 234621011703 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 234621011704 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 234621011705 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 234621011706 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 234621011707 catalytic site [active] 234621011708 putative active site [active] 234621011709 putative substrate binding site [chemical binding]; other site 234621011710 dimer interface [polypeptide binding]; other site 234621011711 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 234621011712 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 234621011713 DNA binding residues [nucleotide binding] 234621011714 putative dimer interface [polypeptide binding]; other site 234621011715 oxidoreductase; Provisional; Region: PRK06196 234621011716 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 234621011717 putative NAD(P) binding site [chemical binding]; other site 234621011718 active site 234621011719 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 234621011720 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 234621011721 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 234621011722 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 234621011723 amidase; Provisional; Region: PRK12470 234621011724 Amidase; Region: Amidase; pfam01425 234621011725 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 234621011726 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 234621011727 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 234621011728 catalytic triad [active] 234621011729 hypothetical protein; Provisional; Region: PRK07907 234621011730 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 234621011731 active site 234621011732 metal binding site [ion binding]; metal-binding site 234621011733 dimer interface [polypeptide binding]; other site 234621011734 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621011735 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621011736 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 234621011737 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 234621011738 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 234621011739 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 234621011740 phosphate binding site [ion binding]; other site 234621011741 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 234621011742 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 234621011743 active site 2 [active] 234621011744 active site 1 [active] 234621011745 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 234621011746 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 234621011747 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 234621011748 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 234621011749 putative NAD(P) binding site [chemical binding]; other site 234621011750 active site 234621011751 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 234621011752 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 234621011753 active site 234621011754 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 234621011755 Glucitol operon activator protein (GutM); Region: GutM; cl01890 234621011756 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 234621011757 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 234621011758 active site 234621011759 dimerization interface [polypeptide binding]; other site 234621011760 ribonuclease PH; Reviewed; Region: rph; PRK00173 234621011761 Ribonuclease PH; Region: RNase_PH_bact; cd11362 234621011762 hexamer interface [polypeptide binding]; other site 234621011763 active site 234621011764 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 234621011765 Rhomboid family; Region: Rhomboid; pfam01694 234621011766 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 234621011767 putative active site pocket [active] 234621011768 cleavage site 234621011769 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 234621011770 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 234621011771 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 234621011772 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 234621011773 active site 234621011774 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 234621011775 Isochorismatase family; Region: Isochorismatase; pfam00857 234621011776 catalytic triad [active] 234621011777 metal binding site [ion binding]; metal-binding site 234621011778 conserved cis-peptide bond; other site 234621011779 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 234621011780 DEAD/DEAH box helicase; Region: DEAD; pfam00270 234621011781 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 234621011782 putative Mg++ binding site [ion binding]; other site 234621011783 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 234621011784 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 234621011785 putative homodimer interface [polypeptide binding]; other site 234621011786 putative active site pocket [active] 234621011787 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 234621011788 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 234621011789 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 234621011790 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 234621011791 active site 234621011792 homodimer interface [polypeptide binding]; other site 234621011793 catalytic site [active] 234621011794 acceptor binding site [chemical binding]; other site 234621011795 glycogen branching enzyme; Provisional; Region: PRK05402 234621011796 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 234621011797 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 234621011798 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 234621011799 active site 234621011800 catalytic site [active] 234621011801 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 234621011802 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 234621011803 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 234621011804 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 234621011805 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 234621011806 putative acyltransferase; Provisional; Region: PRK05790 234621011807 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 234621011808 dimer interface [polypeptide binding]; other site 234621011809 active site 234621011810 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 234621011811 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234621011812 dimer interface [polypeptide binding]; other site 234621011813 substrate binding site [chemical binding]; other site 234621011814 metal binding site [ion binding]; metal-binding site 234621011815 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 234621011816 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 234621011817 hypothetical protein; Provisional; Region: PRK03298 234621011818 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 234621011819 dimerization interface [polypeptide binding]; other site 234621011820 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 234621011821 cyclase homology domain; Region: CHD; cd07302 234621011822 nucleotidyl binding site; other site 234621011823 metal binding site [ion binding]; metal-binding site 234621011824 dimer interface [polypeptide binding]; other site 234621011825 RibD C-terminal domain; Region: RibD_C; cl17279 234621011826 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 234621011827 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 234621011828 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 234621011829 hinge; other site 234621011830 active site 234621011831 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 234621011832 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 234621011833 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 234621011834 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 234621011835 gamma subunit interface [polypeptide binding]; other site 234621011836 epsilon subunit interface [polypeptide binding]; other site 234621011837 LBP interface [polypeptide binding]; other site 234621011838 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 234621011839 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 234621011840 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 234621011841 alpha subunit interaction interface [polypeptide binding]; other site 234621011842 Walker A motif; other site 234621011843 ATP binding site [chemical binding]; other site 234621011844 Walker B motif; other site 234621011845 inhibitor binding site; inhibition site 234621011846 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 234621011847 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 234621011848 core domain interface [polypeptide binding]; other site 234621011849 delta subunit interface [polypeptide binding]; other site 234621011850 epsilon subunit interface [polypeptide binding]; other site 234621011851 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 234621011852 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 234621011853 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 234621011854 beta subunit interaction interface [polypeptide binding]; other site 234621011855 Walker A motif; other site 234621011856 ATP binding site [chemical binding]; other site 234621011857 Walker B motif; other site 234621011858 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 234621011859 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 234621011860 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 234621011861 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 234621011862 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 234621011863 F0F1 ATP synthase subunit C; Validated; Region: PRK07874 234621011864 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 234621011865 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 234621011866 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 234621011867 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 234621011868 Mg++ binding site [ion binding]; other site 234621011869 putative catalytic motif [active] 234621011870 substrate binding site [chemical binding]; other site 234621011871 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 234621011872 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 234621011873 dimer interface [polypeptide binding]; other site 234621011874 active site 234621011875 glycine-pyridoxal phosphate binding site [chemical binding]; other site 234621011876 folate binding site [chemical binding]; other site 234621011877 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 234621011878 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 234621011879 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234621011880 S-adenosylmethionine binding site [chemical binding]; other site 234621011881 peptide chain release factor 1; Validated; Region: prfA; PRK00591 234621011882 This domain is found in peptide chain release factors; Region: PCRF; smart00937 234621011883 RF-1 domain; Region: RF-1; pfam00472 234621011884 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 234621011885 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 234621011886 transcription termination factor Rho; Provisional; Region: PRK12608 234621011887 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 234621011888 RNA binding site [nucleotide binding]; other site 234621011889 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 234621011890 multimer interface [polypeptide binding]; other site 234621011891 Walker A motif; other site 234621011892 ATP binding site [chemical binding]; other site 234621011893 Walker B motif; other site 234621011894 homoserine kinase; Provisional; Region: PRK01212 234621011895 threonine synthase; Reviewed; Region: PRK06721 234621011896 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 234621011897 homodimer interface [polypeptide binding]; other site 234621011898 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234621011899 catalytic residue [active] 234621011900 homoserine dehydrogenase; Provisional; Region: PRK06349 234621011901 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 234621011902 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 234621011903 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 234621011904 diaminopimelate decarboxylase; Region: lysA; TIGR01048 234621011905 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 234621011906 active site 234621011907 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 234621011908 substrate binding site [chemical binding]; other site 234621011909 catalytic residues [active] 234621011910 dimer interface [polypeptide binding]; other site 234621011911 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 234621011912 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 234621011913 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 234621011914 active site 234621011915 HIGH motif; other site 234621011916 KMSK motif region; other site 234621011917 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 234621011918 tRNA binding surface [nucleotide binding]; other site 234621011919 anticodon binding site; other site 234621011920 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 234621011921 Domain of unknown function (DUF305); Region: DUF305; pfam03713 234621011922 putative phosphoketolase; Provisional; Region: PRK05261 234621011923 XFP N-terminal domain; Region: XFP_N; pfam09364 234621011924 XFP C-terminal domain; Region: XFP_C; pfam09363 234621011925 Transcriptional regulator [Transcription]; Region: LysR; COG0583 234621011926 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 234621011927 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 234621011928 putative substrate binding pocket [chemical binding]; other site 234621011929 dimerization interface [polypeptide binding]; other site 234621011930 metabolite-proton symporter; Region: 2A0106; TIGR00883 234621011931 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621011932 putative substrate translocation pore; other site 234621011933 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 234621011934 hypothetical protein; Provisional; Region: PRK06126 234621011935 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 234621011936 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621011937 Major Facilitator Superfamily; Region: MFS_1; pfam07690 234621011938 putative substrate translocation pore; other site 234621011939 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621011940 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 234621011941 MarR family; Region: MarR_2; pfam12802 234621011942 N(5)-(carboxyethyl)ornithine synthase; Region: ceo_syn; cd12181 234621011943 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 234621011944 putative active site [active] 234621011945 putative ligand binding site [chemical binding]; other site 234621011946 putative NAD(P) binding site [chemical binding]; other site 234621011947 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 234621011948 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 234621011949 active site 234621011950 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 234621011951 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 234621011952 CysD dimerization site [polypeptide binding]; other site 234621011953 G1 box; other site 234621011954 putative GEF interaction site [polypeptide binding]; other site 234621011955 GTP/Mg2+ binding site [chemical binding]; other site 234621011956 Switch I region; other site 234621011957 G2 box; other site 234621011958 G3 box; other site 234621011959 Switch II region; other site 234621011960 G4 box; other site 234621011961 G5 box; other site 234621011962 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 234621011963 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 234621011964 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 234621011965 ligand-binding site [chemical binding]; other site 234621011966 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 234621011967 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 234621011968 Active Sites [active] 234621011969 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 234621011970 short chain dehydrogenase; Provisional; Region: PRK07890 234621011971 classical (c) SDRs; Region: SDR_c; cd05233 234621011972 NAD(P) binding site [chemical binding]; other site 234621011973 active site 234621011974 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 234621011975 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 234621011976 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 234621011977 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 234621011978 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234621011979 active site 234621011980 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234621011981 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621011982 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621011983 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234621011984 non-specific DNA binding site [nucleotide binding]; other site 234621011985 salt bridge; other site 234621011986 sequence-specific DNA binding site [nucleotide binding]; other site 234621011987 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 234621011988 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 234621011989 cofactor binding site; other site 234621011990 DNA binding site [nucleotide binding] 234621011991 substrate interaction site [chemical binding]; other site 234621011992 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 234621011993 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621011994 putative substrate translocation pore; other site 234621011995 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 234621011996 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 234621011997 Mg++ binding site [ion binding]; other site 234621011998 putative catalytic motif [active] 234621011999 putative substrate binding site [chemical binding]; other site 234621012000 Transcriptional regulators [Transcription]; Region: MarR; COG1846 234621012001 MarR family; Region: MarR; pfam01047 234621012002 enoyl-CoA hydratase; Provisional; Region: PRK05862 234621012003 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 234621012004 substrate binding site [chemical binding]; other site 234621012005 oxyanion hole (OAH) forming residues; other site 234621012006 trimer interface [polypeptide binding]; other site 234621012007 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 234621012008 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 234621012009 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 234621012010 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 234621012011 substrate binding site [chemical binding]; other site 234621012012 oxyanion hole (OAH) forming residues; other site 234621012013 trimer interface [polypeptide binding]; other site 234621012014 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 234621012015 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621012016 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 234621012017 substrate binding pocket [chemical binding]; other site 234621012018 FAD binding site [chemical binding]; other site 234621012019 catalytic base [active] 234621012020 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 234621012021 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 234621012022 tetrameric interface [polypeptide binding]; other site 234621012023 NAD binding site [chemical binding]; other site 234621012024 catalytic residues [active] 234621012025 CutC family; Region: CutC; cl01218 234621012026 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 234621012027 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 234621012028 active site 234621012029 trimer interface [polypeptide binding]; other site 234621012030 allosteric site; other site 234621012031 active site lid [active] 234621012032 hexamer (dimer of trimers) interface [polypeptide binding]; other site 234621012033 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 234621012034 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234621012035 active site 234621012036 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 234621012037 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 234621012038 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 234621012039 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 234621012040 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 234621012041 dimerization domain swap beta strand [polypeptide binding]; other site 234621012042 regulatory protein interface [polypeptide binding]; other site 234621012043 active site 234621012044 regulatory phosphorylation site [posttranslational modification]; other site 234621012045 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 234621012046 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 234621012047 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 234621012048 active site turn [active] 234621012049 phosphorylation site [posttranslational modification] 234621012050 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 234621012051 HPr interaction site; other site 234621012052 glycerol kinase (GK) interaction site [polypeptide binding]; other site 234621012053 active site 234621012054 phosphorylation site [posttranslational modification] 234621012055 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 234621012056 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 234621012057 DNA-binding site [nucleotide binding]; DNA binding site 234621012058 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 234621012059 Uncharacterized conserved protein [Function unknown]; Region: COG4279 234621012060 SWIM zinc finger; Region: SWIM; pfam04434 234621012061 SNF2 Helicase protein; Region: DUF3670; pfam12419 234621012062 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 234621012063 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 234621012064 ATP binding site [chemical binding]; other site 234621012065 putative Mg++ binding site [ion binding]; other site 234621012066 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 234621012067 nucleotide binding region [chemical binding]; other site 234621012068 ATP-binding site [chemical binding]; other site 234621012069 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234621012070 LIM is a small protein-protein interaction domain, containing two zinc fingers; Region: LIM; cl02475 234621012071 Zn binding site [ion binding]; other site 234621012072 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 234621012073 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 234621012074 Phage capsid family; Region: Phage_capsid; pfam05065 234621012075 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 234621012076 active site 234621012077 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 234621012078 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 234621012079 catalytic residues [active] 234621012080 catalytic nucleophile [active] 234621012081 Recombinase; Region: Recombinase; pfam07508 234621012082 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 234621012083 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 234621012084 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 234621012085 putative NAD(P) binding site [chemical binding]; other site 234621012086 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 234621012087 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234621012088 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 234621012089 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 234621012090 active site 234621012091 tetracycline repressor protein TetR; Provisional; Region: PRK13756 234621012092 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621012093 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 234621012094 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 234621012095 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 234621012096 Moco binding site; other site 234621012097 metal coordination site [ion binding]; other site 234621012098 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 234621012099 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 234621012100 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 234621012101 shikimate binding site; other site 234621012102 NAD(P) binding site [chemical binding]; other site 234621012103 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 234621012104 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 234621012105 active site residue [active] 234621012106 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 234621012107 active site residue [active] 234621012108 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 234621012109 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 234621012110 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 234621012111 AsnC family; Region: AsnC_trans_reg; pfam01037 234621012112 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 234621012113 benzoate transporter; Region: benE; TIGR00843 234621012114 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 234621012115 active site 234621012116 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 234621012117 putative active site [active] 234621012118 putative substrate binding site [chemical binding]; other site 234621012119 ATP binding site [chemical binding]; other site 234621012120 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 234621012121 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 234621012122 TPP-binding site [chemical binding]; other site 234621012123 heterodimer interface [polypeptide binding]; other site 234621012124 tetramer interface [polypeptide binding]; other site 234621012125 phosphorylation loop region [posttranslational modification] 234621012126 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 234621012127 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 234621012128 alpha subunit interface [polypeptide binding]; other site 234621012129 TPP binding site [chemical binding]; other site 234621012130 heterodimer interface [polypeptide binding]; other site 234621012131 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 234621012132 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 234621012133 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 234621012134 E3 interaction surface; other site 234621012135 lipoyl attachment site [posttranslational modification]; other site 234621012136 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 234621012137 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621012138 Major Facilitator Superfamily; Region: MFS_1; pfam07690 234621012139 putative substrate translocation pore; other site 234621012140 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 234621012141 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 234621012142 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 234621012143 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 234621012144 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 234621012145 ligand binding site [chemical binding]; other site 234621012146 homodimer interface [polypeptide binding]; other site 234621012147 NAD(P) binding site [chemical binding]; other site 234621012148 trimer interface B [polypeptide binding]; other site 234621012149 trimer interface A [polypeptide binding]; other site 234621012150 Protein of unknown function, DUF488; Region: DUF488; cl01246 234621012151 acyl-CoA synthetase; Provisional; Region: PRK13391 234621012152 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621012153 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 234621012154 acyl-activating enzyme (AAE) consensus motif; other site 234621012155 putative AMP binding site [chemical binding]; other site 234621012156 putative active site [active] 234621012157 acyl-activating enzyme (AAE) consensus motif; other site 234621012158 putative CoA binding site [chemical binding]; other site 234621012159 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 234621012160 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 234621012161 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129 234621012162 catalytic triad [active] 234621012163 active site nucleophile [active] 234621012164 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 234621012165 Coenzyme A binding pocket [chemical binding]; other site 234621012166 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621012167 H+ Antiporter protein; Region: 2A0121; TIGR00900 234621012168 putative substrate translocation pore; other site 234621012169 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 234621012170 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 234621012171 substrate binding pocket [chemical binding]; other site 234621012172 catalytic triad [active] 234621012173 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 234621012174 NMT1/THI5 like; Region: NMT1; pfam09084 234621012175 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 234621012176 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234621012177 dimer interface [polypeptide binding]; other site 234621012178 conserved gate region; other site 234621012179 putative PBP binding loops; other site 234621012180 ABC-ATPase subunit interface; other site 234621012181 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 234621012182 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 234621012183 Walker A/P-loop; other site 234621012184 ATP binding site [chemical binding]; other site 234621012185 Q-loop/lid; other site 234621012186 ABC transporter signature motif; other site 234621012187 Walker B; other site 234621012188 D-loop; other site 234621012189 H-loop/switch region; other site 234621012190 Bulb-type mannose-specific lectin; Region: B_lectin; smart00108 234621012191 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 234621012192 dimerization interface [polypeptide binding]; other site 234621012193 mannose binding site [chemical binding]; other site 234621012194 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 234621012195 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 234621012196 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 234621012197 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234621012198 S-adenosylmethionine binding site [chemical binding]; other site 234621012199 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 234621012200 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 234621012201 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 234621012202 NAD binding site [chemical binding]; other site 234621012203 Phe binding site; other site 234621012204 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 234621012205 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 234621012206 putative DNA binding site [nucleotide binding]; other site 234621012207 putative Zn2+ binding site [ion binding]; other site 234621012208 AsnC family; Region: AsnC_trans_reg; pfam01037 234621012209 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-II; Region: Lumazine_synthase-II; cd09208 234621012210 active site 234621012211 homopentamer interface [polypeptide binding]; other site 234621012212 dimer interface [polypeptide binding]; other site 234621012213 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 234621012214 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234621012215 active site 234621012216 phosphorylation site [posttranslational modification] 234621012217 intermolecular recognition site; other site 234621012218 dimerization interface [polypeptide binding]; other site 234621012219 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 234621012220 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 234621012221 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 234621012222 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 234621012223 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 234621012224 ligand binding site [chemical binding]; other site 234621012225 flexible hinge region; other site 234621012226 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234621012227 ATP binding site [chemical binding]; other site 234621012228 Mg2+ binding site [ion binding]; other site 234621012229 G-X-G motif; other site 234621012230 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 234621012231 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 234621012232 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 234621012233 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 234621012234 putative NAD(P) binding site [chemical binding]; other site 234621012235 catalytic Zn binding site [ion binding]; other site 234621012236 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 234621012237 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 234621012238 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 234621012239 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 234621012240 DNA binding residues [nucleotide binding] 234621012241 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 234621012242 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 234621012243 acyl-activating enzyme (AAE) consensus motif; other site 234621012244 putative AMP binding site [chemical binding]; other site 234621012245 putative active site [active] 234621012246 putative CoA binding site [chemical binding]; other site 234621012247 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 234621012248 MarR family; Region: MarR_2; pfam12802 234621012249 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 234621012250 Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Region: SLC5sbd_DUR3; cd11476 234621012251 Na binding site [ion binding]; other site 234621012252 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 234621012253 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 234621012254 active site 234621012255 ATP binding site [chemical binding]; other site 234621012256 substrate binding site [chemical binding]; other site 234621012257 activation loop (A-loop); other site 234621012258 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 234621012259 Integrase core domain; Region: rve; pfam00665 234621012260 transposase/IS protein; Provisional; Region: PRK09183 234621012261 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234621012262 Walker A motif; other site 234621012263 ATP binding site [chemical binding]; other site 234621012264 Walker B motif; other site 234621012265 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 234621012266 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 234621012267 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 234621012268 metal ion-dependent adhesion site (MIDAS); other site 234621012269 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234621012270 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 234621012271 Walker A motif; other site 234621012272 ATP binding site [chemical binding]; other site 234621012273 Walker B motif; other site 234621012274 Uncharacterized conserved protein [Function unknown]; Region: COG3410 234621012275 HNH endonuclease; Region: HNH_2; pfam13391 234621012276 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 234621012277 HNH endonuclease; Region: HNH_2; pfam13391 234621012278 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 234621012279 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 234621012280 P-loop; other site 234621012281 Magnesium ion binding site [ion binding]; other site 234621012282 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 234621012283 Magnesium ion binding site [ion binding]; other site 234621012284 Z1 domain; Region: Z1; pfam10593 234621012285 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234621012286 ATP binding site [chemical binding]; other site 234621012287 Mg2+ binding site [ion binding]; other site 234621012288 G-X-G motif; other site 234621012289 RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500 234621012290 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 234621012291 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 234621012292 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 234621012293 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 234621012294 Ligand Binding Site [chemical binding]; other site 234621012295 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 234621012296 Ligand Binding Site [chemical binding]; other site 234621012297 amino acid transporter; Region: 2A0306; TIGR00909 234621012298 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 234621012299 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 234621012300 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 234621012301 active site 234621012302 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 234621012303 dimer interface [polypeptide binding]; other site 234621012304 substrate binding site [chemical binding]; other site 234621012305 catalytic residue [active] 234621012306 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 234621012307 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 234621012308 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 234621012309 SnoaL-like domain; Region: SnoaL_4; pfam13577 234621012310 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 234621012311 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 234621012312 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 234621012313 active site 234621012314 non-prolyl cis peptide bond; other site 234621012315 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 234621012316 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 234621012317 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 234621012318 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 234621012319 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 234621012320 active site 234621012321 metal binding site [ion binding]; metal-binding site 234621012322 hexamer interface [polypeptide binding]; other site 234621012323 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 234621012324 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 234621012325 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 234621012326 Putative esterase; Region: Esterase; pfam00756 234621012327 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 234621012328 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 234621012329 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 234621012330 ATP binding site [chemical binding]; other site 234621012331 putative Mg++ binding site [ion binding]; other site 234621012332 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 234621012333 nucleotide binding region [chemical binding]; other site 234621012334 ATP-binding site [chemical binding]; other site 234621012335 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 234621012336 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 234621012337 putative metal binding site [ion binding]; other site 234621012338 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 234621012339 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234621012340 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 234621012341 RNA polymerase factor sigma-70; Validated; Region: PRK08241 234621012342 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234621012343 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234621012344 DNA binding residues [nucleotide binding] 234621012345 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 234621012346 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 234621012347 Coenzyme A binding pocket [chemical binding]; other site 234621012348 HD domain; Region: HD_4; pfam13328 234621012349 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 234621012350 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 234621012351 ATP-grasp domain; Region: ATP-grasp_4; cl17255 234621012352 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 234621012353 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 234621012354 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 234621012355 carboxyltransferase (CT) interaction site; other site 234621012356 biotinylation site [posttranslational modification]; other site 234621012357 Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326 234621012358 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 234621012359 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 234621012360 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 234621012361 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 234621012362 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 234621012363 motif II; other site 234621012364 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 234621012365 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 234621012366 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 234621012367 active site 234621012368 catalytic tetrad [active] 234621012369 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 234621012370 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 234621012371 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 234621012372 active site 234621012373 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 234621012374 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621012375 active site 234621012376 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 234621012377 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234621012378 FtsX-like permease family; Region: FtsX; pfam02687 234621012379 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234621012380 FtsX-like permease family; Region: FtsX; pfam02687 234621012381 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 234621012382 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 234621012383 Walker A/P-loop; other site 234621012384 ATP binding site [chemical binding]; other site 234621012385 Q-loop/lid; other site 234621012386 ABC transporter signature motif; other site 234621012387 Walker B; other site 234621012388 D-loop; other site 234621012389 H-loop/switch region; other site 234621012390 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 234621012391 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621012392 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 234621012393 acyl-activating enzyme (AAE) consensus motif; other site 234621012394 acyl-activating enzyme (AAE) consensus motif; other site 234621012395 putative AMP binding site [chemical binding]; other site 234621012396 putative active site [active] 234621012397 putative CoA binding site [chemical binding]; other site 234621012398 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 234621012399 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 234621012400 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234621012401 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 234621012402 Walker A/P-loop; other site 234621012403 ATP binding site [chemical binding]; other site 234621012404 Q-loop/lid; other site 234621012405 ABC transporter signature motif; other site 234621012406 Walker B; other site 234621012407 D-loop; other site 234621012408 H-loop/switch region; other site 234621012409 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 234621012410 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 234621012411 ATP binding site [chemical binding]; other site 234621012412 Mg++ binding site [ion binding]; other site 234621012413 motif III; other site 234621012414 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 234621012415 nucleotide binding region [chemical binding]; other site 234621012416 ATP-binding site [chemical binding]; other site 234621012417 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 234621012418 putative RNA binding site [nucleotide binding]; other site 234621012419 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 234621012420 Predicted amidohydrolase [General function prediction only]; Region: COG0388 234621012421 putative active site [active] 234621012422 catalytic triad [active] 234621012423 putative dimer interface [polypeptide binding]; other site 234621012424 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 234621012425 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 234621012426 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 234621012427 acyl-activating enzyme (AAE) consensus motif; other site 234621012428 putative AMP binding site [chemical binding]; other site 234621012429 putative active site [active] 234621012430 putative CoA binding site [chemical binding]; other site 234621012431 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 234621012432 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621012433 NAD(P) binding site [chemical binding]; other site 234621012434 active site 234621012435 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 234621012436 FAD binding domain; Region: FAD_binding_4; pfam01565 234621012437 Transcriptional regulators [Transcription]; Region: FadR; COG2186 234621012438 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 234621012439 DNA-binding site [nucleotide binding]; DNA binding site 234621012440 FCD domain; Region: FCD; pfam07729 234621012441 Isochorismatase family; Region: Isochorismatase; pfam00857 234621012442 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 234621012443 catalytic triad [active] 234621012444 conserved cis-peptide bond; other site 234621012445 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 234621012446 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 234621012447 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 234621012448 RNase_H superfamily; Region: RNase_H_2; pfam13482 234621012449 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 234621012450 Part of AAA domain; Region: AAA_19; pfam13245 234621012451 AAA domain; Region: AAA_12; pfam13087 234621012452 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 234621012453 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 234621012454 dimer interface [polypeptide binding]; other site 234621012455 active site 234621012456 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 234621012457 substrate binding site [chemical binding]; other site 234621012458 catalytic residue [active] 234621012459 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621012460 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 234621012461 FAD binding domain; Region: FAD_binding_4; pfam01565 234621012462 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 234621012463 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 234621012464 adenosine deaminase; Provisional; Region: PRK09358 234621012465 active site 234621012466 enoyl-CoA hydratase; Provisional; Region: PRK08252 234621012467 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 234621012468 substrate binding site [chemical binding]; other site 234621012469 oxyanion hole (OAH) forming residues; other site 234621012470 trimer interface [polypeptide binding]; other site 234621012471 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621012472 AMP-binding enzyme; Region: AMP-binding; pfam00501 234621012473 acyl-activating enzyme (AAE) consensus motif; other site 234621012474 active site 234621012475 AMP binding site [chemical binding]; other site 234621012476 CoA binding site [chemical binding]; other site 234621012477 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 234621012478 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 234621012479 substrate binding site [chemical binding]; other site 234621012480 oxyanion hole (OAH) forming residues; other site 234621012481 trimer interface [polypeptide binding]; other site 234621012482 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 234621012483 FAD binding domain; Region: FAD_binding_4; pfam01565 234621012484 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621012485 Major Facilitator Superfamily; Region: MFS_1; pfam07690 234621012486 putative substrate translocation pore; other site 234621012487 Predicted transcriptional regulators [Transcription]; Region: COG1695 234621012488 Transcriptional regulator PadR-like family; Region: PadR; cl17335 234621012489 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 234621012490 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 234621012491 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 234621012492 putative dimer interface [polypeptide binding]; other site 234621012493 N-terminal domain interface [polypeptide binding]; other site 234621012494 putative substrate binding pocket (H-site) [chemical binding]; other site 234621012495 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 234621012496 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234621012497 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 234621012498 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234621012499 Walker A/P-loop; other site 234621012500 ATP binding site [chemical binding]; other site 234621012501 Q-loop/lid; other site 234621012502 ABC transporter signature motif; other site 234621012503 Walker B; other site 234621012504 D-loop; other site 234621012505 H-loop/switch region; other site 234621012506 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 234621012507 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 234621012508 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234621012509 Walker A/P-loop; other site 234621012510 ATP binding site [chemical binding]; other site 234621012511 Q-loop/lid; other site 234621012512 ABC transporter signature motif; other site 234621012513 Walker B; other site 234621012514 D-loop; other site 234621012515 H-loop/switch region; other site 234621012516 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 234621012517 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 234621012518 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234621012519 Walker A/P-loop; other site 234621012520 ATP binding site [chemical binding]; other site 234621012521 Q-loop/lid; other site 234621012522 ABC transporter signature motif; other site 234621012523 Walker B; other site 234621012524 D-loop; other site 234621012525 H-loop/switch region; other site 234621012526 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 234621012527 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 234621012528 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 234621012529 TPP-binding site [chemical binding]; other site 234621012530 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 234621012531 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621012532 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621012533 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 234621012534 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 234621012535 short chain dehydrogenase; Provisional; Region: PRK07832 234621012536 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621012537 NAD(P) binding site [chemical binding]; other site 234621012538 active site 234621012539 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 234621012540 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 234621012541 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 234621012542 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 234621012543 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 234621012544 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 234621012545 Walker A/P-loop; other site 234621012546 ATP binding site [chemical binding]; other site 234621012547 Q-loop/lid; other site 234621012548 ABC transporter signature motif; other site 234621012549 Walker B; other site 234621012550 D-loop; other site 234621012551 H-loop/switch region; other site 234621012552 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234621012553 dimer interface [polypeptide binding]; other site 234621012554 conserved gate region; other site 234621012555 ABC-ATPase subunit interface; other site 234621012556 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 234621012557 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234621012558 ABC-ATPase subunit interface; other site 234621012559 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 234621012560 Malic enzyme, N-terminal domain; Region: malic; pfam00390 234621012561 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 234621012562 NAD(P) binding pocket [chemical binding]; other site 234621012563 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 234621012564 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 234621012565 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 234621012566 active site 234621012567 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 234621012568 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 234621012569 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 234621012570 oligomer interface [polypeptide binding]; other site 234621012571 metal binding site [ion binding]; metal-binding site 234621012572 metal binding site [ion binding]; metal-binding site 234621012573 putative Cl binding site [ion binding]; other site 234621012574 basic sphincter; other site 234621012575 hydrophobic gate; other site 234621012576 periplasmic entrance; other site 234621012577 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865 234621012578 putative hydrophobic ligand binding site [chemical binding]; other site 234621012579 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 234621012580 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 234621012581 Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403 234621012582 putative active site [active] 234621012583 putative metal binding site [ion binding]; other site 234621012584 Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403 234621012585 putative active site [active] 234621012586 putative metal binding site [ion binding]; other site 234621012587 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 234621012588 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 234621012589 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234621012590 ATP binding site [chemical binding]; other site 234621012591 Mg2+ binding site [ion binding]; other site 234621012592 G-X-G motif; other site 234621012593 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 234621012594 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 234621012595 Walker A/P-loop; other site 234621012596 ATP binding site [chemical binding]; other site 234621012597 Q-loop/lid; other site 234621012598 ABC transporter signature motif; other site 234621012599 Walker B; other site 234621012600 D-loop; other site 234621012601 H-loop/switch region; other site 234621012602 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 234621012603 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234621012604 dimer interface [polypeptide binding]; other site 234621012605 conserved gate region; other site 234621012606 putative PBP binding loops; other site 234621012607 ABC-ATPase subunit interface; other site 234621012608 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 234621012609 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234621012610 dimer interface [polypeptide binding]; other site 234621012611 conserved gate region; other site 234621012612 putative PBP binding loops; other site 234621012613 ABC-ATPase subunit interface; other site 234621012614 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 234621012615 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 234621012616 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 234621012617 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 234621012618 MgtE intracellular N domain; Region: MgtE_N; smart00924 234621012619 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 234621012620 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 234621012621 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 234621012622 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 234621012623 N-acetyl-D-glucosamine binding site [chemical binding]; other site 234621012624 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 234621012625 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 234621012626 N-acetyl-D-glucosamine binding site [chemical binding]; other site 234621012627 Domain of unknown function DUF59; Region: DUF59; cl00941 234621012628 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 234621012629 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 234621012630 sec-independent translocase; Provisional; Region: PRK03100 234621012631 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 234621012632 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 234621012633 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 234621012634 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 234621012635 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234621012636 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234621012637 DNA binding residues [nucleotide binding] 234621012638 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 234621012639 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234621012640 S-adenosylmethionine binding site [chemical binding]; other site 234621012641 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 234621012642 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 234621012643 ligand binding site; other site 234621012644 oligomer interface; other site 234621012645 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 234621012646 dimer interface [polypeptide binding]; other site 234621012647 N-terminal domain interface [polypeptide binding]; other site 234621012648 sulfate 1 binding site; other site 234621012649 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 234621012650 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 234621012651 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 234621012652 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234621012653 S-adenosylmethionine binding site [chemical binding]; other site 234621012654 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 234621012655 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 234621012656 DivIVA domain; Region: DivI1A_domain; TIGR03544 234621012657 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 234621012658 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 234621012659 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 234621012660 dihydropteroate synthase; Region: DHPS; TIGR01496 234621012661 substrate binding pocket [chemical binding]; other site 234621012662 dimer interface [polypeptide binding]; other site 234621012663 inhibitor binding site; inhibition site 234621012664 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 234621012665 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 234621012666 acyl-activating enzyme (AAE) consensus motif; other site 234621012667 putative AMP binding site [chemical binding]; other site 234621012668 putative active site [active] 234621012669 putative CoA binding site [chemical binding]; other site 234621012670 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 234621012671 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 234621012672 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 234621012673 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 234621012674 metal binding site [ion binding]; metal-binding site 234621012675 putative dimer interface [polypeptide binding]; other site 234621012676 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 234621012677 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 234621012678 putative trimer interface [polypeptide binding]; other site 234621012679 putative CoA binding site [chemical binding]; other site 234621012680 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 234621012681 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 234621012682 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 234621012683 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 234621012684 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 234621012685 Walker A/P-loop; other site 234621012686 ATP binding site [chemical binding]; other site 234621012687 Q-loop/lid; other site 234621012688 ABC transporter signature motif; other site 234621012689 Walker B; other site 234621012690 D-loop; other site 234621012691 H-loop/switch region; other site 234621012692 Domain of unknown function (DUF222); Region: DUF222; pfam02720 234621012693 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 234621012694 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 234621012695 metal ion-dependent adhesion site (MIDAS); other site 234621012696 acyl-CoA synthetase; Validated; Region: PRK07787 234621012697 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621012698 acyl-activating enzyme (AAE) consensus motif; other site 234621012699 AMP binding site [chemical binding]; other site 234621012700 active site 234621012701 CoA binding site [chemical binding]; other site 234621012702 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 234621012703 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 234621012704 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234621012705 homodimer interface [polypeptide binding]; other site 234621012706 catalytic residue [active] 234621012707 Ferredoxin [Energy production and conversion]; Region: COG1146 234621012708 4Fe-4S binding domain; Region: Fer4; pfam00037 234621012709 FO synthase; Reviewed; Region: fbiC; PRK09234 234621012710 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 234621012711 FeS/SAM binding site; other site 234621012712 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 234621012713 FeS/SAM binding site; other site 234621012714 Uncharacterized conserved protein [Function unknown]; Region: COG3402 234621012715 Predicted membrane protein [Function unknown]; Region: COG3428 234621012716 Bacterial PH domain; Region: DUF304; pfam03703 234621012717 Bacterial PH domain; Region: DUF304; pfam03703 234621012718 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 234621012719 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 234621012720 active site 234621012721 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 234621012722 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 234621012723 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 234621012724 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 234621012725 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 234621012726 G1 box; other site 234621012727 putative GEF interaction site [polypeptide binding]; other site 234621012728 GTP/Mg2+ binding site [chemical binding]; other site 234621012729 Switch I region; other site 234621012730 G2 box; other site 234621012731 G3 box; other site 234621012732 Switch II region; other site 234621012733 G4 box; other site 234621012734 G5 box; other site 234621012735 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 234621012736 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 234621012737 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 234621012738 active site 234621012739 8-oxo-dGMP binding site [chemical binding]; other site 234621012740 nudix motif; other site 234621012741 metal binding site [ion binding]; metal-binding site 234621012742 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 234621012743 aromatic arch; other site 234621012744 DCoH dimer interaction site [polypeptide binding]; other site 234621012745 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 234621012746 DCoH tetramer interaction site [polypeptide binding]; other site 234621012747 substrate binding site [chemical binding]; other site 234621012748 Transcriptional regulators [Transcription]; Region: MarR; COG1846 234621012749 MarR family; Region: MarR_2; cl17246 234621012750 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621012751 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621012752 SnoaL-like domain; Region: SnoaL_2; pfam12680 234621012753 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 234621012754 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 234621012755 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 234621012756 guanine deaminase; Provisional; Region: PRK09228 234621012757 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234621012758 active site 234621012759 CAAX protease self-immunity; Region: Abi; pfam02517 234621012760 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 234621012761 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 234621012762 siderophore binding site; other site 234621012763 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 234621012764 dimer interface [polypeptide binding]; other site 234621012765 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 234621012766 Putative esterase; Region: Esterase; pfam00756 234621012767 Putative esterase; Region: Esterase; pfam00756 234621012768 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 234621012769 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 234621012770 fumarate hydratase; Provisional; Region: PRK15389 234621012771 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 234621012772 Fumarase C-terminus; Region: Fumerase_C; pfam05683 234621012773 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 234621012774 active site 234621012775 SUMO-1 interface [polypeptide binding]; other site 234621012776 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 234621012777 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 234621012778 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 234621012779 putative hydrophobic ligand binding site [chemical binding]; other site 234621012780 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234621012781 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 234621012782 active site 234621012783 metal binding site [ion binding]; metal-binding site 234621012784 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 234621012785 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 234621012786 LDH/MDH dimer interface [polypeptide binding]; other site 234621012787 NAD(P) binding site [chemical binding]; other site 234621012788 substrate binding site [chemical binding]; other site 234621012789 PE-PPE domain; Region: PE-PPE; pfam08237 234621012790 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 234621012791 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 234621012792 active site 234621012793 catalytic site [active] 234621012794 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 234621012795 active site 234621012796 GTP-binding protein YchF; Reviewed; Region: PRK09601 234621012797 YchF GTPase; Region: YchF; cd01900 234621012798 G1 box; other site 234621012799 GTP/Mg2+ binding site [chemical binding]; other site 234621012800 Switch I region; other site 234621012801 G2 box; other site 234621012802 Switch II region; other site 234621012803 G3 box; other site 234621012804 G4 box; other site 234621012805 G5 box; other site 234621012806 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 234621012807 Interferon-induced transmembrane protein; Region: CD225; pfam04505 234621012808 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 234621012809 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 234621012810 active site 234621012811 FMN binding site [chemical binding]; other site 234621012812 substrate binding site [chemical binding]; other site 234621012813 3Fe-4S cluster binding site [ion binding]; other site 234621012814 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 234621012815 Carbon starvation protein CstA; Region: CstA; pfam02554 234621012816 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 234621012817 Protein of unknown function (DUF466); Region: DUF466; pfam04328 234621012818 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 234621012819 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 234621012820 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234621012821 Walker A/P-loop; other site 234621012822 ATP binding site [chemical binding]; other site 234621012823 Q-loop/lid; other site 234621012824 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234621012825 Walker B; other site 234621012826 D-loop; other site 234621012827 H-loop/switch region; other site 234621012828 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 234621012829 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 234621012830 active site 234621012831 metal binding site [ion binding]; metal-binding site 234621012832 DNA binding site [nucleotide binding] 234621012833 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 234621012834 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 234621012835 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 234621012836 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 234621012837 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 234621012838 generic binding surface II; other site 234621012839 generic binding surface I; other site 234621012840 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 234621012841 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 234621012842 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 234621012843 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 234621012844 putative active site [active] 234621012845 fumarate hydratase; Reviewed; Region: fumC; PRK00485 234621012846 Class II fumarases; Region: Fumarase_classII; cd01362 234621012847 active site 234621012848 tetramer interface [polypeptide binding]; other site 234621012849 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 234621012850 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 234621012851 Domain of unknown function (DUF385); Region: DUF385; cl04387 234621012852 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621012853 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621012854 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621012855 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621012856 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 234621012857 Beta-lactamase; Region: Beta-lactamase; pfam00144 234621012858 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 234621012859 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 234621012860 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 234621012861 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 234621012862 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 234621012863 putative active site [active] 234621012864 PhoH-like protein; Region: PhoH; pfam02562 234621012865 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 234621012866 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 234621012867 DNA binding residues [nucleotide binding] 234621012868 dimerization interface [polypeptide binding]; other site 234621012869 putative amidase; Provisional; Region: PRK06169 234621012870 Amidase; Region: Amidase; pfam01425 234621012871 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 234621012872 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 234621012873 dimer interface [polypeptide binding]; other site 234621012874 active site 234621012875 glycine-pyridoxal phosphate binding site [chemical binding]; other site 234621012876 folate binding site [chemical binding]; other site 234621012877 pantothenate kinase; Provisional; Region: PRK05439 234621012878 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 234621012879 ATP-binding site [chemical binding]; other site 234621012880 CoA-binding site [chemical binding]; other site 234621012881 Mg2+-binding site [ion binding]; other site 234621012882 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 234621012883 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 234621012884 catalytic residue [active] 234621012885 putative FPP diphosphate binding site; other site 234621012886 putative FPP binding hydrophobic cleft; other site 234621012887 dimer interface [polypeptide binding]; other site 234621012888 putative IPP diphosphate binding site; other site 234621012889 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 234621012890 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 234621012891 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 234621012892 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 234621012893 catalytic residues [active] 234621012894 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 234621012895 putative active cleft [active] 234621012896 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 234621012897 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 234621012898 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 234621012899 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 234621012900 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 234621012901 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 234621012902 NlpC/P60 family; Region: NLPC_P60; pfam00877 234621012903 ApbE family; Region: ApbE; pfam02424 234621012904 threonine dehydratase; Provisional; Region: PRK08198 234621012905 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 234621012906 tetramer interface [polypeptide binding]; other site 234621012907 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234621012908 catalytic residue [active] 234621012909 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 234621012910 cystathionine gamma-synthase; Provisional; Region: PRK07811 234621012911 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 234621012912 homodimer interface [polypeptide binding]; other site 234621012913 substrate-cofactor binding pocket; other site 234621012914 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234621012915 catalytic residue [active] 234621012916 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 234621012917 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 234621012918 dimer interface [polypeptide binding]; other site 234621012919 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234621012920 catalytic residue [active] 234621012921 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 234621012922 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 234621012923 active site 234621012924 catalytic triad [active] 234621012925 oxyanion hole [active] 234621012926 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 234621012927 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 234621012928 dimer interface [polypeptide binding]; other site 234621012929 active site 234621012930 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 234621012931 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 234621012932 substrate binding site [chemical binding]; other site 234621012933 oxyanion hole (OAH) forming residues; other site 234621012934 trimer interface [polypeptide binding]; other site 234621012935 Bax inhibitor 1 like; Region: BaxI_1; cl17691 234621012936 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 234621012937 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234621012938 S-adenosylmethionine binding site [chemical binding]; other site 234621012939 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 234621012940 putative FMN binding site [chemical binding]; other site 234621012941 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 234621012942 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 234621012943 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 234621012944 classical (c) SDRs; Region: SDR_c; cd05233 234621012945 NAD(P) binding site [chemical binding]; other site 234621012946 active site 234621012947 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 234621012948 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 234621012949 metal binding site [ion binding]; metal-binding site 234621012950 active site 234621012951 I-site; other site 234621012952 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 234621012953 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 234621012954 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 234621012955 metal binding site [ion binding]; metal-binding site 234621012956 active site 234621012957 I-site; other site 234621012958 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 234621012959 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 234621012960 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 234621012961 putative metal binding site [ion binding]; other site 234621012962 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 234621012963 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 234621012964 active site 234621012965 exopolyphosphatase; Region: exo_poly_only; TIGR03706 234621012966 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 234621012967 Uncharacterized conserved protein [Function unknown]; Region: COG1507 234621012968 Septum formation initiator; Region: DivIC; pfam04977 234621012969 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 234621012970 enolase; Provisional; Region: eno; PRK00077 234621012971 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 234621012972 dimer interface [polypeptide binding]; other site 234621012973 metal binding site [ion binding]; metal-binding site 234621012974 substrate binding pocket [chemical binding]; other site 234621012975 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 234621012976 N-acetyl-D-glucosamine binding site [chemical binding]; other site 234621012977 Iron permease FTR1 family; Region: FTR1; cl00475 234621012978 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 234621012979 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 234621012980 Imelysin; Region: Peptidase_M75; pfam09375 234621012981 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 234621012982 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 234621012983 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 234621012984 putative ADP-binding pocket [chemical binding]; other site 234621012985 exosortase A system-associated hydrolase 2; Region: hydr2_PEP; TIGR03101 234621012986 O-Antigen ligase; Region: Wzy_C; cl04850 234621012987 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 234621012988 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 234621012989 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 234621012990 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 234621012991 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 234621012992 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 234621012993 Glycosyl hydrolase family 14; Region: Glyco_hydro_14; cl03185 234621012994 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 234621012995 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 234621012996 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 234621012997 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 234621012998 putative active site [active] 234621012999 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 234621013000 Bacterial sugar transferase; Region: Bac_transf; pfam02397 234621013001 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 234621013002 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 234621013003 homodimer interface [polypeptide binding]; other site 234621013004 metal binding site [ion binding]; metal-binding site 234621013005 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 234621013006 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 234621013007 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 234621013008 ATP binding site [chemical binding]; other site 234621013009 putative Mg++ binding site [ion binding]; other site 234621013010 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 234621013011 nucleotide binding region [chemical binding]; other site 234621013012 ATP-binding site [chemical binding]; other site 234621013013 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 234621013014 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 234621013015 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 234621013016 Domain of unknown function (DUF1839); Region: DUF1839; pfam08893 234621013017 hypothetical protein; Validated; Region: PRK07080 234621013018 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621013019 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621013020 active site 234621013021 acyl carrier protein; Provisional; Region: PRK07081 234621013022 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 234621013023 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621013024 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621013025 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621013026 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621013027 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 234621013028 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 234621013029 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 234621013030 Substrate binding site; other site 234621013031 Mg++ binding site; other site 234621013032 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 234621013033 active site 234621013034 substrate binding site [chemical binding]; other site 234621013035 CoA binding site [chemical binding]; other site 234621013036 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 234621013037 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 234621013038 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 234621013039 active site 234621013040 argininosuccinate lyase; Provisional; Region: PRK02186 234621013041 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 234621013042 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 234621013043 transmembrane helices; other site 234621013044 TrkA-C domain; Region: TrkA_C; pfam02080 234621013045 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 234621013046 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 234621013047 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 234621013048 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 234621013049 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 234621013050 Domain of unknown function (DUF222); Region: DUF222; pfam02720 234621013051 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 234621013052 active site 234621013053 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 234621013054 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 234621013055 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 234621013056 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 234621013057 putative active site [active] 234621013058 putative dimer interface [polypeptide binding]; other site 234621013059 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 234621013060 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 234621013061 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 234621013062 amino acid transporter; Region: 2A0306; TIGR00909 234621013063 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 234621013064 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 234621013065 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 234621013066 catalytic residue [active] 234621013067 hypothetical protein; Validated; Region: PRK07121 234621013068 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 234621013069 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 234621013070 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 234621013071 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 234621013072 5S rRNA interface [nucleotide binding]; other site 234621013073 CTC domain interface [polypeptide binding]; other site 234621013074 L16 interface [polypeptide binding]; other site 234621013075 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 234621013076 putative active site [active] 234621013077 catalytic residue [active] 234621013078 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 234621013079 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 234621013080 acyl-activating enzyme (AAE) consensus motif; other site 234621013081 active site 234621013082 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 234621013083 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 234621013084 G1 box; other site 234621013085 putative GEF interaction site [polypeptide binding]; other site 234621013086 GTP/Mg2+ binding site [chemical binding]; other site 234621013087 Switch I region; other site 234621013088 G2 box; other site 234621013089 G3 box; other site 234621013090 Switch II region; other site 234621013091 G4 box; other site 234621013092 G5 box; other site 234621013093 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 234621013094 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 234621013095 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 234621013096 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 234621013097 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 234621013098 SnoaL-like domain; Region: SnoaL_4; pfam13577 234621013099 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621013100 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 234621013101 DNA-binding interface [nucleotide binding]; DNA binding site 234621013102 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 234621013103 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 234621013104 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 234621013105 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234621013106 Walker A/P-loop; other site 234621013107 ATP binding site [chemical binding]; other site 234621013108 Q-loop/lid; other site 234621013109 ABC transporter signature motif; other site 234621013110 Walker B; other site 234621013111 D-loop; other site 234621013112 H-loop/switch region; other site 234621013113 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 234621013114 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 234621013115 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234621013116 Walker A/P-loop; other site 234621013117 ATP binding site [chemical binding]; other site 234621013118 Q-loop/lid; other site 234621013119 ABC transporter signature motif; other site 234621013120 Walker B; other site 234621013121 D-loop; other site 234621013122 H-loop/switch region; other site 234621013123 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 234621013124 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 234621013125 intersubunit interface [polypeptide binding]; other site 234621013126 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621013127 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621013128 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621013129 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621013130 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 234621013131 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 234621013132 intersubunit interface [polypeptide binding]; other site 234621013133 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 234621013134 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 234621013135 intersubunit interface [polypeptide binding]; other site 234621013136 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 234621013137 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 234621013138 Walker A/P-loop; other site 234621013139 ATP binding site [chemical binding]; other site 234621013140 Q-loop/lid; other site 234621013141 ABC transporter signature motif; other site 234621013142 Walker B; other site 234621013143 D-loop; other site 234621013144 H-loop/switch region; other site 234621013145 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 234621013146 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 234621013147 ABC-ATPase subunit interface; other site 234621013148 dimer interface [polypeptide binding]; other site 234621013149 putative PBP binding regions; other site 234621013150 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 234621013151 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 234621013152 ABC-ATPase subunit interface; other site 234621013153 dimer interface [polypeptide binding]; other site 234621013154 putative PBP binding regions; other site 234621013155 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 234621013156 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 234621013157 FAD binding pocket [chemical binding]; other site 234621013158 FAD binding motif [chemical binding]; other site 234621013159 phosphate binding motif [ion binding]; other site 234621013160 NAD binding pocket [chemical binding]; other site 234621013161 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 234621013162 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234621013163 Walker A/P-loop; other site 234621013164 ATP binding site [chemical binding]; other site 234621013165 ABC transporter; Region: ABC_tran; pfam00005 234621013166 Q-loop/lid; other site 234621013167 ABC transporter signature motif; other site 234621013168 Walker B; other site 234621013169 D-loop; other site 234621013170 H-loop/switch region; other site 234621013171 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 234621013172 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 234621013173 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234621013174 Walker A/P-loop; other site 234621013175 ATP binding site [chemical binding]; other site 234621013176 Q-loop/lid; other site 234621013177 ABC transporter signature motif; other site 234621013178 Walker B; other site 234621013179 D-loop; other site 234621013180 H-loop/switch region; other site 234621013181 Cupin domain; Region: Cupin_2; cl17218 234621013182 Helix-turn-helix domain; Region: HTH_18; pfam12833 234621013183 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 234621013184 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 234621013185 active site 234621013186 Domain of unknown function (DUF222); Region: DUF222; pfam02720 234621013187 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 234621013188 active site 234621013189 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621013190 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 234621013191 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 234621013192 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 234621013193 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 234621013194 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 234621013195 ABC-2 type transporter; Region: ABC2_membrane; cl17235 234621013196 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 234621013197 ABC-2 type transporter; Region: ABC2_membrane; cl17235 234621013198 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 234621013199 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234621013200 Walker A/P-loop; other site 234621013201 ATP binding site [chemical binding]; other site 234621013202 Q-loop/lid; other site 234621013203 ABC transporter signature motif; other site 234621013204 Walker B; other site 234621013205 D-loop; other site 234621013206 H-loop/switch region; other site 234621013207 Predicted transcriptional regulator [Transcription]; Region: COG2378 234621013208 WYL domain; Region: WYL; pfam13280 234621013209 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 234621013210 DNA-binding site [nucleotide binding]; DNA binding site 234621013211 RNA-binding motif; other site 234621013212 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 234621013213 metal-binding site [ion binding] 234621013214 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 234621013215 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 234621013216 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 234621013217 metal-binding site [ion binding] 234621013218 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 234621013219 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 234621013220 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234621013221 S-adenosylmethionine binding site [chemical binding]; other site 234621013222 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 234621013223 Domain of unknown function (DUF348); Region: DUF348; pfam03990 234621013224 Domain of unknown function (DUF348); Region: DUF348; pfam03990 234621013225 Domain of unknown function (DUF348); Region: DUF348; pfam03990 234621013226 G5 domain; Region: G5; pfam07501 234621013227 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 234621013228 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 234621013229 Domain of unknown function (DUF348); Region: DUF348; pfam03990 234621013230 Domain of unknown function (DUF348); Region: DUF348; pfam03990 234621013231 G5 domain; Region: G5; pfam07501 234621013232 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 234621013233 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 234621013234 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 234621013235 substrate binding pocket [chemical binding]; other site 234621013236 membrane-bound complex binding site; other site 234621013237 hinge residues; other site 234621013238 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 234621013239 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234621013240 dimer interface [polypeptide binding]; other site 234621013241 conserved gate region; other site 234621013242 putative PBP binding loops; other site 234621013243 ABC-ATPase subunit interface; other site 234621013244 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 234621013245 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 234621013246 Walker A/P-loop; other site 234621013247 ATP binding site [chemical binding]; other site 234621013248 Q-loop/lid; other site 234621013249 ABC transporter signature motif; other site 234621013250 Walker B; other site 234621013251 D-loop; other site 234621013252 H-loop/switch region; other site 234621013253 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 234621013254 active site 234621013255 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 234621013256 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 234621013257 active site 234621013258 HIGH motif; other site 234621013259 KMSKS motif; other site 234621013260 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 234621013261 tRNA binding surface [nucleotide binding]; other site 234621013262 anticodon binding site; other site 234621013263 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 234621013264 Predicted methyltransferases [General function prediction only]; Region: COG0313 234621013265 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 234621013266 putative SAM binding site [chemical binding]; other site 234621013267 putative homodimer interface [polypeptide binding]; other site 234621013268 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 234621013269 BCCT family transporter; Region: BCCT; pfam02028 234621013270 Predicted membrane protein [Function unknown]; Region: COG2259 234621013271 Predicted transcriptional regulators [Transcription]; Region: COG1725 234621013272 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 234621013273 DNA-binding site [nucleotide binding]; DNA binding site 234621013274 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 234621013275 NADH(P)-binding; Region: NAD_binding_10; pfam13460 234621013276 NAD(P) binding site [chemical binding]; other site 234621013277 putative active site [active] 234621013278 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 234621013279 ArsC family; Region: ArsC; pfam03960 234621013280 catalytic residues [active] 234621013281 arginine deiminase; Provisional; Region: PRK01388 234621013282 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 234621013283 heme-binding site [chemical binding]; other site 234621013284 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 234621013285 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 234621013286 DNA binding residues [nucleotide binding] 234621013287 dimer interface [polypeptide binding]; other site 234621013288 [2Fe-2S] cluster binding site [ion binding]; other site 234621013289 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 234621013290 short chain dehydrogenase; Provisional; Region: PRK07832 234621013291 classical (c) SDRs; Region: SDR_c; cd05233 234621013292 NAD(P) binding site [chemical binding]; other site 234621013293 active site 234621013294 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234621013295 sequence-specific DNA binding site [nucleotide binding]; other site 234621013296 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 234621013297 salt bridge; other site 234621013298 Domain of unknown function (DUF955); Region: DUF955; cl01076 234621013299 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 234621013300 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 234621013301 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 234621013302 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 234621013303 dimer interface [polypeptide binding]; other site 234621013304 putative functional site; other site 234621013305 putative MPT binding site; other site 234621013306 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 234621013307 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 234621013308 active site 234621013309 tetramer interface; other site 234621013310 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 234621013311 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 234621013312 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 234621013313 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 234621013314 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 234621013315 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 234621013316 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 234621013317 MPT binding site; other site 234621013318 trimer interface [polypeptide binding]; other site 234621013319 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 234621013320 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 234621013321 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 234621013322 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 234621013323 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 234621013324 dimerization interface [polypeptide binding]; other site 234621013325 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234621013326 dimer interface [polypeptide binding]; other site 234621013327 phosphorylation site [posttranslational modification] 234621013328 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234621013329 ATP binding site [chemical binding]; other site 234621013330 Mg2+ binding site [ion binding]; other site 234621013331 G-X-G motif; other site 234621013332 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 234621013333 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234621013334 active site 234621013335 phosphorylation site [posttranslational modification] 234621013336 intermolecular recognition site; other site 234621013337 dimerization interface [polypeptide binding]; other site 234621013338 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 234621013339 DNA binding site [nucleotide binding] 234621013340 Predicted membrane protein [Function unknown]; Region: COG2860 234621013341 UPF0126 domain; Region: UPF0126; pfam03458 234621013342 UPF0126 domain; Region: UPF0126; pfam03458 234621013343 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 234621013344 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 234621013345 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 234621013346 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 234621013347 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 234621013348 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 234621013349 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 234621013350 30S ribosomal protein S18; Provisional; Region: PRK13401 234621013351 Predicted permeases [General function prediction only]; Region: COG0679 234621013352 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 234621013353 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 234621013354 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 234621013355 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 234621013356 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 234621013357 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 234621013358 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 234621013359 tetrameric interface [polypeptide binding]; other site 234621013360 NAD binding site [chemical binding]; other site 234621013361 catalytic residues [active] 234621013362 substrate binding site [chemical binding]; other site 234621013363 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 234621013364 Ligand Binding Site [chemical binding]; other site 234621013365 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 234621013366 Ligand Binding Site [chemical binding]; other site 234621013367 Amino acid permease; Region: AA_permease_2; pfam13520 234621013368 tetracycline repressor protein TetR; Provisional; Region: PRK13756 234621013369 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 234621013370 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 234621013371 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 234621013372 active site 234621013373 catalytic triad [active] 234621013374 dimer interface [polypeptide binding]; other site 234621013375 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 234621013376 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 234621013377 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 234621013378 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 234621013379 metal ion-dependent adhesion site (MIDAS); other site 234621013380 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 234621013381 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 234621013382 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 234621013383 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234621013384 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 234621013385 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 234621013386 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 234621013387 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 234621013388 purine monophosphate binding site [chemical binding]; other site 234621013389 dimer interface [polypeptide binding]; other site 234621013390 putative catalytic residues [active] 234621013391 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 234621013392 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 234621013393 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 234621013394 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 234621013395 active site 234621013396 substrate binding site [chemical binding]; other site 234621013397 cosubstrate binding site; other site 234621013398 catalytic site [active] 234621013399 Uncharacterized conserved protein [Function unknown]; Region: COG1739 234621013400 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 234621013401 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 234621013402 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 234621013403 CoA binding domain; Region: CoA_binding; smart00881 234621013404 CoA-ligase; Region: Ligase_CoA; pfam00549 234621013405 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 234621013406 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 234621013407 CoA-ligase; Region: Ligase_CoA; pfam00549 234621013408 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 234621013409 Peptidase family M23; Region: Peptidase_M23; pfam01551 234621013410 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 234621013411 Part of AAA domain; Region: AAA_19; pfam13245 234621013412 Family description; Region: UvrD_C_2; pfam13538 234621013413 hypothetical protein; Provisional; Region: PRK07857 234621013414 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 234621013415 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 234621013416 tetramerization interface [polypeptide binding]; other site 234621013417 NAD(P) binding site [chemical binding]; other site 234621013418 catalytic residues [active] 234621013419 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 234621013420 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 234621013421 active site 234621013422 dimer interface [polypeptide binding]; other site 234621013423 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 234621013424 dimer interface [polypeptide binding]; other site 234621013425 active site 234621013426 ApbE family; Region: ApbE; pfam02424 234621013427 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234621013428 sequence-specific DNA binding site [nucleotide binding]; other site 234621013429 salt bridge; other site 234621013430 ABC-2 type transporter; Region: ABC2_membrane; cl17235 234621013431 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 234621013432 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 234621013433 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234621013434 Walker A/P-loop; other site 234621013435 ATP binding site [chemical binding]; other site 234621013436 Q-loop/lid; other site 234621013437 ABC transporter signature motif; other site 234621013438 Walker B; other site 234621013439 D-loop; other site 234621013440 H-loop/switch region; other site 234621013441 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 234621013442 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 234621013443 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4315 234621013444 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 234621013445 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 234621013446 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 234621013447 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 234621013448 short chain dehydrogenase; Provisional; Region: PRK08251 234621013449 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621013450 NAD(P) binding site [chemical binding]; other site 234621013451 active site 234621013452 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 234621013453 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 234621013454 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 234621013455 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 234621013456 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 234621013457 substrate binding pocket [chemical binding]; other site 234621013458 catalytic triad [active] 234621013459 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 234621013460 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 234621013461 substrate binding pocket [chemical binding]; other site 234621013462 catalytic triad [active] 234621013463 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234621013464 non-specific DNA binding site [nucleotide binding]; other site 234621013465 salt bridge; other site 234621013466 sequence-specific DNA binding site [nucleotide binding]; other site 234621013467 Cupin domain; Region: Cupin_2; pfam07883 234621013468 class II aldolase/adducin domain protein; Provisional; Region: PRK07090 234621013469 intersubunit interface [polypeptide binding]; other site 234621013470 active site 234621013471 Zn2+ binding site [ion binding]; other site 234621013472 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 234621013473 inhibitor site; inhibition site 234621013474 dihydrodipicolinate synthase; Region: dapA; TIGR00674 234621013475 active site 234621013476 dimer interface [polypeptide binding]; other site 234621013477 catalytic residue [active] 234621013478 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 234621013479 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 234621013480 NADP binding site [chemical binding]; other site 234621013481 DEAD-like helicases superfamily; Region: DEXDc; smart00487 234621013482 Helicase_C-like; Region: Helicase_C_4; pfam13871 234621013483 Domain of unknown function (DUF385); Region: DUF385; cl04387 234621013484 Domain of unknown function (DUF427); Region: DUF427; pfam04248 234621013485 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 234621013486 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 234621013487 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621013488 putative substrate translocation pore; other site 234621013489 Transcriptional regulator [Transcription]; Region: LysR; COG0583 234621013490 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 234621013491 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 234621013492 putative dimerization interface [polypeptide binding]; other site 234621013493 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 234621013494 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 234621013495 putative DNA binding site [nucleotide binding]; other site 234621013496 catalytic residue [active] 234621013497 putative H2TH interface [polypeptide binding]; other site 234621013498 putative catalytic residues [active] 234621013499 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 234621013500 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 234621013501 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 234621013502 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 234621013503 metal binding site [ion binding]; metal-binding site 234621013504 active site 234621013505 I-site; other site 234621013506 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 234621013507 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 234621013508 metal binding site [ion binding]; metal-binding site 234621013509 active site 234621013510 I-site; other site 234621013511 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 234621013512 active site 234621013513 SAM binding site [chemical binding]; other site 234621013514 homodimer interface [polypeptide binding]; other site 234621013515 thymidylate synthase; Reviewed; Region: thyA; PRK01827 234621013516 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 234621013517 dimerization interface [polypeptide binding]; other site 234621013518 active site 234621013519 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 234621013520 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 234621013521 folate binding site [chemical binding]; other site 234621013522 NADP+ binding site [chemical binding]; other site 234621013523 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 234621013524 GAF domain; Region: GAF; pfam01590 234621013525 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 234621013526 Histidine kinase; Region: HisKA_3; pfam07730 234621013527 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 234621013528 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 234621013529 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234621013530 active site 234621013531 phosphorylation site [posttranslational modification] 234621013532 intermolecular recognition site; other site 234621013533 dimerization interface [polypeptide binding]; other site 234621013534 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 234621013535 DNA binding residues [nucleotide binding] 234621013536 dimerization interface [polypeptide binding]; other site 234621013537 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 234621013538 Ligand Binding Site [chemical binding]; other site 234621013539 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 234621013540 Ligand Binding Site [chemical binding]; other site 234621013541 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 234621013542 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 234621013543 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 234621013544 Ligand Binding Site [chemical binding]; other site 234621013545 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 234621013546 Ligand Binding Site [chemical binding]; other site 234621013547 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 234621013548 Peptidase family M23; Region: Peptidase_M23; pfam01551 234621013549 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 234621013550 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 234621013551 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 234621013552 motif II; other site 234621013553 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 234621013554 D-xylulose kinase; Region: XylB; TIGR01312 234621013555 nucleotide binding site [chemical binding]; other site 234621013556 Transcription factor WhiB; Region: Whib; pfam02467 234621013557 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 234621013558 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 234621013559 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 234621013560 nucleotide binding site [chemical binding]; other site 234621013561 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621013562 metabolite-proton symporter; Region: 2A0106; TIGR00883 234621013563 putative substrate translocation pore; other site 234621013564 enoyl-CoA hydratase; Provisional; Region: PRK07509 234621013565 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 234621013566 substrate binding site [chemical binding]; other site 234621013567 oxyanion hole (OAH) forming residues; other site 234621013568 trimer interface [polypeptide binding]; other site 234621013569 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 234621013570 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 234621013571 SnoaL-like domain; Region: SnoaL_2; pfam12680 234621013572 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621013573 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 234621013574 acyl-activating enzyme (AAE) consensus motif; other site 234621013575 AMP binding site [chemical binding]; other site 234621013576 active site 234621013577 CoA binding site [chemical binding]; other site 234621013578 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 234621013579 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 234621013580 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 234621013581 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 234621013582 TM-ABC transporter signature motif; other site 234621013583 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 234621013584 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 234621013585 TM-ABC transporter signature motif; other site 234621013586 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 234621013587 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 234621013588 Walker A/P-loop; other site 234621013589 ATP binding site [chemical binding]; other site 234621013590 Q-loop/lid; other site 234621013591 ABC transporter signature motif; other site 234621013592 Walker B; other site 234621013593 D-loop; other site 234621013594 H-loop/switch region; other site 234621013595 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 234621013596 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 234621013597 Walker A/P-loop; other site 234621013598 ATP binding site [chemical binding]; other site 234621013599 Q-loop/lid; other site 234621013600 ABC transporter signature motif; other site 234621013601 Walker B; other site 234621013602 D-loop; other site 234621013603 H-loop/switch region; other site 234621013604 SnoaL-like domain; Region: SnoaL_4; pfam13577 234621013605 short chain dehydrogenase; Validated; Region: PRK08264 234621013606 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621013607 NAD(P) binding site [chemical binding]; other site 234621013608 active site 234621013609 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 234621013610 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 234621013611 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621013612 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 234621013613 acyl-activating enzyme (AAE) consensus motif; other site 234621013614 acyl-activating enzyme (AAE) consensus motif; other site 234621013615 putative AMP binding site [chemical binding]; other site 234621013616 putative active site [active] 234621013617 putative CoA binding site [chemical binding]; other site 234621013618 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 234621013619 active site 234621013620 metal binding site [ion binding]; metal-binding site 234621013621 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 234621013622 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 234621013623 acetyl-CoA acetyltransferase; Provisional; Region: PRK06289 234621013624 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 234621013625 active site 234621013626 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 234621013627 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 234621013628 dimer interface [polypeptide binding]; other site 234621013629 active site 234621013630 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621013631 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 234621013632 NAD(P) binding site [chemical binding]; other site 234621013633 active site 234621013634 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 234621013635 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 234621013636 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 234621013637 active site 234621013638 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 234621013639 catalytic triad [active] 234621013640 dimer interface [polypeptide binding]; other site 234621013641 Predicted transcriptional regulators [Transcription]; Region: COG1733 234621013642 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 234621013643 Predicted transcriptional regulators [Transcription]; Region: COG1733 234621013644 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 234621013645 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 234621013646 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 234621013647 active site 234621013648 non-prolyl cis peptide bond; other site 234621013649 Phage capsid family; Region: Phage_capsid; pfam05065 234621013650 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 234621013651 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 234621013652 active site 234621013653 Helix-turn-helix domain; Region: HTH_17; cl17695 234621013654 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 234621013655 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 234621013656 active site 234621013657 catalytic residues [active] 234621013658 DNA binding site [nucleotide binding] 234621013659 Int/Topo IB signature motif; other site 234621013660 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 234621013661 Uncharacterized conserved protein [Function unknown]; Region: COG1262 234621013662 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 234621013663 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 234621013664 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 234621013665 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621013666 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621013667 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 234621013668 Sulfatase; Region: Sulfatase; pfam00884 234621013669 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 234621013670 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 234621013671 dimerization interface [polypeptide binding]; other site 234621013672 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 234621013673 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234621013674 dimer interface [polypeptide binding]; other site 234621013675 phosphorylation site [posttranslational modification] 234621013676 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234621013677 ATP binding site [chemical binding]; other site 234621013678 Mg2+ binding site [ion binding]; other site 234621013679 G-X-G motif; other site 234621013680 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 234621013681 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234621013682 active site 234621013683 phosphorylation site [posttranslational modification] 234621013684 intermolecular recognition site; other site 234621013685 dimerization interface [polypeptide binding]; other site 234621013686 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 234621013687 DNA binding site [nucleotide binding] 234621013688 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 234621013689 NlpC/P60 family; Region: NLPC_P60; pfam00877 234621013690 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 234621013691 Beta-lactamase; Region: Beta-lactamase; pfam00144 234621013692 Erythromycin esterase; Region: Erythro_esteras; pfam05139 234621013693 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 234621013694 DNA binding residues [nucleotide binding] 234621013695 Second Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt2; cd04773 234621013696 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 234621013697 DNA binding residues [nucleotide binding] 234621013698 putative dimer interface [polypeptide binding]; other site 234621013699 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 234621013700 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 234621013701 nucleotide binding site [chemical binding]; other site 234621013702 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 234621013703 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 234621013704 active site 234621013705 DNA binding site [nucleotide binding] 234621013706 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 234621013707 DNA binding site [nucleotide binding] 234621013708 Transcription factor WhiB; Region: Whib; pfam02467 234621013709 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 234621013710 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 234621013711 substrate binding pocket [chemical binding]; other site 234621013712 membrane-bound complex binding site; other site 234621013713 hinge residues; other site 234621013714 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 234621013715 metal ion-dependent adhesion site (MIDAS); other site 234621013716 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 234621013717 hydrophobic ligand binding site; other site 234621013718 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 234621013719 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 234621013720 Na binding site [ion binding]; other site 234621013721 Protein of unknown function, DUF485; Region: DUF485; pfam04341 234621013722 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 234621013723 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 234621013724 Na binding site [ion binding]; other site 234621013725 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 234621013726 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234621013727 active site 234621013728 phosphorylation site [posttranslational modification] 234621013729 intermolecular recognition site; other site 234621013730 dimerization interface [polypeptide binding]; other site 234621013731 LytTr DNA-binding domain; Region: LytTR; smart00850 234621013732 Histidine kinase; Region: His_kinase; pfam06580 234621013733 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234621013734 ATP binding site [chemical binding]; other site 234621013735 Mg2+ binding site [ion binding]; other site 234621013736 G-X-G motif; other site 234621013737 Protein of unknown function (DUF419); Region: DUF419; cl15265 234621013738 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 234621013739 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 234621013740 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 234621013741 metal binding site [ion binding]; metal-binding site 234621013742 active site 234621013743 I-site; other site 234621013744 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 234621013745 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 234621013746 Soluble P-type ATPase [General function prediction only]; Region: COG4087 234621013747 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 234621013748 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 234621013749 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 234621013750 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 234621013751 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 234621013752 substrate binding site [chemical binding]; other site 234621013753 oxyanion hole (OAH) forming residues; other site 234621013754 trimer interface [polypeptide binding]; other site 234621013755 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 234621013756 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 234621013757 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 234621013758 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 234621013759 putative active site [active] 234621013760 catalytic site [active] 234621013761 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 234621013762 putative active site [active] 234621013763 catalytic site [active] 234621013764 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 234621013765 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234621013766 ATP binding site [chemical binding]; other site 234621013767 Mg2+ binding site [ion binding]; other site 234621013768 G-X-G motif; other site 234621013769 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 234621013770 Protein of unknown function (DUF742); Region: DUF742; pfam05331 234621013771 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 234621013772 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 234621013773 G1 box; other site 234621013774 GTP/Mg2+ binding site [chemical binding]; other site 234621013775 G2 box; other site 234621013776 Switch I region; other site 234621013777 G3 box; other site 234621013778 Switch II region; other site 234621013779 G4 box; other site 234621013780 G5 box; other site 234621013781 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 234621013782 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 234621013783 Predicted kinase [General function prediction only]; Region: COG0645 234621013784 AAA domain; Region: AAA_17; pfam13207 234621013785 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 234621013786 Coenzyme A binding pocket [chemical binding]; other site 234621013787 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 234621013788 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234621013789 non-specific DNA binding site [nucleotide binding]; other site 234621013790 salt bridge; other site 234621013791 sequence-specific DNA binding site [nucleotide binding]; other site 234621013792 Cupin domain; Region: Cupin_2; pfam07883 234621013793 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 234621013794 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 234621013795 Transcriptional regulators [Transcription]; Region: MarR; COG1846 234621013796 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 234621013797 putative DNA binding site [nucleotide binding]; other site 234621013798 putative Zn2+ binding site [ion binding]; other site 234621013799 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 234621013800 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 234621013801 D-pathway; other site 234621013802 Putative ubiquinol binding site [chemical binding]; other site 234621013803 Low-spin heme (heme b) binding site [chemical binding]; other site 234621013804 Putative water exit pathway; other site 234621013805 Binuclear center (heme o3/CuB) [ion binding]; other site 234621013806 K-pathway; other site 234621013807 Putative proton exit pathway; other site 234621013808 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 234621013809 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 234621013810 putative active site [active] 234621013811 putative FMN binding site [chemical binding]; other site 234621013812 putative substrate binding site [chemical binding]; other site 234621013813 putative catalytic residue [active] 234621013814 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 234621013815 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 234621013816 active site 234621013817 catalytic tetrad [active] 234621013818 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234621013819 S-adenosylmethionine binding site [chemical binding]; other site 234621013820 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 234621013821 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 234621013822 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234621013823 D-loop; other site 234621013824 H-loop/switch region; other site 234621013825 ABC transporter; Region: ABC_tran_2; pfam12848 234621013826 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 234621013827 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 234621013828 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 234621013829 active site 234621013830 catalytic tetrad [active] 234621013831 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621013832 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621013833 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234621013834 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 234621013835 active site 234621013836 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 234621013837 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234621013838 salt bridge; other site 234621013839 non-specific DNA binding site [nucleotide binding]; other site 234621013840 sequence-specific DNA binding site [nucleotide binding]; other site 234621013841 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 234621013842 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234621013843 Walker A/P-loop; other site 234621013844 ATP binding site [chemical binding]; other site 234621013845 Q-loop/lid; other site 234621013846 ABC transporter signature motif; other site 234621013847 Walker B; other site 234621013848 D-loop; other site 234621013849 H-loop/switch region; other site 234621013850 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 234621013851 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 234621013852 Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777 234621013853 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 234621013854 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621013855 H+ Antiporter protein; Region: 2A0121; TIGR00900 234621013856 putative substrate translocation pore; other site 234621013857 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 234621013858 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 234621013859 acyl-activating enzyme (AAE) consensus motif; other site 234621013860 putative AMP binding site [chemical binding]; other site 234621013861 putative active site [active] 234621013862 putative CoA binding site [chemical binding]; other site 234621013863 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 234621013864 classical (c) SDRs; Region: SDR_c; cd05233 234621013865 NAD(P) binding site [chemical binding]; other site 234621013866 active site 234621013867 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 234621013868 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621013869 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621013870 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621013871 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621013872 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621013873 Major Facilitator Superfamily; Region: MFS_1; pfam07690 234621013874 putative substrate translocation pore; other site 234621013875 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234621013876 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 234621013877 putative dimer interface [polypeptide binding]; other site 234621013878 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 234621013879 DNA photolyase; Region: DNA_photolyase; pfam00875 234621013880 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621013881 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621013882 Protein of unknown function (DUF952); Region: DUF952; cl01393 234621013883 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621013884 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621013885 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 234621013886 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234621013887 active site 234621013888 phosphorylation site [posttranslational modification] 234621013889 intermolecular recognition site; other site 234621013890 dimerization interface [polypeptide binding]; other site 234621013891 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 234621013892 DNA binding site [nucleotide binding] 234621013893 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 234621013894 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234621013895 phosphorylation site [posttranslational modification] 234621013896 dimer interface [polypeptide binding]; other site 234621013897 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234621013898 ATP binding site [chemical binding]; other site 234621013899 Mg2+ binding site [ion binding]; other site 234621013900 G-X-G motif; other site 234621013901 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 234621013902 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 234621013903 Sulfate transporter family; Region: Sulfate_transp; pfam00916 234621013904 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 234621013905 active site clefts [active] 234621013906 zinc binding site [ion binding]; other site 234621013907 dimer interface [polypeptide binding]; other site 234621013908 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 234621013909 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 234621013910 active site 234621013911 catalytic tetrad [active] 234621013912 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 234621013913 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 234621013914 short chain dehydrogenase; Provisional; Region: PRK06701 234621013915 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 234621013916 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 234621013917 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 234621013918 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 234621013919 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 234621013920 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 234621013921 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 234621013922 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 234621013923 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 234621013924 E3 interaction surface; other site 234621013925 lipoyl attachment site [posttranslational modification]; other site 234621013926 e3 binding domain; Region: E3_binding; pfam02817 234621013927 e3 binding domain; Region: E3_binding; pfam02817 234621013928 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 234621013929 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 234621013930 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 234621013931 alpha subunit interface [polypeptide binding]; other site 234621013932 TPP binding site [chemical binding]; other site 234621013933 heterodimer interface [polypeptide binding]; other site 234621013934 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 234621013935 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 234621013936 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 234621013937 tetramer interface [polypeptide binding]; other site 234621013938 TPP-binding site [chemical binding]; other site 234621013939 heterodimer interface [polypeptide binding]; other site 234621013940 phosphorylation loop region [posttranslational modification] 234621013941 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 234621013942 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234621013943 active site 234621013944 phosphorylation site [posttranslational modification] 234621013945 intermolecular recognition site; other site 234621013946 dimerization interface [polypeptide binding]; other site 234621013947 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 234621013948 DNA binding site [nucleotide binding] 234621013949 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 234621013950 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 234621013951 dimer interface [polypeptide binding]; other site 234621013952 phosphorylation site [posttranslational modification] 234621013953 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234621013954 ATP binding site [chemical binding]; other site 234621013955 Mg2+ binding site [ion binding]; other site 234621013956 G-X-G motif; other site 234621013957 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 234621013958 glycerol kinase; Provisional; Region: glpK; PRK00047 234621013959 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 234621013960 N- and C-terminal domain interface [polypeptide binding]; other site 234621013961 active site 234621013962 MgATP binding site [chemical binding]; other site 234621013963 catalytic site [active] 234621013964 metal binding site [ion binding]; metal-binding site 234621013965 putative homotetramer interface [polypeptide binding]; other site 234621013966 glycerol binding site [chemical binding]; other site 234621013967 homodimer interface [polypeptide binding]; other site 234621013968 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 234621013969 amphipathic channel; other site 234621013970 Asn-Pro-Ala signature motifs; other site 234621013971 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 234621013972 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234621013973 DNA binding residues [nucleotide binding] 234621013974 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 234621013975 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621013976 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621013977 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 234621013978 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234621013979 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 234621013980 Walker A/P-loop; other site 234621013981 ATP binding site [chemical binding]; other site 234621013982 Q-loop/lid; other site 234621013983 ABC transporter signature motif; other site 234621013984 Walker B; other site 234621013985 D-loop; other site 234621013986 H-loop/switch region; other site 234621013987 ABC-2 type transporter; Region: ABC2_membrane; cl17235 234621013988 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 234621013989 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 234621013990 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 234621013991 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 234621013992 dimer interface [polypeptide binding]; other site 234621013993 active site 234621013994 citrylCoA binding site [chemical binding]; other site 234621013995 NADH binding [chemical binding]; other site 234621013996 cationic pore residues; other site 234621013997 oxalacetate/citrate binding site [chemical binding]; other site 234621013998 coenzyme A binding site [chemical binding]; other site 234621013999 catalytic triad [active] 234621014000 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 234621014001 active site 234621014002 catalytic residues [active] 234621014003 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621014004 putative substrate translocation pore; other site 234621014005 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 234621014006 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 234621014007 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 234621014008 citrate synthase 2; Provisional; Region: PRK12350 234621014009 Citrate synthase; Region: Citrate_synt; pfam00285 234621014010 oxalacetate binding site [chemical binding]; other site 234621014011 citrylCoA binding site [chemical binding]; other site 234621014012 coenzyme A binding site [chemical binding]; other site 234621014013 catalytic triad [active] 234621014014 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 234621014015 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 234621014016 catalytic residue [active] 234621014017 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 234621014018 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 234621014019 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 234621014020 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621014021 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 234621014022 H+ Antiporter protein; Region: 2A0121; TIGR00900 234621014023 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621014024 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 234621014025 MarR family; Region: MarR; pfam01047 234621014026 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 234621014027 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 234621014028 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 234621014029 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 234621014030 siderophore binding site; other site 234621014031 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 234621014032 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 234621014033 active site 234621014034 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 234621014035 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 234621014036 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 234621014037 H+ Antiporter protein; Region: 2A0121; TIGR00900 234621014038 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 234621014039 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 234621014040 DNA-binding site [nucleotide binding]; DNA binding site 234621014041 RNA-binding motif; other site 234621014042 hypothetical protein; Provisional; Region: PRK11770 234621014043 Domain of unknown function (DUF307); Region: DUF307; pfam03733 234621014044 Domain of unknown function (DUF307); Region: DUF307; pfam03733 234621014045 Uncharacterized conserved protein [Function unknown]; Region: COG3391 234621014046 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 234621014047 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 234621014048 WYL domain; Region: WYL; pfam13280 234621014049 Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1; Region: Peptidase_C12; cl08306 234621014050 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621014051 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621014052 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 234621014053 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 234621014054 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 234621014055 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 234621014056 NAD(P) binding site [chemical binding]; other site 234621014057 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 234621014058 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 234621014059 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 234621014060 putative Mg++ binding site [ion binding]; other site 234621014061 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 234621014062 nucleotide binding region [chemical binding]; other site 234621014063 ATP-binding site [chemical binding]; other site 234621014064 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234621014065 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234621014066 Protein of unknown function (DUF3239); Region: DUF3239; pfam11580 234621014067 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 234621014068 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 234621014069 Major Facilitator Superfamily; Region: MFS_1; pfam07690 234621014070 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621014071 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621014072 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 234621014073 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 234621014074 active site 234621014075 non-prolyl cis peptide bond; other site 234621014076 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 234621014077 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234621014078 dimer interface [polypeptide binding]; other site 234621014079 conserved gate region; other site 234621014080 putative PBP binding loops; other site 234621014081 ABC-ATPase subunit interface; other site 234621014082 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 234621014083 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 234621014084 Walker A/P-loop; other site 234621014085 ATP binding site [chemical binding]; other site 234621014086 Q-loop/lid; other site 234621014087 ABC transporter signature motif; other site 234621014088 Walker B; other site 234621014089 D-loop; other site 234621014090 H-loop/switch region; other site 234621014091 NMT1/THI5 like; Region: NMT1; pfam09084 234621014092 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 234621014093 membrane-bound complex binding site; other site 234621014094 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 234621014095 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234621014096 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234621014097 DNA binding residues [nucleotide binding] 234621014098 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237 234621014099 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 234621014100 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621014101 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621014102 active site 234621014103 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621014104 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621014105 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621014106 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 234621014107 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 234621014108 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 234621014109 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 234621014110 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 234621014111 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 234621014112 FMN-binding pocket [chemical binding]; other site 234621014113 flavin binding motif; other site 234621014114 phosphate binding motif [ion binding]; other site 234621014115 beta-alpha-beta structure motif; other site 234621014116 NAD binding pocket [chemical binding]; other site 234621014117 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 234621014118 catalytic loop [active] 234621014119 iron binding site [ion binding]; other site 234621014120 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 234621014121 putative hydrophobic ligand binding site [chemical binding]; other site 234621014122 protein interface [polypeptide binding]; other site 234621014123 gate; other site 234621014124 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 234621014125 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 234621014126 NAD(P) binding site [chemical binding]; other site 234621014127 catalytic residues [active] 234621014128 short chain dehydrogenase; Provisional; Region: PRK05872 234621014129 classical (c) SDRs; Region: SDR_c; cd05233 234621014130 NAD(P) binding site [chemical binding]; other site 234621014131 active site 234621014132 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 234621014133 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 234621014134 acyl-activating enzyme (AAE) consensus motif; other site 234621014135 putative AMP binding site [chemical binding]; other site 234621014136 putative active site [active] 234621014137 putative CoA binding site [chemical binding]; other site 234621014138 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234621014139 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 234621014140 Walker A/P-loop; other site 234621014141 ATP binding site [chemical binding]; other site 234621014142 Q-loop/lid; other site 234621014143 ABC transporter signature motif; other site 234621014144 Walker B; other site 234621014145 D-loop; other site 234621014146 H-loop/switch region; other site 234621014147 TOBE domain; Region: TOBE; cl01440 234621014148 sulfate transport protein; Provisional; Region: cysT; CHL00187 234621014149 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 234621014150 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 234621014151 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 234621014152 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 234621014153 DNA binding residues [nucleotide binding] 234621014154 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 234621014155 Uncharacterized conserved protein [Function unknown]; Region: COG2128 234621014156 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 234621014157 aminotransferase; Validated; Region: PRK07777 234621014158 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 234621014159 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234621014160 homodimer interface [polypeptide binding]; other site 234621014161 catalytic residue [active] 234621014162 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 234621014163 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 234621014164 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 234621014165 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 234621014166 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 234621014167 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 234621014168 putative DNA binding site [nucleotide binding]; other site 234621014169 putative Zn2+ binding site [ion binding]; other site 234621014170 AsnC family; Region: AsnC_trans_reg; pfam01037 234621014171 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 234621014172 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 234621014173 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 234621014174 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 234621014175 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 234621014176 DNA binding residues [nucleotide binding] 234621014177 dimer interface [polypeptide binding]; other site 234621014178 Herpesvirus UL43 protein; Region: Herpes_UL43; cl17419 234621014179 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 234621014180 acyl-CoA synthetase; Validated; Region: PRK06188 234621014181 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621014182 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 234621014183 putative active site [active] 234621014184 putative CoA binding site [chemical binding]; other site 234621014185 putative AMP binding site [chemical binding]; other site 234621014186 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 234621014187 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 234621014188 substrate binding site [chemical binding]; other site 234621014189 oxyanion hole (OAH) forming residues; other site 234621014190 trimer interface [polypeptide binding]; other site 234621014191 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 234621014192 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 234621014193 classical (c) SDRs; Region: SDR_c; cd05233 234621014194 NAD(P) binding site [chemical binding]; other site 234621014195 active site 234621014196 Transcriptional regulator [Transcription]; Region: LysR; COG0583 234621014197 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 234621014198 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 234621014199 dimerization interface [polypeptide binding]; other site 234621014200 substrate binding pocket [chemical binding]; other site 234621014201 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621014202 metabolite-proton symporter; Region: 2A0106; TIGR00883 234621014203 putative substrate translocation pore; other site 234621014204 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 234621014205 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 234621014206 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 234621014207 NAD(P) binding site [chemical binding]; other site 234621014208 shikimate binding site; other site 234621014209 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 234621014210 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 234621014211 active site 234621014212 FMN binding site [chemical binding]; other site 234621014213 substrate binding site [chemical binding]; other site 234621014214 putative catalytic residue [active] 234621014215 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 234621014216 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 234621014217 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 234621014218 active site 234621014219 catalytic tetrad [active] 234621014220 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 234621014221 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 234621014222 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 234621014223 hypothetical protein; Provisional; Region: PRK12839 234621014224 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 234621014225 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 234621014226 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 234621014227 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 234621014228 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 234621014229 intersubunit interface [polypeptide binding]; other site 234621014230 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 234621014231 SnoaL-like domain; Region: SnoaL_2; pfam12680 234621014232 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 234621014233 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 234621014234 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 234621014235 Glutamate binding site [chemical binding]; other site 234621014236 NAD binding site [chemical binding]; other site 234621014237 catalytic residues [active] 234621014238 Proline dehydrogenase; Region: Pro_dh; cl03282 234621014239 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 234621014240 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 234621014241 active site 234621014242 non-prolyl cis peptide bond; other site 234621014243 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 234621014244 CGNR zinc finger; Region: zf-CGNR; pfam11706 234621014245 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 234621014246 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 234621014247 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 234621014248 Walker A/P-loop; other site 234621014249 ATP binding site [chemical binding]; other site 234621014250 Q-loop/lid; other site 234621014251 ABC transporter signature motif; other site 234621014252 Walker B; other site 234621014253 D-loop; other site 234621014254 H-loop/switch region; other site 234621014255 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 234621014256 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 234621014257 Histidine kinase; Region: HisKA_3; pfam07730 234621014258 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 234621014259 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234621014260 active site 234621014261 phosphorylation site [posttranslational modification] 234621014262 intermolecular recognition site; other site 234621014263 dimerization interface [polypeptide binding]; other site 234621014264 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 234621014265 DNA binding residues [nucleotide binding] 234621014266 dimerization interface [polypeptide binding]; other site 234621014267 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 234621014268 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234621014269 sequence-specific DNA binding site [nucleotide binding]; other site 234621014270 salt bridge; other site 234621014271 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 234621014272 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 234621014273 THF binding site; other site 234621014274 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 234621014275 substrate binding site [chemical binding]; other site 234621014276 THF binding site; other site 234621014277 zinc-binding site [ion binding]; other site 234621014278 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 234621014279 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 234621014280 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621014281 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621014282 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 234621014283 MarR family; Region: MarR_2; cl17246 234621014284 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 234621014285 fumarylacetoacetase; Region: PLN02856 234621014286 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 234621014287 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 234621014288 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 234621014289 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 234621014290 Clp amino terminal domain; Region: Clp_N; pfam02861 234621014291 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234621014292 Walker A motif; other site 234621014293 ATP binding site [chemical binding]; other site 234621014294 Walker B motif; other site 234621014295 arginine finger; other site 234621014296 UvrB/uvrC motif; Region: UVR; pfam02151 234621014297 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 234621014298 Walker A motif; other site 234621014299 ATP binding site [chemical binding]; other site 234621014300 Walker B motif; other site 234621014301 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 234621014302 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 234621014303 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621014304 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 234621014305 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 234621014306 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 234621014307 CGNR zinc finger; Region: zf-CGNR; pfam11706 234621014308 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 234621014309 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 234621014310 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 234621014311 active site 234621014312 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 234621014313 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 234621014314 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 234621014315 dimer interface [polypeptide binding]; other site 234621014316 PYR/PP interface [polypeptide binding]; other site 234621014317 TPP binding site [chemical binding]; other site 234621014318 substrate binding site [chemical binding]; other site 234621014319 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 234621014320 TPP-binding site [chemical binding]; other site 234621014321 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 234621014322 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 234621014323 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 234621014324 DNA binding residues [nucleotide binding] 234621014325 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 234621014326 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 234621014327 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 234621014328 DNA binding residues [nucleotide binding] 234621014329 dimerization interface [polypeptide binding]; other site 234621014330 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 234621014331 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 234621014332 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 234621014333 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 234621014334 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 234621014335 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 234621014336 Condensation domain; Region: Condensation; pfam00668 234621014337 Condensation domain; Region: Condensation; pfam00668 234621014338 Condensation domain; Region: Condensation; pfam00668 234621014339 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 234621014340 MarR family; Region: MarR; pfam01047 234621014341 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 234621014342 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 234621014343 Prostaglandin dehydrogenases; Region: PGDH; cd05288 234621014344 NAD(P) binding site [chemical binding]; other site 234621014345 substrate binding site [chemical binding]; other site 234621014346 dimer interface [polypeptide binding]; other site 234621014347 short chain dehydrogenase; Provisional; Region: PRK06197 234621014348 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 234621014349 putative NAD(P) binding site [chemical binding]; other site 234621014350 active site 234621014351 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 234621014352 Transcriptional regulator [Transcription]; Region: LysR; COG0583 234621014353 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 234621014354 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 234621014355 putative substrate binding pocket [chemical binding]; other site 234621014356 putative dimerization interface [polypeptide binding]; other site 234621014357 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 234621014358 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621014359 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621014360 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 234621014361 Predicted ATPase [General function prediction only]; Region: COG3903 234621014362 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234621014363 TPR motif; other site 234621014364 binding surface 234621014365 Tetratricopeptide repeat; Region: TPR_12; pfam13424 234621014366 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 234621014367 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 234621014368 DNA binding residues [nucleotide binding] 234621014369 dimerization interface [polypeptide binding]; other site 234621014370 Transcriptional regulators [Transcription]; Region: GntR; COG1802 234621014371 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 234621014372 DNA-binding site [nucleotide binding]; DNA binding site 234621014373 FCD domain; Region: FCD; pfam07729 234621014374 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 234621014375 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 234621014376 Na binding site [ion binding]; other site 234621014377 putative substrate binding site [chemical binding]; other site 234621014378 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 234621014379 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 234621014380 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621014381 putative substrate translocation pore; other site 234621014382 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 234621014383 dimerization interface [polypeptide binding]; other site 234621014384 putative DNA binding site [nucleotide binding]; other site 234621014385 putative Zn2+ binding site [ion binding]; other site 234621014386 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 234621014387 mce related protein; Region: MCE; pfam02470 234621014388 Methyltransferase domain; Region: Methyltransf_11; pfam08241 234621014389 S-adenosylmethionine binding site [chemical binding]; other site 234621014390 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 234621014391 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 234621014392 active site 234621014393 catalytic site [active] 234621014394 tetramer interface [polypeptide binding]; other site 234621014395 allantoicase; Provisional; Region: PRK13257 234621014396 Allantoicase repeat; Region: Allantoicase; pfam03561 234621014397 Allantoicase repeat; Region: Allantoicase; pfam03561 234621014398 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 234621014399 Predicted acyl esterases [General function prediction only]; Region: COG2936 234621014400 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234621014401 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 234621014402 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 234621014403 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 234621014404 probable active site [active] 234621014405 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 234621014406 putative active site; other site 234621014407 putative metal binding residues [ion binding]; other site 234621014408 signature motif; other site 234621014409 putative triphosphate binding site [ion binding]; other site 234621014410 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 234621014411 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 234621014412 Ligand Binding Site [chemical binding]; other site 234621014413 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 234621014414 Ligand Binding Site [chemical binding]; other site 234621014415 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 234621014416 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 234621014417 classical (c) SDRs; Region: SDR_c; cd05233 234621014418 NAD(P) binding site [chemical binding]; other site 234621014419 active site 234621014420 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621014421 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621014422 cell division protein FtsW; Region: ftsW; TIGR02614 234621014423 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621014424 putative substrate translocation pore; other site 234621014425 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 234621014426 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 234621014427 active site 234621014428 non-prolyl cis peptide bond; other site 234621014429 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 234621014430 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 234621014431 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 234621014432 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 234621014433 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621014434 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621014435 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 234621014436 Transcriptional regulators [Transcription]; Region: MarR; COG1846 234621014437 MarR family; Region: MarR_2; pfam12802 234621014438 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621014439 putative substrate translocation pore; other site 234621014440 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621014441 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 234621014442 Protease prsW family; Region: PrsW-protease; pfam13367 234621014443 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 234621014444 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621014445 GXWXG protein; Region: GXWXG; pfam14231 234621014446 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 234621014447 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 234621014448 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 234621014449 catalytic Zn binding site [ion binding]; other site 234621014450 NAD binding site [chemical binding]; other site 234621014451 structural Zn binding site [ion binding]; other site 234621014452 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 234621014453 Protein of unknown function (DUF419); Region: DUF419; pfam04237 234621014454 Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078 234621014455 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621014456 Major Facilitator Superfamily; Region: MFS_1; pfam07690 234621014457 Transcriptional regulator [Transcription]; Region: LysR; COG0583 234621014458 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 234621014459 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 234621014460 putative dimerization interface [polypeptide binding]; other site 234621014461 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 234621014462 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 234621014463 homodimer interface [polypeptide binding]; other site 234621014464 putative substrate binding pocket [chemical binding]; other site 234621014465 diiron center [ion binding]; other site 234621014466 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 234621014467 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 234621014468 FMN binding site [chemical binding]; other site 234621014469 active site 234621014470 catalytic residues [active] 234621014471 substrate binding site [chemical binding]; other site 234621014472 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 234621014473 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 234621014474 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 234621014475 PhoU domain; Region: PhoU; pfam01895 234621014476 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621014477 NADH(P)-binding; Region: NAD_binding_10; pfam13460 234621014478 NAD(P) binding site [chemical binding]; other site 234621014479 active site 234621014480 UreD urease accessory protein; Region: UreD; cl00530 234621014481 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 234621014482 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 234621014483 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 234621014484 UreF; Region: UreF; pfam01730 234621014485 urease subunit alpha; Reviewed; Region: ureC; PRK13206 234621014486 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 234621014487 subunit interactions [polypeptide binding]; other site 234621014488 active site 234621014489 flap region; other site 234621014490 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 234621014491 gamma-beta subunit interface [polypeptide binding]; other site 234621014492 alpha-beta subunit interface [polypeptide binding]; other site 234621014493 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 234621014494 alpha-gamma subunit interface [polypeptide binding]; other site 234621014495 beta-gamma subunit interface [polypeptide binding]; other site 234621014496 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 234621014497 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 234621014498 Walker A/P-loop; other site 234621014499 ATP binding site [chemical binding]; other site 234621014500 Q-loop/lid; other site 234621014501 ABC transporter signature motif; other site 234621014502 Walker B; other site 234621014503 D-loop; other site 234621014504 H-loop/switch region; other site 234621014505 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 234621014506 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234621014507 dimer interface [polypeptide binding]; other site 234621014508 conserved gate region; other site 234621014509 putative PBP binding loops; other site 234621014510 ABC-ATPase subunit interface; other site 234621014511 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 234621014512 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234621014513 dimer interface [polypeptide binding]; other site 234621014514 conserved gate region; other site 234621014515 putative PBP binding loops; other site 234621014516 ABC-ATPase subunit interface; other site 234621014517 PBP superfamily domain; Region: PBP_like_2; cl17296 234621014518 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 234621014519 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 234621014520 Coenzyme A binding pocket [chemical binding]; other site 234621014521 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 234621014522 Coenzyme A binding pocket [chemical binding]; other site 234621014523 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 234621014524 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 234621014525 DNA binding site [nucleotide binding] 234621014526 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 234621014527 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 234621014528 catalytic residues [active] 234621014529 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 234621014530 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 234621014531 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 234621014532 active site residue [active] 234621014533 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 234621014534 active site residue [active] 234621014535 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 234621014536 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 234621014537 heme-binding site [chemical binding]; other site 234621014538 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 234621014539 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 234621014540 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234621014541 Walker A/P-loop; other site 234621014542 ATP binding site [chemical binding]; other site 234621014543 Q-loop/lid; other site 234621014544 ABC transporter signature motif; other site 234621014545 Walker B; other site 234621014546 D-loop; other site 234621014547 H-loop/switch region; other site 234621014548 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 234621014549 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 234621014550 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 234621014551 Walker A/P-loop; other site 234621014552 ATP binding site [chemical binding]; other site 234621014553 Q-loop/lid; other site 234621014554 ABC transporter signature motif; other site 234621014555 Walker B; other site 234621014556 D-loop; other site 234621014557 H-loop/switch region; other site 234621014558 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 234621014559 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 234621014560 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 234621014561 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 234621014562 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 234621014563 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 234621014564 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234621014565 catalytic residue [active] 234621014566 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 234621014567 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 234621014568 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 234621014569 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 234621014570 MOSC domain; Region: MOSC; pfam03473 234621014571 L-asparaginase II; Region: Asparaginase_II; pfam06089 234621014572 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 234621014573 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 234621014574 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 234621014575 dimerization interface [polypeptide binding]; other site 234621014576 putative ATP binding site [chemical binding]; other site 234621014577 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 234621014578 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 234621014579 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 234621014580 amidophosphoribosyltransferase; Provisional; Region: PRK07847 234621014581 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 234621014582 active site 234621014583 tetramer interface [polypeptide binding]; other site 234621014584 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 234621014585 active site 234621014586 CAAX protease self-immunity; Region: Abi; pfam02517 234621014587 Predicted membrane protein [Function unknown]; Region: COG4425 234621014588 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 234621014589 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 234621014590 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 234621014591 dimerization interface [polypeptide binding]; other site 234621014592 ATP binding site [chemical binding]; other site 234621014593 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 234621014594 dimerization interface [polypeptide binding]; other site 234621014595 ATP binding site [chemical binding]; other site 234621014596 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 234621014597 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 234621014598 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 234621014599 active site 234621014600 metal binding site [ion binding]; metal-binding site 234621014601 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 234621014602 active site 234621014603 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 234621014604 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 234621014605 trimer interface [polypeptide binding]; other site 234621014606 active site 234621014607 substrate binding site [chemical binding]; other site 234621014608 CoA binding site [chemical binding]; other site 234621014609 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621014610 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621014611 active site 234621014612 Putative esterase; Region: Esterase; pfam00756 234621014613 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 234621014614 active site 234621014615 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 234621014616 classical (c) SDRs; Region: SDR_c; cd05233 234621014617 NAD(P) binding site [chemical binding]; other site 234621014618 active site 234621014619 SnoaL-like domain; Region: SnoaL_2; pfam12680 234621014620 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 234621014621 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 234621014622 PGAP1-like protein; Region: PGAP1; pfam07819 234621014623 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 234621014624 Prostaglandin dehydrogenases; Region: PGDH; cd05288 234621014625 NAD(P) binding site [chemical binding]; other site 234621014626 substrate binding site [chemical binding]; other site 234621014627 dimer interface [polypeptide binding]; other site 234621014628 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 234621014629 CoA-transferase family III; Region: CoA_transf_3; pfam02515 234621014630 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621014631 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621014632 active site 234621014633 Transcriptional regulators [Transcription]; Region: PurR; COG1609 234621014634 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 234621014635 DNA binding site [nucleotide binding] 234621014636 domain linker motif; other site 234621014637 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_7; cd06285 234621014638 putative dimerization interface [polypeptide binding]; other site 234621014639 putative ligand binding site [chemical binding]; other site 234621014640 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 234621014641 putative hydrophobic ligand binding site [chemical binding]; other site 234621014642 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 234621014643 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 234621014644 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 234621014645 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 234621014646 substrate binding pocket [chemical binding]; other site 234621014647 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234621014648 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621014649 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621014650 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 234621014651 Patatin-like phospholipase; Region: Patatin; pfam01734 234621014652 nucleophile elbow; other site 234621014653 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 234621014654 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 234621014655 short chain dehydrogenase; Provisional; Region: PRK07825 234621014656 classical (c) SDRs; Region: SDR_c; cd05233 234621014657 NAD(P) binding site [chemical binding]; other site 234621014658 active site 234621014659 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 234621014660 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 234621014661 Coenzyme A binding pocket [chemical binding]; other site 234621014662 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 234621014663 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234621014664 non-specific DNA binding site [nucleotide binding]; other site 234621014665 salt bridge; other site 234621014666 sequence-specific DNA binding site [nucleotide binding]; other site 234621014667 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 234621014668 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 234621014669 Walker A/P-loop; other site 234621014670 ATP binding site [chemical binding]; other site 234621014671 Q-loop/lid; other site 234621014672 ABC transporter signature motif; other site 234621014673 Walker B; other site 234621014674 D-loop; other site 234621014675 H-loop/switch region; other site 234621014676 taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729 234621014677 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 234621014678 substrate binding pocket [chemical binding]; other site 234621014679 membrane-bound complex binding site; other site 234621014680 hinge residues; other site 234621014681 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 234621014682 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234621014683 dimer interface [polypeptide binding]; other site 234621014684 conserved gate region; other site 234621014685 putative PBP binding loops; other site 234621014686 ABC-ATPase subunit interface; other site 234621014687 Methyltransferase domain; Region: Methyltransf_31; pfam13847 234621014688 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234621014689 S-adenosylmethionine binding site [chemical binding]; other site 234621014690 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 234621014691 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 234621014692 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 234621014693 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 234621014694 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 234621014695 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 234621014696 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 234621014697 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 234621014698 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 234621014699 putative metal binding site [ion binding]; other site 234621014700 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 234621014701 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 234621014702 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 234621014703 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 234621014704 metal binding site [ion binding]; metal-binding site 234621014705 active site 234621014706 I-site; other site 234621014707 Domain of unknown function (DUF222); Region: DUF222; pfam02720 234621014708 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 234621014709 active site 234621014710 Transcriptional regulators [Transcription]; Region: MarR; COG1846 234621014711 MarR family; Region: MarR; pfam01047 234621014712 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 234621014713 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 234621014714 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 234621014715 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 234621014716 Hemerythrin-like domain; Region: Hr-like; cd12108 234621014717 Fe binding site [ion binding]; other site 234621014718 Interferon-induced transmembrane protein; Region: CD225; pfam04505 234621014719 Secretory lipase; Region: LIP; pfam03583 234621014720 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 234621014721 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 234621014722 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621014723 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 234621014724 NAD(P) binding site [chemical binding]; other site 234621014725 active site 234621014726 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 234621014727 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621014728 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621014729 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 234621014730 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621014731 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621014732 PspC domain; Region: PspC; pfam04024 234621014733 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 234621014734 PGAP1-like protein; Region: PGAP1; pfam07819 234621014735 PPOX class probable F420-dependent enzyme, MSMEG_5819 family; Region: PPOX_MSMEG_5819; TIGR04023 234621014736 Predicted transcriptional regulators [Transcription]; Region: COG1733 234621014737 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 234621014738 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 234621014739 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 234621014740 active site 234621014741 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 234621014742 catalytic triad [active] 234621014743 dimer interface [polypeptide binding]; other site 234621014744 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 234621014745 CoA-transferase family III; Region: CoA_transf_3; pfam02515 234621014746 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621014747 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621014748 active site 234621014749 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 234621014750 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621014751 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 234621014752 acyl-activating enzyme (AAE) consensus motif; other site 234621014753 acyl-activating enzyme (AAE) consensus motif; other site 234621014754 putative AMP binding site [chemical binding]; other site 234621014755 putative active site [active] 234621014756 putative CoA binding site [chemical binding]; other site 234621014757 enoyl-CoA hydratase; Provisional; Region: PRK06688 234621014758 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 234621014759 substrate binding site [chemical binding]; other site 234621014760 oxyanion hole (OAH) forming residues; other site 234621014761 trimer interface [polypeptide binding]; other site 234621014762 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621014763 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621014764 active site 234621014765 D-galactonate transporter; Region: 2A0114; TIGR00893 234621014766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621014767 putative substrate translocation pore; other site 234621014768 lipid-transfer protein; Provisional; Region: PRK08256 234621014769 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 234621014770 active site 234621014771 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 234621014772 active site 234621014773 catalytic site [active] 234621014774 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 234621014775 active site 2 [active] 234621014776 active site 1 [active] 234621014777 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 234621014778 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621014779 NAD(P) binding site [chemical binding]; other site 234621014780 active site 234621014781 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 234621014782 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621014783 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 234621014784 acyl-activating enzyme (AAE) consensus motif; other site 234621014785 acyl-activating enzyme (AAE) consensus motif; other site 234621014786 putative AMP binding site [chemical binding]; other site 234621014787 putative active site [active] 234621014788 putative CoA binding site [chemical binding]; other site 234621014789 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621014790 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621014791 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621014792 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621014793 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 234621014794 putative FMN binding site [chemical binding]; other site 234621014795 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 234621014796 putative PBP binding loops; other site 234621014797 dimer interface [polypeptide binding]; other site 234621014798 ABC-ATPase subunit interface; other site 234621014799 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 234621014800 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 234621014801 Walker A/P-loop; other site 234621014802 ATP binding site [chemical binding]; other site 234621014803 Q-loop/lid; other site 234621014804 ABC transporter signature motif; other site 234621014805 Walker B; other site 234621014806 D-loop; other site 234621014807 H-loop/switch region; other site 234621014808 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234621014809 ABC-ATPase subunit interface; other site 234621014810 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 234621014811 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 234621014812 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 234621014813 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234621014814 S-adenosylmethionine binding site [chemical binding]; other site 234621014815 Catalytic domain of Streptomyces antibioticus phosphatidylinositol-specific phospholipase C1-like proteins; Region: PI-PLCc_SaPLC1_like; cd08589 234621014816 putative active site [active] 234621014817 catalytic site [active] 234621014818 putative metal binding site [ion binding]; other site 234621014819 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 234621014820 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621014821 acyl-activating enzyme (AAE) consensus motif; other site 234621014822 AMP binding site [chemical binding]; other site 234621014823 active site 234621014824 CoA binding site [chemical binding]; other site 234621014825 acyl-CoA thioesterase II; Region: tesB; TIGR00189 234621014826 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 234621014827 active site 234621014828 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 234621014829 catalytic triad [active] 234621014830 dimer interface [polypeptide binding]; other site 234621014831 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621014832 D-galactonate transporter; Region: 2A0114; TIGR00893 234621014833 putative substrate translocation pore; other site 234621014834 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621014835 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 234621014836 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 234621014837 dimer interface [polypeptide binding]; other site 234621014838 active site 234621014839 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 234621014840 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621014841 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 234621014842 putative active site [active] 234621014843 putative CoA binding site [chemical binding]; other site 234621014844 putative AMP binding site [chemical binding]; other site 234621014845 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 234621014846 active site 234621014847 catalytic site [active] 234621014848 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 234621014849 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621014850 NAD(P) binding site [chemical binding]; other site 234621014851 active site 234621014852 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 234621014853 CoA-transferase family III; Region: CoA_transf_3; pfam02515 234621014854 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 234621014855 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621014856 NAD(P) binding site [chemical binding]; other site 234621014857 active site 234621014858 lipid-transfer protein; Provisional; Region: PRK08256 234621014859 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 234621014860 active site 234621014861 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 234621014862 active site 2 [active] 234621014863 active site 1 [active] 234621014864 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621014865 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621014866 active site 234621014867 acetyl-CoA acetyltransferase; Provisional; Region: PRK06504 234621014868 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 234621014869 dimer interface [polypeptide binding]; other site 234621014870 active site 234621014871 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 234621014872 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621014873 acyl-activating enzyme (AAE) consensus motif; other site 234621014874 AMP binding site [chemical binding]; other site 234621014875 active site 234621014876 CoA binding site [chemical binding]; other site 234621014877 Transcriptional regulators [Transcription]; Region: GntR; COG1802 234621014878 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 234621014879 DNA-binding site [nucleotide binding]; DNA binding site 234621014880 FCD domain; Region: FCD; pfam07729 234621014881 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 234621014882 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 234621014883 substrate binding site [chemical binding]; other site 234621014884 oxyanion hole (OAH) forming residues; other site 234621014885 trimer interface [polypeptide binding]; other site 234621014886 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 234621014887 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621014888 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621014889 active site 234621014890 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621014891 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621014892 active site 234621014893 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621014894 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621014895 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621014896 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621014897 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621014898 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621014899 active site 234621014900 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 234621014901 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 234621014902 NAD binding site [chemical binding]; other site 234621014903 catalytic residues [active] 234621014904 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 234621014905 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 234621014906 active site 234621014907 iron coordination sites [ion binding]; other site 234621014908 substrate binding pocket [chemical binding]; other site 234621014909 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621014910 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 234621014911 Cytochrome P450; Region: p450; cl12078 234621014912 Secretory lipase; Region: LIP; pfam03583 234621014913 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 234621014914 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 234621014915 Catalytic site [active] 234621014916 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 234621014917 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 234621014918 Catalytic site [active] 234621014919 alternate signal-mediated exported protein, RER_14450 family; Region: exp_by_SipW_III; TIGR04089 234621014920 alternate signal-mediated exported protein, RER_14450 family; Region: exp_by_SipW_III; TIGR04089 234621014921 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 234621014922 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 234621014923 active site 234621014924 EamA-like transporter family; Region: EamA; pfam00892 234621014925 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621014926 WHG domain; Region: WHG; pfam13305 234621014927 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 234621014928 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 234621014929 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 234621014930 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 234621014931 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621014932 metabolite-proton symporter; Region: 2A0106; TIGR00883 234621014933 putative substrate translocation pore; other site 234621014934 hypothetical protein; Validated; Region: PRK07121 234621014935 Predicted oxidoreductase [General function prediction only]; Region: COG3573 234621014936 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 234621014937 classical (c) SDRs; Region: SDR_c; cd05233 234621014938 NAD(P) binding site [chemical binding]; other site 234621014939 active site 234621014940 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 234621014941 classical (c) SDRs; Region: SDR_c; cd05233 234621014942 NAD(P) binding site [chemical binding]; other site 234621014943 active site 234621014944 SnoaL-like domain; Region: SnoaL_4; pfam13577 234621014945 Transcriptional regulator [Transcription]; Region: IclR; COG1414 234621014946 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 234621014947 Pirin-related protein [General function prediction only]; Region: COG1741 234621014948 Pirin; Region: Pirin; pfam02678 234621014949 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 234621014950 Pirin-related protein [General function prediction only]; Region: COG1741 234621014951 Pirin; Region: Pirin; pfam02678 234621014952 Pirin; Region: Pirin; pfam02678 234621014953 Pirin-related protein [General function prediction only]; Region: COG1741 234621014954 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 234621014955 active site 1 [active] 234621014956 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 234621014957 CoenzymeA binding site [chemical binding]; other site 234621014958 subunit interaction site [polypeptide binding]; other site 234621014959 PHB binding site; other site 234621014960 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 234621014961 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 234621014962 active site 234621014963 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 234621014964 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234621014965 Walker A/P-loop; other site 234621014966 ATP binding site [chemical binding]; other site 234621014967 Q-loop/lid; other site 234621014968 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 234621014969 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234621014970 Walker A/P-loop; other site 234621014971 ATP binding site [chemical binding]; other site 234621014972 Q-loop/lid; other site 234621014973 ABC transporter signature motif; other site 234621014974 Walker B; other site 234621014975 D-loop; other site 234621014976 H-loop/switch region; other site 234621014977 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 234621014978 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234621014979 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 234621014980 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 234621014981 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 234621014982 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 234621014983 active site 234621014984 Zn binding site [ion binding]; other site 234621014985 hypothetical protein; Provisional; Region: PRK02237 234621014986 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 234621014987 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 234621014988 Walker A/P-loop; other site 234621014989 ATP binding site [chemical binding]; other site 234621014990 Q-loop/lid; other site 234621014991 ABC transporter signature motif; other site 234621014992 Walker B; other site 234621014993 D-loop; other site 234621014994 H-loop/switch region; other site 234621014995 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 234621014996 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 234621014997 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 234621014998 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234621014999 dimer interface [polypeptide binding]; other site 234621015000 conserved gate region; other site 234621015001 putative PBP binding loops; other site 234621015002 ABC-ATPase subunit interface; other site 234621015003 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 234621015004 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234621015005 dimer interface [polypeptide binding]; other site 234621015006 conserved gate region; other site 234621015007 putative PBP binding loops; other site 234621015008 ABC-ATPase subunit interface; other site 234621015009 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 234621015010 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 234621015011 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 234621015012 Ferredoxin [Energy production and conversion]; Region: COG1146 234621015013 4Fe-4S binding domain; Region: Fer4; pfam00037 234621015014 ferredoxin-NADP+ reductase; Region: PLN02852 234621015015 Dodecin; Region: Dodecin; pfam07311 234621015016 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 234621015017 Beta-lactamase; Region: Beta-lactamase; pfam00144 234621015018 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 234621015019 nucleotide binding site [chemical binding]; other site 234621015020 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 234621015021 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 234621015022 active site 234621015023 DNA binding site [nucleotide binding] 234621015024 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 234621015025 DNA binding site [nucleotide binding] 234621015026 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 234621015027 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 234621015028 oligomer interface [polypeptide binding]; other site 234621015029 metal binding site [ion binding]; metal-binding site 234621015030 metal binding site [ion binding]; metal-binding site 234621015031 putative Cl binding site [ion binding]; other site 234621015032 basic sphincter; other site 234621015033 hydrophobic gate; other site 234621015034 periplasmic entrance; other site 234621015035 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621015036 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621015037 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621015038 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 234621015039 NAD(P) binding site [chemical binding]; other site 234621015040 active site 234621015041 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 234621015042 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 234621015043 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 234621015044 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 234621015045 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 234621015046 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 234621015047 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 234621015048 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234621015049 dimer interface [polypeptide binding]; other site 234621015050 conserved gate region; other site 234621015051 putative PBP binding loops; other site 234621015052 ABC-ATPase subunit interface; other site 234621015053 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 234621015054 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234621015055 putative PBP binding loops; other site 234621015056 dimer interface [polypeptide binding]; other site 234621015057 ABC-ATPase subunit interface; other site 234621015058 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 234621015059 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 234621015060 Walker A/P-loop; other site 234621015061 ATP binding site [chemical binding]; other site 234621015062 Q-loop/lid; other site 234621015063 ABC transporter signature motif; other site 234621015064 Walker B; other site 234621015065 D-loop; other site 234621015066 H-loop/switch region; other site 234621015067 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 234621015068 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 234621015069 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 234621015070 Walker A/P-loop; other site 234621015071 ATP binding site [chemical binding]; other site 234621015072 Q-loop/lid; other site 234621015073 ABC transporter signature motif; other site 234621015074 Walker B; other site 234621015075 D-loop; other site 234621015076 H-loop/switch region; other site 234621015077 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 234621015078 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 234621015079 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 234621015080 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234621015081 Beta-lactamase; Region: Beta-lactamase; pfam00144 234621015082 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 234621015083 glutamate carboxypeptidase; Reviewed; Region: PRK06133 234621015084 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 234621015085 metal binding site [ion binding]; metal-binding site 234621015086 dimer interface [polypeptide binding]; other site 234621015087 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 234621015088 Coenzyme A binding pocket [chemical binding]; other site 234621015089 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 234621015090 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 234621015091 active site 234621015092 octamer interface [polypeptide binding]; other site 234621015093 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 234621015094 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 234621015095 active site 234621015096 catalytic site [active] 234621015097 substrate binding site [chemical binding]; other site 234621015098 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 234621015099 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 234621015100 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 234621015101 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 234621015102 DXD motif; other site 234621015103 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621015104 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 234621015105 NAD(P) binding site [chemical binding]; other site 234621015106 active site 234621015107 Uncharacterized conserved protein [Function unknown]; Region: COG5361 234621015108 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 234621015109 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 234621015110 Domain of unknown function (DUF389); Region: DUF389; pfam04087 234621015111 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 234621015112 Amidase; Region: Amidase; pfam01425 234621015113 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 234621015114 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 234621015115 DNA binding residues [nucleotide binding] 234621015116 dimerization interface [polypeptide binding]; other site 234621015117 acyl-CoA synthetase; Validated; Region: PRK08162 234621015118 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 234621015119 acyl-activating enzyme (AAE) consensus motif; other site 234621015120 putative active site [active] 234621015121 AMP binding site [chemical binding]; other site 234621015122 putative CoA binding site [chemical binding]; other site 234621015123 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 234621015124 Cytochrome P450; Region: p450; cl12078 234621015125 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621015126 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621015127 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621015128 Helix-turn-helix domain; Region: HTH_18; pfam12833 234621015129 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621015130 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 234621015131 FAD binding site [chemical binding]; other site 234621015132 homotetramer interface [polypeptide binding]; other site 234621015133 substrate binding pocket [chemical binding]; other site 234621015134 catalytic base [active] 234621015135 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 234621015136 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 234621015137 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 234621015138 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 234621015139 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 234621015140 RNA binding surface [nucleotide binding]; other site 234621015141 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 234621015142 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 234621015143 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 234621015144 putative active site [active] 234621015145 putative metal binding site [ion binding]; other site 234621015146 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621015147 Ion channel; Region: Ion_trans_2; pfam07885 234621015148 diacylglycerol kinase; Reviewed; Region: PRK11914 234621015149 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 234621015150 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 234621015151 FAD binding domain; Region: FAD_binding_4; pfam01565 234621015152 Protein of unknown function (DUF664); Region: DUF664; pfam04978 234621015153 DinB superfamily; Region: DinB_2; pfam12867 234621015154 heat shock protein 90; Provisional; Region: PRK05218 234621015155 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234621015156 ATP binding site [chemical binding]; other site 234621015157 Mg2+ binding site [ion binding]; other site 234621015158 G-X-G motif; other site 234621015159 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 234621015160 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 234621015161 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 234621015162 active site 234621015163 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 234621015164 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621015165 active site 234621015166 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 234621015167 putative active site [active] 234621015168 putative catalytic site [active] 234621015169 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621015170 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 234621015171 Transcriptional regulators [Transcription]; Region: MarR; COG1846 234621015172 MarR family; Region: MarR; pfam01047 234621015173 EVE domain; Region: EVE; cl00728 234621015174 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621015175 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621015176 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621015177 TIGR01777 family protein; Region: yfcH 234621015178 NAD(P) binding site [chemical binding]; other site 234621015179 active site 234621015180 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 234621015181 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 234621015182 DNA binding residues [nucleotide binding] 234621015183 putative dimer interface [polypeptide binding]; other site 234621015184 short chain dehydrogenase; Provisional; Region: PRK06180 234621015185 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 234621015186 NADP binding site [chemical binding]; other site 234621015187 active site 234621015188 steroid binding site; other site 234621015189 enoyl-CoA hydratase; Provisional; Region: PRK06144 234621015190 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 234621015191 substrate binding site [chemical binding]; other site 234621015192 oxyanion hole (OAH) forming residues; other site 234621015193 trimer interface [polypeptide binding]; other site 234621015194 citrate synthase; Provisional; Region: PRK14033 234621015195 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 234621015196 oxalacetate binding site [chemical binding]; other site 234621015197 citrylCoA binding site [chemical binding]; other site 234621015198 coenzyme A binding site [chemical binding]; other site 234621015199 catalytic triad [active] 234621015200 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 234621015201 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 234621015202 tetramer interface [polypeptide binding]; other site 234621015203 active site 234621015204 Mg2+/Mn2+ binding site [ion binding]; other site 234621015205 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 234621015206 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 234621015207 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234621015208 sequence-specific DNA binding site [nucleotide binding]; other site 234621015209 salt bridge; other site 234621015210 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 234621015211 Domain of unknown function (DUF955); Region: DUF955; pfam06114 234621015212 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 234621015213 Uncharacterized conserved protein [Function unknown]; Region: COG5361 234621015214 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 234621015215 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 234621015216 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621015217 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621015218 active site 234621015219 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 234621015220 CoA-transferase family III; Region: CoA_transf_3; pfam02515 234621015221 Transcriptional regulator [Transcription]; Region: LysR; COG0583 234621015222 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 234621015223 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 234621015224 dimerization interface [polypeptide binding]; other site 234621015225 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 234621015226 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234621015227 dimer interface [polypeptide binding]; other site 234621015228 conserved gate region; other site 234621015229 putative PBP binding loops; other site 234621015230 ABC-ATPase subunit interface; other site 234621015231 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 234621015232 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 234621015233 Walker A/P-loop; other site 234621015234 ATP binding site [chemical binding]; other site 234621015235 Q-loop/lid; other site 234621015236 ABC transporter signature motif; other site 234621015237 Walker B; other site 234621015238 D-loop; other site 234621015239 H-loop/switch region; other site 234621015240 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 234621015241 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 234621015242 Domain of unknown function (DUF202); Region: DUF202; cl09954 234621015243 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 234621015244 putative catalytic site [active] 234621015245 putative metal binding site [ion binding]; other site 234621015246 putative phosphate binding site [ion binding]; other site 234621015247 Domain of unknown function (DUF222); Region: DUF222; pfam02720 234621015248 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 234621015249 active site 234621015250 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 234621015251 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 234621015252 Short C-terminal domain; Region: SHOCT; pfam09851 234621015253 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621015254 putative substrate translocation pore; other site 234621015255 Major Facilitator Superfamily; Region: MFS_1; pfam07690 234621015256 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 234621015257 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 234621015258 active site 234621015259 catalytic tetrad [active] 234621015260 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 234621015261 TIGR03086 family protein; Region: TIGR03086 234621015262 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 234621015263 PhoD-like phosphatase; Region: PhoD; pfam09423 234621015264 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 234621015265 putative active site [active] 234621015266 putative metal binding site [ion binding]; other site 234621015267 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 234621015268 Protein of function (DUF2518); Region: DUF2518; pfam10726 234621015269 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 234621015270 6-phosphogluconate dehydratase; Region: edd; TIGR01196 234621015271 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 234621015272 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 234621015273 cyclase homology domain; Region: CHD; cd07302 234621015274 nucleotidyl binding site; other site 234621015275 metal binding site [ion binding]; metal-binding site 234621015276 dimer interface [polypeptide binding]; other site 234621015277 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621015278 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621015279 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 234621015280 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621015281 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621015282 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 234621015283 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 234621015284 AsnC family; Region: AsnC_trans_reg; pfam01037 234621015285 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 234621015286 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 234621015287 dimer interface [polypeptide binding]; other site 234621015288 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 234621015289 active site 234621015290 Fe binding site [ion binding]; other site 234621015291 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 234621015292 nudix motif; other site 234621015293 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 234621015294 Adenylosuccinate synthetase; Region: Adenylsucc_synt; pfam00709 234621015295 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 234621015296 active site 234621015297 substrate binding site [chemical binding]; other site 234621015298 activation loop (A-loop); other site 234621015299 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 234621015300 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 234621015301 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 234621015302 dimerization interface [polypeptide binding]; other site 234621015303 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621015304 active site 234621015305 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 234621015306 classical (c) SDRs; Region: SDR_c; cd05233 234621015307 NAD(P) binding site [chemical binding]; other site 234621015308 active site 234621015309 short chain dehydrogenase; Provisional; Region: PRK07856 234621015310 classical (c) SDRs; Region: SDR_c; cd05233 234621015311 NAD(P) binding site [chemical binding]; other site 234621015312 active site 234621015313 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 234621015314 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 234621015315 active site 2 [active] 234621015316 active site 1 [active] 234621015317 lipid-transfer protein; Provisional; Region: PRK07855 234621015318 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 234621015319 active site 234621015320 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 234621015321 active site 2 [active] 234621015322 active site 1 [active] 234621015323 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621015324 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 234621015325 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 234621015326 active site 234621015327 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 234621015328 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 234621015329 DUF35 OB-fold domain; Region: DUF35; pfam01796 234621015330 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621015331 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621015332 active site 234621015333 SnoaL-like domain; Region: SnoaL_4; pfam13577 234621015334 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 234621015335 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 234621015336 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 234621015337 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 234621015338 Walker A/P-loop; other site 234621015339 ATP binding site [chemical binding]; other site 234621015340 Q-loop/lid; other site 234621015341 ABC transporter signature motif; other site 234621015342 Walker B; other site 234621015343 D-loop; other site 234621015344 H-loop/switch region; other site 234621015345 NIL domain; Region: NIL; pfam09383 234621015346 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234621015347 dimer interface [polypeptide binding]; other site 234621015348 conserved gate region; other site 234621015349 ABC-ATPase subunit interface; other site 234621015350 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 234621015351 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 234621015352 putative di-iron ligands [ion binding]; other site 234621015353 hypothetical protein; Provisional; Region: PRK01346 234621015354 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 234621015355 Coenzyme A binding pocket [chemical binding]; other site 234621015356 Predicted membrane protein [Function unknown]; Region: COG2246 234621015357 GtrA-like protein; Region: GtrA; pfam04138 234621015358 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 234621015359 DNA binding residues [nucleotide binding] 234621015360 dimerization interface [polypeptide binding]; other site 234621015361 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621015362 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621015363 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 234621015364 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 234621015365 classical (c) SDRs; Region: SDR_c; cd05233 234621015366 NAD(P) binding site [chemical binding]; other site 234621015367 active site 234621015368 acyl-CoA synthetase; Provisional; Region: PRK13388 234621015369 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621015370 acyl-activating enzyme (AAE) consensus motif; other site 234621015371 AMP binding site [chemical binding]; other site 234621015372 active site 234621015373 CoA binding site [chemical binding]; other site 234621015374 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621015375 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 234621015376 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 234621015377 acyl-activating enzyme (AAE) consensus motif; other site 234621015378 acyl-activating enzyme (AAE) consensus motif; other site 234621015379 putative AMP binding site [chemical binding]; other site 234621015380 putative active site [active] 234621015381 putative CoA binding site [chemical binding]; other site 234621015382 SnoaL-like domain; Region: SnoaL_4; pfam13577 234621015383 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 234621015384 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 234621015385 SnoaL-like domain; Region: SnoaL_4; pfam13577 234621015386 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 234621015387 Domain of unknown function (DUF222); Region: DUF222; pfam02720 234621015388 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 234621015389 classical (c) SDRs; Region: SDR_c; cd05233 234621015390 NAD(P) binding site [chemical binding]; other site 234621015391 active site 234621015392 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 234621015393 classical (c) SDRs; Region: SDR_c; cd05233 234621015394 NAD(P) binding site [chemical binding]; other site 234621015395 active site 234621015396 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 234621015397 CoenzymeA binding site [chemical binding]; other site 234621015398 subunit interaction site [polypeptide binding]; other site 234621015399 PHB binding site; other site 234621015400 enoyl-CoA hydratase; Region: PLN02864 234621015401 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 234621015402 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 234621015403 dimer interaction site [polypeptide binding]; other site 234621015404 substrate-binding tunnel; other site 234621015405 active site 234621015406 catalytic site [active] 234621015407 substrate binding site [chemical binding]; other site 234621015408 lipid-transfer protein; Provisional; Region: PRK08256 234621015409 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 234621015410 active site 234621015411 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621015412 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621015413 active site 234621015414 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621015415 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621015416 active site 234621015417 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 234621015418 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 234621015419 dimer interface [polypeptide binding]; other site 234621015420 active site 234621015421 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621015422 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621015423 3-ketosteroid-delta-1-dehydrogenase; Provisional; Region: PRK12837 234621015424 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 234621015425 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 234621015426 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 234621015427 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 234621015428 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 234621015429 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 234621015430 Strictosidine synthase; Region: Str_synth; pfam03088 234621015431 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 234621015432 putative hydrophobic ligand binding site [chemical binding]; other site 234621015433 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 234621015434 dimerization interface [polypeptide binding]; other site 234621015435 putative DNA binding site [nucleotide binding]; other site 234621015436 putative Zn2+ binding site [ion binding]; other site 234621015437 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 234621015438 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 234621015439 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621015440 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 234621015441 Flavin binding site [chemical binding]; other site 234621015442 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 234621015443 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 234621015444 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 234621015445 hydrophobic ligand binding site; other site 234621015446 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621015447 short chain dehydrogenase; Provisional; Region: PRK07454 234621015448 NAD(P) binding site [chemical binding]; other site 234621015449 active site 234621015450 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 234621015451 SnoaL-like domain; Region: SnoaL_3; pfam13474 234621015452 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 234621015453 classical (c) SDRs; Region: SDR_c; cd05233 234621015454 NAD(P) binding site [chemical binding]; other site 234621015455 active site 234621015456 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 234621015457 Coenzyme A binding pocket [chemical binding]; other site 234621015458 Protein of unknown function (DUF1706); Region: DUF1706; cl01748 234621015459 Transposase, Mutator family; Region: Transposase_mut; pfam00872 234621015460 MULE transposase domain; Region: MULE; pfam10551 234621015461 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 234621015462 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 234621015463 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 234621015464 active site 234621015465 dimer interface [polypeptide binding]; other site 234621015466 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 234621015467 Beta-lactamase; Region: Beta-lactamase; pfam00144 234621015468 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 234621015469 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 234621015470 DNA-binding site [nucleotide binding]; DNA binding site 234621015471 UTRA domain; Region: UTRA; pfam07702 234621015472 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 234621015473 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621015474 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621015475 active site 234621015476 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 234621015477 CoA-transferase family III; Region: CoA_transf_3; pfam02515 234621015478 Transcriptional regulator [Transcription]; Region: IclR; COG1414 234621015479 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 234621015480 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 234621015481 Bacterial transcriptional regulator; Region: IclR; pfam01614 234621015482 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 234621015483 Transcriptional regulator [Transcription]; Region: IclR; COG1414 234621015484 Bacterial transcriptional regulator; Region: IclR; pfam01614 234621015485 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 234621015486 active sites [active] 234621015487 tetramer interface [polypeptide binding]; other site 234621015488 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 234621015489 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 234621015490 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234621015491 homodimer interface [polypeptide binding]; other site 234621015492 catalytic residue [active] 234621015493 FAD binding domain; Region: FAD_binding_4; pfam01565 234621015494 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 234621015495 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 234621015496 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 234621015497 Na binding site [ion binding]; other site 234621015498 urocanate hydratase; Provisional; Region: PRK05414 234621015499 imidazolonepropionase; Provisional; Region: PRK14085 234621015500 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 234621015501 active site 234621015502 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 234621015503 putative active site [active] 234621015504 putative metal binding site [ion binding]; other site 234621015505 tetracycline repressor protein TetR; Provisional; Region: PRK13756 234621015506 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621015507 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 234621015508 Domain of unknown function (DUF385); Region: DUF385; cl04387 234621015509 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621015510 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621015511 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 234621015512 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 234621015513 Walker A/P-loop; other site 234621015514 ATP binding site [chemical binding]; other site 234621015515 Q-loop/lid; other site 234621015516 ABC transporter signature motif; other site 234621015517 Walker B; other site 234621015518 D-loop; other site 234621015519 H-loop/switch region; other site 234621015520 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 234621015521 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 234621015522 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 234621015523 active site 234621015524 iron coordination sites [ion binding]; other site 234621015525 substrate binding pocket [chemical binding]; other site 234621015526 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 234621015527 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 234621015528 DNA binding residues [nucleotide binding] 234621015529 TAP-like protein; Region: Abhydrolase_4; pfam08386 234621015530 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 234621015531 Transcriptional regulator [Transcription]; Region: IclR; COG1414 234621015532 Bacterial transcriptional regulator; Region: IclR; pfam01614 234621015533 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 234621015534 classical (c) SDRs; Region: SDR_c; cd05233 234621015535 NAD(P) binding site [chemical binding]; other site 234621015536 active site 234621015537 dihydroxy-acid dehydratase; Validated; Region: PRK06131 234621015538 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 234621015539 DAK2 domain; Region: Dak2; pfam02734 234621015540 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 234621015541 Dak1 domain; Region: Dak1; pfam02733 234621015542 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 234621015543 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 234621015544 classical (c) SDRs; Region: SDR_c; cd05233 234621015545 NAD(P) binding site [chemical binding]; other site 234621015546 active site 234621015547 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 234621015548 dimer interface [polypeptide binding]; other site 234621015549 substrate binding site [chemical binding]; other site 234621015550 metal binding site [ion binding]; metal-binding site 234621015551 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 234621015552 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621015553 putative substrate translocation pore; other site 234621015554 acyl-CoA synthetase; Validated; Region: PRK06188 234621015555 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621015556 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 234621015557 acyl-activating enzyme (AAE) consensus motif; other site 234621015558 acyl-activating enzyme (AAE) consensus motif; other site 234621015559 putative AMP binding site [chemical binding]; other site 234621015560 putative active site [active] 234621015561 putative CoA binding site [chemical binding]; other site 234621015562 Uncharacterized conserved protein [Function unknown]; Region: COG3268 234621015563 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 234621015564 classical (c) SDRs; Region: SDR_c; cd05233 234621015565 NAD(P) binding site [chemical binding]; other site 234621015566 active site 234621015567 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621015568 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621015569 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 234621015570 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621015571 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621015572 enoyl-CoA hydratase; Provisional; Region: PRK08252 234621015573 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 234621015574 substrate binding site [chemical binding]; other site 234621015575 oxyanion hole (OAH) forming residues; other site 234621015576 trimer interface [polypeptide binding]; other site 234621015577 OsmC-like protein; Region: OsmC; pfam02566 234621015578 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 234621015579 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 234621015580 homodimer interface [polypeptide binding]; other site 234621015581 substrate-cofactor binding pocket; other site 234621015582 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234621015583 catalytic residue [active] 234621015584 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 234621015585 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 234621015586 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 234621015587 active site 234621015588 Fe binding site [ion binding]; other site 234621015589 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621015590 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621015591 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 234621015592 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 234621015593 Transcriptional regulator [Transcription]; Region: IclR; COG1414 234621015594 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 234621015595 Bacterial transcriptional regulator; Region: IclR; pfam01614 234621015596 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 234621015597 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 234621015598 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 234621015599 SnoaL-like domain; Region: SnoaL_4; pfam13577 234621015600 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 234621015601 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 234621015602 acyl-CoA synthetase; Validated; Region: PRK07798 234621015603 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621015604 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 234621015605 acyl-activating enzyme (AAE) consensus motif; other site 234621015606 putative AMP binding site [chemical binding]; other site 234621015607 putative active site [active] 234621015608 putative CoA binding site [chemical binding]; other site 234621015609 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621015610 NAD(P) binding site [chemical binding]; other site 234621015611 active site 234621015612 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 234621015613 classical (c) SDRs; Region: SDR_c; cd05233 234621015614 NAD(P) binding site [chemical binding]; other site 234621015615 active site 234621015616 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 234621015617 active site 234621015618 SnoaL-like domain; Region: SnoaL_4; pfam13577 234621015619 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 234621015620 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 234621015621 putative active site [active] 234621015622 putative FMN binding site [chemical binding]; other site 234621015623 putative substrate binding site [chemical binding]; other site 234621015624 putative catalytic residue [active] 234621015625 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 234621015626 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 234621015627 NADP binding site [chemical binding]; other site 234621015628 dimer interface [polypeptide binding]; other site 234621015629 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 234621015630 RNA/DNA hybrid binding site [nucleotide binding]; other site 234621015631 active site 234621015632 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 234621015633 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 234621015634 minor groove reading motif; other site 234621015635 helix-hairpin-helix signature motif; other site 234621015636 active site 234621015637 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 234621015638 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 234621015639 putative DNA binding site [nucleotide binding]; other site 234621015640 putative Zn2+ binding site [ion binding]; other site 234621015641 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 234621015642 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 234621015643 dimer interface [polypeptide binding]; other site 234621015644 active site 234621015645 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 234621015646 putative active site [active] 234621015647 putative catalytic site [active] 234621015648 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 234621015649 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 234621015650 DNA-binding site [nucleotide binding]; DNA binding site 234621015651 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 234621015652 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621015653 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621015654 active site 234621015655 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 234621015656 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 234621015657 putative active site [active] 234621015658 putative catalytic site [active] 234621015659 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 234621015660 active site 2 [active] 234621015661 active site 1 [active] 234621015662 mesaconyl-CoA isomerase; Region: mesacon_CoA_iso; TIGR04253 234621015663 CoA-transferase family III; Region: CoA_transf_3; pfam02515 234621015664 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621015665 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621015666 active site 234621015667 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621015668 D-galactonate transporter; Region: 2A0114; TIGR00893 234621015669 putative substrate translocation pore; other site 234621015670 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 234621015671 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 234621015672 dimer interface [polypeptide binding]; other site 234621015673 active site 234621015674 short chain dehydrogenase; Provisional; Region: PRK12828 234621015675 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621015676 NAD(P) binding site [chemical binding]; other site 234621015677 active site 234621015678 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 234621015679 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621015680 acyl-activating enzyme (AAE) consensus motif; other site 234621015681 AMP binding site [chemical binding]; other site 234621015682 active site 234621015683 CoA binding site [chemical binding]; other site 234621015684 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 234621015685 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 234621015686 FMN binding site [chemical binding]; other site 234621015687 substrate binding site [chemical binding]; other site 234621015688 putative catalytic residue [active] 234621015689 Transcriptional regulator [Transcription]; Region: LysR; COG0583 234621015690 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 234621015691 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 234621015692 dimerization interface [polypeptide binding]; other site 234621015693 Transcriptional regulator [Transcription]; Region: LysR; COG0583 234621015694 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 234621015695 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 234621015696 dimerization interface [polypeptide binding]; other site 234621015697 enoyl-CoA hydratase; Provisional; Region: PRK06688 234621015698 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 234621015699 substrate binding site [chemical binding]; other site 234621015700 oxyanion hole (OAH) forming residues; other site 234621015701 trimer interface [polypeptide binding]; other site 234621015702 enoyl-CoA hydratase; Provisional; Region: PRK08252 234621015703 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 234621015704 substrate binding site [chemical binding]; other site 234621015705 oxyanion hole (OAH) forming residues; other site 234621015706 trimer interface [polypeptide binding]; other site 234621015707 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 234621015708 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 234621015709 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621015710 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 234621015711 acyl-activating enzyme (AAE) consensus motif; other site 234621015712 putative AMP binding site [chemical binding]; other site 234621015713 putative active site [active] 234621015714 putative CoA binding site [chemical binding]; other site 234621015715 Transcriptional regulator [Transcription]; Region: LysR; COG0583 234621015716 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 234621015717 dimerization interface [polypeptide binding]; other site 234621015718 Transcriptional regulator [Transcription]; Region: LysR; COG0583 234621015719 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 234621015720 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 234621015721 dimerization interface [polypeptide binding]; other site 234621015722 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 234621015723 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 234621015724 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 234621015725 active site 234621015726 metal binding site [ion binding]; metal-binding site 234621015727 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621015728 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621015729 active site 234621015730 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 234621015731 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 234621015732 dimer interface [polypeptide binding]; other site 234621015733 active site 234621015734 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 234621015735 CoA-transferase family III; Region: CoA_transf_3; pfam02515 234621015736 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 234621015737 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621015738 NAD(P) binding site [chemical binding]; other site 234621015739 active site 234621015740 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621015741 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621015742 active site 234621015743 acyl-CoA synthetase; Validated; Region: PRK08316 234621015744 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621015745 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 234621015746 acyl-activating enzyme (AAE) consensus motif; other site 234621015747 acyl-activating enzyme (AAE) consensus motif; other site 234621015748 putative AMP binding site [chemical binding]; other site 234621015749 putative active site [active] 234621015750 putative CoA binding site [chemical binding]; other site 234621015751 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 234621015752 enoyl-CoA hydratase; Validated; Region: PRK08139 234621015753 substrate binding site [chemical binding]; other site 234621015754 oxyanion hole (OAH) forming residues; other site 234621015755 trimer interface [polypeptide binding]; other site 234621015756 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 234621015757 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 234621015758 NAD(P) binding site [chemical binding]; other site 234621015759 catalytic residues [active] 234621015760 SEC-C motif; Region: SEC-C; pfam02810 234621015761 SEC-C motif; Region: SEC-C; pfam02810 234621015762 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 234621015763 hypothetical protein; Validated; Region: PRK07586 234621015764 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 234621015765 PYR/PP interface [polypeptide binding]; other site 234621015766 dimer interface [polypeptide binding]; other site 234621015767 TPP binding site [chemical binding]; other site 234621015768 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 234621015769 TPP-binding site [chemical binding]; other site 234621015770 dimer interface [polypeptide binding]; other site 234621015771 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 234621015772 enoyl-CoA hydratase; Provisional; Region: PRK06688 234621015773 substrate binding site [chemical binding]; other site 234621015774 oxyanion hole (OAH) forming residues; other site 234621015775 trimer interface [polypeptide binding]; other site 234621015776 spermidine synthase; Provisional; Region: PRK03612 234621015777 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234621015778 S-adenosylmethionine binding site [chemical binding]; other site 234621015779 Predicted membrane protein [Function unknown]; Region: COG3766 234621015780 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 234621015781 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 234621015782 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 234621015783 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 234621015784 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 234621015785 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 234621015786 Protein of unknown function (DUF3533); Region: DUF3533; pfam12051 234621015787 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 234621015788 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 234621015789 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 234621015790 NAD(P) binding site [chemical binding]; other site 234621015791 catalytic residues [active] 234621015792 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 234621015793 MarR family; Region: MarR; pfam01047 234621015794 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 234621015795 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 234621015796 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 234621015797 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 234621015798 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 234621015799 active site 234621015800 DNA binding site [nucleotide binding] 234621015801 catalytic site [active] 234621015802 MMPL family; Region: MMPL; pfam03176 234621015803 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 234621015804 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 234621015805 AlkA N-terminal domain; Region: AlkA_N; pfam06029 234621015806 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 234621015807 minor groove reading motif; other site 234621015808 helix-hairpin-helix signature motif; other site 234621015809 substrate binding pocket [chemical binding]; other site 234621015810 active site 234621015811 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 234621015812 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 234621015813 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 234621015814 DNA binding site [nucleotide binding] 234621015815 active site 234621015816 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 234621015817 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234621015818 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234621015819 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 234621015820 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 234621015821 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 234621015822 DNA binding site [nucleotide binding] 234621015823 active site 234621015824 short chain dehydrogenase; Provisional; Region: PRK07326 234621015825 classical (c) SDRs; Region: SDR_c; cd05233 234621015826 NAD(P) binding site [chemical binding]; other site 234621015827 active site 234621015828 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 234621015829 putative active site [active] 234621015830 putative substrate binding site [chemical binding]; other site 234621015831 ATP binding site [chemical binding]; other site 234621015832 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621015833 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 234621015834 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 234621015835 active site 234621015836 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 234621015837 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 234621015838 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234621015839 Walker A/P-loop; other site 234621015840 ATP binding site [chemical binding]; other site 234621015841 Q-loop/lid; other site 234621015842 ABC transporter signature motif; other site 234621015843 Walker B; other site 234621015844 D-loop; other site 234621015845 H-loop/switch region; other site 234621015846 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621015847 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621015848 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 234621015849 DNA binding residues [nucleotide binding] 234621015850 dimerization interface [polypeptide binding]; other site 234621015851 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 234621015852 Short C-terminal domain; Region: SHOCT; pfam09851 234621015853 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 234621015854 Uncharacterized conserved protein [Function unknown]; Region: COG5361 234621015855 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 234621015856 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 234621015857 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 234621015858 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 234621015859 EamA-like transporter family; Region: EamA; pfam00892 234621015860 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621015861 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621015862 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621015863 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621015864 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 234621015865 hydrophobic ligand binding site; other site 234621015866 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621015867 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621015868 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 234621015869 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621015870 NAD(P) binding site [chemical binding]; other site 234621015871 active site 234621015872 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621015873 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621015874 active site 234621015875 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621015876 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621015877 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 234621015878 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234621015879 DNA binding residues [nucleotide binding] 234621015880 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 234621015881 binding surface 234621015882 YCII-related domain; Region: YCII; cl00999 234621015883 Domain of unknown function (DUF309); Region: DUF309; pfam03745 234621015884 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 234621015885 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 234621015886 classical (c) SDRs; Region: SDR_c; cd05233 234621015887 NAD(P) binding site [chemical binding]; other site 234621015888 active site 234621015889 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 234621015890 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 234621015891 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 234621015892 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 234621015893 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 234621015894 Cysteine-rich domain; Region: CCG; pfam02754 234621015895 Cysteine-rich domain; Region: CCG; pfam02754 234621015896 transcriptional regulator NanR; Provisional; Region: PRK03837 234621015897 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 234621015898 DNA-binding site [nucleotide binding]; DNA binding site 234621015899 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 234621015900 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 234621015901 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 234621015902 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: Php; COG1735 234621015903 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 234621015904 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 234621015905 TM-ABC transporter signature motif; other site 234621015906 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 234621015907 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 234621015908 Walker A/P-loop; other site 234621015909 ATP binding site [chemical binding]; other site 234621015910 Q-loop/lid; other site 234621015911 ABC transporter signature motif; other site 234621015912 Walker B; other site 234621015913 D-loop; other site 234621015914 H-loop/switch region; other site 234621015915 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 234621015916 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 234621015917 ligand binding site [chemical binding]; other site 234621015918 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 234621015919 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 234621015920 BtpA family; Region: BtpA; cl00440 234621015921 Transcriptional regulators [Transcription]; Region: PurR; COG1609 234621015922 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 234621015923 DNA binding site [nucleotide binding] 234621015924 domain linker motif; other site 234621015925 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 234621015926 dimerization interface [polypeptide binding]; other site 234621015927 ligand binding site [chemical binding]; other site 234621015928 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 234621015929 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 234621015930 metal binding site [ion binding]; metal-binding site 234621015931 dimer interface [polypeptide binding]; other site 234621015932 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 234621015933 active site 234621015934 catalytic site [active] 234621015935 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 234621015936 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 234621015937 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 234621015938 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 234621015939 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 234621015940 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 234621015941 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 234621015942 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 234621015943 active site 234621015944 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 234621015945 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 234621015946 active site 234621015947 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 234621015948 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 234621015949 tetramer interface [polypeptide binding]; other site 234621015950 active site 234621015951 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 234621015952 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 234621015953 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 234621015954 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 234621015955 Bacterial transcriptional regulator; Region: IclR; pfam01614 234621015956 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 234621015957 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 234621015958 dimer interface [polypeptide binding]; other site 234621015959 active site 234621015960 Transcriptional regulators [Transcription]; Region: MarR; COG1846 234621015961 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 234621015962 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 234621015963 classical (c) SDRs; Region: SDR_c; cd05233 234621015964 NAD(P) binding site [chemical binding]; other site 234621015965 active site 234621015966 Dienelactone hydrolase family; Region: DLH; pfam01738 234621015967 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 234621015968 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 234621015969 intersubunit interface [polypeptide binding]; other site 234621015970 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 234621015971 DNA-binding site [nucleotide binding]; DNA binding site 234621015972 RNA-binding motif; other site 234621015973 Clp amino terminal domain; Region: Clp_N; pfam02861 234621015974 Clp amino terminal domain; Region: Clp_N; pfam02861 234621015975 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 234621015976 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 234621015977 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 234621015978 intersubunit interface [polypeptide binding]; other site 234621015979 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 234621015980 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 234621015981 Mechanosensitive ion channel; Region: MS_channel; pfam00924 234621015982 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 234621015983 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 234621015984 Na binding site [ion binding]; other site 234621015985 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 234621015986 nucleoside/Zn binding site; other site 234621015987 dimer interface [polypeptide binding]; other site 234621015988 catalytic motif [active] 234621015989 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 234621015990 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 234621015991 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 234621015992 Uncharacterized conserved protein [Function unknown]; Region: COG1262 234621015993 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 234621015994 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 234621015995 AAA domain; Region: AAA_17; pfam13207 234621015996 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 234621015997 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 234621015998 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 234621015999 Ligand binding site; other site 234621016000 metal-binding site 234621016001 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 234621016002 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 234621016003 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 234621016004 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_6; cd07824 234621016005 putative hydrophobic ligand binding site [chemical binding]; other site 234621016006 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 234621016007 ATP-binding site [chemical binding]; other site 234621016008 Gluconate-6-phosphate binding site [chemical binding]; other site 234621016009 fructuronate transporter; Provisional; Region: PRK10034; cl15264 234621016010 Transcriptional regulators [Transcription]; Region: FadR; COG2186 234621016011 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 234621016012 DNA-binding site [nucleotide binding]; DNA binding site 234621016013 FCD domain; Region: FCD; pfam07729 234621016014 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439 234621016015 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 234621016016 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 234621016017 short chain dehydrogenase; Provisional; Region: PRK08278 234621016018 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621016019 NAD(P) binding site [chemical binding]; other site 234621016020 active site 234621016021 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 234621016022 AAA ATPase domain; Region: AAA_16; pfam13191 234621016023 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 234621016024 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 234621016025 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 234621016026 active site 2 [active] 234621016027 active site 1 [active] 234621016028 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 234621016029 active site 234621016030 catalytic site [active] 234621016031 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621016032 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621016033 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 234621016034 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 234621016035 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234621016036 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621016037 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621016038 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 234621016039 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 234621016040 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 234621016041 putative NAD(P) binding site [chemical binding]; other site 234621016042 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 234621016043 TAP-like protein; Region: Abhydrolase_4; pfam08386 234621016044 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 234621016045 ABC1 family; Region: ABC1; cl17513 234621016046 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 234621016047 active site 234621016048 ATP binding site [chemical binding]; other site 234621016049 acyl-CoA synthetase; Validated; Region: PRK07798 234621016050 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621016051 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 234621016052 acyl-activating enzyme (AAE) consensus motif; other site 234621016053 putative AMP binding site [chemical binding]; other site 234621016054 putative active site [active] 234621016055 putative CoA binding site [chemical binding]; other site 234621016056 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 234621016057 CGNR zinc finger; Region: zf-CGNR; pfam11706 234621016058 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 234621016059 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 234621016060 active site 234621016061 dimer interface [polypeptide binding]; other site 234621016062 non-prolyl cis peptide bond; other site 234621016063 insertion regions; other site 234621016064 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621016065 metabolite-proton symporter; Region: 2A0106; TIGR00883 234621016066 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 234621016067 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621016068 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621016069 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 234621016070 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 234621016071 FAD binding domain; Region: FAD_binding_2; pfam00890 234621016072 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 234621016073 Sulfatase; Region: Sulfatase; pfam00884 234621016074 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 234621016075 Predicted membrane protein [Function unknown]; Region: COG4325 234621016076 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 234621016077 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 234621016078 diiron binding motif [ion binding]; other site 234621016079 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 234621016080 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 234621016081 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 234621016082 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 234621016083 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 234621016084 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234621016085 Walker A/P-loop; other site 234621016086 ATP binding site [chemical binding]; other site 234621016087 Q-loop/lid; other site 234621016088 ABC transporter signature motif; other site 234621016089 Walker B; other site 234621016090 D-loop; other site 234621016091 H-loop/switch region; other site 234621016092 Predicted transcriptional regulators [Transcription]; Region: COG1725 234621016093 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 234621016094 DNA-binding site [nucleotide binding]; DNA binding site 234621016095 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 234621016096 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 234621016097 putative binding site residues; other site 234621016098 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 234621016099 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 234621016100 putative PBP binding regions; other site 234621016101 ABC-ATPase subunit interface; other site 234621016102 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 234621016103 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 234621016104 Walker A/P-loop; other site 234621016105 ATP binding site [chemical binding]; other site 234621016106 Q-loop/lid; other site 234621016107 ABC transporter signature motif; other site 234621016108 Walker B; other site 234621016109 D-loop; other site 234621016110 H-loop/switch region; other site 234621016111 putative hydrolase; Provisional; Region: PRK02113 234621016112 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 234621016113 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 234621016114 homotrimer interface [polypeptide binding]; other site 234621016115 Walker A motif; other site 234621016116 GTP binding site [chemical binding]; other site 234621016117 Walker B motif; other site 234621016118 Transcriptional regulator [Transcription]; Region: IclR; COG1414 234621016119 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 234621016120 Bacterial transcriptional regulator; Region: IclR; pfam01614 234621016121 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 234621016122 Methylamine utilisation protein MauE; Region: MauE; pfam07291 234621016123 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 234621016124 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 234621016125 Methylamine dehydrogenase, L chain; Region: Me-amine-dh_L; cl03812 234621016126 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 234621016127 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 234621016128 Multicopper oxidase; Region: Cu-oxidase; pfam00394 234621016129 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 234621016130 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 234621016131 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 234621016132 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 234621016133 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 234621016134 putative active site [active] 234621016135 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 234621016136 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 234621016137 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234621016138 Walker A/P-loop; other site 234621016139 ATP binding site [chemical binding]; other site 234621016140 Q-loop/lid; other site 234621016141 ABC transporter signature motif; other site 234621016142 Walker B; other site 234621016143 D-loop; other site 234621016144 H-loop/switch region; other site 234621016145 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 234621016146 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 234621016147 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234621016148 Walker A/P-loop; other site 234621016149 ATP binding site [chemical binding]; other site 234621016150 Q-loop/lid; other site 234621016151 ABC transporter signature motif; other site 234621016152 Walker B; other site 234621016153 D-loop; other site 234621016154 H-loop/switch region; other site 234621016155 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 234621016156 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 234621016157 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 234621016158 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 234621016159 Multicopper oxidase; Region: Cu-oxidase; pfam00394 234621016160 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 234621016161 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 234621016162 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 234621016163 intersubunit interface [polypeptide binding]; other site 234621016164 Secretory lipase; Region: LIP; pfam03583 234621016165 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 234621016166 putative dimer interface [polypeptide binding]; other site 234621016167 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621016168 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621016169 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 234621016170 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 234621016171 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 234621016172 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 234621016173 CoenzymeA binding site [chemical binding]; other site 234621016174 subunit interaction site [polypeptide binding]; other site 234621016175 PHB binding site; other site 234621016176 Predicted transcriptional regulators [Transcription]; Region: COG1733 234621016177 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 234621016178 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 234621016179 Protein of unknown function DUF72; Region: DUF72; pfam01904 234621016180 GYD domain; Region: GYD; pfam08734 234621016181 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 234621016182 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 234621016183 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621016184 NADH(P)-binding; Region: NAD_binding_10; pfam13460 234621016185 NAD(P) binding site [chemical binding]; other site 234621016186 active site 234621016187 Rrf2 family protein; Region: rrf2_super; TIGR00738 234621016188 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 234621016189 dimerization interface [polypeptide binding]; other site 234621016190 putative Zn2+ binding site [ion binding]; other site 234621016191 putative DNA binding site [nucleotide binding]; other site 234621016192 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 234621016193 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 234621016194 metal binding site [ion binding]; metal-binding site 234621016195 active site 234621016196 I-site; other site 234621016197 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234621016198 salt bridge; other site 234621016199 non-specific DNA binding site [nucleotide binding]; other site 234621016200 sequence-specific DNA binding site [nucleotide binding]; other site 234621016201 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 234621016202 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 234621016203 catalytic Zn binding site [ion binding]; other site 234621016204 NAD(P) binding site [chemical binding]; other site 234621016205 structural Zn binding site [ion binding]; other site 234621016206 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621016207 Major Facilitator Superfamily; Region: MFS_1; pfam07690 234621016208 putative substrate translocation pore; other site 234621016209 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621016210 Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; cl01788 234621016211 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 234621016212 LexA repressor; Validated; Region: PRK00215 234621016213 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 234621016214 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 234621016215 Catalytic site [active] 234621016216 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 234621016217 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 234621016218 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 234621016219 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 234621016220 DNA binding residues [nucleotide binding] 234621016221 dimerization interface [polypeptide binding]; other site 234621016222 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 234621016223 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 234621016224 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621016225 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621016226 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 234621016227 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621016228 NAD(P) binding site [chemical binding]; other site 234621016229 active site 234621016230 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 234621016231 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 234621016232 dimerization interface [polypeptide binding]; other site 234621016233 putative DNA binding site [nucleotide binding]; other site 234621016234 putative Zn2+ binding site [ion binding]; other site 234621016235 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 234621016236 putative hydrophobic ligand binding site [chemical binding]; other site 234621016237 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 234621016238 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234621016239 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 234621016240 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 234621016241 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 234621016242 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 234621016243 intersubunit interface [polypeptide binding]; other site 234621016244 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621016245 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621016246 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 234621016247 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 234621016248 DNA binding residues [nucleotide binding] 234621016249 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 234621016250 ABC1 family; Region: ABC1; cl17513 234621016251 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 234621016252 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 234621016253 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 234621016254 NAD binding site [chemical binding]; other site 234621016255 catalytic Zn binding site [ion binding]; other site 234621016256 substrate binding site [chemical binding]; other site 234621016257 structural Zn binding site [ion binding]; other site 234621016258 Putative esterase; Region: Esterase; pfam00756 234621016259 Domain of unknown function (DUF336); Region: DUF336; pfam03928 234621016260 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 234621016261 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 234621016262 ATP binding site [chemical binding]; other site 234621016263 Mg2+ binding site [ion binding]; other site 234621016264 G-X-G motif; other site 234621016265 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 234621016266 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234621016267 active site 234621016268 phosphorylation site [posttranslational modification] 234621016269 intermolecular recognition site; other site 234621016270 dimerization interface [polypeptide binding]; other site 234621016271 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 234621016272 dimerization interface [polypeptide binding]; other site 234621016273 DNA binding residues [nucleotide binding] 234621016274 Muconolactone delta-isomerase; Region: MIase; pfam02426 234621016275 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 234621016276 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 234621016277 octamer interface [polypeptide binding]; other site 234621016278 active site 234621016279 catechol 1,2-dioxygenase, Actinobacterial; Region: catachol_actin; TIGR02438 234621016280 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 234621016281 active site 234621016282 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 234621016283 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 234621016284 Bacterial transcriptional regulator; Region: IclR; pfam01614 234621016285 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 234621016286 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 234621016287 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 234621016288 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 234621016289 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 234621016290 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 234621016291 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 234621016292 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 234621016293 dimer interface [polypeptide binding]; other site 234621016294 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234621016295 HTH domain; Region: HTH_11; pfam08279 234621016296 WYL domain; Region: WYL; pfam13280 234621016297 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621016298 putative substrate translocation pore; other site 234621016299 Major Facilitator Superfamily; Region: MFS_1; pfam07690 234621016300 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621016301 Transcriptional regulators [Transcription]; Region: FadR; COG2186 234621016302 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 234621016303 DNA-binding site [nucleotide binding]; DNA binding site 234621016304 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 234621016305 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621016306 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621016307 2-epi-5-epi-valiolone synthase (EEVS); Region: EEVS; cd08199 234621016308 active site 234621016309 metal binding site [ion binding]; metal-binding site 234621016310 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 234621016311 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 234621016312 dimer interface [polypeptide binding]; other site 234621016313 active site 234621016314 MFS transport protein AraJ; Provisional; Region: PRK10091 234621016315 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621016316 putative substrate translocation pore; other site 234621016317 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 234621016318 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 234621016319 NAD(P) binding site [chemical binding]; other site 234621016320 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621016321 NAD(P) binding site [chemical binding]; other site 234621016322 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621016323 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 234621016324 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 234621016325 putative NAD(P) binding site [chemical binding]; other site 234621016326 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 234621016327 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234621016328 active site 234621016329 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 234621016330 active site 234621016331 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 234621016332 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 234621016333 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 234621016334 haloacid dehalogenase superfamily, subfamily IA hydrolase, TIGR01548; Region: HAD-SF-IA-hyp1 234621016335 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 234621016336 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 234621016337 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 234621016338 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 234621016339 NAD(P) binding site [chemical binding]; other site 234621016340 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 234621016341 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621016342 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621016343 WHG domain; Region: WHG; pfam13305 234621016344 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 234621016345 NADP binding site [chemical binding]; other site 234621016346 active site 234621016347 substrate binding site [chemical binding]; other site 234621016348 homodimer interface [polypeptide binding]; other site 234621016349 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 234621016350 Beta-lactamase; Region: Beta-lactamase; pfam00144 234621016351 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 234621016352 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 234621016353 threonine dehydratase; Provisional; Region: PRK08246 234621016354 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 234621016355 catalytic residue [active] 234621016356 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621016357 NADH(P)-binding; Region: NAD_binding_10; pfam13460 234621016358 NAD(P) binding site [chemical binding]; other site 234621016359 active site 234621016360 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 234621016361 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 234621016362 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 234621016363 Fatty acid desaturase; Region: FA_desaturase; pfam00487 234621016364 Di-iron ligands [ion binding]; other site 234621016365 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 234621016366 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 234621016367 intersubunit interface [polypeptide binding]; other site 234621016368 Cupin domain; Region: Cupin_2; pfam07883 234621016369 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 234621016370 D-cysteine desulfhydrase; Validated; Region: PRK03910 234621016371 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 234621016372 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 234621016373 catalytic residue [active] 234621016374 Dienelactone hydrolase family; Region: DLH; pfam01738 234621016375 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 234621016376 Protein of unknown function (DUF3353); Region: DUF3353; pfam11833 234621016377 Kynureninase [Amino acid transport and metabolism]; Region: COG3844 234621016378 kynureninase; Region: kynureninase; TIGR01814 234621016379 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 234621016380 catalytic residue [active] 234621016381 Putative cyclase; Region: Cyclase; cl00814 234621016382 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 234621016383 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 234621016384 putative DNA binding site [nucleotide binding]; other site 234621016385 putative Zn2+ binding site [ion binding]; other site 234621016386 AsnC family; Region: AsnC_trans_reg; pfam01037 234621016387 Phosphotransferase enzyme family; Region: APH; pfam01636 234621016388 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 234621016389 active site 234621016390 ATP binding site [chemical binding]; other site 234621016391 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 234621016392 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 234621016393 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 234621016394 NAD binding site [chemical binding]; other site 234621016395 catalytic Zn binding site [ion binding]; other site 234621016396 substrate binding site [chemical binding]; other site 234621016397 structural Zn binding site [ion binding]; other site 234621016398 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 234621016399 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 234621016400 DNA binding residues [nucleotide binding] 234621016401 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 234621016402 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 234621016403 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 234621016404 catalytic triad [active] 234621016405 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 234621016406 aspartate racemase; Region: asp_race; TIGR00035 234621016407 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 234621016408 Transcriptional regulators [Transcription]; Region: GntR; COG1802 234621016409 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 234621016410 DNA-binding site [nucleotide binding]; DNA binding site 234621016411 FCD domain; Region: FCD; pfam07729 234621016412 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 234621016413 dimerization interface [polypeptide binding]; other site 234621016414 putative DNA binding site [nucleotide binding]; other site 234621016415 putative Zn2+ binding site [ion binding]; other site 234621016416 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 234621016417 putative hydrophobic ligand binding site [chemical binding]; other site 234621016418 Predicted membrane protein [Function unknown]; Region: COG1511 234621016419 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 234621016420 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 234621016421 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 234621016422 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 234621016423 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 234621016424 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 234621016425 RhlG and related beta-ketoacyl reductases, classical (c) SDRs; Region: RhlG_SDR_c; cd08942 234621016426 NADP binding site [chemical binding]; other site 234621016427 active site 234621016428 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 234621016429 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 234621016430 dimer interface [polypeptide binding]; other site 234621016431 active site 234621016432 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 234621016433 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 234621016434 NAD(P) binding site [chemical binding]; other site 234621016435 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621016436 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 234621016437 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621016438 active site 234621016439 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 234621016440 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621016441 FAD binding site [chemical binding]; other site 234621016442 substrate binding site [chemical binding]; other site 234621016443 catalytic base [active] 234621016444 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 234621016445 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621016446 NAD(P) binding site [chemical binding]; other site 234621016447 active site 234621016448 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 234621016449 putative active site [active] 234621016450 putative substrate binding site [chemical binding]; other site 234621016451 ATP binding site [chemical binding]; other site 234621016452 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 234621016453 classical (c) SDRs; Region: SDR_c; cd05233 234621016454 NAD(P) binding site [chemical binding]; other site 234621016455 active site 234621016456 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621016457 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621016458 active site 234621016459 enoyl-CoA hydratase; Provisional; Region: PRK06210 234621016460 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 234621016461 substrate binding site [chemical binding]; other site 234621016462 oxyanion hole (OAH) forming residues; other site 234621016463 trimer interface [polypeptide binding]; other site 234621016464 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 234621016465 classical (c) SDRs; Region: SDR_c; cd05233 234621016466 NAD(P) binding site [chemical binding]; other site 234621016467 active site 234621016468 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 234621016469 putative active site [active] 234621016470 putative catalytic site [active] 234621016471 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621016472 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621016473 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 234621016474 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 234621016475 acyl-activating enzyme (AAE) consensus motif; other site 234621016476 putative AMP binding site [chemical binding]; other site 234621016477 putative active site [active] 234621016478 putative CoA binding site [chemical binding]; other site 234621016479 Uncharacterized conserved protein [Function unknown]; Region: COG1359 234621016480 epoxide hydrolase N-terminal domain-like phosphatase; Region: HAD-1A3-hyp; TIGR02247 234621016481 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 234621016482 motif I; other site 234621016483 motif II; other site 234621016484 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621016485 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621016486 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621016487 metabolite-proton symporter; Region: 2A0106; TIGR00883 234621016488 putative substrate translocation pore; other site 234621016489 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 234621016490 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 234621016491 acyl-activating enzyme (AAE) consensus motif; other site 234621016492 putative AMP binding site [chemical binding]; other site 234621016493 putative active site [active] 234621016494 putative CoA binding site [chemical binding]; other site 234621016495 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 234621016496 active site 234621016497 substrate binding pocket [chemical binding]; other site 234621016498 homodimer interaction site [polypeptide binding]; other site 234621016499 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621016500 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621016501 Transcriptional regulators [Transcription]; Region: FadR; COG2186 234621016502 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 234621016503 DNA-binding site [nucleotide binding]; DNA binding site 234621016504 FCD domain; Region: FCD; pfam07729 234621016505 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 234621016506 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234621016507 Walker A/P-loop; other site 234621016508 ATP binding site [chemical binding]; other site 234621016509 Q-loop/lid; other site 234621016510 ABC transporter signature motif; other site 234621016511 Walker B; other site 234621016512 D-loop; other site 234621016513 H-loop/switch region; other site 234621016514 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 234621016515 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 234621016516 DNA binding residues [nucleotide binding] 234621016517 dimer interface [polypeptide binding]; other site 234621016518 [2Fe-2S] cluster binding site [ion binding]; other site 234621016519 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621016520 putative substrate translocation pore; other site 234621016521 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 234621016522 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 234621016523 metal binding site [ion binding]; metal-binding site 234621016524 active site 234621016525 I-site; other site 234621016526 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 234621016527 Beta-lactamase; Region: Beta-lactamase; pfam00144 234621016528 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 234621016529 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621016530 Transcriptional regulators [Transcription]; Region: GntR; COG1802 234621016531 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 234621016532 DNA-binding site [nucleotide binding]; DNA binding site 234621016533 FCD domain; Region: FCD; pfam07729 234621016534 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621016535 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 234621016536 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 234621016537 active site 234621016538 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 234621016539 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 234621016540 NAD(P) binding site [chemical binding]; other site 234621016541 catalytic residues [active] 234621016542 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 234621016543 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 234621016544 active site 234621016545 dimer interface [polypeptide binding]; other site 234621016546 non-prolyl cis peptide bond; other site 234621016547 insertion regions; other site 234621016548 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 234621016549 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621016550 active site 234621016551 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 234621016552 DNA-binding interface [nucleotide binding]; DNA binding site 234621016553 tetracycline repressor protein TetR; Provisional; Region: PRK13756 234621016554 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 234621016555 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621016556 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621016557 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 234621016558 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 234621016559 intersubunit interface [polypeptide binding]; other site 234621016560 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 234621016561 Helix-turn-helix domain; Region: HTH_18; pfam12833 234621016562 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 234621016563 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 234621016564 catalytic residues [active] 234621016565 Transcriptional regulators [Transcription]; Region: MarR; COG1846 234621016566 MarR family; Region: MarR_2; pfam12802 234621016567 MarR family; Region: MarR; pfam01047 234621016568 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621016569 Major Facilitator Superfamily; Region: MFS_1; pfam07690 234621016570 putative substrate translocation pore; other site 234621016571 Uncharacterized conserved protein [Function unknown]; Region: COG1434 234621016572 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 234621016573 putative active site [active] 234621016574 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 234621016575 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 234621016576 active site 234621016577 catalytic triad [active] 234621016578 oxyanion hole [active] 234621016579 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621016580 Major Facilitator Superfamily; Region: MFS_1; pfam07690 234621016581 putative substrate translocation pore; other site 234621016582 Secretory lipase; Region: LIP; pfam03583 234621016583 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 234621016584 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 234621016585 putative Iron-sulfur protein interface [polypeptide binding]; other site 234621016586 proximal heme binding site [chemical binding]; other site 234621016587 distal heme binding site [chemical binding]; other site 234621016588 putative dimer interface [polypeptide binding]; other site 234621016589 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 234621016590 L-aspartate oxidase; Provisional; Region: PRK06175 234621016591 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 234621016592 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 234621016593 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 234621016594 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 234621016595 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 234621016596 transmembrane helices; other site 234621016597 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 234621016598 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 234621016599 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 234621016600 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 234621016601 Catalytic site [active] 234621016602 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238 234621016603 dimer interface [polypeptide binding]; other site 234621016604 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234621016605 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 234621016606 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621016607 NAD(P) binding site [chemical binding]; other site 234621016608 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621016609 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621016610 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 234621016611 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 234621016612 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 234621016613 dimer interface [polypeptide binding]; other site 234621016614 active site 234621016615 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 234621016616 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 234621016617 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 234621016618 Predicted transcriptional regulator [Transcription]; Region: COG1959 234621016619 Transcriptional regulator; Region: Rrf2; cl17282 234621016620 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 234621016621 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 234621016622 heme-binding site [chemical binding]; other site 234621016623 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 234621016624 FAD binding pocket [chemical binding]; other site 234621016625 FAD binding motif [chemical binding]; other site 234621016626 phosphate binding motif [ion binding]; other site 234621016627 beta-alpha-beta structure motif; other site 234621016628 NAD binding pocket [chemical binding]; other site 234621016629 Heme binding pocket [chemical binding]; other site 234621016630 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 234621016631 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621016632 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 234621016633 acyl-activating enzyme (AAE) consensus motif; other site 234621016634 AMP binding site [chemical binding]; other site 234621016635 active site 234621016636 CoA binding site [chemical binding]; other site 234621016637 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 234621016638 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 234621016639 FAD binding pocket [chemical binding]; other site 234621016640 FAD binding motif [chemical binding]; other site 234621016641 phosphate binding motif [ion binding]; other site 234621016642 beta-alpha-beta structure motif; other site 234621016643 NAD(p) ribose binding residues [chemical binding]; other site 234621016644 NAD binding pocket [chemical binding]; other site 234621016645 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 234621016646 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 234621016647 catalytic loop [active] 234621016648 iron binding site [ion binding]; other site 234621016649 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 234621016650 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 234621016651 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 234621016652 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 234621016653 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 234621016654 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 234621016655 enoyl-CoA hydratase; Region: PLN02600 234621016656 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 234621016657 substrate binding site [chemical binding]; other site 234621016658 oxyanion hole (OAH) forming residues; other site 234621016659 trimer interface [polypeptide binding]; other site 234621016660 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 234621016661 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 234621016662 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 234621016663 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 234621016664 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 234621016665 substrate binding site [chemical binding]; other site 234621016666 oxyanion hole (OAH) forming residues; other site 234621016667 trimer interface [polypeptide binding]; other site 234621016668 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621016669 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621016670 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 234621016671 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 234621016672 substrate binding site [chemical binding]; other site 234621016673 dimer interface [polypeptide binding]; other site 234621016674 NADP binding site [chemical binding]; other site 234621016675 catalytic residues [active] 234621016676 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 234621016677 active site 2 [active] 234621016678 active site 1 [active] 234621016679 EthD domain; Region: EthD; cl17553 234621016680 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 234621016681 CoenzymeA binding site [chemical binding]; other site 234621016682 subunit interaction site [polypeptide binding]; other site 234621016683 PHB binding site; other site 234621016684 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 234621016685 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 234621016686 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 234621016687 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 234621016688 Predicted membrane protein (DUF2127); Region: DUF2127; cl01785 234621016689 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 234621016690 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 234621016691 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 234621016692 inhibitor-cofactor binding pocket; inhibition site 234621016693 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234621016694 catalytic residue [active] 234621016695 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 234621016696 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 234621016697 NAD(P) binding site [chemical binding]; other site 234621016698 catalytic residues [active] 234621016699 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 234621016700 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 234621016701 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 234621016702 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 234621016703 Spore germination protein; Region: Spore_permease; cl17796 234621016704 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 234621016705 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 234621016706 metal binding site [ion binding]; metal-binding site 234621016707 active site 234621016708 I-site; other site 234621016709 PAS fold; Region: PAS_4; pfam08448 234621016710 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 234621016711 putative active site [active] 234621016712 heme pocket [chemical binding]; other site 234621016713 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 234621016714 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 234621016715 metal binding site [ion binding]; metal-binding site 234621016716 active site 234621016717 I-site; other site 234621016718 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 234621016719 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 234621016720 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621016721 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 234621016722 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 234621016723 metal ion-dependent adhesion site (MIDAS); other site 234621016724 MoxR-like ATPases [General function prediction only]; Region: COG0714 234621016725 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 234621016726 SWIM zinc finger; Region: SWIM; pfam04434 234621016727 Domain of unknown function (DUF222); Region: DUF222; pfam02720 234621016728 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 234621016729 active site 234621016730 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 234621016731 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 234621016732 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 234621016733 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 234621016734 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 234621016735 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 234621016736 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621016737 acyl-activating enzyme (AAE) consensus motif; other site 234621016738 AMP binding site [chemical binding]; other site 234621016739 active site 234621016740 CoA binding site [chemical binding]; other site 234621016741 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 234621016742 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 234621016743 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 234621016744 dimerization interface [polypeptide binding]; other site 234621016745 Lysine efflux permease [General function prediction only]; Region: COG1279 234621016746 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 234621016747 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 234621016748 Cl- selectivity filter; other site 234621016749 Cl- binding residues [ion binding]; other site 234621016750 pore gating glutamate residue; other site 234621016751 dimer interface [polypeptide binding]; other site 234621016752 H+/Cl- coupling transport residue; other site 234621016753 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 234621016754 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 234621016755 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 234621016756 Transcriptional regulator [Transcription]; Region: IclR; COG1414 234621016757 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 234621016758 Bacterial transcriptional regulator; Region: IclR; pfam01614 234621016759 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 234621016760 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 234621016761 Transcriptional regulator [Transcription]; Region: LysR; COG0583 234621016762 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 234621016763 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 234621016764 dimerization interface [polypeptide binding]; other site 234621016765 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 234621016766 NAD-dependent benzaldehyde dehydrogenase II-like; Region: ALDH_BenzADH; cd07152 234621016767 NAD(P) binding site [chemical binding]; other site 234621016768 catalytic residues [active] 234621016769 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621016770 putative substrate translocation pore; other site 234621016771 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621016772 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 234621016773 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 234621016774 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 234621016775 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234621016776 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 234621016777 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 234621016778 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 234621016779 short chain dehydrogenase; Provisional; Region: PRK07825 234621016780 classical (c) SDRs; Region: SDR_c; cd05233 234621016781 NAD(P) binding site [chemical binding]; other site 234621016782 active site 234621016783 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 234621016784 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 234621016785 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 234621016786 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 234621016787 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 234621016788 AMP-binding domain protein; Validated; Region: PRK08315 234621016789 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621016790 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 234621016791 acyl-activating enzyme (AAE) consensus motif; other site 234621016792 acyl-activating enzyme (AAE) consensus motif; other site 234621016793 putative AMP binding site [chemical binding]; other site 234621016794 putative active site [active] 234621016795 putative CoA binding site [chemical binding]; other site 234621016796 enoyl-CoA hydratase; Provisional; Region: PRK12478 234621016797 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 234621016798 substrate binding site [chemical binding]; other site 234621016799 oxyanion hole (OAH) forming residues; other site 234621016800 trimer interface [polypeptide binding]; other site 234621016801 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621016802 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621016803 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 234621016804 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 234621016805 active site 234621016806 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 234621016807 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 234621016808 substrate binding pocket [chemical binding]; other site 234621016809 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 234621016810 ANTAR domain; Region: ANTAR; cl04297 234621016811 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621016812 metabolite-proton symporter; Region: 2A0106; TIGR00883 234621016813 putative substrate translocation pore; other site 234621016814 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 234621016815 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 234621016816 active site 234621016817 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 234621016818 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 234621016819 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 234621016820 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 234621016821 AsnC family; Region: AsnC_trans_reg; pfam01037 234621016822 Transcriptional regulators [Transcription]; Region: FadR; COG2186 234621016823 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 234621016824 DNA-binding site [nucleotide binding]; DNA binding site 234621016825 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 234621016826 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234621016827 S-adenosylmethionine binding site [chemical binding]; other site 234621016828 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 234621016829 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 234621016830 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 234621016831 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 234621016832 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 234621016833 Transcription factor WhiB; Region: Whib; pfam02467 234621016834 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 234621016835 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 234621016836 active site 234621016837 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 234621016838 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 234621016839 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 234621016840 catalytic residue [active] 234621016841 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 234621016842 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 234621016843 Patatin-like phospholipase; Region: Patatin; pfam01734 234621016844 dihydroxyacetone kinase; Provisional; Region: PRK14479 234621016845 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 234621016846 DAK2 domain; Region: Dak2; pfam02734 234621016847 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 234621016848 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 234621016849 dimer interface [polypeptide binding]; other site 234621016850 acyl-activating enzyme (AAE) consensus motif; other site 234621016851 putative active site [active] 234621016852 AMP binding site [chemical binding]; other site 234621016853 putative CoA binding site [chemical binding]; other site 234621016854 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621016855 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621016856 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621016857 NAD(P) binding site [chemical binding]; other site 234621016858 active site 234621016859 acetyl-CoA acetyltransferase; Provisional; Region: PRK06504 234621016860 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 234621016861 dimer interface [polypeptide binding]; other site 234621016862 active site 234621016863 Catalytic domain of Protein Kinases; Region: PKc; cd00180 234621016864 active site 234621016865 ATP binding site [chemical binding]; other site 234621016866 substrate binding site [chemical binding]; other site 234621016867 activation loop (A-loop); other site 234621016868 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 234621016869 active site 234621016870 zinc binding site [ion binding]; other site 234621016871 Domain of unknown function (DUF222); Region: DUF222; pfam02720 234621016872 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 234621016873 active site 234621016874 short chain dehydrogenase; Provisional; Region: PRK05866 234621016875 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621016876 NAD(P) binding site [chemical binding]; other site 234621016877 active site 234621016878 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 234621016879 Ferredoxin [Energy production and conversion]; Region: COG1146 234621016880 4Fe-4S binding domain; Region: Fer4; pfam00037 234621016881 ferredoxin-NADP+ reductase; Region: PLN02852 234621016882 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 234621016883 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 234621016884 DUF35 OB-fold domain; Region: DUF35; pfam01796 234621016885 lipid-transfer protein; Provisional; Region: PRK06059 234621016886 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 234621016887 active site 234621016888 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 234621016889 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 234621016890 Helix-turn-helix domain; Region: HTH_18; pfam12833 234621016891 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 234621016892 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 234621016893 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 234621016894 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 234621016895 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 234621016896 Transcriptional regulators [Transcription]; Region: FadR; COG2186 234621016897 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 234621016898 DNA-binding site [nucleotide binding]; DNA binding site 234621016899 FCD domain; Region: FCD; pfam07729 234621016900 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 234621016901 Aspartase; Region: Aspartase; cd01357 234621016902 active sites [active] 234621016903 tetramer interface [polypeptide binding]; other site 234621016904 L-asparagine permease; Provisional; Region: PRK15049 234621016905 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 234621016906 active site 234621016907 homotetramer interface [polypeptide binding]; other site 234621016908 homodimer interface [polypeptide binding]; other site 234621016909 AAA ATPase domain; Region: AAA_16; pfam13191 234621016910 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 234621016911 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 234621016912 DNA binding residues [nucleotide binding] 234621016913 dimerization interface [polypeptide binding]; other site 234621016914 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 234621016915 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 234621016916 Sulfate transporter family; Region: Sulfate_transp; pfam00916 234621016917 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 234621016918 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 234621016919 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 234621016920 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 234621016921 putative hydrophobic ligand binding site [chemical binding]; other site 234621016922 Cation efflux family; Region: Cation_efflux; cl00316 234621016923 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 234621016924 dimerization interface [polypeptide binding]; other site 234621016925 putative DNA binding site [nucleotide binding]; other site 234621016926 putative Zn2+ binding site [ion binding]; other site 234621016927 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 234621016928 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 234621016929 active site 1 [active] 234621016930 active site 2 [active] 234621016931 CHAP domain; Region: CHAP; cl17642 234621016932 HicB family; Region: HicB; pfam05534 234621016933 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 234621016934 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234621016935 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 234621016936 Walker A/P-loop; other site 234621016937 ATP binding site [chemical binding]; other site 234621016938 Q-loop/lid; other site 234621016939 ABC transporter signature motif; other site 234621016940 Walker B; other site 234621016941 D-loop; other site 234621016942 H-loop/switch region; other site 234621016943 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 234621016944 ABC-2 type transporter; Region: ABC2_membrane; cl17235 234621016945 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 234621016946 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 234621016947 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 234621016948 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 234621016949 intersubunit interface [polypeptide binding]; other site 234621016950 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621016951 putative substrate translocation pore; other site 234621016952 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 234621016953 putative catalytic site [active] 234621016954 putative phosphate binding site [ion binding]; other site 234621016955 putative metal binding site [ion binding]; other site 234621016956 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 234621016957 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621016958 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621016959 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 234621016960 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621016961 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621016962 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293 234621016963 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 234621016964 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 234621016965 Putative ParB-like nuclease; Region: ParBc_2; cl17538 234621016966 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 234621016967 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 234621016968 active site 234621016969 dimer interface [polypeptide binding]; other site 234621016970 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 234621016971 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 234621016972 active site 234621016973 FMN binding site [chemical binding]; other site 234621016974 substrate binding site [chemical binding]; other site 234621016975 3Fe-4S cluster binding site [ion binding]; other site 234621016976 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 234621016977 domain_subunit interface; other site 234621016978 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 234621016979 Flavodoxin; Region: Flavodoxin_1; pfam00258 234621016980 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 234621016981 FAD binding pocket [chemical binding]; other site 234621016982 FAD binding motif [chemical binding]; other site 234621016983 catalytic residues [active] 234621016984 NAD binding pocket [chemical binding]; other site 234621016985 phosphate binding motif [ion binding]; other site 234621016986 beta-alpha-beta structure motif; other site 234621016987 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 234621016988 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 234621016989 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 234621016990 Walker A/P-loop; other site 234621016991 ATP binding site [chemical binding]; other site 234621016992 Q-loop/lid; other site 234621016993 ABC transporter signature motif; other site 234621016994 Walker B; other site 234621016995 D-loop; other site 234621016996 H-loop/switch region; other site 234621016997 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 234621016998 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 234621016999 Walker A/P-loop; other site 234621017000 ATP binding site [chemical binding]; other site 234621017001 Q-loop/lid; other site 234621017002 ABC transporter signature motif; other site 234621017003 Walker B; other site 234621017004 D-loop; other site 234621017005 H-loop/switch region; other site 234621017006 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 234621017007 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 234621017008 intersubunit interface [polypeptide binding]; other site 234621017009 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 234621017010 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 234621017011 FAD binding pocket [chemical binding]; other site 234621017012 FAD binding motif [chemical binding]; other site 234621017013 phosphate binding motif [ion binding]; other site 234621017014 NAD binding pocket [chemical binding]; other site 234621017015 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 234621017016 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 234621017017 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 234621017018 Helix-turn-helix domain; Region: HTH_18; pfam12833 234621017019 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621017020 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621017021 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 234621017022 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 234621017023 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 234621017024 Beta-lactamase; Region: Beta-lactamase; pfam00144 234621017025 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 234621017026 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 234621017027 NAD binding site [chemical binding]; other site 234621017028 substrate binding site [chemical binding]; other site 234621017029 catalytic Zn binding site [ion binding]; other site 234621017030 structural Zn binding site [ion binding]; other site 234621017031 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 234621017032 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621017033 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 234621017034 acyl-activating enzyme (AAE) consensus motif; other site 234621017035 acyl-activating enzyme (AAE) consensus motif; other site 234621017036 putative AMP binding site [chemical binding]; other site 234621017037 putative active site [active] 234621017038 putative CoA binding site [chemical binding]; other site 234621017039 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 234621017040 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234621017041 active site 234621017042 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 234621017043 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 234621017044 classical (c) SDRs; Region: SDR_c; cd05233 234621017045 NAD(P) binding site [chemical binding]; other site 234621017046 active site 234621017047 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 234621017048 Uncharacterized conserved protein [Function unknown]; Region: COG2128 234621017049 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 234621017050 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 234621017051 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 234621017052 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 234621017053 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 234621017054 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 234621017055 active site 234621017056 catalytic residues [active] 234621017057 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 234621017058 putative ADP-ribose binding site [chemical binding]; other site 234621017059 putative active site [active] 234621017060 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 234621017061 Phosphoesterase family; Region: Phosphoesterase; pfam04185 234621017062 Domain of unknown function (DUF756); Region: DUF756; pfam05506 234621017063 Domain of unknown function (DUF756); Region: DUF756; pfam05506 234621017064 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 234621017065 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 234621017066 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 234621017067 substrate binding pocket [chemical binding]; other site 234621017068 Predicted transcriptional regulators [Transcription]; Region: COG1733 234621017069 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 234621017070 dimerization interface [polypeptide binding]; other site 234621017071 putative DNA binding site [nucleotide binding]; other site 234621017072 putative Zn2+ binding site [ion binding]; other site 234621017073 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621017074 NAD(P) binding site [chemical binding]; other site 234621017075 active site 234621017076 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621017077 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621017078 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 234621017079 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 234621017080 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 234621017081 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 234621017082 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 234621017083 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 234621017084 iron-sulfur cluster [ion binding]; other site 234621017085 [2Fe-2S] cluster binding site [ion binding]; other site 234621017086 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 234621017087 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 234621017088 intersubunit interface [polypeptide binding]; other site 234621017089 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 234621017090 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 234621017091 DNA binding site [nucleotide binding] 234621017092 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 234621017093 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 234621017094 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 234621017095 substrate binding pocket [chemical binding]; other site 234621017096 catalytic triad [active] 234621017097 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 234621017098 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 234621017099 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621017100 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621017101 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 234621017102 Amidase; Region: Amidase; cl11426 234621017103 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621017104 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621017105 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 234621017106 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 234621017107 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 234621017108 Domain of unknown function (DUF222); Region: DUF222; pfam02720 234621017109 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 234621017110 active site 234621017111 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 234621017112 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 234621017113 potential catalytic triad [active] 234621017114 conserved cys residue [active] 234621017115 Secretory lipase; Region: LIP; pfam03583 234621017116 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621017117 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621017118 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 234621017119 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234621017120 DNA binding residues [nucleotide binding] 234621017121 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 234621017122 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 234621017123 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 234621017124 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 234621017125 Transcriptional regulator [Transcription]; Region: LysR; COG0583 234621017126 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 234621017127 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 234621017128 dimerization interface [polypeptide binding]; other site 234621017129 substrate binding pocket [chemical binding]; other site 234621017130 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 234621017131 FAD binding domain; Region: FAD_binding_4; pfam01565 234621017132 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 234621017133 catalytic core [active] 234621017134 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 234621017135 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 234621017136 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 234621017137 NAD(P) binding site [chemical binding]; other site 234621017138 catalytic residues [active] 234621017139 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 234621017140 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621017141 NAD(P) binding site [chemical binding]; other site 234621017142 active site 234621017143 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621017144 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621017145 Secretory lipase; Region: LIP; pfam03583 234621017146 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 234621017147 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 234621017148 FAD binding pocket [chemical binding]; other site 234621017149 FAD binding motif [chemical binding]; other site 234621017150 phosphate binding motif [ion binding]; other site 234621017151 NAD binding pocket [chemical binding]; other site 234621017152 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 234621017153 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 234621017154 Walker A/P-loop; other site 234621017155 ATP binding site [chemical binding]; other site 234621017156 Q-loop/lid; other site 234621017157 ABC transporter signature motif; other site 234621017158 Walker B; other site 234621017159 D-loop; other site 234621017160 H-loop/switch region; other site 234621017161 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 234621017162 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 234621017163 ABC-ATPase subunit interface; other site 234621017164 dimer interface [polypeptide binding]; other site 234621017165 putative PBP binding regions; other site 234621017166 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 234621017167 FecCD transport family; Region: FecCD; pfam01032 234621017168 ABC-ATPase subunit interface; other site 234621017169 dimer interface [polypeptide binding]; other site 234621017170 putative PBP binding regions; other site 234621017171 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 234621017172 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 234621017173 siderophore binding site; other site 234621017174 Cupin domain; Region: Cupin_2; cl17218 234621017175 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 234621017176 DNA binding residues [nucleotide binding] 234621017177 Helix-turn-helix domain; Region: HTH_18; pfam12833 234621017178 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 234621017179 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 234621017180 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 234621017181 putative dimer interface [polypeptide binding]; other site 234621017182 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 234621017183 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621017184 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 234621017185 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971 234621017186 active site 234621017187 acyl-activating enzyme (AAE) consensus motif; other site 234621017188 putative CoA binding site [chemical binding]; other site 234621017189 AMP binding site [chemical binding]; other site 234621017190 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 234621017191 active site 2 [active] 234621017192 active site 1 [active] 234621017193 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621017194 metabolite-proton symporter; Region: 2A0106; TIGR00883 234621017195 putative substrate translocation pore; other site 234621017196 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621017197 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621017198 Competence-damaged protein; Region: CinA; pfam02464 234621017199 carboxylate-amine ligase; Provisional; Region: PRK13517 234621017200 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 234621017201 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 234621017202 hydroperoxidase II; Provisional; Region: katE; PRK11249 234621017203 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 234621017204 heme binding pocket [chemical binding]; other site 234621017205 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 234621017206 domain interactions; other site 234621017207 CsbD-like; Region: CsbD; pfam05532 234621017208 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 234621017209 Part of AAA domain; Region: AAA_19; pfam13245 234621017210 Family description; Region: UvrD_C_2; pfam13538 234621017211 Transcriptional regulator [Transcription]; Region: IclR; COG1414 234621017212 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 234621017213 Bacterial transcriptional regulator; Region: IclR; pfam01614 234621017214 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 234621017215 acetaldehyde dehydrogenase; Validated; Region: PRK08300 234621017216 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 234621017217 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 234621017218 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 234621017219 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 234621017220 active site 234621017221 catalytic residues [active] 234621017222 metal binding site [ion binding]; metal-binding site 234621017223 DmpG-like communication domain; Region: DmpG_comm; pfam07836 234621017224 Protein of unknown function (DUF664); Region: DUF664; pfam04978 234621017225 DinB superfamily; Region: DinB_2; pfam12867 234621017226 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 234621017227 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 234621017228 DNA binding residues [nucleotide binding] 234621017229 putative dimer interface [polypeptide binding]; other site 234621017230 HEAT repeats; Region: HEAT_2; pfam13646 234621017231 HEAT repeats; Region: HEAT_2; pfam13646 234621017232 HEAT repeats; Region: HEAT_2; pfam13646 234621017233 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 234621017234 conserved cys residue [active] 234621017235 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 234621017236 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 234621017237 conserved cys residue [active] 234621017238 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 234621017239 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 234621017240 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 234621017241 A new structural DNA glycosylase; Region: AlkD_like; cd06561 234621017242 active site 234621017243 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 234621017244 classical (c) SDRs; Region: SDR_c; cd05233 234621017245 NAD(P) binding site [chemical binding]; other site 234621017246 active site 234621017247 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 234621017248 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621017249 short chain dehydrogenase; Validated; Region: PRK08264 234621017250 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621017251 NAD(P) binding site [chemical binding]; other site 234621017252 active site 234621017253 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 234621017254 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 234621017255 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 234621017256 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 234621017257 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621017258 putative substrate translocation pore; other site 234621017259 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234621017260 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 234621017261 salt bridge; other site 234621017262 non-specific DNA binding site [nucleotide binding]; other site 234621017263 sequence-specific DNA binding site [nucleotide binding]; other site 234621017264 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 234621017265 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 234621017266 catalytic Zn binding site [ion binding]; other site 234621017267 NAD(P) binding site [chemical binding]; other site 234621017268 structural Zn binding site [ion binding]; other site 234621017269 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 234621017270 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 234621017271 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621017272 active site 234621017273 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 234621017274 Nitronate monooxygenase; Region: NMO; pfam03060 234621017275 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 234621017276 FMN binding site [chemical binding]; other site 234621017277 substrate binding site [chemical binding]; other site 234621017278 putative catalytic residue [active] 234621017279 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 234621017280 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621017281 putative substrate translocation pore; other site 234621017282 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 234621017283 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865 234621017284 putative hydrophobic ligand binding site [chemical binding]; other site 234621017285 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 234621017286 S-adenosylmethionine binding site [chemical binding]; other site 234621017287 Protein of unknown function (DUF3253); Region: DUF3253; pfam11625 234621017288 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 234621017289 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621017290 NAD(P) binding site [chemical binding]; other site 234621017291 active site 234621017292 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 234621017293 MarR family; Region: MarR; pfam01047 234621017294 amidase; Provisional; Region: PRK07486 234621017295 Amidase; Region: Amidase; cl11426 234621017296 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 234621017297 Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777 234621017298 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 234621017299 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 234621017300 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 234621017301 CoA-transferase family III; Region: CoA_transf_3; pfam02515 234621017302 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621017303 metabolite-proton symporter; Region: 2A0106; TIGR00883 234621017304 putative substrate translocation pore; other site 234621017305 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 234621017306 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 234621017307 metal binding site [ion binding]; metal-binding site 234621017308 dimer interface [polypeptide binding]; other site 234621017309 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 234621017310 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 234621017311 AsnC family; Region: AsnC_trans_reg; pfam01037 234621017312 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 234621017313 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 234621017314 AsnC family; Region: AsnC_trans_reg; pfam01037 234621017315 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621017316 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621017317 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 234621017318 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 234621017319 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 234621017320 catalytic residue [active] 234621017321 Predicted membrane protein [Function unknown]; Region: COG2149 234621017322 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 234621017323 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 234621017324 metal ion-dependent adhesion site (MIDAS); other site 234621017325 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 234621017326 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 234621017327 Walker A motif; other site 234621017328 ATP binding site [chemical binding]; other site 234621017329 Walker B motif; other site 234621017330 arginine finger; other site 234621017331 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 234621017332 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 234621017333 Amidase; Region: Amidase; cl11426 234621017334 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 234621017335 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621017336 putative substrate translocation pore; other site 234621017337 Transcriptional regulator [Transcription]; Region: LysR; COG0583 234621017338 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 234621017339 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 234621017340 dimerization interface [polypeptide binding]; other site 234621017341 substrate binding pocket [chemical binding]; other site 234621017342 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 234621017343 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 234621017344 catalytic site [active] 234621017345 Transcriptional regulator [Transcription]; Region: LysR; COG0583 234621017346 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 234621017347 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 234621017348 dimerization interface [polypeptide binding]; other site 234621017349 Transcriptional regulator [Transcription]; Region: LysR; COG0583 234621017350 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 234621017351 putative DNA binding site [nucleotide binding]; other site 234621017352 putative Zn2+ binding site [ion binding]; other site 234621017353 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 234621017354 dimerization interface [polypeptide binding]; other site 234621017355 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 234621017356 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234621017357 dimer interface [polypeptide binding]; other site 234621017358 conserved gate region; other site 234621017359 putative PBP binding loops; other site 234621017360 ABC-ATPase subunit interface; other site 234621017361 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 234621017362 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 234621017363 Walker A/P-loop; other site 234621017364 ATP binding site [chemical binding]; other site 234621017365 Q-loop/lid; other site 234621017366 ABC transporter signature motif; other site 234621017367 Walker B; other site 234621017368 D-loop; other site 234621017369 H-loop/switch region; other site 234621017370 NMT1/THI5 like; Region: NMT1; pfam09084 234621017371 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 234621017372 substrate binding pocket [chemical binding]; other site 234621017373 membrane-bound complex binding site; other site 234621017374 hinge residues; other site 234621017375 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 234621017376 CoA-transferase family III; Region: CoA_transf_3; pfam02515 234621017377 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 234621017378 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 234621017379 FMN binding site [chemical binding]; other site 234621017380 substrate binding site [chemical binding]; other site 234621017381 putative catalytic residue [active] 234621017382 AAA domain; Region: AAA_17; pfam13207 234621017383 replicative DNA helicase; Provisional; Region: PRK05636 234621017384 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 234621017385 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 234621017386 Walker A motif; other site 234621017387 ATP binding site [chemical binding]; other site 234621017388 Walker B motif; other site 234621017389 DNA binding loops [nucleotide binding] 234621017390 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 234621017391 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 234621017392 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 234621017393 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 234621017394 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 234621017395 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 234621017396 dimer interface [polypeptide binding]; other site 234621017397 ssDNA binding site [nucleotide binding]; other site 234621017398 tetramer (dimer of dimers) interface [polypeptide binding]; other site 234621017399 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 234621017400 Predicted integral membrane protein [Function unknown]; Region: COG5650 234621017401 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 234621017402 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 234621017403 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 234621017404 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234621017405 non-specific DNA binding site [nucleotide binding]; other site 234621017406 salt bridge; other site 234621017407 sequence-specific DNA binding site [nucleotide binding]; other site 234621017408 AAA ATPase domain; Region: AAA_16; pfam13191 234621017409 FOG: WD40 repeat [General function prediction only]; Region: COG2319 234621017410 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 234621017411 structural tetrad; other site 234621017412 FOG: WD40 repeat [General function prediction only]; Region: COG2319 234621017413 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 234621017414 structural tetrad; other site 234621017415 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 234621017416 DNA binding residues [nucleotide binding] 234621017417 Predicted integral membrane protein [Function unknown]; Region: COG5650 234621017418 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 234621017419 Transglycosylase; Region: Transgly; pfam00912 234621017420 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 234621017421 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 234621017422 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 234621017423 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 234621017424 Predicted transcriptional regulators [Transcription]; Region: COG1695 234621017425 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 234621017426 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 234621017427 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 234621017428 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 234621017429 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 234621017430 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 234621017431 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 234621017432 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 234621017433 active site 234621017434 FMN binding site [chemical binding]; other site 234621017435 substrate binding site [chemical binding]; other site 234621017436 putative catalytic residue [active] 234621017437 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 234621017438 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 234621017439 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 234621017440 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 234621017441 DNA-binding site [nucleotide binding]; DNA binding site 234621017442 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 234621017443 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234621017444 homodimer interface [polypeptide binding]; other site 234621017445 catalytic residue [active] 234621017446 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 234621017447 Domain of unknown function (DUF222); Region: DUF222; pfam02720 234621017448 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 234621017449 active site 234621017450 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 234621017451 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 234621017452 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 234621017453 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 234621017454 Transcriptional regulator [Transcription]; Region: IclR; COG1414 234621017455 Bacterial transcriptional regulator; Region: IclR; pfam01614 234621017456 NMT1/THI5 like; Region: NMT1; pfam09084 234621017457 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 234621017458 substrate binding pocket [chemical binding]; other site 234621017459 membrane-bound complex binding site; other site 234621017460 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 234621017461 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234621017462 dimer interface [polypeptide binding]; other site 234621017463 conserved gate region; other site 234621017464 putative PBP binding loops; other site 234621017465 ABC-ATPase subunit interface; other site 234621017466 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 234621017467 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 234621017468 Walker A/P-loop; other site 234621017469 ATP binding site [chemical binding]; other site 234621017470 Q-loop/lid; other site 234621017471 ABC transporter signature motif; other site 234621017472 Walker B; other site 234621017473 D-loop; other site 234621017474 H-loop/switch region; other site 234621017475 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 234621017476 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 234621017477 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 234621017478 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 234621017479 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 234621017480 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 234621017481 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 234621017482 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 234621017483 substrate binding pocket [chemical binding]; other site 234621017484 membrane-bound complex binding site; other site 234621017485 hinge residues; other site 234621017486 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 234621017487 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 234621017488 putative active site [active] 234621017489 putative NTP binding site [chemical binding]; other site 234621017490 putative nucleic acid binding site [nucleotide binding]; other site 234621017491 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 234621017492 homotrimer interaction site [polypeptide binding]; other site 234621017493 putative active site [active] 234621017494 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 234621017495 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 234621017496 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 234621017497 Transcriptional regulator [Transcription]; Region: IclR; COG1414 234621017498 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 234621017499 NMT1/THI5 like; Region: NMT1; pfam09084 234621017500 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 234621017501 substrate binding pocket [chemical binding]; other site 234621017502 membrane-bound complex binding site; other site 234621017503 hinge residues; other site 234621017504 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 234621017505 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234621017506 dimer interface [polypeptide binding]; other site 234621017507 conserved gate region; other site 234621017508 putative PBP binding loops; other site 234621017509 ABC-ATPase subunit interface; other site 234621017510 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 234621017511 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234621017512 dimer interface [polypeptide binding]; other site 234621017513 conserved gate region; other site 234621017514 ABC-ATPase subunit interface; other site 234621017515 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 234621017516 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 234621017517 Walker A/P-loop; other site 234621017518 ATP binding site [chemical binding]; other site 234621017519 Q-loop/lid; other site 234621017520 ABC transporter signature motif; other site 234621017521 Walker B; other site 234621017522 D-loop; other site 234621017523 H-loop/switch region; other site 234621017524 Uncharacterized conserved protein [Function unknown]; Region: COG1434 234621017525 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 234621017526 putative active site [active] 234621017527 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 234621017528 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621017529 NAD(P) binding site [chemical binding]; other site 234621017530 active site 234621017531 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 234621017532 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 234621017533 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 234621017534 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 234621017535 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 234621017536 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 234621017537 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 234621017538 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 234621017539 putative hydrophobic ligand binding site [chemical binding]; other site 234621017540 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 234621017541 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 234621017542 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 234621017543 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 234621017544 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 234621017545 catalytic loop [active] 234621017546 iron binding site [ion binding]; other site 234621017547 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 234621017548 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 234621017549 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 234621017550 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 234621017551 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 234621017552 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 234621017553 inhibitor-cofactor binding pocket; inhibition site 234621017554 pyridoxal 5'-phosphate binding site [chemical binding]; other site 234621017555 catalytic residue [active] 234621017556 amidase; Provisional; Region: PRK07486 234621017557 Amidase; Region: Amidase; cl11426 234621017558 Amidohydrolase ring-opening protein (Amido_AtzD_TrzD); Region: Amido_AtzD_TrzD; cl17559 234621017559 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 234621017560 active site 234621017561 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 234621017562 DRTGG domain; Region: DRTGG; pfam07085 234621017563 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 234621017564 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 234621017565 CoA-transferase family III; Region: CoA_transf_3; pfam02515 234621017566 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 234621017567 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 234621017568 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 234621017569 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 234621017570 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 234621017571 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 234621017572 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 234621017573 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 234621017574 XdhC Rossmann domain; Region: XdhC_C; pfam13478 234621017575 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 234621017576 CoA-transferase family III; Region: CoA_transf_3; pfam02515 234621017577 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621017578 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621017579 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 234621017580 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 234621017581 substrate binding site [chemical binding]; other site 234621017582 oxyanion hole (OAH) forming residues; other site 234621017583 trimer interface [polypeptide binding]; other site 234621017584 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 234621017585 AAA domain; Region: AAA_18; pfam13238 234621017586 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 234621017587 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 234621017588 Amidase; Region: Amidase; cl11426 234621017589 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 234621017590 dimerization interface [polypeptide binding]; other site 234621017591 putative DNA binding site [nucleotide binding]; other site 234621017592 putative Zn2+ binding site [ion binding]; other site 234621017593 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 234621017594 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 234621017595 NAD(P) binding site [chemical binding]; other site 234621017596 active site 234621017597 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 234621017598 Transglycosylase; Region: Transgly; pfam00912 234621017599 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 234621017600 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 234621017601 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234621017602 dimer interface [polypeptide binding]; other site 234621017603 conserved gate region; other site 234621017604 putative PBP binding loops; other site 234621017605 ABC-ATPase subunit interface; other site 234621017606 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 234621017607 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234621017608 dimer interface [polypeptide binding]; other site 234621017609 conserved gate region; other site 234621017610 putative PBP binding loops; other site 234621017611 ABC-ATPase subunit interface; other site 234621017612 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 234621017613 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 234621017614 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 234621017615 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 234621017616 Walker A/P-loop; other site 234621017617 ATP binding site [chemical binding]; other site 234621017618 Q-loop/lid; other site 234621017619 ABC transporter signature motif; other site 234621017620 Walker B; other site 234621017621 D-loop; other site 234621017622 H-loop/switch region; other site 234621017623 TOBE domain; Region: TOBE_2; pfam08402 234621017624 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 234621017625 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 234621017626 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 234621017627 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 234621017628 non-specific DNA binding site [nucleotide binding]; other site 234621017629 salt bridge; other site 234621017630 sequence-specific DNA binding site [nucleotide binding]; other site 234621017631 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 234621017632 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 234621017633 oligomer interface [polypeptide binding]; other site 234621017634 active site residues [active] 234621017635 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 234621017636 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 234621017637 oligomer interface [polypeptide binding]; other site 234621017638 active site residues [active] 234621017639 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 234621017640 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 234621017641 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 234621017642 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 234621017643 CoA-transferase family III; Region: CoA_transf_3; pfam02515 234621017644 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621017645 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 234621017646 active site 234621017647 metabolite-proton symporter; Region: 2A0106; TIGR00883 234621017648 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621017649 putative substrate translocation pore; other site 234621017650 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 234621017651 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 234621017652 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 234621017653 dimerization interface [polypeptide binding]; other site 234621017654 substrate binding pocket [chemical binding]; other site 234621017655 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 234621017656 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621017657 active site 234621017658 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 234621017659 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621017660 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 234621017661 acyl-activating enzyme (AAE) consensus motif; other site 234621017662 acyl-activating enzyme (AAE) consensus motif; other site 234621017663 putative AMP binding site [chemical binding]; other site 234621017664 putative active site [active] 234621017665 putative CoA binding site [chemical binding]; other site 234621017666 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621017667 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621017668 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 234621017669 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 234621017670 Haem-containing dehydratase; Region: Dehydratase_hem; pfam13816 234621017671 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 234621017672 dimerization interface [polypeptide binding]; other site 234621017673 putative DNA binding site [nucleotide binding]; other site 234621017674 putative Zn2+ binding site [ion binding]; other site 234621017675 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 234621017676 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 234621017677 amidase; Provisional; Region: PRK07235 234621017678 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 234621017679 nitrile hydratase, alpha subunit; Region: nitrile_alph; TIGR01323 234621017680 putative TOMM peptide; Region: TOMM_nitrile_2; TIGR04351 234621017681 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 234621017682 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 234621017683 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 234621017684 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 234621017685 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 234621017686 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 234621017687 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 234621017688 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 234621017689 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 234621017690 substrate binding pocket [chemical binding]; other site 234621017691 membrane-bound complex binding site; other site 234621017692 hinge residues; other site 234621017693 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 234621017694 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234621017695 dimer interface [polypeptide binding]; other site 234621017696 conserved gate region; other site 234621017697 putative PBP binding loops; other site 234621017698 ABC-ATPase subunit interface; other site 234621017699 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 234621017700 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 234621017701 Walker A/P-loop; other site 234621017702 ATP binding site [chemical binding]; other site 234621017703 Q-loop/lid; other site 234621017704 ABC transporter signature motif; other site 234621017705 Walker B; other site 234621017706 D-loop; other site 234621017707 H-loop/switch region; other site 234621017708 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 234621017709 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 234621017710 2-hydroxymuconic semialdehyde dehydrogenase; Region: OH_muco_semi_DH; TIGR03216 234621017711 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 234621017712 NAD binding site [chemical binding]; other site 234621017713 catalytic residues [active] 234621017714 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 234621017715 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 234621017716 homotrimer interaction site [polypeptide binding]; other site 234621017717 putative active site [active] 234621017718 3-hydroxyanthranilate 3,4-dioxygenase; Provisional; Region: PRK13264 234621017719 Amidohydrolase; Region: Amidohydro_2; pfam04909 234621017720 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 234621017721 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 234621017722 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 234621017723 dimerization interface [polypeptide binding]; other site 234621017724 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 234621017725 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 234621017726 putative NAD(P) binding site [chemical binding]; other site 234621017727 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 234621017728 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 234621017729 2-hydroxymuconic semialdehyde dehydrogenase; Region: OH_muco_semi_DH; TIGR03216 234621017730 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 234621017731 NAD(P) binding site [chemical binding]; other site 234621017732 catalytic residues [active] 234621017733 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 234621017734 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 234621017735 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 234621017736 acyl-activating enzyme (AAE) consensus motif; other site 234621017737 putative AMP binding site [chemical binding]; other site 234621017738 putative active site [active] 234621017739 putative CoA binding site [chemical binding]; other site 234621017740 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 234621017741 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 234621017742 thiolase; Provisional; Region: PRK06158 234621017743 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 234621017744 active site 234621017745 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 234621017746 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 234621017747 substrate binding pocket [chemical binding]; other site 234621017748 membrane-bound complex binding site; other site 234621017749 hinge residues; other site 234621017750 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 234621017751 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 234621017752 Walker A/P-loop; other site 234621017753 ATP binding site [chemical binding]; other site 234621017754 Q-loop/lid; other site 234621017755 ABC transporter signature motif; other site 234621017756 Walker B; other site 234621017757 D-loop; other site 234621017758 H-loop/switch region; other site 234621017759 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 234621017760 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 234621017761 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 234621017762 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 234621017763 dimer interface [polypeptide binding]; other site 234621017764 conserved gate region; other site 234621017765 putative PBP binding loops; other site 234621017766 ABC-ATPase subunit interface; other site 234621017767 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 234621017768 dimer interface [polypeptide binding]; other site 234621017769 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 234621017770 PYR/PP interface [polypeptide binding]; other site 234621017771 TPP binding site [chemical binding]; other site 234621017772 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 234621017773 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 234621017774 TPP-binding site [chemical binding]; other site 234621017775 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 234621017776 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 234621017777 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 234621017778 putative dimerization interface [polypeptide binding]; other site 234621017779 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 234621017780 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234621017781 YCII-related domain; Region: YCII; cl00999 234621017782 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 234621017783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 234621017784 active site 234621017785 phosphorylation site [posttranslational modification] 234621017786 intermolecular recognition site; other site 234621017787 dimerization interface [polypeptide binding]; other site 234621017788 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 234621017789 DNA binding residues [nucleotide binding] 234621017790 dimerization interface [polypeptide binding]; other site 234621017791 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 234621017792 Histidine kinase; Region: HisKA_3; pfam07730 234621017793 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 234621017794 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 234621017795 Walker A/P-loop; other site 234621017796 ATP binding site [chemical binding]; other site 234621017797 Q-loop/lid; other site 234621017798 ABC transporter signature motif; other site 234621017799 Walker B; other site 234621017800 D-loop; other site 234621017801 H-loop/switch region; other site 234621017802 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 234621017803 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 234621017804 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 234621017805 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 234621017806 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 234621017807 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 234621017808 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 234621017809 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 234621017810 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 234621017811 active site 234621017812 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 234621017813 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 234621017814 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 234621017815 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 234621017816 motif II; other site 234621017817 Cation efflux family; Region: Cation_efflux; cl00316 234621017818 Domain of unknown function (DUF222); Region: DUF222; pfam02720 234621017819 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 234621017820 active site 234621017821 hypothetical protein; Provisional; Region: PRK07945 234621017822 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 234621017823 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 234621017824 active site 234621017825 PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668 234621017826 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 234621017827 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 234621017828 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 234621017829 metal binding site [ion binding]; metal-binding site 234621017830 active site 234621017831 I-site; other site 234621017832 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 234621017833 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 234621017834 dimer interface [polypeptide binding]; other site 234621017835 putative PBP binding regions; other site 234621017836 ABC-ATPase subunit interface; other site 234621017837 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 234621017838 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 234621017839 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 234621017840 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 234621017841 metal binding site [ion binding]; metal-binding site 234621017842 short chain dehydrogenase; Provisional; Region: PRK08219 234621017843 classical (c) SDRs; Region: SDR_c; cd05233 234621017844 NAD(P) binding site [chemical binding]; other site 234621017845 active site 234621017846 TIGR04222 domain; Region: near_uncomplex 234621017847 TIGR04222 domain; Region: near_uncomplex 234621017848 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 234621017849 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 234621017850 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 234621017851 NAD binding site [chemical binding]; other site 234621017852 Phe binding site; other site 234621017853 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 234621017854 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 234621017855 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 234621017856 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 234621017857 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 234621017858 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 234621017859 E3 interaction surface; other site 234621017860 lipoyl attachment site [posttranslational modification]; other site 234621017861 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 234621017862 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 234621017863 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 234621017864 alpha subunit interface [polypeptide binding]; other site 234621017865 TPP binding site [chemical binding]; other site 234621017866 heterodimer interface [polypeptide binding]; other site 234621017867 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 234621017868 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 234621017869 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 234621017870 tetramer interface [polypeptide binding]; other site 234621017871 TPP-binding site [chemical binding]; other site 234621017872 heterodimer interface [polypeptide binding]; other site 234621017873 phosphorylation loop region [posttranslational modification] 234621017874 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 234621017875 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 234621017876 putative DNA binding site [nucleotide binding]; other site 234621017877 putative Zn2+ binding site [ion binding]; other site 234621017878 AsnC family; Region: AsnC_trans_reg; pfam01037 234621017879 hypothetical protein; Provisional; Region: PRK05409 234621017880 Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454 234621017881 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 234621017882 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 234621017883 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 234621017884 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 234621017885 catalytic site [active] 234621017886 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 234621017887 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 234621017888 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621017889 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 234621017890 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 234621017891 HIGH motif; other site 234621017892 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 234621017893 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 234621017894 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 234621017895 active site 234621017896 KMSKS motif; other site 234621017897 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 234621017898 tRNA binding surface [nucleotide binding]; other site 234621017899 anticodon binding site; other site 234621017900 SdpI/YhfL protein family; Region: SdpI; pfam13630 234621017901 Transcriptional regulators [Transcription]; Region: FadR; COG2186 234621017902 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 234621017903 DNA-binding site [nucleotide binding]; DNA binding site 234621017904 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 234621017905 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 234621017906 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 234621017907 hypothetical protein; Validated; Region: PRK00228 234621017908 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 234621017909 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 234621017910 NAD(P) binding site [chemical binding]; other site 234621017911 active site 234621017912 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621017913 Major Facilitator Superfamily; Region: MFS_1; pfam07690 234621017914 putative substrate translocation pore; other site 234621017915 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 234621017916 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621017917 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621017918 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621017919 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621017920 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 234621017921 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 234621017922 active site 234621017923 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 234621017924 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 234621017925 active site 234621017926 NTP binding site [chemical binding]; other site 234621017927 metal binding triad [ion binding]; metal-binding site 234621017928 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 234621017929 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 234621017930 Zn2+ binding site [ion binding]; other site 234621017931 Mg2+ binding site [ion binding]; other site 234621017932 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 234621017933 active site 234621017934 Ap6A binding site [chemical binding]; other site 234621017935 nudix motif; other site 234621017936 metal binding site [ion binding]; metal-binding site 234621017937 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 234621017938 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 234621017939 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 234621017940 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 234621017941 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 234621017942 DNA binding residues [nucleotide binding] 234621017943 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 234621017944 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 234621017945 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 234621017946 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 234621017947 active site 234621017948 FMN binding site [chemical binding]; other site 234621017949 substrate binding site [chemical binding]; other site 234621017950 putative catalytic residue [active] 234621017951 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 234621017952 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 234621017953 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 234621017954 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 234621017955 catalytic residues [active] 234621017956 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 234621017957 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 234621017958 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 234621017959 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 234621017960 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 234621017961 active site 234621017962 metal binding site [ion binding]; metal-binding site 234621017963 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 234621017964 ParB-like nuclease domain; Region: ParB; smart00470 234621017965 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 234621017966 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 234621017967 P-loop; other site 234621017968 Magnesium ion binding site [ion binding]; other site 234621017969 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 234621017970 Magnesium ion binding site [ion binding]; other site 234621017971 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 234621017972 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 234621017973 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 234621017974 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 234621017975 DNA binding residues [nucleotide binding] 234621017976 drug binding residues [chemical binding]; other site 234621017977 dimer interface [polypeptide binding]; other site 234621017978 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 234621017979 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 234621017980 G-X-X-G motif; other site 234621017981 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 234621017982 RxxxH motif; other site 234621017983 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 234621017984 hypothetical protein; Validated; Region: PRK00041 234621017985 ribonuclease P; Reviewed; Region: rnpA; PRK03459 234621017986 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399