-- dump date 20140620_025722 -- class Genbank::CDS -- table cds_note -- id note YP_700023.1 tc: 3.A.1 YP_700024.1 tc: 3.A.1 YP_700029.1 bifunctional YP_700045.1 tc: 3.A.3 YP_700046.1 tc: 3.A.3 YP_700065.1 tc: 2.A.1.3 YP_700115.1 tc: 1.A.35 YP_700132.1 bifunctional YP_700151.1 tc: 2.A.3 YP_700165.1 with CobST catalyzes the formation of cobyrinic acid a,c-diamide from hydrogenobyrinic acid a,c-diamide in an ATP-dependent manner; involved in porphyrin and chlorophyll metabolism; vitamin B12 metabolism YP_700191.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates YP_700220.1 tc: 3.A.1.2 YP_700222.1 tc: 3.A.1.3 YP_700247.1 tc: 2.A.3 YP_700257.1 bifunctional; tc: 2.A.19.1.1 YP_700265.1 tc: 3.A.1.17 YP_700266.1 tc: 3.A.1.17 YP_700267.1 tc: 3.A.1.17 YP_700295.1 tc: 2.A.1.6 YP_700318.1 tc: 2.A.1 YP_700353.1 catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia YP_700362.1 tc: 2.A.1.3 YP_700375.1 tc: 2.A.1.15 YP_700393.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_700397.1 tc: 2.A.1.6 YP_700401.1 bifunctional YP_700409.1 tc: 2.A.1.15.1 YP_700424.1 tc: 2.A.1.3 YP_700442.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; the rhizobia and high GC gram-positive bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the R. leguminosarum protein in this cluster is transcribed under anaerobic conditions and is not necessary for growth YP_700476.1 bifunctional YP_700509.1 catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate YP_700510.1 catalyzes the formation of acetyl-CoA from acetalaldehyde YP_700512.1 catalyzes the cleavage of 3-(2,3-dihydroxyphenyl) propionate into 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate; part of the 3-phenylpropionic acid degradation pathway; member of the protocatechuate 4,5-dioxygenase family YP_700515.1 tc: 2.A.1.6 YP_700533.1 AcsA; in Sinorhizobium meliloti this enzyme is required for acetoacetate activation; similar to acetyl-CoA synthase YP_700548.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate YP_700549.1 similar to full-length Gnd, these proteins seems to have a truncated C-terminal 6PGD domainin; in Methylobacillus flagellatus this gene is essential for NAD+-dependent oxidation of 6-phosphogluconate YP_700557.1 tc: 2.A.1.3 YP_700565.1 Represses a number of genes involved in the response to DNA damage YP_700590.1 Catalyzes the deamination of cytosine to uracil and ammonia YP_700591.1 tc: 2.A.3 YP_700592.1 Catalyzes the deamination of cytosine to uracil and ammonia YP_700606.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis YP_700624.1 homologs found only in other rhodococci YP_700642.1 tc: 1.A.1 YP_700645.1 tc: 2.A.72.1.1 YP_700657.1 tc: 2.A.11 YP_700677.1 homologs found only in other rhodococci YP_700717.1 catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates YP_700720.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate YP_700748.1 bifunctional YP_700781.1 bifunctional YP_700787.1 bifunctional; tc: 2.A.1.15 YP_700794.1 tc: 3.A.1.3 YP_700795.1 tc: 3.A.1.3 YP_700804.1 tc: 2.A.1.6 YP_700810.1 tc: 3.A.1.2 YP_700811.1 tc: 3.A.1.2 YP_700812.1 tc: 3.A.1.2 YP_700828.1 TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes YP_700829.1 catalyzes the formation of 2-dehydropantoate from (R)-pantoate YP_700845.1 long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors YP_700846.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis YP_700852.1 tc: 2.A.1.3 YP_700868.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA YP_700872.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters UDP disphosphate which reduces the pool of lipid carrier available to the cell YP_700875.1 tc: 3.A.1.14 YP_700876.1 tc: 3.A.1.14.5 YP_700877.1 with HmuTU is involved in the transport of hemin YP_700881.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors YP_700889.1 catalyzes the formation of malate from glyoxylate and acetyl-CoA YP_700892.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine YP_700897.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor YP_700909.1 tc: 2.A.1.3 YP_700912.1 synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains YP_700913.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP YP_700918.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs YP_700920.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer YP_700924.1 catalyzes the phosphorylation of NAD to NADP YP_700928.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr) YP_700929.1 responsible for recognizing base lesions in the genome and initiating base excision DNA repair YP_700930.1 tc: 3.A.1 YP_700931.1 tc: 3.A.1 YP_700934.1 activates fatty acids by binding to coenzyme A YP_700935.1 catalyzes the formation of arginine from (N-L-arginino)succinate YP_700936.1 catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming YP_700937.1 regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes YP_700938.1 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation YP_700939.1 catalyzes the formation of N-acetyl-l-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine YP_700940.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate YP_700941.1 bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate YP_700942.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate YP_700944.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily YP_700945.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily YP_700947.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit YP_700955.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate YP_700962.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion YP_700964.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; in Mycobacterium tuberculosis the C-terminal UPF0157 domain appears to be necessary for proper folding of the N-terminal domain YP_700965.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins YP_700967.1 tc: 3.A.1.3 YP_700968.1 tc: 3.A.1.3 YP_700969.1 tc: 3.A.1.3 YP_700976.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair YP_700977.1 tc: 3.A.1.4 YP_700978.1 tc: 3.A.1.4 YP_700979.1 tc: 3.A.1.4 YP_700980.1 tc: 3.A.1.4 YP_700981.1 tc: 3.A.1.4 YP_700989.1 tc: 3.A.1 YP_700992.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_700996.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein YP_700997.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis YP_700998.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate YP_700999.1 involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water YP_701001.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine YP_701006.1 PR-AMP cyclohydrolase; functions in histidine biosynthesis from PRPP; converts 1-(5-phosphoribosyl)-AMP to 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxyamide during the histidine biosynthesis pathway; binds zinc and magnesium; forms homodimers YP_701007.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase YP_701009.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide and the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)anthranilate; involved in histidine and tryptophan biosynthesis YP_701011.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide YP_701012.1 tc: 2.A.1 YP_701014.1 catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis YP_701015.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis YP_701016.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer YP_701021.1 catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide YP_701022.1 catalyzes the formation of oxaloacetate from L-aspartate YP_701023.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate YP_701028.1 catalyzes the formation of biotin from dethiobiotin and sulfur 2 S-adenosyl-L-methionine YP_701033.1 catalyzes the fumarate and succinate interconversion; fumarate reductase is used under anaerobic conditions with glucose or glycerol as carbon source YP_701034.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol YP_701038.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium YP_701039.1 catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine YP_701040.1 catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate YP_701048.1 tc: 2.A.1.3 YP_701050.1 catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic YP_701051.1 catalyzes the formation of acetate from pyruvate YP_701054.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase YP_701058.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis YP_701062.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function YP_701063.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 2 subfamily; some organisms carry two different copies of this enzyme; in some organisms, the type 2 subfamily is associated with resistance to the antibiotic pseudomonic acid (mupirocin) YP_701070.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function YP_701072.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis YP_701073.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis YP_701075.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation YP_701076.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan YP_701078.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate YP_701082.1 MraZ; UPF0040; crystal structure shows similarity to AbrB YP_701111.1 contains 3'-5'exonuclease domain YP_701113.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate YP_701129.1 bifunctional YP_701130.1 catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole YP_701131.1 catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole YP_701132.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids YP_701133.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein YP_701134.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides YP_701138.1 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein YP_701139.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group YP_701144.1 tc: 2.A.1.2 YP_701146.1 tc: 3.A.1.12 YP_701147.1 tc: 3.A.1.12 YP_701148.1 tc: 3.A.1.12 YP_701151.1 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme YP_701154.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate YP_701161.1 bifunctional YP_701173.1 CobD; CbiD in Salmonella; converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group YP_701181.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC YP_701184.1 carries the fatty acid chain in fatty acid biosynthesis YP_701185.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP YP_701196.1 synthesizes RNA primers at the replication forks YP_701198.1 dGTPase family type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate YP_701202.1 Catalyzes a two-step reaction, first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_701207.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA YP_701213.1 tc: 3.A.3 YP_701214.1 catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions YP_701218.1 catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia YP_701220.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome YP_701227.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase YP_701228.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion YP_701229.1 Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons YP_701231.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_701234.1 catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite YP_701235.1 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP YP_701243.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. tuberculosis this protein regulates polyketide synthases and secreted or membrane proteins YP_701248.1 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP YP_701249.1 bifunctional; includes: sulfate adenylyltransferase subunit 1; adenylylsulfate kinase YP_701252.1 bifunctional; tc: 3.A.1.6.1 YP_701253.1 bifunctional; tc: 3.A.1.6.1 YP_701254.1 bifunctional; tc: 3.A.1.6 YP_701255.1 bifunctional; tc: 3.A.1.6.1 YP_701260.1 binds to the ribosome on the universally-conserved alpha-sarcin loop YP_701263.1 tc: 1.A.8 YP_701267.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase YP_701279.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria YP_701282.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway YP_701284.1 tc: 2.A.1.6.4 YP_701288.1 catalyzes the reversible formation of diaminobutyrate and 2-oxoglutarate from glutamate and L-aspartic beta-semialdehyde YP_701289.1 N-acetyldiaminobutyrate dehydratase; catalyzes the formation of the osmoprotectant ecotoine from gamma-N-acetyl-alpha,gamma-diaminobutyric acid YP_701292.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis YP_701293.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication YP_701294.1 involved in the peptidyltransferase reaction during translation YP_701296.1 bifunctional YP_701297.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate YP_701300.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain YP_701303.1 bifunctional; tc: 2.A.21 YP_701312.1 tc: 3.A.1.14 YP_701314.1 involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth YP_701322.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_701324.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate YP_701326.1 tc: 2.A.1.6 YP_701327.1 tc: 3.A.1.2 YP_701328.1 tc: 3.A.1.2 YP_701329.1 tc: 3.A.1.2 YP_701330.1 tc: 2.A.1.3 YP_701343.1 tc: 2.A.1.1 YP_701350.1 catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis YP_701351.1 binds and unfolds substrates as part of the ClpXP protease YP_701353.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates YP_701354.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates YP_701355.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer YP_701358.1 catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity YP_701363.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function YP_701375.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence YP_701377.1 tc: 9.B.62.1 YP_701384.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer YP_701392.1 tc: 2.A.1 YP_701397.1 3'-5' exoribonuclease specific for small oligoribonuclotides YP_701402.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids YP_701408.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine YP_701409.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs YP_701417.1 involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA YP_701418.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate YP_701421.1 tc: 3.A.1 YP_701425.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain YP_701427.1 tc: 2.A.1.14.7 YP_701428.1 tc: 2.A.1.14.7 YP_701431.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis YP_701441.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_701444.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane YP_701445.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit YP_701446.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit YP_701447.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit YP_701448.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex YP_701449.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel. YP_701450.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0 YP_701451.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 YP_701456.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 YP_701457.1 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome YP_701458.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes YP_701459.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate YP_701460.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine YP_701461.1 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine YP_701463.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase YP_701475.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_701483.1 tc: 2.A.1.6 YP_701490.1 in Rhizobium meliloti this protein is involved in the synthesis of nodulation factors that are active on the roots of alfalfa; catalyzes formation of activated sulfate intermediate; converts ATP and sulfate to diphosphate and adenylylsulfate and then ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; the activated intermediate is transferred to the nodulation factors by NodH; may interact with NodP and NodQ; similar to the CysD and CysN proteins from EScherichia coli involved in cysteine biosynthesis YP_701491.1 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP YP_701498.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates YP_701506.1 tc: 2.A.1.6 YP_701507.1 tc: 2.A.1.3 YP_701511.1 catalyzes the formation of 3-hydroxy-2-methylpropanoate from 3-hydroxy-2-methylpropanoyl-CoA YP_701520.1 tc: 8.A.7.1.1 YP_701521.1 tc: 4.A.1.1 YP_701522.1 tc: 4.A.1.1 YP_701523.1 tc: 4.A.1.1 YP_701535.1 catalyzes the conversion of shikimate to 3-dehydroshikimate YP_701540.1 tc: 2.A.40 YP_701543.1 tc: 2.A.46.1.1 YP_701556.1 activates fatty acids by binding to coenzyme A YP_701565.1 tc: 2.A.1.21 YP_701569.1 tc: 3.A.1 YP_701570.1 tc: 3.A.1.17 YP_701571.1 tc: 3.A.1 YP_701591.1 tc: 2.A.1.6 YP_701594.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis YP_701599.1 bifunctional YP_701600.1 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates YP_701602.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not YP_701606.1 tc: 2.A.39 YP_701619.1 catalyzes the ATP-dependent formation of a phosphodiester at the site of a single-strand break in duplex DNA YP_701673.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function YP_701679.1 tc: 2.A.33 YP_701709.1 tc: 3.A.1.24 YP_701710.1 tc: 3.A.1.24 YP_701711.1 tc: 3.A.1.24 YP_701728.1 tc: 3.A.1.24 YP_701729.1 tc: 3.A.1.24 YP_701730.1 tc: 3.A.1.5 YP_701731.1 tc: 3.A.1.5 YP_701732.1 tc: 3.A.1.5 YP_701733.1 tc: 3.A.1.5 YP_701734.1 tc: 3.A.1.5 YP_701759.1 tc: 2.A.3 YP_701765.1 tc: 2.A.23.1 YP_701777.1 tc: 2.A.3 YP_701813.1 in some organisms the DhaK and DhaL subunits are encoded by separate genes; in others they are fused; functions along with DhaM to phosphorylate dihydroxyacetone YP_701817.1 bifunctional YP_701822.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate YP_701823.1 tc: 2.A.1.6 YP_701831.1 tc: 2.A.1.15.5 YP_701833.1 in Corynebacterium glutamicum this enzyme catalyzes the conversion of maleylpyruvate into fumarylpyruvate in a glutathione-independent gentisate pathway; dependent on mycothiol YP_701837.1 tc: 2.A.1.15 YP_701860.1 Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues YP_701861.1 tc: 2.A.53 YP_701862.1 tc: 3.A.1.3 YP_701863.1 tc: 3.A.1.3 YP_701864.1 tc: 3.A.1.3 YP_701890.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_701891.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_701892.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit YP_701893.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance YP_701897.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_701905.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_701906.1 tc: 2.A.7 YP_701918.1 tc: 2.A.1.3 YP_701930.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter YP_701931.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme YP_701945.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit YP_701947.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA YP_701948.1 binds directly to 23S ribosomal RNA YP_701949.1 Modulates Rho-dependent transcription termination YP_701950.1 forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force YP_701951.1 functions as a heterodimer along with HadA or HadC in fatty acid biosynthesis; fatty acid synthase type II; FAS-II YP_701953.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group have the CXXC motif YP_701954.1 nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription YP_701955.1 metalloprotease YP_701958.1 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone YP_701962.1 SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis YP_701966.1 catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate YP_701968.1 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA YP_701972.1 tc: 2.A.20 YP_701978.1 tc: 3.A.1.105 YP_701979.1 tc: 3.A.1.105 YP_701983.1 tc: 2.A.3 YP_701986.1 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate YP_702002.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway YP_702015.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate YP_702017.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis YP_702018.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins YP_702019.1 modulates transcription in response to the NADH/NAD(+) redox state YP_702026.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate YP_702035.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate YP_702040.1 tc: 2.A.1 YP_702047.1 tc: 2.A.1.6 YP_702051.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis YP_702059.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate YP_702061.1 produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine YP_702064.1 tc: 2.A.1.14 YP_702083.1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor is a general stress response regulator; expressed in stationary phase and under nitrogen depletion and cold shock YP_702085.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine YP_702086.1 converts (S)-3-hydroxybutanoyl-CoA to 3-acetoacetyl-CoA YP_702091.1 tc: 3.A.1.4 YP_702092.1 tc: 3.A.1.4 YP_702093.1 tc: 3.A.1.4 YP_702094.1 tc: 3.A.1.4 YP_702095.1 tc: 3.A.1.4 YP_702099.1 tc: 2.A.1 YP_702101.1 catalyzes the hydrolysis of allophanate YP_702105.1 E3 component of alpha keto acid dehydrogenase complexes LpdC; forms a homodimer; binds one molecule of FAD monomer; catalyzes NAD+-dependent oxidation of dihydrolipoyl cofactors that are covalently linked to the E2 component YP_702111.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth YP_702119.1 catalyzes the degradation of histidine to urocanate and ammmonia YP_702124.1 catalyzes the decarboxylaton of phospatidyl-L-sering to phosphatidylethanolamine YP_702130.1 subunit A of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_702131.1 subunit C of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_702132.1 subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone YP_702133.1 subunit E of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in S. meliloti it is known to be involved specifically with K+ transport YP_702134.1 subunit F of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_702135.1 subunit G of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in S. meliloti it is known to be involved specifically with K+ transport YP_702137.1 ATP-dependent carboxylate-amine ligase YP_702141.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_702147.1 required for the synthesis of the hydromethylpyrimidine moiety of thiamine YP_702148.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine YP_702152.1 tc: 3.A.1.105 YP_702153.1 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate YP_702156.1 Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate YP_702159.1 tc: 3.A.1.3 YP_702161.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA YP_702162.1 catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate YP_702167.1 homologs found only in other rhodococci YP_702186.1 tc: 3.A.1.5 YP_702187.1 tc: 3.A.1.5 YP_702188.1 tc: 3.A.1.5 YP_702189.1 tc: 3.A.1.5 YP_702194.1 tc: 3.A.1.3 YP_702195.1 tc: 3.A.1.3 YP_702196.1 tc: 3.A.1.3 YP_702212.1 catalyzes the formation of precorrin 6x from precorrin 5 YP_702213.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived YP_702232.1 homologs found only in other rhodococci YP_702234.1 tc: 2.A.3.1.7 YP_702242.1 tc: 3.A.1.23 YP_702243.1 tc: 3.A.1.23 YP_702259.1 tc: 2.A.1.14 YP_702262.1 catalyzes the formation of (E)-3-(methoxycarbonyl)pent-2-enedioate and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and trans-aconitate YP_702266.1 tc: 2.A.1.6.2 YP_702270.1 activates fatty acids by binding to coenzyme A YP_702277.1 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine YP_702285.1 protein p43; inner membrane protein that exports enterobactin to the periplasmic space; member of the major facilitator superfamily (MFS) of transporters YP_702328.1 tc: 2.A.1.1 YP_702330.1 bifunctional; includes: 4-hydroxy-2-oxoglutarate aldolase; 2- dehydro-3-deoxy-phosphogluconate aldolase YP_702331.1 catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate YP_702332.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate YP_702350.1 catalyzes the degradation of 2-hydro-1,2-dihydroxy benzoate to catechol YP_702351.1 tc: 2.A.1.15.5 YP_702352.1 catalyzes the coenzyme A dependent formation of succinyl-CoA from 2-oxoglutarate and ferredoxin YP_702359.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate YP_702362.1 Catalyzes the conversion of citrate to isocitrate YP_702364.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this protein is involved in expression of ribosome-associated gene products in stationary phase YP_702368.1 bifunctional YP_702380.1 tc: 2.A.1.6 YP_702382.1 proposed role in polysaccahride synthesis YP_702387.1 tc: 2.A.1.3 YP_702436.1 tc: 2.A.1.6.6 YP_702437.1 tc: 2.A.3.1 YP_702446.1 initiates steroid ring degradation; catalyzes the transhydrogenation of 3-keto-4-ene-steroid to 3-keto-1,4-diene-steroid e.g., progesterone to 1,4-androstadiene-3,17-dione YP_702464.1 tc: 2.A.1.6 YP_702480.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_702481.1 activates fatty acids by binding to coenzyme A YP_702488.1 tc: 2.A.21 YP_702502.1 catalyzes the formation of protocatechuate from 4-hydroxybenzoate YP_702505.1 tc: 2.A.1.15 YP_702508.1 tc: 3.A.1.15 YP_702509.1 tc: 3.A.1.15 YP_702511.1 tc: 3.A.1.15 YP_702525.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. bovis this protein has been shown to be involved in expression of antigenic proteins YP_702527.1 catalyzes the formation of malate from glyoxylate and acetyl-CoA YP_702528.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_702529.1 paralogs to the E1 component of pyruvate dehydrogenase subunit E1 YP_702531.1 tc: 2.A.39.3 YP_702535.1 catalyzes the formation of S-ureidoglycolate and urea from allantoate YP_702537.1 catalyzes the formation of 2-hydroxy-3-oxopropanoate (tartronate semialdehyde) from two molecules of glyoxylate YP_702542.1 tc: 2.A.23.1.3 YP_702547.1 involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth YP_702552.1 tc: 3.A.1.12 YP_702553.1 tc: 3.A.1.12 YP_702554.1 tc: 3.A.1.12 YP_702555.1 tc: 3.A.1.12 YP_702565.1 tc: 3.A.1.105 YP_702566.1 tc: 3.A.1.105 YP_702571.1 catalyzes the formation of phenylacetaldehyde from 2-phenylethylamine YP_702572.1 tc: 2.A.3 YP_702575.1 tc: 2.A.3 YP_702582.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_702603.1 homologs found only in other rhodococci YP_702613.1 activates fatty acids by binding to coenzyme A YP_702636.1 AcsA; in Sinorhizobium meliloti this enzyme is required for acetoacetate activation; similar to acetyl-CoA synthase YP_702640.1 homologs found only in other rhodococci YP_702645.1 tc: 2.A.1.6 YP_702651.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_702658.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_702670.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_702679.1 bifunctional YP_702683.1 forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm YP_702689.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_702697.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_702744.1 activates fatty acids by binding to coenzyme A YP_702750.1 tc: 2.A.1.6 YP_702752.1 bifunctional YP_702758.1 catalyzes the formation of benzaldehyde from benzoylformate YP_702759.1 tc: 2.A.1.15 YP_702763.1 tc: 2.A.1.3 YP_702767.1 tc: 3.A.1.1 YP_702768.1 tc: 3.A.1.1 YP_702769.1 tc: 3.A.1.1 YP_702770.1 tc: 3.A.1.1 YP_702779.1 allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide YP_702797.1 catalyzes the formation of phenylacetaldehyde from 2-phenylethylamine YP_702798.1 tc: 2.A.3 YP_702812.1 tc: 2.A.21.7.1 YP_702821.1 with PaaBCDE catalyzes the hydroxylation of phenylacetyl-CoA; involved in phenylacetate degradation YP_702822.1 with PaaBCDE catalyzes the hydroxylation of phenylacetyl-CoA YP_702827.1 catalyzes the ring cleavage reaction in phenylacetate degradation and the formation of 3-hydroxyacyl-CoA from crotonyl-CoA YP_702847.1 bifunctional; tc: 2.A.7 YP_702850.1 tc: 2.A.1.1 YP_702854.1 bifunctional; tc: 2.A.25.1.2 YP_702869.1 tc: 3.A.1.2 YP_702870.1 tc: 3.A.1.2 YP_702886.1 bifunctional; tc: 2.A.1.15 YP_702890.1 E3 component of pyruvate complex; catalyzes the oxidation of dihydrolipoamide to lipoamide YP_702891.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group YP_702893.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine YP_702894.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein YP_702896.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate YP_702900.1 tc: 2.A.47 YP_702904.1 tc: 2.A.1.6 YP_702907.1 catalyzes the formation of fumarate from aspartate YP_702908.1 tc: 2.A.23.1 YP_702918.1 tc: 3.A.1 YP_702946.1 catalyzes the formation of benzaldehyde from benzoylformate YP_702950.1 tc: 2.A.1.15 YP_702959.1 tc: 2.A.1.1 YP_702972.1 tc: 2.A.47.1 YP_702974.1 tc: 2.A.3.1.4 YP_702978.1 tc: 2.A.1.6 YP_702980.1 bifunctional YP_702982.1 tc: 2.A.1.3 YP_702983.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_702985.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_702989.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_702994.1 tc: 2.A.3 YP_703005.1 tc: 2.A.3 YP_703010.1 tc: 2.A.1.6.6 YP_703012.1 catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis YP_703031.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_703036.1 tc: 2.A.51.1 YP_703060.1 bifunctional YP_703062.1 NADP-dependent semialdehyde dehydrogenase; part of alternative pathway from alpha-ketoglutarate to succinate YP_703067.1 tc: 2.A.1.6.6 YP_703082.1 tc: 3.A.1.125.1 YP_703083.1 tc: 3.A.1.125.1 YP_703103.1 tc: 3.A.1.10 YP_703104.1 tc: 3.A.1.10 YP_703105.1 tc: 3.A.1.10.1 YP_703107.1 tc: 3.A.3 YP_703176.1 tc: 2.A.1.15 YP_703182.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_703184.1 catalyzes the formation of 2-hydroxy-3-oxopropanoate (tartronate semialdehyde) from two molecules of glyoxylate YP_703189.1 tc: 2.A.14 YP_703251.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate YP_703254.1 bifunctional; tc: 2.A.1.6.4 YP_703263.1 catalyzes the demethylation of N-methyl-L-tryptophan forming L-tryptophan and formaldehyde; FAD-binding; can also catalyze the demethylation of other N-methyl amino acids YP_703265.1 catalyzes the formation of 2,5-dioxopentanoate from 5-dehydro-4-deoxy-D-glucarate YP_703270.1 tc: 3.A.1.5 YP_703271.1 tc: 3.A.1.5 YP_703272.1 tc: 3.A.1.5 YP_703273.1 tc: 3.A.1.15 YP_703279.1 E3 component of pyruvate complex; catalyzes the oxidation of dihydrolipoamide to lipoamide YP_703316.1 tc: 2.A.1.6.2 YP_703327.1 tc: 2.A.3 YP_703329.1 tc: 2.A.59 YP_703330.1 tc: 2.A.59 YP_703331.1 bifunctional YP_703334.1 bifunctional YP_703338.1 E3 component of pyruvate complex; catalyzes the oxidation of dihydrolipoamide to lipoamide YP_703343.1 tc: 2.A.1.14 YP_703352.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis YP_703388.1 catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate; involved in growth under gluconeogenic conditions and in glycolytic activity at high ATP concentrations in Corynebacterium; NAD and NADP dependent YP_703390.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk YP_703391.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit YP_703392.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA YP_703393.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 YP_703397.1 bifunctional YP_703412.1 tc: 3.A.1.1 YP_703413.1 tc: 3.A.1.1 YP_703414.1 tc: 3.A.1.1 YP_703415.1 tc: 3.A.1.1 YP_703417.1 tc: 3.A.1.14 YP_703421.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_703430.1 tc: 3.A.1.3 YP_703431.1 tc: 3.A.1.3 YP_703437.1 tc: 2.A.1.15.4 YP_703453.1 tc: 2.A.40.1 YP_703458.1 tc: 2.A.1 YP_703460.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) YP_703490.1 tc: 2.A.3 YP_703498.1 tc: 3.A.3.5 YP_703500.1 tc: 3.A.3.5 YP_703539.1 bifunctional; tc: 2.A.21 YP_703543.1 catalyzes the formation of acetyl phosphate and sulfite from 2-sulfoacetaldehyde; is active when grown on taurine as a sole carbon source YP_703548.1 with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate YP_703549.1 tc: 2.A.1.3.5 YP_703550.1 tc: 2.A.3.1.4 YP_703555.1 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate YP_703557.1 specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport YP_703558.1 tc: 2.A.75 YP_703561.1 bifunctional YP_703571.1 tc: 2.A.1.1 YP_703577.1 tc: 2.A.7 YP_703583.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase YP_703587.1 tc: 2.A.1.2 YP_703597.1 tc: 3.A.1 YP_703598.1 tc: 3.A.1 YP_703599.1 tc: 3.A.1 YP_703600.1 tc: 3.A.1 YP_703606.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription: in Mycobacterium bovis this protein has been shown to be active at high temperatures and during stationary phase YP_703617.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA YP_703623.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria YP_703625.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates YP_703626.1 in Escherichia coli transcription of this gene is enhanced by polyamines YP_703627.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself. YP_703628.1 binds the polymerase to DNA and acts as a sliding clamp YP_703629.1 similar to full-length Gnd, these proteins seems to have a truncated C-terminal 6PGD domainin; in Methylobacillus flagellatus this gene is essential for NAD+-dependent oxidation of 6-phosphogluconate YP_703630.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA YP_703635.1 negatively supercoils closed circular double-stranded DNA YP_703641.1 negatively supercoils closed circular double-stranded DNA YP_703652.1 integral membrane protein involved in inhibition of the Z-ring formation YP_703654.1 aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity YP_703676.1 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate YP_703691.1 catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_703694.1 regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity YP_703706.1 tc: 2.A.1 YP_703715.1 tc: 2.A.53 YP_703716.1 tc: 3.A.3 YP_703726.1 tc: 2.A.36 YP_703741.1 tc: 2.A.1 YP_703747.1 tc: 2.A.1.14 YP_703749.1 catalyzes the formation of 2,5-dioxopentanoate from 5-dehydro-4-deoxy-D-glucarate YP_703760.1 tc: 3.A.1.105 YP_703761.1 tc: 3.A.1.105 YP_703775.1 tc: 3.A.1.3 YP_703783.1 homologs found only in other rhodococci YP_703800.1 tc: 2.A.1.6 YP_703815.1 tc: 2.A.1.6 YP_703818.1 tc: 2.A.3 YP_703824.1 catalyzes the formation of acetyl-CoA from acetalaldehyde YP_703825.1 catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate YP_703847.1 tc: 2.A.1.1 YP_703850.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis YP_703861.1 tc: 2.A.1 YP_703866.1 bifunctional; tc: 2.A.1.15 YP_703877.1 tc: 2.A.3 YP_703886.1 tc: 3.A.1.5 YP_703887.1 tc: 3.A.1.5 YP_703888.1 tc: 3.A.1.5 YP_703889.1 tc: 3.A.1.5 YP_703890.1 tc: 3.A.1.5.1 YP_703899.1 NADP-dependent semialdehyde dehydrogenase; part of alternative pathway from alpha-ketoglutarate to succinate YP_703902.1 activates fatty acids by binding to coenzyme A YP_703912.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_703916.1 tc: 2.A.1 YP_703917.1 activates fatty acids by binding to coenzyme A YP_703918.1 tc: 2.A.1.6 YP_703921.1 activates fatty acids by binding to coenzyme A YP_703922.1 tc: 2.A.1.6 YP_703927.1 tc: 3.A.1 YP_703928.1 tc: 2.A.1 YP_703933.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_703959.1 bifunctional YP_703963.1 catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia YP_703988.1 catalyzes the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis YP_703996.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_704011.1 catalyzes the formation of decaprenylphosphoryl-5-phosphoribose from phosphoribose diphosphate and decaprenyl phosphate YP_704019.1 activates fatty acids by binding to coenzyme A YP_704036.1 bifunctional YP_704040.1 tc: 3.A.1.2 YP_704041.1 tc: 3.A.1.2 YP_704042.1 tc: 3.A.1.2 YP_704049.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_704067.1 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity YP_704069.1 tc: 3.A.1.103 YP_704070.1 tc: 3.A.1.103 YP_704091.1 tc: 2.A.1.6 YP_704104.1 catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate YP_704120.1 tc: 3.A.1 YP_704121.1 tc: 3.A.1 YP_704129.1 this tRNA synthetase lacks the tRNA anticodon interaction domain; instead this enzyme modifies tRNA(Asp) with glutamate by esterifying glutamate to the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of queosine generating a modified nucleoside at the first anticodon position of tRNAAsp; the modified tRNA does not bind elongation factor Tu YP_704144.1 with FepCDG is involved in the transport of ferric enterobactin YP_704147.1 tc: 2.A.49 YP_704148.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA YP_704153.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_704154.1 multifunctional; includes: enoyl-CoA hydratase; delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase; 3-hydroxyacyl-CoA dehydrogenase; 3- hydroxybutyryl-CoA epimerase YP_704160.1 involved in a recombinational process of DNA repair, independent of the recBC complex YP_704162.1 tc: 2.A.1.3 YP_704168.1 tc: 2.A.7.3 YP_704189.1 bifunctional YP_704190.1 tc: 3.A.1.14 YP_704198.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_704201.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_704204.1 bifunctional YP_704210.1 Catalyzes the reversible phosphorolysis of 5'-deoxy-5'- methylthioadenosine (MTA) to adenine and 5-methylthio-D-ribose-1- phosphate YP_704217.1 tc: 2.A.1.3 YP_704220.1 tc: 3.A.1.1 YP_704221.1 tc: 3.A.1.1 YP_704222.1 tc: 3.A.1.1 YP_704225.1 tc: 3.A.1 YP_704236.1 tc: 2.A.53 YP_704240.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation. YP_704241.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde YP_704265.1 tc: 3.A.4.1.1 YP_704266.1 tc: 3.A.4.1.1 YP_704278.1 tc: 2.A.1.6 YP_704280.1 Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA YP_704281.1 tc: 3.A.1.5 YP_704282.1 tc: 3.A.1.5 YP_704283.1 tc: 3.A.1.5 YP_704284.1 tc: 3.A.1.5 YP_704288.1 tc: 3.A.7 YP_704294.1 tc: 2.A.1.6 YP_704301.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity YP_704302.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA YP_704306.1 tc: 3.A.1.3 YP_704307.1 tc: 3.A.1.3 YP_704308.1 tc: 3.A.1.3 YP_704309.1 tc: 3.A.1.3 YP_704313.1 tc: 2.A.1.3 YP_704324.1 tc: 2.A.1 YP_704342.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_704343.1 tc: 2.A.1.3 YP_704352.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer YP_704359.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine YP_704360.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5) YP_704364.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1 YP_704388.1 tc: 3.A.1.208 YP_704396.1 tc: 2.A.3.1 YP_704397.1 catalyzes the formation of fumarate from aspartate YP_704399.1 non-specific DNA-binding; scans chromosomes during sporulation for DNA-damage; delays initiation of sporulation; participates in a checkpoint signaling cascade for cell-cycle progression and DNA repair YP_704401.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents YP_704404.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers YP_704405.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate YP_704406.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA YP_704421.1 tc: 3.A.1.15 YP_704422.1 tc: 3.A.1 YP_704423.1 tc: 3.A.1.15 YP_704425.1 bifunctional YP_704440.1 tc: 3.A.1.105 YP_704441.1 tc: 3.A.1.105 YP_704452.1 catalyzes the transformation of hydroxyatrazine to N-isopropylammelide and ethylamine in the atrazine degradation pathway. YP_704462.1 tc: 2.A.39.3 YP_704468.1 catalyzes the formation of L-tryptophan from indole and L-serine YP_704476.1 initiates steroid ring degradation; catalyzes the transhydrogenation of 3-keto-4-ene-steroid to 3-keto-1,4-diene-steroid e.g., progesterone to 1,4-androstadiene-3,17-dione YP_704478.1 catalyzes the formation of acetyl-CoA from acetalaldehyde YP_704479.1 catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate YP_704500.1 catalyzes the formation of fumarate from aspartate YP_704501.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer YP_704504.1 tc: 2.A.1 YP_704526.1 tc: 2.A.1.2 YP_704538.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_704543.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_704562.1 bifunctional YP_704563.1 bifunctional YP_704564.1 bifunctional YP_704570.1 catalyzed the formation of 2-ketoglutarate from 2-hydroxyglutarate YP_704584.1 catalyzes the formation of glutamate and formamide from N-formimidoyl-L-glutamate YP_704585.1 catalyzes the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate, the third step in the histidine degradation pathway YP_704586.1 catalyzes the formation of 4-imidazolone-5-propanoate from urocanate during histidine metabolism YP_704587.1 tc: 2.A.39 YP_704596.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_704619.1 activates fatty acids by binding to coenzyme A; in Mycobacterium may be involved in virulence YP_704622.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_704627.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_704632.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_704633.1 activates fatty acids by binding to coenzyme A; in Mycobacterium may be involved in virulence YP_704635.1 activates fatty acids by binding to coenzyme A YP_704639.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_704654.1 tc: 3.A.1.119 YP_704655.1 tc: 3.A.1 YP_704681.1 tc: 2.A.7.1 YP_704707.1 tc: 3.A.1 YP_704708.1 tc: 3.A.1.20 YP_704710.1 tc: 3.A.1 YP_704714.1 tc: 3.A.1.2 YP_704720.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis YP_704722.1 tc: 2.A.1.6 YP_704724.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate YP_704730.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide YP_704734.1 tc: 3.A.1.105 YP_704735.1 tc: 3.A.1.105 YP_704736.1 bifunctional YP_704743.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_704756.1 tc: 2.A.1.3 YP_704760.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase YP_704765.1 tc: 2.A.23.1.3 YP_704770.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_704777.1 catalyzes the removal of amino acids from the N termini of peptides YP_704778.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_704783.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway YP_704784.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis YP_704789.1 catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate YP_704805.1 tc: 3.A.1.7.1 YP_704806.1 tc: 3.A.1.7.1 YP_704807.1 tc: 3.A.1.7.1 YP_704808.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation YP_704824.1 tc: 3.A.1.4 YP_704825.1 tc: 3.A.1.4 YP_704826.1 tc: 3.A.1.4 YP_704827.1 tc: 3.A.1.4 YP_704839.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_704841.1 tc: 2.A.11.1 YP_704846.1 tc: 2.A.1 YP_704852.1 tc: 3.A.1 YP_704865.1 tc: 2.A.1.8 YP_704867.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine YP_704868.1 tc: 3.A.1 YP_704869.1 tc: 3.A.1 YP_704870.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive YP_704872.1 tc: 2.A.6.5 YP_704874.1 tc: 2.A.76.1.1 YP_704880.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription YP_704881.1 tc: 3.A.1 YP_704882.1 tc: 3.A.1.17 YP_704883.1 tc: 3.A.1 YP_704884.1 tc: 3.A.1 YP_704886.1 tc: 2.A.1 YP_704893.1 tc: 3.A.1 YP_704894.1 tc: 3.A.1.17 YP_704895.1 tc: 3.A.1 YP_704897.1 tc: 3.A.1 YP_704926.1 tc: 3.A.1.2 YP_704927.1 tc: 3.A.1 YP_704928.1 tc: 3.A.1.2 YP_704931.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate YP_704932.2 forms citrate from oxaloacetate and acetyl-CoA; functions in TCA cycle YP_704933.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate YP_704934.1 tc: 2.A.1 YP_704937.1 type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH YP_704952.1 bifunctional YP_704957.1 tc: 3.A.1 YP_704961.1 tc: 3.A.1.120 YP_704972.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_704976.1 tc: 2.A.36.6.1 YP_704984.1 tc: 2.A.21.7 YP_704986.1 tc: 3.A.1.3 YP_704987.1 catalyzes the ATP-dependent formation of a phosphodiester at the site of a single-strand break in duplex DNA and has been shown to have polymerase activity YP_704995.1 tc: 3.A.1 YP_705006.1 tc: 2.A.55.3.1 YP_705008.1 catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol YP_705019.1 bifunctional; tc: 2.A.53 YP_705021.1 tc: 2.A.1.3 YP_705026.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis YP_705028.1 tc: 2.A.1 YP_705030.1 involved in the biosynthesis of phosphatidylinositol mannosides (PIMs); the enzyme from Mycobacterium tuberculosis can phosphorylate a variety of amphipathic lipids YP_705032.1 tc: 2.A.1.3 YP_705035.1 tc: 2.A.1.3 YP_705038.1 converts (S)-3-hydroxybutanoyl-CoA to 3-acetoacetyl-CoA YP_705043.1 3'-5' exonuclease of DNA polymerase III YP_705046.1 catalyzes the ATP-dependent formation of a phosphodiester at the site of a single-strand break in duplex DNA; in mycobacteria LigC has weak intrinsic nick joining activities and is not essential for growth YP_705053.1 tc: 3.A.1.1 YP_705054.1 tc: 3.A.1.1 YP_705055.1 tc: 3.A.1.1 YP_705056.1 tc: 3.A.1.1 YP_705067.1 tc: 2.A.1.6.6 YP_705070.1 tc: 2.A.1.6 YP_705076.1 tc: 2.A.1.6 YP_705082.1 tc: 3.A.1.3 YP_705088.1 tc: 2.A.39 YP_705092.1 tc: 3.A.1 YP_705097.1 tc: 2.A.17 YP_705115.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine YP_705119.1 catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using GTP YP_705138.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_705139.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_705145.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs YP_705193.1 tc: 2.A.7 YP_705197.1 tc: 3.A.1 YP_705202.1 tc: 2.A.11.1 YP_705224.1 bifunctional YP_705226.1 tc: 2.A.3 YP_705228.1 catalyzes the formation of 4-aminobutanoate from 4-aminobutanal; involved in putrescine degradation YP_705249.1 bifunctional YP_705255.1 tc: 2.A.1 YP_705269.1 bifunctional YP_705273.1 tc: 2.A.3.1 YP_705280.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis YP_705287.1 tc: 3.A.1.5 YP_705288.1 tc: 3.A.1.5 YP_705289.1 tc: 3.A.1 YP_705290.1 tc: 3.A.1.5 YP_705299.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates YP_705307.1 tc: 2.A.1.3 YP_705323.1 catalyzes the formation of 4-aminobutanoate from 4-aminobutanal; involved in putrescine degradation YP_705326.1 tc: 2.A.3 YP_705335.1 bifunctional YP_705352.1 tc: 2.A.1.3 YP_705403.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor YP_705435.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria YP_705437.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion YP_705447.1 activates fatty acids by binding to coenzyme A YP_705456.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate YP_705462.1 tc: 2.A.46.1.1 YP_705474.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate YP_705482.1 tc: 2.A.1.3 YP_705489.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis YP_705494.1 bifunctional YP_705505.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family YP_705511.1 catalyzes the interconversion of succinyl-CoA and succinate YP_705512.1 Catalyzes the only substrate-level phosphorylation in the TCA cycle YP_705516.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate YP_705517.1 involved in de novo purine biosynthesis YP_705532.1 tc: 2.A.3 YP_705535.1 catalyzes the formation of phenylacetaldehyde from 2-phenylethylamine YP_705536.1 catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate YP_705539.1 tc: 2.A.3 YP_705546.1 tc: 2.A.1 YP_705552.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit YP_705553.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif YP_705554.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif YP_705555.1 required for 70S ribosome assembly YP_705557.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome YP_705558.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not YP_705578.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate YP_705582.1 bifunctional; tc: 3.A.1 YP_705584.1 bifunctional YP_705585.1 PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA YP_705591.1 catalyzes the degradation of arginine to citruline and ammonia YP_705596.1 tc: 2.A.15.1.1 YP_705600.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content YP_705608.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin YP_705614.1 tc: 2.A.23.1.3 YP_705615.1 UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter YP_705617.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits YP_705621.1 catalyzes the phosphorylation of 4-diphosphocytidyl-2-C-methyl-D-erythritol in the nonmevalonate pathway of isoprenoid biosynthesis YP_705622.1 tc: 3.A.1.120 YP_705623.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_705630.1 activates fatty acids by binding to coenzyme A YP_705631.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation YP_705632.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response YP_705654.1 tc: 2.A.3 YP_705660.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP YP_705661.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis YP_705664.1 catalyzes the formation of 5-aminovulinate from (S)-4-amino-5-oxopentanoate YP_705674.1 tc: 2.A.66.2 YP_705691.1 Involved in the biosynthetic pathways of fatty acids, phospholipids, lipopolysaccharides, and oligosaccharides YP_705697.1 functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase Era YP_705713.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis YP_705727.1 tc: 2.A.1.3 YP_705733.1 initiates steroid ring degradation; catalyzes the transhydrogenation of 3-keto-4-ene-steroid to 3-keto-1,4-diene-steroid e.g., progesterone to 1,4-androstadiene-3,17-dione YP_705735.1 catalyzes the formation of acetyl-CoA from acetalaldehyde YP_705736.1 catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate YP_705750.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_705757.1 activates fatty acids by binding to coenzyme A YP_705776.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_705780.1 catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine YP_705781.1 catalyzes the formation of 2-oxobutanoate from L-threonine YP_705785.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus YP_705792.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis YP_705794.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate YP_705799.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle YP_705800.1 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese YP_705803.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides YP_705805.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway YP_705814.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 YP_705827.1 molecular chaperone YP_705840.1 tc: 1.A.11 YP_705844.1 Catalyzes the transfer of electrons from NADH to quinone YP_705845.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen YP_705846.1 Catalyzes the transfer of electrons from NADH to quinone YP_705847.1 Catalyzes the transfer of electrons from NADH to quinone YP_705848.1 Catalyzes the transfer of electrons from NADH to quinone YP_705850.1 Catalyzes the transfer of electrons from NADH to quinone YP_705851.1 Catalyzes the transfer of electrons from NADH to quinone YP_705852.1 Catalyzes the transfer of electrons from NADH to quinone YP_705853.1 Catalyzes the transfer of electrons from NADH to quinone YP_705854.1 Catalyzes the transfer of electrons from NADH to quinone YP_705855.1 Catalyzes the transfer of electrons from NADH to ubiquinone YP_705856.1 Catalyzes the transfer of electrons from NADH to quinone YP_705857.1 Catalyzes the transfer of electrons from NADH to quinone YP_705864.1 involved in the fifth mannose transfer of phosphatidylinositol mannoside synthesis YP_705865.1 4-alpha-hydroxytetrahydrobiopterin dehydratase activity; catalyzes the formation of (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7, 8-dihydro-6H-pterin from (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7, 8-tetrahydro-4a-hydroxypterin; functions in recycling tetrahydrobiopterin (BH4) in phenylalanine hydroxylase reaction YP_705879.1 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase; catalyzes radical-mediated transfer of hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO); functions in F420 biosynthesis YP_705882.1 catalyzes the formation of N-succinyl-LL-2,6-diaminopimelate from N-succinyl-L-2-amino-6-oxopimelate in lysine biosynthesis YP_705889.1 activates fatty acids by binding to coenzyme A YP_705899.1 catalyzes the formation of succinate and diaminoheptanedioate from succinyldiaminoheptanedioate YP_705902.1 activates fatty acids by binding to coenzyme A; may be involved in acyclic terpene utilization YP_705910.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate YP_705915.1 mediates the export of protein precursors bearing twin-arginine signal peptides YP_705923.1 tc: 3.A.1.1 YP_705924.1 tc: 3.A.1.1 YP_705925.1 tc: 3.A.1.1 YP_705926.1 tc: 3.A.1.1 YP_705927.1 tc: 2.A.1.3 YP_705932.1 tc: 1.A.35 YP_705936.1 tc: 3.A.1.12 YP_705937.1 tc: 3.A.1.12 YP_705938.1 tc: 3.A.1.12 YP_705939.1 tc: 3.A.1.12 YP_705946.1 tc: 3.A.1 YP_705947.1 kgd; produces succinic semialdehyde; part of alternative pathway from alpha-ketoglutarate to succinate; essential for normal growth YP_705948.1 tc: 3.A.1.201 YP_705950.1 tc: 3.A.1 YP_705978.1 tc: 3.A.1 YP_705983.1 tc: 3.A.1.125 YP_705984.1 tc: 3.A.1.125 YP_705998.1 tc: 3.A.1 YP_706010.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_706018.1 tc: 2.A.3.5 YP_706020.1 catalyzes the formation of acetaldehyde from ethanolamine YP_706022.1 tc: 2.A.1.6 YP_706023.1 activates fatty acids by binding to coenzyme A YP_706035.1 AcsA; in Sinorhizobium meliloti this enzyme is required for acetoacetate activation; similar to acetyl-CoA synthase YP_706040.1 bifunctional YP_706041.1 bifunctional YP_706050.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation YP_706051.1 multifunctional; includes: enoyl-CoA hydratase; delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase; 3-hydroxyacyl-CoA dehydrogenase; 3-hydroxybutyryl-CoA epimerase YP_706053.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_706054.1 activates fatty acids by binding to coenzyme A YP_706063.1 tc: 3.A.1.105 YP_706064.1 tc: 3.A.1.105 YP_706065.1 tc: 3.A.1.105 YP_706067.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex YP_706068.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin YP_706069.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA YP_706070.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel YP_706071.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation YP_706072.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA YP_706073.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center YP_706074.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation YP_706075.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e YP_706076.1 one of the stabilizing components for the large ribosomal subunit YP_706077.1 primary binding protein; helps mediate assembly; involved in translation fidelity YP_706078.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase YP_706079.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel YP_706080.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 YP_706081.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group appear to contain the zinc-binding motif YP_706082.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit YP_706083.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance YP_706084.1 binds 5S rRNA along with protein L5 and L25 YP_706085.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance YP_706086.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7 YP_706087.1 late assembly protein YP_706088.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase YP_706089.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP YP_706090.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn YP_706091.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine YP_706092.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 YP_706093.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif YP_706094.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA YP_706095.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 YP_706096.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination YP_706097.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme YP_706098.1 is a component of the macrolide binding site in the peptidyl transferase center YP_706105.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit YP_706106.1 forms a direct contact with the tRNA during translation YP_706108.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate YP_706112.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source YP_706115.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer YP_706120.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity YP_706124.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring YP_706125.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is not essential for growth YP_706127.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. bovis this protein has been shown to be involved in expression of antigenic proteins YP_706131.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this protein is involved in expression of ribosome-associated gene products in stationary phase YP_706134.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate YP_706135.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate YP_706137.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway YP_706152.1 Catalyzes the rate-limiting step in dNTP synthesis YP_706158.1 tc: 3.A.1 YP_706159.1 tc: 3.A.1.14 YP_706160.1 tc: 3.A.1.14 YP_706162.1 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis. It is not the major replicative DNA polymerase. YP_706169.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate YP_706171.1 Catalyzes the conversion of acetyl-CoA and L-homoserine to CoA and O-acetyl-L-homoserine YP_706172.1 catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol YP_706173.1 Converts isocitrate to alpha ketoglutarate YP_706176.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_706179.1 catalyzes the oxidation of malate to oxaloacetate YP_706180.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase YP_706181.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol YP_706184.1 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis YP_706185.1 Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate YP_706186.1 catalyzes the formation of inosine from adenosine YP_706192.1 catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation YP_706197.1 catalyzes the reduction of nonspecific electron acceptors such as 2,6-dimethyl-1,4-benzoquinone and 5-hydroxy-1,4-naphthaquinone; does not have lipoamide dehydrogenase activity YP_706212.1 catalyzes the formation of 2-aminoadipate 6-semiladehyde and glutamate from lysine and 2-oxoglutarate YP_706225.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell YP_706234.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway YP_706246.1 catalyzes the addition of gamma linked glutamate to 7,8-didemethyl-8-hydroxy-5-deazariboflavin coenzyme F420-0) YP_706247.1 catalyzes the formation of the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) and GMP from actyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) YP_706251.1 converts mannose-6-phosphate to mannose-1-phosphate; the resulting product is then converted to GDP-mannose by ManC which is then used in the synthesis of mannose-containing glycoconjugates that are important for mediating entry into host cells YP_706255.1 tc: 2.A.3.3 YP_706257.1 catalyzes the formation of L-homocysteine from S-adenosyl-L-homocysteine YP_706258.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP) YP_706264.2 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins YP_706273.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis YP_706276.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response YP_706296.1 The proteins in this cluster have high sequence similarity to MoeB and are possibly involved in the synthesis of molybdopterin, but there has been no biochemical or physiological characterization. There is also no genetic linkage to other molybdopterin cofactor synthesis proteins. These proteins are similar to a Pseudomonas stutzeri protein which is essential to pyridine-2,6-bis(thiocarboxylic acid) synthesis that possibly activates a substrate by adenylation YP_706299.1 tc: 2.A.1.17 YP_706303.1 catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane YP_706313.1 tc: 1.A.1 YP_706314.1 can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates YP_706329.1 tc: 3.A.1.16 YP_706330.1 tc: 3.A.1 YP_706332.1 activates fatty acids by binding to coenzyme A YP_706338.1 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1 YP_706343.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation YP_706346.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling YP_706347.1 catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate YP_706360.1 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis YP_706362.1 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z YP_706365.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers YP_706366.1 Catalyzes hydrolysis of n-ribosyl-purine into a purine and d-ribose YP_706373.1 in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF YP_706374.1 Catalyzes the rate-limiting step in dNTP synthesis YP_706375.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE YP_706384.1 tc: 3.A.1 YP_706400.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs YP_706402.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB YP_706406.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain YP_706407.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_706412.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis YP_706413.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_706417.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis YP_706419.1 acetolactate synthase large subunit; catalyzes the formation of 2-acetolactate from pyruvate YP_706420.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit YP_706421.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis YP_706422.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate YP_706424.1 tc: 2.A.1 YP_706426.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_706430.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate YP_706431.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D YP_706434.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate YP_706436.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate YP_706437.1 catalyzes the formation of cysteine and 2-oxobutanoate from cystathionine YP_706438.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli YP_706441.1 catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP YP_706443.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine YP_706445.1 required for 70S ribosome assembly YP_706447.1 catalyzes branch migration in Holliday junction intermediates YP_706448.1 biotin-containing enzyme that catalyzes a two step carboxylation of pyruvate to oxaloacetate YP_706450.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA YP_706453.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity YP_706454.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases YP_706458.1 catalyzes the hydrolysis of acylphosphate YP_706463.1 catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein; also involved in adenylylating and deadelnylyating GlnK YP_706466.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity YP_706468.1 Essential for efficient processing of 16S rRNA YP_706469.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA YP_706473.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site YP_706475.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids YP_706478.1 tc: 2.A.1.6 YP_706503.1 tc: 2.A.1.2 YP_706509.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit YP_706510.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu YP_706511.1 Catalyzes the phosphorylation of UMP to UDP YP_706512.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs YP_706517.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance YP_706519.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate YP_706521.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis YP_706527.1 tc: 2.A.3 YP_706530.1 tc: 3.A.1 YP_706531.1 tc: 3.A.1 YP_706532.1 tc: 3.A.1 YP_706536.1 catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation YP_706538.1 tc: 3.A.1 YP_706541.1 catalyzes the reduction of mycothione or glutathione to mycothione or glutathione disulfide YP_706543.1 malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate YP_706546.1 catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide YP_706547.1 responsible for the amidation of carboxylic groups at position A and C of cobyrinic acid or hydrogenobrynic acid YP_706549.1 tc: 2.A.1.3 YP_706559.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) YP_706567.1 tc: 2.A.1.3 YP_706572.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins YP_706573.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination YP_706575.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex YP_706577.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock YP_706579.1 tc: 2.A.66 YP_706582.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs YP_706584.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities YP_706585.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence YP_706590.1 tc: 2.A.1 YP_706596.1 bifunctional YP_706612.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_706621.1 can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates YP_706626.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_706640.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria YP_706669.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis YP_706676.1 flavin dependent thymidylate synthase; ThyX; thymidylate synthase complementing protein; catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate; the enzyme from Mycobacterium tuberculosis forms homotetramers; uses FAD as a cofactor YP_706677.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis YP_706683.1 catalyzes the conversion of l-glutamate to a-N-acetyl-l-glutamate in arginine biosynthesis YP_706695.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs YP_706696.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities YP_706701.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A) YP_706705.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity YP_706707.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate YP_706716.1 tc: 2.A.40 YP_706718.1 Represses a number of genes involved in the response to DNA damage YP_706725.1 tc: 2.A.1.6.4 YP_706743.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma factors in this cluster are active during stationary phase YP_706753.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released YP_706759.1 catalyzes the formation of dUMP from dUTP YP_706764.1 tc: 8.A.5 YP_706765.1 tc: 8.A.5 YP_706766.1 tc: 2.A.3 YP_706770.1 tc: 3.A.1.105 YP_706771.1 tc: 3.A.1.105.1 YP_706773.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate YP_706774.1 tc: 2.A.1.1 YP_706775.1 tc: 3.A.1.14 YP_706778.1 tc: 3.A.1.17 YP_706779.1 tc: 3.A.1.17 YP_706780.1 tc: 3.A.1.17 YP_706782.1 multifunctional; includes: enoyl-CoA hydratase; delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase; 3-hydroxyacyl-CoA dehydrogenase; 3-hydroxybutyryl-CoA epimerase YP_706788.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III YP_706789.1 catalyzes the formation of protoporphyrin IX from protoporphyrinogen IX YP_706791.1 bifunctional YP_706798.1 tc: 2.A.1 YP_706802.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr) YP_706805.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA YP_706808.1 with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate YP_706812.1 with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate YP_706816.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity YP_706817.1 plays an essential role in ATP-dependent branch migration of the Holliday junction YP_706818.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration YP_706820.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane YP_706821.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF YP_706823.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis YP_706828.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG YP_706852.1 tc: 3.A.1 YP_706860.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria YP_706864.1 bifunctional YP_706878.1 bifunctional YP_706891.1 homologs found only in other rhodococci YP_706938.1 homologs found only in other rhodococci YP_706960.1 tc: 3.A.1 YP_706961.1 tc: 3.A.1 YP_706970.1 tc: 3.A.1.17 YP_706971.1 tc: 3.A.1.17 YP_706972.1 tc: 3.A.1.17 YP_706992.1 tc: 2.A.1.6 YP_706994.1 catalyzes the formation of 3-hydroxy-2-methylpropanoate from 3-hydroxy-2-methylpropanoyl-CoA YP_707007.1 tc: 2.A.1 YP_707010.1 tc: 2.A.1.3 YP_707020.1 bifunctional YP_707023.1 tc: 2.A.1.6 YP_707051.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes YP_707057.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_707058.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function YP_707060.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate YP_707062.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis YP_707064.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis YP_707067.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA YP_707068.1 Regulates rRNA biosynthesis by transcriptional antitermination YP_707069.1 regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity YP_707070.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis YP_707071.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis YP_707073.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers YP_707074.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity YP_707077.1 Essential for recycling GMP and indirectly, cGMP YP_707079.1 catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine YP_707080.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase YP_707081.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity YP_707085.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth YP_707089.1 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate YP_707090.1 bifunctional; includes: diaminohydroxyphosphoribosylaminopyrimidine deaminase; 5-amino-6-(5-phosphoribosylamino)uracil reductase YP_707091.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine YP_707092.1 bifunctional enzyme DHBP synthase/GTP cyclohydrolase II; functions in riboflavin synthesis; converts GTP to 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine; converts ribulose 5-phopshate to 3,4-dihydroxy-2-butanone 4-phosphate YP_707093.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not YP_707095.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision YP_707100.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway YP_707101.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate YP_707103.1 catalyzes the formation of oxaloacetate from phosphoenolpyruvate YP_707106.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate YP_707107.1 catalyzes the reversible formation of D-erythrose 4-phosphate and D-fructose 6-phosphate from sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate YP_707108.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase YP_707109.1 converts protoheme IX and farnesyl diphosphate to heme O YP_707115.1 tc: 3.A.1.105 YP_707120.1 tc: 3.A.1 YP_707126.1 tc: 3.A.1.120 YP_707129.1 Catalyzes the conversion of citrate to isocitrate YP_707136.1 Catalyzes a key regulatory step in fatty acid biosynthesis YP_707137.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic YP_707156.1 MDM; functions in conversion of succinate to propionate YP_707157.1 functions in transport of arginine/ornithine; inner membrane ATPase that cleaves ATP and phosphorylates two periplasmic proteins that function as two distinct transport systems, the AO (arginine and ornithine) and LAO (lysine, arginine, and ornithine) periplasmic binding proteins YP_707161.1 bifunctional YP_707165.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate YP_707168.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate YP_707191.1 tc: 3.A.1.15 YP_707192.1 tc: 3.A.1.15 YP_707193.1 tc: 3.A.1.15 YP_707213.1 tc: 2.A.1 YP_707259.1 Converts cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol (PP-dihydrodiol) into 3-(2,3-dihydroxylphenyl)propionate YP_707276.1 homologs found only in other rhodococci YP_707278.1 homologs found only in other rhodococci YP_707288.1 catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate YP_707289.1 catalyzes the formation of acetyl-CoA from acetalaldehyde YP_707305.1 homologs found only in other rhodococci YP_707306.1 homologs found only in other rhodococci YP_707310.1 homologs found only in other rhodococci YP_707326.1 bifunctional YP_707330.1 homologs found only in other rhodococci YP_707331.1 homologs found only in other rhodococci YP_707339.1 homologs found only in other rhodococci YP_707347.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_707349.1 homologs found only in other rhodococci YP_707353.1 homologs found only in other rhodococci YP_707362.1 tc: 2.A.1.6 YP_707367.1 Converts cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol (PP-dihydrodiol) into 3-(2,3-dihydroxylphenyl)propionate YP_707373.1 tc: 3.A.1 YP_707374.1 tc: 3.A.1.17 YP_707375.1 tc: 3.A.1.17 YP_707376.1 tc: 3.A.1 YP_707377.1 homologs found only in other rhodococci YP_707383.1 tc: 2.A.1.15 YP_707384.1 homologs found only in other rhodococci YP_707385.1 homologs found only in other rhodococci YP_707407.1 tc: 3.A.1.2 YP_707408.1 tc: 3.A.1.2 YP_707409.1 tc: 3.A.1.2 YP_707414.1 tc: 2.A.1.6 YP_707446.1 tc: 2.A.1.3 YP_707479.1 catalyzes the reversible formation of D-erythrose 4-phosphate and D-fructose 6-phosphate from sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate YP_707514.1 catalyzes the formation of acetate from pyruvate YP_707567.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria YP_707580.1 ATP-dependent carboxylate-amine ligase YP_707615.1 homologs found only in other rhodococci YP_707617.1 homologs found only in other rhodococci YP_707652.2 forms citrate from oxaloacetate and acetyl-CoA; functions in TCA cycle YP_707668.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; forms a heterodimer with subunit 1 to form the P protein YP_707669.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; forms a heterodimer with subunit 2 to form the P protein YP_707678.1 catalyzes the formation of phenylacetaldehyde from 2-phenylethylamine YP_707683.1 homologs found only in other rhodococci YP_707706.1 tc: 3.A.1.2 YP_707707.1 tc: 3.A.1.2.1 YP_707708.1 tc: 3.A.1.2 YP_707709.1 tc: 3.A.1.2 YP_707738.1 tc: 3.A.1 YP_707765.1 tc: 3.A.1 YP_707766.1 tc: 3.A.1.125 YP_707767.1 tc: 3.A.1.125 YP_707788.1 homologs found only in other rhodococci YP_707816.1 homologs found only in other rhodococci YP_707838.1 tc: 2.A.3 YP_707874.1 bifunctional YP_707888.1 bifunctional YP_707919.1 homologs found only in other rhodococci YP_707923.1 homologs found only in other rhodococci YP_707926.1 homologs found only in other rhodococci YP_707937.1 homologs found only in other rhodococci YP_707946.1 homologs found only in other rhodococci YP_708005.1 bifunctional YP_708014.1 forms citrate from oxaloacetate and acetyl-CoA; functions in TCA cycle YP_708018.1 bifunctional YP_708054.1 bifunctional YP_708068.1 homologs found only in other rhodococci YP_708090.1 tc: 2.A.3 YP_708095.1 bifunctional YP_708135.1 homologs found only in other rhodococci YP_708136.1 homologs found only in other rhodococci YP_708137.1 homologs found only in other rhodococci YP_708192.1 tc: 3.A.1.4 YP_708193.1 tc: 3.A.1.4 YP_708202.1 homologs found only in other rhodococci YP_708220.1 catalyzes the formation of acetyl-CoA from acetalaldehyde YP_708221.1 catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate YP_708225.1 initiates steroid ring degradation; catalyzes the transhydrogenation of 3-keto-4-ene-steroid to 3-keto-1,4-diene-steroid e.g., progesterone to 1,4-androstadiene-3,17-dione YP_708242.1 initiates steroid ring degradation; catalyzes the transhydrogenation of 3-keto-4-ene-steroid to 3-keto-1,4-diene-steroid e.g., progesterone to 1,4-androstadiene-3,17-dione YP_708246.1 tc: 3.A.1.5 YP_708247.1 tc: 3.A.1.5 YP_708248.1 tc: 3.A.1.5 YP_708249.1 tc: 3.A.1.5 YP_708250.1 tc: 3.A.1.5 YP_708283.1 tc: 3.A.1.2 YP_708284.1 tc: 3.A.1.2 YP_708294.1 homologs found only in other rhodococci YP_708340.1 homologs found only in other rhodococci YP_708357.1 homologs found only in other rhodococci YP_708358.1 homologs found only in other rhodococci YP_708365.1 homologs found only in other rhodococci YP_708371.1 homologs found only in other rhodococci YP_708373.1 homologs found only in other rhodococci YP_708375.1 homologs found only in other rhodococci YP_708390.1 homologs found only in other rhodococci YP_708399.1 homologs found only in other rhodococci YP_708405.1 homologs found only in other rhodococci YP_708410.1 homologs found only in other rhodococci YP_708413.1 homologs found only in other rhodococci YP_708415.1 homologs found only in other rhodococci YP_708420.1 homologs found only in other rhodococci YP_708421.1 homologs found only in other rhodococci YP_708422.1 homologs found only in other rhodococci YP_708423.1 homologs found only in other rhodococci YP_708438.1 homologs found only in other rhodococci YP_708446.1 homologs found only in other rhodococci YP_708447.1 homologs found only in other rhodococci YP_708455.1 homologs found only in other rhodococci YP_708458.1 homologs found only in other rhodococci YP_708459.1 homologs found only in other rhodococci YP_708460.1 homologs found only in other rhodococci YP_708462.1 homologs found only in other rhodococci YP_708463.1 catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate YP_708475.1 homologs found only in other rhodococci YP_708477.1 Converts cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol (PP-dihydrodiol) into 3-(2,3-dihydroxylphenyl)propionate YP_708493.1 homologs found only in other rhodococci YP_708498.1 tc: 2.A.1 YP_708520.1 aliphatic amidase; catalyzes the hydrolysis of short-chain aliphatic amides to their organic acids and can also transfer the acyl moiety of short-chain amides to hydroxylamine to form hydroxamates YP_708525.1 tc: 2.A.52.1 YP_708544.1 homologs found only in other rhodococci YP_708546.1 tc: 2.A.1.15 YP_708552.1 homologs found only in other rhodococci YP_708553.1 tc: 3.A.1 YP_708554.1 tc: 3.A.1 YP_708555.1 tc: 3.A.1 YP_708556.1 tc: 3.A.1 YP_708562.1 Converts cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol (PP-dihydrodiol) into 3-(2,3-dihydroxylphenyl)propionate YP_708567.1 homologs found only in other rhodococci YP_708581.1 bifunctional YP_708582.1 homologs found only in other rhodococci YP_708599.1 homologs found only in other rhodococci YP_708613.1 tc: 2.A.1.3 YP_708659.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_708670.1 tc: 3.A.1.4 YP_708671.1 tc: 3.A.1.4 YP_708692.1 tc: 2.A.1.3 YP_708696.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer YP_708709.1 bifunctional YP_708716.1 tc: 2.A.1.3 YP_708718.1 tc: 2.A.1.3 YP_708719.1 tc: 2.A.1.3 YP_708725.1 homologs found only in other rhodococci YP_708731.1 homologs found only in other rhodococci YP_708736.1 bifunctional YP_708782.1 bifunctional; tc: 2.A.1.6.4 YP_708792.1 homologs found only in other rhodococci YP_708794.1 homologs found only in other rhodococci YP_708813.1 homologs found only in other rhodococci YP_708814.1 homologs found only in other rhodococci YP_708815.1 homologs found only in other rhodococci YP_708816.1 homologs found only in other rhodococci YP_708821.1 homologs found only in other rhodococci YP_708825.1 tc: 2.A.76 YP_708846.1 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase; catalyzes radical-mediated transfer of hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO); functions in F420 biosynthesis YP_708853.1 bifunctional YP_708863.1 bifunctional YP_708866.1 similar to full-length Gnd, these proteins seems to have a truncated C-terminal 6PGD domainin; in Methylobacillus flagellatus this gene is essential for NAD+-dependent oxidation of 6-phosphogluconate YP_708868.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family YP_708880.1 homologs found only in other rhodococci YP_708903.1 tc: 3.A.1 YP_708914.1 homologs found only in other rhodococci YP_708935.1 homologs found only in other rhodococci YP_708969.1 bifunctional YP_708972.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family YP_708973.1 activates fatty acids by binding to coenzyme A YP_708976.1 bifunctional YP_708979.1 tc: 3.A.1.2 YP_708980.1 tc: 3.A.1.2 YP_708981.1 tc: 3.A.1.2 YP_708995.1 Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA YP_709017.1 tc: 3.A.3 YP_709018.1 tc: 3.A.3.5 YP_709020.1 tc: 3.A.1 YP_709023.1 tc: 2.A.1 YP_709050.1 tc: 2.A.53 YP_709060.1 homologs found only in other rhodococci YP_709071.1 homologs found only in other rhodococci YP_709112.1 bifunctional YP_709127.1 homologs found only in other rhodococci YP_709129.1 homologs found only in other rhodococci YP_709132.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family YP_709133.1 similar to full-length Gnd, these proteins seems to have a truncated C-terminal 6PGD domainin; in Methylobacillus flagellatus this gene is essential for NAD+-dependent oxidation of 6-phosphogluconate YP_709137.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate