-- dump date 20140620_025831 -- class Genbank::misc_feature -- table misc_feature_note -- id note 632772000001 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 632772000002 DNA binding residues [nucleotide binding] 632772000003 Replicase family; Region: Replicase; pfam03090 632772000004 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 632772000005 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 632772000006 DNA binding residues [nucleotide binding] 632772000007 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 632772000008 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 632772000009 putative transposase OrfB; Reviewed; Region: PHA02517 632772000010 HTH-like domain; Region: HTH_21; pfam13276 632772000011 Integrase core domain; Region: rve; pfam00665 632772000012 Integrase core domain; Region: rve_3; cl15866 632772000013 Transposase; Region: HTH_Tnp_1; cl17663 632772000014 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 632772000015 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 632772000016 Probable transposase; Region: OrfB_IS605; pfam01385 632772000017 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 632772000018 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 632772000019 active site 632772000020 metal binding site [ion binding]; metal-binding site 632772000021 interdomain interaction site; other site 632772000022 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 632772000023 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 632772000024 Magnesium ion binding site [ion binding]; other site 632772000025 Cutinase; Region: Cutinase; pfam01083 632772000026 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 632772000027 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 632772000028 AAA-like domain; Region: AAA_10; pfam12846 632772000029 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 632772000030 Peptidase family M23; Region: Peptidase_M23; pfam01551 632772000031 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 632772000032 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 632772000033 N-acetyl-D-glucosamine binding site [chemical binding]; other site 632772000034 catalytic residue [active] 632772000035 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 632772000036 Integrase core domain; Region: rve_3; pfam13683 632772000037 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 632772000038 Helix-turn-helix domain; Region: HTH_38; pfam13936 632772000039 Integrase core domain; Region: rve; pfam00665 632772000040 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 632772000041 active site 632772000042 catalytic residues [active] 632772000043 DNA binding site [nucleotide binding] 632772000044 Int/Topo IB signature motif; other site 632772000045 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 632772000046 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 632772000047 active site 632772000048 catalytic residues [active] 632772000049 DNA binding site [nucleotide binding] 632772000050 Int/Topo IB signature motif; other site 632772000051 HTH-like domain; Region: HTH_21; pfam13276 632772000052 Transposase; Region: HTH_Tnp_1; cl17663 632772000053 Transposase; Region: HTH_Tnp_1; cl17663 632772000054 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 632772000055 non-specific DNA binding site [nucleotide binding]; other site 632772000056 salt bridge; other site 632772000057 sequence-specific DNA binding site [nucleotide binding]; other site 632772000058 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 632772000059 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 632772000060 non-specific DNA binding site [nucleotide binding]; other site 632772000061 salt bridge; other site 632772000062 sequence-specific DNA binding site [nucleotide binding]; other site 632772000063 Integrase core domain; Region: rve; pfam00665 632772000064 Integrase core domain; Region: rve_3; cl15866 632772000065 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 632772000066 Helix-turn-helix domain; Region: HTH_38; pfam13936 632772000067 Integrase core domain; Region: rve; pfam00665 632772000068 HTH-like domain; Region: HTH_21; pfam13276 632772000069 Integrase core domain; Region: rve; pfam00665 632772000070 Transposase; Region: HTH_Tnp_1; cl17663 632772000071 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 632772000072 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 632772000073 non-specific DNA binding site [nucleotide binding]; other site 632772000074 salt bridge; other site 632772000075 sequence-specific DNA binding site [nucleotide binding]; other site 632772000076 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 632772000077 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630 632772000078 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 632772000079 Walker A motif; other site 632772000080 ATP binding site [chemical binding]; other site 632772000081 Walker B motif; other site 632772000082 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 632772000083 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 632772000084 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 632772000085 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 632772000086 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 632772000087 NlpC/P60 family; Region: NLPC_P60; pfam00877 632772000088 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 632772000089 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 632772000090 active site 632772000091 catalytic site [active] 632772000092 substrate binding site [chemical binding]; other site 632772000093 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 632772000094 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 632772000095 Active Sites [active] 632772000096 CRISPR/Cas system-associated RAMP superfamily protein Csf3; Region: Csf3_U; cl11865 632772000097 Transcription factor WhiB; Region: Whib; pfam02467 632772000098 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 632772000099 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632772000100 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 632772000101 Walker A motif; other site 632772000102 ATP binding site [chemical binding]; other site 632772000103 Walker B motif; other site 632772000104 arginine finger; other site 632772000105 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 632772000106 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 632772000107 metal ion-dependent adhesion site (MIDAS); other site 632772000108 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 632772000109 AAA domain; Region: AAA_12; pfam13087 632772000110 Excisionase-like protein; Region: Exc; pfam07825 632772000111 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 632772000112 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 632772000113 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 632772000114 Helicase associated domain; Region: HA; pfam03457 632772000115 Helicase associated domain; Region: HA; pfam03457 632772000116 Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117 632772000117 PLD-like domain; Region: PLDc_2; pfam13091 632772000118 homodimer interface [polypeptide binding]; other site 632772000119 putative active site [active] 632772000120 catalytic site [active] 632772000121 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 632772000122 Helix-turn-helix domain; Region: HTH_38; pfam13936 632772000123 AAA ATPase domain; Region: AAA_16; pfam13191 632772000124 AAA domain; Region: AAA_22; pfam13401 632772000125 Walker A motif; other site 632772000126 ATP binding site [chemical binding]; other site 632772000127 Walker B motif; other site 632772000128 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 632772000129 Integrase core domain; Region: rve; pfam00665 632772000130 Integrase core domain; Region: rve_3; cl15866 632772000131 AAA domain; Region: AAA_22; pfam13401 632772000132 Bacterial TniB protein; Region: TniB; pfam05621 632772000133 TniQ; Region: TniQ; pfam06527 632772000134 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 632772000135 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 632772000136 PYR/PP interface [polypeptide binding]; other site 632772000137 dimer interface [polypeptide binding]; other site 632772000138 TPP binding site [chemical binding]; other site 632772000139 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 632772000140 Hemerythrin-like domain; Region: Hr-like; cd12108 632772000141 Fe binding site [ion binding]; other site 632772000142 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865 632772000143 putative hydrophobic ligand binding site [chemical binding]; other site 632772000144 Hypothetical protein TTHB210, a sigma(E)-regulated gene product found in Thermus thermophilus, and similar proteins; Region: TTHB210-like; cd11669 632772000145 oligomer interface [polypeptide binding]; other site 632772000146 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 632772000147 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 632772000148 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 632772000149 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 632772000150 Cytochrome P450; Region: p450; cl12078 632772000151 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 632772000152 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772000153 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772000154 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 632772000155 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 632772000156 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 632772000157 NAD(P) binding site [chemical binding]; other site 632772000158 catalytic residues [active] 632772000159 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 632772000160 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 632772000161 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 632772000162 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 632772000163 DDE superfamily endonuclease; Region: DDE_5; pfam13546 632772000164 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 632772000165 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 632772000166 Integrase core domain; Region: rve; pfam00665 632772000167 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 632772000168 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 632772000169 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 632772000170 Transposase; Region: HTH_Tnp_1; cl17663 632772000171 HTH-like domain; Region: HTH_21; pfam13276 632772000172 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 632772000173 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 632772000174 active site 632772000175 catalytic residues [active] 632772000176 DNA binding site [nucleotide binding] 632772000177 Int/Topo IB signature motif; other site 632772000178 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 632772000179 active site 632772000180 catalytic residues [active] 632772000181 DNA binding site [nucleotide binding] 632772000182 Int/Topo IB signature motif; other site 632772000183 Integrase core domain; Region: rve; pfam00665 632772000184 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 632772000185 Helix-turn-helix domain; Region: HTH_38; pfam13936 632772000186 Integrase core domain; Region: rve; pfam00665 632772000187 Integrase core domain; Region: rve_3; pfam13683 632772000188 TIR domain; Region: TIR_2; pfam13676 632772000189 DDE superfamily endonuclease; Region: DDE_3; pfam13358 632772000190 Winged helix-turn helix; Region: HTH_29; pfam13551 632772000191 Homeodomain-like domain; Region: HTH_32; pfam13565 632772000192 Integrase core domain; Region: rve; pfam00665 632772000193 Integrase core domain; Region: rve_3; pfam13683 632772000194 potential frameshift: common BLAST hit: gi|111019485|ref|YP_702457.1| non-ribosomal peptide synthetase 632772000195 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772000196 potential frameshift: common BLAST hit: gi|111019485|ref|YP_702457.1| non-ribosomal peptide synthetase 632772000197 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772000198 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772000199 potential frameshift: common BLAST hit: gi|111025329|ref|YP_707749.1| non-ribosomal peptide synthetase 632772000200 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772000201 active site 632772000202 CoA binding site [chemical binding]; other site 632772000203 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772000204 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772000205 acyl-activating enzyme (AAE) consensus motif; other site 632772000206 acyl-activating enzyme (AAE) consensus motif; other site 632772000207 potential frameshift: common BLAST hit: gi|111019485|ref|YP_702457.1| non-ribosomal peptide synthetase 632772000208 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 632772000209 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 632772000210 putative methyltransferase; Provisional; Region: PRK14967 632772000211 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 632772000212 Interferon-induced transmembrane protein; Region: CD225; pfam04505 632772000213 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 632772000214 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 632772000215 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 632772000216 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 632772000217 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 632772000218 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 632772000219 Integrase core domain; Region: rve_3; pfam13683 632772000220 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 632772000221 Helix-turn-helix domain; Region: HTH_38; pfam13936 632772000222 Integrase core domain; Region: rve; pfam00665 632772000223 Integrase core domain; Region: rve; pfam00665 632772000224 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 632772000225 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 632772000226 active site 632772000227 catalytic residues [active] 632772000228 DNA binding site [nucleotide binding] 632772000229 Int/Topo IB signature motif; other site 632772000230 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 632772000231 active site 632772000232 catalytic residues [active] 632772000233 DNA binding site [nucleotide binding] 632772000234 Int/Topo IB signature motif; other site 632772000235 HTH-like domain; Region: HTH_21; pfam13276 632772000236 Transposase; Region: HTH_Tnp_1; cl17663 632772000237 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 632772000238 Ligand Binding Site [chemical binding]; other site 632772000239 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 632772000240 CrcB-like protein; Region: CRCB; pfam02537 632772000241 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 632772000242 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 632772000243 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 632772000244 dimerization interface [polypeptide binding]; other site 632772000245 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 632772000246 dimer interface [polypeptide binding]; other site 632772000247 phosphorylation site [posttranslational modification] 632772000248 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632772000249 ATP binding site [chemical binding]; other site 632772000250 Mg2+ binding site [ion binding]; other site 632772000251 G-X-G motif; other site 632772000252 potential frameshift: common BLAST hit: gi|111025345|ref|YP_707765.1| ABC transporter membrane protein 632772000253 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 632772000254 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 632772000255 Walker A/P-loop; other site 632772000256 ATP binding site [chemical binding]; other site 632772000257 Q-loop/lid; other site 632772000258 ABC transporter signature motif; other site 632772000259 Walker B; other site 632772000260 D-loop; other site 632772000261 H-loop/switch region; other site 632772000262 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 632772000263 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 632772000264 Walker A/P-loop; other site 632772000265 ATP binding site [chemical binding]; other site 632772000266 Q-loop/lid; other site 632772000267 ABC transporter signature motif; other site 632772000268 Walker B; other site 632772000269 D-loop; other site 632772000270 H-loop/switch region; other site 632772000271 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 632772000272 active site 632772000273 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 632772000274 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632772000275 active site 632772000276 phosphorylation site [posttranslational modification] 632772000277 intermolecular recognition site; other site 632772000278 dimerization interface [polypeptide binding]; other site 632772000279 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 632772000280 DNA binding site [nucleotide binding] 632772000281 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 632772000282 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 632772000283 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 632772000284 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 632772000285 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 632772000286 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 632772000287 Interferon-induced transmembrane protein; Region: CD225; pfam04505 632772000288 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 632772000289 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 632772000290 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 632772000291 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 632772000292 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 632772000293 Predicted esterase [General function prediction only]; Region: COG0627 632772000294 Helix-turn-helix domain; Region: HTH_37; pfam13744 632772000295 Phage-related protein [Function unknown]; Region: COG4679 632772000296 Uncharacterized conserved protein [Function unknown]; Region: COG0398 632772000297 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 632772000298 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 632772000299 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 632772000300 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 632772000301 Domain of unknown function (DUF305); Region: DUF305; pfam03713 632772000302 Copper resistance protein D; Region: CopD; cl00563 632772000303 CopC domain; Region: CopC; pfam04234 632772000304 Ycf48-like protein; Provisional; Region: PRK13684 632772000305 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 632772000306 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 632772000307 Multicopper oxidase; Region: Cu-oxidase; pfam00394 632772000308 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 632772000309 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772000310 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 632772000311 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 632772000312 dimer interface [polypeptide binding]; other site 632772000313 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632772000314 catalytic residue [active] 632772000315 Penicillinase repressor; Region: Pencillinase_R; pfam03965 632772000316 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 632772000317 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 632772000318 catalytic residues [active] 632772000319 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 632772000320 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 632772000321 catalytic residues [active] 632772000322 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 632772000323 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 632772000324 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 632772000325 Peptidase family M23; Region: Peptidase_M23; pfam01551 632772000326 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 632772000327 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 632772000328 hydrophobic ligand binding site; other site 632772000329 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772000330 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772000331 hypothetical protein; Provisional; Region: PRK08317 632772000332 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772000333 S-adenosylmethionine binding site [chemical binding]; other site 632772000334 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 632772000335 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 632772000336 DNA binding residues [nucleotide binding] 632772000337 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772000338 S-adenosylmethionine binding site [chemical binding]; other site 632772000339 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632772000340 Walker A/P-loop; other site 632772000341 ATP binding site [chemical binding]; other site 632772000342 ABC transporter; Region: ABC_tran; pfam00005 632772000343 Q-loop/lid; other site 632772000344 ABC transporter signature motif; other site 632772000345 Walker B; other site 632772000346 D-loop; other site 632772000347 potential frameshift: common BLAST hit: gi|119867529|ref|YP_937481.1| putative ABC transporter membrane protein 632772000348 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 632772000349 metal-binding site [ion binding] 632772000350 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 632772000351 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 632772000352 Soluble P-type ATPase [General function prediction only]; Region: COG4087 632772000353 Domain of unknown function (DUF305); Region: DUF305; pfam03713 632772000354 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 632772000355 metal-binding site [ion binding] 632772000356 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 632772000357 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 632772000358 dimerization interface [polypeptide binding]; other site 632772000359 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 632772000360 dimer interface [polypeptide binding]; other site 632772000361 phosphorylation site [posttranslational modification] 632772000362 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632772000363 ATP binding site [chemical binding]; other site 632772000364 Mg2+ binding site [ion binding]; other site 632772000365 G-X-G motif; other site 632772000366 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 632772000367 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632772000368 active site 632772000369 phosphorylation site [posttranslational modification] 632772000370 intermolecular recognition site; other site 632772000371 dimerization interface [polypeptide binding]; other site 632772000372 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 632772000373 DNA binding site [nucleotide binding] 632772000374 Predicted membrane protein [Function unknown]; Region: COG3462 632772000375 Short C-terminal domain; Region: SHOCT; pfam09851 632772000376 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 632772000377 putative homodimer interface [polypeptide binding]; other site 632772000378 putative homotetramer interface [polypeptide binding]; other site 632772000379 putative allosteric switch controlling residues; other site 632772000380 putative metal binding site [ion binding]; other site 632772000381 putative homodimer-homodimer interface [polypeptide binding]; other site 632772000382 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 632772000383 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 632772000384 metal-binding site [ion binding] 632772000385 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 632772000386 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 632772000387 metal-binding site [ion binding] 632772000388 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772000389 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632772000390 putative substrate translocation pore; other site 632772000391 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 632772000392 Peptidase family M23; Region: Peptidase_M23; pfam01551 632772000393 Transposase; Region: DEDD_Tnp_IS110; pfam01548 632772000394 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 632772000395 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 632772000396 PhoD-like phosphatase; Region: PhoD; pfam09423 632772000397 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 632772000398 putative active site [active] 632772000399 putative metal binding site [ion binding]; other site 632772000400 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 632772000401 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 632772000402 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 632772000403 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632772000404 dimerization interface [polypeptide binding]; other site 632772000405 putative DNA binding site [nucleotide binding]; other site 632772000406 Transcriptional regulators [Transcription]; Region: MarR; COG1846 632772000407 putative Zn2+ binding site [ion binding]; other site 632772000408 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 632772000409 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 632772000410 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 632772000411 Coenzyme A binding pocket [chemical binding]; other site 632772000412 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 632772000413 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632772000414 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772000415 putative substrate translocation pore; other site 632772000416 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632772000417 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 632772000418 Walker A/P-loop; other site 632772000419 ATP binding site [chemical binding]; other site 632772000420 Q-loop/lid; other site 632772000421 ABC transporter signature motif; other site 632772000422 Walker B; other site 632772000423 D-loop; other site 632772000424 H-loop/switch region; other site 632772000425 ABC-2 type transporter; Region: ABC2_membrane; cl17235 632772000426 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 632772000427 RNA polymerase sigma factor SigZ; Provisional; Region: PRK09637 632772000428 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632772000429 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 632772000430 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 632772000431 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 632772000432 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 632772000433 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 632772000434 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 632772000435 Soluble P-type ATPase [General function prediction only]; Region: COG4087 632772000436 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632772000437 dimerization interface [polypeptide binding]; other site 632772000438 putative DNA binding site [nucleotide binding]; other site 632772000439 putative Zn2+ binding site [ion binding]; other site 632772000440 Protein of unknown function (DUF3703); Region: DUF3703; pfam12487 632772000441 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632772000442 putative DNA binding site [nucleotide binding]; other site 632772000443 putative Zn2+ binding site [ion binding]; other site 632772000444 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 632772000445 Peptidase family M23; Region: Peptidase_M23; pfam01551 632772000446 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865 632772000447 putative hydrophobic ligand binding site [chemical binding]; other site 632772000448 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 632772000449 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 632772000450 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 632772000451 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 632772000452 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 632772000453 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 632772000454 Copper resistance protein D; Region: CopD; pfam05425 632772000455 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 632772000456 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 632772000457 DNA binding residues [nucleotide binding] 632772000458 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 632772000459 Protein of unknown function (DUF3146); Region: DUF3146; pfam11344 632772000460 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 632772000461 TIGR03118 family protein; Region: PEPCTERM_chp_1 632772000462 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 632772000463 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 632772000464 Walker A/P-loop; other site 632772000465 ATP binding site [chemical binding]; other site 632772000466 Q-loop/lid; other site 632772000467 ABC transporter signature motif; other site 632772000468 Walker B; other site 632772000469 D-loop; other site 632772000470 H-loop/switch region; other site 632772000471 TOBE domain; Region: TOBE_2; pfam08402 632772000472 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 632772000473 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772000474 putative PBP binding loops; other site 632772000475 ABC-ATPase subunit interface; other site 632772000476 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772000477 dimer interface [polypeptide binding]; other site 632772000478 conserved gate region; other site 632772000479 ABC-ATPase subunit interface; other site 632772000480 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 632772000481 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 632772000482 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 632772000483 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772000484 active site 632772000485 CoA binding site [chemical binding]; other site 632772000486 AMP binding site [chemical binding]; other site 632772000487 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772000488 Acyltransferase family; Region: Acyl_transf_3; pfam01757 632772000489 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 632772000490 Peptidase family M23; Region: Peptidase_M23; pfam01551 632772000491 Penicillinase repressor; Region: Pencillinase_R; pfam03965 632772000492 Peptidase family M48; Region: Peptidase_M48; cl12018 632772000493 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 632772000494 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 632772000495 D-pathway; other site 632772000496 Putative ubiquinol binding site [chemical binding]; other site 632772000497 Low-spin heme (heme b) binding site [chemical binding]; other site 632772000498 Putative water exit pathway; other site 632772000499 Binuclear center (heme o3/CuB) [ion binding]; other site 632772000500 K-pathway; other site 632772000501 Putative proton exit pathway; other site 632772000502 MMPL family; Region: MMPL; pfam03176 632772000503 Sulfate transporter family; Region: Sulfate_transp; pfam00916 632772000504 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 632772000505 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 632772000506 active site clefts [active] 632772000507 zinc binding site [ion binding]; other site 632772000508 dimer interface [polypeptide binding]; other site 632772000509 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 632772000510 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 632772000511 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 632772000512 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 632772000513 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 632772000514 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 632772000515 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 632772000516 putative active site [active] 632772000517 redox center [active] 632772000518 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 632772000519 Thioredoxin; Region: Thioredoxin_4; pfam13462 632772000520 CopC domain; Region: CopC; pfam04234 632772000521 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 632772000522 Domain of unknown function (DUF305); Region: DUF305; pfam03713 632772000523 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 632772000524 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 632772000525 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 632772000526 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 632772000527 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 632772000528 catalytic residues [active] 632772000529 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 632772000530 catalytic residues [active] 632772000531 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 632772000532 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632772000533 dimerization interface [polypeptide binding]; other site 632772000534 putative DNA binding site [nucleotide binding]; other site 632772000535 putative Zn2+ binding site [ion binding]; other site 632772000536 H+ Antiporter protein; Region: 2A0121; TIGR00900 632772000537 Methyltransferase domain; Region: Methyltransf_23; pfam13489 632772000538 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772000539 S-adenosylmethionine binding site [chemical binding]; other site 632772000540 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 632772000541 Aspartase; Region: Aspartase; cd01357 632772000542 active sites [active] 632772000543 tetramer interface [polypeptide binding]; other site 632772000544 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632772000545 dimerization interface [polypeptide binding]; other site 632772000546 putative DNA binding site [nucleotide binding]; other site 632772000547 putative Zn2+ binding site [ion binding]; other site 632772000548 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 632772000549 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 632772000550 NAD(P) binding site [chemical binding]; other site 632772000551 catalytic residues [active] 632772000552 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 632772000553 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 632772000554 Walker A/P-loop; other site 632772000555 ATP binding site [chemical binding]; other site 632772000556 Q-loop/lid; other site 632772000557 ABC transporter signature motif; other site 632772000558 Walker B; other site 632772000559 D-loop; other site 632772000560 H-loop/switch region; other site 632772000561 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 632772000562 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 632772000563 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 632772000564 Walker A/P-loop; other site 632772000565 ATP binding site [chemical binding]; other site 632772000566 Q-loop/lid; other site 632772000567 ABC transporter signature motif; other site 632772000568 Walker B; other site 632772000569 D-loop; other site 632772000570 H-loop/switch region; other site 632772000571 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 632772000572 Transcriptional regulators [Transcription]; Region: GntR; COG1802 632772000573 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772000574 DNA-binding site [nucleotide binding]; DNA binding site 632772000575 FCD domain; Region: FCD; pfam07729 632772000576 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 632772000577 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772000578 dimer interface [polypeptide binding]; other site 632772000579 conserved gate region; other site 632772000580 putative PBP binding loops; other site 632772000581 ABC-ATPase subunit interface; other site 632772000582 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 632772000583 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772000584 dimer interface [polypeptide binding]; other site 632772000585 conserved gate region; other site 632772000586 putative PBP binding loops; other site 632772000587 ABC-ATPase subunit interface; other site 632772000588 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 632772000589 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 632772000590 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 632772000591 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 632772000592 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 632772000593 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 632772000594 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 632772000595 Cation efflux family; Region: Cation_efflux; cl00316 632772000596 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 632772000597 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 632772000598 Coenzyme A binding pocket [chemical binding]; other site 632772000599 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 632772000600 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 632772000601 inhibitor-cofactor binding pocket; inhibition site 632772000602 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632772000603 catalytic residue [active] 632772000604 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 632772000605 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 632772000606 tetramerization interface [polypeptide binding]; other site 632772000607 NAD(P) binding site [chemical binding]; other site 632772000608 catalytic residues [active] 632772000609 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 632772000610 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 632772000611 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 632772000612 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 632772000613 metal binding site [ion binding]; metal-binding site 632772000614 Transcriptional regulators [Transcription]; Region: GntR; COG1802 632772000615 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772000616 DNA-binding site [nucleotide binding]; DNA binding site 632772000617 FCD domain; Region: FCD; pfam07729 632772000618 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 632772000619 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 632772000620 putative hydrophobic ligand binding site [chemical binding]; other site 632772000621 CLM binding site; other site 632772000622 L1 loop; other site 632772000623 DNA binding site [nucleotide binding] 632772000624 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 632772000625 hydrophobic ligand binding site; other site 632772000626 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632772000627 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772000628 putative substrate translocation pore; other site 632772000629 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772000630 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 632772000631 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 632772000632 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 632772000633 active site residue [active] 632772000634 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632772000635 dimerization interface [polypeptide binding]; other site 632772000636 putative DNA binding site [nucleotide binding]; other site 632772000637 putative Zn2+ binding site [ion binding]; other site 632772000638 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 632772000639 active site residue [active] 632772000640 DinB superfamily; Region: DinB_2; pfam12867 632772000641 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 632772000642 Rhodanese-like domain; Region: Rhodanese; pfam00581 632772000643 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 632772000644 active site residue [active] 632772000645 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 632772000646 Domain of unknown function DUF302; Region: DUF302; pfam03625 632772000647 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 632772000648 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 632772000649 putative homotetramer interface [polypeptide binding]; other site 632772000650 putative homodimer interface [polypeptide binding]; other site 632772000651 putative allosteric switch controlling residues; other site 632772000652 putative metal binding site [ion binding]; other site 632772000653 putative homodimer-homodimer interface [polypeptide binding]; other site 632772000654 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 632772000655 active site residue [active] 632772000656 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 632772000657 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 632772000658 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 632772000659 active site residue [active] 632772000660 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 632772000661 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 632772000662 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 632772000663 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 632772000664 putative methyltransferase; Provisional; Region: PRK14967 632772000665 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772000666 S-adenosylmethionine binding site [chemical binding]; other site 632772000667 Condensation domain; Region: Condensation; pfam00668 632772000668 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772000669 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 632772000670 acyl-activating enzyme (AAE) consensus motif; other site 632772000671 AMP binding site [chemical binding]; other site 632772000672 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772000673 Condensation domain; Region: Condensation; pfam00668 632772000674 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 632772000675 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772000676 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 632772000677 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 632772000678 dimerization interface [polypeptide binding]; other site 632772000679 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 632772000680 dimer interface [polypeptide binding]; other site 632772000681 phosphorylation site [posttranslational modification] 632772000682 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632772000683 ATP binding site [chemical binding]; other site 632772000684 Mg2+ binding site [ion binding]; other site 632772000685 G-X-G motif; other site 632772000686 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 632772000687 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632772000688 active site 632772000689 phosphorylation site [posttranslational modification] 632772000690 intermolecular recognition site; other site 632772000691 dimerization interface [polypeptide binding]; other site 632772000692 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 632772000693 DNA binding site [nucleotide binding] 632772000694 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 632772000695 DNA binding residues [nucleotide binding] 632772000696 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 632772000697 hypothetical protein; Provisional; Region: PRK02237 632772000698 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772000699 active site 632772000700 Transposase; Region: DEDD_Tnp_IS110; pfam01548 632772000701 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 632772000702 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 632772000703 Resolvase, N terminal domain; Region: Resolvase; pfam00239 632772000704 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 632772000705 catalytic residues [active] 632772000706 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 632772000707 DNA-binding interface [nucleotide binding]; DNA binding site 632772000708 potential frameshift: common BLAST hit: gi|111017138|ref|YP_700110.1| resolvase, N-terminal 632772000709 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 632772000710 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 632772000711 catalytic nucleophile [active] 632772000712 Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: CysS; COG0215 632772000713 putative acetyltransferase; Provisional; Region: PRK03624 632772000714 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 632772000715 Coenzyme A binding pocket [chemical binding]; other site 632772000716 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 632772000717 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632772000718 Walker A motif; other site 632772000719 ATP binding site [chemical binding]; other site 632772000720 Walker B motif; other site 632772000721 arginine finger; other site 632772000722 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 632772000723 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 632772000724 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 632772000725 MarR family; Region: MarR_2; pfam12802 632772000726 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 632772000727 Integrase core domain; Region: rve_3; pfam13683 632772000728 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 632772000729 Helix-turn-helix domain; Region: HTH_38; pfam13936 632772000730 Integrase core domain; Region: rve; pfam00665 632772000731 HTH-like domain; Region: HTH_21; pfam13276 632772000732 Integrase core domain; Region: rve; pfam00665 632772000733 Transposase; Region: HTH_Tnp_1; cl17663 632772000734 rod shape-determining protein MreC; Provisional; Region: PRK13922 632772000735 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 632772000736 N-acetyl-D-glucosamine binding site [chemical binding]; other site 632772000737 catalytic residue [active] 632772000738 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 632772000739 NlpC/P60 family; Region: NLPC_P60; pfam00877 632772000740 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 632772000741 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 632772000742 Walker A/P-loop; other site 632772000743 ATP binding site [chemical binding]; other site 632772000744 Q-loop/lid; other site 632772000745 ABC transporter signature motif; other site 632772000746 Walker B; other site 632772000747 D-loop; other site 632772000748 H-loop/switch region; other site 632772000749 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 632772000750 mce related protein; Region: MCE; pfam02470 632772000751 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 632772000752 mce related protein; Region: MCE; pfam02470 632772000753 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 632772000754 mce related protein; Region: MCE; pfam02470 632772000755 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 632772000756 mce related protein; Region: MCE; pfam02470 632772000757 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 632772000758 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 632772000759 mce related protein; Region: MCE; pfam02470 632772000760 mce related protein; Region: MCE; pfam02470 632772000761 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 632772000762 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 632772000763 Permease; Region: Permease; pfam02405 632772000764 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 632772000765 Permease; Region: Permease; pfam02405 632772000766 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 632772000767 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 632772000768 dimer interface [polypeptide binding]; other site 632772000769 acyl-activating enzyme (AAE) consensus motif; other site 632772000770 putative active site [active] 632772000771 AMP binding site [chemical binding]; other site 632772000772 putative CoA binding site [chemical binding]; other site 632772000773 SCP-2 sterol transfer family; Region: SCP2; pfam02036 632772000774 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 632772000775 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 632772000776 NAD(P) binding site [chemical binding]; other site 632772000777 catalytic residues [active] 632772000778 4Fe-4S binding domain; Region: Fer4; cl02805 632772000779 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 632772000780 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 632772000781 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 632772000782 active site 632772000783 diiron metal binding site [ion binding]; other site 632772000784 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 632772000785 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 632772000786 NAD binding site [chemical binding]; other site 632772000787 catalytic Zn binding site [ion binding]; other site 632772000788 substrate binding site [chemical binding]; other site 632772000789 structural Zn binding site [ion binding]; other site 632772000790 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 632772000791 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 632772000792 dimer interface [polypeptide binding]; other site 632772000793 phosphorylation site [posttranslational modification] 632772000794 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632772000795 ATP binding site [chemical binding]; other site 632772000796 Mg2+ binding site [ion binding]; other site 632772000797 G-X-G motif; other site 632772000798 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632772000799 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632772000800 active site 632772000801 phosphorylation site [posttranslational modification] 632772000802 intermolecular recognition site; other site 632772000803 dimerization interface [polypeptide binding]; other site 632772000804 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 632772000805 dimerization interface [polypeptide binding]; other site 632772000806 DNA binding residues [nucleotide binding] 632772000807 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 632772000808 Catalytic domain of Protein Kinases; Region: PKc; cd00180 632772000809 active site 632772000810 ATP binding site [chemical binding]; other site 632772000811 substrate binding site [chemical binding]; other site 632772000812 activation loop (A-loop); other site 632772000813 AAA ATPase domain; Region: AAA_16; pfam13191 632772000814 AAA domain; Region: AAA_22; pfam13401 632772000815 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632772000816 ABC transporter signature motif; other site 632772000817 Walker B; other site 632772000818 D-loop; other site 632772000819 H-loop/switch region; other site 632772000820 Homeodomain-like domain; Region: HTH_23; pfam13384 632772000821 Winged helix-turn helix; Region: HTH_29; pfam13551 632772000822 Homeodomain-like domain; Region: HTH_32; pfam13565 632772000823 DDE superfamily endonuclease; Region: DDE_3; pfam13358 632772000824 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 632772000825 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772000826 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772000827 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 632772000828 CoenzymeA binding site [chemical binding]; other site 632772000829 subunit interaction site [polypeptide binding]; other site 632772000830 PHB binding site; other site 632772000831 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 632772000832 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 632772000833 Cytochrome P450; Region: p450; cl12078 632772000834 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 632772000835 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 632772000836 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 632772000837 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 632772000838 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 632772000839 Cytochrome P450; Region: p450; cl12078 632772000840 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 632772000841 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772000842 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772000843 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772000844 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 632772000845 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 632772000846 CoenzymeA binding site [chemical binding]; other site 632772000847 subunit interaction site [polypeptide binding]; other site 632772000848 PHB binding site; other site 632772000849 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 632772000850 cyclase homology domain; Region: CHD; cd07302 632772000851 dimer interface [polypeptide binding]; other site 632772000852 metal binding site [ion binding]; metal-binding site 632772000853 ANTAR domain; Region: ANTAR; pfam03861 632772000854 putative transposase OrfB; Reviewed; Region: PHA02517 632772000855 HTH-like domain; Region: HTH_21; pfam13276 632772000856 Integrase core domain; Region: rve; pfam00665 632772000857 Integrase core domain; Region: rve_3; pfam13683 632772000858 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 632772000859 Transposase; Region: HTH_Tnp_1; cl17663 632772000860 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 632772000861 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 632772000862 Fatty acid desaturase; Region: FA_desaturase; pfam00487 632772000863 Di-iron ligands [ion binding]; other site 632772000864 Rubredoxin [Energy production and conversion]; Region: COG1773 632772000865 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 632772000866 iron binding site [ion binding]; other site 632772000867 Rubredoxin [Energy production and conversion]; Region: COG1773 632772000868 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 632772000869 iron binding site [ion binding]; other site 632772000870 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 632772000871 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 632772000872 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772000873 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772000874 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 632772000875 putative active site; other site 632772000876 putative metal binding residues [ion binding]; other site 632772000877 signature motif; other site 632772000878 putative triphosphate binding site [ion binding]; other site 632772000879 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 632772000880 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 632772000881 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 632772000882 DNA binding site [nucleotide binding] 632772000883 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 632772000884 MarR family; Region: MarR_2; pfam12802 632772000885 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772000886 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 632772000887 acyl-activating enzyme (AAE) consensus motif; other site 632772000888 AMP binding site [chemical binding]; other site 632772000889 active site 632772000890 CoA binding site [chemical binding]; other site 632772000891 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772000892 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 632772000893 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 632772000894 putative trimer interface [polypeptide binding]; other site 632772000895 putative CoA binding site [chemical binding]; other site 632772000896 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 632772000897 putative trimer interface [polypeptide binding]; other site 632772000898 putative CoA binding site [chemical binding]; other site 632772000899 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 632772000900 catalytic core [active] 632772000901 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 632772000902 PhoU domain; Region: PhoU; pfam01895 632772000903 PhoU domain; Region: PhoU; pfam01895 632772000904 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 632772000905 Helicase associated domain; Region: HA; pfam03457 632772000906 Helicase associated domain; Region: HA; pfam03457 632772000907 Helicase associated domain; Region: HA; pfam03457 632772000908 Helicase associated domain; Region: HA; pfam03457 632772000909 Helicase associated domain; Region: HA; pfam03457 632772000910 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 632772000911 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 632772000912 DNA binding site [nucleotide binding] 632772000913 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 632772000914 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 632772000915 Walker A/P-loop; other site 632772000916 ATP binding site [chemical binding]; other site 632772000917 Q-loop/lid; other site 632772000918 ABC transporter signature motif; other site 632772000919 Walker B; other site 632772000920 D-loop; other site 632772000921 H-loop/switch region; other site 632772000922 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 632772000923 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772000924 ABC-ATPase subunit interface; other site 632772000925 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 632772000926 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772000927 dimer interface [polypeptide binding]; other site 632772000928 conserved gate region; other site 632772000929 putative PBP binding loops; other site 632772000930 ABC-ATPase subunit interface; other site 632772000931 PBP superfamily domain; Region: PBP_like_2; cl17296 632772000932 Ion channel; Region: Ion_trans_2; pfam07885 632772000933 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 632772000934 TrkA-N domain; Region: TrkA_N; pfam02254 632772000935 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 632772000936 DNA binding site [nucleotide binding] 632772000937 Int/Topo IB signature motif; other site 632772000938 active site 632772000939 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 632772000940 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 632772000941 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 632772000942 active site 632772000943 catalytic residues [active] 632772000944 DNA binding site [nucleotide binding] 632772000945 Int/Topo IB signature motif; other site 632772000946 putative transposase OrfB; Reviewed; Region: PHA02517 632772000947 HTH-like domain; Region: HTH_21; pfam13276 632772000948 Integrase core domain; Region: rve; pfam00665 632772000949 Integrase core domain; Region: rve_3; cl15866 632772000950 Transposase; Region: HTH_Tnp_1; cl17663 632772000951 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 632772000952 active site 632772000953 catalytic residues [active] 632772000954 DNA binding site [nucleotide binding] 632772000955 Int/Topo IB signature motif; other site 632772000956 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 632772000957 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 632772000958 catalytic nucleophile [active] 632772000959 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 632772000960 multiple promoter invertase; Provisional; Region: mpi; PRK13413 632772000961 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 632772000962 catalytic residues [active] 632772000963 catalytic nucleophile [active] 632772000964 Presynaptic Site I dimer interface [polypeptide binding]; other site 632772000965 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 632772000966 Synaptic Flat tetramer interface [polypeptide binding]; other site 632772000967 Synaptic Site I dimer interface [polypeptide binding]; other site 632772000968 DNA binding site [nucleotide binding] 632772000969 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 632772000970 DNA-binding interface [nucleotide binding]; DNA binding site 632772000971 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 632772000972 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 632772000973 active site 632772000974 catalytic residues [active] 632772000975 DNA binding site [nucleotide binding] 632772000976 Int/Topo IB signature motif; other site 632772000977 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 632772000978 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 632772000979 active site 632772000980 Int/Topo IB signature motif; other site 632772000981 DNA binding site [nucleotide binding] 632772000982 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 632772000983 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 632772000984 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 632772000985 DNA binding site [nucleotide binding] 632772000986 Gas vesicle protein; Region: Gas_vesicle; cl02954 632772000987 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 632772000988 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 632772000989 non-specific DNA binding site [nucleotide binding]; other site 632772000990 salt bridge; other site 632772000991 sequence-specific DNA binding site [nucleotide binding]; other site 632772000992 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772000993 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 632772000994 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 632772000995 CoA-transferase family III; Region: CoA_transf_3; pfam02515 632772000996 Transcriptional regulator [Transcription]; Region: LysR; COG0583 632772000997 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 632772000998 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 632772000999 putative dimerization interface [polypeptide binding]; other site 632772001000 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 632772001001 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 632772001002 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 632772001003 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 632772001004 Transcriptional regulator [Transcription]; Region: LysR; COG0583 632772001005 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 632772001006 putative dimerization interface [polypeptide binding]; other site 632772001007 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 632772001008 TIGR03086 family protein; Region: TIGR03086 632772001009 Integrase core domain; Region: rve_3; pfam13683 632772001010 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 632772001011 Helix-turn-helix domain; Region: HTH_38; pfam13936 632772001012 Integrase core domain; Region: rve; pfam00665 632772001013 Integrase core domain; Region: rve; pfam00665 632772001014 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 632772001015 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 632772001016 active site 632772001017 catalytic residues [active] 632772001018 DNA binding site [nucleotide binding] 632772001019 Int/Topo IB signature motif; other site 632772001020 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 632772001021 active site 632772001022 catalytic residues [active] 632772001023 DNA binding site [nucleotide binding] 632772001024 Int/Topo IB signature motif; other site 632772001025 HTH-like domain; Region: HTH_21; pfam13276 632772001026 Transposase; Region: HTH_Tnp_1; cl17663 632772001027 Lsr2; Region: Lsr2; pfam11774 632772001028 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 632772001029 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 632772001030 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 632772001031 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 632772001032 Helix-turn-helix domain; Region: HTH_38; pfam13936 632772001033 Integrase core domain; Region: rve; pfam00665 632772001034 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 632772001035 active site 632772001036 catalytic residues [active] 632772001037 DNA binding site [nucleotide binding] 632772001038 Int/Topo IB signature motif; other site 632772001039 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 632772001040 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 632772001041 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 632772001042 active site 632772001043 catalytic residues [active] 632772001044 DNA binding site [nucleotide binding] 632772001045 Int/Topo IB signature motif; other site 632772001046 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 632772001047 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 632772001048 Cytochrome P450; Region: p450; cl12078 632772001049 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 632772001050 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 632772001051 active site 632772001052 catalytic site [active] 632772001053 substrate binding site [chemical binding]; other site 632772001054 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 632772001055 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 632772001056 active site 632772001057 DNA binding site [nucleotide binding] 632772001058 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 632772001059 DNA binding site [nucleotide binding] 632772001060 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 632772001061 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 632772001062 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772001063 S-adenosylmethionine binding site [chemical binding]; other site 632772001064 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 632772001065 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 632772001066 catalytic residues [active] 632772001067 catalytic nucleophile [active] 632772001068 Presynaptic Site I dimer interface [polypeptide binding]; other site 632772001069 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 632772001070 Synaptic Flat tetramer interface [polypeptide binding]; other site 632772001071 Synaptic Site I dimer interface [polypeptide binding]; other site 632772001072 DNA binding site [nucleotide binding] 632772001073 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 632772001074 Protein of unknown function (DUF1188); Region: DUF1188; cl01642 632772001075 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 632772001076 Lsr2; Region: Lsr2; pfam11774 632772001077 Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117 632772001078 homodimer interface [polypeptide binding]; other site 632772001079 putative active site [active] 632772001080 catalytic site [active] 632772001081 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 632772001082 YCII-related domain; Region: YCII; cl00999 632772001083 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 632772001084 Active Sites [active] 632772001085 CRISPR/Cas system-associated RAMP superfamily protein Csf2; Region: Csf2_U; cl11864 632772001086 CRISPR/Cas system-associated RAMP superfamily protein Csf3; Region: Csf3_U; cl11865 632772001087 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 632772001088 LGFP repeat; Region: LGFP; pfam08310 632772001089 LGFP repeat; Region: LGFP; pfam08310 632772001090 Domain of unknown function (DUF955); Region: DUF955; pfam06114 632772001091 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 632772001092 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 632772001093 salt bridge; other site 632772001094 non-specific DNA binding site [nucleotide binding]; other site 632772001095 sequence-specific DNA binding site [nucleotide binding]; other site 632772001096 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 632772001097 LGFP repeat; Region: LGFP; pfam08310 632772001098 LGFP repeat; Region: LGFP; pfam08310 632772001099 LGFP repeat; Region: LGFP; pfam08310 632772001100 LGFP repeat; Region: LGFP; pfam08310 632772001101 Peptidase family M48; Region: Peptidase_M48; pfam01435 632772001102 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 632772001103 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 632772001104 LGFP repeat; Region: LGFP; pfam08310 632772001105 LGFP repeat; Region: LGFP; pfam08310 632772001106 Restriction endonuclease; Region: Mrr_cat; pfam04471 632772001107 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 632772001108 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 632772001109 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 632772001110 Coenzyme A binding pocket [chemical binding]; other site 632772001111 Domain of unknown function (DUF3846); Region: DUF3846; pfam12957 632772001112 Clp amino terminal domain; Region: Clp_N; pfam02861 632772001113 Uncharacterized conserved protein [Function unknown]; Region: COG4938 632772001114 Protein of unknown function (DUF3696); Region: DUF3696; pfam12476 632772001115 Uncharacterized conserved protein [Function unknown]; Region: COG1479 632772001116 Protein of unknown function DUF262; Region: DUF262; pfam03235 632772001117 Protein of unknown function DUF262; Region: DUF262; pfam03235 632772001118 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 632772001119 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 632772001120 cofactor binding site; other site 632772001121 DNA binding site [nucleotide binding] 632772001122 substrate interaction site [chemical binding]; other site 632772001123 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 632772001124 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 632772001125 active site 632772001126 Restriction endonuclease NaeI; Region: NaeI; pfam09126 632772001127 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 632772001128 additional DNA contacts [nucleotide binding]; other site 632772001129 mismatch recognition site; other site 632772001130 active site 632772001131 zinc binding site [ion binding]; other site 632772001132 DNA intercalation site [nucleotide binding]; other site 632772001133 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 632772001134 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 632772001135 ATP-binding site [chemical binding]; other site 632772001136 Nuclease-related domain; Region: NERD; pfam08378 632772001137 PhoH-like protein; Region: PhoH; cl17668 632772001138 DEAD-like helicases superfamily; Region: DEXDc; smart00487 632772001139 Family description; Region: UvrD_C_2; pfam13538 632772001140 Domain of unknown function (DUF4268); Region: DUF4268; pfam14088 632772001141 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 632772001142 AAA domain; Region: AAA_31; pfam13614 632772001143 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 632772001144 P-loop; other site 632772001145 Magnesium ion binding site [ion binding]; other site 632772001146 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632772001147 Walker A motif; other site 632772001148 ATP binding site [chemical binding]; other site 632772001149 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632772001150 Walker A motif; other site 632772001151 ATP binding site [chemical binding]; other site 632772001152 AAA-like domain; Region: AAA_10; pfam12846 632772001153 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 632772001154 Peptidase family M23; Region: Peptidase_M23; pfam01551 632772001155 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 632772001156 N-acetyl-D-glucosamine binding site [chemical binding]; other site 632772001157 catalytic residue [active] 632772001158 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 632772001159 NlpC/P60 family; Region: NLPC_P60; pfam00877 632772001160 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 632772001161 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 632772001162 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 632772001163 Probable transposase; Region: OrfB_IS605; pfam01385 632772001164 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 632772001165 Cytochrome P450; Region: p450; cl12078 632772001166 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 632772001167 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 632772001168 ent-kaurene oxidase; Region: PLN02655 632772001169 Intracellular septation protein A; Region: IspA; pfam04279 632772001170 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 632772001171 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 632772001172 non-specific DNA binding site [nucleotide binding]; other site 632772001173 salt bridge; other site 632772001174 sequence-specific DNA binding site [nucleotide binding]; other site 632772001175 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 632772001176 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 632772001177 salt bridge; other site 632772001178 non-specific DNA binding site [nucleotide binding]; other site 632772001179 sequence-specific DNA binding site [nucleotide binding]; other site 632772001180 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 632772001181 Transposase; Region: DEDD_Tnp_IS110; pfam01548 632772001182 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 632772001183 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 632772001184 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 632772001185 P-loop; other site 632772001186 Magnesium ion binding site [ion binding]; other site 632772001187 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 632772001188 Magnesium ion binding site [ion binding]; other site 632772001189 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 632772001190 Lsr2; Region: Lsr2; pfam11774 632772001191 Integrase core domain; Region: rve; pfam00665 632772001192 Integrase core domain; Region: rve_3; pfam13683 632772001193 Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117 632772001194 PLD-like domain; Region: PLDc_2; pfam13091 632772001195 homodimer interface [polypeptide binding]; other site 632772001196 putative active site [active] 632772001197 catalytic site [active] 632772001198 Cutinase; Region: Cutinase; pfam01083 632772001199 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772001200 metabolite-proton symporter; Region: 2A0106; TIGR00883 632772001201 putative substrate translocation pore; other site 632772001202 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 632772001203 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 632772001204 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 632772001205 pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188 632772001206 Int/Topo IB signature motif; other site 632772001207 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 632772001208 active site 632772001209 DNA binding site [nucleotide binding] 632772001210 Int/Topo IB signature motif; other site 632772001211 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 632772001212 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 632772001213 active site 632772001214 DNA binding site [nucleotide binding] 632772001215 Int/Topo IB signature motif; other site 632772001216 transposase/IS protein; Provisional; Region: PRK09183 632772001217 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632772001218 Walker A motif; other site 632772001219 ATP binding site [chemical binding]; other site 632772001220 Walker B motif; other site 632772001221 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 632772001222 Helix-turn-helix domain; Region: HTH_38; pfam13936 632772001223 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 632772001224 Transposase; Region: DDE_Tnp_ISL3; pfam01610 632772001225 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 632772001226 Transposase; Region: DDE_Tnp_ISL3; pfam01610 632772001227 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 632772001228 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 632772001229 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 632772001230 putative active site [active] 632772001231 putative NTP binding site [chemical binding]; other site 632772001232 putative nucleic acid binding site [nucleotide binding]; other site 632772001233 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 632772001234 Integrase core domain; Region: rve; pfam00665 632772001235 Integrase core domain; Region: rve_3; pfam13683 632772001236 potential frameshift: common BLAST hit: gi|111025377|ref|YP_707797.1| transposase 632772001237 MULE transposase domain; Region: MULE; pfam10551 632772001238 MULE transposase domain; Region: MULE; pfam10551 632772001239 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 632772001240 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 632772001241 FMN-binding pocket [chemical binding]; other site 632772001242 flavin binding motif; other site 632772001243 phosphate binding motif [ion binding]; other site 632772001244 beta-alpha-beta structure motif; other site 632772001245 NAD binding pocket [chemical binding]; other site 632772001246 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 632772001247 catalytic loop [active] 632772001248 iron binding site [ion binding]; other site 632772001249 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 632772001250 putative active site [active] 632772001251 ATP binding site [chemical binding]; other site 632772001252 putative substrate binding site [chemical binding]; other site 632772001253 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 632772001254 classical (c) SDRs; Region: SDR_c; cd05233 632772001255 NAD(P) binding site [chemical binding]; other site 632772001256 active site 632772001257 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 632772001258 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772001259 substrate binding site [chemical binding]; other site 632772001260 oxyanion hole (OAH) forming residues; other site 632772001261 trimer interface [polypeptide binding]; other site 632772001262 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 632772001263 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772001264 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 632772001265 acyl-activating enzyme (AAE) consensus motif; other site 632772001266 acyl-activating enzyme (AAE) consensus motif; other site 632772001267 putative AMP binding site [chemical binding]; other site 632772001268 putative active site [active] 632772001269 putative CoA binding site [chemical binding]; other site 632772001270 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 632772001271 Cytochrome P450; Region: p450; cl12078 632772001272 Cupin domain; Region: Cupin_2; cl17218 632772001273 short chain dehydrogenase; Provisional; Region: PRK06172 632772001274 classical (c) SDRs; Region: SDR_c; cd05233 632772001275 NAD(P) binding site [chemical binding]; other site 632772001276 active site 632772001277 glutathione S-transferase; Provisional; Region: PRK15113 632772001278 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 632772001279 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 632772001280 dimer interface [polypeptide binding]; other site 632772001281 active site 632772001282 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772001283 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772001284 active site 632772001285 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 632772001286 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 632772001287 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 632772001288 CoA-transferase family III; Region: CoA_transf_3; pfam02515 632772001289 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 632772001290 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 632772001291 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 632772001292 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 632772001293 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 632772001294 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 632772001295 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 632772001296 active site 632772001297 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 632772001298 cyclase homology domain; Region: CHD; cd07302 632772001299 nucleotidyl binding site; other site 632772001300 metal binding site [ion binding]; metal-binding site 632772001301 dimer interface [polypeptide binding]; other site 632772001302 enoyl-CoA hydratase; Provisional; Region: PRK07509 632772001303 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772001304 substrate binding site [chemical binding]; other site 632772001305 oxyanion hole (OAH) forming residues; other site 632772001306 trimer interface [polypeptide binding]; other site 632772001307 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 632772001308 CoA-transferase family III; Region: CoA_transf_3; pfam02515 632772001309 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 632772001310 Transcriptional regulators [Transcription]; Region: FadR; COG2186 632772001311 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772001312 DNA-binding site [nucleotide binding]; DNA binding site 632772001313 FCD domain; Region: FCD; pfam07729 632772001314 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 632772001315 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 632772001316 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 632772001317 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 632772001318 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 632772001319 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 632772001320 Cytochrome P450; Region: p450; cl12078 632772001321 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 632772001322 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 632772001323 NAD(P) binding site [chemical binding]; other site 632772001324 catalytic residues [active] 632772001325 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 632772001326 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 632772001327 NAD binding site [chemical binding]; other site 632772001328 catalytic Zn binding site [ion binding]; other site 632772001329 substrate binding site [chemical binding]; other site 632772001330 structural Zn binding site [ion binding]; other site 632772001331 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 632772001332 CoA binding domain; Region: CoA_binding_2; pfam13380 632772001333 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 632772001334 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 632772001335 Ecdysteroid kinase; Region: EcKinase; cl17738 632772001336 Phosphotransferase enzyme family; Region: APH; pfam01636 632772001337 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 632772001338 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 632772001339 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 632772001340 Phosphotransferase enzyme family; Region: APH; pfam01636 632772001341 Ecdysteroid kinase; Region: EcKinase; cl17738 632772001342 potential frameshift: common BLAST hit: gi|111025791|ref|YP_708211.1| transposase 632772001343 Winged helix-turn helix; Region: HTH_29; pfam13551 632772001344 Homeodomain-like domain; Region: HTH_23; pfam13384 632772001345 Homeodomain-like domain; Region: HTH_32; pfam13565 632772001346 DDE superfamily endonuclease; Region: DDE_3; pfam13358 632772001347 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 632772001348 Amino acid permease; Region: AA_permease_2; pfam13520 632772001349 hypothetical protein; Provisional; Region: PRK06541 632772001350 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 632772001351 inhibitor-cofactor binding pocket; inhibition site 632772001352 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632772001353 catalytic residue [active] 632772001354 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 632772001355 classical (c) SDRs; Region: SDR_c; cd05233 632772001356 NAD(P) binding site [chemical binding]; other site 632772001357 active site 632772001358 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 632772001359 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772001360 substrate binding site [chemical binding]; other site 632772001361 oxyanion hole (OAH) forming residues; other site 632772001362 trimer interface [polypeptide binding]; other site 632772001363 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 632772001364 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772001365 acyl-activating enzyme (AAE) consensus motif; other site 632772001366 AMP binding site [chemical binding]; other site 632772001367 active site 632772001368 CoA binding site [chemical binding]; other site 632772001369 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772001370 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772001371 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 632772001372 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 632772001373 NAD(P) binding site [chemical binding]; other site 632772001374 catalytic residues [active] 632772001375 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 632772001376 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 632772001377 dimer interface [polypeptide binding]; other site 632772001378 active site 632772001379 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 632772001380 putative FMN binding site [chemical binding]; other site 632772001381 EthD domain; Region: EthD; pfam07110 632772001382 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 632772001383 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 632772001384 active site 632772001385 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772001386 metabolite-proton symporter; Region: 2A0106; TIGR00883 632772001387 putative substrate translocation pore; other site 632772001388 Coenzyme A transferase; Region: CoA_trans; smart00882 632772001389 Coenzyme A transferase; Region: CoA_trans; cl17247 632772001390 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 632772001391 CoA-transferase family III; Region: CoA_transf_3; pfam02515 632772001392 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 632772001393 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 632772001394 CoA-transferase family III; Region: CoA_transf_3; pfam02515 632772001395 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 632772001396 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772001397 substrate binding site [chemical binding]; other site 632772001398 oxyanion hole (OAH) forming residues; other site 632772001399 trimer interface [polypeptide binding]; other site 632772001400 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 632772001401 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 632772001402 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 632772001403 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 632772001404 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 632772001405 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 632772001406 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772001407 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 632772001408 substrate binding site [chemical binding]; other site 632772001409 oxyanion hole (OAH) forming residues; other site 632772001410 trimer interface [polypeptide binding]; other site 632772001411 Transcriptional regulator [Transcription]; Region: IclR; COG1414 632772001412 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632772001413 putative DNA binding site [nucleotide binding]; other site 632772001414 putative Zn2+ binding site [ion binding]; other site 632772001415 Bacterial transcriptional regulator; Region: IclR; pfam01614 632772001416 DDE superfamily endonuclease; Region: DDE_5; cl17874 632772001417 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 632772001418 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 632772001419 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 632772001420 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 632772001421 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 632772001422 Rieske non-heme iron oxygenase (RO) family, Biphenyl dioxygenase (BPDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of BPDO and similar proteins including cumene dioxygenase (CumDO); Region: Rieske_RO_Alpha_BPDO_like; cd03472 632772001423 beta subunit interaction site [polypeptide binding]; other site 632772001424 alpha subunit interaction site [polypeptide binding]; other site 632772001425 iron-sulfur cluster [ion binding]; other site 632772001426 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 632772001427 beta subunit interface [polypeptide binding]; other site 632772001428 alpha subunit interface [polypeptide binding]; other site 632772001429 active site 632772001430 substrate binding site [chemical binding]; other site 632772001431 Fe binding site [ion binding]; other site 632772001432 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 632772001433 inter-subunit interface; other site 632772001434 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 632772001435 [2Fe-2S] cluster binding site [ion binding]; other site 632772001436 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 632772001437 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 632772001438 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 632772001439 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 632772001440 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 632772001441 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 632772001442 active site 632772001443 Fe binding site [ion binding]; other site 632772001444 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 632772001445 cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase (BphB)-like, classical (c) SDRs; Region: BphB-like_SDR_c; cd05348 632772001446 NAD binding site [chemical binding]; other site 632772001447 active site 632772001448 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 632772001449 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 632772001450 active site 632772001451 ATP binding site [chemical binding]; other site 632772001452 substrate binding site [chemical binding]; other site 632772001453 activation loop (A-loop); other site 632772001454 AAA ATPase domain; Region: AAA_16; pfam13191 632772001455 Tetratricopeptide repeat; Region: TPR_12; pfam13424 632772001456 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 632772001457 Histidine kinase; Region: HisKA_3; pfam07730 632772001458 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632772001459 ATP binding site [chemical binding]; other site 632772001460 Mg2+ binding site [ion binding]; other site 632772001461 G-X-G motif; other site 632772001462 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632772001463 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632772001464 active site 632772001465 phosphorylation site [posttranslational modification] 632772001466 intermolecular recognition site; other site 632772001467 dimerization interface [polypeptide binding]; other site 632772001468 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632772001469 DNA binding residues [nucleotide binding] 632772001470 dimerization interface [polypeptide binding]; other site 632772001471 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 632772001472 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 632772001473 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 632772001474 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772001475 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 632772001476 acyl-activating enzyme (AAE) consensus motif; other site 632772001477 AMP binding site [chemical binding]; other site 632772001478 active site 632772001479 CoA binding site [chemical binding]; other site 632772001480 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 632772001481 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772001482 substrate binding site [chemical binding]; other site 632772001483 oxyanion hole (OAH) forming residues; other site 632772001484 trimer interface [polypeptide binding]; other site 632772001485 haloalkane dehalogenase; Provisional; Region: PRK03592 632772001486 Domain of unknown function (DUF427); Region: DUF427; pfam04248 632772001487 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 632772001488 potential frameshift: common BLAST hit: gi|145225215|ref|YP_001135893.1| transposase, mutator type 632772001489 Transposase, Mutator family; Region: Transposase_mut; pfam00872 632772001490 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 632772001491 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 632772001492 NAD(P) binding site [chemical binding]; other site 632772001493 Transposase, Mutator family; Region: Transposase_mut; pfam00872 632772001494 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 632772001495 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 632772001496 DDE superfamily endonuclease; Region: DDE_5; cl17874 632772001497 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 632772001498 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 632772001499 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 632772001500 active site 632772001501 metal binding site [ion binding]; metal-binding site 632772001502 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 632772001503 C-terminal domain of type I, class II extradiol dioxygenases; catalytic domain; Region: ED_TypeI_classII_C; cd08343 632772001504 active site 632772001505 metal binding site [ion binding]; metal-binding site 632772001506 Cupin domain; Region: Cupin_2; pfam07883 632772001507 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 632772001508 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772001509 NAD(P) binding site [chemical binding]; other site 632772001510 active site 632772001511 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 632772001512 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772001513 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 632772001514 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 632772001515 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 632772001516 Transcriptional regulators [Transcription]; Region: FadR; COG2186 632772001517 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772001518 DNA-binding site [nucleotide binding]; DNA binding site 632772001519 FCD domain; Region: FCD; pfam07729 632772001520 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 632772001521 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365 632772001522 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 632772001523 putative active site [active] 632772001524 Fe(II) binding site [ion binding]; other site 632772001525 putative dimer interface [polypeptide binding]; other site 632772001526 putative tetramer interface [polypeptide binding]; other site 632772001527 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 632772001528 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 632772001529 acetaldehyde dehydrogenase; Validated; Region: PRK08300 632772001530 potential frameshift: common BLAST hit: gi|111026180|ref|YP_708463.1| 4-hydroxy-2-ketovalerate aldolase 632772001531 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 632772001532 metal binding site [ion binding]; metal-binding site 632772001533 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 632772001534 DmpG-like communication domain; Region: DmpG_comm; pfam07836 632772001535 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 632772001536 Ligand binding site [chemical binding]; other site 632772001537 Electron transfer flavoprotein domain; Region: ETF; pfam01012 632772001538 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 632772001539 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 632772001540 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 632772001541 Rubredoxin; Region: Rubredoxin; pfam00301 632772001542 iron binding site [ion binding]; other site 632772001543 Transcriptional regulators [Transcription]; Region: GntR; COG1802 632772001544 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772001545 DNA-binding site [nucleotide binding]; DNA binding site 632772001546 FCD domain; Region: FCD; pfam07729 632772001547 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 632772001548 SCP-2 sterol transfer family; Region: SCP2; pfam02036 632772001549 Rieske non-heme iron oxygenase (RO) family, Nathphalene 1,2-dioxygenase (NDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_NDO; cd03535 632772001550 alpha subunit interaction site [polypeptide binding]; other site 632772001551 beta subunit interaction site [polypeptide binding]; other site 632772001552 iron-sulfur cluster [ion binding]; other site 632772001553 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 632772001554 beta subunit interface [polypeptide binding]; other site 632772001555 alpha subunit interface [polypeptide binding]; other site 632772001556 active site 632772001557 substrate binding site [chemical binding]; other site 632772001558 Fe binding site [ion binding]; other site 632772001559 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 632772001560 inter-subunit interface; other site 632772001561 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 632772001562 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772001563 NAD(P) binding site [chemical binding]; other site 632772001564 active site 632772001565 Trans-o-hydroxybenzylidenepyruvate hydratase-aldolase (HBPHA) and trans-2'-carboxybenzalpyruvate hydratase-aldolase (CBPHA); Region: CHBPH_aldolase; cd00952 632772001566 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 632772001567 putative active site [active] 632772001568 catalytic residue [active] 632772001569 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 632772001570 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 632772001571 active site 632772001572 Int/Topo IB signature motif; other site 632772001573 Transcriptional regulators [Transcription]; Region: FadR; COG2186 632772001574 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772001575 DNA-binding site [nucleotide binding]; DNA binding site 632772001576 FCD domain; Region: FCD; pfam07729 632772001577 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 632772001578 FAD binding domain; Region: FAD_binding_4; pfam01565 632772001579 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 632772001580 Cysteine-rich domain; Region: CCG; pfam02754 632772001581 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 632772001582 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 632772001583 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 632772001584 active site 632772001585 catalytic residues [active] 632772001586 metal binding site [ion binding]; metal-binding site 632772001587 DmpG-like communication domain; Region: DmpG_comm; pfam07836 632772001588 acetaldehyde dehydrogenase; Validated; Region: PRK08300 632772001589 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 632772001590 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 632772001591 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 632772001592 Transcriptional regulator [Transcription]; Region: IclR; COG1414 632772001593 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 632772001594 Bacterial transcriptional regulator; Region: IclR; pfam01614 632772001595 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 632772001596 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632772001597 DNA binding residues [nucleotide binding] 632772001598 This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins; Region: LNS2; smart00775 632772001599 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 632772001600 Zeta toxin; Region: Zeta_toxin; pfam06414 632772001601 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 632772001602 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 632772001603 active site 632772001604 NTP binding site [chemical binding]; other site 632772001605 metal binding triad [ion binding]; metal-binding site 632772001606 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 632772001607 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 632772001608 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 632772001609 DNA binding residues [nucleotide binding] 632772001610 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 632772001611 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 632772001612 Clp amino terminal domain; Region: Clp_N; pfam02861 632772001613 HicB family; Region: HicB; pfam05534 632772001614 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 632772001615 active site 632772001616 NTP binding site [chemical binding]; other site 632772001617 metal binding triad [ion binding]; metal-binding site 632772001618 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 632772001619 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632772001620 dimerization interface [polypeptide binding]; other site 632772001621 putative DNA binding site [nucleotide binding]; other site 632772001622 putative Zn2+ binding site [ion binding]; other site 632772001623 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 632772001624 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 632772001625 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 632772001626 Coenzyme A binding pocket [chemical binding]; other site 632772001627 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 632772001628 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 632772001629 DNA binding residues [nucleotide binding] 632772001630 dimer interface [polypeptide binding]; other site 632772001631 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 632772001632 DinB superfamily; Region: DinB_2; pfam12867 632772001633 Alkylmercury lyase; Region: MerB; pfam03243 632772001634 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 632772001635 DNA binding residues [nucleotide binding] 632772001636 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 632772001637 dimer interface [polypeptide binding]; other site 632772001638 mercury binding site [ion binding]; other site 632772001639 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632772001640 dimerization interface [polypeptide binding]; other site 632772001641 putative DNA binding site [nucleotide binding]; other site 632772001642 putative Zn2+ binding site [ion binding]; other site 632772001643 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 632772001644 arsenical-resistance protein; Region: acr3; TIGR00832 632772001645 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 632772001646 Low molecular weight phosphatase family; Region: LMWPc; cl00105 632772001647 active site 632772001648 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 632772001649 Low molecular weight phosphatase family; Region: LMWPc; cd00115 632772001650 active site 632772001651 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 632772001652 Low molecular weight phosphatase family; Region: LMWPc; cl00105 632772001653 active site 632772001654 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 632772001655 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 632772001656 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 632772001657 P loop; other site 632772001658 Nucleotide binding site [chemical binding]; other site 632772001659 DTAP/Switch II; other site 632772001660 Switch I; other site 632772001661 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 632772001662 P loop; other site 632772001663 Nucleotide binding site [chemical binding]; other site 632772001664 DTAP/Switch II; other site 632772001665 Switch I; other site 632772001666 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 632772001667 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 632772001668 helix_turn_helix, mercury resistance; Region: HTH_MERR; smart00422 632772001669 DNA binding residues [nucleotide binding] 632772001670 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 632772001671 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 632772001672 Sulfate transporter family; Region: Sulfate_transp; pfam00916 632772001673 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 632772001674 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 632772001675 Ligand Binding Site [chemical binding]; other site 632772001676 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 632772001677 CrcB-like protein; Region: CRCB; pfam02537 632772001678 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 632772001679 active site 632772001680 metal binding site [ion binding]; metal-binding site 632772001681 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 632772001682 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 632772001683 Presynaptic Site I dimer interface [polypeptide binding]; other site 632772001684 catalytic residues [active] 632772001685 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 632772001686 Synaptic Flat tetramer interface [polypeptide binding]; other site 632772001687 Synaptic Site I dimer interface [polypeptide binding]; other site 632772001688 DNA binding site [nucleotide binding] 632772001689 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 632772001690 DNA-binding interface [nucleotide binding]; DNA binding site 632772001691 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 632772001692 Predicted membrane protein (DUF2243); Region: DUF2243; cl01783 632772001693 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 632772001694 Rhodanese-like domain; Region: Rhodanese; pfam00581 632772001695 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 632772001696 active site residue [active] 632772001697 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 632772001698 Domain of unknown function DUF302; Region: DUF302; pfam03625 632772001699 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 632772001700 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 632772001701 putative homotetramer interface [polypeptide binding]; other site 632772001702 putative homodimer interface [polypeptide binding]; other site 632772001703 putative allosteric switch controlling residues; other site 632772001704 putative metal binding site [ion binding]; other site 632772001705 putative homodimer-homodimer interface [polypeptide binding]; other site 632772001706 MMPL family; Region: MMPL; pfam03176 632772001707 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 632772001708 active site residue [active] 632772001709 potential frameshift: common BLAST hit: gi|224990140|ref|YP_002644827.1| sulfite oxidase 632772001710 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 632772001711 Moco binding site; other site 632772001712 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 632772001713 metal coordination site [ion binding]; other site 632772001714 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 632772001715 active site 632772001716 DNA binding site [nucleotide binding] 632772001717 Transcription factor WhiB; Region: Whib; pfam02467 632772001718 FOG: CBS domain [General function prediction only]; Region: COG0517 632772001719 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 632772001720 Ferritin-like domain; Region: Ferritin; pfam00210 632772001721 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 632772001722 dimerization interface [polypeptide binding]; other site 632772001723 DPS ferroxidase diiron center [ion binding]; other site 632772001724 ion pore; other site 632772001725 Transcription factor WhiB; Region: Whib; pfam02467 632772001726 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 632772001727 MgtC family; Region: MgtC; pfam02308 632772001728 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 632772001729 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 632772001730 phosphopeptide binding site; other site 632772001731 Predicted transcriptional regulator [Transcription]; Region: COG2345 632772001732 Helix-turn-helix domain; Region: HTH_20; pfam12840 632772001733 putative DNA binding site [nucleotide binding]; other site 632772001734 putative Zn2+ binding site [ion binding]; other site 632772001735 YCII-related domain; Region: YCII; cl00999 632772001736 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 632772001737 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 632772001738 active site 632772001739 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 632772001740 aconitate hydratase; Validated; Region: PRK09277 632772001741 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 632772001742 substrate binding site [chemical binding]; other site 632772001743 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 632772001744 ligand binding site [chemical binding]; other site 632772001745 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 632772001746 substrate binding site [chemical binding]; other site 632772001747 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 632772001748 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 632772001749 Protein of unknown function, DUF488; Region: DUF488; cl01246 632772001750 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 632772001751 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 632772001752 Transcriptional regulators [Transcription]; Region: MarR; COG1846 632772001753 MarR family; Region: MarR_2; pfam12802 632772001754 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 632772001755 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 632772001756 active site 632772001757 FMN binding site [chemical binding]; other site 632772001758 substrate binding site [chemical binding]; other site 632772001759 3Fe-4S cluster binding site [ion binding]; other site 632772001760 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 632772001761 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 632772001762 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 632772001763 putative active site [active] 632772001764 transaldolase; Provisional; Region: PRK03903 632772001765 catalytic residue [active] 632772001766 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632772001767 dimerization interface [polypeptide binding]; other site 632772001768 putative DNA binding site [nucleotide binding]; other site 632772001769 Predicted transcriptional regulator [Transcription]; Region: COG2345 632772001770 putative Zn2+ binding site [ion binding]; other site 632772001771 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 632772001772 active site 632772001773 Protein of unknown function, DUF488; Region: DUF488; pfam04343 632772001774 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632772001775 dimerization interface [polypeptide binding]; other site 632772001776 putative DNA binding site [nucleotide binding]; other site 632772001777 Predicted transcriptional regulator [Transcription]; Region: COG2345 632772001778 putative Zn2+ binding site [ion binding]; other site 632772001779 Ferredoxin [Energy production and conversion]; Region: COG1146 632772001780 4Fe-4S binding domain; Region: Fer4; pfam00037 632772001781 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 632772001782 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 632772001783 D-pathway; other site 632772001784 Putative ubiquinol binding site [chemical binding]; other site 632772001785 Low-spin heme (heme b) binding site [chemical binding]; other site 632772001786 Putative water exit pathway; other site 632772001787 Binuclear center (heme o3/CuB) [ion binding]; other site 632772001788 K-pathway; other site 632772001789 Putative proton exit pathway; other site 632772001790 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 632772001791 heme-binding site [chemical binding]; other site 632772001792 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 632772001793 Protein of unknown function (DUF952); Region: DUF952; pfam06108 632772001794 Predicted transcriptional regulator [Transcription]; Region: COG2345 632772001795 HTH domain; Region: HTH_11; cl17392 632772001796 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 632772001797 synthetase active site [active] 632772001798 NTP binding site [chemical binding]; other site 632772001799 metal binding site [ion binding]; metal-binding site 632772001800 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 632772001801 MarR family; Region: MarR; pfam01047 632772001802 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 632772001803 active site clefts [active] 632772001804 zinc binding site [ion binding]; other site 632772001805 dimer interface [polypeptide binding]; other site 632772001806 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632772001807 dimerization interface [polypeptide binding]; other site 632772001808 putative DNA binding site [nucleotide binding]; other site 632772001809 putative Zn2+ binding site [ion binding]; other site 632772001810 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 632772001811 potential protein location (hypothetical protein) that overlaps protein ( monooxygenase) 632772001812 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 632772001813 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 632772001814 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 632772001815 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 632772001816 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 632772001817 SnoaL-like domain; Region: SnoaL_2; pfam12680 632772001818 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 632772001819 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 632772001820 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 632772001821 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 632772001822 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 632772001823 acyl-activating enzyme (AAE) consensus motif; other site 632772001824 putative AMP binding site [chemical binding]; other site 632772001825 putative active site [active] 632772001826 putative CoA binding site [chemical binding]; other site 632772001827 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 632772001828 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 632772001829 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 632772001830 NADP binding site [chemical binding]; other site 632772001831 homodimer interface [polypeptide binding]; other site 632772001832 active site 632772001833 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 632772001834 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 632772001835 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 632772001836 NAD binding site [chemical binding]; other site 632772001837 catalytic Zn binding site [ion binding]; other site 632772001838 substrate binding site [chemical binding]; other site 632772001839 structural Zn binding site [ion binding]; other site 632772001840 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 632772001841 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 632772001842 NAD(P) binding site [chemical binding]; other site 632772001843 catalytic residues [active] 632772001844 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 632772001845 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 632772001846 phosphate binding site [ion binding]; other site 632772001847 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 632772001848 SnoaL-like domain; Region: SnoaL_2; pfam12680 632772001849 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 632772001850 Clp amino terminal domain; Region: Clp_N; pfam02861 632772001851 Clp amino terminal domain; Region: Clp_N; pfam02861 632772001852 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632772001853 Walker A motif; other site 632772001854 ATP binding site [chemical binding]; other site 632772001855 Walker B motif; other site 632772001856 arginine finger; other site 632772001857 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632772001858 Walker A motif; other site 632772001859 ATP binding site [chemical binding]; other site 632772001860 Walker B motif; other site 632772001861 arginine finger; other site 632772001862 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 632772001863 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 632772001864 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 632772001865 hydroxyglutarate oxidase; Provisional; Region: PRK11728 632772001866 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 632772001867 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632772001868 Walker A motif; other site 632772001869 ATP binding site [chemical binding]; other site 632772001870 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 632772001871 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 632772001872 catalytic residues [active] 632772001873 catalytic nucleophile [active] 632772001874 Presynaptic Site I dimer interface [polypeptide binding]; other site 632772001875 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 632772001876 Synaptic Flat tetramer interface [polypeptide binding]; other site 632772001877 Synaptic Site I dimer interface [polypeptide binding]; other site 632772001878 DNA binding site [nucleotide binding] 632772001879 Predicted ATPase [General function prediction only]; Region: COG3903 632772001880 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632772001881 DNA binding residues [nucleotide binding] 632772001882 dimerization interface [polypeptide binding]; other site 632772001883 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 632772001884 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 632772001885 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772001886 SEC-C motif; Region: SEC-C; pfam02810 632772001887 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 632772001888 RNB domain; Region: RNB; pfam00773 632772001889 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 632772001890 Helicase associated domain; Region: HA; pfam03457 632772001891 Helicase associated domain; Region: HA; pfam03457 632772001892 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 632772001893 Protein of unknown function (DUF497); Region: DUF497; cl01108 632772001894 potential frameshift: common BLAST hit: gi|183980454|ref|YP_001848745.1| transmembrane protein 632772001895 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 632772001896 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 632772001897 Domain of unknown function (DUF4041); Region: DUF4041; pfam13250 632772001898 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 632772001899 PIN domain; Region: PIN_3; pfam13470 632772001900 Helix-turn-helix domain; Region: HTH_17; pfam12728 632772001901 Guanylyl transferase CofC like; Region: CofC; cl17472 632772001902 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 632772001903 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 632772001904 biotin synthase; Provisional; Region: PRK08508 632772001905 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 632772001906 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 632772001907 nucleotide binding site [chemical binding]; other site 632772001908 NEF interaction site [polypeptide binding]; other site 632772001909 SBD interface [polypeptide binding]; other site 632772001910 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 632772001911 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 632772001912 dimer interface [polypeptide binding]; other site 632772001913 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 632772001914 chaperone protein DnaJ; Provisional; Region: PRK14279 632772001915 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 632772001916 HSP70 interaction site [polypeptide binding]; other site 632772001917 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 632772001918 Zn binding sites [ion binding]; other site 632772001919 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 632772001920 dimer interface [polypeptide binding]; other site 632772001921 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 632772001922 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 632772001923 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 632772001924 DNA binding residues [nucleotide binding] 632772001925 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 632772001926 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 632772001927 putative dimer interface [polypeptide binding]; other site 632772001928 DnaJ domain; Region: DnaJ; pfam00226 632772001929 HSP70 interaction site [polypeptide binding]; other site 632772001930 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 632772001931 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 632772001932 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 632772001933 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772001934 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772001935 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 632772001936 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 632772001937 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 632772001938 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632772001939 Walker A motif; other site 632772001940 ATP binding site [chemical binding]; other site 632772001941 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 632772001942 potential frameshift: common BLAST hit: gi|119716981|ref|YP_923946.1| integrase catalytic subunit 632772001943 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 632772001944 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 632772001945 hypothetical protein; Provisional; Region: PRK06834 632772001946 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632772001947 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632772001948 active site 632772001949 phosphorylation site [posttranslational modification] 632772001950 intermolecular recognition site; other site 632772001951 dimerization interface [polypeptide binding]; other site 632772001952 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632772001953 DNA binding residues [nucleotide binding] 632772001954 dimerization interface [polypeptide binding]; other site 632772001955 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 632772001956 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 632772001957 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 632772001958 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 632772001959 Histidine kinase; Region: HisKA_3; pfam07730 632772001960 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632772001961 ATP binding site [chemical binding]; other site 632772001962 Mg2+ binding site [ion binding]; other site 632772001963 G-X-G motif; other site 632772001964 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 632772001965 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632772001966 active site 632772001967 phosphorylation site [posttranslational modification] 632772001968 intermolecular recognition site; other site 632772001969 dimerization interface [polypeptide binding]; other site 632772001970 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 632772001971 DNA binding site [nucleotide binding] 632772001972 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 632772001973 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 632772001974 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 632772001975 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772001976 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 632772001977 DNA binding residues [nucleotide binding] 632772001978 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 632772001979 catalytic residues [active] 632772001980 catalytic nucleophile [active] 632772001981 potential frameshift: common BLAST hit: gi|111017629|ref|YP_700601.1| transposase 632772001982 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 632772001983 Uncharacterized conserved protein [Function unknown]; Region: COG2128 632772001984 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 632772001985 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 632772001986 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 632772001987 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772001988 substrate binding site [chemical binding]; other site 632772001989 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 632772001990 oxyanion hole (OAH) forming residues; other site 632772001991 trimer interface [polypeptide binding]; other site 632772001992 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 632772001993 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 632772001994 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 632772001995 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 632772001996 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 632772001997 anti sigma factor interaction site; other site 632772001998 regulatory phosphorylation site [posttranslational modification]; other site 632772001999 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 632772002000 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 632772002001 active site 632772002002 homotetramer interface [polypeptide binding]; other site 632772002003 GAF domain; Region: GAF; pfam01590 632772002004 ANTAR domain; Region: ANTAR; pfam03861 632772002005 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 632772002006 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632772002007 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 632772002008 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 632772002009 DNA binding residues [nucleotide binding] 632772002010 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 632772002011 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 632772002012 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 632772002013 DNA-binding site [nucleotide binding]; DNA binding site 632772002014 RNA-binding motif; other site 632772002015 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 632772002016 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 632772002017 dimerization interface [polypeptide binding]; other site 632772002018 DPS ferroxidase diiron center [ion binding]; other site 632772002019 ion pore; other site 632772002020 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 632772002021 Protein of unknown function (DUF664); Region: DUF664; pfam04978 632772002022 DinB superfamily; Region: DinB_2; pfam12867 632772002023 Cutinase; Region: Cutinase; pfam01083 632772002024 GAF domain; Region: GAF; cl17456 632772002025 GAF domain; Region: GAF_2; pfam13185 632772002026 ANTAR domain; Region: ANTAR; pfam03861 632772002027 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 632772002028 anti sigma factor interaction site; other site 632772002029 regulatory phosphorylation site [posttranslational modification]; other site 632772002030 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 632772002031 minor groove reading motif; other site 632772002032 helix-hairpin-helix signature motif; other site 632772002033 active site 632772002034 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 632772002035 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 632772002036 oligomer interface [polypeptide binding]; other site 632772002037 metal binding site [ion binding]; metal-binding site 632772002038 metal binding site [ion binding]; metal-binding site 632772002039 putative Cl binding site [ion binding]; other site 632772002040 aspartate ring; other site 632772002041 basic sphincter; other site 632772002042 hydrophobic gate; other site 632772002043 periplasmic entrance; other site 632772002044 YacP-like NYN domain; Region: NYN_YacP; cl01491 632772002045 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 632772002046 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 632772002047 hydrophobic ligand binding site; other site 632772002048 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 632772002049 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632772002050 motif II; other site 632772002051 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 632772002052 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 632772002053 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 632772002054 PhoU domain; Region: PhoU; pfam01895 632772002055 PhoU domain; Region: PhoU; pfam01895 632772002056 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 632772002057 beta-alpha-beta structure motif; other site 632772002058 NAD binding pocket [chemical binding]; other site 632772002059 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 632772002060 catalytic core [active] 632772002061 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 632772002062 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 632772002063 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 632772002064 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 632772002065 Beta-lactamase; Region: Beta-lactamase; pfam00144 632772002066 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 632772002067 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 632772002068 dimer interface [polypeptide binding]; other site 632772002069 active site 632772002070 catalytic residue [active] 632772002071 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772002072 S-adenosylmethionine binding site [chemical binding]; other site 632772002073 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 632772002074 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772002075 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 632772002076 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 632772002077 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 632772002078 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 632772002079 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 632772002080 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 632772002081 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 632772002082 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 632772002083 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 632772002084 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 632772002085 DUF35 OB-fold domain; Region: DUF35; pfam01796 632772002086 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 632772002087 Predicted ATPase [General function prediction only]; Region: COG3903 632772002088 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632772002089 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632772002090 DNA binding residues [nucleotide binding] 632772002091 dimerization interface [polypeptide binding]; other site 632772002092 oxidoreductase; Provisional; Region: PRK12743 632772002093 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772002094 NAD(P) binding site [chemical binding]; other site 632772002095 active site 632772002096 Secretory lipase; Region: LIP; pfam03583 632772002097 Condensation domain; Region: Condensation; pfam00668 632772002098 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 632772002099 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772002100 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772002101 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 632772002102 acyl-activating enzyme (AAE) consensus motif; other site 632772002103 AMP binding site [chemical binding]; other site 632772002104 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772002105 Condensation domain; Region: Condensation; pfam00668 632772002106 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 632772002107 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772002108 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772002109 acyl-activating enzyme (AAE) consensus motif; other site 632772002110 AMP binding site [chemical binding]; other site 632772002111 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772002112 peptide synthase; Provisional; Region: PRK12316 632772002113 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772002114 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772002115 acyl-activating enzyme (AAE) consensus motif; other site 632772002116 AMP binding site [chemical binding]; other site 632772002117 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772002118 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 632772002119 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772002120 acyl-activating enzyme (AAE) consensus motif; other site 632772002121 AMP binding site [chemical binding]; other site 632772002122 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772002123 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772002124 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772002125 acyl-activating enzyme (AAE) consensus motif; other site 632772002126 AMP binding site [chemical binding]; other site 632772002127 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772002128 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 632772002129 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772002130 acyl-activating enzyme (AAE) consensus motif; other site 632772002131 AMP binding site [chemical binding]; other site 632772002132 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772002133 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 632772002134 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772002135 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772002136 acyl-activating enzyme (AAE) consensus motif; other site 632772002137 AMP binding site [chemical binding]; other site 632772002138 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772002139 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 632772002140 Condensation domain; Region: Condensation; pfam00668 632772002141 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772002142 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 632772002143 acyl-activating enzyme (AAE) consensus motif; other site 632772002144 AMP binding site [chemical binding]; other site 632772002145 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772002146 Condensation domain; Region: Condensation; pfam00668 632772002147 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 632772002148 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772002149 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772002150 acyl-activating enzyme (AAE) consensus motif; other site 632772002151 AMP binding site [chemical binding]; other site 632772002152 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772002153 Condensation domain; Region: Condensation; pfam00668 632772002154 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 632772002155 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772002156 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772002157 acyl-activating enzyme (AAE) consensus motif; other site 632772002158 AMP binding site [chemical binding]; other site 632772002159 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772002160 Condensation domain; Region: Condensation; pfam00668 632772002161 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 632772002162 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772002163 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772002164 acyl-activating enzyme (AAE) consensus motif; other site 632772002165 AMP binding site [chemical binding]; other site 632772002166 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772002167 Condensation domain; Region: Condensation; pfam00668 632772002168 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 632772002169 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772002170 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772002171 acyl-activating enzyme (AAE) consensus motif; other site 632772002172 AMP binding site [chemical binding]; other site 632772002173 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772002174 Condensation domain; Region: Condensation; pfam00668 632772002175 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 632772002176 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772002177 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772002178 acyl-activating enzyme (AAE) consensus motif; other site 632772002179 AMP binding site [chemical binding]; other site 632772002180 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772002181 Condensation domain; Region: Condensation; pfam00668 632772002182 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 632772002183 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772002184 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772002185 acyl-activating enzyme (AAE) consensus motif; other site 632772002186 AMP binding site [chemical binding]; other site 632772002187 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772002188 Condensation domain; Region: Condensation; pfam00668 632772002189 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 632772002190 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772002191 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772002192 acyl-activating enzyme (AAE) consensus motif; other site 632772002193 AMP binding site [chemical binding]; other site 632772002194 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772002195 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 632772002196 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772002197 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772002198 acyl-activating enzyme (AAE) consensus motif; other site 632772002199 AMP binding site [chemical binding]; other site 632772002200 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772002201 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 632772002202 Ligand binding site; other site 632772002203 Putative Catalytic site; other site 632772002204 DXD motif; other site 632772002205 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 632772002206 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 632772002207 putative active site [active] 632772002208 catalytic triad [active] 632772002209 putative dimer interface [polypeptide binding]; other site 632772002210 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 632772002211 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 632772002212 active site 632772002213 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 632772002214 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632772002215 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632772002216 active site 632772002217 phosphorylation site [posttranslational modification] 632772002218 intermolecular recognition site; other site 632772002219 dimerization interface [polypeptide binding]; other site 632772002220 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632772002221 DNA binding residues [nucleotide binding] 632772002222 dimerization interface [polypeptide binding]; other site 632772002223 FOG: CBS domain [General function prediction only]; Region: COG0517 632772002224 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 632772002225 YCII-related domain; Region: YCII; cl00999 632772002226 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 632772002227 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 632772002228 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 632772002229 Cupin domain; Region: Cupin_2; pfam07883 632772002230 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 632772002231 putative dimer interface [polypeptide binding]; other site 632772002232 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 632772002233 active site 632772002234 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 632772002235 Histidine kinase; Region: HisKA_3; pfam07730 632772002236 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 632772002237 hypothetical protein; Provisional; Region: PRK10621 632772002238 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 632772002239 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 632772002240 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 632772002241 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 632772002242 Predicted membrane protein [Function unknown]; Region: COG2311 632772002243 Protein of unknown function (DUF418); Region: DUF418; cl12135 632772002244 Protein of unknown function (DUF418); Region: DUF418; pfam04235 632772002245 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772002246 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772002247 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 632772002248 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 632772002249 RibD C-terminal domain; Region: RibD_C; cl17279 632772002250 potential frameshift: common BLAST hit: gi|182440507|ref|YP_001828226.1| ABC-type Fe3+-siderophore transporter substrate-binding 632772002251 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 632772002252 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 632772002253 intersubunit interface [polypeptide binding]; other site 632772002254 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 632772002255 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 632772002256 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 632772002257 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 632772002258 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 632772002259 precorrin-3B synthase; Region: CobG; TIGR02435 632772002260 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 632772002261 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 632772002262 Precorrin-8X methylmutase; Region: CbiC; pfam02570 632772002263 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 632772002264 active site 632772002265 SAM binding site [chemical binding]; other site 632772002266 homodimer interface [polypeptide binding]; other site 632772002267 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 632772002268 active site 632772002269 SAM binding site [chemical binding]; other site 632772002270 homodimer interface [polypeptide binding]; other site 632772002271 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 632772002272 Transcriptional regulator [Transcription]; Region: LysR; COG0583 632772002273 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 632772002274 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 632772002275 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 632772002276 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 632772002277 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 632772002278 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 632772002279 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 632772002280 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 632772002281 Probable transposase; Region: OrfB_IS605; pfam01385 632772002282 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 632772002283 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 632772002284 DNA binding residues [nucleotide binding] 632772002285 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772002286 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632772002287 potential frameshift: common BLAST hit: gi|111017206|ref|YP_700178.1| multidrug ABC transporter 632772002288 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 632772002289 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 632772002290 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 632772002291 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 632772002292 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 632772002293 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 632772002294 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772002295 dimer interface [polypeptide binding]; other site 632772002296 conserved gate region; other site 632772002297 putative PBP binding loops; other site 632772002298 ABC-ATPase subunit interface; other site 632772002299 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 632772002300 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632772002301 Walker A/P-loop; other site 632772002302 ATP binding site [chemical binding]; other site 632772002303 Q-loop/lid; other site 632772002304 ABC transporter signature motif; other site 632772002305 Walker B; other site 632772002306 D-loop; other site 632772002307 H-loop/switch region; other site 632772002308 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 632772002309 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772002310 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 632772002311 Chorismate mutase type II; Region: CM_2; cl00693 632772002312 Predicted membrane protein [Function unknown]; Region: COG2259 632772002313 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 632772002314 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 632772002315 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 632772002316 ABC-2 type transporter; Region: ABC2_membrane; cl17235 632772002317 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632772002318 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 632772002319 Walker A/P-loop; other site 632772002320 ATP binding site [chemical binding]; other site 632772002321 Q-loop/lid; other site 632772002322 ABC transporter signature motif; other site 632772002323 Walker B; other site 632772002324 D-loop; other site 632772002325 H-loop/switch region; other site 632772002326 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 632772002327 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 632772002328 RNA polymerase factor sigma-70; Validated; Region: PRK08241 632772002329 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632772002330 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 632772002331 DNA binding residues [nucleotide binding] 632772002332 SnoaL-like domain; Region: SnoaL_2; pfam12680 632772002333 Beta-lactamase; Region: Beta-lactamase; pfam00144 632772002334 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 632772002335 Cupin; Region: Cupin_1; smart00835 632772002336 Cupin; Region: Cupin_1; smart00835 632772002337 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 632772002338 putative hydrophobic ligand binding site [chemical binding]; other site 632772002339 Gas vesicle protein; Region: Gas_vesicle; cl02954 632772002340 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 632772002341 Gas vesicle protein G; Region: GvpG; pfam05120 632772002342 Gas vesicle synthesis protein GvpO; Region: GvpO; pfam05800 632772002343 Gas vesicle protein; Region: Gas_vesicle; pfam00741 632772002344 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 632772002345 Gas vesicle protein; Region: Gas_vesicle; cl02954 632772002346 Gas vesicle protein K; Region: GvpK; pfam05121 632772002347 CsbD-like; Region: CsbD; pfam05532 632772002348 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 632772002349 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 632772002350 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 632772002351 classical (c) SDRs; Region: SDR_c; cd05233 632772002352 NAD(P) binding site [chemical binding]; other site 632772002353 active site 632772002354 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 632772002355 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 632772002356 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 632772002357 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 632772002358 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 632772002359 DNA binding residues [nucleotide binding] 632772002360 Second Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt2; cd04773 632772002361 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 632772002362 DNA binding residues [nucleotide binding] 632772002363 putative dimer interface [polypeptide binding]; other site 632772002364 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772002365 S-adenosylmethionine binding site [chemical binding]; other site 632772002366 SnoaL-like domain; Region: SnoaL_4; pfam13577 632772002367 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 632772002368 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 632772002369 putative ligand binding site [chemical binding]; other site 632772002370 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 632772002371 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 632772002372 substrate binding pocket [chemical binding]; other site 632772002373 membrane-bound complex binding site; other site 632772002374 hinge residues; other site 632772002375 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 632772002376 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632772002377 motif II; other site 632772002378 DoxX-like family; Region: DoxX_2; pfam13564 632772002379 CHASE3 domain; Region: CHASE3; pfam05227 632772002380 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 632772002381 HAMP domain; Region: HAMP; pfam00672 632772002382 dimerization interface [polypeptide binding]; other site 632772002383 Histidine kinase; Region: HisKA_3; pfam07730 632772002384 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632772002385 ATP binding site [chemical binding]; other site 632772002386 Mg2+ binding site [ion binding]; other site 632772002387 G-X-G motif; other site 632772002388 Protein of unknown function (DUF419); Region: DUF419; pfam04237 632772002389 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 632772002390 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 632772002391 phosphopeptide binding site; other site 632772002392 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632772002393 DNA binding residues [nucleotide binding] 632772002394 dimerization interface [polypeptide binding]; other site 632772002395 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632772002396 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 632772002397 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 632772002398 putative metal binding site [ion binding]; other site 632772002399 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632772002400 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632772002401 DNA binding residues [nucleotide binding] 632772002402 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 632772002403 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 632772002404 Uncharacterized conserved protein [Function unknown]; Region: COG3391 632772002405 Uncharacterized conserved protein [Function unknown]; Region: COG3391 632772002406 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 632772002407 structural tetrad; other site 632772002408 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 632772002409 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 632772002410 substrate binding pocket [chemical binding]; other site 632772002411 membrane-bound complex binding site; other site 632772002412 hinge residues; other site 632772002413 oxidoreductase; Provisional; Region: PRK06128 632772002414 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 632772002415 NAD binding site [chemical binding]; other site 632772002416 metal binding site [ion binding]; metal-binding site 632772002417 active site 632772002418 Clp amino terminal domain; Region: Clp_N; pfam02861 632772002419 Transcriptional regulator PadR-like family; Region: PadR; cl17335 632772002420 Predicted transcriptional regulators [Transcription]; Region: COG1695 632772002421 rod shape-determining protein MreB; Provisional; Region: PRK13930 632772002422 MreB and similar proteins; Region: MreB_like; cd10225 632772002423 nucleotide binding site [chemical binding]; other site 632772002424 Mg binding site [ion binding]; other site 632772002425 putative protofilament interaction site [polypeptide binding]; other site 632772002426 RodZ interaction site [polypeptide binding]; other site 632772002427 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 632772002428 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 632772002429 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 632772002430 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 632772002431 Domain of unknown function (DUF1931); Region: DUF1931; pfam09123 632772002432 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 632772002433 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 632772002434 FAD binding domain; Region: FAD_binding_4; pfam01565 632772002435 Berberine and berberine like; Region: BBE; pfam08031 632772002436 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 632772002437 active site 632772002438 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 632772002439 active site 632772002440 Protein of unknown function (DUF1688); Region: DUF1688; pfam07958 632772002441 hypothetical protein; Validated; Region: PRK07198 632772002442 GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471 632772002443 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 632772002444 dimerization interface [polypeptide binding]; other site 632772002445 active site 632772002446 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 632772002447 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 632772002448 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 632772002449 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772002450 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 632772002451 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 632772002452 Predicted transcriptional regulators [Transcription]; Region: COG1695 632772002453 Transcriptional regulator PadR-like family; Region: PadR; cl17335 632772002454 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 632772002455 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 632772002456 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 632772002457 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 632772002458 active site 632772002459 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 632772002460 Protein of unknown function (DUF867); Region: DUF867; cl01713 632772002461 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 632772002462 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 632772002463 active site 632772002464 ATP binding site [chemical binding]; other site 632772002465 substrate binding site [chemical binding]; other site 632772002466 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 632772002467 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 632772002468 Catalytic domain of Protein Kinases; Region: PKc; cd00180 632772002469 active site 632772002470 ATP binding site [chemical binding]; other site 632772002471 substrate binding site [chemical binding]; other site 632772002472 activation loop (A-loop); other site 632772002473 Kelch motif; Region: Kelch_1; pfam01344 632772002474 Kelch domain; Region: Kelch; smart00612 632772002475 Kelch motif; Region: Kelch_1; pfam01344 632772002476 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 632772002477 Kelch motif; Region: Kelch_1; pfam01344 632772002478 Kelch domain; Region: Kelch; smart00612 632772002479 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 632772002480 Kelch motif; Region: Kelch_1; pfam01344 632772002481 PAS domain; Region: PAS_9; pfam13426 632772002482 GAF domain; Region: GAF; pfam01590 632772002483 GAF domain; Region: GAF_2; pfam13185 632772002484 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 632772002485 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 632772002486 metal binding site [ion binding]; metal-binding site 632772002487 active site 632772002488 I-site; other site 632772002489 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 632772002490 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632772002491 ATP binding site [chemical binding]; other site 632772002492 Mg2+ binding site [ion binding]; other site 632772002493 G-X-G motif; other site 632772002494 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 632772002495 putative catalytic site [active] 632772002496 putative metal binding site [ion binding]; other site 632772002497 putative phosphate binding site [ion binding]; other site 632772002498 Uncharacterized conserved protein [Function unknown]; Region: COG5276 632772002499 Domain of unknown function (DUF305); Region: DUF305; pfam03713 632772002500 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 632772002501 active site 632772002502 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 632772002503 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 632772002504 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 632772002505 active site 632772002506 metal binding site [ion binding]; metal-binding site 632772002507 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 632772002508 Cupin domain; Region: Cupin_2; cl17218 632772002509 MspA; Region: MspA; pfam09203 632772002510 Uncharacterized conserved protein [Function unknown]; Region: COG2128 632772002511 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 632772002512 TAP-like protein; Region: Abhydrolase_4; pfam08386 632772002513 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 632772002514 Domain of unknown function (DUF364); Region: DUF364; pfam04016 632772002515 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 632772002516 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 632772002517 dimer interface [polypeptide binding]; other site 632772002518 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632772002519 catalytic residue [active] 632772002520 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 632772002521 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 632772002522 active site 632772002523 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772002524 putative substrate translocation pore; other site 632772002525 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772002526 S-adenosylmethionine binding site [chemical binding]; other site 632772002527 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 632772002528 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 632772002529 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 632772002530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772002531 putative PBP binding loops; other site 632772002532 dimer interface [polypeptide binding]; other site 632772002533 ABC-ATPase subunit interface; other site 632772002534 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 632772002535 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 632772002536 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 632772002537 Walker A/P-loop; other site 632772002538 ATP binding site [chemical binding]; other site 632772002539 Q-loop/lid; other site 632772002540 ABC transporter signature motif; other site 632772002541 Walker B; other site 632772002542 D-loop; other site 632772002543 H-loop/switch region; other site 632772002544 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 632772002545 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 632772002546 Walker A/P-loop; other site 632772002547 ATP binding site [chemical binding]; other site 632772002548 Q-loop/lid; other site 632772002549 ABC transporter signature motif; other site 632772002550 Walker B; other site 632772002551 D-loop; other site 632772002552 H-loop/switch region; other site 632772002553 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 632772002554 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 632772002555 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 632772002556 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632772002557 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772002558 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772002559 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772002560 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 632772002561 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 632772002562 putative hydrophobic ligand binding site [chemical binding]; other site 632772002563 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632772002564 dimerization interface [polypeptide binding]; other site 632772002565 putative DNA binding site [nucleotide binding]; other site 632772002566 putative Zn2+ binding site [ion binding]; other site 632772002567 Lsr2; Region: Lsr2; pfam11774 632772002568 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772002569 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632772002570 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 632772002571 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 632772002572 active site 632772002573 Epoxide hydrolase N terminus; Region: EHN; pfam06441 632772002574 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 632772002575 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 632772002576 CGNR zinc finger; Region: zf-CGNR; pfam11706 632772002577 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 632772002578 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772002579 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772002580 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 632772002581 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 632772002582 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 632772002583 Predicted membrane protein [Function unknown]; Region: COG2323 632772002584 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 632772002585 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 632772002586 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 632772002587 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 632772002588 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772002589 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772002590 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 632772002591 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 632772002592 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772002593 acyl-activating enzyme (AAE) consensus motif; other site 632772002594 AMP binding site [chemical binding]; other site 632772002595 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772002596 Transcription factor WhiB; Region: Whib; pfam02467 632772002597 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 632772002598 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 632772002599 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 632772002600 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772002601 short chain dehydrogenase; Provisional; Region: PRK07041 632772002602 NAD(P) binding site [chemical binding]; other site 632772002603 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 632772002604 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632772002605 Walker A/P-loop; other site 632772002606 ATP binding site [chemical binding]; other site 632772002607 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 632772002608 Q-loop/lid; other site 632772002609 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632772002610 ABC transporter signature motif; other site 632772002611 Walker B; other site 632772002612 D-loop; other site 632772002613 H-loop/switch region; other site 632772002614 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632772002615 Walker A/P-loop; other site 632772002616 ATP binding site [chemical binding]; other site 632772002617 Q-loop/lid; other site 632772002618 ABC transporter signature motif; other site 632772002619 Walker B; other site 632772002620 D-loop; other site 632772002621 H-loop/switch region; other site 632772002622 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 632772002623 hydroxyglutarate oxidase; Provisional; Region: PRK11728 632772002624 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 632772002625 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 632772002626 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 632772002627 NAD(P) binding site [chemical binding]; other site 632772002628 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 632772002629 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 632772002630 NAD(P) binding site [chemical binding]; other site 632772002631 catalytic residues [active] 632772002632 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 632772002633 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 632772002634 Transcriptional regulator [Transcription]; Region: LysR; COG0583 632772002635 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 632772002636 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 632772002637 dimerization interface [polypeptide binding]; other site 632772002638 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 632772002639 FAD binding domain; Region: FAD_binding_4; pfam01565 632772002640 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 632772002641 Cysteine-rich domain; Region: CCG; pfam02754 632772002642 Transcriptional regulators [Transcription]; Region: GntR; COG1802 632772002643 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772002644 DNA-binding site [nucleotide binding]; DNA binding site 632772002645 FCD domain; Region: FCD; pfam07729 632772002646 ChaB; Region: ChaB; cl01887 632772002647 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 632772002648 3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074 632772002649 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772002650 S-adenosylmethionine binding site [chemical binding]; other site 632772002651 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 632772002652 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 632772002653 active site 632772002654 metal binding site [ion binding]; metal-binding site 632772002655 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772002656 Methyltransferase domain; Region: Methyltransf_31; pfam13847 632772002657 S-adenosylmethionine binding site [chemical binding]; other site 632772002658 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 632772002659 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 632772002660 dimer interface [polypeptide binding]; other site 632772002661 NADP binding site [chemical binding]; other site 632772002662 catalytic residues [active] 632772002663 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 632772002664 tetramer (dimer of dimers) interface [polypeptide binding]; other site 632772002665 active site 632772002666 dimer interface [polypeptide binding]; other site 632772002667 phosphoglycolate phosphatase; Provisional; Region: PRK13222 632772002668 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 632772002669 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 632772002670 N- and C-terminal domain interface [polypeptide binding]; other site 632772002671 D-xylulose kinase; Region: XylB; TIGR01312 632772002672 active site 632772002673 MgATP binding site [chemical binding]; other site 632772002674 catalytic site [active] 632772002675 metal binding site [ion binding]; metal-binding site 632772002676 xylulose binding site [chemical binding]; other site 632772002677 homodimer interface [polypeptide binding]; other site 632772002678 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 632772002679 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 632772002680 NAD(P) binding site [chemical binding]; other site 632772002681 catalytic residues [active] 632772002682 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299 632772002683 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 632772002684 ligand binding site [chemical binding]; other site 632772002685 NAD binding site [chemical binding]; other site 632772002686 catalytic site [active] 632772002687 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 632772002688 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 632772002689 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 632772002690 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772002691 NAD(P) binding site [chemical binding]; other site 632772002692 active site 632772002693 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 632772002694 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 632772002695 TM-ABC transporter signature motif; other site 632772002696 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 632772002697 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 632772002698 Walker A/P-loop; other site 632772002699 ATP binding site [chemical binding]; other site 632772002700 Q-loop/lid; other site 632772002701 ABC transporter signature motif; other site 632772002702 Walker B; other site 632772002703 D-loop; other site 632772002704 H-loop/switch region; other site 632772002705 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 632772002706 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 632772002707 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 632772002708 ligand binding site [chemical binding]; other site 632772002709 Transcriptional regulators [Transcription]; Region: FadR; COG2186 632772002710 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772002711 DNA-binding site [nucleotide binding]; DNA binding site 632772002712 FCD domain; Region: FCD; pfam07729 632772002713 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 632772002714 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 632772002715 NAD(P) binding site [chemical binding]; other site 632772002716 catalytic residues [active] 632772002717 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 632772002718 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 632772002719 PYR/PP interface [polypeptide binding]; other site 632772002720 dimer interface [polypeptide binding]; other site 632772002721 TPP binding site [chemical binding]; other site 632772002722 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 632772002723 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 632772002724 TPP-binding site [chemical binding]; other site 632772002725 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 632772002726 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 632772002727 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 632772002728 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 632772002729 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 632772002730 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 632772002731 ligand binding site [chemical binding]; other site 632772002732 NAD binding site [chemical binding]; other site 632772002733 dimerization interface [polypeptide binding]; other site 632772002734 catalytic site [active] 632772002735 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 632772002736 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 632772002737 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 632772002738 pyruvate carboxylase; Reviewed; Region: PRK12999 632772002739 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 632772002740 ATP-grasp domain; Region: ATP-grasp_4; cl17255 632772002741 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 632772002742 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 632772002743 active site 632772002744 catalytic residues [active] 632772002745 metal binding site [ion binding]; metal-binding site 632772002746 homodimer binding site [polypeptide binding]; other site 632772002747 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 632772002748 carboxyltransferase (CT) interaction site; other site 632772002749 biotinylation site [posttranslational modification]; other site 632772002750 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 632772002751 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 632772002752 Metal-binding active site; metal-binding site 632772002753 short chain dehydrogenase; Provisional; Region: PRK06198 632772002754 classical (c) SDRs; Region: SDR_c; cd05233 632772002755 NAD(P) binding site [chemical binding]; other site 632772002756 active site 632772002757 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 632772002758 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 632772002759 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 632772002760 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 632772002761 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 632772002762 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 632772002763 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 632772002764 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 632772002765 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 632772002766 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 632772002767 putative ligand binding site [chemical binding]; other site 632772002768 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 632772002769 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 632772002770 TM-ABC transporter signature motif; other site 632772002771 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 632772002772 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 632772002773 Walker A/P-loop; other site 632772002774 ATP binding site [chemical binding]; other site 632772002775 Q-loop/lid; other site 632772002776 ABC transporter signature motif; other site 632772002777 Walker B; other site 632772002778 D-loop; other site 632772002779 H-loop/switch region; other site 632772002780 Transcriptional regulators [Transcription]; Region: PurR; COG1609 632772002781 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 632772002782 DNA binding site [nucleotide binding] 632772002783 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 632772002784 putative ligand binding site [chemical binding]; other site 632772002785 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 632772002786 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 632772002787 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 632772002788 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 632772002789 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 632772002790 tetrameric interface [polypeptide binding]; other site 632772002791 NAD binding site [chemical binding]; other site 632772002792 catalytic residues [active] 632772002793 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 632772002794 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772002795 putative substrate translocation pore; other site 632772002796 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772002797 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 632772002798 Ligand Binding Site [chemical binding]; other site 632772002799 potential frameshift: common BLAST hit: gi|111023399|ref|YP_706371.1| transposase 632772002800 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 632772002801 RibD C-terminal domain; Region: RibD_C; cl17279 632772002802 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 632772002803 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 632772002804 putative dimer interface [polypeptide binding]; other site 632772002805 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 632772002806 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772002807 S-adenosylmethionine binding site [chemical binding]; other site 632772002808 potential frameshift: common BLAST hit: gi|111019883|ref|YP_702855.1| aldehyde dehydrogenase 632772002809 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 632772002810 NAD(P) binding site [chemical binding]; other site 632772002811 catalytic residues [active] 632772002812 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 632772002813 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 632772002814 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 632772002815 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 632772002816 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 632772002817 inhibitor site; inhibition site 632772002818 active site 632772002819 dimer interface [polypeptide binding]; other site 632772002820 catalytic residue [active] 632772002821 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 632772002822 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 632772002823 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 632772002824 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 632772002825 catalytic site [active] 632772002826 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 632772002827 dimer interface [polypeptide binding]; other site 632772002828 FMN binding site [chemical binding]; other site 632772002829 NADPH bind site [chemical binding]; other site 632772002830 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 632772002831 classical (c) SDRs; Region: SDR_c; cd05233 632772002832 NAD(P) binding site [chemical binding]; other site 632772002833 active site 632772002834 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 632772002835 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 632772002836 putative active site [active] 632772002837 putative NTP binding site [chemical binding]; other site 632772002838 putative nucleic acid binding site [nucleotide binding]; other site 632772002839 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950 632772002840 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 632772002841 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 632772002842 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 632772002843 CoA-transferase family III; Region: CoA_transf_3; pfam02515 632772002844 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772002845 putative substrate translocation pore; other site 632772002846 D-galactonate transporter; Region: 2A0114; TIGR00893 632772002847 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 632772002848 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 632772002849 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772002850 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632772002851 putative substrate translocation pore; other site 632772002852 Transcriptional regulator [Transcription]; Region: LysR; COG0583 632772002853 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 632772002854 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 632772002855 dimerization interface [polypeptide binding]; other site 632772002856 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 632772002857 Nitronate monooxygenase; Region: NMO; pfam03060 632772002858 FMN binding site [chemical binding]; other site 632772002859 substrate binding site [chemical binding]; other site 632772002860 putative catalytic residue [active] 632772002861 Transcriptional regulator [Transcription]; Region: LysR; COG0583 632772002862 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 632772002863 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 632772002864 dimerization interface [polypeptide binding]; other site 632772002865 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 632772002866 basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cd12193 632772002867 DNA binding site [nucleotide binding] 632772002868 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772002869 metabolite-proton symporter; Region: 2A0106; TIGR00883 632772002870 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772002871 putative substrate translocation pore; other site 632772002872 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 632772002873 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 632772002874 FMN binding site [chemical binding]; other site 632772002875 substrate binding site [chemical binding]; other site 632772002876 putative catalytic residue [active] 632772002877 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 632772002878 Cupin domain; Region: Cupin_2; pfam07883 632772002879 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 632772002880 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 632772002881 active site 632772002882 SAM binding site [chemical binding]; other site 632772002883 homodimer interface [polypeptide binding]; other site 632772002884 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 632772002885 active site 632772002886 putative homodimer interface [polypeptide binding]; other site 632772002887 SAM binding site [chemical binding]; other site 632772002888 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 632772002889 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772002890 S-adenosylmethionine binding site [chemical binding]; other site 632772002891 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772002892 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 632772002893 NAD(P) binding site [chemical binding]; other site 632772002894 active site 632772002895 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 632772002896 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 632772002897 Ligand binding site; other site 632772002898 Putative Catalytic site; other site 632772002899 DXD motif; other site 632772002900 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 632772002901 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 632772002902 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 632772002903 active site 632772002904 5'-3' exonuclease (including N-terminal domain of PolI) [DNA replication, recombination, and repair]; Region: Exo; COG0258 632772002905 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 632772002906 active site 632772002907 metal binding site 1 [ion binding]; metal-binding site 632772002908 putative 5' ssDNA interaction site; other site 632772002909 metal binding site 3; metal-binding site 632772002910 metal binding site 2 [ion binding]; metal-binding site 632772002911 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 632772002912 putative DNA binding site [nucleotide binding]; other site 632772002913 putative metal binding site [ion binding]; other site 632772002914 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 632772002915 DEAD-like helicases superfamily; Region: DEXDc; smart00487 632772002916 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 632772002917 ATP binding site [chemical binding]; other site 632772002918 putative Mg++ binding site [ion binding]; other site 632772002919 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 632772002920 nucleotide binding region [chemical binding]; other site 632772002921 ATP-binding site [chemical binding]; other site 632772002922 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 632772002923 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 632772002924 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 632772002925 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 632772002926 2-dehydropantoate 2-reductase; Provisional; Region: PRK08229 632772002927 2-dehydropantoate 2-reductase; Provisional; Region: PRK08229 632772002928 Predicted transcriptional regulator [Transcription]; Region: COG2378 632772002929 WYL domain; Region: WYL; pfam13280 632772002930 Predicted transcriptional regulator [Transcription]; Region: COG2378 632772002931 WYL domain; Region: WYL; pfam13280 632772002932 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 632772002933 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 632772002934 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 632772002935 Diacylglycerol kinase catalytic domain (presumed); Region: DAGKc; smart00046 632772002936 diacylglycerol kinase; Reviewed; Region: PRK11914 632772002937 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 632772002938 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 632772002939 active site 632772002940 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 632772002941 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 632772002942 active site 632772002943 Pup-like protein; Region: Pup; cl05289 632772002944 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 632772002945 Domain of unknown function (DUF385); Region: DUF385; cl04387 632772002946 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 632772002947 nudix motif; other site 632772002948 proteasome ATPase; Region: pup_AAA; TIGR03689 632772002949 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632772002950 Walker A motif; other site 632772002951 ATP binding site [chemical binding]; other site 632772002952 Walker B motif; other site 632772002953 arginine finger; other site 632772002954 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 632772002955 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772002956 S-adenosylmethionine binding site [chemical binding]; other site 632772002957 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 632772002958 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 632772002959 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 632772002960 active site 2 [active] 632772002961 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 632772002962 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 632772002963 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 632772002964 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 632772002965 homodimer interface [polypeptide binding]; other site 632772002966 putative metal binding site [ion binding]; other site 632772002967 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 632772002968 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 632772002969 active site 632772002970 hypothetical protein; Validated; Region: PRK01415 632772002971 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 632772002972 active site residue [active] 632772002973 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 632772002974 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 632772002975 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632772002976 motif II; other site 632772002977 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 632772002978 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 632772002979 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 632772002980 substrate binding pocket [chemical binding]; other site 632772002981 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 632772002982 B12 binding site [chemical binding]; other site 632772002983 cobalt ligand [ion binding]; other site 632772002984 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 632772002985 PAC2 family; Region: PAC2; pfam09754 632772002986 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772002987 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632772002988 putative substrate translocation pore; other site 632772002989 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 632772002990 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 632772002991 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 632772002992 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 632772002993 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 632772002994 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 632772002995 iron-sulfur cluster [ion binding]; other site 632772002996 [2Fe-2S] cluster binding site [ion binding]; other site 632772002997 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 632772002998 Uncharacterized conserved protein [Function unknown]; Region: COG2128 632772002999 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 632772003000 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 632772003001 Helix-turn-helix domain; Region: HTH_18; pfam12833 632772003002 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632772003003 hypothetical protein; Provisional; Region: PRK07758 632772003004 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 632772003005 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 632772003006 non-specific DNA binding site [nucleotide binding]; other site 632772003007 salt bridge; other site 632772003008 sequence-specific DNA binding site [nucleotide binding]; other site 632772003009 Cupin domain; Region: Cupin_2; pfam07883 632772003010 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772003011 S-adenosylmethionine binding site [chemical binding]; other site 632772003012 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 632772003013 TIGR02677 family protein; Region: TIGR02677 632772003014 Protein of unknown function (DUF2398); Region: DUF2398; cl09875 632772003015 TIGR02680 family protein; Region: TIGR02680 632772003016 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 632772003017 cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Region: mycothiol_MshC; TIGR03447 632772003018 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 632772003019 active site 632772003020 HIGH motif; other site 632772003021 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 632772003022 active site 632772003023 KMSKS motif; other site 632772003024 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 632772003025 putative tRNA binding surface [nucleotide binding]; other site 632772003026 conserved hypothetical protein; Region: TIGR03843 632772003027 Protein of unknown function (DUF3090); Region: DUF3090; pfam11290 632772003028 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 632772003029 catalytic core [active] 632772003030 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 632772003031 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 632772003032 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 632772003033 active site 632772003034 catalytic tetrad [active] 632772003035 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 632772003036 heme binding pocket [chemical binding]; other site 632772003037 heme ligand [chemical binding]; other site 632772003038 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 632772003039 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 632772003040 intersubunit interface [polypeptide binding]; other site 632772003041 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 632772003042 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 632772003043 dimer interface [polypeptide binding]; other site 632772003044 putative PBP binding regions; other site 632772003045 ABC-ATPase subunit interface; other site 632772003046 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 632772003047 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 632772003048 Walker A/P-loop; other site 632772003049 ATP binding site [chemical binding]; other site 632772003050 Q-loop/lid; other site 632772003051 ABC transporter signature motif; other site 632772003052 Walker B; other site 632772003053 D-loop; other site 632772003054 H-loop/switch region; other site 632772003055 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 632772003056 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 632772003057 quinone interaction residues [chemical binding]; other site 632772003058 active site 632772003059 catalytic residues [active] 632772003060 FMN binding site [chemical binding]; other site 632772003061 substrate binding site [chemical binding]; other site 632772003062 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 632772003063 substrate binding site [chemical binding]; other site 632772003064 hypothetical protein; Provisional; Region: PRK07906 632772003065 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 632772003066 putative metal binding site [ion binding]; other site 632772003067 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772003068 NAD(P) binding site [chemical binding]; other site 632772003069 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 632772003070 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772003071 active site 632772003072 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 632772003073 Ligand Binding Site [chemical binding]; other site 632772003074 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 632772003075 Uncharacterized conserved protein [Function unknown]; Region: COG3268 632772003076 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 632772003077 NAD(P) binding pocket [chemical binding]; other site 632772003078 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 632772003079 malate synthase G; Provisional; Region: PRK02999 632772003080 active site 632772003081 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 632772003082 metal ion-dependent adhesion site (MIDAS); other site 632772003083 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 632772003084 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 632772003085 putative active site [active] 632772003086 putative metal binding site [ion binding]; other site 632772003087 glycine dehydrogenase; Provisional; Region: PRK05367 632772003088 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 632772003089 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 632772003090 catalytic residue [active] 632772003091 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 632772003092 tetramer interface [polypeptide binding]; other site 632772003093 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632772003094 catalytic residue [active] 632772003095 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 632772003096 DNA binding residues [nucleotide binding] 632772003097 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 632772003098 putative dimer interface [polypeptide binding]; other site 632772003099 Bifunctional nuclease; Region: DNase-RNase; pfam02577 632772003100 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 632772003101 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 632772003102 DNA binding residues [nucleotide binding] 632772003103 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 632772003104 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 632772003105 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 632772003106 phosphopeptide binding site; other site 632772003107 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 632772003108 lipoyl attachment site [posttranslational modification]; other site 632772003109 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 632772003110 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 632772003111 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 632772003112 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 632772003113 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 632772003114 Strictosidine synthase; Region: Str_synth; pfam03088 632772003115 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 632772003116 putative active site [active] 632772003117 putative CoA binding site [chemical binding]; other site 632772003118 nudix motif; other site 632772003119 metal binding site [ion binding]; metal-binding site 632772003120 acyl-CoA synthetase; Validated; Region: PRK06188 632772003121 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772003122 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 632772003123 acyl-activating enzyme (AAE) consensus motif; other site 632772003124 putative AMP binding site [chemical binding]; other site 632772003125 putative active site [active] 632772003126 putative CoA binding site [chemical binding]; other site 632772003127 Uncharacterized conserved protein [Function unknown]; Region: COG3268 632772003128 classical (c) SDRs; Region: SDR_c; cd05233 632772003129 NAD(P) binding site [chemical binding]; other site 632772003130 active site 632772003131 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772003132 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772003133 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 632772003134 hydrophobic ligand binding site; other site 632772003135 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 632772003136 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 632772003137 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 632772003138 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 632772003139 GTP-binding protein Der; Reviewed; Region: PRK03003 632772003140 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 632772003141 G1 box; other site 632772003142 GTP/Mg2+ binding site [chemical binding]; other site 632772003143 Switch I region; other site 632772003144 G2 box; other site 632772003145 Switch II region; other site 632772003146 G3 box; other site 632772003147 G4 box; other site 632772003148 G5 box; other site 632772003149 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 632772003150 G1 box; other site 632772003151 GTP/Mg2+ binding site [chemical binding]; other site 632772003152 Switch I region; other site 632772003153 G2 box; other site 632772003154 G3 box; other site 632772003155 Switch II region; other site 632772003156 G4 box; other site 632772003157 G5 box; other site 632772003158 cytidylate kinase; Provisional; Region: cmk; PRK00023 632772003159 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 632772003160 CMP-binding site; other site 632772003161 The sites determining sugar specificity; other site 632772003162 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 632772003163 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 632772003164 RNA binding surface [nucleotide binding]; other site 632772003165 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 632772003166 active site 632772003167 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 632772003168 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 632772003169 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 632772003170 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 632772003171 P-loop; other site 632772003172 Magnesium ion binding site [ion binding]; other site 632772003173 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 632772003174 Magnesium ion binding site [ion binding]; other site 632772003175 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 632772003176 dimer interface [polypeptide binding]; other site 632772003177 active site 632772003178 ADP-ribose binding site [chemical binding]; other site 632772003179 nudix motif; other site 632772003180 metal binding site [ion binding]; metal-binding site 632772003181 CTP synthetase; Validated; Region: pyrG; PRK05380 632772003182 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 632772003183 Catalytic site [active] 632772003184 active site 632772003185 UTP binding site [chemical binding]; other site 632772003186 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 632772003187 active site 632772003188 putative oxyanion hole; other site 632772003189 catalytic triad [active] 632772003190 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 632772003191 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 632772003192 Thiamine pyrophosphokinase; Region: TPK; cl08415 632772003193 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 632772003194 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 632772003195 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 632772003196 Walker A/P-loop; other site 632772003197 ATP binding site [chemical binding]; other site 632772003198 Q-loop/lid; other site 632772003199 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 632772003200 ABC transporter signature motif; other site 632772003201 Walker B; other site 632772003202 D-loop; other site 632772003203 H-loop/switch region; other site 632772003204 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 632772003205 ATP-NAD kinase; Region: NAD_kinase; pfam01513 632772003206 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 632772003207 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 632772003208 RNA binding surface [nucleotide binding]; other site 632772003209 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772003210 S-adenosylmethionine binding site [chemical binding]; other site 632772003211 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 632772003212 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632772003213 active site 632772003214 motif I; other site 632772003215 motif II; other site 632772003216 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 632772003217 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 632772003218 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 632772003219 active site 632772003220 HIGH motif; other site 632772003221 dimer interface [polypeptide binding]; other site 632772003222 KMSKS motif; other site 632772003223 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 632772003224 RNA binding surface [nucleotide binding]; other site 632772003225 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 632772003226 active site 632772003227 DNA binding site [nucleotide binding] 632772003228 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 632772003229 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 632772003230 Walker A/P-loop; other site 632772003231 ATP binding site [chemical binding]; other site 632772003232 Q-loop/lid; other site 632772003233 ABC transporter signature motif; other site 632772003234 Walker B; other site 632772003235 D-loop; other site 632772003236 H-loop/switch region; other site 632772003237 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 632772003238 ABC-2 type transporter; Region: ABC2_membrane; cl17235 632772003239 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772003240 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772003241 Uncharacterized conserved protein [Function unknown]; Region: COG2835 632772003242 acyl-CoA synthetase; Validated; Region: PRK07868 632772003243 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772003244 acyl-activating enzyme (AAE) consensus motif; other site 632772003245 active site 632772003246 AMP binding site [chemical binding]; other site 632772003247 CoA binding site [chemical binding]; other site 632772003248 argininosuccinate lyase; Provisional; Region: PRK00855 632772003249 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 632772003250 active sites [active] 632772003251 tetramer interface [polypeptide binding]; other site 632772003252 argininosuccinate synthase; Provisional; Region: PRK13820 632772003253 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 632772003254 ANP binding site [chemical binding]; other site 632772003255 Substrate Binding Site II [chemical binding]; other site 632772003256 Substrate Binding Site I [chemical binding]; other site 632772003257 Arginine repressor [Transcription]; Region: ArgR; COG1438 632772003258 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 632772003259 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 632772003260 ornithine carbamoyltransferase; Provisional; Region: PRK00779 632772003261 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 632772003262 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 632772003263 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 632772003264 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 632772003265 inhibitor-cofactor binding pocket; inhibition site 632772003266 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632772003267 catalytic residue [active] 632772003268 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 632772003269 feedback inhibition sensing region; other site 632772003270 homohexameric interface [polypeptide binding]; other site 632772003271 nucleotide binding site [chemical binding]; other site 632772003272 N-acetyl-L-glutamate binding site [chemical binding]; other site 632772003273 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 632772003274 heterotetramer interface [polypeptide binding]; other site 632772003275 active site pocket [active] 632772003276 cleavage site 632772003277 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 632772003278 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 632772003279 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 632772003280 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 632772003281 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 632772003282 putative tRNA-binding site [nucleotide binding]; other site 632772003283 B3/4 domain; Region: B3_4; pfam03483 632772003284 tRNA synthetase B5 domain; Region: B5; smart00874 632772003285 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 632772003286 dimer interface [polypeptide binding]; other site 632772003287 motif 1; other site 632772003288 motif 3; other site 632772003289 motif 2; other site 632772003290 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 632772003291 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 632772003292 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 632772003293 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 632772003294 dimer interface [polypeptide binding]; other site 632772003295 motif 1; other site 632772003296 active site 632772003297 motif 2; other site 632772003298 motif 3; other site 632772003299 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 632772003300 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 632772003301 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 632772003302 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 632772003303 23S rRNA binding site [nucleotide binding]; other site 632772003304 L21 binding site [polypeptide binding]; other site 632772003305 L13 binding site [polypeptide binding]; other site 632772003306 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 632772003307 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 632772003308 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 632772003309 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 632772003310 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 632772003311 HTH domain; Region: HTH_11; pfam08279 632772003312 WYL domain; Region: WYL; pfam13280 632772003313 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 632772003314 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 632772003315 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 632772003316 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 632772003317 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 632772003318 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 632772003319 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 632772003320 Predicted membrane protein [Function unknown]; Region: COG2259 632772003321 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 632772003322 Part of AAA domain; Region: AAA_19; pfam13245 632772003323 Family description; Region: UvrD_C_2; pfam13538 632772003324 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 632772003325 Ligand Binding Site [chemical binding]; other site 632772003326 excinuclease ABC subunit B; Provisional; Region: PRK05298 632772003327 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 632772003328 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 632772003329 nucleotide binding region [chemical binding]; other site 632772003330 ATP-binding site [chemical binding]; other site 632772003331 Ultra-violet resistance protein B; Region: UvrB; pfam12344 632772003332 UvrB/uvrC motif; Region: UVR; pfam02151 632772003333 Protein of unknown function (DUF402); Region: DUF402; cl00979 632772003334 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 632772003335 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 632772003336 CoA-binding site [chemical binding]; other site 632772003337 ATP-binding [chemical binding]; other site 632772003338 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 632772003339 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 632772003340 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 632772003341 RNA binding site [nucleotide binding]; other site 632772003342 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 632772003343 RNA binding site [nucleotide binding]; other site 632772003344 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 632772003345 RNA binding site [nucleotide binding]; other site 632772003346 S1 RNA binding domain; Region: S1; pfam00575 632772003347 RNA binding site [nucleotide binding]; other site 632772003348 Methyltransferase domain; Region: Methyltransf_31; pfam13847 632772003349 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772003350 S-adenosylmethionine binding site [chemical binding]; other site 632772003351 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 632772003352 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 632772003353 Walker A/P-loop; other site 632772003354 ATP binding site [chemical binding]; other site 632772003355 Q-loop/lid; other site 632772003356 ABC transporter signature motif; other site 632772003357 Walker B; other site 632772003358 D-loop; other site 632772003359 H-loop/switch region; other site 632772003360 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 632772003361 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772003362 dimer interface [polypeptide binding]; other site 632772003363 conserved gate region; other site 632772003364 putative PBP binding loops; other site 632772003365 ABC-ATPase subunit interface; other site 632772003366 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 632772003367 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 632772003368 substrate binding pocket [chemical binding]; other site 632772003369 membrane-bound complex binding site; other site 632772003370 hinge residues; other site 632772003371 tartrate dehydrogenase; Provisional; Region: PRK08194 632772003372 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 632772003373 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 632772003374 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 632772003375 EamA-like transporter family; Region: EamA; pfam00892 632772003376 EamA-like transporter family; Region: EamA; pfam00892 632772003377 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 632772003378 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 632772003379 conserved cys residue [active] 632772003380 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 632772003381 catalytic residues [active] 632772003382 DNA polymerase I; Provisional; Region: PRK05755 632772003383 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 632772003384 active site 632772003385 metal binding site 1 [ion binding]; metal-binding site 632772003386 putative 5' ssDNA interaction site; other site 632772003387 metal binding site 3; metal-binding site 632772003388 metal binding site 2 [ion binding]; metal-binding site 632772003389 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 632772003390 putative DNA binding site [nucleotide binding]; other site 632772003391 putative metal binding site [ion binding]; other site 632772003392 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 632772003393 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 632772003394 active site 632772003395 DNA binding site [nucleotide binding] 632772003396 catalytic site [active] 632772003397 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 632772003398 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 632772003399 TM-ABC transporter signature motif; other site 632772003400 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 632772003401 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 632772003402 TM-ABC transporter signature motif; other site 632772003403 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 632772003404 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 632772003405 Walker A/P-loop; other site 632772003406 ATP binding site [chemical binding]; other site 632772003407 Q-loop/lid; other site 632772003408 ABC transporter signature motif; other site 632772003409 Walker B; other site 632772003410 D-loop; other site 632772003411 H-loop/switch region; other site 632772003412 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 632772003413 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 632772003414 Walker A/P-loop; other site 632772003415 ATP binding site [chemical binding]; other site 632772003416 Q-loop/lid; other site 632772003417 ABC transporter signature motif; other site 632772003418 Walker B; other site 632772003419 D-loop; other site 632772003420 H-loop/switch region; other site 632772003421 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 632772003422 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 632772003423 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 632772003424 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632772003425 active site 632772003426 phosphorylation site [posttranslational modification] 632772003427 intermolecular recognition site; other site 632772003428 dimerization interface [polypeptide binding]; other site 632772003429 ANTAR domain; Region: ANTAR; pfam03861 632772003430 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 632772003431 Uncharacterized conserved protein [Function unknown]; Region: COG2128 632772003432 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 632772003433 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632772003434 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 632772003435 DNA binding residues [nucleotide binding] 632772003436 SnoaL-like domain; Region: SnoaL_2; pfam12680 632772003437 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 632772003438 putative hydrophobic ligand binding site [chemical binding]; other site 632772003439 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 632772003440 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 632772003441 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 632772003442 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 632772003443 Pyoverdine/dityrosine biosynthesis protein; Region: DIT1_PvcA; pfam05141 632772003444 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 632772003445 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 632772003446 active site 632772003447 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 632772003448 catalytic triad [active] 632772003449 dimer interface [polypeptide binding]; other site 632772003450 pyruvate kinase; Provisional; Region: PRK06247 632772003451 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 632772003452 domain interfaces; other site 632772003453 active site 632772003454 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 632772003455 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 632772003456 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 632772003457 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 632772003458 active site 632772003459 dimer interface [polypeptide binding]; other site 632772003460 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 632772003461 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 632772003462 active site 632772003463 FMN binding site [chemical binding]; other site 632772003464 substrate binding site [chemical binding]; other site 632772003465 3Fe-4S cluster binding site [ion binding]; other site 632772003466 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 632772003467 domain interface; other site 632772003468 TM2 domain; Region: TM2; pfam05154 632772003469 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 632772003470 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 632772003471 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 632772003472 substrate binding site [chemical binding]; other site 632772003473 active site 632772003474 catalytic residues [active] 632772003475 heterodimer interface [polypeptide binding]; other site 632772003476 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 632772003477 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 632772003478 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632772003479 catalytic residue [active] 632772003480 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 632772003481 active site 632772003482 ribulose/triose binding site [chemical binding]; other site 632772003483 phosphate binding site [ion binding]; other site 632772003484 substrate (anthranilate) binding pocket [chemical binding]; other site 632772003485 product (indole) binding pocket [chemical binding]; other site 632772003486 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 632772003487 anthranilate synthase component I; Provisional; Region: PRK13571 632772003488 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 632772003489 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 632772003490 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 632772003491 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 632772003492 catalytic triad [active] 632772003493 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 632772003494 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 632772003495 putative active site [active] 632772003496 metal binding site [ion binding]; metal-binding site 632772003497 MarR family; Region: MarR_2; cl17246 632772003498 Tautomerase enzyme; Region: Tautomerase; pfam01361 632772003499 active site 1 [active] 632772003500 dimer interface [polypeptide binding]; other site 632772003501 hexamer interface [polypeptide binding]; other site 632772003502 active site 2 [active] 632772003503 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 632772003504 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 632772003505 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 632772003506 substrate binding site [chemical binding]; other site 632772003507 glutamase interaction surface [polypeptide binding]; other site 632772003508 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 632772003509 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 632772003510 active site 632772003511 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 632772003512 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 632772003513 catalytic residues [active] 632772003514 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 632772003515 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 632772003516 putative active site [active] 632772003517 oxyanion strand; other site 632772003518 catalytic triad [active] 632772003519 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 632772003520 putative active site pocket [active] 632772003521 4-fold oligomerization interface [polypeptide binding]; other site 632772003522 metal binding residues [ion binding]; metal-binding site 632772003523 3-fold/trimer interface [polypeptide binding]; other site 632772003524 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 632772003525 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 632772003526 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632772003527 homodimer interface [polypeptide binding]; other site 632772003528 catalytic residue [active] 632772003529 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 632772003530 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 632772003531 NAD binding site [chemical binding]; other site 632772003532 dimerization interface [polypeptide binding]; other site 632772003533 product binding site; other site 632772003534 substrate binding site [chemical binding]; other site 632772003535 zinc binding site [ion binding]; other site 632772003536 catalytic residues [active] 632772003537 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772003538 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772003539 active site 632772003540 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 632772003541 beta-galactosidase; Region: BGL; TIGR03356 632772003542 LysE type translocator; Region: LysE; cl00565 632772003543 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 632772003544 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 632772003545 dimerization interface [polypeptide binding]; other site 632772003546 active site 632772003547 L-aspartate oxidase; Provisional; Region: PRK07804 632772003548 L-aspartate oxidase; Provisional; Region: PRK06175 632772003549 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 632772003550 quinolinate synthetase; Provisional; Region: PRK09375 632772003551 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 632772003552 nudix motif; other site 632772003553 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 632772003554 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772003555 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772003556 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772003557 WHG domain; Region: WHG; pfam13305 632772003558 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 632772003559 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772003560 NAD(P) binding site [chemical binding]; other site 632772003561 active site 632772003562 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 632772003563 biotin synthase; Validated; Region: PRK06256 632772003564 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632772003565 FeS/SAM binding site; other site 632772003566 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 632772003567 tetracycline repressor protein TetR; Provisional; Region: PRK13756 632772003568 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772003569 Secretory lipase; Region: LIP; pfam03583 632772003570 Transcriptional regulators [Transcription]; Region: FadR; COG2186 632772003571 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772003572 DNA-binding site [nucleotide binding]; DNA binding site 632772003573 FCD domain; Region: FCD; pfam07729 632772003574 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 632772003575 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 632772003576 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 632772003577 catalytic loop [active] 632772003578 iron binding site [ion binding]; other site 632772003579 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 632772003580 L-aspartate oxidase; Provisional; Region: PRK06175 632772003581 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 632772003582 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 632772003583 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 632772003584 active site 632772003585 metal binding site [ion binding]; metal-binding site 632772003586 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 632772003587 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 632772003588 active site 632772003589 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 632772003590 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 632772003591 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 632772003592 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 632772003593 catalytic residue [active] 632772003594 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 632772003595 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 632772003596 inhibitor-cofactor binding pocket; inhibition site 632772003597 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632772003598 catalytic residue [active] 632772003599 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 632772003600 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 632772003601 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 632772003602 active site 632772003603 catalytic site [active] 632772003604 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 632772003605 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 632772003606 active site 632772003607 catalytic site [active] 632772003608 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 632772003609 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 632772003610 putative NAD(P) binding site [chemical binding]; other site 632772003611 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772003612 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772003613 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 632772003614 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 632772003615 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 632772003616 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 632772003617 catalytic site [active] 632772003618 active site 632772003619 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 632772003620 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 632772003621 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772003622 putative substrate translocation pore; other site 632772003623 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772003624 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772003625 threonine dehydratase; Validated; Region: PRK08639 632772003626 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 632772003627 tetramer interface [polypeptide binding]; other site 632772003628 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632772003629 catalytic residue [active] 632772003630 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 632772003631 pyruvate dehydrogenase; Provisional; Region: PRK06546 632772003632 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 632772003633 PYR/PP interface [polypeptide binding]; other site 632772003634 dimer interface [polypeptide binding]; other site 632772003635 tetramer interface [polypeptide binding]; other site 632772003636 TPP binding site [chemical binding]; other site 632772003637 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 632772003638 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 632772003639 TPP-binding site [chemical binding]; other site 632772003640 Domain of unknown function (DUF385); Region: DUF385; pfam04075 632772003641 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 632772003642 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 632772003643 active site 632772003644 PHP Thumb interface [polypeptide binding]; other site 632772003645 metal binding site [ion binding]; metal-binding site 632772003646 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 632772003647 generic binding surface II; other site 632772003648 generic binding surface I; other site 632772003649 Predicted permeases [General function prediction only]; Region: RarD; COG2962 632772003650 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 632772003651 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 632772003652 RNA binding surface [nucleotide binding]; other site 632772003653 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 632772003654 active site 632772003655 lipoprotein signal peptidase; Provisional; Region: PRK14764 632772003656 PknH-like extracellular domain; Region: PknH_C; pfam14032 632772003657 DNA polymerase IV; Provisional; Region: PRK03348 632772003658 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 632772003659 active site 632772003660 DNA binding site [nucleotide binding] 632772003661 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 632772003662 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 632772003663 HIGH motif; other site 632772003664 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 632772003665 active site 632772003666 KMSKS motif; other site 632772003667 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 632772003668 tRNA binding surface [nucleotide binding]; other site 632772003669 anticodon binding site; other site 632772003670 DivIVA protein; Region: DivIVA; pfam05103 632772003671 DivIVA domain; Region: DivI1A_domain; TIGR03544 632772003672 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 632772003673 Predicted integral membrane protein [Function unknown]; Region: COG0762 632772003674 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 632772003675 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 632772003676 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 632772003677 catalytic residue [active] 632772003678 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 632772003679 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 632772003680 cell division protein FtsZ; Validated; Region: PRK09330 632772003681 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 632772003682 nucleotide binding site [chemical binding]; other site 632772003683 SulA interaction site; other site 632772003684 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 632772003685 Cell division protein FtsQ; Region: FtsQ; pfam03799 632772003686 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 632772003687 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 632772003688 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 632772003689 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 632772003690 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 632772003691 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 632772003692 active site 632772003693 homodimer interface [polypeptide binding]; other site 632772003694 cell division protein FtsW; Region: ftsW; TIGR02614 632772003695 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 632772003696 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 632772003697 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 632772003698 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 632772003699 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 632772003700 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 632772003701 Mg++ binding site [ion binding]; other site 632772003702 putative catalytic motif [active] 632772003703 putative substrate binding site [chemical binding]; other site 632772003704 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 632772003705 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 632772003706 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 632772003707 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 632772003708 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 632772003709 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 632772003710 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 632772003711 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 632772003712 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 632772003713 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 632772003714 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 632772003715 MraW methylase family; Region: Methyltransf_5; cl17771 632772003716 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 632772003717 cell division protein MraZ; Reviewed; Region: PRK00326 632772003718 MraZ protein; Region: MraZ; pfam02381 632772003719 MraZ protein; Region: MraZ; pfam02381 632772003720 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 632772003721 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 632772003722 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 632772003723 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 632772003724 Protein of unknown function (DUF422); Region: DUF422; cl00991 632772003725 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 632772003726 active site 632772003727 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 632772003728 FAD binding site [chemical binding]; other site 632772003729 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 632772003730 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 632772003731 substrate binding pocket [chemical binding]; other site 632772003732 chain length determination region; other site 632772003733 substrate-Mg2+ binding site; other site 632772003734 catalytic residues [active] 632772003735 aspartate-rich region 1; other site 632772003736 active site lid residues [active] 632772003737 aspartate-rich region 2; other site 632772003738 phytoene desaturase; Region: crtI_fam; TIGR02734 632772003739 hydroxyglutarate oxidase; Provisional; Region: PRK11728 632772003740 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 632772003741 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 632772003742 active site lid residues [active] 632772003743 substrate binding pocket [chemical binding]; other site 632772003744 catalytic residues [active] 632772003745 substrate-Mg2+ binding site; other site 632772003746 aspartate-rich region 1; other site 632772003747 aspartate-rich region 2; other site 632772003748 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 632772003749 Catalytic domain of Protein Kinases; Region: PKc; cd00180 632772003750 active site 632772003751 ATP binding site [chemical binding]; other site 632772003752 substrate binding site [chemical binding]; other site 632772003753 activation loop (A-loop); other site 632772003754 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 632772003755 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 632772003756 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 632772003757 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 632772003758 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 632772003759 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 632772003760 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 632772003761 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 632772003762 putative acyl-acceptor binding pocket; other site 632772003763 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 632772003764 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 632772003765 nucleotide binding site [chemical binding]; other site 632772003766 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 632772003767 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 632772003768 P loop; other site 632772003769 Nucleotide binding site [chemical binding]; other site 632772003770 DTAP/Switch II; other site 632772003771 Switch I; other site 632772003772 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 632772003773 putative hydrophobic ligand binding site [chemical binding]; other site 632772003774 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 632772003775 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772003776 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 632772003777 acyl-activating enzyme (AAE) consensus motif; other site 632772003778 putative AMP binding site [chemical binding]; other site 632772003779 putative active site [active] 632772003780 putative CoA binding site [chemical binding]; other site 632772003781 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 632772003782 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 632772003783 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 632772003784 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 632772003785 NlpC/P60 family; Region: NLPC_P60; pfam00877 632772003786 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 632772003787 NlpC/P60 family; Region: NLPC_P60; pfam00877 632772003788 hypothetical protein; Validated; Region: PRK07883 632772003789 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 632772003790 active site 632772003791 catalytic site [active] 632772003792 substrate binding site [chemical binding]; other site 632772003793 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 632772003794 GIY-YIG motif/motif A; other site 632772003795 active site 632772003796 catalytic site [active] 632772003797 putative DNA binding site [nucleotide binding]; other site 632772003798 metal binding site [ion binding]; metal-binding site 632772003799 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 632772003800 AsnC family; Region: AsnC_trans_reg; pfam01037 632772003801 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 632772003802 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 632772003803 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 632772003804 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 632772003805 Subunit I/III interface [polypeptide binding]; other site 632772003806 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 632772003807 Cytochrome c; Region: Cytochrom_C; cl11414 632772003808 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 632772003809 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 632772003810 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 632772003811 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 632772003812 iron-sulfur cluster [ion binding]; other site 632772003813 [2Fe-2S] cluster binding site [ion binding]; other site 632772003814 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 632772003815 heme bH binding site [chemical binding]; other site 632772003816 intrachain domain interface; other site 632772003817 heme bL binding site [chemical binding]; other site 632772003818 interchain domain interface [polypeptide binding]; other site 632772003819 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 632772003820 Qo binding site; other site 632772003821 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 632772003822 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 632772003823 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 632772003824 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 632772003825 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 632772003826 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 632772003827 dimer interface [polypeptide binding]; other site 632772003828 active site 632772003829 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 632772003830 Ligand Binding Site [chemical binding]; other site 632772003831 Molecular Tunnel; other site 632772003832 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 632772003833 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 632772003834 substrate binding site [chemical binding]; other site 632772003835 ATP binding site [chemical binding]; other site 632772003836 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 632772003837 Glycerate kinase family; Region: Gly_kinase; cl00841 632772003838 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 632772003839 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 632772003840 homotrimer interface [polypeptide binding]; other site 632772003841 Walker A motif; other site 632772003842 GTP binding site [chemical binding]; other site 632772003843 Walker B motif; other site 632772003844 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 632772003845 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 632772003846 putative dimer interface [polypeptide binding]; other site 632772003847 active site pocket [active] 632772003848 putative cataytic base [active] 632772003849 cobalamin synthase; Reviewed; Region: cobS; PRK00235 632772003850 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 632772003851 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 632772003852 homodimer interface [polypeptide binding]; other site 632772003853 substrate-cofactor binding pocket; other site 632772003854 catalytic residue [active] 632772003855 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 632772003856 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 632772003857 multifunctional aminopeptidase A; Provisional; Region: PRK00913 632772003858 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 632772003859 interface (dimer of trimers) [polypeptide binding]; other site 632772003860 Substrate-binding/catalytic site; other site 632772003861 Zn-binding sites [ion binding]; other site 632772003862 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; Region: SucB_Actino; TIGR02927 632772003863 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 632772003864 E3 interaction surface; other site 632772003865 lipoyl attachment site [posttranslational modification]; other site 632772003866 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 632772003867 E3 interaction surface; other site 632772003868 lipoyl attachment site [posttranslational modification]; other site 632772003869 e3 binding domain; Region: E3_binding; pfam02817 632772003870 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 632772003871 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 632772003872 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 632772003873 putative NAD(P) binding site [chemical binding]; other site 632772003874 putative active site [active] 632772003875 lipoate-protein ligase B; Provisional; Region: PRK14345 632772003876 lipoyl synthase; Provisional; Region: PRK05481 632772003877 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632772003878 FeS/SAM binding site; other site 632772003879 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 632772003880 RDD family; Region: RDD; pfam06271 632772003881 glutamine synthetase, type I; Region: GlnA; TIGR00653 632772003882 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 632772003883 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 632772003884 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772003885 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632772003886 putative substrate translocation pore; other site 632772003887 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 632772003888 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 632772003889 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772003890 putative PBP binding loops; other site 632772003891 dimer interface [polypeptide binding]; other site 632772003892 ABC-ATPase subunit interface; other site 632772003893 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 632772003894 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 632772003895 Walker A/P-loop; other site 632772003896 ATP binding site [chemical binding]; other site 632772003897 Q-loop/lid; other site 632772003898 ABC transporter signature motif; other site 632772003899 Walker B; other site 632772003900 D-loop; other site 632772003901 H-loop/switch region; other site 632772003902 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772003903 dimer interface [polypeptide binding]; other site 632772003904 conserved gate region; other site 632772003905 putative PBP binding loops; other site 632772003906 ABC-ATPase subunit interface; other site 632772003907 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 632772003908 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 632772003909 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 632772003910 putative catalytic site [active] 632772003911 putative metal binding site [ion binding]; other site 632772003912 putative phosphate binding site [ion binding]; other site 632772003913 putative catalytic site [active] 632772003914 putative phosphate binding site [ion binding]; other site 632772003915 putative metal binding site [ion binding]; other site 632772003916 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 632772003917 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 632772003918 metal binding triad; other site 632772003919 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 632772003920 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 632772003921 metal binding triad [ion binding]; metal-binding site 632772003922 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 632772003923 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 632772003924 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 632772003925 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 632772003926 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 632772003927 TAP-like protein; Region: Abhydrolase_4; pfam08386 632772003928 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 632772003929 oligomerization interface [polypeptide binding]; other site 632772003930 active site 632772003931 metal binding site [ion binding]; metal-binding site 632772003932 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 632772003933 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 632772003934 TAP-like protein; Region: Abhydrolase_4; pfam08386 632772003935 RNB domain; Region: RNB; pfam00773 632772003936 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 632772003937 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 632772003938 active site 632772003939 catalytic site [active] 632772003940 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 632772003941 active site 2 [active] 632772003942 active site 1 [active] 632772003943 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 632772003944 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 632772003945 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 632772003946 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 632772003947 transmembrane helices; other site 632772003948 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 632772003949 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 632772003950 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 632772003951 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 632772003952 RNA/DNA hybrid binding site [nucleotide binding]; other site 632772003953 active site 632772003954 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 632772003955 catalytic core [active] 632772003956 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 632772003957 Putative zinc ribbon domain; Region: DUF164; pfam02591 632772003958 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 632772003959 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 632772003960 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 632772003961 hypothetical protein; Provisional; Region: PRK07908 632772003962 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 632772003963 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632772003964 homodimer interface [polypeptide binding]; other site 632772003965 catalytic residue [active] 632772003966 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 632772003967 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632772003968 motif II; other site 632772003969 Low molecular weight phosphatase family; Region: LMWPc; cd00115 632772003970 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 632772003971 active site 632772003972 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 632772003973 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 632772003974 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 632772003975 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 632772003976 dimer interface [polypeptide binding]; other site 632772003977 catalytic triad [active] 632772003978 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 632772003979 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 632772003980 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 632772003981 dimer interface [polypeptide binding]; other site 632772003982 TPP-binding site [chemical binding]; other site 632772003983 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 632772003984 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 632772003985 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 632772003986 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 632772003987 acyl carrier protein; Provisional; Region: acpP; PRK00982 632772003988 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 632772003989 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 632772003990 dimer interface [polypeptide binding]; other site 632772003991 active site 632772003992 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 632772003993 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 632772003994 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835 632772003995 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 632772003996 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 632772003997 Beta-lactamase; Region: Beta-lactamase; pfam00144 632772003998 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 632772003999 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 632772004000 NAD binding site [chemical binding]; other site 632772004001 catalytic Zn binding site [ion binding]; other site 632772004002 substrate binding site [chemical binding]; other site 632772004003 structural Zn binding site [ion binding]; other site 632772004004 Adenosine specific kinase; Region: Adenosine_kin; pfam04008 632772004005 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 632772004006 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 632772004007 Domain of unknown function DUF20; Region: UPF0118; pfam01594 632772004008 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 632772004009 DNA primase; Validated; Region: dnaG; PRK05667 632772004010 CHC2 zinc finger; Region: zf-CHC2; cl17510 632772004011 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 632772004012 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 632772004013 active site 632772004014 metal binding site [ion binding]; metal-binding site 632772004015 interdomain interaction site; other site 632772004016 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 632772004017 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 632772004018 Secretory lipase; Region: LIP; pfam03583 632772004019 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 632772004020 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 632772004021 Zn2+ binding site [ion binding]; other site 632772004022 Mg2+ binding site [ion binding]; other site 632772004023 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 632772004024 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 632772004025 putative active site [active] 632772004026 Repair protein; Region: Repair_PSII; pfam04536 632772004027 glycyl-tRNA synthetase; Provisional; Region: PRK04173 632772004028 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 632772004029 motif 1; other site 632772004030 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 632772004031 active site 632772004032 motif 2; other site 632772004033 motif 3; other site 632772004034 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 632772004035 anticodon binding site; other site 632772004036 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632772004037 dimerization interface [polypeptide binding]; other site 632772004038 putative DNA binding site [nucleotide binding]; other site 632772004039 putative Zn2+ binding site [ion binding]; other site 632772004040 ferric uptake regulator; Provisional; Region: fur; PRK09462 632772004041 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 632772004042 metal binding site 2 [ion binding]; metal-binding site 632772004043 putative DNA binding helix; other site 632772004044 metal binding site 1 [ion binding]; metal-binding site 632772004045 dimer interface [polypeptide binding]; other site 632772004046 structural Zn2+ binding site [ion binding]; other site 632772004047 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 632772004048 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 632772004049 catalytic residue [active] 632772004050 putative FPP diphosphate binding site; other site 632772004051 putative FPP binding hydrophobic cleft; other site 632772004052 dimer interface [polypeptide binding]; other site 632772004053 putative IPP diphosphate binding site; other site 632772004054 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 632772004055 Recombination protein O N terminal; Region: RecO_N; pfam11967 632772004056 Recombination protein O C terminal; Region: RecO_C; pfam02565 632772004057 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 632772004058 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 632772004059 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 632772004060 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 632772004061 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 632772004062 siderophore binding site; other site 632772004063 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 632772004064 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632772004065 active site 632772004066 phosphorylation site [posttranslational modification] 632772004067 intermolecular recognition site; other site 632772004068 dimerization interface [polypeptide binding]; other site 632772004069 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 632772004070 DNA binding site [nucleotide binding] 632772004071 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 632772004072 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 632772004073 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 632772004074 Ligand Binding Site [chemical binding]; other site 632772004075 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 632772004076 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 632772004077 dimer interface [polypeptide binding]; other site 632772004078 phosphorylation site [posttranslational modification] 632772004079 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632772004080 ATP binding site [chemical binding]; other site 632772004081 Mg2+ binding site [ion binding]; other site 632772004082 G-X-G motif; other site 632772004083 K+-transporting ATPase, c chain; Region: KdpC; cl00944 632772004084 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 632772004085 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 632772004086 Soluble P-type ATPase [General function prediction only]; Region: COG4087 632772004087 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 632772004088 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 632772004089 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 632772004090 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772004091 DNA-binding site [nucleotide binding]; DNA binding site 632772004092 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 632772004093 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632772004094 homodimer interface [polypeptide binding]; other site 632772004095 catalytic residue [active] 632772004096 amidase; Provisional; Region: PRK06061 632772004097 Amidase; Region: Amidase; cl11426 632772004098 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772004099 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772004100 GTPase Era; Reviewed; Region: era; PRK00089 632772004101 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 632772004102 G1 box; other site 632772004103 GTP/Mg2+ binding site [chemical binding]; other site 632772004104 Switch I region; other site 632772004105 G2 box; other site 632772004106 Switch II region; other site 632772004107 G3 box; other site 632772004108 G4 box; other site 632772004109 G5 box; other site 632772004110 KH domain; Region: KH_2; pfam07650 632772004111 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 632772004112 Domain of unknown function DUF21; Region: DUF21; pfam01595 632772004113 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 632772004114 Transporter associated domain; Region: CorC_HlyC; smart01091 632772004115 metal-binding heat shock protein; Provisional; Region: PRK00016 632772004116 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl17245 632772004117 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 632772004118 PhoH-like protein; Region: PhoH; pfam02562 632772004119 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 632772004120 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 632772004121 RNA methyltransferase, RsmE family; Region: TIGR00046 632772004122 chaperone protein DnaJ; Provisional; Region: PRK14278 632772004123 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 632772004124 HSP70 interaction site [polypeptide binding]; other site 632772004125 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 632772004126 Zn binding sites [ion binding]; other site 632772004127 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 632772004128 dimer interface [polypeptide binding]; other site 632772004129 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 632772004130 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 632772004131 coproporphyrinogen III oxidase; Validated; Region: PRK05628 632772004132 HemN C-terminal domain; Region: HemN_C; pfam06969 632772004133 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 632772004134 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 632772004135 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 632772004136 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 632772004137 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 632772004138 Active Sites [active] 632772004139 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 632772004140 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 632772004141 Active Sites [active] 632772004142 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 632772004143 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 632772004144 CysD dimerization site [polypeptide binding]; other site 632772004145 G1 box; other site 632772004146 putative GEF interaction site [polypeptide binding]; other site 632772004147 GTP/Mg2+ binding site [chemical binding]; other site 632772004148 Switch I region; other site 632772004149 G2 box; other site 632772004150 G3 box; other site 632772004151 Switch II region; other site 632772004152 G4 box; other site 632772004153 G5 box; other site 632772004154 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 632772004155 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 632772004156 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 632772004157 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 632772004158 putative active site [active] 632772004159 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 632772004160 putative active site [active] 632772004161 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 632772004162 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 632772004163 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632772004164 homodimer interface [polypeptide binding]; other site 632772004165 catalytic residue [active] 632772004166 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 632772004167 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 632772004168 active site 632772004169 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 632772004170 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 632772004171 PYR/PP interface [polypeptide binding]; other site 632772004172 dimer interface [polypeptide binding]; other site 632772004173 TPP binding site [chemical binding]; other site 632772004174 potential frameshift: common BLAST hit: gi|111018269|ref|YP_701241.1| acetolactate synthase 632772004175 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 632772004176 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 632772004177 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 632772004178 TPP-binding site [chemical binding]; other site 632772004179 Putative zinc-finger; Region: zf-HC2; pfam13490 632772004180 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 632772004181 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632772004182 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 632772004183 DNA binding residues [nucleotide binding] 632772004184 Uncharacterized conserved protein [Function unknown]; Region: COG5649 632772004185 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 632772004186 Ligand Binding Site [chemical binding]; other site 632772004187 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 632772004188 Ligand Binding Site [chemical binding]; other site 632772004189 Stf0 sulphotransferase; Region: Sulphotransf; pfam09037 632772004190 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 632772004191 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 632772004192 Active Sites [active] 632772004193 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 632772004194 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 632772004195 CysD dimerization site [polypeptide binding]; other site 632772004196 G1 box; other site 632772004197 putative GEF interaction site [polypeptide binding]; other site 632772004198 GTP/Mg2+ binding site [chemical binding]; other site 632772004199 Switch I region; other site 632772004200 G2 box; other site 632772004201 G3 box; other site 632772004202 Switch II region; other site 632772004203 G4 box; other site 632772004204 G5 box; other site 632772004205 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 632772004206 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 632772004207 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 632772004208 ligand-binding site [chemical binding]; other site 632772004209 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 632772004210 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 632772004211 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 632772004212 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 632772004213 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 632772004214 Sulfatase; Region: Sulfatase; pfam00884 632772004215 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 632772004216 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 632772004217 Walker A/P-loop; other site 632772004218 ATP binding site [chemical binding]; other site 632772004219 Q-loop/lid; other site 632772004220 ABC transporter signature motif; other site 632772004221 Walker B; other site 632772004222 D-loop; other site 632772004223 H-loop/switch region; other site 632772004224 TOBE domain; Region: TOBE; pfam03459 632772004225 sulfate transport protein; Provisional; Region: cysT; CHL00187 632772004226 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772004227 dimer interface [polypeptide binding]; other site 632772004228 conserved gate region; other site 632772004229 putative PBP binding loops; other site 632772004230 ABC-ATPase subunit interface; other site 632772004231 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 632772004232 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772004233 dimer interface [polypeptide binding]; other site 632772004234 conserved gate region; other site 632772004235 putative PBP binding loops; other site 632772004236 ABC-ATPase subunit interface; other site 632772004237 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 632772004238 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 632772004239 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 632772004240 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 632772004241 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 632772004242 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 632772004243 intersubunit interface [polypeptide binding]; other site 632772004244 Nitronate monooxygenase; Region: NMO; pfam03060 632772004245 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 632772004246 FMN binding site [chemical binding]; other site 632772004247 substrate binding site [chemical binding]; other site 632772004248 putative catalytic residue [active] 632772004249 GTP-binding protein LepA; Provisional; Region: PRK05433 632772004250 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 632772004251 G1 box; other site 632772004252 putative GEF interaction site [polypeptide binding]; other site 632772004253 GTP/Mg2+ binding site [chemical binding]; other site 632772004254 Switch I region; other site 632772004255 G2 box; other site 632772004256 G3 box; other site 632772004257 Switch II region; other site 632772004258 G4 box; other site 632772004259 G5 box; other site 632772004260 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 632772004261 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 632772004262 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 632772004263 PemK-like protein; Region: PemK; pfam02452 632772004264 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 632772004265 active site 632772004266 catalytic triad [active] 632772004267 oxyanion hole [active] 632772004268 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 632772004269 amphipathic channel; other site 632772004270 Asn-Pro-Ala signature motifs; other site 632772004271 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 632772004272 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 632772004273 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 632772004274 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 632772004275 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 632772004276 Uncharacterized conserved protein [Function unknown]; Region: COG2308 632772004277 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 632772004278 hypothetical protein; Reviewed; Region: PRK07914 632772004279 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 632772004280 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 632772004281 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 632772004282 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 632772004283 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 632772004284 substrate binding pocket [chemical binding]; other site 632772004285 catalytic triad [active] 632772004286 ANTAR domain; Region: ANTAR; pfam03861 632772004287 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 632772004288 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 632772004289 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 632772004290 Competence protein; Region: Competence; pfam03772 632772004291 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 632772004292 Helix-hairpin-helix motif; Region: HHH; pfam00633 632772004293 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 632772004294 EDD domain protein, DegV family; Region: DegV; TIGR00762 632772004295 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 632772004296 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 632772004297 active site 632772004298 catalytic triad [active] 632772004299 oxyanion hole [active] 632772004300 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 632772004301 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 632772004302 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 632772004303 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 632772004304 active site 632772004305 (T/H)XGH motif; other site 632772004306 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 632772004307 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 632772004308 metal ion-dependent adhesion site (MIDAS); other site 632772004309 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632772004310 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 632772004311 Walker A motif; other site 632772004312 ATP binding site [chemical binding]; other site 632772004313 Walker B motif; other site 632772004314 arginine finger; other site 632772004315 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 632772004316 putative catalytic cysteine [active] 632772004317 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 632772004318 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 632772004319 active site 632772004320 FMN binding site [chemical binding]; other site 632772004321 substrate binding site [chemical binding]; other site 632772004322 homotetramer interface [polypeptide binding]; other site 632772004323 catalytic residue [active] 632772004324 proline/glycine betaine transporter; Provisional; Region: PRK10642 632772004325 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772004326 putative substrate translocation pore; other site 632772004327 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 632772004328 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 632772004329 substrate binding site [chemical binding]; other site 632772004330 ATP binding site [chemical binding]; other site 632772004331 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 632772004332 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 632772004333 ATP binding site [chemical binding]; other site 632772004334 putative Mg++ binding site [ion binding]; other site 632772004335 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 632772004336 nucleotide binding region [chemical binding]; other site 632772004337 ATP-binding site [chemical binding]; other site 632772004338 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 632772004339 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 632772004340 Coenzyme A binding pocket [chemical binding]; other site 632772004341 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 632772004342 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 632772004343 inhibitor-cofactor binding pocket; inhibition site 632772004344 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632772004345 catalytic residue [active] 632772004346 L-ectoine synthase; Reviewed; Region: ectC; PRK13290 632772004347 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159 632772004348 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 632772004349 putative ligand binding site [chemical binding]; other site 632772004350 putative NAD binding site [chemical binding]; other site 632772004351 catalytic site [active] 632772004352 NAD-dependent deacetylase; Provisional; Region: PRK14138 632772004353 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 632772004354 NAD+ binding site [chemical binding]; other site 632772004355 substrate binding site [chemical binding]; other site 632772004356 Zn binding site [ion binding]; other site 632772004357 gamma-glutamyl kinase; Provisional; Region: PRK05429 632772004358 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 632772004359 nucleotide binding site [chemical binding]; other site 632772004360 homotetrameric interface [polypeptide binding]; other site 632772004361 putative phosphate binding site [ion binding]; other site 632772004362 putative allosteric binding site; other site 632772004363 PUA domain; Region: PUA; pfam01472 632772004364 GTPase CgtA; Reviewed; Region: obgE; PRK12296 632772004365 GTP1/OBG; Region: GTP1_OBG; pfam01018 632772004366 Obg GTPase; Region: Obg; cd01898 632772004367 G1 box; other site 632772004368 GTP/Mg2+ binding site [chemical binding]; other site 632772004369 Switch I region; other site 632772004370 G2 box; other site 632772004371 G3 box; other site 632772004372 Switch II region; other site 632772004373 G4 box; other site 632772004374 G5 box; other site 632772004375 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 632772004376 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 632772004377 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 632772004378 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 632772004379 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 632772004380 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 632772004381 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 632772004382 homodimer interface [polypeptide binding]; other site 632772004383 oligonucleotide binding site [chemical binding]; other site 632772004384 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 632772004385 active site 632772004386 multimer interface [polypeptide binding]; other site 632772004387 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 632772004388 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 632772004389 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 632772004390 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 632772004391 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 632772004392 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 632772004393 active site 632772004394 HIGH motif; other site 632772004395 nucleotide binding site [chemical binding]; other site 632772004396 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 632772004397 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 632772004398 active site 632772004399 KMSKS motif; other site 632772004400 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 632772004401 tRNA binding surface [nucleotide binding]; other site 632772004402 anticodon binding site; other site 632772004403 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 632772004404 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_5; cd08898 632772004405 putative hydrophobic ligand binding site [chemical binding]; other site 632772004406 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 632772004407 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 632772004408 active site 632772004409 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 632772004410 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 632772004411 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 632772004412 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 632772004413 siderophore binding site; other site 632772004414 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 632772004415 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 632772004416 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 632772004417 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 632772004418 active site 632772004419 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 632772004420 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 632772004421 heterodimer interface [polypeptide binding]; other site 632772004422 active site 632772004423 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 632772004424 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 632772004425 tetramer interface [polypeptide binding]; other site 632772004426 active site 632772004427 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 632772004428 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 632772004429 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 632772004430 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 632772004431 Bacterial transcriptional regulator; Region: IclR; pfam01614 632772004432 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 632772004433 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 632772004434 dimer interface [polypeptide binding]; other site 632772004435 active site 632772004436 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 632772004437 active site 632772004438 metal binding site [ion binding]; metal-binding site 632772004439 homotetramer interface [polypeptide binding]; other site 632772004440 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 632772004441 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 632772004442 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 632772004443 shikimate binding site; other site 632772004444 NAD(P) binding site [chemical binding]; other site 632772004445 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772004446 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772004447 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772004448 metabolite-proton symporter; Region: 2A0106; TIGR00883 632772004449 putative substrate translocation pore; other site 632772004450 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 632772004451 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 632772004452 Walker A/P-loop; other site 632772004453 ATP binding site [chemical binding]; other site 632772004454 Q-loop/lid; other site 632772004455 ABC transporter signature motif; other site 632772004456 Walker B; other site 632772004457 D-loop; other site 632772004458 H-loop/switch region; other site 632772004459 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 632772004460 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 632772004461 TM-ABC transporter signature motif; other site 632772004462 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 632772004463 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 632772004464 putative ligand binding site [chemical binding]; other site 632772004465 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772004466 putative substrate translocation pore; other site 632772004467 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 632772004468 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772004469 DNA-binding site [nucleotide binding]; DNA binding site 632772004470 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 632772004471 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 632772004472 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 632772004473 substrate binding site [chemical binding]; other site 632772004474 ATP binding site [chemical binding]; other site 632772004475 KduI/IolB family; Region: KduI; pfam04962 632772004476 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 632772004477 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 632772004478 PYR/PP interface [polypeptide binding]; other site 632772004479 dimer interface [polypeptide binding]; other site 632772004480 TPP binding site [chemical binding]; other site 632772004481 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 632772004482 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 632772004483 TPP-binding site; other site 632772004484 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 632772004485 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 632772004486 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 632772004487 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 632772004488 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 632772004489 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 632772004490 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 632772004491 tetrameric interface [polypeptide binding]; other site 632772004492 NAD binding site [chemical binding]; other site 632772004493 catalytic residues [active] 632772004494 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 632772004495 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 632772004496 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 632772004497 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 632772004498 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 632772004499 nucleotide binding site [chemical binding]; other site 632772004500 Domain of unknown function (DUF222); Region: DUF222; pfam02720 632772004501 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 632772004502 active site 632772004503 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 632772004504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772004505 putative substrate translocation pore; other site 632772004506 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772004507 Transcriptional regulators [Transcription]; Region: PurR; COG1609 632772004508 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 632772004509 DNA binding site [nucleotide binding] 632772004510 domain linker motif; other site 632772004511 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 632772004512 dimerization interface [polypeptide binding]; other site 632772004513 ligand binding site [chemical binding]; other site 632772004514 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 632772004515 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 632772004516 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 632772004517 Transcriptional regulators [Transcription]; Region: PurR; COG1609 632772004518 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 632772004519 DNA binding site [nucleotide binding] 632772004520 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 632772004521 putative ligand binding site [chemical binding]; other site 632772004522 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 632772004523 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 632772004524 Peptidase family M23; Region: Peptidase_M23; pfam01551 632772004525 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 632772004526 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 632772004527 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 632772004528 active site 632772004529 Fe binding site [ion binding]; other site 632772004530 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 632772004531 Dehydroquinase class II; Region: DHquinase_II; pfam01220 632772004532 trimer interface [polypeptide binding]; other site 632772004533 active site 632772004534 dimer interface [polypeptide binding]; other site 632772004535 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 632772004536 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 632772004537 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632772004538 Walker A motif; other site 632772004539 ATP binding site [chemical binding]; other site 632772004540 Walker B motif; other site 632772004541 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 632772004542 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 632772004543 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 632772004544 oligomer interface [polypeptide binding]; other site 632772004545 active site residues [active] 632772004546 Clp protease; Region: CLP_protease; pfam00574 632772004547 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 632772004548 oligomer interface [polypeptide binding]; other site 632772004549 active site residues [active] 632772004550 trigger factor; Provisional; Region: tig; PRK01490 632772004551 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 632772004552 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 632772004553 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 632772004554 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 632772004555 putative DNA binding site [nucleotide binding]; other site 632772004556 catalytic residue [active] 632772004557 putative H2TH interface [polypeptide binding]; other site 632772004558 putative catalytic residues [active] 632772004559 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 632772004560 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 632772004561 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 632772004562 Peptidase family M48; Region: Peptidase_M48; pfam01435 632772004563 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 632772004564 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 632772004565 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 632772004566 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 632772004567 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 632772004568 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 632772004569 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 632772004570 Zn binding site [ion binding]; other site 632772004571 DNA polymerase IV; Validated; Region: PRK03858 632772004572 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 632772004573 active site 632772004574 DNA binding site [nucleotide binding] 632772004575 Helix-turn-helix domain; Region: HTH_18; pfam12833 632772004576 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 632772004577 putative hydrophobic ligand binding site [chemical binding]; other site 632772004578 protein interface [polypeptide binding]; other site 632772004579 gate; other site 632772004580 Repair protein; Region: Repair_PSII; pfam04536 632772004581 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 632772004582 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 632772004583 active site 632772004584 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 632772004585 apolar tunnel; other site 632772004586 heme binding site [chemical binding]; other site 632772004587 dimerization interface [polypeptide binding]; other site 632772004588 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 632772004589 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 632772004590 active site 632772004591 catalytic site [active] 632772004592 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 632772004593 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 632772004594 active site 632772004595 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 632772004596 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 632772004597 active site 632772004598 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 632772004599 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632772004600 Walker A/P-loop; other site 632772004601 ATP binding site [chemical binding]; other site 632772004602 Q-loop/lid; other site 632772004603 ABC transporter signature motif; other site 632772004604 Walker B; other site 632772004605 D-loop; other site 632772004606 H-loop/switch region; other site 632772004607 ABC transporter; Region: ABC_tran_2; pfam12848 632772004608 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 632772004609 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 632772004610 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 632772004611 dimer interface [polypeptide binding]; other site 632772004612 ssDNA binding site [nucleotide binding]; other site 632772004613 tetramer (dimer of dimers) interface [polypeptide binding]; other site 632772004614 Copper resistance protein D; Region: CopD; pfam05425 632772004615 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 632772004616 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 632772004617 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 632772004618 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 632772004619 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 632772004620 CoenzymeA binding site [chemical binding]; other site 632772004621 subunit interaction site [polypeptide binding]; other site 632772004622 PHB binding site; other site 632772004623 short chain dehydrogenase; Validated; Region: PRK08264 632772004624 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772004625 NAD(P) binding site [chemical binding]; other site 632772004626 active site 632772004627 Predicted transcriptional regulators [Transcription]; Region: COG1733 632772004628 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 632772004629 glutamate dehydrogenase; Provisional; Region: PRK09414 632772004630 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 632772004631 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 632772004632 NAD(P) binding site [chemical binding]; other site 632772004633 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 632772004634 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 632772004635 putative di-iron ligands [ion binding]; other site 632772004636 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 632772004637 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 632772004638 FAD binding pocket [chemical binding]; other site 632772004639 FAD binding motif [chemical binding]; other site 632772004640 phosphate binding motif [ion binding]; other site 632772004641 beta-alpha-beta structure motif; other site 632772004642 NAD binding pocket [chemical binding]; other site 632772004643 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 632772004644 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 632772004645 catalytic loop [active] 632772004646 iron binding site [ion binding]; other site 632772004647 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 632772004648 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772004649 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 632772004650 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 632772004651 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 632772004652 Ion channel regulatory protein UNC-93; Region: UNC-93; pfam05978 632772004653 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772004654 Predicted transcriptional regulators [Transcription]; Region: COG1695 632772004655 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 632772004656 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 632772004657 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 632772004658 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 632772004659 active site 632772004660 FMN binding site [chemical binding]; other site 632772004661 2,4-decadienoyl-CoA binding site; other site 632772004662 catalytic residue [active] 632772004663 4Fe-4S cluster binding site [ion binding]; other site 632772004664 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 632772004665 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 632772004666 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772004667 NAD(P) binding site [chemical binding]; other site 632772004668 active site 632772004669 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 632772004670 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 632772004671 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 632772004672 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 632772004673 catalytic site [active] 632772004674 putative active site [active] 632772004675 putative substrate binding site [chemical binding]; other site 632772004676 dimer interface [polypeptide binding]; other site 632772004677 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 632772004678 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 632772004679 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 632772004680 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 632772004681 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 632772004682 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 632772004683 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 632772004684 catalytic triad [active] 632772004685 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772004686 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772004687 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 632772004688 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 632772004689 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 632772004690 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 632772004691 phosphate binding site [ion binding]; other site 632772004692 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 632772004693 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 632772004694 active site 2 [active] 632772004695 active site 1 [active] 632772004696 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 632772004697 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 632772004698 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 632772004699 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 632772004700 putative NAD(P) binding site [chemical binding]; other site 632772004701 active site 632772004702 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 632772004703 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 632772004704 active site 632772004705 Glucitol operon activator protein (GutM); Region: GutM; cl01890 632772004706 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 632772004707 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 632772004708 active site 632772004709 dimerization interface [polypeptide binding]; other site 632772004710 ribonuclease PH; Reviewed; Region: rph; PRK00173 632772004711 Ribonuclease PH; Region: RNase_PH_bact; cd11362 632772004712 hexamer interface [polypeptide binding]; other site 632772004713 active site 632772004714 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 632772004715 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 632772004716 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 632772004717 dimer interface [polypeptide binding]; other site 632772004718 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632772004719 catalytic residue [active] 632772004720 Rhomboid family; Region: Rhomboid; pfam01694 632772004721 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 632772004722 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 632772004723 dimer interface [polypeptide binding]; other site 632772004724 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632772004725 catalytic residue [active] 632772004726 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 632772004727 MoaE interaction surface [polypeptide binding]; other site 632772004728 MoeB interaction surface [polypeptide binding]; other site 632772004729 thiocarboxylated glycine; other site 632772004730 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 632772004731 MPN+ (JAMM) motif; other site 632772004732 Zinc-binding site [ion binding]; other site 632772004733 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 632772004734 putative active site pocket [active] 632772004735 cleavage site 632772004736 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 632772004737 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 632772004738 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 632772004739 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 632772004740 active site 632772004741 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 632772004742 Isochorismatase family; Region: Isochorismatase; pfam00857 632772004743 catalytic triad [active] 632772004744 metal binding site [ion binding]; metal-binding site 632772004745 conserved cis-peptide bond; other site 632772004746 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 632772004747 DEAD/DEAH box helicase; Region: DEAD; pfam00270 632772004748 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 632772004749 putative Mg++ binding site [ion binding]; other site 632772004750 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 632772004751 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 632772004752 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 632772004753 Walker A/P-loop; other site 632772004754 ATP binding site [chemical binding]; other site 632772004755 Q-loop/lid; other site 632772004756 ABC transporter signature motif; other site 632772004757 Walker B; other site 632772004758 D-loop; other site 632772004759 H-loop/switch region; other site 632772004760 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 632772004761 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 632772004762 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 632772004763 putative homodimer interface [polypeptide binding]; other site 632772004764 putative active site pocket [active] 632772004765 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 632772004766 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 632772004767 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 632772004768 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 632772004769 active site 632772004770 homodimer interface [polypeptide binding]; other site 632772004771 catalytic site [active] 632772004772 acceptor binding site [chemical binding]; other site 632772004773 glycogen branching enzyme; Provisional; Region: PRK05402 632772004774 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 632772004775 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 632772004776 active site 632772004777 catalytic site [active] 632772004778 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 632772004779 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 632772004780 Transcriptional regulator [Transcription]; Region: IclR; COG1414 632772004781 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 632772004782 Bacterial transcriptional regulator; Region: IclR; pfam01614 632772004783 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 632772004784 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 632772004785 active site 632772004786 intersubunit interface [polypeptide binding]; other site 632772004787 catalytic residue [active] 632772004788 galactonate dehydratase; Provisional; Region: PRK14017 632772004789 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 632772004790 putative active site pocket [active] 632772004791 putative metal binding site [ion binding]; other site 632772004792 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772004793 D-galactonate transporter; Region: 2A0114; TIGR00893 632772004794 putative substrate translocation pore; other site 632772004795 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 632772004796 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 632772004797 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 632772004798 putative acyltransferase; Provisional; Region: PRK05790 632772004799 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 632772004800 dimer interface [polypeptide binding]; other site 632772004801 active site 632772004802 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 632772004803 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 632772004804 dimer interface [polypeptide binding]; other site 632772004805 substrate binding site [chemical binding]; other site 632772004806 metal binding site [ion binding]; metal-binding site 632772004807 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 632772004808 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 632772004809 hypothetical protein; Provisional; Region: PRK03298 632772004810 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 632772004811 dimerization interface [polypeptide binding]; other site 632772004812 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 632772004813 cyclase homology domain; Region: CHD; cd07302 632772004814 nucleotidyl binding site; other site 632772004815 metal binding site [ion binding]; metal-binding site 632772004816 dimer interface [polypeptide binding]; other site 632772004817 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772004818 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772004819 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 632772004820 SNF2 Helicase protein; Region: DUF3670; pfam12419 632772004821 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 632772004822 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 632772004823 ATP binding site [chemical binding]; other site 632772004824 putative Mg++ binding site [ion binding]; other site 632772004825 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 632772004826 nucleotide binding region [chemical binding]; other site 632772004827 ATP-binding site [chemical binding]; other site 632772004828 Uncharacterized conserved protein [Function unknown]; Region: COG4279 632772004829 SWIM zinc finger; Region: SWIM; pfam04434 632772004830 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 632772004831 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 632772004832 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 632772004833 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 632772004834 hinge; other site 632772004835 active site 632772004836 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 632772004837 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 632772004838 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 632772004839 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 632772004840 gamma subunit interface [polypeptide binding]; other site 632772004841 epsilon subunit interface [polypeptide binding]; other site 632772004842 LBP interface [polypeptide binding]; other site 632772004843 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 632772004844 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 632772004845 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 632772004846 alpha subunit interaction interface [polypeptide binding]; other site 632772004847 Walker A motif; other site 632772004848 ATP binding site [chemical binding]; other site 632772004849 Walker B motif; other site 632772004850 inhibitor binding site; inhibition site 632772004851 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 632772004852 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 632772004853 core domain interface [polypeptide binding]; other site 632772004854 delta subunit interface [polypeptide binding]; other site 632772004855 epsilon subunit interface [polypeptide binding]; other site 632772004856 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 632772004857 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 632772004858 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 632772004859 beta subunit interaction interface [polypeptide binding]; other site 632772004860 Walker A motif; other site 632772004861 ATP binding site [chemical binding]; other site 632772004862 Walker B motif; other site 632772004863 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 632772004864 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 632772004865 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 632772004866 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 632772004867 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 632772004868 F0F1 ATP synthase subunit C; Validated; Region: PRK07874 632772004869 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 632772004870 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 632772004871 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 632772004872 Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571 632772004873 Mg++ binding site [ion binding]; other site 632772004874 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 632772004875 putative catalytic motif [active] 632772004876 substrate binding site [chemical binding]; other site 632772004877 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 632772004878 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 632772004879 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772004880 S-adenosylmethionine binding site [chemical binding]; other site 632772004881 peptide chain release factor 1; Validated; Region: prfA; PRK00591 632772004882 This domain is found in peptide chain release factors; Region: PCRF; smart00937 632772004883 RF-1 domain; Region: RF-1; pfam00472 632772004884 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 632772004885 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 632772004886 transcription termination factor Rho; Provisional; Region: PRK12608 632772004887 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 632772004888 RNA binding site [nucleotide binding]; other site 632772004889 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 632772004890 multimer interface [polypeptide binding]; other site 632772004891 Walker A motif; other site 632772004892 ATP binding site [chemical binding]; other site 632772004893 Walker B motif; other site 632772004894 homoserine kinase; Provisional; Region: PRK01212 632772004895 threonine synthase; Reviewed; Region: PRK06721 632772004896 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 632772004897 homodimer interface [polypeptide binding]; other site 632772004898 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632772004899 catalytic residue [active] 632772004900 homoserine dehydrogenase; Provisional; Region: PRK06349 632772004901 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 632772004902 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 632772004903 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 632772004904 diaminopimelate decarboxylase; Region: lysA; TIGR01048 632772004905 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 632772004906 active site 632772004907 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 632772004908 substrate binding site [chemical binding]; other site 632772004909 catalytic residues [active] 632772004910 dimer interface [polypeptide binding]; other site 632772004911 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 632772004912 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 632772004913 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 632772004914 active site 632772004915 HIGH motif; other site 632772004916 KMSK motif region; other site 632772004917 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 632772004918 tRNA binding surface [nucleotide binding]; other site 632772004919 anticodon binding site; other site 632772004920 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 632772004921 Domain of unknown function (DUF305); Region: DUF305; pfam03713 632772004922 putative phosphoketolase; Provisional; Region: PRK05261 632772004923 XFP N-terminal domain; Region: XFP_N; pfam09364 632772004924 XFP C-terminal domain; Region: XFP_C; pfam09363 632772004925 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 632772004926 RhlG and related beta-ketoacyl reductases, classical (c) SDRs; Region: RhlG_SDR_c; cd08942 632772004927 NADP binding site [chemical binding]; other site 632772004928 active site 632772004929 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 632772004930 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 632772004931 NAD(P) binding site [chemical binding]; other site 632772004932 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772004933 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 632772004934 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772004935 active site 632772004936 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772004937 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772004938 active site 632772004939 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 632772004940 putative active site [active] 632772004941 putative substrate binding site [chemical binding]; other site 632772004942 ATP binding site [chemical binding]; other site 632772004943 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 632772004944 classical (c) SDRs; Region: SDR_c; cd05233 632772004945 NAD(P) binding site [chemical binding]; other site 632772004946 active site 632772004947 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772004948 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772004949 active site 632772004950 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 632772004951 classical (c) SDRs; Region: SDR_c; cd05233 632772004952 NAD(P) binding site [chemical binding]; other site 632772004953 active site 632772004954 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 632772004955 putative active site [active] 632772004956 putative catalytic site [active] 632772004957 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 632772004958 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 632772004959 acyl-activating enzyme (AAE) consensus motif; other site 632772004960 putative AMP binding site [chemical binding]; other site 632772004961 putative active site [active] 632772004962 putative CoA binding site [chemical binding]; other site 632772004963 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 632772004964 Prostaglandin dehydrogenases; Region: PGDH; cd05288 632772004965 NAD(P) binding site [chemical binding]; other site 632772004966 substrate binding site [chemical binding]; other site 632772004967 dimer interface [polypeptide binding]; other site 632772004968 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772004969 Hemerythrin-like domain; Region: Hr-like; cd12108 632772004970 Fe binding site [ion binding]; other site 632772004971 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 632772004972 hydrophobic ligand binding site; other site 632772004973 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772004974 metabolite-proton symporter; Region: 2A0106; TIGR00883 632772004975 putative substrate translocation pore; other site 632772004976 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772004977 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772004978 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772004979 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772004980 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: Php; COG1735 632772004981 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 632772004982 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 632772004983 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 632772004984 active site 632772004985 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 632772004986 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 632772004987 CysD dimerization site [polypeptide binding]; other site 632772004988 G1 box; other site 632772004989 putative GEF interaction site [polypeptide binding]; other site 632772004990 GTP/Mg2+ binding site [chemical binding]; other site 632772004991 Switch I region; other site 632772004992 G2 box; other site 632772004993 G3 box; other site 632772004994 Switch II region; other site 632772004995 G4 box; other site 632772004996 G5 box; other site 632772004997 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 632772004998 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 632772004999 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 632772005000 ligand-binding site [chemical binding]; other site 632772005001 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 632772005002 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 632772005003 Active Sites [active] 632772005004 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 632772005005 short chain dehydrogenase; Provisional; Region: PRK07890 632772005006 classical (c) SDRs; Region: SDR_c; cd05233 632772005007 NAD(P) binding site [chemical binding]; other site 632772005008 active site 632772005009 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 632772005010 Low molecular weight phosphatase family; Region: LMWPc; cl00105 632772005011 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 632772005012 active site 632772005013 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 632772005014 Clp protease; Region: CLP_protease; pfam00574 632772005015 oligomer interface [polypeptide binding]; other site 632772005016 active site residues [active] 632772005017 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 632772005018 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 632772005019 oligomer interface [polypeptide binding]; other site 632772005020 active site residues [active] 632772005021 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 632772005022 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 632772005023 non-specific DNA binding site [nucleotide binding]; other site 632772005024 salt bridge; other site 632772005025 sequence-specific DNA binding site [nucleotide binding]; other site 632772005026 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 632772005027 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 632772005028 dimer interface [polypeptide binding]; other site 632772005029 active site 632772005030 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772005031 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772005032 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 632772005033 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 632772005034 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 632772005035 active site 632772005036 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 632772005037 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772005038 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772005039 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 632772005040 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772005041 putative substrate translocation pore; other site 632772005042 Transcriptional regulators [Transcription]; Region: MarR; COG1846 632772005043 MarR family; Region: MarR; pfam01047 632772005044 enoyl-CoA hydratase; Provisional; Region: PRK05862 632772005045 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772005046 substrate binding site [chemical binding]; other site 632772005047 oxyanion hole (OAH) forming residues; other site 632772005048 trimer interface [polypeptide binding]; other site 632772005049 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 632772005050 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 632772005051 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 632772005052 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772005053 substrate binding site [chemical binding]; other site 632772005054 oxyanion hole (OAH) forming residues; other site 632772005055 trimer interface [polypeptide binding]; other site 632772005056 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 632772005057 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772005058 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 632772005059 substrate binding pocket [chemical binding]; other site 632772005060 FAD binding site [chemical binding]; other site 632772005061 catalytic base [active] 632772005062 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 632772005063 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 632772005064 tetrameric interface [polypeptide binding]; other site 632772005065 NAD binding site [chemical binding]; other site 632772005066 catalytic residues [active] 632772005067 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 632772005068 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 632772005069 active site 632772005070 CutC family; Region: CutC; cl01218 632772005071 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 632772005072 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 632772005073 active site 632772005074 trimer interface [polypeptide binding]; other site 632772005075 allosteric site; other site 632772005076 active site lid [active] 632772005077 hexamer (dimer of trimers) interface [polypeptide binding]; other site 632772005078 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 632772005079 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 632772005080 active site 632772005081 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 632772005082 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 632772005083 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 632772005084 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 632772005085 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 632772005086 dimerization domain swap beta strand [polypeptide binding]; other site 632772005087 regulatory protein interface [polypeptide binding]; other site 632772005088 active site 632772005089 regulatory phosphorylation site [posttranslational modification]; other site 632772005090 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 632772005091 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 632772005092 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 632772005093 active site turn [active] 632772005094 phosphorylation site [posttranslational modification] 632772005095 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 632772005096 HPr interaction site; other site 632772005097 glycerol kinase (GK) interaction site [polypeptide binding]; other site 632772005098 active site 632772005099 phosphorylation site [posttranslational modification] 632772005100 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 632772005101 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772005102 DNA-binding site [nucleotide binding]; DNA binding site 632772005103 UTRA domain; Region: UTRA; pfam07702 632772005104 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 632772005105 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 632772005106 FAD binding domain; Region: FAD_binding_4; pfam01565 632772005107 Berberine and berberine like; Region: BBE; pfam08031 632772005108 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 632772005109 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 632772005110 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 632772005111 AAA ATPase domain; Region: AAA_16; pfam13191 632772005112 Uncharacterized conserved protein [Function unknown]; Region: COG4279 632772005113 SWIM zinc finger; Region: SWIM; pfam04434 632772005114 SNF2 Helicase protein; Region: DUF3670; pfam12419 632772005115 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 632772005116 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 632772005117 putative Mg++ binding site [ion binding]; other site 632772005118 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 632772005119 nucleotide binding region [chemical binding]; other site 632772005120 ATP-binding site [chemical binding]; other site 632772005121 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 632772005122 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 632772005123 putative NAD(P) binding site [chemical binding]; other site 632772005124 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 632772005125 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 632772005126 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 632772005127 Moco binding site; other site 632772005128 metal coordination site [ion binding]; other site 632772005129 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 632772005130 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 632772005131 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 632772005132 shikimate binding site; other site 632772005133 NAD(P) binding site [chemical binding]; other site 632772005134 putative OHCU decarboxylase; Provisional; Region: PRK13798 632772005135 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 632772005136 active site 632772005137 homotetramer interface [polypeptide binding]; other site 632772005138 urate oxidase; Region: urate_oxi; TIGR03383 632772005139 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 632772005140 active site 632772005141 xanthine permease; Region: pbuX; TIGR03173 632772005142 Transcriptional regulator [Transcription]; Region: LysR; COG0583 632772005143 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 632772005144 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 632772005145 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 632772005146 putative ADP-ribose binding site [chemical binding]; other site 632772005147 putative active site [active] 632772005148 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 632772005149 benzoate transporter; Region: benE; TIGR00843 632772005150 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 632772005151 active site 632772005152 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 632772005153 Phosphotransferase enzyme family; Region: APH; pfam01636 632772005154 putative active site [active] 632772005155 putative substrate binding site [chemical binding]; other site 632772005156 ATP binding site [chemical binding]; other site 632772005157 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 632772005158 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 632772005159 TPP-binding site [chemical binding]; other site 632772005160 heterodimer interface [polypeptide binding]; other site 632772005161 tetramer interface [polypeptide binding]; other site 632772005162 phosphorylation loop region [posttranslational modification] 632772005163 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 632772005164 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 632772005165 alpha subunit interface [polypeptide binding]; other site 632772005166 TPP binding site [chemical binding]; other site 632772005167 heterodimer interface [polypeptide binding]; other site 632772005168 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 632772005169 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 632772005170 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 632772005171 E3 interaction surface; other site 632772005172 lipoyl attachment site [posttranslational modification]; other site 632772005173 e3 binding domain; Region: E3_binding; pfam02817 632772005174 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 632772005175 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772005176 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 632772005177 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 632772005178 Multicopper oxidase; Region: Cu-oxidase; pfam00394 632772005179 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 632772005180 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 632772005181 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 632772005182 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 632772005183 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 632772005184 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 632772005185 ligand binding site [chemical binding]; other site 632772005186 homodimer interface [polypeptide binding]; other site 632772005187 NAD(P) binding site [chemical binding]; other site 632772005188 trimer interface B [polypeptide binding]; other site 632772005189 trimer interface A [polypeptide binding]; other site 632772005190 Protein of unknown function, DUF488; Region: DUF488; cl01246 632772005191 Oxygen-sensitive ribonucleoside-triphosphate reductase [Nucleotide transport and metabolism]; Region: NrdD; COG1328 632772005192 acyl-CoA synthetase; Provisional; Region: PRK13391 632772005193 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772005194 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 632772005195 acyl-activating enzyme (AAE) consensus motif; other site 632772005196 putative AMP binding site [chemical binding]; other site 632772005197 putative active site [active] 632772005198 acyl-activating enzyme (AAE) consensus motif; other site 632772005199 putative CoA binding site [chemical binding]; other site 632772005200 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 632772005201 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 632772005202 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 632772005203 conserved cys residue [active] 632772005204 FAD binding domain; Region: FAD_binding_4; pfam01565 632772005205 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 632772005206 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 632772005207 Predicted acetyltransferase [General function prediction only]; Region: COG2388 632772005208 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 632772005209 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 632772005210 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772005211 H+ Antiporter protein; Region: 2A0121; TIGR00900 632772005212 putative substrate translocation pore; other site 632772005213 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 632772005214 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 632772005215 substrate binding pocket [chemical binding]; other site 632772005216 catalytic triad [active] 632772005217 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 632772005218 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 632772005219 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 632772005220 NMT1/THI5 like; Region: NMT1; pfam09084 632772005221 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 632772005222 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772005223 dimer interface [polypeptide binding]; other site 632772005224 conserved gate region; other site 632772005225 putative PBP binding loops; other site 632772005226 ABC-ATPase subunit interface; other site 632772005227 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 632772005228 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 632772005229 Walker A/P-loop; other site 632772005230 ATP binding site [chemical binding]; other site 632772005231 Q-loop/lid; other site 632772005232 ABC transporter signature motif; other site 632772005233 Walker B; other site 632772005234 D-loop; other site 632772005235 H-loop/switch region; other site 632772005236 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 632772005237 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 632772005238 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 632772005239 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 632772005240 L-aspartate oxidase; Provisional; Region: PRK07804 632772005241 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 632772005242 potential frameshift: common BLAST hit: gi|111018603|ref|YP_701575.1| L-aspartate oxidase 632772005243 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 632772005244 EspG family; Region: ESX-1_EspG; pfam14011 632772005245 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 632772005246 Trp docking motif [polypeptide binding]; other site 632772005247 active site 632772005248 PQQ-like domain; Region: PQQ_2; pfam13360 632772005249 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 632772005250 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772005251 S-adenosylmethionine binding site [chemical binding]; other site 632772005252 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 632772005253 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 632772005254 NAD(P) binding site [chemical binding]; other site 632772005255 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 632772005256 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772005257 acyl-activating enzyme (AAE) consensus motif; other site 632772005258 AMP binding site [chemical binding]; other site 632772005259 active site 632772005260 CoA binding site [chemical binding]; other site 632772005261 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772005262 metabolite-proton symporter; Region: 2A0106; TIGR00883 632772005263 putative substrate translocation pore; other site 632772005264 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 632772005265 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772005266 NAD(P) binding site [chemical binding]; other site 632772005267 active site 632772005268 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772005269 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772005270 active site 632772005271 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772005272 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772005273 SnoaL-like domain; Region: SnoaL_2; pfam12680 632772005274 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 632772005275 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 632772005276 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 632772005277 NAD(P) binding pocket [chemical binding]; other site 632772005278 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 632772005279 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 632772005280 dimer interface [polypeptide binding]; other site 632772005281 PYR/PP interface [polypeptide binding]; other site 632772005282 TPP binding site [chemical binding]; other site 632772005283 substrate binding site [chemical binding]; other site 632772005284 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 632772005285 TPP-binding site [chemical binding]; other site 632772005286 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 632772005287 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 632772005288 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632772005289 putative DNA binding site [nucleotide binding]; other site 632772005290 putative Zn2+ binding site [ion binding]; other site 632772005291 AsnC family; Region: AsnC_trans_reg; pfam01037 632772005292 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-II; Region: Lumazine_synthase-II; cd09208 632772005293 active site 632772005294 homopentamer interface [polypeptide binding]; other site 632772005295 dimer interface [polypeptide binding]; other site 632772005296 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 632772005297 pentamer interface [polypeptide binding]; other site 632772005298 dodecaamer interface [polypeptide binding]; other site 632772005299 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 632772005300 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 632772005301 putative NAD(P) binding site [chemical binding]; other site 632772005302 catalytic Zn binding site [ion binding]; other site 632772005303 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 632772005304 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 632772005305 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 632772005306 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 632772005307 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 632772005308 SnoaL-like domain; Region: SnoaL_3; pfam13474 632772005309 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 632772005310 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 632772005311 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 632772005312 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 632772005313 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 632772005314 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 632772005315 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 632772005316 FAD binding domain; Region: FAD_binding_4; pfam01565 632772005317 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 632772005318 Domain of unknown function (DUF427); Region: DUF427; pfam04248 632772005319 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 632772005320 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 632772005321 active site 632772005322 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 632772005323 non-prolyl cis peptide bond; other site 632772005324 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 632772005325 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 632772005326 active site 632772005327 DNA binding site [nucleotide binding] 632772005328 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 632772005329 DNA binding site [nucleotide binding] 632772005330 short chain dehydrogenase; Provisional; Region: PRK06123 632772005331 classical (c) SDRs; Region: SDR_c; cd05233 632772005332 NAD(P) binding site [chemical binding]; other site 632772005333 active site 632772005334 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 632772005335 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 632772005336 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 632772005337 ATP binding site [chemical binding]; other site 632772005338 putative Mg++ binding site [ion binding]; other site 632772005339 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 632772005340 nucleotide binding region [chemical binding]; other site 632772005341 ATP-binding site [chemical binding]; other site 632772005342 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 632772005343 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 632772005344 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 632772005345 Helix-turn-helix domain; Region: HTH_17; pfam12728 632772005346 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 632772005347 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 632772005348 active site 632772005349 metal binding site [ion binding]; metal-binding site 632772005350 hexamer interface [polypeptide binding]; other site 632772005351 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 632772005352 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 632772005353 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 632772005354 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 632772005355 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 632772005356 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 632772005357 Calcium binding; Region: Calci_bind_CcbP; pfam11535 632772005358 Ribosomal protein S19e; Region: Ribosomal_S19e; cl00969 632772005359 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 632772005360 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 632772005361 DNA binding site [nucleotide binding] 632772005362 Transcriptional regulators [Transcription]; Region: PurR; COG1609 632772005363 domain linker motif; other site 632772005364 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 632772005365 dimerization interface [polypeptide binding]; other site 632772005366 ligand binding site [chemical binding]; other site 632772005367 D-galactonate transporter; Region: 2A0114; TIGR00893 632772005368 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772005369 putative substrate translocation pore; other site 632772005370 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 632772005371 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 632772005372 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 632772005373 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 632772005374 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772005375 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772005376 active site 632772005377 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 632772005378 classical (c) SDRs; Region: SDR_c; cd05233 632772005379 NAD(P) binding site [chemical binding]; other site 632772005380 active site 632772005381 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 632772005382 DNA-binding interface [nucleotide binding]; DNA binding site 632772005383 Predicted ATPase [General function prediction only]; Region: COG3903 632772005384 Tetratricopeptide repeat; Region: TPR_12; pfam13424 632772005385 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632772005386 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632772005387 DNA binding residues [nucleotide binding] 632772005388 dimerization interface [polypeptide binding]; other site 632772005389 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 632772005390 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 632772005391 dimerization interface [polypeptide binding]; other site 632772005392 active site 632772005393 HRDC domain; Region: HRDC; cl02578 632772005394 Tubulin like; Region: Tubulin_2; pfam13809 632772005395 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 632772005396 metal ion-dependent adhesion site (MIDAS); other site 632772005397 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 632772005398 Nuclease-related domain; Region: NERD; pfam08378 632772005399 Part of AAA domain; Region: AAA_19; pfam13245 632772005400 Family description; Region: UvrD_C_2; pfam13538 632772005401 CoA binding domain; Region: CoA_binding_2; pfam13380 632772005402 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 632772005403 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 632772005404 putative metal binding site [ion binding]; other site 632772005405 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772005406 S-adenosylmethionine binding site [chemical binding]; other site 632772005407 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 632772005408 active site residue [active] 632772005409 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 632772005410 MarR family; Region: MarR_2; pfam12802 632772005411 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 632772005412 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 632772005413 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772005414 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 632772005415 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 632772005416 DNA polymerase IV; Validated; Region: PRK03352 632772005417 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 632772005418 active site 632772005419 DNA binding site [nucleotide binding] 632772005420 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 632772005421 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 632772005422 Catalytic domain of Protein Kinases; Region: PKc; cd00180 632772005423 active site 632772005424 ATP binding site [chemical binding]; other site 632772005425 substrate binding site [chemical binding]; other site 632772005426 activation loop (A-loop); other site 632772005427 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 632772005428 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 632772005429 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 632772005430 Predicted acetyltransferase [General function prediction only]; Region: COG2388 632772005431 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 632772005432 Thioredoxin; Region: Thioredoxin_4; pfam13462 632772005433 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 632772005434 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 632772005435 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 632772005436 putative hydrophobic ligand binding site [chemical binding]; other site 632772005437 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 632772005438 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 632772005439 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 632772005440 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 632772005441 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 632772005442 active site 2 [active] 632772005443 active site 1 [active] 632772005444 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 632772005445 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 632772005446 putative di-iron ligands [ion binding]; other site 632772005447 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 632772005448 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 632772005449 Protein of unknown function (DUF2848); Region: DUF2848; pfam11010 632772005450 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772005451 metabolite-proton symporter; Region: 2A0106; TIGR00883 632772005452 putative substrate translocation pore; other site 632772005453 Transcriptional regulators [Transcription]; Region: GntR; COG1802 632772005454 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772005455 DNA-binding site [nucleotide binding]; DNA binding site 632772005456 FCD domain; Region: FCD; pfam07729 632772005457 Predicted amidohydrolase [General function prediction only]; Region: COG0388 632772005458 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 632772005459 putative active site [active] 632772005460 catalytic triad [active] 632772005461 putative dimer interface [polypeptide binding]; other site 632772005462 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 632772005463 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 632772005464 NAD(P) binding site [chemical binding]; other site 632772005465 catalytic residues [active] 632772005466 choline dehydrogenase; Validated; Region: PRK02106 632772005467 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 632772005468 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 632772005469 NlpC/P60 family; Region: NLPC_P60; pfam00877 632772005470 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 632772005471 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 632772005472 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 632772005473 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 632772005474 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 632772005475 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 632772005476 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 632772005477 Walker A/P-loop; other site 632772005478 ATP binding site [chemical binding]; other site 632772005479 Q-loop/lid; other site 632772005480 ABC transporter signature motif; other site 632772005481 Walker B; other site 632772005482 D-loop; other site 632772005483 H-loop/switch region; other site 632772005484 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 632772005485 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 632772005486 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 632772005487 Walker A/P-loop; other site 632772005488 ATP binding site [chemical binding]; other site 632772005489 Q-loop/lid; other site 632772005490 ABC transporter signature motif; other site 632772005491 Walker B; other site 632772005492 D-loop; other site 632772005493 H-loop/switch region; other site 632772005494 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 632772005495 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 632772005496 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772005497 dimer interface [polypeptide binding]; other site 632772005498 conserved gate region; other site 632772005499 putative PBP binding loops; other site 632772005500 ABC-ATPase subunit interface; other site 632772005501 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 632772005502 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772005503 dimer interface [polypeptide binding]; other site 632772005504 conserved gate region; other site 632772005505 putative PBP binding loops; other site 632772005506 ABC-ATPase subunit interface; other site 632772005507 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_9; cd08496 632772005508 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 632772005509 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 632772005510 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 632772005511 active site 632772005512 non-prolyl cis peptide bond; other site 632772005513 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 632772005514 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772005515 DNA-binding site [nucleotide binding]; DNA binding site 632772005516 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 632772005517 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 632772005518 catalytic residue [active] 632772005519 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 632772005520 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 632772005521 TAP-like protein; Region: Abhydrolase_4; pfam08386 632772005522 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 632772005523 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 632772005524 homodimer interface [polypeptide binding]; other site 632772005525 substrate-cofactor binding pocket; other site 632772005526 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632772005527 catalytic residue [active] 632772005528 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 632772005529 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 632772005530 active site 632772005531 dimer interface [polypeptide binding]; other site 632772005532 non-prolyl cis peptide bond; other site 632772005533 insertion regions; other site 632772005534 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 632772005535 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 632772005536 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 632772005537 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772005538 NAD(P) binding site [chemical binding]; other site 632772005539 active site 632772005540 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 632772005541 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 632772005542 tellurite resistance protein terB; Region: terB; cd07176 632772005543 putative metal binding site [ion binding]; other site 632772005544 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 632772005545 A new structural DNA glycosylase; Region: AlkD_like; cd06561 632772005546 active site 632772005547 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 632772005548 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 632772005549 Na binding site [ion binding]; other site 632772005550 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 632772005551 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 632772005552 active site 632772005553 metal binding site [ion binding]; metal-binding site 632772005554 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 632772005555 Aspartase; Region: Aspartase; cd01357 632772005556 active sites [active] 632772005557 tetramer interface [polypeptide binding]; other site 632772005558 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 632772005559 amidohydrolase; Region: amidohydrolases; TIGR01891 632772005560 metal binding site [ion binding]; metal-binding site 632772005561 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 632772005562 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 632772005563 homotrimer interaction site [polypeptide binding]; other site 632772005564 putative active site [active] 632772005565 4-hydroxyphenylacetate 3-hydroxylase N terminal; Region: HpaB_N; pfam11794 632772005566 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 632772005567 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 632772005568 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 632772005569 hypothetical protein; Provisional; Region: PRK01346 632772005570 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 632772005571 Transcriptional regulator [Transcription]; Region: LysR; COG0583 632772005572 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 632772005573 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 632772005574 putative substrate binding pocket [chemical binding]; other site 632772005575 dimerization interface [polypeptide binding]; other site 632772005576 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 632772005577 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772005578 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772005579 Trimethylamine dehydrogenase (TMADH) and histamine dehydrogenase (HD) FMN-binding domain. TMADH is an iron-sulfur flavoprotein that catalyzes the oxidative demethylation of trimethylamine to form dimethylamine and formaldehyde. The protein forms a...; Region: TMADH_HD_FMN; cd02929 632772005580 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 632772005581 FMN binding site [chemical binding]; other site 632772005582 active site 632772005583 homodimer interface [polypeptide binding]; other site 632772005584 putative catalytic residue [active] 632772005585 4Fe-4S cluster binding site [ion binding]; other site 632772005586 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 632772005587 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 632772005588 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 632772005589 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 632772005590 NAD(P) binding site [chemical binding]; other site 632772005591 catalytic residues [active] 632772005592 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 632772005593 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 632772005594 Coenzyme A binding pocket [chemical binding]; other site 632772005595 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 632772005596 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 632772005597 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 632772005598 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 632772005599 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 632772005600 Domain of unknown function (DUF385); Region: DUF385; pfam04075 632772005601 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 632772005602 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 632772005603 active site 632772005604 dimer interface [polypeptide binding]; other site 632772005605 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 632772005606 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 632772005607 active site 632772005608 FMN binding site [chemical binding]; other site 632772005609 substrate binding site [chemical binding]; other site 632772005610 3Fe-4S cluster binding site [ion binding]; other site 632772005611 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 632772005612 domain_subunit interface; other site 632772005613 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 632772005614 Flavodoxin; Region: Flavodoxin_1; pfam00258 632772005615 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 632772005616 FAD binding pocket [chemical binding]; other site 632772005617 FAD binding motif [chemical binding]; other site 632772005618 catalytic residues [active] 632772005619 NAD binding pocket [chemical binding]; other site 632772005620 phosphate binding motif [ion binding]; other site 632772005621 beta-alpha-beta structure motif; other site 632772005622 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 632772005623 PaaX-like protein; Region: PaaX; pfam07848 632772005624 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 632772005625 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 632772005626 kynureninase; Region: kynureninase; TIGR01814 632772005627 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 632772005628 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 632772005629 catalytic residue [active] 632772005630 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 632772005631 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 632772005632 NADP binding site [chemical binding]; other site 632772005633 active site 632772005634 regulatory binding site [polypeptide binding]; other site 632772005635 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 632772005636 RibD C-terminal domain; Region: RibD_C; cl17279 632772005637 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 632772005638 potential frameshift: common BLAST hit: gi|111017640|ref|YP_700612.1| alkanesulfonate monooxygenase 632772005639 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 632772005640 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 632772005641 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 632772005642 choline dehydrogenase; Validated; Region: PRK02106 632772005643 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 632772005644 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 632772005645 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 632772005646 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 632772005647 tetramerization interface [polypeptide binding]; other site 632772005648 NAD(P) binding site [chemical binding]; other site 632772005649 catalytic residues [active] 632772005650 BCCT family transporter; Region: BCCT; pfam02028 632772005651 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 632772005652 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 632772005653 [2Fe-2S] cluster binding site [ion binding]; other site 632772005654 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 632772005655 putative alpha subunit interface [polypeptide binding]; other site 632772005656 putative active site [active] 632772005657 putative substrate binding site [chemical binding]; other site 632772005658 Fe binding site [ion binding]; other site 632772005659 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 632772005660 Transcriptional regulator [Transcription]; Region: IclR; COG1414 632772005661 Bacterial transcriptional regulator; Region: IclR; pfam01614 632772005662 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 632772005663 [2Fe-2S] cluster binding site [ion binding]; other site 632772005664 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 632772005665 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 632772005666 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 632772005667 Transcriptional regulator [Transcription]; Region: IclR; COG1414 632772005668 Bacterial transcriptional regulator; Region: IclR; pfam01614 632772005669 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 632772005670 hydroxyglutarate oxidase; Provisional; Region: PRK11728 632772005671 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 632772005672 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 632772005673 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 632772005674 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 632772005675 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 632772005676 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 632772005677 homodimer interface [polypeptide binding]; other site 632772005678 NADP binding site [chemical binding]; other site 632772005679 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 632772005680 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 632772005681 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 632772005682 putative active site [active] 632772005683 putative substrate binding site [chemical binding]; other site 632772005684 putative cosubstrate binding site; other site 632772005685 catalytic site [active] 632772005686 Transcriptional regulators [Transcription]; Region: GntR; COG1802 632772005687 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 632772005688 DNA-binding site [nucleotide binding]; DNA binding site 632772005689 FCD domain; Region: FCD; pfam07729 632772005690 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 632772005691 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 632772005692 dimer interface [polypeptide binding]; other site 632772005693 active site 632772005694 glycine-pyridoxal phosphate binding site [chemical binding]; other site 632772005695 folate binding site [chemical binding]; other site 632772005696 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 632772005697 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 632772005698 hydroxyglutarate oxidase; Provisional; Region: PRK11728 632772005699 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 632772005700 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 632772005701 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 632772005702 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 632772005703 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 632772005704 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 632772005705 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 632772005706 dihydropteroate synthase; Region: DHPS; TIGR01496 632772005707 substrate binding pocket [chemical binding]; other site 632772005708 dimer interface [polypeptide binding]; other site 632772005709 inhibitor binding site; inhibition site 632772005710 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 632772005711 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 632772005712 substrate-cofactor binding pocket; other site 632772005713 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632772005714 catalytic residue [active] 632772005715 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 632772005716 lipoyl attachment site [posttranslational modification]; other site 632772005717 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 632772005718 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 632772005719 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 632772005720 Catalytic domain of Protein Kinases; Region: PKc; cd00180 632772005721 active site 632772005722 ATP binding site [chemical binding]; other site 632772005723 substrate binding site [chemical binding]; other site 632772005724 activation loop (A-loop); other site 632772005725 AAA domain; Region: AAA_22; pfam13401 632772005726 AAA ATPase domain; Region: AAA_16; pfam13191 632772005727 Tetratricopeptide repeat; Region: TPR_12; pfam13424 632772005728 Transcriptional regulator [Transcription]; Region: IclR; COG1414 632772005729 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 632772005730 Bacterial transcriptional regulator; Region: IclR; pfam01614 632772005731 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 632772005732 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 632772005733 Creatine amidinohydrolase. E.C.3.5.3.3. Hydrolyzes creatine to sarcosine and urea; Region: Creatinase; cd01090 632772005734 active site 632772005735 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772005736 metabolite-proton symporter; Region: 2A0106; TIGR00883 632772005737 putative substrate translocation pore; other site 632772005738 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 632772005739 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 632772005740 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 632772005741 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 632772005742 Na binding site [ion binding]; other site 632772005743 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 632772005744 tetramer interface [polypeptide binding]; other site 632772005745 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 632772005746 active site 632772005747 Excalibur calcium-binding domain; Region: Excalibur; smart00894 632772005748 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 632772005749 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 632772005750 Domain of unknown function (DUF4188); Region: DUF4188; pfam13826 632772005751 Predicted membrane protein [Function unknown]; Region: COG4270 632772005752 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 632772005753 AAA domain; Region: AAA_30; pfam13604 632772005754 Family description; Region: UvrD_C_2; pfam13538 632772005755 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 632772005756 Part of AAA domain; Region: AAA_19; pfam13245 632772005757 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 632772005758 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 632772005759 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 632772005760 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 632772005761 GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; Region: GIY-YIG_COG3680; cd10440 632772005762 GIY-YIG motif/motif A; other site 632772005763 putative active site [active] 632772005764 putative metal binding site [ion binding]; other site 632772005765 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 632772005766 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 632772005767 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 632772005768 dihydroxyacetone kinase; Provisional; Region: PRK14479 632772005769 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 632772005770 DAK2 domain; Region: Dak2; pfam02734 632772005771 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 632772005772 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 632772005773 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 632772005774 metabolite-proton symporter; Region: 2A0106; TIGR00883 632772005775 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772005776 putative substrate translocation pore; other site 632772005777 Transcriptional regulator [Transcription]; Region: LysR; COG0583 632772005778 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 632772005779 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 632772005780 putative substrate binding pocket [chemical binding]; other site 632772005781 dimerization interface [polypeptide binding]; other site 632772005782 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 632772005783 hypothetical protein; Provisional; Region: PRK12839 632772005784 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 632772005785 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 632772005786 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 632772005787 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 632772005788 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 632772005789 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 632772005790 active site 632772005791 catalytic tetrad [active] 632772005792 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 632772005793 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 632772005794 active site 632772005795 FMN binding site [chemical binding]; other site 632772005796 substrate binding site [chemical binding]; other site 632772005797 putative catalytic residue [active] 632772005798 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 632772005799 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 632772005800 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 632772005801 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 632772005802 shikimate binding site; other site 632772005803 NAD(P) binding site [chemical binding]; other site 632772005804 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772005805 metabolite-proton symporter; Region: 2A0106; TIGR00883 632772005806 putative substrate translocation pore; other site 632772005807 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 632772005808 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 632772005809 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 632772005810 dimerization interface [polypeptide binding]; other site 632772005811 substrate binding pocket [chemical binding]; other site 632772005812 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 632772005813 classical (c) SDRs; Region: SDR_c; cd05233 632772005814 NAD(P) binding site [chemical binding]; other site 632772005815 active site 632772005816 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 632772005817 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 632772005818 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 632772005819 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 632772005820 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 632772005821 Cupin domain; Region: Cupin_2; pfam07883 632772005822 Cupin domain; Region: Cupin_2; cl17218 632772005823 Transcriptional regulator [Transcription]; Region: IclR; COG1414 632772005824 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 632772005825 Bacterial transcriptional regulator; Region: IclR; pfam01614 632772005826 benzoate transport; Region: 2A0115; TIGR00895 632772005827 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772005828 putative substrate translocation pore; other site 632772005829 salicylate hydroxylase; Provisional; Region: PRK08163 632772005830 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 632772005831 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 632772005832 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 632772005833 oligomer interface [polypeptide binding]; other site 632772005834 metal binding site [ion binding]; metal-binding site 632772005835 metal binding site [ion binding]; metal-binding site 632772005836 putative Cl binding site [ion binding]; other site 632772005837 aspartate ring; other site 632772005838 basic sphincter; other site 632772005839 hydrophobic gate; other site 632772005840 periplasmic entrance; other site 632772005841 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 632772005842 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 632772005843 active site 632772005844 FMN binding site [chemical binding]; other site 632772005845 substrate binding site [chemical binding]; other site 632772005846 3Fe-4S cluster binding site [ion binding]; other site 632772005847 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772005848 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772005849 Patatin-like phospholipase; Region: Patatin; pfam01734 632772005850 active site 632772005851 nucleophile elbow; other site 632772005852 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 632772005853 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 632772005854 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772005855 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772005856 active site 632772005857 putative acyltransferase; Provisional; Region: PRK05790 632772005858 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 632772005859 dimer interface [polypeptide binding]; other site 632772005860 active site 632772005861 choline dehydrogenase; Validated; Region: PRK02106 632772005862 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 632772005863 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 632772005864 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 632772005865 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 632772005866 tetramerization interface [polypeptide binding]; other site 632772005867 NAD(P) binding site [chemical binding]; other site 632772005868 catalytic residues [active] 632772005869 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 632772005870 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 632772005871 active site 632772005872 catalytic tetrad [active] 632772005873 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 632772005874 Protein of unknown function (DUF2430); Region: DUF2430; pfam10353 632772005875 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 632772005876 3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341 632772005877 homotetramer interface [polypeptide binding]; other site 632772005878 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 632772005879 NAD binding site [chemical binding]; other site 632772005880 homodimer interface [polypeptide binding]; other site 632772005881 active site 632772005882 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 632772005883 classical (c) SDRs; Region: SDR_c; cd05233 632772005884 NAD(P) binding site [chemical binding]; other site 632772005885 active site 632772005886 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 632772005887 classical (c) SDRs; Region: SDR_c; cd05233 632772005888 NAD(P) binding site [chemical binding]; other site 632772005889 active site 632772005890 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 632772005891 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 632772005892 Domain of unknown function (DUF222); Region: DUF222; pfam02720 632772005893 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 632772005894 active site 632772005895 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 632772005896 HipA N-terminal domain; Region: Couple_hipA; pfam13657 632772005897 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 632772005898 HipA-like N-terminal domain; Region: HipA_N; pfam07805 632772005899 HipA-like C-terminal domain; Region: HipA_C; pfam07804 632772005900 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 632772005901 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 632772005902 salt bridge; other site 632772005903 non-specific DNA binding site [nucleotide binding]; other site 632772005904 sequence-specific DNA binding site [nucleotide binding]; other site 632772005905 endonuclease IV; Provisional; Region: PRK01060 632772005906 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 632772005907 AP (apurinic/apyrimidinic) site pocket; other site 632772005908 DNA interaction; other site 632772005909 Metal-binding active site; metal-binding site 632772005910 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 632772005911 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 632772005912 Sulfate transporter family; Region: Sulfate_transp; pfam00916 632772005913 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 632772005914 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 632772005915 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 632772005916 substrate binding pocket [chemical binding]; other site 632772005917 membrane-bound complex binding site; other site 632772005918 hinge residues; other site 632772005919 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 632772005920 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772005921 dimer interface [polypeptide binding]; other site 632772005922 conserved gate region; other site 632772005923 putative PBP binding loops; other site 632772005924 ABC-ATPase subunit interface; other site 632772005925 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 632772005926 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 632772005927 Walker A/P-loop; other site 632772005928 ATP binding site [chemical binding]; other site 632772005929 Q-loop/lid; other site 632772005930 ABC transporter signature motif; other site 632772005931 Walker B; other site 632772005932 D-loop; other site 632772005933 H-loop/switch region; other site 632772005934 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 632772005935 Coenzyme A binding pocket [chemical binding]; other site 632772005936 Secretory lipase; Region: LIP; pfam03583 632772005937 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 632772005938 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 632772005939 active site 632772005940 nucleophile elbow; other site 632772005941 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 632772005942 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 632772005943 acyl-activating enzyme (AAE) consensus motif; other site 632772005944 putative AMP binding site [chemical binding]; other site 632772005945 putative active site [active] 632772005946 putative CoA binding site [chemical binding]; other site 632772005947 Transcriptional regulators [Transcription]; Region: MarR; COG1846 632772005948 MarR family; Region: MarR_2; pfam12802 632772005949 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 632772005950 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 632772005951 Coenzyme A binding pocket [chemical binding]; other site 632772005952 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 632772005953 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 632772005954 putative hydrophobic ligand binding site [chemical binding]; other site 632772005955 SWIM zinc finger; Region: SWIM; pfam04434 632772005956 MoxR-like ATPases [General function prediction only]; Region: COG0714 632772005957 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 632772005958 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 632772005959 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 632772005960 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 632772005961 metal ion-dependent adhesion site (MIDAS); other site 632772005962 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 632772005963 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 632772005964 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 632772005965 active site 632772005966 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 632772005967 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772005968 active site 632772005969 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 632772005970 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 632772005971 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 632772005972 active site 632772005973 nucleotide binding site [chemical binding]; other site 632772005974 HIGH motif; other site 632772005975 KMSKS motif; other site 632772005976 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 632772005977 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 632772005978 nudix motif; other site 632772005979 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 632772005980 Asp23 family; Region: Asp23; pfam03780 632772005981 Asp23 family; Region: Asp23; pfam03780 632772005982 YCII-related domain; Region: YCII; cl00999 632772005983 elongation factor Tu; Reviewed; Region: PRK00049 632772005984 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 632772005985 G1 box; other site 632772005986 GEF interaction site [polypeptide binding]; other site 632772005987 GTP/Mg2+ binding site [chemical binding]; other site 632772005988 Switch I region; other site 632772005989 G2 box; other site 632772005990 G3 box; other site 632772005991 Switch II region; other site 632772005992 G4 box; other site 632772005993 G5 box; other site 632772005994 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 632772005995 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 632772005996 Antibiotic Binding Site [chemical binding]; other site 632772005997 elongation factor G; Reviewed; Region: PRK00007 632772005998 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 632772005999 G1 box; other site 632772006000 putative GEF interaction site [polypeptide binding]; other site 632772006001 GTP/Mg2+ binding site [chemical binding]; other site 632772006002 Switch I region; other site 632772006003 G2 box; other site 632772006004 G3 box; other site 632772006005 Switch II region; other site 632772006006 G4 box; other site 632772006007 G5 box; other site 632772006008 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 632772006009 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 632772006010 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 632772006011 30S ribosomal protein S7; Validated; Region: PRK05302 632772006012 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 632772006013 S17 interaction site [polypeptide binding]; other site 632772006014 S8 interaction site; other site 632772006015 16S rRNA interaction site [nucleotide binding]; other site 632772006016 streptomycin interaction site [chemical binding]; other site 632772006017 23S rRNA interaction site [nucleotide binding]; other site 632772006018 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 632772006019 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 632772006020 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 632772006021 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772006022 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772006023 enoyl-CoA hydratase; Provisional; Region: PRK07827 632772006024 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772006025 substrate binding site [chemical binding]; other site 632772006026 oxyanion hole (OAH) forming residues; other site 632772006027 trimer interface [polypeptide binding]; other site 632772006028 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772006029 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 632772006030 active site 632772006031 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 632772006032 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 632772006033 ATP-grasp domain; Region: ATP-grasp_4; cl17255 632772006034 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 632772006035 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 632772006036 carboxyltransferase (CT) interaction site; other site 632772006037 biotinylation site [posttranslational modification]; other site 632772006038 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 632772006039 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 632772006040 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 632772006041 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772006042 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772006043 active site 632772006044 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 632772006045 TIGR03084 family protein; Region: TIGR03084 632772006046 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 632772006047 Wyosine base formation; Region: Wyosine_form; pfam08608 632772006048 short chain dehydrogenase; Provisional; Region: PRK05866 632772006049 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772006050 NAD(P) binding site [chemical binding]; other site 632772006051 active site 632772006052 enoyl-CoA hydratase; Provisional; Region: PRK09245 632772006053 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772006054 substrate binding site [chemical binding]; other site 632772006055 oxyanion hole (OAH) forming residues; other site 632772006056 trimer interface [polypeptide binding]; other site 632772006057 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 632772006058 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 632772006059 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 632772006060 Zn binding site [ion binding]; other site 632772006061 hypothetical protein; Provisional; Region: PRK08244 632772006062 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 632772006063 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 632772006064 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772006065 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772006066 cyclase homology domain; Region: CHD; cd07302 632772006067 nucleotidyl binding site; other site 632772006068 metal binding site [ion binding]; metal-binding site 632772006069 dimer interface [polypeptide binding]; other site 632772006070 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 632772006071 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 632772006072 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 632772006073 catalytic residue [active] 632772006074 Pirin-related protein [General function prediction only]; Region: COG1741 632772006075 Pirin; Region: Pirin; pfam02678 632772006076 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 632772006077 MarR family; Region: MarR_2; pfam12802 632772006078 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 632772006079 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 632772006080 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772006081 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632772006082 putative substrate translocation pore; other site 632772006083 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772006084 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 632772006085 MarR family; Region: MarR_2; pfam12802 632772006086 Ferredoxin [Energy production and conversion]; Region: COG1146 632772006087 4Fe-4S binding domain; Region: Fer4; pfam00037 632772006088 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 632772006089 ferredoxin-NADP+ reductase; Region: PLN02852 632772006090 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 632772006091 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 632772006092 active site 632772006093 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 632772006094 active site 2 [active] 632772006095 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 632772006096 salt bridge; other site 632772006097 non-specific DNA binding site [nucleotide binding]; other site 632772006098 sequence-specific DNA binding site [nucleotide binding]; other site 632772006099 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 632772006100 active site 632772006101 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 632772006102 catalytic tetrad [active] 632772006103 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 632772006104 catalytic core [active] 632772006105 Peptidase family M23; Region: Peptidase_M23; pfam01551 632772006106 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 632772006107 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 632772006108 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 632772006109 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 632772006110 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 632772006111 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 632772006112 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 632772006113 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 632772006114 G-loop; other site 632772006115 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 632772006116 DNA binding site [nucleotide binding] 632772006117 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 632772006118 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 632772006119 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 632772006120 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 632772006121 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 632772006122 RPB10 interaction site [polypeptide binding]; other site 632772006123 RPB1 interaction site [polypeptide binding]; other site 632772006124 RPB11 interaction site [polypeptide binding]; other site 632772006125 RPB3 interaction site [polypeptide binding]; other site 632772006126 RPB12 interaction site [polypeptide binding]; other site 632772006127 MMPL family; Region: MMPL; pfam03176 632772006128 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 632772006129 mce related protein; Region: MCE; pfam02470 632772006130 mce related protein; Region: MCE; pfam02470 632772006131 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 632772006132 mce related protein; Region: MCE; pfam02470 632772006133 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 632772006134 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 632772006135 mce related protein; Region: MCE; pfam02470 632772006136 mce related protein; Region: MCE; pfam02470 632772006137 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 632772006138 mce related protein; Region: MCE; pfam02470 632772006139 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 632772006140 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 632772006141 Permease; Region: Permease; pfam02405 632772006142 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 632772006143 Permease; Region: Permease; pfam02405 632772006144 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 632772006145 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 632772006146 Walker A/P-loop; other site 632772006147 ATP binding site [chemical binding]; other site 632772006148 Q-loop/lid; other site 632772006149 ABC transporter signature motif; other site 632772006150 Walker B; other site 632772006151 D-loop; other site 632772006152 H-loop/switch region; other site 632772006153 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 632772006154 core dimer interface [polypeptide binding]; other site 632772006155 peripheral dimer interface [polypeptide binding]; other site 632772006156 L10 interface [polypeptide binding]; other site 632772006157 L11 interface [polypeptide binding]; other site 632772006158 putative EF-Tu interaction site [polypeptide binding]; other site 632772006159 putative EF-G interaction site [polypeptide binding]; other site 632772006160 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 632772006161 23S rRNA interface [nucleotide binding]; other site 632772006162 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 632772006163 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772006164 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632772006165 putative substrate translocation pore; other site 632772006166 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772006167 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 632772006168 mRNA/rRNA interface [nucleotide binding]; other site 632772006169 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 632772006170 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 632772006171 23S rRNA interface [nucleotide binding]; other site 632772006172 L7/L12 interface [polypeptide binding]; other site 632772006173 putative thiostrepton binding site; other site 632772006174 L25 interface [polypeptide binding]; other site 632772006175 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 632772006176 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 632772006177 putative homodimer interface [polypeptide binding]; other site 632772006178 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 632772006179 heterodimer interface [polypeptide binding]; other site 632772006180 homodimer interface [polypeptide binding]; other site 632772006181 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 632772006182 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 632772006183 active site 632772006184 catalytic site [active] 632772006185 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 632772006186 active site 632772006187 catalytic site [active] 632772006188 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 632772006189 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 632772006190 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 632772006191 heat shock protein HtpX; Provisional; Region: PRK03072 632772006192 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 632772006193 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 632772006194 substrate binding pocket [chemical binding]; other site 632772006195 chain length determination region; other site 632772006196 substrate-Mg2+ binding site; other site 632772006197 catalytic residues [active] 632772006198 aspartate-rich region 1; other site 632772006199 active site lid residues [active] 632772006200 aspartate-rich region 2; other site 632772006201 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 632772006202 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 632772006203 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 632772006204 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772006205 S-adenosylmethionine binding site [chemical binding]; other site 632772006206 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 632772006207 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 632772006208 NAD(P) binding site [chemical binding]; other site 632772006209 catalytic residues [active] 632772006210 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 632772006211 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 632772006212 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 632772006213 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 632772006214 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 632772006215 dimer interface [polypeptide binding]; other site 632772006216 tetramer interface [polypeptide binding]; other site 632772006217 PYR/PP interface [polypeptide binding]; other site 632772006218 TPP binding site [chemical binding]; other site 632772006219 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 632772006220 TPP-binding site; other site 632772006221 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 632772006222 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 632772006223 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 632772006224 FAD binding pocket [chemical binding]; other site 632772006225 FAD binding motif [chemical binding]; other site 632772006226 phosphate binding motif [ion binding]; other site 632772006227 NAD binding pocket [chemical binding]; other site 632772006228 O-succinylbenzoate synthase; Provisional; Region: PRK02901 632772006229 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 632772006230 active site 632772006231 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 632772006232 CoenzymeA binding site [chemical binding]; other site 632772006233 subunit interaction site [polypeptide binding]; other site 632772006234 PHB binding site; other site 632772006235 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772006236 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 632772006237 substrate binding site [chemical binding]; other site 632772006238 oxyanion hole (OAH) forming residues; other site 632772006239 trimer interface [polypeptide binding]; other site 632772006240 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 632772006241 Sulfatase; Region: Sulfatase; pfam00884 632772006242 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 632772006243 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 632772006244 active site 632772006245 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 632772006246 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 632772006247 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 632772006248 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772006249 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 632772006250 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772006251 acyl-activating enzyme (AAE) consensus motif; other site 632772006252 acyl-activating enzyme (AAE) consensus motif; other site 632772006253 AMP binding site [chemical binding]; other site 632772006254 active site 632772006255 CoA binding site [chemical binding]; other site 632772006256 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 632772006257 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632772006258 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 632772006259 Walker A/P-loop; other site 632772006260 ATP binding site [chemical binding]; other site 632772006261 Q-loop/lid; other site 632772006262 ABC transporter signature motif; other site 632772006263 Walker B; other site 632772006264 D-loop; other site 632772006265 H-loop/switch region; other site 632772006266 ABC-2 type transporter; Region: ABC2_membrane; cl17235 632772006267 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 632772006268 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 632772006269 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 632772006270 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 632772006271 homotrimer interaction site [polypeptide binding]; other site 632772006272 putative active site [active] 632772006273 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 632772006274 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 632772006275 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 632772006276 Transcriptional regulator [Transcription]; Region: IclR; COG1414 632772006277 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 632772006278 Bacterial transcriptional regulator; Region: IclR; pfam01614 632772006279 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 632772006280 DNA binding site [nucleotide binding] 632772006281 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 632772006282 Predicted ATPase [General function prediction only]; Region: COG3903 632772006283 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 632772006284 Membrane protein of unknown function; Region: DUF360; pfam04020 632772006285 Clp amino terminal domain; Region: Clp_N; pfam02861 632772006286 Clp amino terminal domain; Region: Clp_N; pfam02861 632772006287 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 632772006288 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 632772006289 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 632772006290 putative acyl-acceptor binding pocket; other site 632772006291 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 632772006292 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 632772006293 Coenzyme A binding pocket [chemical binding]; other site 632772006294 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 632772006295 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 632772006296 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 632772006297 catalytic residue [active] 632772006298 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 632772006299 DNA binding residues [nucleotide binding] 632772006300 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 632772006301 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 632772006302 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 632772006303 ResB-like family; Region: ResB; pfam05140 632772006304 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 632772006305 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 632772006306 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 632772006307 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 632772006308 catalytic residues [active] 632772006309 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 632772006310 catalytic core [active] 632772006311 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 632772006312 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 632772006313 inhibitor-cofactor binding pocket; inhibition site 632772006314 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632772006315 catalytic residue [active] 632772006316 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 632772006317 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 632772006318 dimer interface [polypeptide binding]; other site 632772006319 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 632772006320 active site 632772006321 Fe binding site [ion binding]; other site 632772006322 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 632772006323 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 632772006324 AsnC family; Region: AsnC_trans_reg; pfam01037 632772006325 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 632772006326 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 632772006327 Domain of unknown function (DUF427); Region: DUF427; pfam04248 632772006328 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 632772006329 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772006330 active site 632772006331 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 632772006332 dimer interface [polypeptide binding]; other site 632772006333 active site 632772006334 Schiff base residues; other site 632772006335 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 632772006336 homodimer interface [polypeptide binding]; other site 632772006337 active site 632772006338 SAM binding site [chemical binding]; other site 632772006339 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 632772006340 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 632772006341 active site 632772006342 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 632772006343 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 632772006344 domain interfaces; other site 632772006345 active site 632772006346 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 632772006347 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 632772006348 tRNA; other site 632772006349 putative tRNA binding site [nucleotide binding]; other site 632772006350 putative NADP binding site [chemical binding]; other site 632772006351 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 632772006352 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 632772006353 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 632772006354 CoA binding domain; Region: CoA_binding; pfam02629 632772006355 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 632772006356 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 632772006357 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 632772006358 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 632772006359 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 632772006360 putative acyl-acceptor binding pocket; other site 632772006361 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 632772006362 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 632772006363 putative NAD(P) binding site [chemical binding]; other site 632772006364 active site 632772006365 putative substrate binding site [chemical binding]; other site 632772006366 DNA binding domain, excisionase family; Region: excise; TIGR01764 632772006367 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 632772006368 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 632772006369 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 632772006370 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 632772006371 active site 2 [active] 632772006372 active site 1 [active] 632772006373 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 632772006374 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 632772006375 DNA binding residues [nucleotide binding] 632772006376 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 632772006377 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 632772006378 exopolyphosphatase; Region: exo_poly_only; TIGR03706 632772006379 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 632772006380 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 632772006381 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632772006382 active site 632772006383 phosphorylation site [posttranslational modification] 632772006384 intermolecular recognition site; other site 632772006385 dimerization interface [polypeptide binding]; other site 632772006386 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 632772006387 DNA binding site [nucleotide binding] 632772006388 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 632772006389 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 632772006390 dimer interface [polypeptide binding]; other site 632772006391 phosphorylation site [posttranslational modification] 632772006392 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632772006393 ATP binding site [chemical binding]; other site 632772006394 Mg2+ binding site [ion binding]; other site 632772006395 G-X-G motif; other site 632772006396 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 632772006397 catalytic core [active] 632772006398 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 632772006399 4-coumarate--CoA ligase; Region: PLN02246 632772006400 4-Coumarate-CoA Ligase (4CL); Region: 4CL; cd05904 632772006401 acyl-activating enzyme (AAE) consensus motif; other site 632772006402 active site 632772006403 putative CoA binding site [chemical binding]; other site 632772006404 AMP binding site [chemical binding]; other site 632772006405 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 632772006406 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 632772006407 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 632772006408 putative ADP-binding pocket [chemical binding]; other site 632772006409 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 632772006410 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 632772006411 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 632772006412 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 632772006413 CoenzymeA binding site [chemical binding]; other site 632772006414 subunit interaction site [polypeptide binding]; other site 632772006415 PHB binding site; other site 632772006416 Tocopherol cyclase; Region: Tocopherol_cycl; cl14571 632772006417 Isochorismatase family; Region: Isochorismatase; pfam00857 632772006418 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 632772006419 catalytic triad [active] 632772006420 conserved cis-peptide bond; other site 632772006421 Protein of unknown function (DUF742); Region: DUF742; pfam05331 632772006422 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 632772006423 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 632772006424 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 632772006425 metabolite-proton symporter; Region: 2A0106; TIGR00883 632772006426 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772006427 putative substrate translocation pore; other site 632772006428 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 632772006429 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 632772006430 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 632772006431 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772006432 NAD(P) binding site [chemical binding]; other site 632772006433 active site 632772006434 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 632772006435 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 632772006436 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 632772006437 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 632772006438 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 632772006439 FAD binding domain; Region: FAD_binding_4; pfam01565 632772006440 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 632772006441 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 632772006442 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 632772006443 TROVE domain; Region: TROVE; pfam05731 632772006444 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 632772006445 metal ion-dependent adhesion site (MIDAS); other site 632772006446 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 632772006447 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 632772006448 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 632772006449 intersubunit interface [polypeptide binding]; other site 632772006450 active site 632772006451 catalytic residue [active] 632772006452 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772006453 S-adenosylmethionine binding site [chemical binding]; other site 632772006454 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 632772006455 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 632772006456 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 632772006457 putative active site [active] 632772006458 putative substrate binding site [chemical binding]; other site 632772006459 putative cosubstrate binding site; other site 632772006460 catalytic site [active] 632772006461 Predicted amidohydrolase [General function prediction only]; Region: COG0388 632772006462 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 632772006463 putative active site [active] 632772006464 catalytic triad [active] 632772006465 putative dimer interface [polypeptide binding]; other site 632772006466 enoyl-CoA hydratase; Provisional; Region: PRK08260 632772006467 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772006468 substrate binding site [chemical binding]; other site 632772006469 oxyanion hole (OAH) forming residues; other site 632772006470 trimer interface [polypeptide binding]; other site 632772006471 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 632772006472 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772006473 acyl-activating enzyme (AAE) consensus motif; other site 632772006474 AMP binding site [chemical binding]; other site 632772006475 active site 632772006476 CoA binding site [chemical binding]; other site 632772006477 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772006478 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 632772006479 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 632772006480 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 632772006481 FMN-binding pocket [chemical binding]; other site 632772006482 flavin binding motif; other site 632772006483 phosphate binding motif [ion binding]; other site 632772006484 beta-alpha-beta structure motif; other site 632772006485 NAD binding pocket [chemical binding]; other site 632772006486 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 632772006487 catalytic loop [active] 632772006488 iron binding site [ion binding]; other site 632772006489 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 632772006490 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772006491 NAD(P) binding site [chemical binding]; other site 632772006492 active site 632772006493 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 632772006494 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 632772006495 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772006496 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 632772006497 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 632772006498 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 632772006499 NAD binding site [chemical binding]; other site 632772006500 catalytic residues [active] 632772006501 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 632772006502 classical (c) SDRs; Region: SDR_c; cd05233 632772006503 NAD(P) binding site [chemical binding]; other site 632772006504 active site 632772006505 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 632772006506 Coenzyme A binding pocket [chemical binding]; other site 632772006507 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 632772006508 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 632772006509 [2Fe-2S] cluster binding site [ion binding]; other site 632772006510 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887 632772006511 putative alpha subunit interface [polypeptide binding]; other site 632772006512 putative active site [active] 632772006513 putative substrate binding site [chemical binding]; other site 632772006514 Fe binding site [ion binding]; other site 632772006515 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772006516 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772006517 active site 632772006518 Lipase (class 2); Region: Lipase_2; pfam01674 632772006519 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 632772006520 CoA-transferase family III; Region: CoA_transf_3; pfam02515 632772006521 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 632772006522 CoA-transferase family III; Region: CoA_transf_3; pfam02515 632772006523 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 632772006524 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 632772006525 NAD binding site [chemical binding]; other site 632772006526 catalytic residues [active] 632772006527 lipid-transfer protein; Provisional; Region: PRK07855 632772006528 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 632772006529 active site 632772006530 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 632772006531 DUF35 OB-fold domain; Region: DUF35; pfam01796 632772006532 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 632772006533 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 632772006534 active site 632772006535 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 632772006536 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 632772006537 enoyl-CoA hydratase; Provisional; Region: PRK05864 632772006538 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772006539 substrate binding site [chemical binding]; other site 632772006540 oxyanion hole (OAH) forming residues; other site 632772006541 trimer interface [polypeptide binding]; other site 632772006542 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 632772006543 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772006544 NAD(P) binding site [chemical binding]; other site 632772006545 active site 632772006546 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772006547 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 632772006548 NAD(P) binding site [chemical binding]; other site 632772006549 active site 632772006550 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 632772006551 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772006552 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 632772006553 acyl-activating enzyme (AAE) consensus motif; other site 632772006554 acyl-activating enzyme (AAE) consensus motif; other site 632772006555 putative AMP binding site [chemical binding]; other site 632772006556 putative active site [active] 632772006557 putative CoA binding site [chemical binding]; other site 632772006558 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 632772006559 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 632772006560 molybdopterin cofactor binding site; other site 632772006561 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 632772006562 molybdopterin cofactor binding site; other site 632772006563 Ferredoxin [Energy production and conversion]; Region: COG1146 632772006564 4Fe-4S binding domain; Region: Fer4; pfam00037 632772006565 ferredoxin-NADP+ reductase; Region: PLN02852 632772006566 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 632772006567 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 632772006568 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 632772006569 molybdopterin cofactor binding site; other site 632772006570 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 632772006571 molybdopterin cofactor binding site; other site 632772006572 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 632772006573 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 632772006574 molybdopterin cofactor binding site; other site 632772006575 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 632772006576 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 632772006577 molybdopterin cofactor binding site; other site 632772006578 benzoate transport; Region: 2A0115; TIGR00895 632772006579 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772006580 putative substrate translocation pore; other site 632772006581 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772006582 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 632772006583 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 632772006584 acyl-activating enzyme (AAE) consensus motif; other site 632772006585 putative AMP binding site [chemical binding]; other site 632772006586 putative active site [active] 632772006587 putative CoA binding site [chemical binding]; other site 632772006588 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 632772006589 CoA-transferase family III; Region: CoA_transf_3; pfam02515 632772006590 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 632772006591 CoenzymeA binding site [chemical binding]; other site 632772006592 subunit interaction site [polypeptide binding]; other site 632772006593 PHB binding site; other site 632772006594 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 632772006595 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772006596 substrate binding site [chemical binding]; other site 632772006597 oxyanion hole (OAH) forming residues; other site 632772006598 trimer interface [polypeptide binding]; other site 632772006599 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 632772006600 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 632772006601 [2Fe-2S] cluster binding site [ion binding]; other site 632772006602 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887 632772006603 putative alpha subunit interface [polypeptide binding]; other site 632772006604 putative active site [active] 632772006605 putative substrate binding site [chemical binding]; other site 632772006606 Fe binding site [ion binding]; other site 632772006607 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772006608 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772006609 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 632772006610 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 632772006611 mce related protein; Region: MCE; pfam02470 632772006612 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 632772006613 mce related protein; Region: MCE; pfam02470 632772006614 mce related protein; Region: MCE; pfam02470 632772006615 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 632772006616 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 632772006617 mce related protein; Region: MCE; pfam02470 632772006618 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 632772006619 Permease; Region: Permease; pfam02405 632772006620 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 632772006621 Permease; Region: Permease; pfam02405 632772006622 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 632772006623 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 632772006624 Walker A/P-loop; other site 632772006625 ATP binding site [chemical binding]; other site 632772006626 Q-loop/lid; other site 632772006627 ABC transporter signature motif; other site 632772006628 Walker B; other site 632772006629 D-loop; other site 632772006630 H-loop/switch region; other site 632772006631 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772006632 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772006633 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 632772006634 Cytochrome P450; Region: p450; cl12078 632772006635 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 632772006636 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 632772006637 classical (c) SDRs; Region: SDR_c; cd05233 632772006638 NAD(P) binding site [chemical binding]; other site 632772006639 active site 632772006640 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 632772006641 4Fe-4S binding domain; Region: Fer4; pfam00037 632772006642 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 632772006643 ferredoxin-NADP+ reductase; Region: PLN02852 632772006644 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 632772006645 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 632772006646 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 632772006647 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 632772006648 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778 632772006649 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 632772006650 DNA binding residues [nucleotide binding] 632772006651 putative dimer interface [polypeptide binding]; other site 632772006652 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 632772006653 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 632772006654 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 632772006655 non-specific DNA binding site [nucleotide binding]; other site 632772006656 salt bridge; other site 632772006657 sequence-specific DNA binding site [nucleotide binding]; other site 632772006658 Predicted membrane protein [Function unknown]; Region: COG2733 632772006659 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772006660 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772006661 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 632772006662 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 632772006663 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 632772006664 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 632772006665 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 632772006666 putative ADP-binding pocket [chemical binding]; other site 632772006667 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 632772006668 anti sigma factor interaction site; other site 632772006669 regulatory phosphorylation site [posttranslational modification]; other site 632772006670 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 632772006671 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 632772006672 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 632772006673 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 632772006674 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632772006675 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 632772006676 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 632772006677 DNA binding residues [nucleotide binding] 632772006678 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 632772006679 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 632772006680 putative NAD(P) binding site [chemical binding]; other site 632772006681 putative substrate binding site [chemical binding]; other site 632772006682 catalytic Zn binding site [ion binding]; other site 632772006683 structural Zn binding site [ion binding]; other site 632772006684 dimer interface [polypeptide binding]; other site 632772006685 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 632772006686 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 632772006687 THF binding site; other site 632772006688 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 632772006689 substrate binding site [chemical binding]; other site 632772006690 THF binding site; other site 632772006691 zinc-binding site [ion binding]; other site 632772006692 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 632772006693 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 632772006694 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 632772006695 isocitrate lyase; Provisional; Region: PRK15063 632772006696 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 632772006697 tetramer interface [polypeptide binding]; other site 632772006698 active site 632772006699 Mg2+/Mn2+ binding site [ion binding]; other site 632772006700 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 632772006701 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 632772006702 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 632772006703 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 632772006704 non-specific DNA binding site [nucleotide binding]; other site 632772006705 salt bridge; other site 632772006706 sequence-specific DNA binding site [nucleotide binding]; other site 632772006707 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 632772006708 Domain of unknown function (DUF955); Region: DUF955; pfam06114 632772006709 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 632772006710 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 632772006711 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 632772006712 putative ligand binding site [chemical binding]; other site 632772006713 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 632772006714 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 632772006715 TM-ABC transporter signature motif; other site 632772006716 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 632772006717 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 632772006718 TM-ABC transporter signature motif; other site 632772006719 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 632772006720 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 632772006721 Walker A/P-loop; other site 632772006722 ATP binding site [chemical binding]; other site 632772006723 Q-loop/lid; other site 632772006724 ABC transporter signature motif; other site 632772006725 Walker B; other site 632772006726 D-loop; other site 632772006727 H-loop/switch region; other site 632772006728 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 632772006729 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 632772006730 Walker A/P-loop; other site 632772006731 ATP binding site [chemical binding]; other site 632772006732 Q-loop/lid; other site 632772006733 ABC transporter signature motif; other site 632772006734 Walker B; other site 632772006735 D-loop; other site 632772006736 H-loop/switch region; other site 632772006737 Transcriptional regulators [Transcription]; Region: GntR; COG1802 632772006738 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772006739 DNA-binding site [nucleotide binding]; DNA binding site 632772006740 FCD domain; Region: FCD; pfam07729 632772006741 Uncharacterized conserved protein [Function unknown]; Region: COG2128 632772006742 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 632772006743 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 632772006744 urea carboxylase; Region: urea_carbox; TIGR02712 632772006745 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 632772006746 ATP-grasp domain; Region: ATP-grasp_4; cl17255 632772006747 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 632772006748 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 632772006749 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 632772006750 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 632772006751 carboxyltransferase (CT) interaction site; other site 632772006752 biotinylation site [posttranslational modification]; other site 632772006753 allophanate hydrolase; Provisional; Region: PRK08186 632772006754 Amidase; Region: Amidase; cl11426 632772006755 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 632772006756 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 632772006757 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 632772006758 NADP binding site [chemical binding]; other site 632772006759 Predicted transcriptional regulators [Transcription]; Region: COG1733 632772006760 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 632772006761 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 632772006762 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 632772006763 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 632772006764 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 632772006765 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 632772006766 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 632772006767 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 632772006768 Putative esterase; Region: Esterase; pfam00756 632772006769 PspC domain; Region: PspC; pfam04024 632772006770 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 632772006771 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 632772006772 ring oligomerisation interface [polypeptide binding]; other site 632772006773 ATP/Mg binding site [chemical binding]; other site 632772006774 stacking interactions; other site 632772006775 hinge regions; other site 632772006776 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 632772006777 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 632772006778 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632772006779 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 632772006780 Ligand Binding Site [chemical binding]; other site 632772006781 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 632772006782 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 632772006783 putative NAD(P) binding site [chemical binding]; other site 632772006784 putative substrate binding site [chemical binding]; other site 632772006785 catalytic Zn binding site [ion binding]; other site 632772006786 structural Zn binding site [ion binding]; other site 632772006787 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 632772006788 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 632772006789 hydroxyglutarate oxidase; Provisional; Region: PRK11728 632772006790 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 632772006791 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 632772006792 active sites [active] 632772006793 tetramer interface [polypeptide binding]; other site 632772006794 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 632772006795 hydrophobic ligand binding site; other site 632772006796 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 632772006797 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 632772006798 DNA binding residues [nucleotide binding] 632772006799 drug binding residues [chemical binding]; other site 632772006800 dimer interface [polypeptide binding]; other site 632772006801 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 632772006802 beta-clamp/clamp loader binding surface; other site 632772006803 beta-clamp/translesion DNA polymerase binding surface; other site 632772006804 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 632772006805 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 632772006806 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 632772006807 Cell division protein 48 (CDC48) N-terminal domain; Region: CDC48_N; smart01073 632772006808 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 632772006809 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 632772006810 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632772006811 Walker A motif; other site 632772006812 ATP binding site [chemical binding]; other site 632772006813 Walker B motif; other site 632772006814 arginine finger; other site 632772006815 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632772006816 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 632772006817 Walker A motif; other site 632772006818 ATP binding site [chemical binding]; other site 632772006819 Walker B motif; other site 632772006820 arginine finger; other site 632772006821 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 632772006822 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 632772006823 tetramer interface [polypeptide binding]; other site 632772006824 active site 632772006825 Mg2+/Mn2+ binding site [ion binding]; other site 632772006826 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 632772006827 nudix motif; other site 632772006828 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 632772006829 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 632772006830 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 632772006831 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 632772006832 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 632772006833 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 632772006834 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 632772006835 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK07948 632772006836 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 632772006837 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 632772006838 active site 632772006839 carboxylate-amine ligase; Provisional; Region: PRK13517 632772006840 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 632772006841 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 632772006842 E-class dimer interface [polypeptide binding]; other site 632772006843 P-class dimer interface [polypeptide binding]; other site 632772006844 active site 632772006845 Cu2+ binding site [ion binding]; other site 632772006846 Zn2+ binding site [ion binding]; other site 632772006847 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 632772006848 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 632772006849 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 632772006850 active site 632772006851 catalytic residues [active] 632772006852 metal binding site [ion binding]; metal-binding site 632772006853 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 632772006854 Coenzyme A binding pocket [chemical binding]; other site 632772006855 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 632772006856 putative catalytic site [active] 632772006857 putative phosphate binding site [ion binding]; other site 632772006858 active site 632772006859 metal binding site A [ion binding]; metal-binding site 632772006860 DNA binding site [nucleotide binding] 632772006861 putative AP binding site [nucleotide binding]; other site 632772006862 putative metal binding site B [ion binding]; other site 632772006863 Predicted acetyltransferase [General function prediction only]; Region: COG2388 632772006864 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 632772006865 ThiC-associated domain; Region: ThiC-associated; pfam13667 632772006866 ThiC family; Region: ThiC; pfam01964 632772006867 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 632772006868 dimer interface [polypeptide binding]; other site 632772006869 substrate binding site [chemical binding]; other site 632772006870 ATP binding site [chemical binding]; other site 632772006871 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 632772006872 cyclase homology domain; Region: CHD; cd07302 632772006873 nucleotidyl binding site; other site 632772006874 metal binding site [ion binding]; metal-binding site 632772006875 dimer interface [polypeptide binding]; other site 632772006876 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 632772006877 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 632772006878 PA/protease or protease-like domain interface [polypeptide binding]; other site 632772006879 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 632772006880 Peptidase family M28; Region: Peptidase_M28; pfam04389 632772006881 active site 632772006882 metal binding site [ion binding]; metal-binding site 632772006883 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 632772006884 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 632772006885 Walker A/P-loop; other site 632772006886 ATP binding site [chemical binding]; other site 632772006887 Q-loop/lid; other site 632772006888 ABC transporter signature motif; other site 632772006889 Walker B; other site 632772006890 D-loop; other site 632772006891 H-loop/switch region; other site 632772006892 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 632772006893 ThiS interaction site; other site 632772006894 putative active site [active] 632772006895 tetramer interface [polypeptide binding]; other site 632772006896 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 632772006897 thiS-thiF/thiG interaction site; other site 632772006898 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 632772006899 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 632772006900 thiamine phosphate binding site [chemical binding]; other site 632772006901 active site 632772006902 pyrophosphate binding site [ion binding]; other site 632772006903 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 632772006904 nudix motif; other site 632772006905 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 632772006906 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 632772006907 substrate binding pocket [chemical binding]; other site 632772006908 membrane-bound complex binding site; other site 632772006909 hinge residues; other site 632772006910 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 632772006911 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 632772006912 active site 632772006913 ATP binding site [chemical binding]; other site 632772006914 substrate binding site [chemical binding]; other site 632772006915 activation loop (A-loop); other site 632772006916 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 632772006917 propionate/acetate kinase; Provisional; Region: PRK12379 632772006918 phosphate acetyltransferase; Reviewed; Region: PRK05632 632772006919 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 632772006920 DRTGG domain; Region: DRTGG; pfam07085 632772006921 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 632772006922 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 632772006923 active site 632772006924 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 632772006925 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 632772006926 trimer interface [polypeptide binding]; other site 632772006927 active site 632772006928 substrate binding site [chemical binding]; other site 632772006929 CoA binding site [chemical binding]; other site 632772006930 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 632772006931 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 632772006932 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 632772006933 Domain of unknown function (DUF202); Region: DUF202; cl09954 632772006934 Predicted esterase [General function prediction only]; Region: COG0627 632772006935 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772006936 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 632772006937 acyl-activating enzyme (AAE) consensus motif; other site 632772006938 AMP binding site [chemical binding]; other site 632772006939 active site 632772006940 CoA binding site [chemical binding]; other site 632772006941 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772006942 Condensation domain; Region: Condensation; pfam00668 632772006943 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 632772006944 Condensation domain; Region: Condensation; pfam00668 632772006945 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 632772006946 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772006947 acyl-activating enzyme (AAE) consensus motif; other site 632772006948 AMP binding site [chemical binding]; other site 632772006949 active site 632772006950 CoA binding site [chemical binding]; other site 632772006951 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772006952 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 632772006953 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772006954 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772006955 acyl-activating enzyme (AAE) consensus motif; other site 632772006956 AMP binding site [chemical binding]; other site 632772006957 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772006958 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 632772006959 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 632772006960 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 632772006961 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 632772006962 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 632772006963 active site 632772006964 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772006965 Condensation domain; Region: Condensation; pfam00668 632772006966 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 632772006967 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772006968 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772006969 Condensation domain; Region: Condensation; pfam00668 632772006970 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 632772006971 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772006972 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772006973 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 632772006974 acyl-activating enzyme (AAE) consensus motif; other site 632772006975 AMP binding site [chemical binding]; other site 632772006976 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772006977 Condensation domain; Region: Condensation; pfam00668 632772006978 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 632772006979 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772006980 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772006981 acyl-activating enzyme (AAE) consensus motif; other site 632772006982 AMP binding site [chemical binding]; other site 632772006983 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772006984 Condensation domain; Region: Condensation; pfam00668 632772006985 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 632772006986 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772006987 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772006988 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772006989 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772006990 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 632772006991 acyl-activating enzyme (AAE) consensus motif; other site 632772006992 AMP binding site [chemical binding]; other site 632772006993 FkbH-like domain; Region: FkbH; TIGR01686 632772006994 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632772006995 active site 632772006996 motif I; other site 632772006997 motif II; other site 632772006998 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 632772006999 active site 632772007000 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal; Region: ACP_syn_III_C; cl17241 632772007001 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772007002 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 632772007003 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 632772007004 active site 632772007005 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 632772007006 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 632772007007 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 632772007008 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 632772007009 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 632772007010 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 632772007011 active site 632772007012 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 632772007013 non-prolyl cis peptide bond; other site 632772007014 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 632772007015 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 632772007016 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 632772007017 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 632772007018 Walker A/P-loop; other site 632772007019 ATP binding site [chemical binding]; other site 632772007020 Q-loop/lid; other site 632772007021 ABC transporter signature motif; other site 632772007022 Walker B; other site 632772007023 D-loop; other site 632772007024 H-loop/switch region; other site 632772007025 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 632772007026 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 632772007027 Walker A/P-loop; other site 632772007028 ATP binding site [chemical binding]; other site 632772007029 Q-loop/lid; other site 632772007030 ABC transporter signature motif; other site 632772007031 Walker B; other site 632772007032 D-loop; other site 632772007033 H-loop/switch region; other site 632772007034 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 632772007035 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 632772007036 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772007037 putative PBP binding loops; other site 632772007038 dimer interface [polypeptide binding]; other site 632772007039 ABC-ATPase subunit interface; other site 632772007040 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 632772007041 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772007042 dimer interface [polypeptide binding]; other site 632772007043 conserved gate region; other site 632772007044 putative PBP binding loops; other site 632772007045 ABC-ATPase subunit interface; other site 632772007046 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 632772007047 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 632772007048 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 632772007049 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 632772007050 active site 632772007051 non-prolyl cis peptide bond; other site 632772007052 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 632772007053 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 632772007054 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 632772007055 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 632772007056 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 632772007057 Coenzyme A binding pocket [chemical binding]; other site 632772007058 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 632772007059 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 632772007060 substrate binding pocket [chemical binding]; other site 632772007061 membrane-bound complex binding site; other site 632772007062 hinge residues; other site 632772007063 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 632772007064 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632772007065 Q-loop/lid; other site 632772007066 ABC transporter signature motif; other site 632772007067 Walker B; other site 632772007068 D-loop; other site 632772007069 H-loop/switch region; other site 632772007070 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 632772007071 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632772007072 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 632772007073 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772007074 dimer interface [polypeptide binding]; other site 632772007075 conserved gate region; other site 632772007076 putative PBP binding loops; other site 632772007077 ABC-ATPase subunit interface; other site 632772007078 hypothetical protein; Provisional; Region: PRK10621 632772007079 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 632772007080 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 632772007081 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632772007082 active site 632772007083 motif I; other site 632772007084 motif II; other site 632772007085 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632772007086 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 632772007087 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 632772007088 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 632772007089 homodimer interface [polypeptide binding]; other site 632772007090 substrate-cofactor binding pocket; other site 632772007091 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632772007092 catalytic residue [active] 632772007093 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 632772007094 active site residue [active] 632772007095 ferredoxin-NADP+ reductase; Region: PLN02852 632772007096 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 632772007097 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 632772007098 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 632772007099 active site 632772007100 Protein of unknown function (DUF456); Region: DUF456; pfam04306 632772007101 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 632772007102 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772007103 ATP-grasp domain; Region: ATP-grasp; pfam02222 632772007104 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 632772007105 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 632772007106 putative DNA binding site [nucleotide binding]; other site 632772007107 catalytic residue [active] 632772007108 putative H2TH interface [polypeptide binding]; other site 632772007109 putative catalytic residues [active] 632772007110 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 632772007111 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 632772007112 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 632772007113 active site 632772007114 SAM binding site [chemical binding]; other site 632772007115 homodimer interface [polypeptide binding]; other site 632772007116 thymidylate synthase; Reviewed; Region: thyA; PRK01827 632772007117 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 632772007118 dimerization interface [polypeptide binding]; other site 632772007119 active site 632772007120 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 632772007121 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 632772007122 folate binding site [chemical binding]; other site 632772007123 NADP+ binding site [chemical binding]; other site 632772007124 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 632772007125 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 632772007126 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 632772007127 gating phenylalanine in ion channel; other site 632772007128 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 632772007129 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 632772007130 GAF domain; Region: GAF_3; pfam13492 632772007131 GAF domain; Region: GAF_2; pfam13185 632772007132 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 632772007133 Histidine kinase; Region: HisKA_3; pfam07730 632772007134 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632772007135 ATP binding site [chemical binding]; other site 632772007136 Mg2+ binding site [ion binding]; other site 632772007137 G-X-G motif; other site 632772007138 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632772007139 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632772007140 active site 632772007141 phosphorylation site [posttranslational modification] 632772007142 intermolecular recognition site; other site 632772007143 dimerization interface [polypeptide binding]; other site 632772007144 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632772007145 DNA binding residues [nucleotide binding] 632772007146 dimerization interface [polypeptide binding]; other site 632772007147 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 632772007148 Ligand Binding Site [chemical binding]; other site 632772007149 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 632772007150 Ligand Binding Site [chemical binding]; other site 632772007151 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 632772007152 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 632772007153 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 632772007154 Ligand Binding Site [chemical binding]; other site 632772007155 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 632772007156 Ligand Binding Site [chemical binding]; other site 632772007157 Rrf2 family protein; Region: rrf2_super; TIGR00738 632772007158 Transcriptional regulator; Region: Rrf2; cl17282 632772007159 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 632772007160 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 632772007161 heme-binding site [chemical binding]; other site 632772007162 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 632772007163 FAD binding pocket [chemical binding]; other site 632772007164 FAD binding motif [chemical binding]; other site 632772007165 phosphate binding motif [ion binding]; other site 632772007166 beta-alpha-beta structure motif; other site 632772007167 NAD binding pocket [chemical binding]; other site 632772007168 Heme binding pocket [chemical binding]; other site 632772007169 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 632772007170 Peptidase family M23; Region: Peptidase_M23; pfam01551 632772007171 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 632772007172 Dienelactone hydrolase family; Region: DLH; pfam01738 632772007173 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 632772007174 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 632772007175 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 632772007176 active site 632772007177 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 632772007178 RNA/DNA hybrid binding site [nucleotide binding]; other site 632772007179 active site 632772007180 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 632772007181 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 632772007182 minor groove reading motif; other site 632772007183 helix-hairpin-helix signature motif; other site 632772007184 active site 632772007185 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; COG0310 632772007186 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 632772007187 PDGLE domain; Region: PDGLE; pfam13190 632772007188 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 632772007189 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 632772007190 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 632772007191 Walker A/P-loop; other site 632772007192 ATP binding site [chemical binding]; other site 632772007193 Q-loop/lid; other site 632772007194 ABC transporter signature motif; other site 632772007195 Walker B; other site 632772007196 D-loop; other site 632772007197 H-loop/switch region; other site 632772007198 Methyltransferase domain; Region: Methyltransf_31; pfam13847 632772007199 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772007200 S-adenosylmethionine binding site [chemical binding]; other site 632772007201 Transcriptional regulators [Transcription]; Region: MarR; COG1846 632772007202 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632772007203 dimerization interface [polypeptide binding]; other site 632772007204 putative DNA binding site [nucleotide binding]; other site 632772007205 putative Zn2+ binding site [ion binding]; other site 632772007206 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 632772007207 CoA-transferase family III; Region: CoA_transf_3; pfam02515 632772007208 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632772007209 putative DNA binding site [nucleotide binding]; other site 632772007210 putative Zn2+ binding site [ion binding]; other site 632772007211 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 632772007212 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772007213 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 632772007214 acyl-activating enzyme (AAE) consensus motif; other site 632772007215 acyl-activating enzyme (AAE) consensus motif; other site 632772007216 putative AMP binding site [chemical binding]; other site 632772007217 putative active site [active] 632772007218 putative CoA binding site [chemical binding]; other site 632772007219 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 632772007220 enoyl-CoA hydratase; Provisional; Region: PRK08252 632772007221 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772007222 substrate binding site [chemical binding]; other site 632772007223 oxyanion hole (OAH) forming residues; other site 632772007224 trimer interface [polypeptide binding]; other site 632772007225 Transcriptional regulator [Transcription]; Region: LysR; COG0583 632772007226 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 632772007227 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 632772007228 dimerization interface [polypeptide binding]; other site 632772007229 Transcriptional regulator [Transcription]; Region: LysR; COG0583 632772007230 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 632772007231 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 632772007232 dimerization interface [polypeptide binding]; other site 632772007233 enoyl-CoA hydratase; Provisional; Region: PRK06688 632772007234 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772007235 substrate binding site [chemical binding]; other site 632772007236 oxyanion hole (OAH) forming residues; other site 632772007237 trimer interface [polypeptide binding]; other site 632772007238 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 632772007239 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 632772007240 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772007241 acyl-activating enzyme (AAE) consensus motif; other site 632772007242 AMP binding site [chemical binding]; other site 632772007243 active site 632772007244 CoA binding site [chemical binding]; other site 632772007245 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772007246 NAD(P) binding site [chemical binding]; other site 632772007247 active site 632772007248 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 632772007249 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 632772007250 dimer interface [polypeptide binding]; other site 632772007251 active site 632772007252 D-galactonate transporter; Region: 2A0114; TIGR00893 632772007253 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772007254 putative substrate translocation pore; other site 632772007255 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772007256 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772007257 active site 632772007258 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 632772007259 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772007260 S-adenosylmethionine binding site [chemical binding]; other site 632772007261 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 632772007262 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 632772007263 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 632772007264 dimer interface [polypeptide binding]; other site 632772007265 phosphorylation site [posttranslational modification] 632772007266 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632772007267 ATP binding site [chemical binding]; other site 632772007268 Mg2+ binding site [ion binding]; other site 632772007269 G-X-G motif; other site 632772007270 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 632772007271 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632772007272 active site 632772007273 phosphorylation site [posttranslational modification] 632772007274 intermolecular recognition site; other site 632772007275 dimerization interface [polypeptide binding]; other site 632772007276 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 632772007277 DNA binding site [nucleotide binding] 632772007278 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 632772007279 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772007280 putative substrate translocation pore; other site 632772007281 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 632772007282 CoA-transferase family III; Region: CoA_transf_3; pfam02515 632772007283 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772007284 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772007285 active site 632772007286 Transcriptional regulators [Transcription]; Region: PurR; COG1609 632772007287 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 632772007288 DNA binding site [nucleotide binding] 632772007289 domain linker motif; other site 632772007290 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_7; cd06285 632772007291 putative dimerization interface [polypeptide binding]; other site 632772007292 putative ligand binding site [chemical binding]; other site 632772007293 acyl-CoA synthetase; Validated; Region: PRK08316 632772007294 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772007295 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 632772007296 acyl-activating enzyme (AAE) consensus motif; other site 632772007297 acyl-activating enzyme (AAE) consensus motif; other site 632772007298 putative active site [active] 632772007299 putative AMP binding site [chemical binding]; other site 632772007300 putative CoA binding site [chemical binding]; other site 632772007301 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772007302 enoyl-CoA hydratase; Validated; Region: PRK08139 632772007303 substrate binding site [chemical binding]; other site 632772007304 oxyanion hole (OAH) forming residues; other site 632772007305 trimer interface [polypeptide binding]; other site 632772007306 fumarylacetoacetase; Region: PLN02856 632772007307 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 632772007308 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 632772007309 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 632772007310 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 632772007311 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 632772007312 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772007313 D-galactonate transporter; Region: 2A0114; TIGR00893 632772007314 putative substrate translocation pore; other site 632772007315 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 632772007316 Predicted oxidoreductase [General function prediction only]; Region: COG3573 632772007317 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 632772007318 classical (c) SDRs; Region: SDR_c; cd05233 632772007319 NAD(P) binding site [chemical binding]; other site 632772007320 active site 632772007321 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 632772007322 classical (c) SDRs; Region: SDR_c; cd05233 632772007323 NAD(P) binding site [chemical binding]; other site 632772007324 active site 632772007325 SnoaL-like domain; Region: SnoaL_4; pfam13577 632772007326 Transcriptional regulator [Transcription]; Region: IclR; COG1414 632772007327 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 632772007328 spermidine synthase; Provisional; Region: PRK03612 632772007329 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772007330 S-adenosylmethionine binding site [chemical binding]; other site 632772007331 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 632772007332 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 632772007333 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 632772007334 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 632772007335 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 632772007336 Isochorismatase family; Region: Isochorismatase; pfam00857 632772007337 catalytic triad [active] 632772007338 conserved cis-peptide bond; other site 632772007339 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772007340 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 632772007341 acyl-activating enzyme (AAE) consensus motif; other site 632772007342 AMP binding site [chemical binding]; other site 632772007343 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 632772007344 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772007345 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772007346 acyl-activating enzyme (AAE) consensus motif; other site 632772007347 AMP binding site [chemical binding]; other site 632772007348 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772007349 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 632772007350 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 632772007351 siderophore binding site; other site 632772007352 H+ Antiporter protein; Region: 2A0121; TIGR00900 632772007353 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772007354 putative substrate translocation pore; other site 632772007355 Phosphopantetheine attachment site; Region: PP-binding; cl09936 632772007356 Protein of unknown function (DUF3533); Region: DUF3533; pfam12051 632772007357 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 632772007358 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 632772007359 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 632772007360 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 632772007361 active site 632772007362 DNA binding site [nucleotide binding] 632772007363 catalytic site [active] 632772007364 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 632772007365 AlkA N-terminal domain; Region: AlkA_N; pfam06029 632772007366 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 632772007367 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 632772007368 minor groove reading motif; other site 632772007369 helix-hairpin-helix signature motif; other site 632772007370 substrate binding pocket [chemical binding]; other site 632772007371 active site 632772007372 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 632772007373 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 632772007374 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 632772007375 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 632772007376 DNA binding site [nucleotide binding] 632772007377 active site 632772007378 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 632772007379 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632772007380 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 632772007381 DNA binding residues [nucleotide binding] 632772007382 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 632772007383 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 632772007384 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 632772007385 DNA binding site [nucleotide binding] 632772007386 active site 632772007387 short chain dehydrogenase; Provisional; Region: PRK07326 632772007388 classical (c) SDRs; Region: SDR_c; cd05233 632772007389 NAD(P) binding site [chemical binding]; other site 632772007390 active site 632772007391 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 632772007392 putative active site [active] 632772007393 putative substrate binding site [chemical binding]; other site 632772007394 ATP binding site [chemical binding]; other site 632772007395 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772007396 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 632772007397 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 632772007398 active site 632772007399 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772007400 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772007401 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 632772007402 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 632772007403 hydrophobic ligand binding site; other site 632772007404 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 632772007405 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 632772007406 NAD(P) binding site [chemical binding]; other site 632772007407 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 632772007408 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772007409 NAD(P) binding site [chemical binding]; other site 632772007410 active site 632772007411 classical (c) SDRs; Region: SDR_c; cd05233 632772007412 short chain dehydrogenase; Provisional; Region: PRK05650 632772007413 NAD(P) binding site [chemical binding]; other site 632772007414 active site 632772007415 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772007416 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772007417 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 632772007418 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772007419 NAD(P) binding site [chemical binding]; other site 632772007420 active site 632772007421 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772007422 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772007423 active site 632772007424 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772007425 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772007426 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 632772007427 active site 632772007428 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 632772007429 EspG family; Region: ESX-1_EspG; pfam14011 632772007430 Domain of unknown function (DUF309); Region: DUF309; pfam03745 632772007431 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 632772007432 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 632772007433 Cytochrome P450; Region: p450; cl12078 632772007434 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 632772007435 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 632772007436 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 632772007437 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 632772007438 MarR family; Region: MarR_2; pfam12802 632772007439 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772007440 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632772007441 putative substrate translocation pore; other site 632772007442 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772007443 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 632772007444 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 632772007445 ATP-binding site [chemical binding]; other site 632772007446 Gluconate-6-phosphate binding site [chemical binding]; other site 632772007447 Shikimate kinase; Region: SKI; pfam01202 632772007448 GntP family permease; Region: GntP_permease; pfam02447 632772007449 fructuronate transporter; Provisional; Region: PRK10034; cl15264 632772007450 Transcriptional regulators [Transcription]; Region: FadR; COG2186 632772007451 FCD domain; Region: FCD; pfam07729 632772007452 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 632772007453 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772007454 putative substrate translocation pore; other site 632772007455 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 632772007456 non-specific DNA interactions [nucleotide binding]; other site 632772007457 DNA binding site [nucleotide binding] 632772007458 sequence specific DNA binding site [nucleotide binding]; other site 632772007459 putative cAMP binding site [chemical binding]; other site 632772007460 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 632772007461 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 632772007462 nucleotide binding site [chemical binding]; other site 632772007463 Entner-Doudoroff aldolase; Region: eda; TIGR01182 632772007464 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 632772007465 active site 632772007466 intersubunit interface [polypeptide binding]; other site 632772007467 catalytic residue [active] 632772007468 phosphogluconate dehydratase; Validated; Region: PRK09054 632772007469 6-phosphogluconate dehydratase; Region: edd; TIGR01196 632772007470 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 632772007471 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 632772007472 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 632772007473 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 632772007474 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 632772007475 Muconolactone delta-isomerase; Region: MIase; pfam02426 632772007476 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 632772007477 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 632772007478 octamer interface [polypeptide binding]; other site 632772007479 active site 632772007480 catechol 1,2-dioxygenase, Actinobacterial; Region: catachol_actin; TIGR02438 632772007481 chlorocatechol 1,2-dioxygenases (1,2-CCDs) (type II enzymes) are homodimeric intradiol dioxygenases that degrade chlorocatechols via the addition of molecular oxygen and the subsequent cleavage between two adjacent hydroxyl groups. This reaction is part...; Region: 1,2-CCD; cd03462 632772007482 dimer interface [polypeptide binding]; other site 632772007483 active site 632772007484 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 632772007485 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 632772007486 Bacterial transcriptional regulator; Region: IclR; pfam01614 632772007487 Dioxygenase; Region: Dioxygenase_C; pfam00775 632772007488 active site 632772007489 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 632772007490 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 632772007491 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 632772007492 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 632772007493 Multicopper oxidase; Region: Cu-oxidase; pfam00394 632772007494 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 632772007495 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632772007496 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 632772007497 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632772007498 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 632772007499 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 632772007500 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 632772007501 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632772007502 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 632772007503 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632772007504 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 632772007505 Cytochrome P450; Region: p450; cl12078 632772007506 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 632772007507 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 632772007508 catalytic loop [active] 632772007509 iron binding site [ion binding]; other site 632772007510 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 632772007511 FAD binding pocket [chemical binding]; other site 632772007512 FAD binding motif [chemical binding]; other site 632772007513 phosphate binding motif [ion binding]; other site 632772007514 beta-alpha-beta structure motif; other site 632772007515 NAD binding pocket [chemical binding]; other site 632772007516 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 632772007517 Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542 632772007518 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 632772007519 putative alpha subunit interface [polypeptide binding]; other site 632772007520 putative active site [active] 632772007521 putative substrate binding site [chemical binding]; other site 632772007522 Fe binding site [ion binding]; other site 632772007523 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 632772007524 inter-subunit interface; other site 632772007525 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 632772007526 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 632772007527 catalytic loop [active] 632772007528 iron binding site [ion binding]; other site 632772007529 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 632772007530 FAD binding pocket [chemical binding]; other site 632772007531 FAD binding motif [chemical binding]; other site 632772007532 phosphate binding motif [ion binding]; other site 632772007533 beta-alpha-beta structure motif; other site 632772007534 NAD binding pocket [chemical binding]; other site 632772007535 Transcriptional regulators [Transcription]; Region: GntR; COG1802 632772007536 FCD domain; Region: FCD; pfam07729 632772007537 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 632772007538 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937 632772007539 putative NAD(P) binding site [chemical binding]; other site 632772007540 active site 632772007541 benzoate transport; Region: 2A0115; TIGR00895 632772007542 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772007543 putative substrate translocation pore; other site 632772007544 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772007545 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 632772007546 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 632772007547 TPP-binding site [chemical binding]; other site 632772007548 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 632772007549 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 632772007550 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 632772007551 dimer interface [polypeptide binding]; other site 632772007552 PYR/PP interface [polypeptide binding]; other site 632772007553 TPP binding site [chemical binding]; other site 632772007554 substrate binding site [chemical binding]; other site 632772007555 AAA ATPase domain; Region: AAA_16; pfam13191 632772007556 AAA domain; Region: AAA_22; pfam13401 632772007557 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632772007558 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632772007559 DNA binding residues [nucleotide binding] 632772007560 dimerization interface [polypeptide binding]; other site 632772007561 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 632772007562 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439 632772007563 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 632772007564 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 632772007565 Condensation domain; Region: Condensation; pfam00668 632772007566 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772007567 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 632772007568 acyl-activating enzyme (AAE) consensus motif; other site 632772007569 AMP binding site [chemical binding]; other site 632772007570 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772007571 Condensation domain; Region: Condensation; pfam00668 632772007572 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 632772007573 Condensation domain; Region: Condensation; pfam00668 632772007574 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 632772007575 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772007576 acyl-activating enzyme (AAE) consensus motif; other site 632772007577 AMP binding site [chemical binding]; other site 632772007578 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772007579 Condensation domain; Region: Condensation; pfam00668 632772007580 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 632772007581 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772007582 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772007583 acyl-activating enzyme (AAE) consensus motif; other site 632772007584 AMP binding site [chemical binding]; other site 632772007585 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772007586 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 632772007587 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772007588 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772007589 acyl-activating enzyme (AAE) consensus motif; other site 632772007590 AMP binding site [chemical binding]; other site 632772007591 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772007592 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 632772007593 aconitate hydratase; Validated; Region: PRK07229 632772007594 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 632772007595 substrate binding site [chemical binding]; other site 632772007596 ligand binding site [chemical binding]; other site 632772007597 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 632772007598 substrate binding site [chemical binding]; other site 632772007599 AAA ATPase domain; Region: AAA_16; pfam13191 632772007600 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 632772007601 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 632772007602 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632772007603 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 632772007604 DNA binding residues [nucleotide binding] 632772007605 VPS10 domain; Region: VPS10; smart00602 632772007606 Ubiquitin-like proteins; Region: UBQ; cl00155 632772007607 charged pocket; other site 632772007608 hydrophobic patch; other site 632772007609 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 632772007610 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 632772007611 Catalytic domain of Protein Kinases; Region: PKc; cd00180 632772007612 active site 632772007613 ATP binding site [chemical binding]; other site 632772007614 substrate binding site [chemical binding]; other site 632772007615 activation loop (A-loop); other site 632772007616 AAA ATPase domain; Region: AAA_16; pfam13191 632772007617 AAA domain; Region: AAA_22; pfam13401 632772007618 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 632772007619 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 632772007620 active site 632772007621 catalytic tetrad [active] 632772007622 choline dehydrogenase; Validated; Region: PRK02106 632772007623 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 632772007624 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 632772007625 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 632772007626 NAD(P) binding site [chemical binding]; other site 632772007627 catalytic residues [active] 632772007628 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 632772007629 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 632772007630 NAD binding site [chemical binding]; other site 632772007631 catalytic Zn binding site [ion binding]; other site 632772007632 substrate binding site [chemical binding]; other site 632772007633 structural Zn binding site [ion binding]; other site 632772007634 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components [Carbohydrate transport and metabolism]; Region: AraH; COG1172 632772007635 TM-ABC transporter signature motif; other site 632772007636 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 632772007637 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 632772007638 Walker A/P-loop; other site 632772007639 ATP binding site [chemical binding]; other site 632772007640 Q-loop/lid; other site 632772007641 ABC transporter signature motif; other site 632772007642 Walker B; other site 632772007643 D-loop; other site 632772007644 H-loop/switch region; other site 632772007645 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 632772007646 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 632772007647 TM-ABC transporter signature motif; other site 632772007648 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 632772007649 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 632772007650 ligand binding site [chemical binding]; other site 632772007651 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772007652 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772007653 active site 632772007654 Coenzyme A transferase; Region: CoA_trans; smart00882 632772007655 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 632772007656 Coenzyme A transferase; Region: CoA_trans; cl17247 632772007657 Transcriptional regulators [Transcription]; Region: PurR; COG1609 632772007658 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 632772007659 DNA binding site [nucleotide binding] 632772007660 domain linker motif; other site 632772007661 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 632772007662 ligand binding site [chemical binding]; other site 632772007663 dimerization interface [polypeptide binding]; other site 632772007664 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 632772007665 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 632772007666 putative NAD(P) binding site [chemical binding]; other site 632772007667 catalytic Zn binding site [ion binding]; other site 632772007668 structural Zn binding site [ion binding]; other site 632772007669 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 632772007670 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 632772007671 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 632772007672 metabolite-proton symporter; Region: 2A0106; TIGR00883 632772007673 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772007674 putative substrate translocation pore; other site 632772007675 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 632772007676 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 632772007677 Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454 632772007678 CGNR zinc finger; Region: zf-CGNR; pfam11706 632772007679 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 632772007680 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 632772007681 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 632772007682 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632772007683 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 632772007684 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 632772007685 active site 632772007686 dimer interface [polypeptide binding]; other site 632772007687 non-prolyl cis peptide bond; other site 632772007688 insertion regions; other site 632772007689 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772007690 metabolite-proton symporter; Region: 2A0106; TIGR00883 632772007691 putative substrate translocation pore; other site 632772007692 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772007693 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772007694 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 632772007695 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 632772007696 FAD binding domain; Region: FAD_binding_2; pfam00890 632772007697 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 632772007698 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 632772007699 active site 632772007700 dimer interface [polypeptide binding]; other site 632772007701 non-prolyl cis peptide bond; other site 632772007702 insertion regions; other site 632772007703 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 632772007704 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772007705 active site 632772007706 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 632772007707 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772007708 active site 632772007709 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 632772007710 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772007711 active site 632772007712 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 632772007713 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 632772007714 diiron binding motif [ion binding]; other site 632772007715 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 632772007716 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 632772007717 putative active site [active] 632772007718 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 632772007719 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772007720 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772007721 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 632772007722 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 632772007723 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 632772007724 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 632772007725 NAD(P) binding site [chemical binding]; other site 632772007726 active site 632772007727 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632772007728 dimerization interface [polypeptide binding]; other site 632772007729 putative DNA binding site [nucleotide binding]; other site 632772007730 putative Zn2+ binding site [ion binding]; other site 632772007731 Protein of unknown function DUF72; Region: DUF72; pfam01904 632772007732 GYD domain; Region: GYD; pfam08734 632772007733 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 632772007734 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 632772007735 ABC1 family; Region: ABC1; cl17513 632772007736 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 632772007737 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 632772007738 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 632772007739 putative metal binding site [ion binding]; other site 632772007740 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 632772007741 putative metal binding site [ion binding]; other site 632772007742 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 632772007743 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 632772007744 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 632772007745 putative metal binding site [ion binding]; other site 632772007746 Tellurium resistance protein; Region: Tellurium_res; pfam10138 632772007747 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 632772007748 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 632772007749 putative metal binding site [ion binding]; other site 632772007750 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 632772007751 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 632772007752 active site 632772007753 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 632772007754 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 632772007755 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 632772007756 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 632772007757 putative metal binding site [ion binding]; other site 632772007758 hypothetical protein; Provisional; Region: PRK14013 632772007759 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 632772007760 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 632772007761 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 632772007762 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 632772007763 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 632772007764 TrkA-N domain; Region: TrkA_N; pfam02254 632772007765 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 632772007766 homotrimer interaction site [polypeptide binding]; other site 632772007767 putative active site [active] 632772007768 Transcriptional regulator [Transcription]; Region: IclR; COG1414 632772007769 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 632772007770 Bacterial transcriptional regulator; Region: IclR; pfam01614 632772007771 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 632772007772 substrate binding site [chemical binding]; other site 632772007773 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 632772007774 ATP binding site [chemical binding]; other site 632772007775 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 632772007776 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 632772007777 dimer interface [polypeptide binding]; other site 632772007778 active site 632772007779 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 632772007780 substrate binding site [chemical binding]; other site 632772007781 catalytic residue [active] 632772007782 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 632772007783 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 632772007784 active site 632772007785 putative substrate binding pocket [chemical binding]; other site 632772007786 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 632772007787 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 632772007788 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 632772007789 active site 632772007790 intersubunit interface [polypeptide binding]; other site 632772007791 catalytic residue [active] 632772007792 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 632772007793 fructuronate transporter; Provisional; Region: PRK10034; cl15264 632772007794 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772007795 S-adenosylmethionine binding site [chemical binding]; other site 632772007796 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632772007797 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 632772007798 Walker A/P-loop; other site 632772007799 ATP binding site [chemical binding]; other site 632772007800 Q-loop/lid; other site 632772007801 ABC transporter signature motif; other site 632772007802 Walker B; other site 632772007803 D-loop; other site 632772007804 H-loop/switch region; other site 632772007805 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772007806 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 632772007807 DNA-binding interface [nucleotide binding]; DNA binding site 632772007808 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 632772007809 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 632772007810 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 632772007811 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 632772007812 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 632772007813 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 632772007814 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 632772007815 Bacterial transcriptional regulator; Region: IclR; pfam01614 632772007816 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 632772007817 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 632772007818 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 632772007819 shikimate binding site; other site 632772007820 NAD(P) binding site [chemical binding]; other site 632772007821 shikimate transporter; Provisional; Region: PRK09952 632772007822 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772007823 putative substrate translocation pore; other site 632772007824 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 632772007825 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 632772007826 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 632772007827 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 632772007828 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 632772007829 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 632772007830 Phosphoesterase family; Region: Phosphoesterase; pfam04185 632772007831 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 632772007832 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 632772007833 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 632772007834 classical (c) SDRs; Region: SDR_c; cd05233 632772007835 NAD(P) binding site [chemical binding]; other site 632772007836 active site 632772007837 SnoaL-like domain; Region: SnoaL_4; pfam13577 632772007838 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 632772007839 classical (c) SDRs; Region: SDR_c; cd05233 632772007840 NAD(P) binding site [chemical binding]; other site 632772007841 active site 632772007842 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 632772007843 classical (c) SDRs; Region: SDR_c; cd05233 632772007844 NAD(P) binding site [chemical binding]; other site 632772007845 active site 632772007846 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12835 632772007847 Predicted oxidoreductase [General function prediction only]; Region: COG3573 632772007848 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 632772007849 Predicted transcriptional regulators [Transcription]; Region: COG1695 632772007850 Transcriptional regulator PadR-like family; Region: PadR; cl17335 632772007851 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 632772007852 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 632772007853 Transcriptional regulator [Transcription]; Region: IclR; COG1414 632772007854 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 632772007855 Bacterial transcriptional regulator; Region: IclR; pfam01614 632772007856 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 632772007857 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 632772007858 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 632772007859 active site 632772007860 Fe binding site [ion binding]; other site 632772007861 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772007862 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772007863 active site 632772007864 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 632772007865 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 632772007866 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 632772007867 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 632772007868 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 632772007869 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 632772007870 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 632772007871 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 632772007872 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 632772007873 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 632772007874 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 632772007875 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 632772007876 NAD binding site [chemical binding]; other site 632772007877 catalytic Zn binding site [ion binding]; other site 632772007878 substrate binding site [chemical binding]; other site 632772007879 structural Zn binding site [ion binding]; other site 632772007880 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 632772007881 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 632772007882 NAD(P) binding site [chemical binding]; other site 632772007883 catalytic residues [active] 632772007884 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 632772007885 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632772007886 Walker A motif; other site 632772007887 ATP binding site [chemical binding]; other site 632772007888 Walker B motif; other site 632772007889 arginine finger; other site 632772007890 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 632772007891 Secretory lipase; Region: LIP; pfam03583 632772007892 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 632772007893 metabolite-proton symporter; Region: 2A0106; TIGR00883 632772007894 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772007895 putative substrate translocation pore; other site 632772007896 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 632772007897 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 632772007898 metal binding site [ion binding]; metal-binding site 632772007899 dimer interface [polypeptide binding]; other site 632772007900 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 632772007901 AsnC family; Region: AsnC_trans_reg; pfam01037 632772007902 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 632772007903 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 632772007904 AsnC family; Region: AsnC_trans_reg; pfam01037 632772007905 Protein of unknown function (DUF664); Region: DUF664; pfam04978 632772007906 DinB superfamily; Region: DinB_2; pfam12867 632772007907 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772007908 S-adenosylmethionine binding site [chemical binding]; other site 632772007909 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 632772007910 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 632772007911 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 632772007912 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 632772007913 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 632772007914 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 632772007915 Cytochrome P450; Region: p450; cl12078 632772007916 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 632772007917 active site 632772007918 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632772007919 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 632772007920 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632772007921 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 632772007922 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 632772007923 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 632772007924 catechol 1,2-dioxygenase, Actinobacterial; Region: catachol_actin; TIGR02438 632772007925 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 632772007926 active site 632772007927 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 632772007928 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 632772007929 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 632772007930 dimer interface [polypeptide binding]; other site 632772007931 active site 632772007932 acyl-CoA synthetase; Validated; Region: PRK06164 632772007933 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772007934 acyl-activating enzyme (AAE) consensus motif; other site 632772007935 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772007936 acyl-activating enzyme (AAE) consensus motif; other site 632772007937 AMP binding site [chemical binding]; other site 632772007938 active site 632772007939 CoA binding site [chemical binding]; other site 632772007940 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 632772007941 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 632772007942 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772007943 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772007944 active site 632772007945 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772007946 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772007947 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 632772007948 Protein of unknown function, DUF485; Region: DUF485; pfam04341 632772007949 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 632772007950 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 632772007951 Na binding site [ion binding]; other site 632772007952 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 632772007953 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 632772007954 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632772007955 motif II; other site 632772007956 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 632772007957 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 632772007958 Protein of unknown function (DUF2568); Region: DUF2568; pfam10823 632772007959 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 632772007960 Fatty acid desaturase; Region: FA_desaturase; pfam00487 632772007961 Di-iron ligands [ion binding]; other site 632772007962 Rubredoxin [Energy production and conversion]; Region: COG1773 632772007963 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 632772007964 iron binding site [ion binding]; other site 632772007965 Rubredoxin [Energy production and conversion]; Region: COG1773 632772007966 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 632772007967 iron binding site [ion binding]; other site 632772007968 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 632772007969 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 632772007970 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772007971 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772007972 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 632772007973 active site 632772007974 NTP binding site [chemical binding]; other site 632772007975 metal binding triad [ion binding]; metal-binding site 632772007976 antibiotic binding site [chemical binding]; other site 632772007977 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 632772007978 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 632772007979 Transcriptional regulator [Transcription]; Region: IclR; COG1414 632772007980 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 632772007981 Bacterial transcriptional regulator; Region: IclR; pfam01614 632772007982 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 632772007983 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772007984 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632772007985 putative substrate translocation pore; other site 632772007986 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 632772007987 dimer interface [polypeptide binding]; other site 632772007988 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 632772007989 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 632772007990 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 632772007991 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 632772007992 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 632772007993 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 632772007994 ABC-ATPase subunit interface; other site 632772007995 dimer interface [polypeptide binding]; other site 632772007996 putative PBP binding regions; other site 632772007997 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 632772007998 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 632772007999 intersubunit interface [polypeptide binding]; other site 632772008000 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 632772008001 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 632772008002 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772008003 NAD(P) binding site [chemical binding]; other site 632772008004 active site 632772008005 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 632772008006 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 632772008007 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 632772008008 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 632772008009 catalytic residue [active] 632772008010 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772008011 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772008012 active site 632772008013 Protein of unknown function (DUF419); Region: DUF419; pfam04237 632772008014 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 632772008015 putative hydrophobic ligand binding site [chemical binding]; other site 632772008016 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 632772008017 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 632772008018 putative NAD(P) binding site [chemical binding]; other site 632772008019 putative active site [active] 632772008020 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 632772008021 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 632772008022 putative NAD(P) binding site [chemical binding]; other site 632772008023 putative active site [active] 632772008024 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 632772008025 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 632772008026 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 632772008027 Fasciclin domain; Region: Fasciclin; pfam02469 632772008028 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 632772008029 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 632772008030 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 632772008031 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 632772008032 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 632772008033 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772008034 S-adenosylmethionine binding site [chemical binding]; other site 632772008035 SCP-2 sterol transfer family; Region: SCP2; cl01225 632772008036 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 632772008037 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772008038 S-adenosylmethionine binding site [chemical binding]; other site 632772008039 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 632772008040 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 632772008041 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632772008042 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 632772008043 DNA binding residues [nucleotide binding] 632772008044 Anti-sigma-K factor rskA; Region: RskA; pfam10099 632772008045 malate synthase G; Provisional; Region: PRK02999 632772008046 active site 632772008047 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 632772008048 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 632772008049 dimer interface [polypeptide binding]; other site 632772008050 TPP-binding site [chemical binding]; other site 632772008051 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 632772008052 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 632772008053 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 632772008054 Na binding site [ion binding]; other site 632772008055 putative substrate binding site [chemical binding]; other site 632772008056 allantoinase; Region: allantoinase; TIGR03178 632772008057 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 632772008058 active site 632772008059 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 632772008060 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 632772008061 Malic enzyme, N-terminal domain; Region: malic; pfam00390 632772008062 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 632772008063 putative NAD(P) binding site [chemical binding]; other site 632772008064 allantoicase; Provisional; Region: PRK13257 632772008065 Allantoicase repeat; Region: Allantoicase; pfam03561 632772008066 Allantoicase repeat; Region: Allantoicase; pfam03561 632772008067 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 632772008068 glyoxylate carboligase; Provisional; Region: PRK11269 632772008069 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 632772008070 PYR/PP interface [polypeptide binding]; other site 632772008071 dimer interface [polypeptide binding]; other site 632772008072 TPP binding site [chemical binding]; other site 632772008073 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 632772008074 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 632772008075 TPP-binding site [chemical binding]; other site 632772008076 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 632772008077 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 632772008078 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 632772008079 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 632772008080 putative active site pocket [active] 632772008081 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 632772008082 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 632772008083 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 632772008084 Transcriptional regulator [Transcription]; Region: IclR; COG1414 632772008085 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632772008086 putative DNA binding site [nucleotide binding]; other site 632772008087 putative Zn2+ binding site [ion binding]; other site 632772008088 Bacterial transcriptional regulator; Region: IclR; pfam01614 632772008089 Clp amino terminal domain; Region: Clp_N; pfam02861 632772008090 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632772008091 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632772008092 DNA binding residues [nucleotide binding] 632772008093 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 632772008094 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 632772008095 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 632772008096 putative molybdopterin cofactor binding site [chemical binding]; other site 632772008097 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 632772008098 putative molybdopterin cofactor binding site; other site 632772008099 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 632772008100 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 632772008101 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 632772008102 NAD binding site [chemical binding]; other site 632772008103 catalytic Zn binding site [ion binding]; other site 632772008104 substrate binding site [chemical binding]; other site 632772008105 structural Zn binding site [ion binding]; other site 632772008106 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 632772008107 active sites [active] 632772008108 tetramer interface [polypeptide binding]; other site 632772008109 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 632772008110 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 632772008111 Walker A/P-loop; other site 632772008112 ATP binding site [chemical binding]; other site 632772008113 Q-loop/lid; other site 632772008114 ABC transporter signature motif; other site 632772008115 Walker B; other site 632772008116 D-loop; other site 632772008117 H-loop/switch region; other site 632772008118 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772008119 dimer interface [polypeptide binding]; other site 632772008120 conserved gate region; other site 632772008121 ABC-ATPase subunit interface; other site 632772008122 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 632772008123 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 632772008124 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 632772008125 Beta-lactamase; Region: Beta-lactamase; pfam00144 632772008126 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 632772008127 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 632772008128 metal binding site [ion binding]; metal-binding site 632772008129 substrate binding pocket [chemical binding]; other site 632772008130 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 632772008131 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 632772008132 NADP binding site [chemical binding]; other site 632772008133 dimer interface [polypeptide binding]; other site 632772008134 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 632772008135 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 632772008136 Transcriptional regulators [Transcription]; Region: GntR; COG1802 632772008137 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772008138 DNA-binding site [nucleotide binding]; DNA binding site 632772008139 FCD domain; Region: FCD; pfam07729 632772008140 Condensation domain; Region: Condensation; pfam00668 632772008141 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 632772008142 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772008143 acyl-activating enzyme (AAE) consensus motif; other site 632772008144 AMP binding site [chemical binding]; other site 632772008145 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772008146 Condensation domain; Region: Condensation; pfam00668 632772008147 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 632772008148 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 632772008149 Condensation domain; Region: Condensation; pfam00668 632772008150 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 632772008151 Nonribosomal peptide synthase; Region: NRPS; pfam08415 632772008152 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 632772008153 acyl-activating enzyme (AAE) consensus motif; other site 632772008154 AMP binding site [chemical binding]; other site 632772008155 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772008156 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 632772008157 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 632772008158 intersubunit interface [polypeptide binding]; other site 632772008159 Condensation domain; Region: Condensation; pfam00668 632772008160 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 632772008161 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772008162 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772008163 acyl-activating enzyme (AAE) consensus motif; other site 632772008164 AMP binding site [chemical binding]; other site 632772008165 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772008166 Condensation domain; Region: Condensation; pfam00668 632772008167 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 632772008168 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772008169 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772008170 acyl-activating enzyme (AAE) consensus motif; other site 632772008171 AMP binding site [chemical binding]; other site 632772008172 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772008173 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 632772008174 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 632772008175 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 632772008176 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 632772008177 acyl-activating enzyme (AAE) consensus motif; other site 632772008178 active site 632772008179 AMP binding site [chemical binding]; other site 632772008180 substrate binding site [chemical binding]; other site 632772008181 salicylate synthase MbtI; Reviewed; Region: PRK07912 632772008182 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 632772008183 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 632772008184 NAD(P) binding site [chemical binding]; other site 632772008185 catalytic residues [active] 632772008186 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 632772008187 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 632772008188 tyramine oxidase; Provisional; Region: tynA; PRK11504 632772008189 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 632772008190 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 632772008191 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 632772008192 Amino acid permease; Region: AA_permease_2; pfam13520 632772008193 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 632772008194 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 632772008195 NAD(P) binding site [chemical binding]; other site 632772008196 catalytic residues [active] 632772008197 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 632772008198 Transcriptional regulator [Transcription]; Region: IclR; COG1414 632772008199 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 632772008200 Bacterial transcriptional regulator; Region: IclR; pfam01614 632772008201 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 632772008202 active site 632772008203 catalytic triad [active] 632772008204 oxyanion hole [active] 632772008205 Transcription factor WhiB; Region: Whib; pfam02467 632772008206 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 632772008207 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 632772008208 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 632772008209 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 632772008210 Magnetospirillum NAD(P)+-dependent aldehyde dehydrogenase MSR-1-like; Region: ALDH_MGR_2402; cd07108 632772008211 NAD(P) binding site [chemical binding]; other site 632772008212 catalytic residues [active] 632772008213 catalytic residues [active] 632772008214 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 632772008215 Spore germination protein; Region: Spore_permease; cl17796 632772008216 Glycine/serine hydroxymethyltransferase [Amino acid transport and metabolism]; Region: GlyA; COG0112 632772008217 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 632772008218 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 632772008219 catalytic residue [active] 632772008220 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 632772008221 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 632772008222 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 632772008223 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 632772008224 Transcription factor WhiB; Region: Whib; pfam02467 632772008225 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 632772008226 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 632772008227 active site 632772008228 catalytic residues [active] 632772008229 DNA binding site [nucleotide binding] 632772008230 Int/Topo IB signature motif; other site 632772008231 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 632772008232 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 632772008233 active site 632772008234 catalytic residues [active] 632772008235 DNA binding site [nucleotide binding] 632772008236 Int/Topo IB signature motif; other site 632772008237 multiple promoter invertase; Provisional; Region: mpi; PRK13413 632772008238 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 632772008239 catalytic residues [active] 632772008240 catalytic nucleophile [active] 632772008241 Presynaptic Site I dimer interface [polypeptide binding]; other site 632772008242 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 632772008243 Synaptic Flat tetramer interface [polypeptide binding]; other site 632772008244 Synaptic Site I dimer interface [polypeptide binding]; other site 632772008245 DNA binding site [nucleotide binding] 632772008246 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 632772008247 DNA-binding interface [nucleotide binding]; DNA binding site 632772008248 potential frameshift: common BLAST hit: gi|111025328|ref|YP_707748.1| methyltransferase 632772008249 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772008250 S-adenosylmethionine binding site [chemical binding]; other site 632772008251 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 632772008252 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 632772008253 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772008254 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772008255 Uncharacterized conserved protein [Function unknown]; Region: COG5361 632772008256 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 632772008257 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 632772008258 active site 2 [active] 632772008259 active site 1 [active] 632772008260 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 632772008261 CoA-transferase family III; Region: CoA_transf_3; pfam02515 632772008262 enoyl-CoA hydratase; Provisional; Region: PRK08290 632772008263 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772008264 substrate binding site [chemical binding]; other site 632772008265 oxyanion hole (OAH) forming residues; other site 632772008266 trimer interface [polypeptide binding]; other site 632772008267 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 632772008268 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772008269 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772008270 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 632772008271 acyl-activating enzyme (AAE) consensus motif; other site 632772008272 acyl-activating enzyme (AAE) consensus motif; other site 632772008273 putative AMP binding site [chemical binding]; other site 632772008274 putative active site [active] 632772008275 putative CoA binding site [chemical binding]; other site 632772008276 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 632772008277 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772008278 substrate binding site [chemical binding]; other site 632772008279 oxyanion hole (OAH) forming residues; other site 632772008280 trimer interface [polypeptide binding]; other site 632772008281 long-chain-fatty-acid--CoA ligase; Provisional; Region: PRK12406 632772008282 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772008283 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 632772008284 acyl-activating enzyme (AAE) consensus motif; other site 632772008285 acyl-activating enzyme (AAE) consensus motif; other site 632772008286 putative AMP binding site [chemical binding]; other site 632772008287 putative active site [active] 632772008288 putative CoA binding site [chemical binding]; other site 632772008289 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772008290 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772008291 active site 632772008292 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 632772008293 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772008294 NAD(P) binding site [chemical binding]; other site 632772008295 active site 632772008296 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 632772008297 active site 2 [active] 632772008298 active site 1 [active] 632772008299 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 632772008300 active site 632772008301 catalytic site [active] 632772008302 lipid-transfer protein; Provisional; Region: PRK08256 632772008303 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 632772008304 active site 632772008305 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772008306 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772008307 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772008308 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772008309 Protein of unknown function (DUF808); Region: DUF808; cl01002 632772008310 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 632772008311 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 632772008312 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632772008313 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632772008314 active site 632772008315 phosphorylation site [posttranslational modification] 632772008316 intermolecular recognition site; other site 632772008317 dimerization interface [polypeptide binding]; other site 632772008318 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632772008319 DNA binding residues [nucleotide binding] 632772008320 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632772008321 Response regulator receiver domain; Region: Response_reg; pfam00072 632772008322 active site 632772008323 phosphorylation site [posttranslational modification] 632772008324 intermolecular recognition site; other site 632772008325 dimerization interface [polypeptide binding]; other site 632772008326 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 632772008327 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 632772008328 Histidine kinase; Region: HisKA_3; pfam07730 632772008329 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632772008330 ATP binding site [chemical binding]; other site 632772008331 Mg2+ binding site [ion binding]; other site 632772008332 G-X-G motif; other site 632772008333 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772008334 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772008335 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772008336 active site 632772008337 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772008338 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772008339 active site 632772008340 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772008341 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 632772008342 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772008343 AMP binding site [chemical binding]; other site 632772008344 active site 632772008345 acyl-activating enzyme (AAE) consensus motif; other site 632772008346 acyl-activating enzyme (AAE) consensus motif; other site 632772008347 CoA binding site [chemical binding]; other site 632772008348 2-hydroxycyclohexanecarboxyl-CoA dehydrogenase; Region: benzo_BadH; TIGR03206 632772008349 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772008350 NAD(P) binding site [chemical binding]; other site 632772008351 active site 632772008352 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772008353 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 632772008354 substrate binding site [chemical binding]; other site 632772008355 oxyanion hole (OAH) forming residues; other site 632772008356 trimer interface [polypeptide binding]; other site 632772008357 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772008358 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772008359 active site 632772008360 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772008361 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772008362 Transcriptional regulators [Transcription]; Region: PurR; COG1609 632772008363 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 632772008364 DNA binding site [nucleotide binding] 632772008365 domain linker motif; other site 632772008366 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 632772008367 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 632772008368 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 632772008369 inhibitor site; inhibition site 632772008370 active site 632772008371 dimer interface [polypeptide binding]; other site 632772008372 catalytic residue [active] 632772008373 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 632772008374 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 632772008375 YCII-related domain; Region: YCII; cl00999 632772008376 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 632772008377 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772008378 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772008379 Domain of unknown function (DUF385); Region: DUF385; cl04387 632772008380 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772008381 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 632772008382 Cytochrome P450; Region: p450; cl12078 632772008383 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772008384 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772008385 acyl-CoA synthetase; Validated; Region: PRK06178 632772008386 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772008387 acyl-activating enzyme (AAE) consensus motif; other site 632772008388 AMP binding site [chemical binding]; other site 632772008389 active site 632772008390 CoA binding site [chemical binding]; other site 632772008391 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 632772008392 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 632772008393 ATP-grasp domain; Region: ATP-grasp_4; cl17255 632772008394 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 632772008395 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 632772008396 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 632772008397 carboxyltransferase (CT) interaction site; other site 632772008398 biotinylation site [posttranslational modification]; other site 632772008399 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 632772008400 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 632772008401 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 632772008402 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 632772008403 NADP binding site [chemical binding]; other site 632772008404 dimer interface [polypeptide binding]; other site 632772008405 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 632772008406 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 632772008407 putative NAD(P) binding site [chemical binding]; other site 632772008408 catalytic Zn binding site [ion binding]; other site 632772008409 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 632772008410 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 632772008411 substrate binding site [chemical binding]; other site 632772008412 ATP binding site [chemical binding]; other site 632772008413 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 632772008414 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 632772008415 active site 632772008416 intersubunit interface [polypeptide binding]; other site 632772008417 catalytic residue [active] 632772008418 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772008419 metabolite-proton symporter; Region: 2A0106; TIGR00883 632772008420 putative substrate translocation pore; other site 632772008421 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 632772008422 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 632772008423 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 632772008424 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 632772008425 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 632772008426 metal binding site [ion binding]; metal-binding site 632772008427 substrate binding pocket [chemical binding]; other site 632772008428 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_6; cd12165 632772008429 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 632772008430 putative ligand binding site [chemical binding]; other site 632772008431 NAD binding site [chemical binding]; other site 632772008432 dimer interface [polypeptide binding]; other site 632772008433 putative catalytic site [active] 632772008434 Transcriptional regulators [Transcription]; Region: PurR; COG1609 632772008435 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 632772008436 DNA binding site [nucleotide binding] 632772008437 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 632772008438 ligand binding site [chemical binding]; other site 632772008439 dimerization interface [polypeptide binding]; other site 632772008440 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 632772008441 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 632772008442 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 632772008443 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575 632772008444 active site 632772008445 dimer interface [polypeptide binding]; other site 632772008446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772008447 putative substrate translocation pore; other site 632772008448 MarR family; Region: MarR_2; pfam12802 632772008449 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 632772008450 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 632772008451 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 632772008452 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 632772008453 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 632772008454 FAD binding domain; Region: FAD_binding_4; pfam01565 632772008455 aromatic amino acid exporter; Provisional; Region: PRK11689 632772008456 EamA-like transporter family; Region: EamA; pfam00892 632772008457 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 632772008458 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772008459 putative substrate translocation pore; other site 632772008460 Transcriptional regulators [Transcription]; Region: GntR; COG1802 632772008461 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772008462 DNA-binding site [nucleotide binding]; DNA binding site 632772008463 FCD domain; Region: FCD; pfam07729 632772008464 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 632772008465 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 632772008466 NAD(P) binding site [chemical binding]; other site 632772008467 catalytic residues [active] 632772008468 Transcriptional regulators [Transcription]; Region: GntR; COG1802 632772008469 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772008470 DNA-binding site [nucleotide binding]; DNA binding site 632772008471 FCD domain; Region: FCD; pfam07729 632772008472 Transcription factor WhiB; Region: Whib; pfam02467 632772008473 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 632772008474 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 632772008475 MarR family; Region: MarR; pfam01047 632772008476 Predicted ATPase [General function prediction only]; Region: COG3903 632772008477 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632772008478 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632772008479 DNA binding residues [nucleotide binding] 632772008480 dimerization interface [polypeptide binding]; other site 632772008481 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 632772008482 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772008483 DNA-binding site [nucleotide binding]; DNA binding site 632772008484 UTRA domain; Region: UTRA; cl17743 632772008485 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 632772008486 substrate binding pocket [chemical binding]; other site 632772008487 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 632772008488 membrane-bound complex binding site; other site 632772008489 hinge residues; other site 632772008490 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 632772008491 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 632772008492 Walker A/P-loop; other site 632772008493 ATP binding site [chemical binding]; other site 632772008494 Q-loop/lid; other site 632772008495 ABC transporter signature motif; other site 632772008496 Walker B; other site 632772008497 D-loop; other site 632772008498 H-loop/switch region; other site 632772008499 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 632772008500 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772008501 dimer interface [polypeptide binding]; other site 632772008502 conserved gate region; other site 632772008503 putative PBP binding loops; other site 632772008504 ABC-ATPase subunit interface; other site 632772008505 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 632772008506 Tyrosine phosphatase family; Region: Y_phosphatase2; pfam03162 632772008507 phosphoenolpyruvate synthase; Validated; Region: PRK06241 632772008508 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 632772008509 Phosphotransferase enzyme family; Region: APH; pfam01636 632772008510 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 632772008511 active site 632772008512 substrate binding site [chemical binding]; other site 632772008513 ATP binding site [chemical binding]; other site 632772008514 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 632772008515 classical (c) SDRs; Region: SDR_c; cd05233 632772008516 NAD(P) binding site [chemical binding]; other site 632772008517 active site 632772008518 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 632772008519 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 632772008520 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 632772008521 SnoaL-like domain; Region: SnoaL_4; pfam13577 632772008522 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 632772008523 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 632772008524 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 632772008525 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 632772008526 FMN-binding pocket [chemical binding]; other site 632772008527 flavin binding motif; other site 632772008528 phosphate binding motif [ion binding]; other site 632772008529 beta-alpha-beta structure motif; other site 632772008530 NAD binding pocket [chemical binding]; other site 632772008531 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 632772008532 catalytic loop [active] 632772008533 iron binding site [ion binding]; other site 632772008534 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 632772008535 Cytochrome P450; Region: p450; cl12078 632772008536 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 632772008537 potential frameshift: common BLAST hit: gi|126436600|ref|YP_001072291.1| PEP-utilising enzyme, mobile region 632772008538 phosphoenolpyruvate synthase; Validated; Region: PRK06241 632772008539 hypothetical protein; Provisional; Region: PRK08296 632772008540 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 632772008541 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772008542 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 632772008543 putative AMP binding site [chemical binding]; other site 632772008544 putative active site [active] 632772008545 acyl-activating enzyme (AAE) consensus motif; other site 632772008546 putative CoA binding site [chemical binding]; other site 632772008547 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772008548 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 632772008549 NAD(P) binding site [chemical binding]; other site 632772008550 active site 632772008551 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 632772008552 active site 1 [active] 632772008553 active site 2 [active] 632772008554 pyruvate phosphate dikinase; Provisional; Region: PRK05878 632772008555 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 632772008556 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 632772008557 MarR family; Region: MarR_2; cl17246 632772008558 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 632772008559 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 632772008560 SnoaL-like domain; Region: SnoaL_4; pfam13577 632772008561 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 632772008562 catalytic core [active] 632772008563 MarR family; Region: MarR; pfam01047 632772008564 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 632772008565 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 632772008566 FMN binding site [chemical binding]; other site 632772008567 substrate binding site [chemical binding]; other site 632772008568 putative catalytic residue [active] 632772008569 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 632772008570 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 632772008571 dimer interaction site [polypeptide binding]; other site 632772008572 substrate-binding tunnel; other site 632772008573 active site 632772008574 catalytic site [active] 632772008575 substrate binding site [chemical binding]; other site 632772008576 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 632772008577 CoA-transferase family III; Region: CoA_transf_3; pfam02515 632772008578 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 632772008579 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 632772008580 dimer interface [polypeptide binding]; other site 632772008581 active site 632772008582 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 632772008583 Predicted integral membrane metal-binding protein (DUF2296); Region: DUF2296; pfam10058 632772008584 DUF35 OB-fold domain; Region: DUF35; pfam01796 632772008585 lipid-transfer protein; Provisional; Region: PRK08256 632772008586 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 632772008587 active site 632772008588 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772008589 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772008590 active site 632772008591 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772008592 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772008593 active site 632772008594 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 632772008595 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 632772008596 active site 632772008597 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 632772008598 catalytic triad [active] 632772008599 dimer interface [polypeptide binding]; other site 632772008600 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 632772008601 catalytic core [active] 632772008602 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 632772008603 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 632772008604 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 632772008605 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 632772008606 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 632772008607 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 632772008608 classical (c) SDRs; Region: SDR_c; cd05233 632772008609 NAD(P) binding site [chemical binding]; other site 632772008610 active site 632772008611 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 632772008612 active site 632772008613 ATP binding site [chemical binding]; other site 632772008614 Phosphotransferase enzyme family; Region: APH; pfam01636 632772008615 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 632772008616 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl01634 632772008617 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 632772008618 enoyl-CoA hydratase; Provisional; Region: PRK06688 632772008619 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772008620 substrate binding site [chemical binding]; other site 632772008621 oxyanion hole (OAH) forming residues; other site 632772008622 trimer interface [polypeptide binding]; other site 632772008623 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772008624 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772008625 active site 632772008626 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 632772008627 active site 632772008628 catalytic site [active] 632772008629 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 632772008630 active site 2 [active] 632772008631 active site 1 [active] 632772008632 short chain dehydrogenase; Provisional; Region: PRK07791 632772008633 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772008634 NAD(P) binding site [chemical binding]; other site 632772008635 active site 632772008636 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772008637 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772008638 active site 632772008639 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 632772008640 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 632772008641 alpha subunit interface [polypeptide binding]; other site 632772008642 TPP binding site [chemical binding]; other site 632772008643 heterodimer interface [polypeptide binding]; other site 632772008644 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 632772008645 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 632772008646 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 632772008647 tetramer interface [polypeptide binding]; other site 632772008648 TPP-binding site [chemical binding]; other site 632772008649 heterodimer interface [polypeptide binding]; other site 632772008650 phosphorylation loop region [posttranslational modification] 632772008651 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 632772008652 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 632772008653 [2Fe-2S] cluster binding site [ion binding]; other site 632772008654 C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882 632772008655 putative alpha subunit interface [polypeptide binding]; other site 632772008656 putative active site [active] 632772008657 putative substrate binding site [chemical binding]; other site 632772008658 Fe binding site [ion binding]; other site 632772008659 MarR family; Region: MarR; pfam01047 632772008660 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772008661 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 632772008662 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 632772008663 acyl-activating enzyme (AAE) consensus motif; other site 632772008664 acyl-activating enzyme (AAE) consensus motif; other site 632772008665 putative AMP binding site [chemical binding]; other site 632772008666 putative active site [active] 632772008667 putative CoA binding site [chemical binding]; other site 632772008668 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 632772008669 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772008670 substrate binding site [chemical binding]; other site 632772008671 oxyanion hole (OAH) forming residues; other site 632772008672 trimer interface [polypeptide binding]; other site 632772008673 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 632772008674 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772008675 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772008676 acyl-activating enzyme (AAE) consensus motif; other site 632772008677 acyl-activating enzyme (AAE) consensus motif; other site 632772008678 AMP binding site [chemical binding]; other site 632772008679 active site 632772008680 CoA binding site [chemical binding]; other site 632772008681 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 632772008682 putative active site [active] 632772008683 putative substrate binding site [chemical binding]; other site 632772008684 ATP binding site [chemical binding]; other site 632772008685 Phosphotransferase enzyme family; Region: APH; pfam01636 632772008686 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 632772008687 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 632772008688 acyl-activating enzyme (AAE) consensus motif; other site 632772008689 putative AMP binding site [chemical binding]; other site 632772008690 putative active site [active] 632772008691 putative CoA binding site [chemical binding]; other site 632772008692 SnoaL-like domain; Region: SnoaL_2; pfam12680 632772008693 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 632772008694 Predicted oxidoreductase [General function prediction only]; Region: COG3573 632772008695 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 632772008696 catalytic core [active] 632772008697 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 632772008698 SnoaL-like domain; Region: SnoaL_4; pfam13577 632772008699 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 632772008700 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632772008701 Walker A/P-loop; other site 632772008702 ATP binding site [chemical binding]; other site 632772008703 Q-loop/lid; other site 632772008704 ABC transporter signature motif; other site 632772008705 Walker B; other site 632772008706 D-loop; other site 632772008707 H-loop/switch region; other site 632772008708 TOBE domain; Region: TOBE_2; pfam08402 632772008709 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 632772008710 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772008711 dimer interface [polypeptide binding]; other site 632772008712 conserved gate region; other site 632772008713 putative PBP binding loops; other site 632772008714 ABC-ATPase subunit interface; other site 632772008715 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772008716 dimer interface [polypeptide binding]; other site 632772008717 conserved gate region; other site 632772008718 putative PBP binding loops; other site 632772008719 ABC-ATPase subunit interface; other site 632772008720 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 632772008721 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 632772008722 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 632772008723 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 632772008724 DNA binding residues [nucleotide binding] 632772008725 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 632772008726 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 632772008727 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 632772008728 inhibitor binding site; inhibition site 632772008729 catalytic Zn binding site [ion binding]; other site 632772008730 structural Zn binding site [ion binding]; other site 632772008731 NADP binding site [chemical binding]; other site 632772008732 tetramer interface [polypeptide binding]; other site 632772008733 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 632772008734 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 632772008735 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 632772008736 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 632772008737 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 632772008738 putative substrate binding site [chemical binding]; other site 632772008739 putative ATP binding site [chemical binding]; other site 632772008740 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 632772008741 D-xylulose kinase; Region: XylB; TIGR01312 632772008742 nucleotide binding site [chemical binding]; other site 632772008743 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 632772008744 Prostaglandin dehydrogenases; Region: PGDH; cd05288 632772008745 NAD(P) binding site [chemical binding]; other site 632772008746 substrate binding site [chemical binding]; other site 632772008747 dimer interface [polypeptide binding]; other site 632772008748 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 632772008749 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772008750 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772008751 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 632772008752 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 632772008753 acyl-activating enzyme (AAE) consensus motif; other site 632772008754 putative AMP binding site [chemical binding]; other site 632772008755 putative active site [active] 632772008756 putative CoA binding site [chemical binding]; other site 632772008757 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 632772008758 mce related protein; Region: MCE; pfam02470 632772008759 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 632772008760 mce related protein; Region: MCE; pfam02470 632772008761 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 632772008762 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 632772008763 mce related protein; Region: MCE; pfam02470 632772008764 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 632772008765 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 632772008766 mce related protein; Region: MCE; pfam02470 632772008767 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 632772008768 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 632772008769 mce related protein; Region: MCE; pfam02470 632772008770 mce related protein; Region: MCE; pfam02470 632772008771 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 632772008772 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 632772008773 Permease; Region: Permease; pfam02405 632772008774 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 632772008775 Permease; Region: Permease; pfam02405 632772008776 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 632772008777 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 632772008778 NAD(P) binding site [chemical binding]; other site 632772008779 catalytic residues [active] 632772008780 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 632772008781 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 632772008782 Ecdysteroid kinase; Region: EcKinase; cl17738 632772008783 Phosphotransferase enzyme family; Region: APH; pfam01636 632772008784 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772008785 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772008786 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772008787 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772008788 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 632772008789 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 632772008790 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 632772008791 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772008792 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 632772008793 substrate binding site [chemical binding]; other site 632772008794 oxyanion hole (OAH) forming residues; other site 632772008795 trimer interface [polypeptide binding]; other site 632772008796 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 632772008797 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 632772008798 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 632772008799 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 632772008800 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 632772008801 dimer interface [polypeptide binding]; other site 632772008802 active site 632772008803 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 632772008804 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 632772008805 Walker A/P-loop; other site 632772008806 ATP binding site [chemical binding]; other site 632772008807 Q-loop/lid; other site 632772008808 ABC transporter signature motif; other site 632772008809 Walker B; other site 632772008810 D-loop; other site 632772008811 H-loop/switch region; other site 632772008812 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 632772008813 N-acetyl-D-glucosamine binding site [chemical binding]; other site 632772008814 catalytic residue [active] 632772008815 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 632772008816 NlpC/P60 family; Region: NLPC_P60; pfam00877 632772008817 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 632772008818 putative FMN binding site [chemical binding]; other site 632772008819 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 632772008820 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 632772008821 CoA-transferase family III; Region: CoA_transf_3; pfam02515 632772008822 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772008823 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772008824 active site 632772008825 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772008826 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772008827 active site 632772008828 allantoate amidohydrolase; Reviewed; Region: PRK09290 632772008829 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 632772008830 active site 632772008831 metal binding site [ion binding]; metal-binding site 632772008832 dimer interface [polypeptide binding]; other site 632772008833 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 632772008834 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 632772008835 active site 632772008836 FMN binding site [chemical binding]; other site 632772008837 substrate binding site [chemical binding]; other site 632772008838 3Fe-4S cluster binding site [ion binding]; other site 632772008839 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 632772008840 domain_subunit interface; other site 632772008841 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 632772008842 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 632772008843 active site 632772008844 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 632772008845 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 632772008846 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 632772008847 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 632772008848 hydroxyglutarate oxidase; Provisional; Region: PRK11728 632772008849 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 632772008850 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 632772008851 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 632772008852 FMN-binding pocket [chemical binding]; other site 632772008853 flavin binding motif; other site 632772008854 phosphate binding motif [ion binding]; other site 632772008855 beta-alpha-beta structure motif; other site 632772008856 NAD binding pocket [chemical binding]; other site 632772008857 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 632772008858 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 632772008859 catalytic loop [active] 632772008860 iron binding site [ion binding]; other site 632772008861 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 632772008862 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772008863 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772008864 HutD; Region: HutD; pfam05962 632772008865 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 632772008866 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 632772008867 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 632772008868 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 632772008869 non-specific DNA binding site [nucleotide binding]; other site 632772008870 salt bridge; other site 632772008871 sequence-specific DNA binding site [nucleotide binding]; other site 632772008872 Cupin domain; Region: Cupin_2; cl17218 632772008873 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 632772008874 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 632772008875 NAD(P) binding site [chemical binding]; other site 632772008876 catalytic residues [active] 632772008877 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 632772008878 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 632772008879 NAD binding site [chemical binding]; other site 632772008880 catalytic Zn binding site [ion binding]; other site 632772008881 substrate binding site [chemical binding]; other site 632772008882 structural Zn binding site [ion binding]; other site 632772008883 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772008884 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772008885 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 632772008886 tyramine oxidase; Provisional; Region: tynA; PRK11504 632772008887 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 632772008888 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 632772008889 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 632772008890 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 632772008891 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 632772008892 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 632772008893 active site 632772008894 PAS domain; Region: PAS_9; pfam13426 632772008895 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 632772008896 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 632772008897 putative active site [active] 632772008898 heme pocket [chemical binding]; other site 632772008899 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632772008900 ATP binding site [chemical binding]; other site 632772008901 Mg2+ binding site [ion binding]; other site 632772008902 G-X-G motif; other site 632772008903 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772008904 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772008905 active site 632772008906 SnoaL-like domain; Region: SnoaL_4; pfam13577 632772008907 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 632772008908 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 632772008909 [2Fe-2S] cluster binding site [ion binding]; other site 632772008910 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 632772008911 putative alpha subunit interface [polypeptide binding]; other site 632772008912 putative active site [active] 632772008913 putative substrate binding site [chemical binding]; other site 632772008914 Fe binding site [ion binding]; other site 632772008915 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 632772008916 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 632772008917 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772008918 NAD(P) binding site [chemical binding]; other site 632772008919 active site 632772008920 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 632772008921 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 632772008922 FMN-binding pocket [chemical binding]; other site 632772008923 flavin binding motif; other site 632772008924 phosphate binding motif [ion binding]; other site 632772008925 beta-alpha-beta structure motif; other site 632772008926 NAD binding pocket [chemical binding]; other site 632772008927 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 632772008928 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 632772008929 catalytic loop [active] 632772008930 iron binding site [ion binding]; other site 632772008931 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 632772008932 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632772008933 active site 632772008934 phosphorylation site [posttranslational modification] 632772008935 intermolecular recognition site; other site 632772008936 dimerization interface [polypeptide binding]; other site 632772008937 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632772008938 DNA binding residues [nucleotide binding] 632772008939 dimerization interface [polypeptide binding]; other site 632772008940 Flavin Reductases; Region: FlaRed; cl00801 632772008941 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 632772008942 Na binding site [ion binding]; other site 632772008943 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 632772008944 Amidase; Region: Amidase; cl11426 632772008945 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 632772008946 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632772008947 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772008948 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 632772008949 acyl-activating enzyme (AAE) consensus motif; other site 632772008950 AMP binding site [chemical binding]; other site 632772008951 active site 632772008952 CoA binding site [chemical binding]; other site 632772008953 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 632772008954 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 632772008955 FAD binding pocket [chemical binding]; other site 632772008956 FAD binding motif [chemical binding]; other site 632772008957 phosphate binding motif [ion binding]; other site 632772008958 beta-alpha-beta structure motif; other site 632772008959 NAD(p) ribose binding residues [chemical binding]; other site 632772008960 NAD binding pocket [chemical binding]; other site 632772008961 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 632772008962 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 632772008963 catalytic loop [active] 632772008964 iron binding site [ion binding]; other site 632772008965 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 632772008966 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 632772008967 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 632772008968 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 632772008969 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 632772008970 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 632772008971 enoyl-CoA hydratase; Provisional; Region: PRK08140 632772008972 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772008973 substrate binding site [chemical binding]; other site 632772008974 oxyanion hole (OAH) forming residues; other site 632772008975 trimer interface [polypeptide binding]; other site 632772008976 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 632772008977 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 632772008978 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 632772008979 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 632772008980 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772008981 substrate binding site [chemical binding]; other site 632772008982 oxyanion hole (OAH) forming residues; other site 632772008983 trimer interface [polypeptide binding]; other site 632772008984 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 632772008985 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 632772008986 dimer interface [polypeptide binding]; other site 632772008987 active site 632772008988 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 632772008989 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 632772008990 substrate binding site [chemical binding]; other site 632772008991 dimer interface [polypeptide binding]; other site 632772008992 NADP binding site [chemical binding]; other site 632772008993 catalytic residues [active] 632772008994 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 632772008995 active site 2 [active] 632772008996 active site 1 [active] 632772008997 conserved hypothetical protein; Region: TIGR02118 632772008998 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 632772008999 CoenzymeA binding site [chemical binding]; other site 632772009000 subunit interaction site [polypeptide binding]; other site 632772009001 PHB binding site; other site 632772009002 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 632772009003 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 632772009004 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 632772009005 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 632772009006 Part of AAA domain; Region: AAA_19; pfam13245 632772009007 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 632772009008 AAA domain; Region: AAA_12; pfam13087 632772009009 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 632772009010 putative active site [active] 632772009011 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 632772009012 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772009013 DNA-binding site [nucleotide binding]; DNA binding site 632772009014 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 632772009015 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772009016 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772009017 active site 632772009018 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 632772009019 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 632772009020 putative active site [active] 632772009021 putative catalytic site [active] 632772009022 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 632772009023 active site 2 [active] 632772009024 active site 1 [active] 632772009025 mesaconyl-CoA isomerase; Region: mesacon_CoA_iso; TIGR04253 632772009026 CoA-transferase family III; Region: CoA_transf_3; pfam02515 632772009027 Cation efflux family; Region: Cation_efflux; cl00316 632772009028 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632772009029 putative DNA binding site [nucleotide binding]; other site 632772009030 putative Zn2+ binding site [ion binding]; other site 632772009031 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 632772009032 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 632772009033 putative heme binding pocket [chemical binding]; other site 632772009034 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 632772009035 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 632772009036 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 632772009037 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632772009038 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 632772009039 DNA binding residues [nucleotide binding] 632772009040 Putative zinc-finger; Region: zf-HC2; pfam13490 632772009041 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 632772009042 CoA-transferase family III; Region: CoA_transf_3; pfam02515 632772009043 Transcriptional regulator [Transcription]; Region: LysR; COG0583 632772009044 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 632772009045 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 632772009046 dimerization interface [polypeptide binding]; other site 632772009047 Transcriptional regulator [Transcription]; Region: LysR; COG0583 632772009048 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 632772009049 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 632772009050 dimerization interface [polypeptide binding]; other site 632772009051 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772009052 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 632772009053 substrate binding site [chemical binding]; other site 632772009054 oxyanion hole (OAH) forming residues; other site 632772009055 trimer interface [polypeptide binding]; other site 632772009056 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 632772009057 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 632772009058 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 632772009059 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772009060 D-galactonate transporter; Region: 2A0114; TIGR00893 632772009061 putative substrate translocation pore; other site 632772009062 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772009063 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 632772009064 active site 632772009065 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772009066 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772009067 active site 632772009068 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 632772009069 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 632772009070 NAD(P) binding site [chemical binding]; other site 632772009071 hypothetical protein; Validated; Region: PRK07586 632772009072 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 632772009073 PYR/PP interface [polypeptide binding]; other site 632772009074 dimer interface [polypeptide binding]; other site 632772009075 TPP binding site [chemical binding]; other site 632772009076 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 632772009077 TPP-binding site [chemical binding]; other site 632772009078 dimer interface [polypeptide binding]; other site 632772009079 enoyl-CoA hydratase; Provisional; Region: PRK06688 632772009080 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772009081 substrate binding site [chemical binding]; other site 632772009082 oxyanion hole (OAH) forming residues; other site 632772009083 trimer interface [polypeptide binding]; other site 632772009084 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772009085 substrate binding site [chemical binding]; other site 632772009086 oxyanion hole (OAH) forming residues; other site 632772009087 trimer interface [polypeptide binding]; other site 632772009088 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 632772009089 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 632772009090 FMN binding site [chemical binding]; other site 632772009091 substrate binding site [chemical binding]; other site 632772009092 putative catalytic residue [active] 632772009093 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772009094 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772009095 active site 632772009096 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 632772009097 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 632772009098 dimer interface [polypeptide binding]; other site 632772009099 active site 632772009100 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 632772009101 CoA-transferase family III; Region: CoA_transf_3; pfam02515 632772009102 Transcriptional regulator [Transcription]; Region: LysR; COG0583 632772009103 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 632772009104 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 632772009105 dimerization interface [polypeptide binding]; other site 632772009106 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772009107 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 632772009108 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 632772009109 active site 632772009110 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 632772009111 CoA-transferase family III; Region: CoA_transf_3; pfam02515 632772009112 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772009113 putative substrate translocation pore; other site 632772009114 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632772009115 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 632772009116 MarR family; Region: MarR; pfam01047 632772009117 Domain of unknown function (DUF202); Region: DUF202; cl09954 632772009118 Domain of unknown function (DUF202); Region: DUF202; cl09954 632772009119 Domain of unknown function (DUF389); Region: DUF389; pfam04087 632772009120 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 632772009121 hydrophobic ligand binding site; other site 632772009122 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 632772009123 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 632772009124 metal binding site [ion binding]; metal-binding site 632772009125 putative dimer interface [polypeptide binding]; other site 632772009126 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772009127 D-galactonate transporter; Region: 2A0114; TIGR00893 632772009128 putative substrate translocation pore; other site 632772009129 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 632772009130 AsnC family; Region: AsnC_trans_reg; pfam01037 632772009131 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 632772009132 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 632772009133 AsnC family; Region: AsnC_trans_reg; pfam01037 632772009134 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772009135 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 632772009136 NAD(P) binding site [chemical binding]; other site 632772009137 active site 632772009138 YCII-related domain; Region: YCII; cl00999 632772009139 putative succinate dehydrogenase; Reviewed; Region: PRK12842 632772009140 Predicted oxidoreductase [General function prediction only]; Region: COG3573 632772009141 Transcriptional regulator [Transcription]; Region: IclR; COG1414 632772009142 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 632772009143 Bacterial transcriptional regulator; Region: IclR; pfam01614 632772009144 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772009145 metabolite-proton symporter; Region: 2A0106; TIGR00883 632772009146 putative substrate translocation pore; other site 632772009147 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772009148 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772009149 short chain dehydrogenase; Provisional; Region: PRK05872 632772009150 classical (c) SDRs; Region: SDR_c; cd05233 632772009151 NAD(P) binding site [chemical binding]; other site 632772009152 active site 632772009153 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 632772009154 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 632772009155 benzoate transport; Region: 2A0115; TIGR00895 632772009156 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772009157 putative substrate translocation pore; other site 632772009158 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 632772009159 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 632772009160 metal binding site [ion binding]; metal-binding site 632772009161 putative dimer interface [polypeptide binding]; other site 632772009162 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 632772009163 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 632772009164 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 632772009165 lipoyl synthase; Provisional; Region: PRK05481 632772009166 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632772009167 FeS/SAM binding site; other site 632772009168 Integrase core domain; Region: rve; pfam00665 632772009169 glycine dehydrogenase; Provisional; Region: PRK05367 632772009170 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 632772009171 tetramer interface [polypeptide binding]; other site 632772009172 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632772009173 catalytic residue [active] 632772009174 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 632772009175 tetramer interface [polypeptide binding]; other site 632772009176 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632772009177 catalytic residue [active] 632772009178 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 632772009179 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 632772009180 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 632772009181 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 632772009182 lipoyl attachment site [posttranslational modification]; other site 632772009183 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 632772009184 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 632772009185 dimer interface [polypeptide binding]; other site 632772009186 active site 632772009187 glycine-pyridoxal phosphate binding site [chemical binding]; other site 632772009188 folate binding site [chemical binding]; other site 632772009189 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 632772009190 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 632772009191 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 632772009192 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 632772009193 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 632772009194 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 632772009195 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 632772009196 CoA-transferase family III; Region: CoA_transf_3; pfam02515 632772009197 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 632772009198 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 632772009199 Transcriptional regulators [Transcription]; Region: FadR; COG2186 632772009200 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772009201 DNA-binding site [nucleotide binding]; DNA binding site 632772009202 FCD domain; Region: FCD; pfam07729 632772009203 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 632772009204 CoA-transferase family III; Region: CoA_transf_3; pfam02515 632772009205 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772009206 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772009207 active site 632772009208 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772009209 metabolite-proton symporter; Region: 2A0106; TIGR00883 632772009210 putative substrate translocation pore; other site 632772009211 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 632772009212 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 632772009213 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 632772009214 dimerization interface [polypeptide binding]; other site 632772009215 substrate binding pocket [chemical binding]; other site 632772009216 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 632772009217 Catalytic domain of Protein Kinases; Region: PKc; cd00180 632772009218 active site 632772009219 ATP binding site [chemical binding]; other site 632772009220 substrate binding site [chemical binding]; other site 632772009221 activation loop (A-loop); other site 632772009222 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 632772009223 AAA ATPase domain; Region: AAA_16; pfam13191 632772009224 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 632772009225 agmatinase; Region: agmatinase; TIGR01230 632772009226 oligomer interface [polypeptide binding]; other site 632772009227 putative active site [active] 632772009228 Mn binding site [ion binding]; other site 632772009229 benzoate transport; Region: 2A0115; TIGR00895 632772009230 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772009231 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772009232 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 632772009233 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 632772009234 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 632772009235 Cytochrome P450; Region: p450; cl12078 632772009236 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 632772009237 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 632772009238 FMN-binding pocket [chemical binding]; other site 632772009239 flavin binding motif; other site 632772009240 phosphate binding motif [ion binding]; other site 632772009241 beta-alpha-beta structure motif; other site 632772009242 NAD binding pocket [chemical binding]; other site 632772009243 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 632772009244 catalytic loop [active] 632772009245 iron binding site [ion binding]; other site 632772009246 tetracycline repressor protein TetR; Provisional; Region: PRK13756 632772009247 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772009248 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 632772009249 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 632772009250 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 632772009251 putative NAD(P) binding site [chemical binding]; other site 632772009252 Transcriptional regulator [Transcription]; Region: IclR; COG1414 632772009253 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 632772009254 Bacterial transcriptional regulator; Region: IclR; pfam01614 632772009255 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 632772009256 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 632772009257 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 632772009258 Walker A/P-loop; other site 632772009259 ATP binding site [chemical binding]; other site 632772009260 Q-loop/lid; other site 632772009261 ABC transporter signature motif; other site 632772009262 Walker B; other site 632772009263 D-loop; other site 632772009264 H-loop/switch region; other site 632772009265 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772009266 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772009267 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 632772009268 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 632772009269 putative hydrophobic ligand binding site [chemical binding]; other site 632772009270 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 632772009271 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 632772009272 non-specific DNA binding site [nucleotide binding]; other site 632772009273 salt bridge; other site 632772009274 sequence-specific DNA binding site [nucleotide binding]; other site 632772009275 Cupin domain; Region: Cupin_2; pfam07883 632772009276 metabolite-proton symporter; Region: 2A0106; TIGR00883 632772009277 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772009278 putative substrate translocation pore; other site 632772009279 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 632772009280 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 632772009281 CoA-transferase family III; Region: CoA_transf_3; pfam02515 632772009282 enoyl-CoA hydratase; Provisional; Region: PRK06494 632772009283 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772009284 substrate binding site [chemical binding]; other site 632772009285 oxyanion hole (OAH) forming residues; other site 632772009286 trimer interface [polypeptide binding]; other site 632772009287 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 632772009288 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 632772009289 inhibitor site; inhibition site 632772009290 active site 632772009291 dimer interface [polypeptide binding]; other site 632772009292 catalytic residue [active] 632772009293 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772009294 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 632772009295 NAD(P) binding site [chemical binding]; other site 632772009296 active site 632772009297 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 632772009298 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 632772009299 NAD(P) binding site [chemical binding]; other site 632772009300 catalytic residues [active] 632772009301 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 632772009302 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 632772009303 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 632772009304 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 632772009305 Predicted transcriptional regulator [Transcription]; Region: COG1959 632772009306 Transcriptional regulator; Region: Rrf2; pfam02082 632772009307 Transcription factor WhiB; Region: Whib; pfam02467 632772009308 pyruvate kinase; Provisional; Region: PRK06247 632772009309 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 632772009310 domain interfaces; other site 632772009311 active site 632772009312 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 632772009313 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 632772009314 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 632772009315 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 632772009316 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 632772009317 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 632772009318 potential catalytic triad [active] 632772009319 conserved cys residue [active] 632772009320 MarR family; Region: MarR_2; cl17246 632772009321 metabolite-proton symporter; Region: 2A0106; TIGR00883 632772009322 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772009323 putative substrate translocation pore; other site 632772009324 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 632772009325 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 632772009326 NAD(P) binding site [chemical binding]; other site 632772009327 Methyltransferase domain; Region: Methyltransf_23; pfam13489 632772009328 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772009329 S-adenosylmethionine binding site [chemical binding]; other site 632772009330 Putative zinc-finger; Region: zf-HC2; pfam13490 632772009331 Cupin domain; Region: Cupin_2; cl17218 632772009332 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 632772009333 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 632772009334 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 632772009335 Catalytic domain of Protein Kinases; Region: PKc; cd00180 632772009336 active site 632772009337 ATP binding site [chemical binding]; other site 632772009338 substrate binding site [chemical binding]; other site 632772009339 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 632772009340 substrate binding site [chemical binding]; other site 632772009341 activation loop (A-loop); other site 632772009342 activation loop (A-loop); other site 632772009343 Predicted ATPase [General function prediction only]; Region: COG3903 632772009344 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 632772009345 TPR motif; other site 632772009346 Tetratricopeptide repeat; Region: TPR_12; pfam13424 632772009347 binding surface 632772009348 Tetratricopeptide repeat; Region: TPR_12; pfam13424 632772009349 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632772009350 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632772009351 DNA binding residues [nucleotide binding] 632772009352 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 632772009353 MarR family; Region: MarR; pfam01047 632772009354 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772009355 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772009356 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632772009357 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632772009358 DNA binding residues [nucleotide binding] 632772009359 dimerization interface [polypeptide binding]; other site 632772009360 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772009361 S-adenosylmethionine binding site [chemical binding]; other site 632772009362 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 632772009363 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 632772009364 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 632772009365 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 632772009366 dimer interface [polypeptide binding]; other site 632772009367 active site 632772009368 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 632772009369 putative active site [active] 632772009370 putative catalytic site [active] 632772009371 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 632772009372 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 632772009373 dimer interface [polypeptide binding]; other site 632772009374 active site 632772009375 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772009376 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772009377 active site 632772009378 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772009379 CoA binding site [chemical binding]; other site 632772009380 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772009381 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772009382 active site 632772009383 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 632772009384 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772009385 NAD(P) binding site [chemical binding]; other site 632772009386 active site 632772009387 Transcriptional regulator [Transcription]; Region: LysR; COG0583 632772009388 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 632772009389 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 632772009390 dimerization interface [polypeptide binding]; other site 632772009391 Transcriptional regulator [Transcription]; Region: LysR; COG0583 632772009392 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 632772009393 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 632772009394 dimerization interface [polypeptide binding]; other site 632772009395 benzoate transport; Region: 2A0115; TIGR00895 632772009396 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 632772009397 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 632772009398 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 632772009399 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 632772009400 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 632772009401 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 632772009402 phosphate binding site [ion binding]; other site 632772009403 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 632772009404 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 632772009405 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772009406 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 632772009407 NAD(P) binding site [chemical binding]; other site 632772009408 active site 632772009409 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 632772009410 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 632772009411 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 632772009412 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 632772009413 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 632772009414 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 632772009415 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 632772009416 XdhC Rossmann domain; Region: XdhC_C; pfam13478 632772009417 Predicted amidohydrolase [General function prediction only]; Region: COG0388 632772009418 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 632772009419 putative active site [active] 632772009420 catalytic triad [active] 632772009421 putative dimer interface [polypeptide binding]; other site 632772009422 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 632772009423 putative hydrophobic ligand binding site [chemical binding]; other site 632772009424 hypothetical protein; Provisional; Region: PRK07236 632772009425 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 632772009426 Putative cyclase; Region: Cyclase; pfam04199 632772009427 Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876 632772009428 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 632772009429 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 632772009430 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 632772009431 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 632772009432 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 632772009433 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 632772009434 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 632772009435 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 632772009436 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 632772009437 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 632772009438 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 632772009439 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 632772009440 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 632772009441 catalytic loop [active] 632772009442 iron binding site [ion binding]; other site 632772009443 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 632772009444 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 632772009445 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 632772009446 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 632772009447 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 632772009448 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 632772009449 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 632772009450 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 632772009451 catalytic loop [active] 632772009452 iron binding site [ion binding]; other site 632772009453 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 632772009454 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 632772009455 FAD binding domain; Region: FAD_binding_4; pfam01565 632772009456 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 632772009457 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 632772009458 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 632772009459 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 632772009460 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 632772009461 inhibitor-cofactor binding pocket; inhibition site 632772009462 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632772009463 catalytic residue [active] 632772009464 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 632772009465 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 632772009466 NAD(P) binding site [chemical binding]; other site 632772009467 catalytic residues [active] 632772009468 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 632772009469 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 632772009470 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 632772009471 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 632772009472 putative molybdopterin cofactor binding site [chemical binding]; other site 632772009473 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 632772009474 putative molybdopterin cofactor binding site; other site 632772009475 hypothetical protein; Provisional; Region: PRK06184 632772009476 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 632772009477 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 632772009478 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 632772009479 dimer interface [polypeptide binding]; other site 632772009480 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 632772009481 active site 632772009482 Fe binding site [ion binding]; other site 632772009483 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 632772009484 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 632772009485 putative DNA binding site [nucleotide binding]; other site 632772009486 putative Zn2+ binding site [ion binding]; other site 632772009487 AsnC family; Region: AsnC_trans_reg; pfam01037 632772009488 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 632772009489 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 632772009490 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 632772009491 NAD(P) binding pocket [chemical binding]; other site 632772009492 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 632772009493 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 632772009494 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 632772009495 active site 632772009496 FMN binding site [chemical binding]; other site 632772009497 substrate binding site [chemical binding]; other site 632772009498 putative catalytic residue [active] 632772009499 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 632772009500 putative hydrophobic ligand binding site [chemical binding]; other site 632772009501 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632772009502 dimerization interface [polypeptide binding]; other site 632772009503 putative DNA binding site [nucleotide binding]; other site 632772009504 putative Zn2+ binding site [ion binding]; other site 632772009505 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 632772009506 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 632772009507 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 632772009508 AAA domain; Region: AAA_33; pfam13671 632772009509 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 632772009510 Catalytic domain of Protein Kinases; Region: PKc; cd00180 632772009511 active site 632772009512 ATP binding site [chemical binding]; other site 632772009513 substrate binding site [chemical binding]; other site 632772009514 activation loop (A-loop); other site 632772009515 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772009516 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772009517 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 632772009518 Protein of unknown function (DUF664); Region: DUF664; pfam04978 632772009519 DinB superfamily; Region: DinB_2; pfam12867 632772009520 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 632772009521 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 632772009522 MMPL family; Region: MMPL; pfam03176 632772009523 MMPL family; Region: MMPL; pfam03176 632772009524 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 632772009525 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632772009526 putative Zn2+ binding site [ion binding]; other site 632772009527 putative DNA binding site [nucleotide binding]; other site 632772009528 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 632772009529 binding surface 632772009530 TPR motif; other site 632772009531 Tetratricopeptide repeat; Region: TPR_12; pfam13424 632772009532 peroxiredoxin; Region: AhpC; TIGR03137 632772009533 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 632772009534 dimer interface [polypeptide binding]; other site 632772009535 decamer (pentamer of dimers) interface [polypeptide binding]; other site 632772009536 catalytic triad [active] 632772009537 peroxidatic and resolving cysteines [active] 632772009538 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 632772009539 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 632772009540 catalytic residue [active] 632772009541 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 632772009542 catalytic residues [active] 632772009543 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 632772009544 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 632772009545 CHAT domain; Region: CHAT; cl17868 632772009546 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 632772009547 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 632772009548 dimer interface [polypeptide binding]; other site 632772009549 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 632772009550 hypothetical protein; Provisional; Region: PRK07588 632772009551 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772009552 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772009553 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 632772009554 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 632772009555 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 632772009556 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 632772009557 amidase; Provisional; Region: PRK07486 632772009558 Amidase; Region: Amidase; cl11426 632772009559 ring-opening amidohydrolases; Region: amido_AtzD_TrzD; TIGR02714 632772009560 Domain of unknown function (DUF385); Region: DUF385; cl04387 632772009561 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632772009562 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632772009563 DNA binding residues [nucleotide binding] 632772009564 dimerization interface [polypeptide binding]; other site 632772009565 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 632772009566 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 632772009567 classical (c) SDRs; Region: SDR_c; cd05233 632772009568 NAD(P) binding site [chemical binding]; other site 632772009569 active site 632772009570 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 632772009571 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 632772009572 NAD(P) binding site [chemical binding]; other site 632772009573 catalytic residues [active] 632772009574 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 632772009575 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 632772009576 putative NAD(P) binding site [chemical binding]; other site 632772009577 benzoate transport; Region: 2A0115; TIGR00895 632772009578 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772009579 putative substrate translocation pore; other site 632772009580 Cupin domain; Region: Cupin_2; cl17218 632772009581 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 632772009582 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 632772009583 NAD binding site [chemical binding]; other site 632772009584 catalytic Zn binding site [ion binding]; other site 632772009585 substrate binding site [chemical binding]; other site 632772009586 structural Zn binding site [ion binding]; other site 632772009587 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 632772009588 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 632772009589 NAD(P) binding site [chemical binding]; other site 632772009590 catalytic residues [active] 632772009591 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 632772009592 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 632772009593 classical (c) SDRs; Region: SDR_c; cd05233 632772009594 NAD(P) binding site [chemical binding]; other site 632772009595 active site 632772009596 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 632772009597 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 632772009598 potential frameshift: common BLAST hit: gi|170781704|ref|YP_001710036.1| integral membrane transport protein 632772009599 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772009600 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632772009601 putative substrate translocation pore; other site 632772009602 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632772009603 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772009604 metabolite-proton symporter; Region: 2A0106; TIGR00883 632772009605 putative substrate translocation pore; other site 632772009606 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 632772009607 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 632772009608 CoA-transferase family III; Region: CoA_transf_3; pfam02515 632772009609 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 632772009610 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772009611 substrate binding site [chemical binding]; other site 632772009612 oxyanion hole (OAH) forming residues; other site 632772009613 trimer interface [polypeptide binding]; other site 632772009614 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 632772009615 CoA-transferase family III; Region: CoA_transf_3; pfam02515 632772009616 Transcriptional regulators [Transcription]; Region: GntR; COG1802 632772009617 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772009618 DNA-binding site [nucleotide binding]; DNA binding site 632772009619 FCD domain; Region: FCD; pfam07729 632772009620 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 632772009621 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772009622 active site 632772009623 acetate--CoA ligase; Region: Ac_CoA_lig_AcsA; TIGR02188 632772009624 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 632772009625 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772009626 acyl-activating enzyme (AAE) consensus motif; other site 632772009627 AMP binding site [chemical binding]; other site 632772009628 active site 632772009629 CoA binding site [chemical binding]; other site 632772009630 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 632772009631 putative active site [active] 632772009632 putative catalytic site [active] 632772009633 Transcriptional regulators [Transcription]; Region: GntR; COG1802 632772009634 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772009635 DNA-binding site [nucleotide binding]; DNA binding site 632772009636 FCD domain; Region: FCD; pfam07729 632772009637 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 632772009638 CoA-transferase family III; Region: CoA_transf_3; pfam02515 632772009639 Transcriptional regulators [Transcription]; Region: GntR; COG1802 632772009640 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 632772009641 DNA-binding site [nucleotide binding]; DNA binding site 632772009642 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 632772009643 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 632772009644 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 632772009645 aspartate aminotransferase; Provisional; Region: PRK06107 632772009646 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 632772009647 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632772009648 homodimer interface [polypeptide binding]; other site 632772009649 catalytic residue [active] 632772009650 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 632772009651 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 632772009652 putative NAD(P) binding site [chemical binding]; other site 632772009653 catalytic Zn binding site [ion binding]; other site 632772009654 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 632772009655 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772009656 NAD(P) binding site [chemical binding]; other site 632772009657 active site 632772009658 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772009659 metabolite-proton symporter; Region: 2A0106; TIGR00883 632772009660 putative substrate translocation pore; other site 632772009661 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 632772009662 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 632772009663 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 632772009664 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 632772009665 putative active site [active] 632772009666 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 632772009667 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 632772009668 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 632772009669 putative dimerization interface [polypeptide binding]; other site 632772009670 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159 632772009671 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 632772009672 putative ligand binding site [chemical binding]; other site 632772009673 putative NAD binding site [chemical binding]; other site 632772009674 catalytic site [active] 632772009675 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 632772009676 gluconate 5-dehydrogenase; Provisional; Region: PRK07523 632772009677 NADP binding site [chemical binding]; other site 632772009678 homodimer interface [polypeptide binding]; other site 632772009679 active site 632772009680 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 632772009681 AAA domain; Region: AAA_33; pfam13671 632772009682 ATP-binding site [chemical binding]; other site 632772009683 Gluconate-6-phosphate binding site [chemical binding]; other site 632772009684 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 632772009685 tetramer interface [polypeptide binding]; other site 632772009686 TPP-binding site [chemical binding]; other site 632772009687 heterodimer interface [polypeptide binding]; other site 632772009688 phosphorylation loop region [posttranslational modification] 632772009689 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 632772009690 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 632772009691 PYR/PP interface [polypeptide binding]; other site 632772009692 dimer interface [polypeptide binding]; other site 632772009693 TPP binding site [chemical binding]; other site 632772009694 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 632772009695 Transcriptional regulator [Transcription]; Region: LysR; COG0583 632772009696 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 632772009697 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 632772009698 putative dimerization interface [polypeptide binding]; other site 632772009699 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 632772009700 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 632772009701 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 632772009702 NAD(P) binding site [chemical binding]; other site 632772009703 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 632772009704 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 632772009705 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 632772009706 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 632772009707 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 632772009708 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 632772009709 dinuclear metal binding motif [ion binding]; other site 632772009710 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 632772009711 aldehyde dehydrogenase family 7 member; Region: PLN02315 632772009712 tetrameric interface [polypeptide binding]; other site 632772009713 NAD binding site [chemical binding]; other site 632772009714 catalytic residues [active] 632772009715 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 632772009716 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 632772009717 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 632772009718 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 632772009719 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 632772009720 Walker A/P-loop; other site 632772009721 ATP binding site [chemical binding]; other site 632772009722 Q-loop/lid; other site 632772009723 ABC transporter signature motif; other site 632772009724 Walker B; other site 632772009725 D-loop; other site 632772009726 H-loop/switch region; other site 632772009727 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 632772009728 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 632772009729 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 632772009730 Walker A/P-loop; other site 632772009731 ATP binding site [chemical binding]; other site 632772009732 Q-loop/lid; other site 632772009733 ABC transporter signature motif; other site 632772009734 Walker B; other site 632772009735 D-loop; other site 632772009736 H-loop/switch region; other site 632772009737 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 632772009738 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 632772009739 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772009740 dimer interface [polypeptide binding]; other site 632772009741 conserved gate region; other site 632772009742 putative PBP binding loops; other site 632772009743 ABC-ATPase subunit interface; other site 632772009744 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 632772009745 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772009746 dimer interface [polypeptide binding]; other site 632772009747 conserved gate region; other site 632772009748 putative PBP binding loops; other site 632772009749 ABC-ATPase subunit interface; other site 632772009750 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 632772009751 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 632772009752 peptide binding site [polypeptide binding]; other site 632772009753 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 632772009754 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 632772009755 NAD binding site [chemical binding]; other site 632772009756 catalytic residues [active] 632772009757 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 632772009758 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 632772009759 [2Fe-2S] cluster binding site [ion binding]; other site 632772009760 Ring hydroxylating alpha subunit (catalytic domain); Region: Ring_hydroxyl_A; pfam00848 632772009761 hydrophobic ligand binding site; other site 632772009762 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 632772009763 short chain dehydrogenase; Provisional; Region: PRK07677 632772009764 NAD(P) binding site [chemical binding]; other site 632772009765 substrate binding site [chemical binding]; other site 632772009766 homotetramer interface [polypeptide binding]; other site 632772009767 active site 632772009768 homodimer interface [polypeptide binding]; other site 632772009769 Acyl-CoA dehydrogenase, C-terminal domain; Region: Acyl-CoA_dh_1; pfam00441 632772009770 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 632772009771 CoA-transferase family III; Region: CoA_transf_3; pfam02515 632772009772 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772009773 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 632772009774 active site 632772009775 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 632772009776 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 632772009777 FMN-binding pocket [chemical binding]; other site 632772009778 flavin binding motif; other site 632772009779 phosphate binding motif [ion binding]; other site 632772009780 beta-alpha-beta structure motif; other site 632772009781 NAD binding pocket [chemical binding]; other site 632772009782 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 632772009783 catalytic loop [active] 632772009784 iron binding site [ion binding]; other site 632772009785 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 632772009786 Transcriptional regulator [Transcription]; Region: IclR; COG1414 632772009787 Bacterial transcriptional regulator; Region: IclR; pfam01614 632772009788 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 632772009789 MspA; Region: MspA; pfam09203 632772009790 MspA; Region: MspA; pfam09203 632772009791 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 632772009792 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 632772009793 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 632772009794 putative active site [active] 632772009795 catalytic residue [active] 632772009796 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 632772009797 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 632772009798 NAD binding site [chemical binding]; other site 632772009799 catalytic residues [active] 632772009800 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 632772009801 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 632772009802 dimer interface [polypeptide binding]; other site 632772009803 active site 632772009804 potential frameshift: common BLAST hit: gi|54026972|ref|YP_121214.1| glucose-6-phosphate isomerase 632772009805 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 632772009806 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632772009807 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632772009808 DNA binding residues [nucleotide binding] 632772009809 Transcriptional regulator [Transcription]; Region: LysR; COG0583 632772009810 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 632772009811 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 632772009812 dimerization interface [polypeptide binding]; other site 632772009813 substrate binding pocket [chemical binding]; other site 632772009814 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 632772009815 EamA-like transporter family; Region: EamA; pfam00892 632772009816 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 632772009817 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 632772009818 TPP-binding site [chemical binding]; other site 632772009819 PYR/PP interface [polypeptide binding]; other site 632772009820 dimer interface [polypeptide binding]; other site 632772009821 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 632772009822 TPP binding site [chemical binding]; other site 632772009823 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 632772009824 Peptidase family M48; Region: Peptidase_M48; pfam01435 632772009825 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 632772009826 Sulfatase; Region: Sulfatase; pfam00884 632772009827 Predicted membrane protein [Function unknown]; Region: COG4129 632772009828 Transcriptional regulators [Transcription]; Region: GntR; COG1802 632772009829 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772009830 DNA-binding site [nucleotide binding]; DNA binding site 632772009831 FCD domain; Region: FCD; pfam07729 632772009832 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 632772009833 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 632772009834 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 632772009835 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 632772009836 putative active site [active] 632772009837 putative NTP binding site [chemical binding]; other site 632772009838 putative nucleic acid binding site [nucleotide binding]; other site 632772009839 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 632772009840 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 632772009841 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 632772009842 CoA-transferase family III; Region: CoA_transf_3; pfam02515 632772009843 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 632772009844 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772009845 substrate binding site [chemical binding]; other site 632772009846 oxyanion hole (OAH) forming residues; other site 632772009847 trimer interface [polypeptide binding]; other site 632772009848 acetate--CoA ligase; Region: Ac_CoA_lig_AcsA; TIGR02188 632772009849 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 632772009850 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772009851 acyl-activating enzyme (AAE) consensus motif; other site 632772009852 AMP binding site [chemical binding]; other site 632772009853 active site 632772009854 CoA binding site [chemical binding]; other site 632772009855 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 632772009856 putative active site [active] 632772009857 putative catalytic site [active] 632772009858 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772009859 metabolite-proton symporter; Region: 2A0106; TIGR00883 632772009860 putative substrate translocation pore; other site 632772009861 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 632772009862 CoA-transferase family III; Region: CoA_transf_3; pfam02515 632772009863 Nitronate monooxygenase; Region: NMO; pfam03060 632772009864 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 632772009865 FMN binding site [chemical binding]; other site 632772009866 substrate binding site [chemical binding]; other site 632772009867 putative catalytic residue [active] 632772009868 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 632772009869 CoA-transferase family III; Region: CoA_transf_3; pfam02515 632772009870 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 632772009871 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 632772009872 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772009873 NAD(P) binding site [chemical binding]; other site 632772009874 active site 632772009875 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 632772009876 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 632772009877 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 632772009878 Predicted ATPase [General function prediction only]; Region: COG3903 632772009879 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632772009880 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632772009881 DNA binding residues [nucleotide binding] 632772009882 dimerization interface [polypeptide binding]; other site 632772009883 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 632772009884 Walker A motif; other site 632772009885 ATP binding site [chemical binding]; other site 632772009886 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 632772009887 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 632772009888 active site 632772009889 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 632772009890 active site 632772009891 NTP binding site [chemical binding]; other site 632772009892 metal binding triad [ion binding]; metal-binding site 632772009893 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 632772009894 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 632772009895 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 632772009896 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 632772009897 oligomer interface [polypeptide binding]; other site 632772009898 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 632772009899 PPOX class probable F420-dependent enzyme, Rv3369 family; Region: Rv3369; TIGR03667 632772009900 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 632772009901 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 632772009902 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 632772009903 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 632772009904 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 632772009905 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 632772009906 E3 interaction surface; other site 632772009907 lipoyl attachment site [posttranslational modification]; other site 632772009908 e3 binding domain; Region: E3_binding; pfam02817 632772009909 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 632772009910 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 632772009911 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 632772009912 alpha subunit interface [polypeptide binding]; other site 632772009913 TPP binding site [chemical binding]; other site 632772009914 heterodimer interface [polypeptide binding]; other site 632772009915 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 632772009916 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 632772009917 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 632772009918 tetramer interface [polypeptide binding]; other site 632772009919 TPP-binding site [chemical binding]; other site 632772009920 heterodimer interface [polypeptide binding]; other site 632772009921 phosphorylation loop region [posttranslational modification] 632772009922 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 632772009923 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 632772009924 putative DNA binding site [nucleotide binding]; other site 632772009925 putative Zn2+ binding site [ion binding]; other site 632772009926 AsnC family; Region: AsnC_trans_reg; pfam01037 632772009927 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 632772009928 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 632772009929 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 632772009930 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 632772009931 Domain of unknown function DUF21; Region: DUF21; pfam01595 632772009932 FOG: CBS domain [General function prediction only]; Region: COG0517 632772009933 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 632772009934 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 632772009935 Domain of unknown function DUF21; Region: DUF21; pfam01595 632772009936 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 632772009937 Transporter associated domain; Region: CorC_HlyC; pfam03471 632772009938 ERCC4 domain; Region: ERCC4; pfam02732 632772009939 Lsr2; Region: Lsr2; pfam11774 632772009940 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 632772009941 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632772009942 putative DNA binding site [nucleotide binding]; other site 632772009943 putative Zn2+ binding site [ion binding]; other site 632772009944 AsnC family; Region: AsnC_trans_reg; pfam01037 632772009945 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 632772009946 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 632772009947 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 632772009948 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 632772009949 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 632772009950 Cytochrome P450; Region: p450; cl12078 632772009951 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 632772009952 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 632772009953 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632772009954 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 632772009955 YCII-related domain; Region: YCII; cl00999 632772009956 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 632772009957 Beta-lactamase; Region: Beta-lactamase; pfam00144 632772009958 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 632772009959 Amidohydrolase; Region: Amidohydro_2; pfam04909 632772009960 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 632772009961 TAP-like protein; Region: Abhydrolase_4; pfam08386 632772009962 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 632772009963 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 632772009964 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 632772009965 HEAT repeats; Region: HEAT_2; pfam13646 632772009966 HEAT repeats; Region: HEAT_2; pfam13646 632772009967 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 632772009968 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 632772009969 DNA binding residues [nucleotide binding] 632772009970 putative dimer interface [polypeptide binding]; other site 632772009971 HEAT repeats; Region: HEAT_2; pfam13646 632772009972 Lsr2; Region: Lsr2; pfam11774 632772009973 Lsr2; Region: Lsr2; pfam11774 632772009974 Lsr2; Region: Lsr2; pfam11774 632772009975 Lsr2; Region: Lsr2; pfam11774 632772009976 Lsr2; Region: Lsr2; pfam11774 632772009977 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772009978 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772009979 active site 632772009980 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 632772009981 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 632772009982 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 632772009983 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 632772009984 DNA binding residues [nucleotide binding] 632772009985 putative dimer interface [polypeptide binding]; other site 632772009986 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 632772009987 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 632772009988 putative NAD(P) binding site [chemical binding]; other site 632772009989 putative substrate binding site [chemical binding]; other site 632772009990 catalytic Zn binding site [ion binding]; other site 632772009991 structural Zn binding site [ion binding]; other site 632772009992 dimer interface [polypeptide binding]; other site 632772009993 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 632772009994 Spore germination protein; Region: Spore_permease; cl17796 632772009995 potential frameshift: common BLAST hit: gi|111018401|ref|YP_701373.1| NAD-specific glutamate dehydrogenase 632772009996 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 632772009997 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 632772009998 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 632772009999 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 632772010000 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 632772010001 Glutamate binding site [chemical binding]; other site 632772010002 NAD binding site [chemical binding]; other site 632772010003 catalytic residues [active] 632772010004 Proline dehydrogenase; Region: Pro_dh; cl03282 632772010005 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 632772010006 Cupin domain; Region: Cupin_2; pfam07883 632772010007 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 632772010008 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 632772010009 active site 632772010010 catalytic tetrad [active] 632772010011 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 632772010012 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 632772010013 Transcriptional regulators [Transcription]; Region: FadR; COG2186 632772010014 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772010015 DNA-binding site [nucleotide binding]; DNA binding site 632772010016 FCD domain; Region: FCD; pfam07729 632772010017 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772010018 metabolite-proton symporter; Region: 2A0106; TIGR00883 632772010019 putative substrate translocation pore; other site 632772010020 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 632772010021 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 632772010022 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 632772010023 Fructose-bisphosphate aldolase class-II; Region: F_bP_aldolase; pfam01116 632772010024 active site 632772010025 intersubunit interface [polypeptide binding]; other site 632772010026 zinc binding site [ion binding]; other site 632772010027 Na+ binding site [ion binding]; other site 632772010028 SnoaL-like domain; Region: SnoaL_2; pfam12680 632772010029 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 632772010030 fumarate hydratase; Provisional; Region: PLN00134 632772010031 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 632772010032 tetramer interface [polypeptide binding]; other site 632772010033 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 632772010034 active site 632772010035 homotetramer interface [polypeptide binding]; other site 632772010036 homodimer interface [polypeptide binding]; other site 632772010037 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 632772010038 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 632772010039 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 632772010040 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 632772010041 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 632772010042 active site 632772010043 DUF35 OB-fold domain; Region: DUF35; pfam01796 632772010044 Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016 632772010045 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 632772010046 active site 632772010047 catalytic residues [active] 632772010048 metal binding site [ion binding]; metal-binding site 632772010049 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 632772010050 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 632772010051 ATP-grasp domain; Region: ATP-grasp_4; cl17255 632772010052 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 632772010053 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 632772010054 carboxyltransferase (CT) interaction site; other site 632772010055 biotinylation site [posttranslational modification]; other site 632772010056 pyruvate phosphate dikinase; Provisional; Region: PRK05878 632772010057 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 632772010058 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 632772010059 acyl-CoA synthetase; Validated; Region: PRK06188 632772010060 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772010061 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 632772010062 acyl-activating enzyme (AAE) consensus motif; other site 632772010063 acyl-activating enzyme (AAE) consensus motif; other site 632772010064 putative AMP binding site [chemical binding]; other site 632772010065 putative active site [active] 632772010066 putative CoA binding site [chemical binding]; other site 632772010067 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 632772010068 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632772010069 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632772010070 DNA binding residues [nucleotide binding] 632772010071 dimerization interface [polypeptide binding]; other site 632772010072 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 632772010073 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 632772010074 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 632772010075 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 632772010076 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 632772010077 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 632772010078 Walker A/P-loop; other site 632772010079 ATP binding site [chemical binding]; other site 632772010080 Q-loop/lid; other site 632772010081 ABC transporter signature motif; other site 632772010082 Walker B; other site 632772010083 D-loop; other site 632772010084 H-loop/switch region; other site 632772010085 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 632772010086 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 632772010087 Walker A/P-loop; other site 632772010088 ATP binding site [chemical binding]; other site 632772010089 Q-loop/lid; other site 632772010090 ABC transporter signature motif; other site 632772010091 Walker B; other site 632772010092 D-loop; other site 632772010093 H-loop/switch region; other site 632772010094 Predicted transcriptional regulators [Transcription]; Region: COG1733 632772010095 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 632772010096 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 632772010097 tetracycline repressor protein TetR; Provisional; Region: PRK13756 632772010098 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772010099 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 632772010100 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 632772010101 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 632772010102 putative di-iron ligands [ion binding]; other site 632772010103 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 632772010104 Transcription factor WhiB; Region: Whib; pfam02467 632772010105 amino acid transporter; Region: 2A0306; TIGR00909 632772010106 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632772010107 dimerization interface [polypeptide binding]; other site 632772010108 putative DNA binding site [nucleotide binding]; other site 632772010109 putative Zn2+ binding site [ion binding]; other site 632772010110 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 632772010111 arsenical-resistance protein; Region: acr3; TIGR00832 632772010112 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 632772010113 Low molecular weight phosphatase family; Region: LMWPc; cd00115 632772010114 active site 632772010115 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 632772010116 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 632772010117 putative NAD(P) binding site [chemical binding]; other site 632772010118 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 632772010119 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 632772010120 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 632772010121 active site residue [active] 632772010122 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 632772010123 active site residue [active] 632772010124 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 632772010125 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 632772010126 Catalytic domain of Protein Kinases; Region: PKc; cd00180 632772010127 active site 632772010128 ATP binding site [chemical binding]; other site 632772010129 substrate binding site [chemical binding]; other site 632772010130 activation loop (A-loop); other site 632772010131 AAA ATPase domain; Region: AAA_16; pfam13191 632772010132 Predicted ATPase [General function prediction only]; Region: COG3903 632772010133 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632772010134 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632772010135 DNA binding residues [nucleotide binding] 632772010136 dimerization interface [polypeptide binding]; other site 632772010137 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772010138 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772010139 Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: PI3Kc_like; cl00119 632772010140 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 632772010141 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 632772010142 FMN-binding pocket [chemical binding]; other site 632772010143 flavin binding motif; other site 632772010144 phosphate binding motif [ion binding]; other site 632772010145 beta-alpha-beta structure motif; other site 632772010146 NAD binding pocket [chemical binding]; other site 632772010147 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 632772010148 catalytic loop [active] 632772010149 iron binding site [ion binding]; other site 632772010150 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 632772010151 Cytochrome P450; Region: p450; cl12078 632772010152 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 632772010153 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 632772010154 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 632772010155 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 632772010156 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 632772010157 NAD(P) binding site [chemical binding]; other site 632772010158 MspA; Region: MspA; pfam09203 632772010159 MspA; Region: MspA; pfam09203 632772010160 Catalytic domain of Protein Kinases; Region: PKc; cd00180 632772010161 substrate binding site [chemical binding]; other site 632772010162 activation loop (A-loop); other site 632772010163 Predicted ATPase [General function prediction only]; Region: COG3903 632772010164 Tetratricopeptide repeat; Region: TPR_12; pfam13424 632772010165 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632772010166 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632772010167 DNA binding residues [nucleotide binding] 632772010168 dimerization interface [polypeptide binding]; other site 632772010169 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 632772010170 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 632772010171 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 632772010172 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 632772010173 NAD(P) binding site [chemical binding]; other site 632772010174 catalytic residues [active] 632772010175 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 632772010176 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 632772010177 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 632772010178 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 632772010179 catalytic residue [active] 632772010180 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 632772010181 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 632772010182 catalytic triad [active] 632772010183 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 632772010184 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 632772010185 NAD binding site [chemical binding]; other site 632772010186 catalytic Zn binding site [ion binding]; other site 632772010187 substrate binding site [chemical binding]; other site 632772010188 structural Zn binding site [ion binding]; other site 632772010189 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 632772010190 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 632772010191 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 632772010192 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 632772010193 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 632772010194 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 632772010195 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 632772010196 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 632772010197 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 632772010198 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 632772010199 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 632772010200 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 632772010201 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 632772010202 dimer interface [polypeptide binding]; other site 632772010203 acyl-activating enzyme (AAE) consensus motif; other site 632772010204 putative active site [active] 632772010205 AMP binding site [chemical binding]; other site 632772010206 putative CoA binding site [chemical binding]; other site 632772010207 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 632772010208 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772010209 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772010210 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 632772010211 AsnC family; Region: AsnC_trans_reg; pfam01037 632772010212 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 632772010213 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772010214 putative substrate translocation pore; other site 632772010215 enoyl-CoA hydratase; Provisional; Region: PRK06144 632772010216 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772010217 substrate binding site [chemical binding]; other site 632772010218 oxyanion hole (OAH) forming residues; other site 632772010219 trimer interface [polypeptide binding]; other site 632772010220 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 632772010221 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 632772010222 THF binding site; other site 632772010223 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 632772010224 substrate binding site [chemical binding]; other site 632772010225 THF binding site; other site 632772010226 zinc-binding site [ion binding]; other site 632772010227 Transcriptional regulator [Transcription]; Region: LysR; COG0583 632772010228 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 632772010229 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 632772010230 dimerization interface [polypeptide binding]; other site 632772010231 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 632772010232 methionine synthase; Provisional; Region: PRK01207 632772010233 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 632772010234 substrate binding site [chemical binding]; other site 632772010235 THF binding site; other site 632772010236 zinc-binding site [ion binding]; other site 632772010237 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 632772010238 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 632772010239 Walker A/P-loop; other site 632772010240 ATP binding site [chemical binding]; other site 632772010241 Q-loop/lid; other site 632772010242 ABC transporter signature motif; other site 632772010243 Walker B; other site 632772010244 D-loop; other site 632772010245 H-loop/switch region; other site 632772010246 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 632772010247 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 632772010248 ABC-ATPase subunit interface; other site 632772010249 dimer interface [polypeptide binding]; other site 632772010250 putative PBP binding regions; other site 632772010251 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 632772010252 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 632772010253 putative ligand binding residues [chemical binding]; other site 632772010254 citrate synthase; Provisional; Region: PRK14033 632772010255 Cold-active citrate synthase (CS) from an Antarctic bacterial strain DS2-3R (Ds)-like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or...; Region: DsCS_like; cd06111 632772010256 dimer interface [polypeptide binding]; other site 632772010257 active site 632772010258 citrylCoA binding site [chemical binding]; other site 632772010259 oxalacetate/citrate binding site [chemical binding]; other site 632772010260 coenzyme A binding site [chemical binding]; other site 632772010261 catalytic triad [active] 632772010262 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 632772010263 tetramer interface [polypeptide binding]; other site 632772010264 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 632772010265 active site 632772010266 Mg2+/Mn2+ binding site [ion binding]; other site 632772010267 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 632772010268 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 632772010269 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 632772010270 sequence-specific DNA binding site [nucleotide binding]; other site 632772010271 salt bridge; other site 632772010272 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 632772010273 Domain of unknown function (DUF955); Region: DUF955; pfam06114 632772010274 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 632772010275 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 632772010276 dimerization interface [polypeptide binding]; other site 632772010277 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 632772010278 FAD binding domain; Region: FAD_binding_4; pfam01565 632772010279 Berberine and berberine like; Region: BBE; pfam08031 632772010280 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 632772010281 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 632772010282 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 632772010283 Protein of unknown function (DUF461); Region: DUF461; pfam04314 632772010284 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 632772010285 multidrug resistance protein MdtH; Provisional; Region: PRK11646 632772010286 FAD binding domain; Region: FAD_binding_4; pfam01565 632772010287 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 632772010288 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 632772010289 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 632772010290 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772010291 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772010292 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772010293 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772010294 active site 632772010295 putative acyltransferase; Provisional; Region: PRK05790 632772010296 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 632772010297 dimer interface [polypeptide binding]; other site 632772010298 active site 632772010299 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 632772010300 4-coumarate--CoA ligase; Region: PLN02246 632772010301 4-Coumarate-CoA Ligase (4CL); Region: 4CL; cd05904 632772010302 acyl-activating enzyme (AAE) consensus motif; other site 632772010303 active site 632772010304 putative CoA binding site [chemical binding]; other site 632772010305 AMP binding site [chemical binding]; other site 632772010306 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772010307 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 632772010308 putative substrate translocation pore; other site 632772010309 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 632772010310 active site 632772010311 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 632772010312 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772010313 putative substrate translocation pore; other site 632772010314 Transcriptional regulator [Transcription]; Region: IclR; COG1414 632772010315 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 632772010316 CoA-transferase family III; Region: CoA_transf_3; pfam02515 632772010317 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 632772010318 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772010319 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772010320 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772010321 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 632772010322 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772010323 putative substrate translocation pore; other site 632772010324 enoyl-CoA hydratase; Provisional; Region: PRK06688 632772010325 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772010326 substrate binding site [chemical binding]; other site 632772010327 oxyanion hole (OAH) forming residues; other site 632772010328 trimer interface [polypeptide binding]; other site 632772010329 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 632772010330 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 632772010331 NAD(P) binding site [chemical binding]; other site 632772010332 catalytic residues [active] 632772010333 sulfopyruvate decarboxylase, beta subunit; Region: sulfopy_beta; TIGR03846 632772010334 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 632772010335 TPP-binding site [chemical binding]; other site 632772010336 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 632772010337 PYR/PP interface [polypeptide binding]; other site 632772010338 dimer interface [polypeptide binding]; other site 632772010339 TPP binding site [chemical binding]; other site 632772010340 Transcriptional regulator [Transcription]; Region: LysR; COG0583 632772010341 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 632772010342 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 632772010343 putative dimerization interface [polypeptide binding]; other site 632772010344 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 632772010345 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 632772010346 potential frameshift: common BLAST hit: gi|111017138|ref|YP_700110.1| resolvase, N-terminal 632772010347 multiple promoter invertase; Provisional; Region: mpi; PRK13413 632772010348 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 632772010349 catalytic residues [active] 632772010350 catalytic nucleophile [active] 632772010351 Presynaptic Site I dimer interface [polypeptide binding]; other site 632772010352 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 632772010353 Synaptic Flat tetramer interface [polypeptide binding]; other site 632772010354 Synaptic Site I dimer interface [polypeptide binding]; other site 632772010355 DNA binding site [nucleotide binding] 632772010356 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 632772010357 DNA-binding interface [nucleotide binding]; DNA binding site 632772010358 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 632772010359 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 632772010360 non-specific DNA binding site [nucleotide binding]; other site 632772010361 salt bridge; other site 632772010362 sequence-specific DNA binding site [nucleotide binding]; other site 632772010363 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 632772010364 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 632772010365 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 632772010366 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 632772010367 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 632772010368 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 632772010369 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 632772010370 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 632772010371 DNA binding residues [nucleotide binding] 632772010372 putative dimer interface [polypeptide binding]; other site 632772010373 SnoaL-like domain; Region: SnoaL_3; pfam13474 632772010374 SnoaL-like domain; Region: SnoaL_4; pfam13577 632772010375 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 632772010376 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 632772010377 AAA ATPase domain; Region: AAA_16; pfam13191 632772010378 AAA domain; Region: AAA_22; pfam13401 632772010379 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 632772010380 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 632772010381 FMN binding site [chemical binding]; other site 632772010382 active site 632772010383 substrate binding site [chemical binding]; other site 632772010384 catalytic residue [active] 632772010385 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632772010386 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632772010387 DNA binding residues [nucleotide binding] 632772010388 dimerization interface [polypeptide binding]; other site 632772010389 Cupin domain; Region: Cupin_2; cl17218 632772010390 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 632772010391 active site 2 [active] 632772010392 active site 1 [active] 632772010393 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 632772010394 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 632772010395 putative active site [active] 632772010396 putative catalytic site [active] 632772010397 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 632772010398 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 632772010399 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 632772010400 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 632772010401 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 632772010402 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 632772010403 Walker A/P-loop; other site 632772010404 ATP binding site [chemical binding]; other site 632772010405 Q-loop/lid; other site 632772010406 ABC transporter signature motif; other site 632772010407 Walker B; other site 632772010408 D-loop; other site 632772010409 H-loop/switch region; other site 632772010410 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 632772010411 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 632772010412 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 632772010413 TM-ABC transporter signature motif; other site 632772010414 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 632772010415 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 632772010416 TM-ABC transporter signature motif; other site 632772010417 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 632772010418 classical (c) SDRs; Region: SDR_c; cd05233 632772010419 NAD(P) binding site [chemical binding]; other site 632772010420 active site 632772010421 EthD domain; Region: EthD; cl17553 632772010422 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 632772010423 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 632772010424 SnoaL-like domain; Region: SnoaL_4; pfam13577 632772010425 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 632772010426 classical (c) SDRs; Region: SDR_c; cd05233 632772010427 NAD(P) binding site [chemical binding]; other site 632772010428 active site 632772010429 D-galactonate transporter; Region: 2A0114; TIGR00893 632772010430 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772010431 putative substrate translocation pore; other site 632772010432 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 632772010433 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 632772010434 NAD(P) binding site [chemical binding]; other site 632772010435 catalytic residues [active] 632772010436 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 632772010437 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 632772010438 active site 632772010439 FMN binding site [chemical binding]; other site 632772010440 substrate binding site [chemical binding]; other site 632772010441 homotetramer interface [polypeptide binding]; other site 632772010442 catalytic residue [active] 632772010443 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 632772010444 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772010445 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772010446 active site 632772010447 Protein of unknown function, DUF485; Region: DUF485; pfam04341 632772010448 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 632772010449 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 632772010450 Na binding site [ion binding]; other site 632772010451 EthD domain; Region: EthD; cl17553 632772010452 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 632772010453 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 632772010454 active site 632772010455 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 632772010456 catalytic triad [active] 632772010457 dimer interface [polypeptide binding]; other site 632772010458 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 632772010459 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 632772010460 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 632772010461 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 632772010462 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 632772010463 carboxyltransferase (CT) interaction site; other site 632772010464 biotinylation site [posttranslational modification]; other site 632772010465 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 632772010466 classical (c) SDRs; Region: SDR_c; cd05233 632772010467 NAD(P) binding site [chemical binding]; other site 632772010468 active site 632772010469 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 632772010470 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 632772010471 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 632772010472 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 632772010473 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772010474 NAD(P) binding site [chemical binding]; other site 632772010475 active site 632772010476 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 632772010477 classical (c) SDRs; Region: SDR_c; cd05233 632772010478 NAD(P) binding site [chemical binding]; other site 632772010479 active site 632772010480 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772010481 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772010482 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 632772010483 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772010484 acyl-activating enzyme (AAE) consensus motif; other site 632772010485 AMP binding site [chemical binding]; other site 632772010486 active site 632772010487 CoA binding site [chemical binding]; other site 632772010488 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 632772010489 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 632772010490 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772010491 dimer interface [polypeptide binding]; other site 632772010492 conserved gate region; other site 632772010493 ABC-ATPase subunit interface; other site 632772010494 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 632772010495 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 632772010496 Walker A/P-loop; other site 632772010497 ATP binding site [chemical binding]; other site 632772010498 Q-loop/lid; other site 632772010499 ABC transporter signature motif; other site 632772010500 Walker B; other site 632772010501 D-loop; other site 632772010502 H-loop/switch region; other site 632772010503 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 632772010504 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 632772010505 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 632772010506 active site 1 [active] 632772010507 dimer interface [polypeptide binding]; other site 632772010508 hexamer interface [polypeptide binding]; other site 632772010509 active site 2 [active] 632772010510 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 632772010511 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 632772010512 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 632772010513 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 632772010514 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 632772010515 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 632772010516 dimerization interface [polypeptide binding]; other site 632772010517 substrate binding pocket [chemical binding]; other site 632772010518 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 632772010519 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 632772010520 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 632772010521 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 632772010522 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 632772010523 dimerization interface [polypeptide binding]; other site 632772010524 substrate binding pocket [chemical binding]; other site 632772010525 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 632772010526 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 632772010527 putative NAD(P) binding site [chemical binding]; other site 632772010528 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 632772010529 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 632772010530 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772010531 putative substrate translocation pore; other site 632772010532 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 632772010533 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632772010534 active site 632772010535 dimerization interface [polypeptide binding]; other site 632772010536 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 632772010537 DNA binding site [nucleotide binding] 632772010538 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 632772010539 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 632772010540 dimer interface [polypeptide binding]; other site 632772010541 phosphorylation site [posttranslational modification] 632772010542 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632772010543 ATP binding site [chemical binding]; other site 632772010544 Mg2+ binding site [ion binding]; other site 632772010545 G-X-G motif; other site 632772010546 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 632772010547 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 632772010548 CoA-transferase family III; Region: CoA_transf_3; pfam02515 632772010549 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772010550 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772010551 active site 632772010552 LexA repressor; Validated; Region: PRK00215 632772010553 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 632772010554 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 632772010555 Catalytic site [active] 632772010556 Predicted ATPase [General function prediction only]; Region: COG3903 632772010557 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632772010558 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632772010559 DNA binding residues [nucleotide binding] 632772010560 dimerization interface [polypeptide binding]; other site 632772010561 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 632772010562 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 632772010563 DNA binding residues [nucleotide binding] 632772010564 YCII-related domain; Region: YCII; cl00999 632772010565 RibD C-terminal domain; Region: RibD_C; cl17279 632772010566 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 632772010567 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 632772010568 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 632772010569 P-loop; other site 632772010570 Magnesium ion binding site [ion binding]; other site 632772010571 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 632772010572 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 632772010573 Transcriptional regulator [Transcription]; Region: LysR; COG0583 632772010574 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 632772010575 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 632772010576 dimerization interface [polypeptide binding]; other site 632772010577 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 632772010578 classical (c) SDRs; Region: SDR_c; cd05233 632772010579 NAD(P) binding site [chemical binding]; other site 632772010580 active site 632772010581 benzoate transport; Region: 2A0115; TIGR00895 632772010582 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772010583 putative substrate translocation pore; other site 632772010584 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 632772010585 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 632772010586 [2Fe-2S] cluster binding site [ion binding]; other site 632772010587 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887 632772010588 putative alpha subunit interface [polypeptide binding]; other site 632772010589 putative active site [active] 632772010590 putative substrate binding site [chemical binding]; other site 632772010591 Fe binding site [ion binding]; other site 632772010592 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 632772010593 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 632772010594 NAD binding site [chemical binding]; other site 632772010595 catalytic residues [active] 632772010596 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772010597 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772010598 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 632772010599 Lipocalin-like domain; Region: Lipocalin_5; pfam13924 632772010600 lipid-transfer protein; Provisional; Region: PRK07855 632772010601 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 632772010602 active site 632772010603 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 632772010604 DUF35 OB-fold domain; Region: DUF35; pfam01796 632772010605 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 632772010606 classical (c) SDRs; Region: SDR_c; cd05233 632772010607 NAD(P) binding site [chemical binding]; other site 632772010608 active site 632772010609 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 632772010610 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 632772010611 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 632772010612 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 632772010613 Cupin domain; Region: Cupin_2; cl17218 632772010614 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 632772010615 Cytochrome P450; Region: p450; cl12078 632772010616 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772010617 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772010618 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 632772010619 anti sigma factor interaction site; other site 632772010620 regulatory phosphorylation site [posttranslational modification]; other site 632772010621 Transcription factor WhiB; Region: Whib; pfam02467 632772010622 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 632772010623 PAS domain; Region: PAS_9; pfam13426 632772010624 putative active site [active] 632772010625 heme pocket [chemical binding]; other site 632772010626 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 632772010627 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 632772010628 DNA binding residues [nucleotide binding] 632772010629 putative dimer interface [polypeptide binding]; other site 632772010630 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 632772010631 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 632772010632 putative dimer interface [polypeptide binding]; other site 632772010633 GAF domain; Region: GAF; cl17456 632772010634 ANTAR domain; Region: ANTAR; pfam03861 632772010635 Competence-damaged protein; Region: CinA; pfam02464 632772010636 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 632772010637 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 632772010638 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 632772010639 anti sigma factor interaction site; other site 632772010640 regulatory phosphorylation site [posttranslational modification]; other site 632772010641 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 632772010642 Gas vesicle protein; Region: Gas_vesicle; cl02954 632772010643 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 632772010644 putative hydrophobic ligand binding site [chemical binding]; other site 632772010645 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772010646 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772010647 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 632772010648 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 632772010649 NAD(P) binding site [chemical binding]; other site 632772010650 catalytic residues [active] 632772010651 Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703 632772010652 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 632772010653 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 632772010654 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 632772010655 hydroxyglutarate oxidase; Provisional; Region: PRK11728 632772010656 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772010657 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772010658 KIP1-like protein; Region: KIP1; pfam07765 632772010659 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 632772010660 classical (c) SDRs; Region: SDR_c; cd05233 632772010661 NAD(P) binding site [chemical binding]; other site 632772010662 active site 632772010663 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 632772010664 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 632772010665 active site 632772010666 SnoaL-like domain; Region: SnoaL_2; pfam12680 632772010667 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632772010668 Gas vesicle protein; Region: Gas_vesicle; cl02954 632772010669 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 632772010670 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 632772010671 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 632772010672 potential frameshift: common BLAST hit: gi|152992472|ref|YP_001358193.1| 5-oxoprolinase (ATP-hydrolysing) 632772010673 Amidohydrolase; Region: Amidohydro_2; pfam04909 632772010674 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 632772010675 RibD C-terminal domain; Region: RibD_C; cl17279 632772010676 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 632772010677 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 632772010678 thioester formation/cholesterol transfer; other site 632772010679 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 632772010680 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 632772010681 Walker A motif; other site 632772010682 Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306 632772010683 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 632772010684 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 632772010685 Walker A motif; other site 632772010686 ATP binding site [chemical binding]; other site 632772010687 Walker B motif; other site 632772010688 DNA binding loops [nucleotide binding] 632772010689 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 632772010690 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 632772010691 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 632772010692 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 632772010693 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 632772010694 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 632772010695 dimer interface [polypeptide binding]; other site 632772010696 ssDNA binding site [nucleotide binding]; other site 632772010697 tetramer (dimer of dimers) interface [polypeptide binding]; other site 632772010698 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 632772010699 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 632772010700 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 632772010701 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 632772010702 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 632772010703 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 632772010704 substrate binding pocket [chemical binding]; other site 632772010705 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 632772010706 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 632772010707 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 632772010708 Predicted ATPase [General function prediction only]; Region: COG3903 632772010709 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 632772010710 TPR motif; other site 632772010711 binding surface 632772010712 Tetratricopeptide repeat; Region: TPR_12; pfam13424 632772010713 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632772010714 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632772010715 DNA binding residues [nucleotide binding] 632772010716 dimerization interface [polypeptide binding]; other site 632772010717 Interferon-induced transmembrane protein; Region: CD225; pfam04505 632772010718 Predicted integral membrane protein [Function unknown]; Region: COG5650 632772010719 Transglycosylase; Region: Transgly; pfam00912 632772010720 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 632772010721 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 632772010722 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 632772010723 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 632772010724 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 632772010725 Predicted transcriptional regulators [Transcription]; Region: COG1695 632772010726 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 632772010727 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 632772010728 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 632772010729 Transglycosylase; Region: Transgly; pfam00912 632772010730 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 632772010731 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 632772010732 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 632772010733 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772010734 dimer interface [polypeptide binding]; other site 632772010735 conserved gate region; other site 632772010736 putative PBP binding loops; other site 632772010737 ABC-ATPase subunit interface; other site 632772010738 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772010739 dimer interface [polypeptide binding]; other site 632772010740 conserved gate region; other site 632772010741 putative PBP binding loops; other site 632772010742 ABC-ATPase subunit interface; other site 632772010743 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 632772010744 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 632772010745 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 632772010746 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 632772010747 Walker A/P-loop; other site 632772010748 ATP binding site [chemical binding]; other site 632772010749 Q-loop/lid; other site 632772010750 ABC transporter signature motif; other site 632772010751 Walker B; other site 632772010752 D-loop; other site 632772010753 H-loop/switch region; other site 632772010754 TOBE domain; Region: TOBE_2; pfam08402 632772010755 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 632772010756 putative dimer interface [polypeptide binding]; other site 632772010757 putative [2Fe-2S] cluster binding site [ion binding]; other site 632772010758 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 632772010759 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 632772010760 intersubunit interface [polypeptide binding]; other site 632772010761 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 632772010762 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 632772010763 Domain of unknown function (DUF385); Region: DUF385; cl04387 632772010764 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 632772010765 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 632772010766 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 632772010767 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 632772010768 dimer interface [polypeptide binding]; other site 632772010769 active site 632772010770 short chain dehydrogenase; Provisional; Region: PRK08278 632772010771 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772010772 NAD(P) binding site [chemical binding]; other site 632772010773 active site 632772010774 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 632772010775 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 632772010776 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 632772010777 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 632772010778 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 632772010779 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 632772010780 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772010781 acyl-activating enzyme (AAE) consensus motif; other site 632772010782 AMP binding site [chemical binding]; other site 632772010783 active site 632772010784 CoA binding site [chemical binding]; other site 632772010785 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 632772010786 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772010787 active site 632772010788 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772010789 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 632772010790 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 632772010791 substrate binding pocket [chemical binding]; other site 632772010792 membrane-bound complex binding site; other site 632772010793 hinge residues; other site 632772010794 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 632772010795 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772010796 dimer interface [polypeptide binding]; other site 632772010797 conserved gate region; other site 632772010798 putative PBP binding loops; other site 632772010799 ABC-ATPase subunit interface; other site 632772010800 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 632772010801 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 632772010802 Walker A/P-loop; other site 632772010803 ATP binding site [chemical binding]; other site 632772010804 Q-loop/lid; other site 632772010805 ABC transporter signature motif; other site 632772010806 Walker B; other site 632772010807 D-loop; other site 632772010808 H-loop/switch region; other site 632772010809 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 632772010810 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 632772010811 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 632772010812 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 632772010813 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 632772010814 putative active site [active] 632772010815 hypothetical protein; Provisional; Region: PRK05463 632772010816 benzoate transport; Region: 2A0115; TIGR00895 632772010817 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772010818 putative substrate translocation pore; other site 632772010819 Transcriptional regulators [Transcription]; Region: GntR; COG1802 632772010820 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772010821 DNA-binding site [nucleotide binding]; DNA binding site 632772010822 FCD domain; Region: FCD; pfam07729 632772010823 Transcriptional regulators [Transcription]; Region: FadR; COG2186 632772010824 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772010825 DNA-binding site [nucleotide binding]; DNA binding site 632772010826 FCD domain; Region: FCD; pfam07729 632772010827 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 632772010828 Cysteine-rich domain; Region: CCG; pfam02754 632772010829 Cysteine-rich domain; Region: CCG; pfam02754 632772010830 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 632772010831 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 632772010832 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 632772010833 Uncharacterized conserved protein [Function unknown]; Region: COG1556 632772010834 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 632772010835 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 632772010836 hypothetical protein; Provisional; Region: PRK07945 632772010837 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 632772010838 active site 632772010839 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 632772010840 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772010841 NADH(P)-binding; Region: NAD_binding_10; pfam13460 632772010842 NAD(P) binding site [chemical binding]; other site 632772010843 active site 632772010844 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 632772010845 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 632772010846 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 632772010847 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 632772010848 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 632772010849 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 632772010850 putative hydrophobic ligand binding site [chemical binding]; other site 632772010851 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 632772010852 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 632772010853 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 632772010854 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 632772010855 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 632772010856 catalytic loop [active] 632772010857 iron binding site [ion binding]; other site 632772010858 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 632772010859 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 632772010860 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 632772010861 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 632772010862 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 632772010863 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 632772010864 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 632772010865 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 632772010866 XdhC Rossmann domain; Region: XdhC_C; pfam13478 632772010867 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 632772010868 CoA-transferase family III; Region: CoA_transf_3; pfam02515 632772010869 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 632772010870 Amidase; Region: Amidase; cl11426 632772010871 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772010872 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632772010873 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 632772010874 dimer interface [polypeptide binding]; other site 632772010875 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 632772010876 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 632772010877 Amidohydrolase; Region: Amidohydro_2; pfam04909 632772010878 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 632772010879 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772010880 acyl-activating enzyme (AAE) consensus motif; other site 632772010881 AMP binding site [chemical binding]; other site 632772010882 active site 632772010883 CoA binding site [chemical binding]; other site 632772010884 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 632772010885 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 632772010886 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772010887 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632772010888 putative substrate translocation pore; other site 632772010889 SnoaL-like domain; Region: SnoaL_4; pfam13577 632772010890 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 632772010891 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 632772010892 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 632772010893 active site 632772010894 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 632772010895 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 632772010896 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 632772010897 putative active site [active] 632772010898 putative metal binding site [ion binding]; other site 632772010899 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 632772010900 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 632772010901 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772010902 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 632772010903 active site 632772010904 Transcriptional regulators [Transcription]; Region: FadR; COG2186 632772010905 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772010906 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772010907 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 632772010908 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 632772010909 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 632772010910 Part of AAA domain; Region: AAA_19; pfam13245 632772010911 Family description; Region: UvrD_C_2; pfam13538 632772010912 SnoaL-like domain; Region: SnoaL_4; pfam13577 632772010913 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 632772010914 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 632772010915 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 632772010916 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 632772010917 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 632772010918 catalytic loop [active] 632772010919 iron binding site [ion binding]; other site 632772010920 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 632772010921 Cytochrome P450; Region: p450; cl12078 632772010922 Transcriptional regulators [Transcription]; Region: GntR; COG1802 632772010923 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772010924 DNA-binding site [nucleotide binding]; DNA binding site 632772010925 FCD domain; Region: FCD; pfam07729 632772010926 benzoate transport; Region: 2A0115; TIGR00895 632772010927 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772010928 putative substrate translocation pore; other site 632772010929 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 632772010930 active site 632772010931 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 632772010932 Condensation domain; Region: Condensation; pfam00668 632772010933 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772010934 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 632772010935 acyl-activating enzyme (AAE) consensus motif; other site 632772010936 AMP binding site [chemical binding]; other site 632772010937 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772010938 Condensation domain; Region: Condensation; pfam00668 632772010939 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 632772010940 Condensation domain; Region: Condensation; pfam00668 632772010941 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772010942 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 632772010943 acyl-activating enzyme (AAE) consensus motif; other site 632772010944 AMP binding site [chemical binding]; other site 632772010945 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772010946 Condensation domain; Region: Condensation; pfam00668 632772010947 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 632772010948 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772010949 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772010950 acyl-activating enzyme (AAE) consensus motif; other site 632772010951 AMP binding site [chemical binding]; other site 632772010952 Condensation domain; Region: Condensation; pfam00668 632772010953 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 632772010954 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772010955 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772010956 acyl-activating enzyme (AAE) consensus motif; other site 632772010957 AMP binding site [chemical binding]; other site 632772010958 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772010959 peptide synthase; Provisional; Region: PRK12467 632772010960 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772010961 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772010962 acyl-activating enzyme (AAE) consensus motif; other site 632772010963 AMP binding site [chemical binding]; other site 632772010964 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772010965 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772010966 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772010967 acyl-activating enzyme (AAE) consensus motif; other site 632772010968 AMP binding site [chemical binding]; other site 632772010969 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772010970 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 632772010971 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772010972 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772010973 acyl-activating enzyme (AAE) consensus motif; other site 632772010974 AMP binding site [chemical binding]; other site 632772010975 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772010976 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 632772010977 Putative esterase; Region: Esterase; pfam00756 632772010978 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 632772010979 agmatinase; Region: agmatinase; TIGR01230 632772010980 oligomer interface [polypeptide binding]; other site 632772010981 putative active site [active] 632772010982 Mn binding site [ion binding]; other site 632772010983 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 632772010984 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 632772010985 non-specific DNA binding site [nucleotide binding]; other site 632772010986 salt bridge; other site 632772010987 sequence-specific DNA binding site [nucleotide binding]; other site 632772010988 Cupin domain; Region: Cupin_2; pfam07883 632772010989 amino acid transporter; Region: 2A0306; TIGR00909 632772010990 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 632772010991 Predicted amidohydrolase [General function prediction only]; Region: COG0388 632772010992 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 632772010993 putative active site [active] 632772010994 catalytic triad [active] 632772010995 putative dimer interface [polypeptide binding]; other site 632772010996 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 632772010997 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 632772010998 Alkaline and neutral invertase; Region: Glyco_hydro_100; cl17340 632772010999 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 632772011000 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 632772011001 amino acid transporter; Region: 2A0306; TIGR00909 632772011002 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 632772011003 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 632772011004 metal-binding site [ion binding] 632772011005 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 632772011006 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 632772011007 metal-binding site [ion binding] 632772011008 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 632772011009 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 632772011010 putative homodimer interface [polypeptide binding]; other site 632772011011 putative homotetramer interface [polypeptide binding]; other site 632772011012 putative allosteric switch controlling residues; other site 632772011013 putative metal binding site [ion binding]; other site 632772011014 putative homodimer-homodimer interface [polypeptide binding]; other site 632772011015 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 632772011016 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 632772011017 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632772011018 motif II; other site 632772011019 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 632772011020 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 632772011021 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 632772011022 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 632772011023 Transcriptional regulator [Transcription]; Region: LysR; COG0583 632772011024 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 632772011025 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 632772011026 putative dimerization interface [polypeptide binding]; other site 632772011027 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 632772011028 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 632772011029 hypothetical protein; Provisional; Region: PRK06541 632772011030 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 632772011031 inhibitor-cofactor binding pocket; inhibition site 632772011032 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632772011033 catalytic residue [active] 632772011034 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 632772011035 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 632772011036 hexamer interface [polypeptide binding]; other site 632772011037 ligand binding site [chemical binding]; other site 632772011038 putative active site [active] 632772011039 NAD(P) binding site [chemical binding]; other site 632772011040 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 632772011041 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772011042 DNA-binding site [nucleotide binding]; DNA binding site 632772011043 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 632772011044 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632772011045 homodimer interface [polypeptide binding]; other site 632772011046 catalytic residue [active] 632772011047 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 632772011048 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 632772011049 active site 632772011050 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 632772011051 Na binding site [ion binding]; other site 632772011052 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 632772011053 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 632772011054 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 632772011055 Transcriptional regulator [Transcription]; Region: IclR; COG1414 632772011056 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 632772011057 Bacterial transcriptional regulator; Region: IclR; pfam01614 632772011058 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 632772011059 Hydroxyacid-oxoacid transhydrogenase (HOT) involved in gamma-hydroxybutyrate metabolism; Region: HOT; cd08190 632772011060 putative active site [active] 632772011061 metal binding site [ion binding]; metal-binding site 632772011062 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772011063 metabolite-proton symporter; Region: 2A0106; TIGR00883 632772011064 putative substrate translocation pore; other site 632772011065 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 632772011066 sulfoacetaldehyde acetyltransferase; Validated; Region: PRK07525 632772011067 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 632772011068 PYR/PP interface [polypeptide binding]; other site 632772011069 dimer interface [polypeptide binding]; other site 632772011070 TPP binding site [chemical binding]; other site 632772011071 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 632772011072 Thiamine pyrophosphate (TPP) family, Xsc-like subfamily, TPP-binding module; composed of proteins similar to Alcaligenes defragrans sulfoacetaldehyde acetyltransferase (Xsc). Xsc plays a key role in the degradation of taurine, catalyzing the...; Region: TPP_Xsc_like; cd02013 632772011073 TPP-binding site; other site 632772011074 Transcriptional regulator [Transcription]; Region: IclR; COG1414 632772011075 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 632772011076 Bacterial transcriptional regulator; Region: IclR; pfam01614 632772011077 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 632772011078 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 632772011079 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 632772011080 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 632772011081 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 632772011082 metal ion-dependent adhesion site (MIDAS); other site 632772011083 phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351 632772011084 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632772011085 motif II; other site 632772011086 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 632772011087 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 632772011088 substrate binding pocket [chemical binding]; other site 632772011089 membrane-bound complex binding site; other site 632772011090 hinge residues; other site 632772011091 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 632772011092 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772011093 S-adenosylmethionine binding site [chemical binding]; other site 632772011094 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772011095 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772011096 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 632772011097 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296 632772011098 putative NAD(P) binding site [chemical binding]; other site 632772011099 putative substrate binding site [chemical binding]; other site 632772011100 catalytic Zn binding site [ion binding]; other site 632772011101 structural Zn binding site [ion binding]; other site 632772011102 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 632772011103 Transcriptional regulator [Transcription]; Region: IclR; COG1414 632772011104 Bacterial transcriptional regulator; Region: IclR; pfam01614 632772011105 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 632772011106 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 632772011107 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 632772011108 metal binding site [ion binding]; metal-binding site 632772011109 substrate binding pocket [chemical binding]; other site 632772011110 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 632772011111 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR9; cd08274 632772011112 putative NAD(P) binding site [chemical binding]; other site 632772011113 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 632772011114 potential frameshift: common BLAST hit: gi|118470665|ref|YP_886371.1| HpcE protein 632772011115 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 632772011116 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 632772011117 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 632772011118 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772011119 putative substrate translocation pore; other site 632772011120 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 632772011121 Transcriptional regulator [Transcription]; Region: IclR; COG1414 632772011122 Bacterial transcriptional regulator; Region: IclR; pfam01614 632772011123 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 632772011124 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 632772011125 dimer interface [polypeptide binding]; other site 632772011126 NADP binding site [chemical binding]; other site 632772011127 catalytic residues [active] 632772011128 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 632772011129 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 632772011130 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 632772011131 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 632772011132 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772011133 putative substrate translocation pore; other site 632772011134 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 632772011135 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 632772011136 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 632772011137 dimerization interface [polypeptide binding]; other site 632772011138 active site 632772011139 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 632772011140 Malic enzyme, N-terminal domain; Region: malic; pfam00390 632772011141 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 632772011142 NAD(P) binding pocket [chemical binding]; other site 632772011143 Transcription factor WhiB; Region: Whib; pfam02467 632772011144 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 632772011145 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 632772011146 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 632772011147 active site 632772011148 non-prolyl cis peptide bond; other site 632772011149 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 632772011150 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 632772011151 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 632772011152 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 632772011153 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 632772011154 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 632772011155 putative active site [active] 632772011156 putative FMN binding site [chemical binding]; other site 632772011157 putative substrate binding site [chemical binding]; other site 632772011158 putative catalytic residue [active] 632772011159 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 632772011160 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 632772011161 homotrimer interaction site [polypeptide binding]; other site 632772011162 putative active site [active] 632772011163 TAP-like protein; Region: Abhydrolase_4; pfam08386 632772011164 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 632772011165 classical (c) SDRs; Region: SDR_c; cd05233 632772011166 NAD(P) binding site [chemical binding]; other site 632772011167 active site 632772011168 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 632772011169 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 632772011170 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 632772011171 substrate binding pocket [chemical binding]; other site 632772011172 membrane-bound complex binding site; other site 632772011173 hinge residues; other site 632772011174 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 632772011175 Catalytic domain of Protein Kinases; Region: PKc; cd00180 632772011176 active site 632772011177 ATP binding site [chemical binding]; other site 632772011178 substrate binding site [chemical binding]; other site 632772011179 activation loop (A-loop); other site 632772011180 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 632772011181 ThiS interaction site; other site 632772011182 putative active site [active] 632772011183 tetramer interface [polypeptide binding]; other site 632772011184 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 632772011185 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 632772011186 Sulfatase; Region: Sulfatase; pfam00884 632772011187 hypothetical protein; Provisional; Region: PRK07945 632772011188 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 632772011189 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 632772011190 active site 632772011191 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 632772011192 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 632772011193 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 632772011194 dimerization interface [polypeptide binding]; other site 632772011195 Lysine efflux permease [General function prediction only]; Region: COG1279 632772011196 PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668 632772011197 short chain dehydrogenase; Provisional; Region: PRK08219 632772011198 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772011199 NAD(P) binding site [chemical binding]; other site 632772011200 active site 632772011201 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 632772011202 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 632772011203 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 632772011204 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 632772011205 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772011206 DNA-binding site [nucleotide binding]; DNA binding site 632772011207 UTRA domain; Region: UTRA; pfam07702 632772011208 phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351 632772011209 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632772011210 motif II; other site 632772011211 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 632772011212 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 632772011213 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 632772011214 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772011215 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772011216 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 632772011217 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772011218 substrate binding site [chemical binding]; other site 632772011219 oxyanion hole (OAH) forming residues; other site 632772011220 trimer interface [polypeptide binding]; other site 632772011221 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772011222 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 632772011223 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 632772011224 active site 632772011225 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 632772011226 CoA binding domain; Region: CoA_binding_2; pfam13380 632772011227 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 632772011228 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 632772011229 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 632772011230 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772011231 NAD(P) binding site [chemical binding]; other site 632772011232 active site 632772011233 TetR family transcriptional regulator; Provisional; Region: PRK14996 632772011234 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772011235 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 632772011236 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 632772011237 EamA-like transporter family; Region: EamA; pfam00892 632772011238 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 632772011239 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 632772011240 active site 632772011241 catalytic residues [active] 632772011242 metal binding site [ion binding]; metal-binding site 632772011243 DmpG-like communication domain; Region: DmpG_comm; pfam07836 632772011244 acetaldehyde dehydrogenase; Validated; Region: PRK08300 632772011245 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 632772011246 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 632772011247 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 632772011248 Transcriptional regulator [Transcription]; Region: IclR; COG1414 632772011249 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 632772011250 Bacterial transcriptional regulator; Region: IclR; pfam01614 632772011251 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 632772011252 RibD C-terminal domain; Region: RibD_C; cl17279 632772011253 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 632772011254 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 632772011255 active site 632772011256 catalytic tetrad [active] 632772011257 classical (c) SDRs; Region: SDR_c; cd05233 632772011258 NAD(P) binding site [chemical binding]; other site 632772011259 active site 632772011260 Protein of unknown function (DUF993); Region: DUF993; pfam06187 632772011261 Transcriptional regulators [Transcription]; Region: PurR; COG1609 632772011262 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 632772011263 DNA binding site [nucleotide binding] 632772011264 domain linker motif; other site 632772011265 potential protein location (hypothetical protein) that overlaps protein ( LacI family transcriptional regulator) 632772011266 potential protein location (hypothetical protein) that overlaps protein ( LacI family transcriptional regulator) 632772011267 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772011268 metabolite-proton symporter; Region: 2A0106; TIGR00883 632772011269 putative substrate translocation pore; other site 632772011270 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772011271 enoyl-CoA hydratase; Provisional; Region: PRK06688 632772011272 substrate binding site [chemical binding]; other site 632772011273 oxyanion hole (OAH) forming residues; other site 632772011274 trimer interface [polypeptide binding]; other site 632772011275 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 632772011276 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 632772011277 Coenzyme A transferase; Region: CoA_trans; smart00882 632772011278 Coenzyme A transferase; Region: CoA_trans; cl17247 632772011279 Transcriptional regulators [Transcription]; Region: PurR; COG1609 632772011280 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 632772011281 DNA binding site [nucleotide binding] 632772011282 domain linker motif; other site 632772011283 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 632772011284 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772011285 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772011286 FAD binding domain; Region: FAD_binding_3; pfam01494 632772011287 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 632772011288 hypothetical protein; Provisional; Region: PRK07236 632772011289 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 632772011290 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772011291 acyl-activating enzyme (AAE) consensus motif; other site 632772011292 AMP binding site [chemical binding]; other site 632772011293 active site 632772011294 CoA binding site [chemical binding]; other site 632772011295 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 632772011296 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 632772011297 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 632772011298 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 632772011299 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 632772011300 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 632772011301 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 632772011302 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 632772011303 Zn binding site [ion binding]; other site 632772011304 benzoate transport; Region: 2A0115; TIGR00895 632772011305 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772011306 putative substrate translocation pore; other site 632772011307 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 632772011308 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632772011309 motif II; other site 632772011310 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 632772011311 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 632772011312 HIGH motif; other site 632772011313 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 632772011314 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 632772011315 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 632772011316 active site 632772011317 KMSKS motif; other site 632772011318 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 632772011319 tRNA binding surface [nucleotide binding]; other site 632772011320 anticodon binding site; other site 632772011321 SdpI/YhfL protein family; Region: SdpI; pfam13630 632772011322 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 632772011323 Transcriptional regulators [Transcription]; Region: FadR; COG2186 632772011324 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772011325 DNA-binding site [nucleotide binding]; DNA binding site 632772011326 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 632772011327 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772011328 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632772011329 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 632772011330 Uncharacterized conserved protein [Function unknown]; Region: COG1656 632772011331 Protein of unknown function DUF82; Region: DUF82; pfam01927 632772011332 hypothetical protein; Validated; Region: PRK00228 632772011333 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772011334 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772011335 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 632772011336 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772011337 NAD(P) binding site [chemical binding]; other site 632772011338 active site 632772011339 H+ Antiporter protein; Region: 2A0121; TIGR00900 632772011340 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 632772011341 CoenzymeA binding site [chemical binding]; other site 632772011342 subunit interaction site [polypeptide binding]; other site 632772011343 PHB binding site; other site 632772011344 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 632772011345 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 632772011346 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632772011347 Walker A/P-loop; other site 632772011348 ATP binding site [chemical binding]; other site 632772011349 Q-loop/lid; other site 632772011350 ABC transporter signature motif; other site 632772011351 Walker B; other site 632772011352 D-loop; other site 632772011353 H-loop/switch region; other site 632772011354 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 632772011355 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 632772011356 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772011357 putative PBP binding loops; other site 632772011358 ABC-ATPase subunit interface; other site 632772011359 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 632772011360 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 632772011361 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 632772011362 DNA binding residues [nucleotide binding] 632772011363 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 632772011364 TOBE domain; Region: TOBE; cl01440 632772011365 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 632772011366 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 632772011367 [4Fe-4S] binding site [ion binding]; other site 632772011368 molybdopterin cofactor binding site; other site 632772011369 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 632772011370 molybdopterin cofactor binding site; other site 632772011371 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 632772011372 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 632772011373 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 632772011374 FAD binding pocket [chemical binding]; other site 632772011375 FAD binding motif [chemical binding]; other site 632772011376 catalytic residues [active] 632772011377 NAD binding pocket [chemical binding]; other site 632772011378 phosphate binding motif [ion binding]; other site 632772011379 beta-alpha-beta structure motif; other site 632772011380 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 632772011381 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 632772011382 active site 632772011383 NTP binding site [chemical binding]; other site 632772011384 metal binding triad [ion binding]; metal-binding site 632772011385 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 632772011386 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 632772011387 Zn2+ binding site [ion binding]; other site 632772011388 Mg2+ binding site [ion binding]; other site 632772011389 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 632772011390 active site 632772011391 Ap6A binding site [chemical binding]; other site 632772011392 nudix motif; other site 632772011393 metal binding site [ion binding]; metal-binding site 632772011394 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 632772011395 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 632772011396 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 632772011397 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632772011398 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 632772011399 DNA binding residues [nucleotide binding] 632772011400 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772011401 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772011402 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 632772011403 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772011404 NAD(P) binding site [chemical binding]; other site 632772011405 active site 632772011406 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 632772011407 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 632772011408 active site 632772011409 FMN binding site [chemical binding]; other site 632772011410 substrate binding site [chemical binding]; other site 632772011411 putative catalytic residue [active] 632772011412 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 632772011413 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 632772011414 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 632772011415 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 632772011416 catalytic residues [active] 632772011417 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 632772011418 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 632772011419 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 632772011420 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 632772011421 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 632772011422 active site 632772011423 metal binding site [ion binding]; metal-binding site 632772011424 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 632772011425 ParB-like nuclease domain; Region: ParBc; pfam02195 632772011426 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 632772011427 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 632772011428 P-loop; other site 632772011429 Magnesium ion binding site [ion binding]; other site 632772011430 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 632772011431 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 632772011432 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 632772011433 SnoaL-like domain; Region: SnoaL_3; pfam13474 632772011434 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 632772011435 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 632772011436 G-X-X-G motif; other site 632772011437 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 632772011438 RxxxH motif; other site 632772011439 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 632772011440 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 632772011441 hypothetical protein; Validated; Region: PRK00041 632772011442 ribonuclease P; Reviewed; Region: rnpA; PRK03459 632772011443 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 632772011444 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632772011445 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 632772011446 Walker A motif; other site 632772011447 ATP binding site [chemical binding]; other site 632772011448 Walker B motif; other site 632772011449 arginine finger; other site 632772011450 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 632772011451 DnaA box-binding interface [nucleotide binding]; other site 632772011452 DNA polymerase III subunit beta; Validated; Region: PRK07761 632772011453 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 632772011454 putative DNA binding surface [nucleotide binding]; other site 632772011455 dimer interface [polypeptide binding]; other site 632772011456 beta-clamp/clamp loader binding surface; other site 632772011457 beta-clamp/translesion DNA polymerase binding surface; other site 632772011458 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 632772011459 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 632772011460 recombination protein F; Reviewed; Region: recF; PRK00064 632772011461 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 632772011462 Walker A/P-loop; other site 632772011463 ATP binding site [chemical binding]; other site 632772011464 Q-loop/lid; other site 632772011465 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632772011466 ABC transporter signature motif; other site 632772011467 Walker B; other site 632772011468 D-loop; other site 632772011469 H-loop/switch region; other site 632772011470 hypothetical protein; Provisional; Region: PRK03195 632772011471 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 632772011472 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 632772011473 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 632772011474 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 632772011475 FMN-binding pocket [chemical binding]; other site 632772011476 flavin binding motif; other site 632772011477 phosphate binding motif [ion binding]; other site 632772011478 beta-alpha-beta structure motif; other site 632772011479 NAD binding pocket [chemical binding]; other site 632772011480 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 632772011481 catalytic loop [active] 632772011482 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 632772011483 iron binding site [ion binding]; other site 632772011484 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 632772011485 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 632772011486 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632772011487 ATP binding site [chemical binding]; other site 632772011488 Mg2+ binding site [ion binding]; other site 632772011489 G-X-G motif; other site 632772011490 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 632772011491 anchoring element; other site 632772011492 dimer interface [polypeptide binding]; other site 632772011493 ATP binding site [chemical binding]; other site 632772011494 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 632772011495 active site 632772011496 putative metal-binding site [ion binding]; other site 632772011497 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 632772011498 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 632772011499 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632772011500 ATP binding site [chemical binding]; other site 632772011501 Mg2+ binding site [ion binding]; other site 632772011502 G-X-G motif; other site 632772011503 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 632772011504 Protein of unknown function (DUF742); Region: DUF742; pfam05331 632772011505 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 632772011506 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 632772011507 G1 box; other site 632772011508 GTP/Mg2+ binding site [chemical binding]; other site 632772011509 G2 box; other site 632772011510 Switch I region; other site 632772011511 G3 box; other site 632772011512 Switch II region; other site 632772011513 G4 box; other site 632772011514 G5 box; other site 632772011515 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 632772011516 DNA gyrase subunit A; Validated; Region: PRK05560 632772011517 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 632772011518 CAP-like domain; other site 632772011519 active site 632772011520 primary dimer interface [polypeptide binding]; other site 632772011521 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 632772011522 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 632772011523 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 632772011524 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 632772011525 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 632772011526 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 632772011527 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 632772011528 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 632772011529 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 632772011530 FAD binding pocket [chemical binding]; other site 632772011531 FAD binding motif [chemical binding]; other site 632772011532 phosphate binding motif [ion binding]; other site 632772011533 NAD binding pocket [chemical binding]; other site 632772011534 chorismate mutase; Provisional; Region: PRK09269 632772011535 Chorismate mutase type II; Region: CM_2; cl00693 632772011536 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 632772011537 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 632772011538 conserved cys residue [active] 632772011539 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632772011540 Predicted membrane protein [Function unknown]; Region: COG4425 632772011541 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 632772011542 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 632772011543 active site 632772011544 B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; Region: BBOX; cl00034 632772011545 Rhomboid family; Region: Rhomboid; pfam01694 632772011546 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 632772011547 putative septation inhibitor protein; Reviewed; Region: PRK00159 632772011548 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 632772011549 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 632772011550 Glutamine amidotransferase class-I; Region: GATase; pfam00117 632772011551 glutamine binding [chemical binding]; other site 632772011552 catalytic triad [active] 632772011553 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 632772011554 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 632772011555 active site 632772011556 ATP binding site [chemical binding]; other site 632772011557 substrate binding site [chemical binding]; other site 632772011558 activation loop (A-loop); other site 632772011559 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 632772011560 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 632772011561 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 632772011562 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 632772011563 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 632772011564 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 632772011565 Catalytic domain of Protein Kinases; Region: PKc; cd00180 632772011566 active site 632772011567 ATP binding site [chemical binding]; other site 632772011568 substrate binding site [chemical binding]; other site 632772011569 activation loop (A-loop); other site 632772011570 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 632772011571 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 632772011572 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 632772011573 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 632772011574 active site 632772011575 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 632772011576 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 632772011577 phosphopeptide binding site; other site 632772011578 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 632772011579 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 632772011580 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 632772011581 phosphopeptide binding site; other site 632772011582 RDD family; Region: RDD; pfam06271 632772011583 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632772011584 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 632772011585 Mitomycin C resistance protein (MRD); Region: MRD; cd07235 632772011586 dimer interface [polypeptide binding]; other site 632772011587 ligand binding site [chemical binding]; other site 632772011588 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 632772011589 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 632772011590 potential frameshift: common BLAST hit: gi|29826561|ref|NP_821195.1| Rhs protein 632772011591 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 632772011592 RHS Repeat; Region: RHS_repeat; cl11982 632772011593 RHS Repeat; Region: RHS_repeat; pfam05593 632772011594 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 632772011595 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 632772011596 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 632772011597 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772011598 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 632772011599 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 632772011600 active site 632772011601 dimer interface [polypeptide binding]; other site 632772011602 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 632772011603 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 632772011604 active site 632772011605 FMN binding site [chemical binding]; other site 632772011606 substrate binding site [chemical binding]; other site 632772011607 3Fe-4S cluster binding site [ion binding]; other site 632772011608 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 632772011609 domain interface; other site 632772011610 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 632772011611 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 632772011612 Cutinase; Region: Cutinase; pfam01083 632772011613 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 632772011614 active site 632772011615 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 632772011616 hydrophobic ligand binding site; other site 632772011617 short chain dehydrogenase; Provisional; Region: PRK06181 632772011618 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772011619 NAD(P) binding site [chemical binding]; other site 632772011620 active site 632772011621 short chain dehydrogenase; Provisional; Region: PRK07832 632772011622 classical (c) SDRs; Region: SDR_c; cd05233 632772011623 NAD(P) binding site [chemical binding]; other site 632772011624 active site 632772011625 Uncharacterized conserved protein [Function unknown]; Region: COG1359 632772011626 Dienelactone hydrolase family; Region: DLH; pfam01738 632772011627 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 632772011628 nucleotide binding site [chemical binding]; other site 632772011629 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 632772011630 nucleotide binding site [chemical binding]; other site 632772011631 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 632772011632 catalytic core [active] 632772011633 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 632772011634 Protein of unknown function (DUF998); Region: DUF998; pfam06197 632772011635 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 632772011636 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 632772011637 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 632772011638 dimer interface [polypeptide binding]; other site 632772011639 putative anticodon binding site; other site 632772011640 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 632772011641 motif 1; other site 632772011642 dimer interface [polypeptide binding]; other site 632772011643 active site 632772011644 motif 2; other site 632772011645 motif 3; other site 632772011646 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 632772011647 RNA binding surface [nucleotide binding]; other site 632772011648 hypothetical protein; Provisional; Region: PRK07907 632772011649 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 632772011650 active site 632772011651 metal binding site [ion binding]; metal-binding site 632772011652 dimer interface [polypeptide binding]; other site 632772011653 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 632772011654 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 632772011655 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 632772011656 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 632772011657 NADP binding site [chemical binding]; other site 632772011658 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772011659 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772011660 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 632772011661 Transcriptional regulator [Transcription]; Region: IclR; COG1414 632772011662 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 632772011663 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 632772011664 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 632772011665 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 632772011666 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 632772011667 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 632772011668 carboxyltransferase (CT) interaction site; other site 632772011669 biotinylation site [posttranslational modification]; other site 632772011670 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 632772011671 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 632772011672 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 632772011673 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 632772011674 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 632772011675 DNA binding residues [nucleotide binding] 632772011676 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 632772011677 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 632772011678 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 632772011679 acyl-activating enzyme (AAE) consensus motif; other site 632772011680 putative AMP binding site [chemical binding]; other site 632772011681 putative active site [active] 632772011682 putative CoA binding site [chemical binding]; other site 632772011683 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772011684 putative substrate translocation pore; other site 632772011685 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 632772011686 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772011687 Protein of unknown function (DUF2716); Region: DUF2716; pfam10898 632772011688 choline dehydrogenase; Validated; Region: PRK02106 632772011689 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 632772011690 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 632772011691 active site 632772011692 motif 2; other site 632772011693 motif 3; other site 632772011694 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 632772011695 Na binding site [ion binding]; other site 632772011696 Transposase, Mutator family; Region: Transposase_mut; pfam00872 632772011697 MULE transposase domain; Region: MULE; pfam10551 632772011698 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 632772011699 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 632772011700 active site 632772011701 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 632772011702 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 632772011703 Protein of unknown function (DUF1188); Region: DUF1188; cl01642 632772011704 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 632772011705 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 632772011706 catalytic residues [active] 632772011707 catalytic nucleophile [active] 632772011708 Presynaptic Site I dimer interface [polypeptide binding]; other site 632772011709 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 632772011710 Synaptic Flat tetramer interface [polypeptide binding]; other site 632772011711 Synaptic Site I dimer interface [polypeptide binding]; other site 632772011712 DNA binding site [nucleotide binding] 632772011713 potential frameshift: common BLAST hit: gi|111025307|ref|YP_707727.1| site-specific DNA recombinase/resolvase 632772011714 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 632772011715 Phosphotransferase enzyme family; Region: APH; pfam01636 632772011716 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 632772011717 active site 632772011718 substrate binding site [chemical binding]; other site 632772011719 ATP binding site [chemical binding]; other site 632772011720 potential frameshift: common BLAST hit: gi|134102833|ref|YP_001108494.1| protein of unknown function DUF899,thioredoxin-like 632772011721 Bacterial protein of unknown function (DUF899); Region: DUF899; cl17828 632772011722 Bacterial protein of unknown function (DUF899); Region: DUF899; cl17828 632772011723 HicB family; Region: HicB; pfam05534 632772011724 Protein of unknown function (DUF2716); Region: DUF2716; pfam10898 632772011725 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 632772011726 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 632772011727 E3 interaction surface; other site 632772011728 lipoyl attachment site [posttranslational modification]; other site 632772011729 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 632772011730 Pyruvate dehydrogenase complex, dehydrogenase (E1) component [Energy production and conversion]; Region: AceE; COG2609 632772011731 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 632772011732 TPP-binding site [chemical binding]; other site 632772011733 PYR/PP interface [polypeptide binding]; other site 632772011734 dimer interface [polypeptide binding]; other site 632772011735 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 632772011736 TPP binding site [chemical binding]; other site 632772011737 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 632772011738 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 632772011739 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632772011740 putative DNA binding site [nucleotide binding]; other site 632772011741 putative Zn2+ binding site [ion binding]; other site 632772011742 AsnC family; Region: AsnC_trans_reg; pfam01037 632772011743 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 632772011744 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 632772011745 PYR/PP interface [polypeptide binding]; other site 632772011746 dimer interface [polypeptide binding]; other site 632772011747 TPP binding site [chemical binding]; other site 632772011748 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 632772011749 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 632772011750 TPP-binding site [chemical binding]; other site 632772011751 dimer interface [polypeptide binding]; other site 632772011752 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 632772011753 active site 632772011754 NTP binding site [chemical binding]; other site 632772011755 metal binding triad [ion binding]; metal-binding site 632772011756 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 632772011757 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 632772011758 conserved cys residue [active] 632772011759 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632772011760 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632772011761 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 632772011762 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 632772011763 Sulfate transporter family; Region: Sulfate_transp; pfam00916 632772011764 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 632772011765 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 632772011766 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 632772011767 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 632772011768 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 632772011769 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632772011770 motif II; other site 632772011771 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 632772011772 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 632772011773 Short C-terminal domain; Region: SHOCT; pfam09851 632772011774 Short C-terminal domain; Region: SHOCT; pfam09851 632772011775 Predicted membrane protein [Function unknown]; Region: COG4425 632772011776 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 632772011777 poly(3-hydroxyalkanoate) depolymerase; Region: PHA_depoly_arom; TIGR02240 632772011778 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 632772011779 putative active site [active] 632772011780 putative catalytic site [active] 632772011781 poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839 632772011782 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 632772011783 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 632772011784 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 632772011785 acyl-activating enzyme (AAE) consensus motif; other site 632772011786 putative AMP binding site [chemical binding]; other site 632772011787 putative active site [active] 632772011788 putative CoA binding site [chemical binding]; other site 632772011789 Serine hydrolase; Region: Ser_hydrolase; pfam06821 632772011790 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 632772011791 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772011792 putative substrate translocation pore; other site 632772011793 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 632772011794 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 632772011795 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 632772011796 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 632772011797 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 632772011798 NADP binding site [chemical binding]; other site 632772011799 dimer interface [polypeptide binding]; other site 632772011800 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 632772011801 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 632772011802 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632772011803 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 632772011804 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 632772011805 putative active site [active] 632772011806 putative dimer interface [polypeptide binding]; other site 632772011807 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 632772011808 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 632772011809 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 632772011810 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 632772011811 Coenzyme A binding pocket [chemical binding]; other site 632772011812 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 632772011813 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772011814 putative substrate translocation pore; other site 632772011815 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 632772011816 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 632772011817 dimer interface [polypeptide binding]; other site 632772011818 NADP binding site [chemical binding]; other site 632772011819 catalytic residues [active] 632772011820 5-dehydro-4-deoxyglucarate dehydratase; Provisional; Region: PRK03620 632772011821 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 632772011822 catalytic residue [active] 632772011823 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 632772011824 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 632772011825 active site 632772011826 tetramer interface [polypeptide binding]; other site 632772011827 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 632772011828 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 632772011829 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447 632772011830 putative dimerization interface [polypeptide binding]; other site 632772011831 putative substrate binding pocket [chemical binding]; other site 632772011832 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 632772011833 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 632772011834 putative FMN binding site [chemical binding]; other site 632772011835 Predicted transcriptional regulators [Transcription]; Region: COG1733 632772011836 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 632772011837 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 632772011838 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 632772011839 Beta-lactamase; Region: Beta-lactamase; pfam00144 632772011840 Homeodomain-like domain; Region: HTH_23; pfam13384 632772011841 Winged helix-turn helix; Region: HTH_29; pfam13551 632772011842 Homeodomain-like domain; Region: HTH_32; pfam13565 632772011843 Transcriptional regulators [Transcription]; Region: FadR; COG2186 632772011844 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772011845 DNA-binding site [nucleotide binding]; DNA binding site 632772011846 FCD domain; Region: FCD; pfam07729 632772011847 benzoate transport; Region: 2A0115; TIGR00895 632772011848 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772011849 putative substrate translocation pore; other site 632772011850 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772011851 RibD C-terminal domain; Region: RibD_C; cl17279 632772011852 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 632772011853 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 632772011854 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 632772011855 Sulfatase; Region: Sulfatase; pfam00884 632772011856 Sulfatase; Region: Sulfatase; cl17466 632772011857 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 632772011858 Catalytic domain of Protein Kinases; Region: PKc; cd00180 632772011859 active site 632772011860 ATP binding site [chemical binding]; other site 632772011861 substrate binding site [chemical binding]; other site 632772011862 activation loop (A-loop); other site 632772011863 Predicted ATPase [General function prediction only]; Region: COG3903 632772011864 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632772011865 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632772011866 DNA binding residues [nucleotide binding] 632772011867 dimerization interface [polypeptide binding]; other site 632772011868 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 632772011869 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 632772011870 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 632772011871 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 632772011872 active site 2 [active] 632772011873 active site 1 [active] 632772011874 FAD dependent oxidoreductase; Region: DAO; pfam01266 632772011875 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 632772011876 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 632772011877 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 632772011878 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 632772011879 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 632772011880 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 632772011881 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 632772011882 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 632772011883 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 632772011884 PAS fold; Region: PAS_3; pfam08447 632772011885 putative active site [active] 632772011886 heme pocket [chemical binding]; other site 632772011887 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 632772011888 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 632772011889 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 632772011890 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 632772011891 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 632772011892 heme binding pocket [chemical binding]; other site 632772011893 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 632772011894 domain interactions; other site 632772011895 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 632772011896 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 632772011897 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 632772011898 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 632772011899 SnoaL-like domain; Region: SnoaL_3; pfam13474 632772011900 guanine deaminase; Provisional; Region: PRK09228 632772011901 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 632772011902 active site 632772011903 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 632772011904 Cytochrome P450; Region: p450; cl12078 632772011905 Methyltransferase domain; Region: Methyltransf_31; pfam13847 632772011906 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772011907 S-adenosylmethionine binding site [chemical binding]; other site 632772011908 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 632772011909 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 632772011910 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 632772011911 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 632772011912 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 632772011913 active site 632772011914 metal binding site [ion binding]; metal-binding site 632772011915 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 632772011916 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772011917 dimer interface [polypeptide binding]; other site 632772011918 conserved gate region; other site 632772011919 putative PBP binding loops; other site 632772011920 ABC-ATPase subunit interface; other site 632772011921 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 632772011922 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772011923 dimer interface [polypeptide binding]; other site 632772011924 conserved gate region; other site 632772011925 putative PBP binding loops; other site 632772011926 ABC-ATPase subunit interface; other site 632772011927 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 632772011928 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 632772011929 active site 632772011930 metal binding site [ion binding]; metal-binding site 632772011931 hexamer interface [polypeptide binding]; other site 632772011932 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 632772011933 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 632772011934 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 632772011935 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 632772011936 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 632772011937 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 632772011938 Walker A/P-loop; other site 632772011939 ATP binding site [chemical binding]; other site 632772011940 Q-loop/lid; other site 632772011941 ABC transporter signature motif; other site 632772011942 Walker B; other site 632772011943 D-loop; other site 632772011944 H-loop/switch region; other site 632772011945 TOBE domain; Region: TOBE_2; pfam08402 632772011946 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 632772011947 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 632772011948 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 632772011949 putative active site [active] 632772011950 Putative zinc-finger; Region: zf-HC2; pfam13490 632772011951 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 632772011952 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632772011953 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 632772011954 DNA binding residues [nucleotide binding] 632772011955 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 632772011956 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632772011957 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 632772011958 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 632772011959 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 632772011960 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632772011961 Walker A/P-loop; other site 632772011962 ATP binding site [chemical binding]; other site 632772011963 Q-loop/lid; other site 632772011964 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632772011965 ABC transporter signature motif; other site 632772011966 Walker B; other site 632772011967 D-loop; other site 632772011968 H-loop/switch region; other site 632772011969 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632772011970 Walker A/P-loop; other site 632772011971 ATP binding site [chemical binding]; other site 632772011972 Q-loop/lid; other site 632772011973 ABC transporter signature motif; other site 632772011974 Walker B; other site 632772011975 D-loop; other site 632772011976 H-loop/switch region; other site 632772011977 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 632772011978 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632772011979 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 632772011980 DNA binding residues [nucleotide binding] 632772011981 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 632772011982 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 632772011983 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772011984 NAD(P) binding site [chemical binding]; other site 632772011985 active site 632772011986 metabolite-proton symporter; Region: 2A0106; TIGR00883 632772011987 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772011988 putative substrate translocation pore; other site 632772011989 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 632772011990 TPP-binding site [chemical binding]; other site 632772011991 dimer interface [polypeptide binding]; other site 632772011992 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 632772011993 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 632772011994 PYR/PP interface [polypeptide binding]; other site 632772011995 dimer interface [polypeptide binding]; other site 632772011996 TPP binding site [chemical binding]; other site 632772011997 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 632772011998 Transcriptional regulators [Transcription]; Region: GntR; COG1802 632772011999 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772012000 DNA-binding site [nucleotide binding]; DNA binding site 632772012001 FCD domain; Region: FCD; pfam07729 632772012002 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 632772012003 active site 632772012004 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 632772012005 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 632772012006 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 632772012007 Na binding site [ion binding]; other site 632772012008 Transcriptional regulators [Transcription]; Region: PurR; COG1609 632772012009 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 632772012010 DNA binding site [nucleotide binding] 632772012011 domain linker motif; other site 632772012012 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 632772012013 ligand binding site [chemical binding]; other site 632772012014 dimerization interface [polypeptide binding]; other site 632772012015 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 632772012016 Catalytic domain of Protein Kinases; Region: PKc; cd00180 632772012017 active site 632772012018 ATP binding site [chemical binding]; other site 632772012019 substrate binding site [chemical binding]; other site 632772012020 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 632772012021 activation loop (A-loop); other site 632772012022 AAA ATPase domain; Region: AAA_16; pfam13191 632772012023 Predicted ATPase [General function prediction only]; Region: COG3903 632772012024 Tetratricopeptide repeat; Region: TPR_12; pfam13424 632772012025 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632772012026 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632772012027 DNA binding residues [nucleotide binding] 632772012028 dimerization interface [polypeptide binding]; other site 632772012029 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 632772012030 Amidohydrolase; Region: Amidohydro_2; pfam04909 632772012031 active site 632772012032 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 632772012033 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 632772012034 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 632772012035 PYR/PP interface [polypeptide binding]; other site 632772012036 dimer interface [polypeptide binding]; other site 632772012037 TPP binding site [chemical binding]; other site 632772012038 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 632772012039 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 632772012040 TPP-binding site [chemical binding]; other site 632772012041 Amidohydrolase; Region: Amidohydro_2; pfam04909 632772012042 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 632772012043 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 632772012044 putative hydrophobic ligand binding site [chemical binding]; other site 632772012045 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 632772012046 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 632772012047 Amidohydrolase; Region: Amidohydro_2; pfam04909 632772012048 active site 632772012049 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 632772012050 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 632772012051 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 632772012052 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 632772012053 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 632772012054 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 632772012055 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772012056 dimer interface [polypeptide binding]; other site 632772012057 conserved gate region; other site 632772012058 putative PBP binding loops; other site 632772012059 ABC-ATPase subunit interface; other site 632772012060 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 632772012061 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632772012062 Walker A/P-loop; other site 632772012063 ATP binding site [chemical binding]; other site 632772012064 Q-loop/lid; other site 632772012065 ABC transporter signature motif; other site 632772012066 Walker B; other site 632772012067 D-loop; other site 632772012068 H-loop/switch region; other site 632772012069 TOBE domain; Region: TOBE_2; pfam08402 632772012070 hypothetical protein; Provisional; Region: PRK06834 632772012071 TrkA-N domain; Region: TrkA_N; pfam02254 632772012072 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 632772012073 Transcriptional regulators [Transcription]; Region: GntR; COG1802 632772012074 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772012075 DNA-binding site [nucleotide binding]; DNA binding site 632772012076 FCD domain; Region: FCD; pfam07729 632772012077 N-terminal, non-catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_N_like; cd09013 632772012078 tetramer interface [polypeptide binding]; other site 632772012079 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 632772012080 C-terminal, catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_C_like; cd09014 632772012081 tetramer interface [polypeptide binding]; other site 632772012082 active site 632772012083 metal binding site [ion binding]; metal-binding site 632772012084 acetaldehyde dehydrogenase; Validated; Region: PRK08300 632772012085 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 632772012086 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 632772012087 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 632772012088 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 632772012089 active site 632772012090 catalytic residues [active] 632772012091 metal binding site [ion binding]; metal-binding site 632772012092 DmpG-like communication domain; Region: DmpG_comm; pfam07836 632772012093 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 632772012094 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 632772012095 NAD binding site [chemical binding]; other site 632772012096 catalytic residues [active] 632772012097 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 632772012098 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772012099 NAD(P) binding site [chemical binding]; other site 632772012100 active site 632772012101 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 632772012102 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 632772012103 hexamer interface [polypeptide binding]; other site 632772012104 active site 2 [active] 632772012105 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 632772012106 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 632772012107 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 632772012108 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 632772012109 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632772012110 Domain of unknown function (DUF222); Region: DUF222; pfam02720 632772012111 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 632772012112 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 632772012113 catalytic loop [active] 632772012114 iron binding site [ion binding]; other site 632772012115 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 632772012116 FAD binding pocket [chemical binding]; other site 632772012117 FAD binding motif [chemical binding]; other site 632772012118 phosphate binding motif [ion binding]; other site 632772012119 beta-alpha-beta structure motif; other site 632772012120 NAD binding pocket [chemical binding]; other site 632772012121 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 632772012122 Cytochrome P450; Region: p450; cl12078 632772012123 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 632772012124 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632772012125 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772012126 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772012127 active site 632772012128 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 632772012129 active site 1 [active] 632772012130 dimer interface [polypeptide binding]; other site 632772012131 hexamer interface [polypeptide binding]; other site 632772012132 active site 2 [active] 632772012133 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 632772012134 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 632772012135 Transcriptional regulator [Transcription]; Region: IclR; COG1414 632772012136 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 632772012137 Bacterial transcriptional regulator; Region: IclR; pfam01614 632772012138 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772012139 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 632772012140 acyl-activating enzyme (AAE) consensus motif; other site 632772012141 AMP binding site [chemical binding]; other site 632772012142 active site 632772012143 CoA binding site [chemical binding]; other site 632772012144 potential frameshift: common BLAST hit: gi|134102513|ref|YP_001108174.1| fructose transport system kinase 632772012145 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 632772012146 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 632772012147 active site 632772012148 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 632772012149 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 632772012150 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 632772012151 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 632772012152 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 632772012153 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 632772012154 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 632772012155 Transcriptional regulators [Transcription]; Region: PurR; COG1609 632772012156 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 632772012157 DNA binding site [nucleotide binding] 632772012158 domain linker motif; other site 632772012159 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 632772012160 dimerization interface [polypeptide binding]; other site 632772012161 ligand binding site [chemical binding]; other site 632772012162 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 632772012163 Ligand Binding Site [chemical binding]; other site 632772012164 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 632772012165 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772012166 putative substrate translocation pore; other site 632772012167 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772012168 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772012169 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772012170 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 632772012171 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772012172 substrate binding site [chemical binding]; other site 632772012173 oxyanion hole (OAH) forming residues; other site 632772012174 trimer interface [polypeptide binding]; other site 632772012175 putative acyltransferase; Provisional; Region: PRK05790 632772012176 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 632772012177 dimer interface [polypeptide binding]; other site 632772012178 active site 632772012179 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 632772012180 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 632772012181 Transcriptional regulator [Transcription]; Region: IclR; COG1414 632772012182 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 632772012183 Bacterial transcriptional regulator; Region: IclR; pfam01614 632772012184 YceI-like domain; Region: YceI; smart00867 632772012185 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 632772012186 Uncharacterized conserved protein [Function unknown]; Region: COG2128 632772012187 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 632772012188 MarR family; Region: MarR; pfam01047 632772012189 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 632772012190 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 632772012191 Zn binding site [ion binding]; other site 632772012192 Pirin-related protein [General function prediction only]; Region: COG1741 632772012193 Pirin; Region: Pirin; pfam02678 632772012194 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 632772012195 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 632772012196 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 632772012197 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 632772012198 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 632772012199 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 632772012200 putative active site [active] 632772012201 Transcriptional regulator [Transcription]; Region: LysR; COG0583 632772012202 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 632772012203 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 632772012204 putative dimerization interface [polypeptide binding]; other site 632772012205 EamA-like transporter family; Region: EamA; pfam00892 632772012206 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 632772012207 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 632772012208 metal binding site [ion binding]; metal-binding site 632772012209 active site 632772012210 I-site; other site 632772012211 Predicted amidohydrolase [General function prediction only]; Region: COG0388 632772012212 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 632772012213 active site 632772012214 catalytic triad [active] 632772012215 dimer interface [polypeptide binding]; other site 632772012216 Amino acid permease; Region: AA_permease_2; pfam13520 632772012217 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772012218 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772012219 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 632772012220 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 632772012221 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 632772012222 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 632772012223 putative DNA binding site [nucleotide binding]; other site 632772012224 putative Zn2+ binding site [ion binding]; other site 632772012225 amidase; Provisional; Region: PRK07486 632772012226 Amidase; Region: Amidase; cl11426 632772012227 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 632772012228 Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120 632772012229 Membrane protein of unknown function; Region: DUF360; pfam04020 632772012230 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 632772012231 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 632772012232 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 632772012233 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 632772012234 Ligand Binding Site [chemical binding]; other site 632772012235 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 632772012236 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 632772012237 putative ligand binding site [chemical binding]; other site 632772012238 NAD binding site [chemical binding]; other site 632772012239 catalytic site [active] 632772012240 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 632772012241 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_12; cd08491 632772012242 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 632772012243 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772012244 dimer interface [polypeptide binding]; other site 632772012245 conserved gate region; other site 632772012246 putative PBP binding loops; other site 632772012247 ABC-ATPase subunit interface; other site 632772012248 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 632772012249 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772012250 dimer interface [polypeptide binding]; other site 632772012251 conserved gate region; other site 632772012252 putative PBP binding loops; other site 632772012253 ABC-ATPase subunit interface; other site 632772012254 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 632772012255 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 632772012256 Walker A/P-loop; other site 632772012257 ATP binding site [chemical binding]; other site 632772012258 Q-loop/lid; other site 632772012259 ABC transporter signature motif; other site 632772012260 Walker B; other site 632772012261 D-loop; other site 632772012262 H-loop/switch region; other site 632772012263 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 632772012264 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 632772012265 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 632772012266 Walker A/P-loop; other site 632772012267 ATP binding site [chemical binding]; other site 632772012268 Q-loop/lid; other site 632772012269 ABC transporter signature motif; other site 632772012270 Walker B; other site 632772012271 D-loop; other site 632772012272 H-loop/switch region; other site 632772012273 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 632772012274 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 632772012275 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 632772012276 active site 632772012277 tetramer interface [polypeptide binding]; other site 632772012278 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_6; cd12165 632772012279 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 632772012280 putative ligand binding site [chemical binding]; other site 632772012281 NAD binding site [chemical binding]; other site 632772012282 dimer interface [polypeptide binding]; other site 632772012283 putative catalytic site [active] 632772012284 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 632772012285 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 632772012286 AsnC family; Region: AsnC_trans_reg; pfam01037 632772012287 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 632772012288 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772012289 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 632772012290 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 632772012291 amidohydrolase; Region: amidohydrolases; TIGR01891 632772012292 putative metal binding site [ion binding]; other site 632772012293 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 632772012294 amidohydrolase; Region: amidohydrolases; TIGR01891 632772012295 metal binding site [ion binding]; metal-binding site 632772012296 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 632772012297 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 632772012298 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 632772012299 Low affinity iron permease; Region: Iron_permease; cl12096 632772012300 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 632772012301 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 632772012302 NAD(P) binding site [chemical binding]; other site 632772012303 catalytic residues [active] 632772012304 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 632772012305 hydrophobic ligand binding site; other site 632772012306 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 632772012307 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 632772012308 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 632772012309 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 632772012310 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772012311 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 632772012312 acyl-activating enzyme (AAE) consensus motif; other site 632772012313 acyl-activating enzyme (AAE) consensus motif; other site 632772012314 putative AMP binding site [chemical binding]; other site 632772012315 putative active site [active] 632772012316 putative CoA binding site [chemical binding]; other site 632772012317 enoyl-CoA hydratase; Provisional; Region: PRK06688 632772012318 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772012319 substrate binding site [chemical binding]; other site 632772012320 oxyanion hole (OAH) forming residues; other site 632772012321 trimer interface [polypeptide binding]; other site 632772012322 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 632772012323 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 632772012324 NAD(P) binding site [chemical binding]; other site 632772012325 enoyl-CoA hydratase; Provisional; Region: PRK08252 632772012326 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772012327 substrate binding site [chemical binding]; other site 632772012328 oxyanion hole (OAH) forming residues; other site 632772012329 trimer interface [polypeptide binding]; other site 632772012330 acetyl-CoA acetyltransferase; Provisional; Region: PRK06504 632772012331 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 632772012332 dimer interface [polypeptide binding]; other site 632772012333 active site 632772012334 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 632772012335 NAD binding site [chemical binding]; other site 632772012336 homodimer interface [polypeptide binding]; other site 632772012337 homotetramer interface [polypeptide binding]; other site 632772012338 active site 632772012339 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772012340 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772012341 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 632772012342 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 632772012343 FMN binding site [chemical binding]; other site 632772012344 substrate binding site [chemical binding]; other site 632772012345 putative catalytic residue [active] 632772012346 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772012347 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772012348 active site 632772012349 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 632772012350 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 632772012351 FMN binding site [chemical binding]; other site 632772012352 substrate binding site [chemical binding]; other site 632772012353 putative catalytic residue [active] 632772012354 enoyl-CoA hydratase; Provisional; Region: PRK08260 632772012355 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772012356 substrate binding site [chemical binding]; other site 632772012357 oxyanion hole (OAH) forming residues; other site 632772012358 trimer interface [polypeptide binding]; other site 632772012359 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772012360 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772012361 Pleckstrin homology-like domain; Region: PH-like; cl17171 632772012362 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 632772012363 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772012364 putative substrate translocation pore; other site 632772012365 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 632772012366 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772012367 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 632772012368 acyl-activating enzyme (AAE) consensus motif; other site 632772012369 putative AMP binding site [chemical binding]; other site 632772012370 putative active site [active] 632772012371 putative CoA binding site [chemical binding]; other site 632772012372 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772012373 metabolite-proton symporter; Region: 2A0106; TIGR00883 632772012374 putative substrate translocation pore; other site 632772012375 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 632772012376 putative active site [active] 632772012377 putative substrate binding site [chemical binding]; other site 632772012378 ATP binding site [chemical binding]; other site 632772012379 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772012380 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772012381 active site 632772012382 acyl-CoA synthetase; Validated; Region: PRK08316 632772012383 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772012384 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 632772012385 acyl-activating enzyme (AAE) consensus motif; other site 632772012386 putative AMP binding site [chemical binding]; other site 632772012387 putative active site [active] 632772012388 putative CoA binding site [chemical binding]; other site 632772012389 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772012390 metabolite-proton symporter; Region: 2A0106; TIGR00883 632772012391 putative substrate translocation pore; other site 632772012392 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 632772012393 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 632772012394 cyclase homology domain; Region: CHD; cd07302 632772012395 nucleotidyl binding site; other site 632772012396 metal binding site [ion binding]; metal-binding site 632772012397 dimer interface [polypeptide binding]; other site 632772012398 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632772012399 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632772012400 active site 632772012401 phosphorylation site [posttranslational modification] 632772012402 intermolecular recognition site; other site 632772012403 dimerization interface [polypeptide binding]; other site 632772012404 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632772012405 DNA binding residues [nucleotide binding] 632772012406 dimerization interface [polypeptide binding]; other site 632772012407 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 632772012408 Histidine kinase; Region: HisKA_3; pfam07730 632772012409 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632772012410 ATP binding site [chemical binding]; other site 632772012411 Mg2+ binding site [ion binding]; other site 632772012412 G-X-G motif; other site 632772012413 FtsX-like permease family; Region: FtsX; pfam02687 632772012414 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 632772012415 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 632772012416 Walker A/P-loop; other site 632772012417 ATP binding site [chemical binding]; other site 632772012418 Q-loop/lid; other site 632772012419 ABC transporter signature motif; other site 632772012420 Walker B; other site 632772012421 D-loop; other site 632772012422 H-loop/switch region; other site 632772012423 benzoate transport; Region: 2A0115; TIGR00895 632772012424 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772012425 putative substrate translocation pore; other site 632772012426 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772012427 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 632772012428 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 632772012429 NAD(P) binding site [chemical binding]; other site 632772012430 catalytic residues [active] 632772012431 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 632772012432 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 632772012433 active site 632772012434 metal binding site [ion binding]; metal-binding site 632772012435 C-terminal, catalytic, domain of BphC5 (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacterium Rhodococcus rhodochrous K37 and similar proteins; Region: BphC5-RK37_C_like; cd07239 632772012436 putative active site [active] 632772012437 Mn binding site [ion binding]; other site 632772012438 putative oligomer interface [polypeptide binding]; other site 632772012439 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 632772012440 TAP-like protein; Region: Abhydrolase_4; pfam08386 632772012441 Cupin domain; Region: Cupin_2; pfam07883 632772012442 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 632772012443 classical (c) SDRs; Region: SDR_c; cd05233 632772012444 NAD(P) binding site [chemical binding]; other site 632772012445 active site 632772012446 short chain dehydrogenase; Provisional; Region: PRK07062 632772012447 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 632772012448 putative NAD(P) binding site [chemical binding]; other site 632772012449 putative active site [active] 632772012450 hypothetical protein; Provisional; Region: PRK07064 632772012451 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 632772012452 PYR/PP interface [polypeptide binding]; other site 632772012453 dimer interface [polypeptide binding]; other site 632772012454 TPP binding site [chemical binding]; other site 632772012455 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 632772012456 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 632772012457 TPP-binding site [chemical binding]; other site 632772012458 FAD binding domain; Region: FAD_binding_3; pfam01494 632772012459 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 632772012460 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 632772012461 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 632772012462 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 632772012463 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 632772012464 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 632772012465 XdhC Rossmann domain; Region: XdhC_C; pfam13478 632772012466 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 632772012467 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 632772012468 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 632772012469 catalytic loop [active] 632772012470 iron binding site [ion binding]; other site 632772012471 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 632772012472 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 632772012473 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 632772012474 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 632772012475 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 632772012476 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 632772012477 AsnC family; Region: AsnC_trans_reg; pfam01037 632772012478 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 632772012479 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 632772012480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772012481 metabolite-proton symporter; Region: 2A0106; TIGR00883 632772012482 putative substrate translocation pore; other site 632772012483 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 632772012484 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 632772012485 Catalytic domain of Protein Kinases; Region: PKc; cd00180 632772012486 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 632772012487 active site 632772012488 ATP binding site [chemical binding]; other site 632772012489 substrate binding site [chemical binding]; other site 632772012490 activation loop (A-loop); other site 632772012491 Predicted ATPase [General function prediction only]; Region: COG3903 632772012492 Tetratricopeptide repeat; Region: TPR_12; pfam13424 632772012493 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632772012494 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632772012495 DNA binding residues [nucleotide binding] 632772012496 dimerization interface [polypeptide binding]; other site 632772012497 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 632772012498 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 632772012499 FMN-binding pocket [chemical binding]; other site 632772012500 flavin binding motif; other site 632772012501 phosphate binding motif [ion binding]; other site 632772012502 beta-alpha-beta structure motif; other site 632772012503 NAD binding pocket [chemical binding]; other site 632772012504 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 632772012505 catalytic loop [active] 632772012506 iron binding site [ion binding]; other site 632772012507 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 632772012508 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 632772012509 iron-sulfur cluster [ion binding]; other site 632772012510 [2Fe-2S] cluster binding site [ion binding]; other site 632772012511 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 632772012512 hydrophobic ligand binding site; other site 632772012513 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 632772012514 MarR family; Region: MarR; pfam01047 632772012515 MarR family; Region: MarR_2; cl17246 632772012516 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 632772012517 homotrimer interaction site [polypeptide binding]; other site 632772012518 putative active site [active] 632772012519 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 632772012520 Fe-S cluster binding site [ion binding]; other site 632772012521 active site 632772012522 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 632772012523 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 632772012524 putative NAD(P) binding site [chemical binding]; other site 632772012525 Copper resistance protein D; Region: CopD; cl00563 632772012526 CopC domain; Region: CopC; pfam04234 632772012527 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 632772012528 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 632772012529 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 632772012530 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 632772012531 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772012532 S-adenosylmethionine binding site [chemical binding]; other site 632772012533 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772012534 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 632772012535 NAD(P) binding site [chemical binding]; other site 632772012536 active site 632772012537 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 632772012538 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 632772012539 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 632772012540 ligand binding site [chemical binding]; other site 632772012541 flexible hinge region; other site 632772012542 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632772012543 ATP binding site [chemical binding]; other site 632772012544 Mg2+ binding site [ion binding]; other site 632772012545 G-X-G motif; other site 632772012546 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 632772012547 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632772012548 active site 632772012549 phosphorylation site [posttranslational modification] 632772012550 intermolecular recognition site; other site 632772012551 dimerization interface [polypeptide binding]; other site 632772012552 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 632772012553 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 632772012554 Predicted membrane protein [Function unknown]; Region: COG2119 632772012555 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 632772012556 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 632772012557 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 632772012558 putative metal binding residues [ion binding]; other site 632772012559 signature motif; other site 632772012560 dimer interface [polypeptide binding]; other site 632772012561 active site 632772012562 polyP binding site; other site 632772012563 substrate binding site [chemical binding]; other site 632772012564 acceptor-phosphate pocket; other site 632772012565 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 632772012566 Spore coat assembly protein [Cell envelope biogenesis, outer membrane]; Region: CotH; COG5337 632772012567 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 632772012568 amidase; Provisional; Region: PRK07869 632772012569 Amidase; Region: Amidase; cl11426 632772012570 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 632772012571 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 632772012572 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 632772012573 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 632772012574 methionine sulfoxide reductase A; Provisional; Region: PRK00058 632772012575 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 632772012576 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772012577 NADH(P)-binding; Region: NAD_binding_10; pfam13460 632772012578 NAD(P) binding site [chemical binding]; other site 632772012579 active site 632772012580 Cupin; Region: Cupin_6; pfam12852 632772012581 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 632772012582 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632772012583 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 632772012584 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 632772012585 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 632772012586 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 632772012587 tandem repeat interface [polypeptide binding]; other site 632772012588 oligomer interface [polypeptide binding]; other site 632772012589 active site residues [active] 632772012590 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 632772012591 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 632772012592 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 632772012593 active site 632772012594 catalytic site [active] 632772012595 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 632772012596 Ferritin-like domain; Region: Ferritin; pfam00210 632772012597 ferroxidase diiron center [ion binding]; other site 632772012598 Secretory lipase; Region: LIP; pfam03583 632772012599 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 632772012600 Ferritin-like domain; Region: Ferritin; pfam00210 632772012601 ferroxidase diiron center [ion binding]; other site 632772012602 Transcriptional regulator [Transcription]; Region: LytR; COG1316 632772012603 CAAX protease self-immunity; Region: Abi; pfam02517 632772012604 prephenate dehydratase; Provisional; Region: PRK11898 632772012605 Prephenate dehydratase; Region: PDT; pfam00800 632772012606 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 632772012607 putative L-Phe binding site [chemical binding]; other site 632772012608 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 632772012609 catalytic core [active] 632772012610 Lipase maturation factor; Region: LMF1; pfam06762 632772012611 EspG family; Region: ESX-1_EspG; pfam14011 632772012612 PPE family; Region: PPE; pfam00823 632772012613 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 632772012614 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 632772012615 Septum formation; Region: Septum_form; pfam13845 632772012616 Septum formation; Region: Septum_form; pfam13845 632772012617 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 632772012618 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 632772012619 seryl-tRNA synthetase; Provisional; Region: PRK05431 632772012620 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 632772012621 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 632772012622 dimer interface [polypeptide binding]; other site 632772012623 active site 632772012624 motif 1; other site 632772012625 motif 2; other site 632772012626 motif 3; other site 632772012627 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 632772012628 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 632772012629 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 632772012630 heme binding site [chemical binding]; other site 632772012631 ferroxidase pore; other site 632772012632 ferroxidase diiron center [ion binding]; other site 632772012633 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 632772012634 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 632772012635 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 632772012636 iron-sulfur cluster [ion binding]; other site 632772012637 [2Fe-2S] cluster binding site [ion binding]; other site 632772012638 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 632772012639 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 632772012640 putative acyl-acceptor binding pocket; other site 632772012641 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 632772012642 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 632772012643 putative acyl-acceptor binding pocket; other site 632772012644 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632772012645 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 632772012646 active site 632772012647 motif I; other site 632772012648 motif II; other site 632772012649 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632772012650 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 632772012651 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 632772012652 amidase catalytic site [active] 632772012653 Zn binding residues [ion binding]; other site 632772012654 substrate binding site [chemical binding]; other site 632772012655 LGFP repeat; Region: LGFP; pfam08310 632772012656 Stage II sporulation protein; Region: SpoIID; pfam08486 632772012657 LGFP repeat; Region: LGFP; pfam08310 632772012658 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 632772012659 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 632772012660 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 632772012661 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 632772012662 UDP-galactopyranose mutase; Region: GLF; pfam03275 632772012663 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 632772012664 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 632772012665 active site 632772012666 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 632772012667 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 632772012668 Putative esterase; Region: Esterase; pfam00756 632772012669 S-formylglutathione hydrolase; Region: PLN02442 632772012670 Predicted esterase [General function prediction only]; Region: COG0627 632772012671 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 632772012672 Putative esterase; Region: Esterase; pfam00756 632772012673 S-formylglutathione hydrolase; Region: PLN02442 632772012674 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 632772012675 LGFP repeat; Region: LGFP; pfam08310 632772012676 LGFP repeat; Region: LGFP; pfam08310 632772012677 LGFP repeat; Region: LGFP; pfam08310 632772012678 Cutinase; Region: Cutinase; pfam01083 632772012679 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 632772012680 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 632772012681 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 632772012682 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 632772012683 acyl-activating enzyme (AAE) consensus motif; other site 632772012684 active site 632772012685 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 632772012686 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 632772012687 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 632772012688 active site 632772012689 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 632772012690 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 632772012691 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 632772012692 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 632772012693 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 632772012694 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 632772012695 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 632772012696 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 632772012697 MspA; Region: MspA; pfam09203 632772012698 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 632772012699 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 632772012700 short chain dehydrogenase; Provisional; Region: PRK07904 632772012701 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 632772012702 NAD(P) binding site [chemical binding]; other site 632772012703 active site 632772012704 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 632772012705 FAD binding domain; Region: FAD_binding_4; pfam01565 632772012706 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 632772012707 Predicted membrane protein [Function unknown]; Region: COG2246 632772012708 GtrA-like protein; Region: GtrA; pfam04138 632772012709 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 632772012710 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 632772012711 substrate binding pocket [chemical binding]; other site 632772012712 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 632772012713 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 632772012714 protein binding site [polypeptide binding]; other site 632772012715 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 632772012716 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 632772012717 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 632772012718 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 632772012719 substrate binding site; other site 632772012720 tetramer interface; other site 632772012721 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 632772012722 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 632772012723 NAD binding site [chemical binding]; other site 632772012724 substrate binding site [chemical binding]; other site 632772012725 homodimer interface [polypeptide binding]; other site 632772012726 active site 632772012727 Methyltransferase domain; Region: Methyltransf_23; pfam13489 632772012728 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772012729 S-adenosylmethionine binding site [chemical binding]; other site 632772012730 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 632772012731 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 632772012732 putative trimer interface [polypeptide binding]; other site 632772012733 putative CoA binding site [chemical binding]; other site 632772012734 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 632772012735 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 632772012736 inhibitor-cofactor binding pocket; inhibition site 632772012737 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632772012738 catalytic residue [active] 632772012739 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 632772012740 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 632772012741 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 632772012742 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 632772012743 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 632772012744 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 632772012745 non-specific DNA binding site [nucleotide binding]; other site 632772012746 salt bridge; other site 632772012747 sequence-specific DNA binding site [nucleotide binding]; other site 632772012748 Cupin domain; Region: Cupin_2; pfam07883 632772012749 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 632772012750 active site 632772012751 catalytic triad [active] 632772012752 oxyanion hole [active] 632772012753 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 632772012754 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 632772012755 active site 632772012756 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 632772012757 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 632772012758 active site 632772012759 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 632772012760 Methyltransferase domain; Region: Methyltransf_24; pfam13578 632772012761 GTPase RsgA; Reviewed; Region: PRK01889 632772012762 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 632772012763 GTPase/Zn-binding domain interface [polypeptide binding]; other site 632772012764 GTP/Mg2+ binding site [chemical binding]; other site 632772012765 G4 box; other site 632772012766 G5 box; other site 632772012767 G1 box; other site 632772012768 Switch I region; other site 632772012769 G2 box; other site 632772012770 G3 box; other site 632772012771 Switch II region; other site 632772012772 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 632772012773 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 632772012774 active site 632772012775 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 632772012776 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 632772012777 Walker A/P-loop; other site 632772012778 ATP binding site [chemical binding]; other site 632772012779 Q-loop/lid; other site 632772012780 ABC transporter signature motif; other site 632772012781 Walker B; other site 632772012782 D-loop; other site 632772012783 H-loop/switch region; other site 632772012784 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 632772012785 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 632772012786 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 632772012787 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 632772012788 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 632772012789 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 632772012790 catalytic residue [active] 632772012791 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 632772012792 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 632772012793 NAD(P) binding site [chemical binding]; other site 632772012794 Transcriptional regulators [Transcription]; Region: MarR; COG1846 632772012795 MarR family; Region: MarR_2; cl17246 632772012796 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 632772012797 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 632772012798 Int/Topo IB signature motif; other site 632772012799 Helix-turn-helix domain; Region: HTH_17; cl17695 632772012800 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 632772012801 active site 632772012802 metal binding site [ion binding]; metal-binding site 632772012803 interdomain interaction site; other site 632772012804 AAA domain; Region: AAA_25; pfam13481 632772012805 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 632772012806 Walker A motif; other site 632772012807 ATP binding site [chemical binding]; other site 632772012808 Walker B motif; other site 632772012809 Phage capsid family; Region: Phage_capsid; pfam05065 632772012810 LabA_like proteins; Region: LabA_like; cd06167 632772012811 putative metal binding site [ion binding]; other site 632772012812 TfoX N-terminal domain; Region: TfoX_N; cl17592 632772012813 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 632772012814 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 632772012815 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 632772012816 potential frameshift: common BLAST hit: gi|148821777|ref|YP_001286531.1| ArsR family transcriptional regulator 632772012817 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 632772012818 putative hydrophobic ligand binding site [chemical binding]; other site 632772012819 TIGR03086 family protein; Region: TIGR03086 632772012820 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 632772012821 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632772012822 dimerization interface [polypeptide binding]; other site 632772012823 putative DNA binding site [nucleotide binding]; other site 632772012824 putative Zn2+ binding site [ion binding]; other site 632772012825 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 632772012826 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 632772012827 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 632772012828 Putative esterase; Region: Esterase; pfam00756 632772012829 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 632772012830 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 632772012831 homodimer interface [polypeptide binding]; other site 632772012832 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632772012833 catalytic residue [active] 632772012834 Dienelactone hydrolase family; Region: DLH; pfam01738 632772012835 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 632772012836 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 632772012837 non-specific DNA binding site [nucleotide binding]; other site 632772012838 salt bridge; other site 632772012839 sequence-specific DNA binding site [nucleotide binding]; other site 632772012840 BRO family, N-terminal domain; Region: Bro-N; smart01040 632772012841 Prophage antirepressor [Transcription]; Region: COG3617 632772012842 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 632772012843 Transcription factor WhiB; Region: Whib; pfam02467 632772012844 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 632772012845 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 632772012846 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 632772012847 polymerase nucleotide-binding site; other site 632772012848 DNA-binding residues [nucleotide binding]; DNA binding site 632772012849 nucleotide binding site [chemical binding]; other site 632772012850 primase nucleotide-binding site [nucleotide binding]; other site 632772012851 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 632772012852 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 632772012853 Right handed beta helix region; Region: Beta_helix; pfam13229 632772012854 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 632772012855 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 632772012856 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 632772012857 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 632772012858 Tropomyosin like; Region: Tropomyosin_1; pfam12718 632772012859 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 632772012860 Phage-related protein [Function unknown]; Region: COG5412 632772012861 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 632772012862 N-acetyl-D-glucosamine binding site [chemical binding]; other site 632772012863 catalytic residue [active] 632772012864 PE-PPE domain; Region: PE-PPE; pfam08237 632772012865 Protein of unknown function (DUF2744); Region: DUF2744; pfam10910 632772012866 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 632772012867 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712 632772012868 LGFP repeat; Region: LGFP; pfam08310 632772012869 LGFP repeat; Region: LGFP; pfam08310 632772012870 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 632772012871 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 632772012872 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 632772012873 active site 632772012874 catalytic residues [active] 632772012875 DNA binding site [nucleotide binding] 632772012876 Int/Topo IB signature motif; other site 632772012877 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 632772012878 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 632772012879 putative metal binding site [ion binding]; other site 632772012880 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632772012881 dimerization interface [polypeptide binding]; other site 632772012882 putative DNA binding site [nucleotide binding]; other site 632772012883 putative Zn2+ binding site [ion binding]; other site 632772012884 SnoaL-like domain; Region: SnoaL_2; pfam12680 632772012885 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 632772012886 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 632772012887 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 632772012888 putative dimerization interface [polypeptide binding]; other site 632772012889 gluconate 5-dehydrogenase; Provisional; Region: PRK07523 632772012890 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 632772012891 NADP binding site [chemical binding]; other site 632772012892 homodimer interface [polypeptide binding]; other site 632772012893 active site 632772012894 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 632772012895 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 632772012896 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 632772012897 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772012898 metabolite-proton symporter; Region: 2A0106; TIGR00883 632772012899 putative substrate translocation pore; other site 632772012900 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 632772012901 oxidoreductase family protein; Region: PLN02928 632772012902 NAD binding site [chemical binding]; other site 632772012903 ligand binding site [chemical binding]; other site 632772012904 catalytic site [active] 632772012905 Short C-terminal domain; Region: SHOCT; pfam09851 632772012906 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 632772012907 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 632772012908 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772012909 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632772012910 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 632772012911 Beta-lactamase; Region: Beta-lactamase; pfam00144 632772012912 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772012913 NmrA-like family; Region: NmrA; pfam05368 632772012914 NAD(P) binding site [chemical binding]; other site 632772012915 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 632772012916 additional DNA contacts [nucleotide binding]; other site 632772012917 mismatch recognition site; other site 632772012918 active site 632772012919 zinc binding site [ion binding]; other site 632772012920 DNA intercalation site [nucleotide binding]; other site 632772012921 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 632772012922 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 632772012923 cofactor binding site; other site 632772012924 DNA binding site [nucleotide binding] 632772012925 substrate interaction site [chemical binding]; other site 632772012926 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 632772012927 prephenate dehydrogenase; Validated; Region: PRK06545 632772012928 prephenate dehydrogenase; Validated; Region: PRK08507 632772012929 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 632772012930 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 632772012931 nucleoside/Zn binding site; other site 632772012932 dimer interface [polypeptide binding]; other site 632772012933 catalytic motif [active] 632772012934 CsbD-like; Region: CsbD; pfam05532 632772012935 YceI-like domain; Region: YceI; pfam04264 632772012936 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 632772012937 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 632772012938 Predicted transcriptional regulator [Transcription]; Region: COG1959 632772012939 Transcriptional regulator; Region: Rrf2; pfam02082 632772012940 Transcriptional regulator [Transcription]; Region: IclR; COG1414 632772012941 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 632772012942 Bacterial transcriptional regulator; Region: IclR; pfam01614 632772012943 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 632772012944 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 632772012945 FMN-binding pocket [chemical binding]; other site 632772012946 flavin binding motif; other site 632772012947 phosphate binding motif [ion binding]; other site 632772012948 beta-alpha-beta structure motif; other site 632772012949 NAD binding pocket [chemical binding]; other site 632772012950 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 632772012951 catalytic loop [active] 632772012952 iron binding site [ion binding]; other site 632772012953 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 632772012954 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 632772012955 iron-sulfur cluster [ion binding]; other site 632772012956 [2Fe-2S] cluster binding site [ion binding]; other site 632772012957 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 632772012958 alpha subunit interface [polypeptide binding]; other site 632772012959 active site 632772012960 substrate binding site [chemical binding]; other site 632772012961 Fe binding site [ion binding]; other site 632772012962 hypothetical protein; Provisional; Region: PRK08317 632772012963 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772012964 S-adenosylmethionine binding site [chemical binding]; other site 632772012965 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 632772012966 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772012967 MMPL family; Region: MMPL; pfam03176 632772012968 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 632772012969 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 632772012970 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 632772012971 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632772012972 Walker A/P-loop; other site 632772012973 ATP binding site [chemical binding]; other site 632772012974 Q-loop/lid; other site 632772012975 ABC transporter signature motif; other site 632772012976 Walker B; other site 632772012977 D-loop; other site 632772012978 H-loop/switch region; other site 632772012979 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 632772012980 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 632772012981 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 632772012982 Walker A/P-loop; other site 632772012983 ATP binding site [chemical binding]; other site 632772012984 Q-loop/lid; other site 632772012985 ABC transporter signature motif; other site 632772012986 Walker B; other site 632772012987 D-loop; other site 632772012988 H-loop/switch region; other site 632772012989 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 632772012990 Sulfatase; Region: Sulfatase; cl17466 632772012991 Sulfatase; Region: Sulfatase; cl17466 632772012992 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 632772012993 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 632772012994 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 632772012995 RDD family; Region: RDD; pfam06271 632772012996 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 632772012997 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 632772012998 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 632772012999 active site 632772013000 HIGH motif; other site 632772013001 nucleotide binding site [chemical binding]; other site 632772013002 active site 632772013003 KMSKS motif; other site 632772013004 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772013005 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772013006 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 632772013007 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 632772013008 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 632772013009 NADP+ binding site [chemical binding]; other site 632772013010 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772013011 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 632772013012 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 632772013013 putative acyl-acceptor binding pocket; other site 632772013014 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772013015 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772013016 WHG domain; Region: WHG; pfam13305 632772013017 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 632772013018 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 632772013019 putative active site [active] 632772013020 putative metal binding site [ion binding]; other site 632772013021 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 632772013022 TIGR03086 family protein; Region: TIGR03086 632772013023 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 632772013024 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632772013025 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 632772013026 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 632772013027 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 632772013028 Putative esterase; Region: Esterase; pfam00756 632772013029 S-formylglutathione hydrolase; Region: PLN02442 632772013030 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 632772013031 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 632772013032 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632772013033 homodimer interface [polypeptide binding]; other site 632772013034 catalytic residue [active] 632772013035 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 632772013036 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 632772013037 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 632772013038 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 632772013039 intersubunit interface [polypeptide binding]; other site 632772013040 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 632772013041 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 632772013042 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 632772013043 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 632772013044 minor groove reading motif; other site 632772013045 helix-hairpin-helix signature motif; other site 632772013046 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 632772013047 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 632772013048 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632772013049 Walker A motif; other site 632772013050 ATP binding site [chemical binding]; other site 632772013051 Walker B motif; other site 632772013052 arginine finger; other site 632772013053 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 632772013054 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 632772013055 Histidine kinase; Region: HisKA_3; pfam07730 632772013056 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 632772013057 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632772013058 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632772013059 active site 632772013060 phosphorylation site [posttranslational modification] 632772013061 intermolecular recognition site; other site 632772013062 dimerization interface [polypeptide binding]; other site 632772013063 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632772013064 DNA binding residues [nucleotide binding] 632772013065 dimerization interface [polypeptide binding]; other site 632772013066 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 632772013067 Amidase; Region: Amidase; cl11426 632772013068 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 632772013069 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 632772013070 dimer interface [polypeptide binding]; other site 632772013071 active site 632772013072 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772013073 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 632772013074 substrate binding site [chemical binding]; other site 632772013075 oxyanion hole (OAH) forming residues; other site 632772013076 trimer interface [polypeptide binding]; other site 632772013077 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 632772013078 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 632772013079 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 632772013080 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 632772013081 Protein of unknown function (DUF3990); Region: DUF3990; pfam13151 632772013082 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772013083 S-adenosylmethionine binding site [chemical binding]; other site 632772013084 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 632772013085 FAD binding domain; Region: FAD_binding_4; pfam01565 632772013086 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 632772013087 hypothetical protein; Validated; Region: PRK00153 632772013088 recombination protein RecR; Reviewed; Region: recR; PRK00076 632772013089 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 632772013090 RecR protein; Region: RecR; pfam02132 632772013091 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 632772013092 putative active site [active] 632772013093 putative metal-binding site [ion binding]; other site 632772013094 tetramer interface [polypeptide binding]; other site 632772013095 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772013096 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772013097 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772013098 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 632772013099 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632772013100 dimerization interface [polypeptide binding]; other site 632772013101 putative DNA binding site [nucleotide binding]; other site 632772013102 putative Zn2+ binding site [ion binding]; other site 632772013103 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_5; cd08898 632772013104 putative hydrophobic ligand binding site [chemical binding]; other site 632772013105 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 632772013106 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 632772013107 conserved cys residue [active] 632772013108 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 632772013109 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 632772013110 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 632772013111 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 632772013112 EamA-like transporter family; Region: EamA; pfam00892 632772013113 EamA-like transporter family; Region: EamA; pfam00892 632772013114 Transcriptional regulator [Transcription]; Region: LysR; COG0583 632772013115 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632772013116 putative DNA binding site [nucleotide binding]; other site 632772013117 putative Zn2+ binding site [ion binding]; other site 632772013118 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 632772013119 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 632772013120 Short C-terminal domain; Region: SHOCT; pfam09851 632772013121 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 632772013122 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 632772013123 ATP-grasp domain; Region: ATP-grasp_4; cl17255 632772013124 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 632772013125 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 632772013126 carboxyltransferase (CT) interaction site; other site 632772013127 biotinylation site [posttranslational modification]; other site 632772013128 Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326 632772013129 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 632772013130 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 632772013131 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 632772013132 D-pathway; other site 632772013133 Putative ubiquinol binding site [chemical binding]; other site 632772013134 Low-spin heme (heme b) binding site [chemical binding]; other site 632772013135 Putative water exit pathway; other site 632772013136 Binuclear center (heme o3/CuB) [ion binding]; other site 632772013137 K-pathway; other site 632772013138 Putative proton exit pathway; other site 632772013139 2-isopropylmalate synthase; Validated; Region: PRK03739 632772013140 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 632772013141 active site 632772013142 catalytic residues [active] 632772013143 metal binding site [ion binding]; metal-binding site 632772013144 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 632772013145 Pirin-related protein [General function prediction only]; Region: COG1741 632772013146 Pirin; Region: Pirin; pfam02678 632772013147 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 632772013148 Protein of unknown function (DUF732); Region: DUF732; pfam05305 632772013149 Erythronolide synthase docking; Region: Docking; pfam08990 632772013150 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 632772013151 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 632772013152 active site 632772013153 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 632772013154 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 632772013155 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 632772013156 putative NADP binding site [chemical binding]; other site 632772013157 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 632772013158 active site 632772013159 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 632772013160 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 632772013161 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 632772013162 active site 632772013163 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 632772013164 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 632772013165 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 632772013166 putative NADP binding site [chemical binding]; other site 632772013167 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 632772013168 active site 632772013169 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 632772013170 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 632772013171 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772013172 S-adenosylmethionine binding site [chemical binding]; other site 632772013173 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632772013174 dimerization interface [polypeptide binding]; other site 632772013175 putative DNA binding site [nucleotide binding]; other site 632772013176 Predicted transcriptional regulator [Transcription]; Region: COG2345 632772013177 putative Zn2+ binding site [ion binding]; other site 632772013178 DoxX; Region: DoxX; cl17842 632772013179 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 632772013180 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 632772013181 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 632772013182 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 632772013183 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 632772013184 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 632772013185 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 632772013186 metal binding site [ion binding]; metal-binding site 632772013187 putative dimer interface [polypeptide binding]; other site 632772013188 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 632772013189 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 632772013190 siderophore binding site; other site 632772013191 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 632772013192 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865 632772013193 putative hydrophobic ligand binding site [chemical binding]; other site 632772013194 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 632772013195 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 632772013196 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 632772013197 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 632772013198 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772013199 active site 632772013200 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772013201 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 632772013202 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772013203 substrate binding site [chemical binding]; other site 632772013204 oxyanion hole (OAH) forming residues; other site 632772013205 trimer interface [polypeptide binding]; other site 632772013206 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 632772013207 active site 632772013208 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 632772013209 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 632772013210 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 632772013211 nucleophilic elbow; other site 632772013212 catalytic triad; other site 632772013213 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; pfam09837 632772013214 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 632772013215 Ligand binding site; other site 632772013216 Putative Catalytic site; other site 632772013217 DXD motif; other site 632772013218 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 632772013219 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772013220 NAD(P) binding site [chemical binding]; other site 632772013221 active site 632772013222 5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823 632772013223 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772013224 S-adenosylmethionine binding site [chemical binding]; other site 632772013225 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 632772013226 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 632772013227 Moco binding site; other site 632772013228 metal coordination site [ion binding]; other site 632772013229 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 632772013230 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 632772013231 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772013232 putative substrate translocation pore; other site 632772013233 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 632772013234 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 632772013235 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 632772013236 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 632772013237 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 632772013238 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632772013239 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 632772013240 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772013241 dimer interface [polypeptide binding]; other site 632772013242 conserved gate region; other site 632772013243 putative PBP binding loops; other site 632772013244 ABC-ATPase subunit interface; other site 632772013245 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772013246 dimer interface [polypeptide binding]; other site 632772013247 conserved gate region; other site 632772013248 putative PBP binding loops; other site 632772013249 ABC-ATPase subunit interface; other site 632772013250 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 632772013251 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 632772013252 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 632772013253 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 632772013254 active site 632772013255 catalytic site [active] 632772013256 Transcriptional regulators [Transcription]; Region: PurR; COG1609 632772013257 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 632772013258 DNA binding site [nucleotide binding] 632772013259 domain linker motif; other site 632772013260 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 632772013261 ligand binding site [chemical binding]; other site 632772013262 dimerization interface [polypeptide binding]; other site 632772013263 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 632772013264 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 632772013265 Walker A/P-loop; other site 632772013266 ATP binding site [chemical binding]; other site 632772013267 Q-loop/lid; other site 632772013268 ABC transporter signature motif; other site 632772013269 Walker B; other site 632772013270 D-loop; other site 632772013271 H-loop/switch region; other site 632772013272 TOBE domain; Region: TOBE_2; pfam08402 632772013273 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 632772013274 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 632772013275 nucleotide binding site [chemical binding]; other site 632772013276 Transcription factor WhiB; Region: Whib; pfam02467 632772013277 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 632772013278 Catalytic domain of Protein Kinases; Region: PKc; cd00180 632772013279 active site 632772013280 ATP binding site [chemical binding]; other site 632772013281 substrate binding site [chemical binding]; other site 632772013282 activation loop (A-loop); other site 632772013283 Uncharacterized conserved protein [Function unknown]; Region: COG3391 632772013284 NHL repeat; Region: NHL; pfam01436 632772013285 NHL repeat; Region: NHL; pfam01436 632772013286 AAA ATPase domain; Region: AAA_16; pfam13191 632772013287 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 632772013288 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632772013289 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632772013290 DNA binding residues [nucleotide binding] 632772013291 dimerization interface [polypeptide binding]; other site 632772013292 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 632772013293 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 632772013294 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 632772013295 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 632772013296 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 632772013297 Sulfate transporter family; Region: Sulfate_transp; pfam00916 632772013298 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 632772013299 high affinity sulphate transporter 1; Region: sulP; TIGR00815 632772013300 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 632772013301 Sulfate transporter family; Region: Sulfate_transp; pfam00916 632772013302 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 632772013303 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 632772013304 Sulfatase; Region: Sulfatase; pfam00884 632772013305 Uncharacterized conserved protein [Function unknown]; Region: COG5361 632772013306 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 632772013307 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 632772013308 aspartate kinase; Reviewed; Region: PRK06635 632772013309 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 632772013310 putative nucleotide binding site [chemical binding]; other site 632772013311 putative catalytic residues [active] 632772013312 putative Mg ion binding site [ion binding]; other site 632772013313 putative aspartate binding site [chemical binding]; other site 632772013314 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 632772013315 putative allosteric regulatory site; other site 632772013316 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 632772013317 putative allosteric regulatory residue; other site 632772013318 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 632772013319 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 632772013320 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 632772013321 Uncharacterized conserved protein [Function unknown]; Region: COG1262 632772013322 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 632772013323 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 632772013324 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772013325 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772013326 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 632772013327 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 632772013328 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 632772013329 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 632772013330 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 632772013331 putative hydrophobic ligand binding site [chemical binding]; other site 632772013332 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632772013333 dimerization interface [polypeptide binding]; other site 632772013334 putative DNA binding site [nucleotide binding]; other site 632772013335 putative Zn2+ binding site [ion binding]; other site 632772013336 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 632772013337 metal binding site 2 [ion binding]; metal-binding site 632772013338 putative DNA binding helix; other site 632772013339 metal binding site 1 [ion binding]; metal-binding site 632772013340 dimer interface [polypeptide binding]; other site 632772013341 structural Zn2+ binding site [ion binding]; other site 632772013342 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 632772013343 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 632772013344 tetramer interface [polypeptide binding]; other site 632772013345 heme binding pocket [chemical binding]; other site 632772013346 NADPH binding site [chemical binding]; other site 632772013347 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 632772013348 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 632772013349 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 632772013350 siderophore binding site; other site 632772013351 phosphodiesterase YaeI; Provisional; Region: PRK11340 632772013352 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 632772013353 putative active site [active] 632772013354 putative metal binding site [ion binding]; other site 632772013355 Yqey-like protein; Region: YqeY; pfam09424 632772013356 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 632772013357 Transglycosylase; Region: Transgly; pfam00912 632772013358 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 632772013359 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 632772013360 Transcription factor WhiB; Region: Whib; pfam02467 632772013361 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 632772013362 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 632772013363 DTAP/Switch II; other site 632772013364 Switch I; other site 632772013365 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 632772013366 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 632772013367 P loop; other site 632772013368 Nucleotide binding site [chemical binding]; other site 632772013369 DTAP/Switch II; other site 632772013370 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 632772013371 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 632772013372 homotrimer interaction site [polypeptide binding]; other site 632772013373 putative active site [active] 632772013374 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 632772013375 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 632772013376 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 632772013377 ligand binding site [chemical binding]; other site 632772013378 flexible hinge region; other site 632772013379 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 632772013380 putative switch regulator; other site 632772013381 non-specific DNA interactions [nucleotide binding]; other site 632772013382 DNA binding site [nucleotide binding] 632772013383 sequence specific DNA binding site [nucleotide binding]; other site 632772013384 putative cAMP binding site [chemical binding]; other site 632772013385 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 632772013386 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 632772013387 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 632772013388 minor groove reading motif; other site 632772013389 helix-hairpin-helix signature motif; other site 632772013390 substrate binding pocket [chemical binding]; other site 632772013391 active site 632772013392 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 632772013393 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 632772013394 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 632772013395 catalytic residues [active] 632772013396 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 632772013397 putative active site [active] 632772013398 putative CoA binding site [chemical binding]; other site 632772013399 nudix motif; other site 632772013400 metal binding site [ion binding]; metal-binding site 632772013401 Colicin V production protein; Region: Colicin_V; pfam02674 632772013402 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 632772013403 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 632772013404 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 632772013405 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 632772013406 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 632772013407 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 632772013408 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772013409 metabolite-proton symporter; Region: 2A0106; TIGR00883 632772013410 putative substrate translocation pore; other site 632772013411 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 632772013412 cyclase homology domain; Region: CHD; cd07302 632772013413 nucleotidyl binding site; other site 632772013414 metal binding site [ion binding]; metal-binding site 632772013415 dimer interface [polypeptide binding]; other site 632772013416 acetyl-CoA synthetase; Provisional; Region: PRK00174 632772013417 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 632772013418 active site 632772013419 CoA binding site [chemical binding]; other site 632772013420 acyl-activating enzyme (AAE) consensus motif; other site 632772013421 AMP binding site [chemical binding]; other site 632772013422 acetate binding site [chemical binding]; other site 632772013423 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 632772013424 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 632772013425 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 632772013426 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772013427 dimer interface [polypeptide binding]; other site 632772013428 conserved gate region; other site 632772013429 putative PBP binding loops; other site 632772013430 ABC-ATPase subunit interface; other site 632772013431 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 632772013432 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772013433 dimer interface [polypeptide binding]; other site 632772013434 conserved gate region; other site 632772013435 putative PBP binding loops; other site 632772013436 ABC-ATPase subunit interface; other site 632772013437 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 632772013438 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 632772013439 Walker A/P-loop; other site 632772013440 ATP binding site [chemical binding]; other site 632772013441 Q-loop/lid; other site 632772013442 ABC transporter signature motif; other site 632772013443 Walker B; other site 632772013444 D-loop; other site 632772013445 H-loop/switch region; other site 632772013446 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 632772013447 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 632772013448 Walker A/P-loop; other site 632772013449 ATP binding site [chemical binding]; other site 632772013450 Q-loop/lid; other site 632772013451 ABC transporter signature motif; other site 632772013452 Walker B; other site 632772013453 D-loop; other site 632772013454 H-loop/switch region; other site 632772013455 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 632772013456 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 632772013457 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632772013458 motif II; other site 632772013459 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 632772013460 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 632772013461 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 632772013462 Walker A motif; other site 632772013463 hexamer interface [polypeptide binding]; other site 632772013464 ATP binding site [chemical binding]; other site 632772013465 Walker B motif; other site 632772013466 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 632772013467 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 632772013468 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772013469 metabolite-proton symporter; Region: 2A0106; TIGR00883 632772013470 putative substrate translocation pore; other site 632772013471 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 632772013472 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 632772013473 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 632772013474 dimerization interface [polypeptide binding]; other site 632772013475 substrate binding pocket [chemical binding]; other site 632772013476 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 632772013477 Coenzyme A transferase; Region: CoA_trans; cl17247 632772013478 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 632772013479 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 632772013480 ATP binding site [chemical binding]; other site 632772013481 putative Mg++ binding site [ion binding]; other site 632772013482 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 632772013483 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 632772013484 DNA-binding site [nucleotide binding]; DNA binding site 632772013485 RNA-binding motif; other site 632772013486 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 632772013487 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 632772013488 active site 632772013489 interdomain interaction site; other site 632772013490 putative metal-binding site [ion binding]; other site 632772013491 nucleotide binding site [chemical binding]; other site 632772013492 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 632772013493 domain I; other site 632772013494 phosphate binding site [ion binding]; other site 632772013495 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 632772013496 domain II; other site 632772013497 domain III; other site 632772013498 nucleotide binding site [chemical binding]; other site 632772013499 DNA binding groove [nucleotide binding] 632772013500 catalytic site [active] 632772013501 domain IV; other site 632772013502 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 632772013503 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 632772013504 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 632772013505 DNA polymerase III subunit delta'; Validated; Region: PRK07940 632772013506 DNA polymerase III subunit delta'; Validated; Region: PRK08485 632772013507 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 632772013508 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 632772013509 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 632772013510 substrate binding pocket [chemical binding]; other site 632772013511 membrane-bound complex binding site; other site 632772013512 hinge residues; other site 632772013513 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772013514 dimer interface [polypeptide binding]; other site 632772013515 conserved gate region; other site 632772013516 putative PBP binding loops; other site 632772013517 ABC-ATPase subunit interface; other site 632772013518 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772013519 dimer interface [polypeptide binding]; other site 632772013520 conserved gate region; other site 632772013521 putative PBP binding loops; other site 632772013522 ABC-ATPase subunit interface; other site 632772013523 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 632772013524 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632772013525 Walker A/P-loop; other site 632772013526 ATP binding site [chemical binding]; other site 632772013527 Q-loop/lid; other site 632772013528 ABC transporter signature motif; other site 632772013529 Walker B; other site 632772013530 D-loop; other site 632772013531 H-loop/switch region; other site 632772013532 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 632772013533 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 632772013534 Transcriptional regulator [Transcription]; Region: LysR; COG0583 632772013535 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 632772013536 LysR substrate binding domain; Region: LysR_substrate; pfam03466 632772013537 dimerization interface [polypeptide binding]; other site 632772013538 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772013539 putative substrate translocation pore; other site 632772013540 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632772013541 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 632772013542 Domain of unknown function (DUF336); Region: DUF336; cl01249 632772013543 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 632772013544 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 632772013545 iron-sulfur cluster [ion binding]; other site 632772013546 [2Fe-2S] cluster binding site [ion binding]; other site 632772013547 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 632772013548 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 632772013549 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 632772013550 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 632772013551 NAD(P) binding site [chemical binding]; other site 632772013552 catalytic residues [active] 632772013553 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 632772013554 [2Fe-2S] cluster binding site [ion binding]; other site 632772013555 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 632772013556 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 632772013557 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 632772013558 homotrimer interaction site [polypeptide binding]; other site 632772013559 putative active site [active] 632772013560 Transcriptional regulators [Transcription]; Region: GntR; COG1802 632772013561 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772013562 DNA-binding site [nucleotide binding]; DNA binding site 632772013563 FCD domain; Region: FCD; pfam07729 632772013564 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772013565 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 632772013566 Zn binding site [ion binding]; other site 632772013567 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772013568 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 632772013569 acyl-activating enzyme (AAE) consensus motif; other site 632772013570 AMP binding site [chemical binding]; other site 632772013571 active site 632772013572 CoA binding site [chemical binding]; other site 632772013573 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772013574 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 632772013575 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 632772013576 putative trimer interface [polypeptide binding]; other site 632772013577 putative CoA binding site [chemical binding]; other site 632772013578 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 632772013579 putative trimer interface [polypeptide binding]; other site 632772013580 putative CoA binding site [chemical binding]; other site 632772013581 YCII-related domain; Region: YCII; cl00999 632772013582 YCII-related domain; Region: YCII; cl00999 632772013583 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 632772013584 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632772013585 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 632772013586 DNA binding residues [nucleotide binding] 632772013587 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 632772013588 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 632772013589 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 632772013590 Predicted amidohydrolase [General function prediction only]; Region: COG0388 632772013591 active site 632772013592 catalytic triad [active] 632772013593 dimer interface [polypeptide binding]; other site 632772013594 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 632772013595 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772013596 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 632772013597 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 632772013598 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772013599 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772013600 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 632772013601 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 632772013602 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 632772013603 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 632772013604 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 632772013605 active site 632772013606 dimer interface [polypeptide binding]; other site 632772013607 metal binding site [ion binding]; metal-binding site 632772013608 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 632772013609 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 632772013610 active site 632772013611 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 632772013612 mce related protein; Region: MCE; pfam02470 632772013613 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 632772013614 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 632772013615 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 632772013616 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 632772013617 catalytic residue [active] 632772013618 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 632772013619 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 632772013620 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 632772013621 putative deacylase active site [active] 632772013622 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 632772013623 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772013624 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 632772013625 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 632772013626 hypothetical protein; Provisional; Region: PRK06185 632772013627 enoyl-CoA hydratase; Provisional; Region: PRK06142 632772013628 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772013629 substrate binding site [chemical binding]; other site 632772013630 oxyanion hole (OAH) forming residues; other site 632772013631 trimer interface [polypeptide binding]; other site 632772013632 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772013633 putative substrate translocation pore; other site 632772013634 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772013635 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 632772013636 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 632772013637 Sulfate transporter family; Region: Sulfate_transp; pfam00916 632772013638 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 632772013639 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772013640 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 632772013641 NAD(P) binding site [chemical binding]; other site 632772013642 active site 632772013643 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 632772013644 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 632772013645 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 632772013646 DXD motif; other site 632772013647 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 632772013648 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 632772013649 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 632772013650 dimer interface [polypeptide binding]; other site 632772013651 substrate binding site [chemical binding]; other site 632772013652 metal binding sites [ion binding]; metal-binding site 632772013653 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 632772013654 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 632772013655 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 632772013656 putative hydrolase; Region: TIGR03624 632772013657 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 632772013658 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 632772013659 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 632772013660 active site 632772013661 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 632772013662 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 632772013663 active site 632772013664 ATP binding site [chemical binding]; other site 632772013665 substrate binding site [chemical binding]; other site 632772013666 activation loop (A-loop); other site 632772013667 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 632772013668 Amidase; Region: Amidase; cl11426 632772013669 FtsH Extracellular; Region: FtsH_ext; pfam06480 632772013670 Poxvirus virion envelope protein A14; Region: Pox_A14; cl17336 632772013671 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 632772013672 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632772013673 Walker A motif; other site 632772013674 ATP binding site [chemical binding]; other site 632772013675 Walker B motif; other site 632772013676 arginine finger; other site 632772013677 Peptidase family M41; Region: Peptidase_M41; pfam01434 632772013678 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 632772013679 homodecamer interface [polypeptide binding]; other site 632772013680 GTP cyclohydrolase I; Provisional; Region: PLN03044 632772013681 active site 632772013682 putative catalytic site residues [active] 632772013683 zinc binding site [ion binding]; other site 632772013684 GTP-CH-I/GFRP interaction surface; other site 632772013685 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 632772013686 dihydropteroate synthase; Region: DHPS; TIGR01496 632772013687 substrate binding pocket [chemical binding]; other site 632772013688 dimer interface [polypeptide binding]; other site 632772013689 inhibitor binding site; inhibition site 632772013690 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 632772013691 homooctamer interface [polypeptide binding]; other site 632772013692 active site 632772013693 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 632772013694 catalytic center binding site [active] 632772013695 ATP binding site [chemical binding]; other site 632772013696 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 632772013697 Uncharacterized conserved protein [Function unknown]; Region: COG5495 632772013698 Rossmann-like domain; Region: Rossmann-like; pfam10727 632772013699 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 632772013700 pantoate--beta-alanine ligase; Region: panC; TIGR00018 632772013701 Pantoate-beta-alanine ligase; Region: PanC; cd00560 632772013702 active site 632772013703 ATP-binding site [chemical binding]; other site 632772013704 pantoate-binding site; other site 632772013705 HXXH motif; other site 632772013706 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 632772013707 tetramerization interface [polypeptide binding]; other site 632772013708 active site 632772013709 pantothenate kinase; Reviewed; Region: PRK13318 632772013710 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 632772013711 Rhodanese Homology Domain; Region: RHOD; smart00450 632772013712 active site residue [active] 632772013713 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 632772013714 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 632772013715 dimer interface [polypeptide binding]; other site 632772013716 putative anticodon binding site; other site 632772013717 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 632772013718 motif 1; other site 632772013719 dimer interface [polypeptide binding]; other site 632772013720 active site 632772013721 motif 2; other site 632772013722 motif 3; other site 632772013723 Lsr2; Region: Lsr2; pfam11774 632772013724 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 632772013725 Lipase (class 2); Region: Lipase_2; pfam01674 632772013726 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 632772013727 Clp amino terminal domain; Region: Clp_N; pfam02861 632772013728 Clp amino terminal domain; Region: Clp_N; pfam02861 632772013729 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632772013730 Walker A motif; other site 632772013731 ATP binding site [chemical binding]; other site 632772013732 Walker B motif; other site 632772013733 arginine finger; other site 632772013734 UvrB/uvrC motif; Region: UVR; pfam02151 632772013735 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632772013736 Walker A motif; other site 632772013737 ATP binding site [chemical binding]; other site 632772013738 Walker B motif; other site 632772013739 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 632772013740 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 632772013741 TIGR03086 family protein; Region: TIGR03086 632772013742 HTH domain; Region: HTH_11; pfam08279 632772013743 WYL domain; Region: WYL; pfam13280 632772013744 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 632772013745 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 632772013746 thiocyanate hydrolase, gamma subunit; Region: thiocyan_alph; TIGR03887 632772013747 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 632772013748 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 632772013749 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 632772013750 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 632772013751 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 632772013752 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 632772013753 catalytic residues [active] 632772013754 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 632772013755 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 632772013756 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 632772013757 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 632772013758 catalytic site [active] 632772013759 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 632772013760 DNA binding residues [nucleotide binding] 632772013761 PIN domain; Region: PIN_3; cl17397 632772013762 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 632772013763 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772013764 S-adenosylmethionine binding site [chemical binding]; other site 632772013765 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 632772013766 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 632772013767 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 632772013768 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 632772013769 homodimer interface [polypeptide binding]; other site 632772013770 substrate-cofactor binding pocket; other site 632772013771 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632772013772 catalytic residue [active] 632772013773 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 632772013774 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632772013775 Walker A/P-loop; other site 632772013776 ATP binding site [chemical binding]; other site 632772013777 Q-loop/lid; other site 632772013778 ABC transporter signature motif; other site 632772013779 Walker B; other site 632772013780 D-loop; other site 632772013781 H-loop/switch region; other site 632772013782 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 632772013783 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632772013784 Walker A/P-loop; other site 632772013785 ATP binding site [chemical binding]; other site 632772013786 Q-loop/lid; other site 632772013787 ABC transporter signature motif; other site 632772013788 Walker B; other site 632772013789 D-loop; other site 632772013790 H-loop/switch region; other site 632772013791 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 632772013792 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 632772013793 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 632772013794 O-methyltransferase; Region: Methyltransf_2; pfam00891 632772013795 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 632772013796 endonuclease III; Region: ENDO3c; smart00478 632772013797 minor groove reading motif; other site 632772013798 helix-hairpin-helix signature motif; other site 632772013799 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 632772013800 active site clefts [active] 632772013801 zinc binding site [ion binding]; other site 632772013802 dimer interface [polypeptide binding]; other site 632772013803 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 632772013804 active site 632772013805 homotetramer interface [polypeptide binding]; other site 632772013806 homodimer interface [polypeptide binding]; other site 632772013807 L-asparagine permease; Provisional; Region: PRK15049 632772013808 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 632772013809 Aspartase; Region: Aspartase; cd01357 632772013810 active sites [active] 632772013811 tetramer interface [polypeptide binding]; other site 632772013812 Transcriptional regulators [Transcription]; Region: FadR; COG2186 632772013813 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772013814 DNA-binding site [nucleotide binding]; DNA binding site 632772013815 FCD domain; Region: FCD; pfam07729 632772013816 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 632772013817 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 632772013818 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 632772013819 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 632772013820 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 632772013821 CoenzymeA binding site [chemical binding]; other site 632772013822 subunit interaction site [polypeptide binding]; other site 632772013823 PHB binding site; other site 632772013824 DNA repair protein RadA; Provisional; Region: PRK11823 632772013825 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 632772013826 Walker A motif; other site 632772013827 ATP binding site [chemical binding]; other site 632772013828 Walker B motif; other site 632772013829 Protein of unknown function (DUF461); Region: DUF461; cl01071 632772013830 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 632772013831 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 632772013832 substrate binding site; other site 632772013833 dimer interface; other site 632772013834 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 632772013835 homotrimer interaction site [polypeptide binding]; other site 632772013836 zinc binding site [ion binding]; other site 632772013837 CDP-binding sites; other site 632772013838 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 632772013839 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 632772013840 active site 632772013841 HIGH motif; other site 632772013842 nucleotide binding site [chemical binding]; other site 632772013843 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 632772013844 KMSKS motif; other site 632772013845 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 632772013846 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 632772013847 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 632772013848 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 632772013849 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 632772013850 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 632772013851 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 632772013852 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 632772013853 hexamer interface [polypeptide binding]; other site 632772013854 ligand binding site [chemical binding]; other site 632772013855 putative active site [active] 632772013856 NAD(P) binding site [chemical binding]; other site 632772013857 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 632772013858 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 632772013859 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 632772013860 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 632772013861 tetrameric interface [polypeptide binding]; other site 632772013862 NAD binding site [chemical binding]; other site 632772013863 catalytic residues [active] 632772013864 hypothetical protein; Provisional; Region: PRK06062 632772013865 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 632772013866 inhibitor-cofactor binding pocket; inhibition site 632772013867 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632772013868 catalytic residue [active] 632772013869 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 632772013870 Amino acid permease; Region: AA_permease_2; pfam13520 632772013871 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 632772013872 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632772013873 putative DNA binding site [nucleotide binding]; other site 632772013874 putative Zn2+ binding site [ion binding]; other site 632772013875 AsnC family; Region: AsnC_trans_reg; pfam01037 632772013876 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 632772013877 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 632772013878 NAD(P) binding site [chemical binding]; other site 632772013879 catalytic residues [active] 632772013880 hypothetical protein; Provisional; Region: PRK06541 632772013881 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 632772013882 inhibitor-cofactor binding pocket; inhibition site 632772013883 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632772013884 catalytic residue [active] 632772013885 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 632772013886 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 632772013887 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 632772013888 active site 632772013889 catalytic site [active] 632772013890 Zn binding site [ion binding]; other site 632772013891 tetramer interface [polypeptide binding]; other site 632772013892 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 632772013893 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 632772013894 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 632772013895 active site 632772013896 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 632772013897 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772013898 NAD(P) binding site [chemical binding]; other site 632772013899 active site 632772013900 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 632772013901 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 632772013902 iron-sulfur cluster [ion binding]; other site 632772013903 [2Fe-2S] cluster binding site [ion binding]; other site 632772013904 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 632772013905 hydrophobic ligand binding site; other site 632772013906 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 632772013907 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 632772013908 FMN-binding pocket [chemical binding]; other site 632772013909 flavin binding motif; other site 632772013910 phosphate binding motif [ion binding]; other site 632772013911 beta-alpha-beta structure motif; other site 632772013912 NAD binding pocket [chemical binding]; other site 632772013913 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 632772013914 catalytic loop [active] 632772013915 iron binding site [ion binding]; other site 632772013916 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 632772013917 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 632772013918 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 632772013919 putative active site [active] 632772013920 PPE family; Region: PPE; pfam00823 632772013921 EspG family; Region: ESX-1_EspG; pfam14011 632772013922 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 632772013923 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 632772013924 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 632772013925 dimer interface [polypeptide binding]; other site 632772013926 putative PBP binding regions; other site 632772013927 ABC-ATPase subunit interface; other site 632772013928 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 632772013929 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632772013930 Walker A/P-loop; other site 632772013931 ATP binding site [chemical binding]; other site 632772013932 Q-loop/lid; other site 632772013933 ABC transporter signature motif; other site 632772013934 Walker B; other site 632772013935 D-loop; other site 632772013936 H-loop/switch region; other site 632772013937 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 632772013938 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 632772013939 intersubunit interface [polypeptide binding]; other site 632772013940 Transcriptional regulators [Transcription]; Region: PurR; COG1609 632772013941 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 632772013942 DNA binding site [nucleotide binding] 632772013943 domain linker motif; other site 632772013944 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 632772013945 putative dimerization interface [polypeptide binding]; other site 632772013946 putative ligand binding site [chemical binding]; other site 632772013947 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 632772013948 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 632772013949 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 632772013950 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 632772013951 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772013952 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772013953 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772013954 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 632772013955 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772013956 active site 632772013957 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772013958 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772013959 active site 632772013960 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772013961 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772013962 active site 632772013963 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772013964 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772013965 active site 632772013966 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 632772013967 active site 632772013968 catalytic site [active] 632772013969 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 632772013970 DUF35 OB-fold domain; Region: DUF35; pfam01796 632772013971 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 632772013972 active site 2 [active] 632772013973 active site 1 [active] 632772013974 lipid-transfer protein; Provisional; Region: PRK07855 632772013975 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 632772013976 active site 632772013977 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 632772013978 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 632772013979 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632772013980 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632772013981 DNA binding residues [nucleotide binding] 632772013982 dimerization interface [polypeptide binding]; other site 632772013983 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632772013984 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 632772013985 Walker A/P-loop; other site 632772013986 ATP binding site [chemical binding]; other site 632772013987 Q-loop/lid; other site 632772013988 ABC transporter signature motif; other site 632772013989 Walker B; other site 632772013990 D-loop; other site 632772013991 H-loop/switch region; other site 632772013992 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 632772013993 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 632772013994 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 632772013995 Ligand binding site; other site 632772013996 metal-binding site 632772013997 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 632772013998 PGAP1-like protein; Region: PGAP1; pfam07819 632772013999 Transcriptional regulator [Transcription]; Region: LysR; COG0583 632772014000 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 632772014001 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 632772014002 dimerization interface [polypeptide binding]; other site 632772014003 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 632772014004 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 632772014005 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 632772014006 nudix motif; other site 632772014007 putative hypoxanthine oxidase; Provisional; Region: PRK09800 632772014008 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 632772014009 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 632772014010 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 632772014011 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 632772014012 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 632772014013 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 632772014014 active site 632772014015 putative substrate binding pocket [chemical binding]; other site 632772014016 urate oxidase; Region: urate_oxi; TIGR03383 632772014017 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 632772014018 active site 632772014019 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 632772014020 active site 632772014021 homotetramer interface [polypeptide binding]; other site 632772014022 putative OHCU decarboxylase; Provisional; Region: PRK13798 632772014023 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 632772014024 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 632772014025 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 632772014026 Na binding site [ion binding]; other site 632772014027 putative substrate binding site [chemical binding]; other site 632772014028 Transcriptional regulators [Transcription]; Region: GntR; COG1802 632772014029 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772014030 DNA-binding site [nucleotide binding]; DNA binding site 632772014031 FCD domain; Region: FCD; pfam07729 632772014032 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 632772014033 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 632772014034 active site 632772014035 catalytic site [active] 632772014036 tetramer interface [polypeptide binding]; other site 632772014037 allantoicase; Provisional; Region: PRK13257 632772014038 Allantoicase repeat; Region: Allantoicase; pfam03561 632772014039 Allantoicase repeat; Region: Allantoicase; pfam03561 632772014040 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 632772014041 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 632772014042 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632772014043 Walker A motif; other site 632772014044 ATP binding site [chemical binding]; other site 632772014045 Walker B motif; other site 632772014046 arginine finger; other site 632772014047 tryptophan synthase subunit beta; Reviewed; Region: PRK12391 632772014048 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 632772014049 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 632772014050 catalytic residue [active] 632772014051 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 632772014052 MoxR-like ATPases [General function prediction only]; Region: COG0714 632772014053 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632772014054 Walker A motif; other site 632772014055 ATP binding site [chemical binding]; other site 632772014056 Walker B motif; other site 632772014057 arginine finger; other site 632772014058 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 632772014059 Protein of unknown function DUF58; Region: DUF58; pfam01882 632772014060 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 632772014061 NlpC/P60 family; Region: NLPC_P60; pfam00877 632772014062 enoyl-CoA hydratase; Region: PLN02864 632772014063 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 632772014064 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 632772014065 dimer interaction site [polypeptide binding]; other site 632772014066 substrate-binding tunnel; other site 632772014067 active site 632772014068 catalytic site [active] 632772014069 substrate binding site [chemical binding]; other site 632772014070 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 632772014071 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 632772014072 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 632772014073 acetaldehyde dehydrogenase; Validated; Region: PRK08300 632772014074 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 632772014075 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 632772014076 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 632772014077 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 632772014078 active site 632772014079 catalytic residues [active] 632772014080 metal binding site [ion binding]; metal-binding site 632772014081 DmpG-like communication domain; Region: DmpG_comm; pfam07836 632772014082 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 632772014083 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 632772014084 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 632772014085 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 632772014086 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 632772014087 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 632772014088 Flavin binding site [chemical binding]; other site 632772014089 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 632772014090 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 632772014091 catalytic site [active] 632772014092 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 632772014093 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 632772014094 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 632772014095 active site 632772014096 Fe binding site [ion binding]; other site 632772014097 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 632772014098 succinic semialdehyde dehydrogenase; Region: PLN02278 632772014099 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 632772014100 tetramerization interface [polypeptide binding]; other site 632772014101 NAD(P) binding site [chemical binding]; other site 632772014102 catalytic residues [active] 632772014103 4-aminobutyrate aminotransferase; Provisional; Region: PRK08117 632772014104 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 632772014105 inhibitor-cofactor binding pocket; inhibition site 632772014106 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632772014107 catalytic residue [active] 632772014108 Protein of unknown function (DUF3830); Region: DUF3830; pfam12903 632772014109 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 632772014110 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 632772014111 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194 632772014112 putative active site [active] 632772014113 metal binding site [ion binding]; metal-binding site 632772014114 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 632772014115 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 632772014116 tetrameric interface [polypeptide binding]; other site 632772014117 NAD binding site [chemical binding]; other site 632772014118 catalytic residues [active] 632772014119 Transcriptional regulator [Transcription]; Region: LysR; COG0583 632772014120 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 632772014121 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 632772014122 dimerization interface [polypeptide binding]; other site 632772014123 Transcriptional regulators [Transcription]; Region: PurR; COG1609 632772014124 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 632772014125 DNA binding site [nucleotide binding] 632772014126 domain linker motif; other site 632772014127 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 632772014128 putative dimerization interface [polypeptide binding]; other site 632772014129 putative ligand binding site [chemical binding]; other site 632772014130 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 632772014131 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 632772014132 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 632772014133 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 632772014134 Metal-binding active site; metal-binding site 632772014135 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 632772014136 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 632772014137 PYR/PP interface [polypeptide binding]; other site 632772014138 dimer interface [polypeptide binding]; other site 632772014139 TPP binding site [chemical binding]; other site 632772014140 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 632772014141 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 632772014142 TPP-binding site [chemical binding]; other site 632772014143 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 632772014144 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 632772014145 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 632772014146 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 632772014147 Aspartase; Region: Aspartase; cd01357 632772014148 active sites [active] 632772014149 tetramer interface [polypeptide binding]; other site 632772014150 histidinol dehydrogenase; Region: hisD; TIGR00069 632772014151 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 632772014152 NAD binding site [chemical binding]; other site 632772014153 dimerization interface [polypeptide binding]; other site 632772014154 product binding site; other site 632772014155 substrate binding site [chemical binding]; other site 632772014156 zinc binding site [ion binding]; other site 632772014157 catalytic residues [active] 632772014158 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 632772014159 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 632772014160 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772014161 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632772014162 putative substrate translocation pore; other site 632772014163 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772014164 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632772014165 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 632772014166 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 632772014167 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 632772014168 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 632772014169 PYR/PP interface [polypeptide binding]; other site 632772014170 dimer interface [polypeptide binding]; other site 632772014171 TPP binding site [chemical binding]; other site 632772014172 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 632772014173 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 632772014174 TPP-binding site [chemical binding]; other site 632772014175 Trehalose utilisation; Region: ThuA; pfam06283 632772014176 Transcriptional regulators [Transcription]; Region: PurR; COG1609 632772014177 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 632772014178 DNA binding site [nucleotide binding] 632772014179 domain linker motif; other site 632772014180 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 632772014181 putative dimerization interface [polypeptide binding]; other site 632772014182 putative ligand binding site [chemical binding]; other site 632772014183 trehalose synthase, Pseudomonas stutzeri type; Region: TreS_stutzeri; TIGR02455 632772014184 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772014185 NADH(P)-binding; Region: NAD_binding_10; pfam13460 632772014186 NAD(P) binding site [chemical binding]; other site 632772014187 active site 632772014188 Rrf2 family protein; Region: rrf2_super; TIGR00738 632772014189 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632772014190 dimerization interface [polypeptide binding]; other site 632772014191 putative Zn2+ binding site [ion binding]; other site 632772014192 putative DNA binding site [nucleotide binding]; other site 632772014193 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 632772014194 Sulfatase; Region: Sulfatase; pfam00884 632772014195 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 632772014196 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632772014197 motif II; other site 632772014198 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 632772014199 Uncharacterized conserved protein [Function unknown]; Region: COG1262 632772014200 Domain of unknown function (DUF202); Region: DUF202; pfam02656 632772014201 putative amidase; Provisional; Region: PRK06169 632772014202 Amidase; Region: Amidase; pfam01425 632772014203 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 632772014204 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 632772014205 NAD binding site [chemical binding]; other site 632772014206 ligand binding site [chemical binding]; other site 632772014207 catalytic site [active] 632772014208 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 632772014209 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 632772014210 Transcriptional regulators [Transcription]; Region: GntR; COG1802 632772014211 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772014212 DNA-binding site [nucleotide binding]; DNA binding site 632772014213 FCD domain; Region: FCD; pfam07729 632772014214 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 632772014215 MarR family; Region: MarR_2; cl17246 632772014216 MarR family; Region: MarR_2; cl17246 632772014217 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 632772014218 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772014219 enoyl-CoA hydratase; Provisional; Region: PRK05862 632772014220 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772014221 substrate binding site [chemical binding]; other site 632772014222 oxyanion hole (OAH) forming residues; other site 632772014223 trimer interface [polypeptide binding]; other site 632772014224 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 632772014225 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772014226 substrate binding site [chemical binding]; other site 632772014227 oxyanion hole (OAH) forming residues; other site 632772014228 trimer interface [polypeptide binding]; other site 632772014229 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 632772014230 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772014231 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 632772014232 substrate binding pocket [chemical binding]; other site 632772014233 FAD binding site [chemical binding]; other site 632772014234 catalytic base [active] 632772014235 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 632772014236 MarR family; Region: MarR_2; pfam12802 632772014237 Transcriptional regulator [Transcription]; Region: LysR; COG0583 632772014238 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 632772014239 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 632772014240 dimerization interface [polypeptide binding]; other site 632772014241 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 632772014242 CoA-transferase family III; Region: CoA_transf_3; pfam02515 632772014243 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 632772014244 Magnetospirillum NAD(P)+-dependent aldehyde dehydrogenase MSR-1-like; Region: ALDH_MGR_2402; cd07108 632772014245 NAD(P) binding site [chemical binding]; other site 632772014246 catalytic residues [active] 632772014247 catalytic residues [active] 632772014248 adenylate kinase; Reviewed; Region: adk; PRK00279 632772014249 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 632772014250 AMP-binding site [chemical binding]; other site 632772014251 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 632772014252 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 632772014253 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 632772014254 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 632772014255 putative hydrophobic ligand binding site [chemical binding]; other site 632772014256 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 632772014257 YCII-related domain; Region: YCII; cl00999 632772014258 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 632772014259 Carboxylesterase family; Region: COesterase; pfam00135 632772014260 substrate binding pocket [chemical binding]; other site 632772014261 catalytic triad [active] 632772014262 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 632772014263 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 632772014264 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632772014265 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 632772014266 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 632772014267 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772014268 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632772014269 putative substrate translocation pore; other site 632772014270 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 632772014271 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 632772014272 Walker A/P-loop; other site 632772014273 ATP binding site [chemical binding]; other site 632772014274 Q-loop/lid; other site 632772014275 ABC transporter signature motif; other site 632772014276 Walker B; other site 632772014277 D-loop; other site 632772014278 H-loop/switch region; other site 632772014279 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 632772014280 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 632772014281 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 632772014282 dimer interface [polypeptide binding]; other site 632772014283 putative PBP binding regions; other site 632772014284 ABC-ATPase subunit interface; other site 632772014285 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 632772014286 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 632772014287 intersubunit interface [polypeptide binding]; other site 632772014288 Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080 632772014289 P-class dimer interface [polypeptide binding]; other site 632772014290 active site 632772014291 Cu2+ binding site [ion binding]; other site 632772014292 Zn2+ binding site [ion binding]; other site 632772014293 Helicase associated domain; Region: HA; pfam03457 632772014294 Helicase associated domain; Region: HA; pfam03457 632772014295 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 632772014296 benzoate transport; Region: 2A0115; TIGR00895 632772014297 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772014298 putative substrate translocation pore; other site 632772014299 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772014300 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 632772014301 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772014302 acyl-activating enzyme (AAE) consensus motif; other site 632772014303 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772014304 AMP binding site [chemical binding]; other site 632772014305 active site 632772014306 acyl-activating enzyme (AAE) consensus motif; other site 632772014307 CoA binding site [chemical binding]; other site 632772014308 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 632772014309 DUF35 OB-fold domain; Region: DUF35; pfam01796 632772014310 lipid-transfer protein; Provisional; Region: PRK07855 632772014311 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 632772014312 active site 632772014313 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 632772014314 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772014315 putative substrate translocation pore; other site 632772014316 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 632772014317 homotrimer interaction site [polypeptide binding]; other site 632772014318 putative active site [active] 632772014319 Membrane dipeptidase (Peptidase family M19); Region: Peptidase_M19; pfam01244 632772014320 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 632772014321 active site 632772014322 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 632772014323 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 632772014324 NAD(P) binding site [chemical binding]; other site 632772014325 catalytic residues [active] 632772014326 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 632772014327 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 632772014328 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 632772014329 dimerization interface [polypeptide binding]; other site 632772014330 substrate binding pocket [chemical binding]; other site 632772014331 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 632772014332 short chain dehydrogenase; Provisional; Region: PRK07677 632772014333 classical (c) SDRs; Region: SDR_c; cd05233 632772014334 NAD(P) binding site [chemical binding]; other site 632772014335 active site 632772014336 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 632772014337 Cytochrome P450; Region: p450; cl12078 632772014338 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 632772014339 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 632772014340 active site 632772014341 catalytic tetrad [active] 632772014342 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 632772014343 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632772014344 active site 632772014345 motif I; other site 632772014346 motif II; other site 632772014347 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 632772014348 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 632772014349 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 632772014350 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 632772014351 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772014352 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772014353 active site 632772014354 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772014355 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772014356 active site 632772014357 enoyl-CoA hydratase; Provisional; Region: PRK08290 632772014358 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772014359 substrate binding site [chemical binding]; other site 632772014360 oxyanion hole (OAH) forming residues; other site 632772014361 trimer interface [polypeptide binding]; other site 632772014362 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 632772014363 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772014364 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 632772014365 acyl-activating enzyme (AAE) consensus motif; other site 632772014366 putative AMP binding site [chemical binding]; other site 632772014367 putative active site [active] 632772014368 putative CoA binding site [chemical binding]; other site 632772014369 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 632772014370 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 632772014371 FAD binding site [chemical binding]; other site 632772014372 substrate binding site [chemical binding]; other site 632772014373 catalytic base [active] 632772014374 short chain dehydrogenase; Provisional; Region: PRK07831 632772014375 classical (c) SDRs; Region: SDR_c; cd05233 632772014376 NAD(P) binding site [chemical binding]; other site 632772014377 active site 632772014378 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772014379 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772014380 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 632772014381 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 632772014382 dimer interface [polypeptide binding]; other site 632772014383 active site 632772014384 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 632772014385 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 632772014386 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 632772014387 putative active site [active] 632772014388 putative NTP binding site [chemical binding]; other site 632772014389 putative nucleic acid binding site [nucleotide binding]; other site 632772014390 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 632772014391 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 632772014392 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 632772014393 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 632772014394 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 632772014395 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 632772014396 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 632772014397 NifU-like domain; Region: NifU; cl00484 632772014398 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 632772014399 [2Fe-2S] cluster binding site [ion binding]; other site 632772014400 iron-sulfur cluster [ion binding]; other site 632772014401 Putative [NiFe] hydrogenase-specific C-terminal protease. Sequence comparison shows similarity to hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). Maturation of [FeNi] hydrogenases includes formation of...; Region: H2MP_like-1; cd06068 632772014402 nickel binding site [ion binding]; other site 632772014403 HupF/HypC family; Region: HupF_HypC; pfam01455 632772014404 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 632772014405 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772014406 NAD(P) binding site [chemical binding]; other site 632772014407 active site 632772014408 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 632772014409 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772014410 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 632772014411 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 632772014412 Hemerythrin-like domain; Region: Hr-like; cd12108 632772014413 Fe binding site [ion binding]; other site 632772014414 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 632772014415 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772014416 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 632772014417 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 632772014418 NAD binding site [chemical binding]; other site 632772014419 catalytic residues [active] 632772014420 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 632772014421 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 632772014422 catalytic Zn binding site [ion binding]; other site 632772014423 NAD binding site [chemical binding]; other site 632772014424 structural Zn binding site [ion binding]; other site 632772014425 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 632772014426 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 632772014427 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 632772014428 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 632772014429 Cytochrome P450; Region: p450; cl12078 632772014430 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 632772014431 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 632772014432 catalytic loop [active] 632772014433 iron binding site [ion binding]; other site 632772014434 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632772014435 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632772014436 DNA binding residues [nucleotide binding] 632772014437 dimerization interface [polypeptide binding]; other site 632772014438 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632772014439 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632772014440 DNA binding residues [nucleotide binding] 632772014441 dimerization interface [polypeptide binding]; other site 632772014442 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772014443 enoyl-CoA hydratase; Provisional; Region: PRK06688 632772014444 substrate binding site [chemical binding]; other site 632772014445 oxyanion hole (OAH) forming residues; other site 632772014446 trimer interface [polypeptide binding]; other site 632772014447 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 632772014448 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 632772014449 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 632772014450 acyl-activating enzyme (AAE) consensus motif; other site 632772014451 putative AMP binding site [chemical binding]; other site 632772014452 putative active site [active] 632772014453 putative CoA binding site [chemical binding]; other site 632772014454 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 632772014455 active site 2 [active] 632772014456 active site 1 [active] 632772014457 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 632772014458 active site 632772014459 catalytic site [active] 632772014460 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772014461 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772014462 active site 632772014463 acetyl-CoA synthetase; Provisional; Region: PRK00174 632772014464 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 632772014465 Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; Region: AACS_like; cd05968 632772014466 acyl-activating enzyme (AAE) consensus motif; other site 632772014467 putative AMP binding site [chemical binding]; other site 632772014468 putative active site [active] 632772014469 putative CoA binding site [chemical binding]; other site 632772014470 Transcriptional regulators [Transcription]; Region: FadR; COG2186 632772014471 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772014472 DNA-binding site [nucleotide binding]; DNA binding site 632772014473 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 632772014474 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772014475 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 632772014476 active site 632772014477 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772014478 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772014479 active site 632772014480 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 632772014481 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772014482 NAD(P) binding site [chemical binding]; other site 632772014483 active site 632772014484 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 632772014485 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 632772014486 dimer interface [polypeptide binding]; other site 632772014487 active site 632772014488 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 632772014489 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 632772014490 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 632772014491 active site 632772014492 catalytic residues [active] 632772014493 metal binding site [ion binding]; metal-binding site 632772014494 2-hydroxycyclohexanecarboxyl-CoA dehydrogenase; Region: benzo_BadH; TIGR03206 632772014495 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772014496 NAD(P) binding site [chemical binding]; other site 632772014497 active site 632772014498 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772014499 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 632772014500 substrate binding site [chemical binding]; other site 632772014501 oxyanion hole (OAH) forming residues; other site 632772014502 trimer interface [polypeptide binding]; other site 632772014503 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772014504 enoyl-CoA hydratase; Provisional; Region: PRK07658 632772014505 substrate binding site [chemical binding]; other site 632772014506 oxyanion hole (OAH) forming residues; other site 632772014507 trimer interface [polypeptide binding]; other site 632772014508 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 632772014509 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 632772014510 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 632772014511 CoA-transferase family III; Region: CoA_transf_3; pfam02515 632772014512 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772014513 enoyl-CoA hydratase; Provisional; Region: PRK09245 632772014514 substrate binding site [chemical binding]; other site 632772014515 oxyanion hole (OAH) forming residues; other site 632772014516 trimer interface [polypeptide binding]; other site 632772014517 enoyl-CoA hydratase; Provisional; Region: PRK06688 632772014518 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772014519 substrate binding site [chemical binding]; other site 632772014520 oxyanion hole (OAH) forming residues; other site 632772014521 trimer interface [polypeptide binding]; other site 632772014522 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 632772014523 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 632772014524 Phosphotransferase enzyme family; Region: APH; pfam01636 632772014525 putative active site [active] 632772014526 putative substrate binding site [chemical binding]; other site 632772014527 ATP binding site [chemical binding]; other site 632772014528 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772014529 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772014530 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 632772014531 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772014532 CoA binding site [chemical binding]; other site 632772014533 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 632772014534 subunit interaction site [polypeptide binding]; other site 632772014535 PHB binding site; other site 632772014536 CoenzymeA binding site [chemical binding]; other site 632772014537 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 632772014538 CoenzymeA binding site [chemical binding]; other site 632772014539 subunit interaction site [polypeptide binding]; other site 632772014540 PHB binding site; other site 632772014541 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 632772014542 NAD(P) binding site [chemical binding]; other site 632772014543 short chain dehydrogenase; Provisional; Region: PRK07677 632772014544 substrate binding site [chemical binding]; other site 632772014545 homotetramer interface [polypeptide binding]; other site 632772014546 active site 632772014547 homodimer interface [polypeptide binding]; other site 632772014548 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772014549 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772014550 active site 632772014551 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772014552 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 632772014553 substrate binding site [chemical binding]; other site 632772014554 oxyanion hole (OAH) forming residues; other site 632772014555 trimer interface [polypeptide binding]; other site 632772014556 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 632772014557 putative active site [active] 632772014558 putative substrate binding site [chemical binding]; other site 632772014559 ATP binding site [chemical binding]; other site 632772014560 Phosphotransferase enzyme family; Region: APH; pfam01636 632772014561 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772014562 metabolite-proton symporter; Region: 2A0106; TIGR00883 632772014563 putative substrate translocation pore; other site 632772014564 Transcriptional regulator [Transcription]; Region: IclR; COG1414 632772014565 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 632772014566 Bacterial transcriptional regulator; Region: IclR; pfam01614 632772014567 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 632772014568 active site 632772014569 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772014570 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772014571 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632772014572 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772014573 putative substrate translocation pore; other site 632772014574 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772014575 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 632772014576 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 632772014577 active site 632772014578 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 632772014579 putative active site [active] 632772014580 putative catalytic site [active] 632772014581 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 632772014582 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 632772014583 NAD(P) binding site [chemical binding]; other site 632772014584 Phosphotransferase enzyme family; Region: APH; pfam01636 632772014585 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 632772014586 putative active site [active] 632772014587 putative substrate binding site [chemical binding]; other site 632772014588 ATP binding site [chemical binding]; other site 632772014589 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 632772014590 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772014591 NAD(P) binding site [chemical binding]; other site 632772014592 active site 632772014593 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772014594 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 632772014595 NAD(P) binding site [chemical binding]; other site 632772014596 active site 632772014597 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 632772014598 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 632772014599 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 632772014600 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 632772014601 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772014602 acyl-activating enzyme (AAE) consensus motif; other site 632772014603 AMP binding site [chemical binding]; other site 632772014604 active site 632772014605 CoA binding site [chemical binding]; other site 632772014606 FAD binding domain; Region: FAD_binding_3; pfam01494 632772014607 hypothetical protein; Provisional; Region: PRK07236 632772014608 hypothetical protein; Provisional; Region: PRK07236 632772014609 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 632772014610 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 632772014611 The single-domain 2,3-dihydroxybiphenyl 1,2-dioxygenases (BphC, EC 1.13.11.39) from Rhodococcus globerulus P6, BphC2-RGP6 and BphC3-RGP6, and similar proteins; Region: BphC2-C3-RGP6_C_like; cd08348 632772014612 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 632772014613 putative active site [active] 632772014614 putative metal binding site [ion binding]; other site 632772014615 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 632772014616 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 632772014617 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 632772014618 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 632772014619 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 632772014620 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772014621 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772014622 active site 632772014623 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 632772014624 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 632772014625 dimer interface [polypeptide binding]; other site 632772014626 SnoaL-like domain; Region: SnoaL_2; pfam12680 632772014627 short chain dehydrogenase; Provisional; Region: PRK05867 632772014628 classical (c) SDRs; Region: SDR_c; cd05233 632772014629 NAD(P) binding site [chemical binding]; other site 632772014630 active site 632772014631 6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase, N-benzyl-3-pyrrolidinol dehydrogenase, and other MDR family members; Region: hydroxyacyl_CoA_DH; cd08254 632772014632 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 632772014633 putative NAD(P) binding site [chemical binding]; other site 632772014634 catalytic Zn binding site [ion binding]; other site 632772014635 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772014636 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 632772014637 NAD(P) binding site [chemical binding]; other site 632772014638 active site 632772014639 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 632772014640 [2Fe-2S] cluster binding site [ion binding]; other site 632772014641 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 632772014642 inter-subunit interface; other site 632772014643 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 632772014644 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 632772014645 [2Fe-2S] cluster binding site [ion binding]; other site 632772014646 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 632772014647 putative alpha subunit interface [polypeptide binding]; other site 632772014648 putative active site [active] 632772014649 putative substrate binding site [chemical binding]; other site 632772014650 Fe binding site [ion binding]; other site 632772014651 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 632772014652 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 632772014653 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772014654 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 632772014655 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 632772014656 Amidohydrolase; Region: Amidohydro_2; pfam04909 632772014657 Transcriptional regulator [Transcription]; Region: IclR; COG1414 632772014658 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 632772014659 Bacterial transcriptional regulator; Region: IclR; pfam01614 632772014660 Subunit B of the Class III Extradiol dioxygenase, Protocatechuate 4,5-dioxygenase, and simlar enzymes; Region: PCA_45_Doxase_B_like; cd07359 632772014661 active site 632772014662 Fe(II) binding site [ion binding]; other site 632772014663 dimer interface [polypeptide binding]; other site 632772014664 tetramer interface [polypeptide binding]; other site 632772014665 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 632772014666 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 632772014667 Bacterial transcriptional regulator; Region: IclR; pfam01614 632772014668 metabolite-proton symporter; Region: 2A0106; TIGR00883 632772014669 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772014670 putative substrate translocation pore; other site 632772014671 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 632772014672 CoA-transferase family III; Region: CoA_transf_3; pfam02515 632772014673 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772014674 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772014675 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 632772014676 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772014677 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 632772014678 NAD(P) binding site [chemical binding]; other site 632772014679 active site 632772014680 short chain dehydrogenase; Provisional; Region: PRK07454 632772014681 classical (c) SDRs; Region: SDR_c; cd05233 632772014682 NAD(P) binding site [chemical binding]; other site 632772014683 active site 632772014684 acetyl-CoA acetyltransferase; Provisional; Region: PRK06504 632772014685 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 632772014686 dimer interface [polypeptide binding]; other site 632772014687 active site 632772014688 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 632772014689 DUF35 OB-fold domain; Region: DUF35; pfam01796 632772014690 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 632772014691 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 632772014692 active site 632772014693 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 632772014694 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 632772014695 putative active site [active] 632772014696 putative catalytic site [active] 632772014697 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772014698 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772014699 active site 632772014700 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 632772014701 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772014702 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772014703 active site 632772014704 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 632772014705 classical (c) SDRs; Region: SDR_c; cd05233 632772014706 NAD(P) binding site [chemical binding]; other site 632772014707 active site 632772014708 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 632772014709 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772014710 NAD(P) binding site [chemical binding]; other site 632772014711 active site 632772014712 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 632772014713 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 632772014714 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 632772014715 dimerization interface [polypeptide binding]; other site 632772014716 active site 632772014717 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 632772014718 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 632772014719 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 632772014720 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772014721 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 632772014722 active site 632772014723 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 632772014724 active site 632772014725 catalytic site [active] 632772014726 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772014727 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 632772014728 acyl-activating enzyme (AAE) consensus motif; other site 632772014729 AMP binding site [chemical binding]; other site 632772014730 active site 632772014731 CoA binding site [chemical binding]; other site 632772014732 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 632772014733 classical (c) SDRs; Region: SDR_c; cd05233 632772014734 NAD(P) binding site [chemical binding]; other site 632772014735 active site 632772014736 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 632772014737 CoA-transferase family III; Region: CoA_transf_3; pfam02515 632772014738 metabolite-proton symporter; Region: 2A0106; TIGR00883 632772014739 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772014740 putative substrate translocation pore; other site 632772014741 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 632772014742 classical (c) SDRs; Region: SDR_c; cd05233 632772014743 NAD(P) binding site [chemical binding]; other site 632772014744 active site 632772014745 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 632772014746 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 632772014747 Phosphotransferase enzyme family; Region: APH; pfam01636 632772014748 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 632772014749 putative active site [active] 632772014750 ATP binding site [chemical binding]; other site 632772014751 putative substrate binding site [chemical binding]; other site 632772014752 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 632772014753 classical (c) SDRs; Region: SDR_c; cd05233 632772014754 NAD(P) binding site [chemical binding]; other site 632772014755 active site 632772014756 cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207 632772014757 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 632772014758 active site 632772014759 Transcriptional regulators [Transcription]; Region: MarR; COG1846 632772014760 MarR family; Region: MarR; pfam01047 632772014761 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 632772014762 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 632772014763 NAD(P) binding site [chemical binding]; other site 632772014764 GAF domain; Region: GAF; cl17456 632772014765 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632772014766 DNA binding residues [nucleotide binding] 632772014767 dimerization interface [polypeptide binding]; other site 632772014768 GAF domain; Region: GAF; cl17456 632772014769 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632772014770 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632772014771 DNA binding residues [nucleotide binding] 632772014772 dimerization interface [polypeptide binding]; other site 632772014773 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 632772014774 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 632772014775 catalytic loop [active] 632772014776 iron binding site [ion binding]; other site 632772014777 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 632772014778 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 632772014779 acyl-activating enzyme (AAE) consensus motif; other site 632772014780 putative AMP binding site [chemical binding]; other site 632772014781 putative active site [active] 632772014782 putative CoA binding site [chemical binding]; other site 632772014783 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 632772014784 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 632772014785 NAD binding site [chemical binding]; other site 632772014786 catalytic residues [active] 632772014787 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 632772014788 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 632772014789 Walker A/P-loop; other site 632772014790 ATP binding site [chemical binding]; other site 632772014791 Q-loop/lid; other site 632772014792 ABC transporter signature motif; other site 632772014793 Walker B; other site 632772014794 D-loop; other site 632772014795 H-loop/switch region; other site 632772014796 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 632772014797 mce related protein; Region: MCE; pfam02470 632772014798 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 632772014799 mce related protein; Region: MCE; pfam02470 632772014800 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 632772014801 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 632772014802 mce related protein; Region: MCE; pfam02470 632772014803 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 632772014804 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 632772014805 mce related protein; Region: MCE; pfam02470 632772014806 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 632772014807 mce related protein; Region: MCE; pfam02470 632772014808 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 632772014809 mce related protein; Region: MCE; pfam02470 632772014810 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 632772014811 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 632772014812 Permease; Region: Permease; pfam02405 632772014813 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 632772014814 Permease; Region: Permease; pfam02405 632772014815 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 632772014816 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 632772014817 catalytic Zn binding site [ion binding]; other site 632772014818 NAD binding site [chemical binding]; other site 632772014819 structural Zn binding site [ion binding]; other site 632772014820 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 632772014821 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 632772014822 N-acetyl-D-glucosamine binding site [chemical binding]; other site 632772014823 catalytic residue [active] 632772014824 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 632772014825 NlpC/P60 family; Region: NLPC_P60; pfam00877 632772014826 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 632772014827 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 632772014828 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 632772014829 catalytic loop [active] 632772014830 iron binding site [ion binding]; other site 632772014831 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 632772014832 Cytochrome P450; Region: p450; cl12078 632772014833 Secretory lipase; Region: LIP; pfam03583 632772014834 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 632772014835 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 632772014836 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 632772014837 heme-binding site [chemical binding]; other site 632772014838 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 632772014839 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 632772014840 FAD binding pocket [chemical binding]; other site 632772014841 FAD binding motif [chemical binding]; other site 632772014842 phosphate binding motif [ion binding]; other site 632772014843 beta-alpha-beta structure motif; other site 632772014844 NAD binding pocket [chemical binding]; other site 632772014845 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 632772014846 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 632772014847 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 632772014848 active site 632772014849 catalytic tetrad [active] 632772014850 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 632772014851 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 632772014852 Walker A/P-loop; other site 632772014853 ATP binding site [chemical binding]; other site 632772014854 Q-loop/lid; other site 632772014855 ABC transporter signature motif; other site 632772014856 Walker B; other site 632772014857 D-loop; other site 632772014858 H-loop/switch region; other site 632772014859 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 632772014860 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 632772014861 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 632772014862 Walker A/P-loop; other site 632772014863 ATP binding site [chemical binding]; other site 632772014864 Q-loop/lid; other site 632772014865 ABC transporter signature motif; other site 632772014866 Walker B; other site 632772014867 D-loop; other site 632772014868 H-loop/switch region; other site 632772014869 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 632772014870 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 632772014871 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772014872 dimer interface [polypeptide binding]; other site 632772014873 conserved gate region; other site 632772014874 ABC-ATPase subunit interface; other site 632772014875 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 632772014876 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772014877 dimer interface [polypeptide binding]; other site 632772014878 conserved gate region; other site 632772014879 putative PBP binding loops; other site 632772014880 ABC-ATPase subunit interface; other site 632772014881 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 632772014882 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 632772014883 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 632772014884 BNR repeat-like domain; Region: BNR_2; pfam13088 632772014885 short chain dehydrogenase; Provisional; Region: PRK07577 632772014886 classical (c) SDRs; Region: SDR_c; cd05233 632772014887 NAD(P) binding site [chemical binding]; other site 632772014888 active site 632772014889 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 632772014890 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 632772014891 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 632772014892 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 632772014893 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 632772014894 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 632772014895 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 632772014896 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 632772014897 HupF/HypC family; Region: HupF_HypC; pfam01455 632772014898 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 632772014899 dimerization interface [polypeptide binding]; other site 632772014900 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 632772014901 ATP binding site [chemical binding]; other site 632772014902 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 632772014903 dimer interface [polypeptide binding]; other site 632772014904 active site 632772014905 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 632772014906 HupF/HypC family; Region: HupF_HypC; cl00394 632772014907 Acylphosphatase; Region: Acylphosphatase; pfam00708 632772014908 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 632772014909 HypF finger; Region: zf-HYPF; pfam07503 632772014910 HypF finger; Region: zf-HYPF; pfam07503 632772014911 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 632772014912 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 632772014913 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 632772014914 active site 632772014915 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 632772014916 salt bridge; other site 632772014917 non-specific DNA binding site [nucleotide binding]; other site 632772014918 sequence-specific DNA binding site [nucleotide binding]; other site 632772014919 hydroxyglutarate oxidase; Provisional; Region: PRK11728 632772014920 Predicted dehydrogenase [General function prediction only]; Region: COG0579 632772014921 Cytochrome P450; Region: p450; pfam00067 632772014922 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 632772014923 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772014924 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772014925 aldolase II superfamily protein; Provisional; Region: PRK07044 632772014926 intersubunit interface [polypeptide binding]; other site 632772014927 active site 632772014928 Zn2+ binding site [ion binding]; other site 632772014929 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299 632772014930 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 632772014931 ligand binding site [chemical binding]; other site 632772014932 NAD binding site [chemical binding]; other site 632772014933 catalytic site [active] 632772014934 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 632772014935 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772014936 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 632772014937 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479 632772014938 Na binding site [ion binding]; other site 632772014939 Transcriptional regulator [Transcription]; Region: LysR; COG0583 632772014940 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 632772014941 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 632772014942 dimerization interface [polypeptide binding]; other site 632772014943 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 632772014944 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 632772014945 Bacterial transcriptional regulator; Region: IclR; pfam01614 632772014946 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 632772014947 CoA-transferase family III; Region: CoA_transf_3; pfam02515 632772014948 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772014949 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772014950 active site 632772014951 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 632772014952 DNA-binding site [nucleotide binding]; DNA binding site 632772014953 RNA-binding motif; other site 632772014954 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 632772014955 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 632772014956 putative active site [active] 632772014957 putative metal binding site [ion binding]; other site 632772014958 imidazolonepropionase; Provisional; Region: PRK14085 632772014959 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 632772014960 active site 632772014961 urocanate hydratase; Provisional; Region: PRK05414 632772014962 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 632772014963 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 632772014964 Na binding site [ion binding]; other site 632772014965 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 632772014966 BsuBI/PstI restriction endonuclease C-terminus; Region: BsuBI_PstI_RE; pfam06616 632772014967 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 632772014968 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772014969 DNA-binding site [nucleotide binding]; DNA binding site 632772014970 UTRA domain; Region: UTRA; pfam07702 632772014971 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 632772014972 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 632772014973 Helix-turn-helix domain; Region: HTH_18; pfam12833 632772014974 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 632772014975 Beta-lactamase; Region: Beta-lactamase; pfam00144 632772014976 Nitronate monooxygenase; Region: NMO; pfam03060 632772014977 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 632772014978 FMN binding site [chemical binding]; other site 632772014979 substrate binding site [chemical binding]; other site 632772014980 putative catalytic residue [active] 632772014981 Coenzyme A transferase; Region: CoA_trans; cl17247 632772014982 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 632772014983 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772014984 enoyl-CoA hydratase; Provisional; Region: PRK06495 632772014985 substrate binding site [chemical binding]; other site 632772014986 oxyanion hole (OAH) forming residues; other site 632772014987 trimer interface [polypeptide binding]; other site 632772014988 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 632772014989 classical (c) SDRs; Region: SDR_c; cd05233 632772014990 NAD(P) binding site [chemical binding]; other site 632772014991 active site 632772014992 short chain dehydrogenase; Provisional; Region: PRK07791 632772014993 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772014994 NAD(P) binding site [chemical binding]; other site 632772014995 active site 632772014996 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 632772014997 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 632772014998 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 632772014999 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 632772015000 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772015001 S-adenosylmethionine binding site [chemical binding]; other site 632772015002 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 632772015003 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 632772015004 Methyltransferase domain; Region: Methyltransf_24; pfam13578 632772015005 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 632772015006 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 632772015007 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 632772015008 short chain dehydrogenase; Provisional; Region: PRK07774 632772015009 classical (c) SDRs; Region: SDR_c; cd05233 632772015010 NAD(P) binding site [chemical binding]; other site 632772015011 active site 632772015012 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 632772015013 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 632772015014 NAD binding site [chemical binding]; other site 632772015015 catalytic residues [active] 632772015016 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 632772015017 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 632772015018 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 632772015019 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 632772015020 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772015021 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772015022 WHG domain; Region: WHG; pfam13305 632772015023 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 632772015024 Cytochrome P450; Region: p450; cl12078 632772015025 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772015026 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772015027 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 632772015028 Cytochrome P450; Region: p450; cl12078 632772015029 short chain dehydrogenase; Provisional; Region: PRK07775 632772015030 classical (c) SDRs; Region: SDR_c; cd05233 632772015031 NAD(P) binding site [chemical binding]; other site 632772015032 active site 632772015033 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 632772015034 Cytochrome P450; Region: p450; cl12078 632772015035 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 632772015036 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 632772015037 acyl-CoA synthetase; Validated; Region: PRK07798 632772015038 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772015039 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 632772015040 acyl-activating enzyme (AAE) consensus motif; other site 632772015041 acyl-activating enzyme (AAE) consensus motif; other site 632772015042 putative AMP binding site [chemical binding]; other site 632772015043 putative active site [active] 632772015044 putative CoA binding site [chemical binding]; other site 632772015045 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 632772015046 primary dimer interface [polypeptide binding]; other site 632772015047 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 632772015048 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 632772015049 Coenzyme A binding pocket [chemical binding]; other site 632772015050 Domain of unknown function (DUF385); Region: DUF385; pfam04075 632772015051 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 632772015052 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 632772015053 dimer interface [polypeptide binding]; other site 632772015054 active site 632772015055 Cytochrome P450; Region: p450; cl12078 632772015056 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 632772015057 Uncharacterized conserved protein [Function unknown]; Region: COG0397 632772015058 hypothetical protein; Validated; Region: PRK00029 632772015059 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 632772015060 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 632772015061 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 632772015062 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 632772015063 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 632772015064 active site 632772015065 lipid-transfer protein; Provisional; Region: PRK07937 632772015066 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 632772015067 active site 632772015068 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 632772015069 DUF35 OB-fold domain; Region: DUF35; pfam01796 632772015070 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 632772015071 DUF35 OB-fold domain; Region: DUF35; pfam01796 632772015072 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 632772015073 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 632772015074 enoyl-CoA hydratase; Provisional; Region: PRK07799 632772015075 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772015076 substrate binding site [chemical binding]; other site 632772015077 oxyanion hole (OAH) forming residues; other site 632772015078 trimer interface [polypeptide binding]; other site 632772015079 acyl-CoA synthetase; Validated; Region: PRK07798 632772015080 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772015081 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 632772015082 acyl-activating enzyme (AAE) consensus motif; other site 632772015083 acyl-activating enzyme (AAE) consensus motif; other site 632772015084 putative AMP binding site [chemical binding]; other site 632772015085 putative active site [active] 632772015086 putative CoA binding site [chemical binding]; other site 632772015087 Nitronate monooxygenase; Region: NMO; pfam03060 632772015088 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 632772015089 FMN binding site [chemical binding]; other site 632772015090 substrate binding site [chemical binding]; other site 632772015091 putative catalytic residue [active] 632772015092 acyl-CoA synthetase; Validated; Region: PRK07867 632772015093 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772015094 acyl-activating enzyme (AAE) consensus motif; other site 632772015095 AMP binding site [chemical binding]; other site 632772015096 active site 632772015097 CoA binding site [chemical binding]; other site 632772015098 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772015099 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 632772015100 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 632772015101 active site 632772015102 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772015103 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 632772015104 FAD binding site [chemical binding]; other site 632772015105 substrate binding site [chemical binding]; other site 632772015106 catalytic base [active] 632772015107 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 632772015108 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 632772015109 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 632772015110 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772015111 NAD(P) binding site [chemical binding]; other site 632772015112 active site 632772015113 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 632772015114 Permease; Region: Permease; pfam02405 632772015115 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 632772015116 Permease; Region: Permease; pfam02405 632772015117 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 632772015118 mce related protein; Region: MCE; pfam02470 632772015119 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 632772015120 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 632772015121 mce related protein; Region: MCE; pfam02470 632772015122 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 632772015123 mce related protein; Region: MCE; pfam02470 632772015124 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 632772015125 mce related protein; Region: MCE; pfam02470 632772015126 Tail length tape measure protein; Region: Phage_HK97_TLTM; pfam06120 632772015127 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 632772015128 mce related protein; Region: MCE; pfam02470 632772015129 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 632772015130 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 632772015131 mce related protein; Region: MCE; pfam02470 632772015132 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 632772015133 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772015134 NAD(P) binding site [chemical binding]; other site 632772015135 active site 632772015136 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 632772015137 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 632772015138 active site 632772015139 homotetramer interface [polypeptide binding]; other site 632772015140 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 632772015141 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632772015142 Walker A/P-loop; other site 632772015143 ATP binding site [chemical binding]; other site 632772015144 Q-loop/lid; other site 632772015145 ABC transporter signature motif; other site 632772015146 Walker B; other site 632772015147 D-loop; other site 632772015148 H-loop/switch region; other site 632772015149 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 632772015150 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632772015151 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 632772015152 Walker A/P-loop; other site 632772015153 ATP binding site [chemical binding]; other site 632772015154 Q-loop/lid; other site 632772015155 ABC transporter signature motif; other site 632772015156 Walker B; other site 632772015157 D-loop; other site 632772015158 H-loop/switch region; other site 632772015159 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 632772015160 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 632772015161 active site 632772015162 substrate binding site [chemical binding]; other site 632772015163 cosubstrate binding site; other site 632772015164 catalytic site [active] 632772015165 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 632772015166 active site 632772015167 hexamer interface [polypeptide binding]; other site 632772015168 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 632772015169 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 632772015170 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 632772015171 PAS fold; Region: PAS_3; pfam08447 632772015172 PAS fold; Region: PAS_4; pfam08448 632772015173 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 632772015174 putative active site [active] 632772015175 heme pocket [chemical binding]; other site 632772015176 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 632772015177 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 632772015178 metal binding site [ion binding]; metal-binding site 632772015179 active site 632772015180 I-site; other site 632772015181 Condensation domain; Region: Condensation; pfam00668 632772015182 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772015183 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 632772015184 acyl-activating enzyme (AAE) consensus motif; other site 632772015185 AMP binding site [chemical binding]; other site 632772015186 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772015187 Condensation domain; Region: Condensation; pfam00668 632772015188 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 632772015189 Condensation domain; Region: Condensation; pfam00668 632772015190 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 632772015191 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772015192 acyl-activating enzyme (AAE) consensus motif; other site 632772015193 AMP binding site [chemical binding]; other site 632772015194 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772015195 Condensation domain; Region: Condensation; pfam00668 632772015196 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 632772015197 Condensation domain; Region: Condensation; pfam00668 632772015198 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 632772015199 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772015200 acyl-activating enzyme (AAE) consensus motif; other site 632772015201 AMP binding site [chemical binding]; other site 632772015202 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772015203 Condensation domain; Region: Condensation; pfam00668 632772015204 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 632772015205 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772015206 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772015207 acyl-activating enzyme (AAE) consensus motif; other site 632772015208 AMP binding site [chemical binding]; other site 632772015209 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772015210 Condensation domain; Region: Condensation; pfam00668 632772015211 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 632772015212 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772015213 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 632772015214 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 632772015215 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 632772015216 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 632772015217 Uncharacterized conserved protein [Function unknown]; Region: COG2966 632772015218 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 632772015219 Uncharacterized conserved protein [Function unknown]; Region: COG3610 632772015220 Secretory lipase; Region: LIP; pfam03583 632772015221 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772015222 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772015223 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 632772015224 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 632772015225 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 632772015226 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632772015227 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 632772015228 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 632772015229 DNA binding residues [nucleotide binding] 632772015230 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 632772015231 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 632772015232 DNA binding residues [nucleotide binding] 632772015233 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 632772015234 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 632772015235 DNA binding residues [nucleotide binding] 632772015236 putative dimer interface [polypeptide binding]; other site 632772015237 potential frameshift: common BLAST hit: gi|182434418|ref|YP_001822137.1| epoxide hydrolase 632772015238 Epoxide hydrolase N terminus; Region: EHN; pfam06441 632772015239 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 632772015240 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 632772015241 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 632772015242 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632772015243 active site 632772015244 phosphorylation site [posttranslational modification] 632772015245 intermolecular recognition site; other site 632772015246 dimerization interface [polypeptide binding]; other site 632772015247 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 632772015248 DNA binding site [nucleotide binding] 632772015249 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 632772015250 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 632772015251 dimerization interface [polypeptide binding]; other site 632772015252 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 632772015253 dimer interface [polypeptide binding]; other site 632772015254 phosphorylation site [posttranslational modification] 632772015255 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632772015256 ATP binding site [chemical binding]; other site 632772015257 Mg2+ binding site [ion binding]; other site 632772015258 G-X-G motif; other site 632772015259 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 632772015260 nucleotide binding site/active site [active] 632772015261 HIT family signature motif; other site 632772015262 catalytic residue [active] 632772015263 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 632772015264 Ligand binding site; other site 632772015265 Ligand binding site; other site 632772015266 Ligand binding site; other site 632772015267 Putative Catalytic site; other site 632772015268 DXD motif; other site 632772015269 Predicted membrane protein [Function unknown]; Region: COG2246 632772015270 GtrA-like protein; Region: GtrA; pfam04138 632772015271 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 632772015272 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 632772015273 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 632772015274 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 632772015275 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 632772015276 active site 632772015277 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 632772015278 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772015279 substrate binding site [chemical binding]; other site 632772015280 oxyanion hole (OAH) forming residues; other site 632772015281 trimer interface [polypeptide binding]; other site 632772015282 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 632772015283 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 632772015284 DUF35 OB-fold domain; Region: DUF35; pfam01796 632772015285 lipid-transfer protein; Provisional; Region: PRK08256 632772015286 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 632772015287 active site 632772015288 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772015289 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772015290 active site 632772015291 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 632772015292 Phosphotransferase enzyme family; Region: APH; pfam01636 632772015293 putative active site [active] 632772015294 putative substrate binding site [chemical binding]; other site 632772015295 ATP binding site [chemical binding]; other site 632772015296 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772015297 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772015298 active site 632772015299 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 632772015300 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772015301 NAD(P) binding site [chemical binding]; other site 632772015302 active site 632772015303 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 632772015304 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772015305 NAD(P) binding site [chemical binding]; other site 632772015306 active site 632772015307 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 632772015308 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 632772015309 NAD(P) binding site [chemical binding]; other site 632772015310 AMP-binding enzyme; Region: AMP-binding; pfam00501 632772015311 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772015312 acyl-activating enzyme (AAE) consensus motif; other site 632772015313 AMP binding site [chemical binding]; other site 632772015314 active site 632772015315 CoA binding site [chemical binding]; other site 632772015316 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772015317 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772015318 EthD domain; Region: EthD; cl17553 632772015319 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 632772015320 Prostaglandin dehydrogenases; Region: PGDH; cd05288 632772015321 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 632772015322 NAD(P) binding site [chemical binding]; other site 632772015323 substrate binding site [chemical binding]; other site 632772015324 dimer interface [polypeptide binding]; other site 632772015325 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772015326 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 632772015327 NAD(P) binding site [chemical binding]; other site 632772015328 active site 632772015329 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 632772015330 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772015331 dimer interface [polypeptide binding]; other site 632772015332 conserved gate region; other site 632772015333 ABC-ATPase subunit interface; other site 632772015334 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772015335 dimer interface [polypeptide binding]; other site 632772015336 conserved gate region; other site 632772015337 putative PBP binding loops; other site 632772015338 ABC-ATPase subunit interface; other site 632772015339 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 632772015340 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632772015341 Walker A/P-loop; other site 632772015342 ATP binding site [chemical binding]; other site 632772015343 Q-loop/lid; other site 632772015344 ABC transporter signature motif; other site 632772015345 Walker B; other site 632772015346 D-loop; other site 632772015347 H-loop/switch region; other site 632772015348 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772015349 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 632772015350 NAD(P) binding site [chemical binding]; other site 632772015351 active site 632772015352 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 632772015353 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 632772015354 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 632772015355 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 632772015356 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 632772015357 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 632772015358 phosphate binding site [ion binding]; other site 632772015359 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 632772015360 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 632772015361 TM-ABC transporter signature motif; other site 632772015362 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 632772015363 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 632772015364 TM-ABC transporter signature motif; other site 632772015365 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 632772015366 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 632772015367 Walker A/P-loop; other site 632772015368 ATP binding site [chemical binding]; other site 632772015369 Q-loop/lid; other site 632772015370 ABC transporter signature motif; other site 632772015371 Walker B; other site 632772015372 D-loop; other site 632772015373 H-loop/switch region; other site 632772015374 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 632772015375 Walker A/P-loop; other site 632772015376 ATP binding site [chemical binding]; other site 632772015377 Q-loop/lid; other site 632772015378 ABC transporter signature motif; other site 632772015379 Walker B; other site 632772015380 D-loop; other site 632772015381 H-loop/switch region; other site 632772015382 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 632772015383 classical (c) SDRs; Region: SDR_c; cd05233 632772015384 NAD(P) binding site [chemical binding]; other site 632772015385 active site 632772015386 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 632772015387 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 632772015388 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 632772015389 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 632772015390 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 632772015391 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 632772015392 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 632772015393 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 632772015394 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772015395 NAD(P) binding site [chemical binding]; other site 632772015396 active site 632772015397 metabolite-proton symporter; Region: 2A0106; TIGR00883 632772015398 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772015399 putative substrate translocation pore; other site 632772015400 Transcriptional regulator [Transcription]; Region: LysR; COG0583 632772015401 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 632772015402 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 632772015403 dimerization interface [polypeptide binding]; other site 632772015404 aspartate aminotransferase; Provisional; Region: PRK05764 632772015405 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 632772015406 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632772015407 homodimer interface [polypeptide binding]; other site 632772015408 catalytic residue [active] 632772015409 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 632772015410 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 632772015411 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 632772015412 Protein of unknown function (DUF998); Region: DUF998; pfam06197 632772015413 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 632772015414 TAP-like protein; Region: Abhydrolase_4; pfam08386 632772015415 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 632772015416 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 632772015417 Lyase; Region: Lyase_1; pfam00206 632772015418 tetramer interface [polypeptide binding]; other site 632772015419 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 632772015420 HIT family signature motif; other site 632772015421 catalytic residue [active] 632772015422 NRDE protein; Region: NRDE; cl01315 632772015423 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 632772015424 MarR family; Region: MarR; pfam01047 632772015425 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 632772015426 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632772015427 Walker A/P-loop; other site 632772015428 ATP binding site [chemical binding]; other site 632772015429 Q-loop/lid; other site 632772015430 ABC transporter signature motif; other site 632772015431 Walker B; other site 632772015432 D-loop; other site 632772015433 H-loop/switch region; other site 632772015434 ABC-2 type transporter; Region: ABC2_membrane; cl17235 632772015435 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 632772015436 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 632772015437 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 632772015438 acyl-activating enzyme (AAE) consensus motif; other site 632772015439 active site 632772015440 AMP binding site [chemical binding]; other site 632772015441 substrate binding site [chemical binding]; other site 632772015442 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772015443 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316 632772015444 NAD(P) binding site [chemical binding]; other site 632772015445 active site 632772015446 isochorismate synthase DhbC; Validated; Region: PRK06923 632772015447 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 632772015448 Condensation domain; Region: Condensation; pfam00668 632772015449 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772015450 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 632772015451 acyl-activating enzyme (AAE) consensus motif; other site 632772015452 AMP binding site [chemical binding]; other site 632772015453 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772015454 Condensation domain; Region: Condensation; pfam00668 632772015455 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 632772015456 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772015457 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772015458 acyl-activating enzyme (AAE) consensus motif; other site 632772015459 AMP binding site [chemical binding]; other site 632772015460 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772015461 Condensation domain; Region: Condensation; pfam00668 632772015462 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 632772015463 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 632772015464 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 632772015465 intersubunit interface [polypeptide binding]; other site 632772015466 Condensation domain; Region: Condensation; pfam00668 632772015467 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 632772015468 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772015469 acyl-activating enzyme (AAE) consensus motif; other site 632772015470 AMP binding site [chemical binding]; other site 632772015471 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772015472 Condensation domain; Region: Condensation; pfam00668 632772015473 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 632772015474 Condensation domain; Region: Condensation; pfam00668 632772015475 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 632772015476 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772015477 acyl-activating enzyme (AAE) consensus motif; other site 632772015478 AMP binding site [chemical binding]; other site 632772015479 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772015480 Condensation domain; Region: Condensation; pfam00668 632772015481 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 632772015482 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 632772015483 enterobactin exporter EntS; Provisional; Region: PRK10489 632772015484 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772015485 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 632772015486 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 632772015487 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 632772015488 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 632772015489 dimerization interface [polypeptide binding]; other site 632772015490 putative DNA binding site [nucleotide binding]; other site 632772015491 putative Zn2+ binding site [ion binding]; other site 632772015492 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 632772015493 Na binding site [ion binding]; other site 632772015494 amidase; Provisional; Region: PRK07486 632772015495 Amidase; Region: Amidase; cl11426 632772015496 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 632772015497 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 632772015498 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 632772015499 tartrate dehydrogenase; Region: TTC; TIGR02089 632772015500 Transcriptional regulator [Transcription]; Region: LysR; COG0583 632772015501 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 632772015502 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 632772015503 dimerization interface [polypeptide binding]; other site 632772015504 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 632772015505 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 632772015506 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 632772015507 glycerate dehydrogenase; Provisional; Region: PRK06932 632772015508 NAD binding site [chemical binding]; other site 632772015509 ligand binding site [chemical binding]; other site 632772015510 catalytic site [active] 632772015511 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772015512 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632772015513 putative substrate translocation pore; other site 632772015514 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 632772015515 ATP binding site [chemical binding]; other site 632772015516 active site 632772015517 substrate binding site [chemical binding]; other site 632772015518 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 632772015519 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 632772015520 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 632772015521 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632772015522 active site 632772015523 phosphorylation site [posttranslational modification] 632772015524 intermolecular recognition site; other site 632772015525 dimerization interface [polypeptide binding]; other site 632772015526 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 632772015527 putative Zn2+ binding site [ion binding]; other site 632772015528 putative DNA binding site [nucleotide binding]; other site 632772015529 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 632772015530 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632772015531 ATP binding site [chemical binding]; other site 632772015532 Mg2+ binding site [ion binding]; other site 632772015533 G-X-G motif; other site 632772015534 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 632772015535 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 632772015536 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 632772015537 catalytic residues [active] 632772015538 dimer interface [polypeptide binding]; other site 632772015539 Predicted deacetylase [General function prediction only]; Region: COG3233 632772015540 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 632772015541 putative active site [active] 632772015542 putative Zn binding site [ion binding]; other site 632772015543 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 632772015544 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 632772015545 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 632772015546 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 632772015547 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 632772015548 putative active site [active] 632772015549 catalytic triad [active] 632772015550 putative methyltransferase; Provisional; Region: PRK14967 632772015551 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 632772015552 S-adenosylmethionine binding site [chemical binding]; other site 632772015553 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 632772015554 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 632772015555 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772015556 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772015557 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 632772015558 glycosyltransferase, MGT family; Region: MGT; TIGR01426 632772015559 active site 632772015560 TDP-binding site; other site 632772015561 acceptor substrate-binding pocket; other site 632772015562 homodimer interface [polypeptide binding]; other site 632772015563 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 632772015564 active site 632772015565 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 632772015566 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 632772015567 active site 632772015568 metal binding site [ion binding]; metal-binding site 632772015569 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 632772015570 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 632772015571 dimerization interface [polypeptide binding]; other site 632772015572 ATP binding site [chemical binding]; other site 632772015573 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 632772015574 dimerization interface [polypeptide binding]; other site 632772015575 ATP binding site [chemical binding]; other site 632772015576 Predicted membrane protein [Function unknown]; Region: COG4425 632772015577 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 632772015578 CAAX protease self-immunity; Region: Abi; pfam02517 632772015579 amidophosphoribosyltransferase; Provisional; Region: PRK07847 632772015580 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 632772015581 active site 632772015582 tetramer interface [polypeptide binding]; other site 632772015583 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 632772015584 active site 632772015585 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 632772015586 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 632772015587 dimerization interface [polypeptide binding]; other site 632772015588 putative ATP binding site [chemical binding]; other site 632772015589 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 632772015590 L-asparaginase II; Region: Asparaginase_II; pfam06089 632772015591 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 632772015592 MOSC domain; Region: MOSC; pfam03473 632772015593 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 632772015594 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 632772015595 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 632772015596 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 632772015597 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 632772015598 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632772015599 catalytic residue [active] 632772015600 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 632772015601 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 632772015602 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 632772015603 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 632772015604 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 632772015605 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632772015606 Walker A/P-loop; other site 632772015607 ATP binding site [chemical binding]; other site 632772015608 Q-loop/lid; other site 632772015609 ABC transporter signature motif; other site 632772015610 Walker B; other site 632772015611 D-loop; other site 632772015612 H-loop/switch region; other site 632772015613 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 632772015614 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632772015615 Walker A/P-loop; other site 632772015616 ATP binding site [chemical binding]; other site 632772015617 Q-loop/lid; other site 632772015618 ABC transporter signature motif; other site 632772015619 Walker B; other site 632772015620 D-loop; other site 632772015621 H-loop/switch region; other site 632772015622 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 632772015623 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 632772015624 heme-binding site [chemical binding]; other site 632772015625 Cutinase; Region: Cutinase; pfam01083 632772015626 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 632772015627 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 632772015628 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 632772015629 active site residue [active] 632772015630 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 632772015631 active site residue [active] 632772015632 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 632772015633 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 632772015634 catalytic residues [active] 632772015635 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 632772015636 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 632772015637 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 632772015638 DNA binding site [nucleotide binding] 632772015639 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 632772015640 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 632772015641 Coenzyme A binding pocket [chemical binding]; other site 632772015642 PBP superfamily domain; Region: PBP_like_2; cl17296 632772015643 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 632772015644 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772015645 dimer interface [polypeptide binding]; other site 632772015646 conserved gate region; other site 632772015647 putative PBP binding loops; other site 632772015648 ABC-ATPase subunit interface; other site 632772015649 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 632772015650 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772015651 dimer interface [polypeptide binding]; other site 632772015652 conserved gate region; other site 632772015653 putative PBP binding loops; other site 632772015654 ABC-ATPase subunit interface; other site 632772015655 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 632772015656 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 632772015657 Walker A/P-loop; other site 632772015658 ATP binding site [chemical binding]; other site 632772015659 Q-loop/lid; other site 632772015660 ABC transporter signature motif; other site 632772015661 Walker B; other site 632772015662 D-loop; other site 632772015663 H-loop/switch region; other site 632772015664 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 632772015665 PhoU domain; Region: PhoU; pfam01895 632772015666 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 632772015667 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 632772015668 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 632772015669 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 632772015670 FMN binding site [chemical binding]; other site 632772015671 active site 632772015672 catalytic residues [active] 632772015673 substrate binding site [chemical binding]; other site 632772015674 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 632772015675 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 632772015676 homodimer interface [polypeptide binding]; other site 632772015677 putative substrate binding pocket [chemical binding]; other site 632772015678 diiron center [ion binding]; other site 632772015679 Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078 632772015680 Protein of unknown function (DUF419); Region: DUF419; pfam04237 632772015681 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 632772015682 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 632772015683 catalytic Zn binding site [ion binding]; other site 632772015684 NAD binding site [chemical binding]; other site 632772015685 structural Zn binding site [ion binding]; other site 632772015686 GXWXG protein; Region: GXWXG; pfam14231 632772015687 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 632772015688 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772015689 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772015690 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 632772015691 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632772015692 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 632772015693 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772015694 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772015695 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772015696 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772015697 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 632772015698 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 632772015699 Walker A/P-loop; other site 632772015700 ATP binding site [chemical binding]; other site 632772015701 Q-loop/lid; other site 632772015702 ABC transporter signature motif; other site 632772015703 Walker B; other site 632772015704 D-loop; other site 632772015705 H-loop/switch region; other site 632772015706 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 632772015707 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 632772015708 TM-ABC transporter signature motif; other site 632772015709 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 632772015710 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 632772015711 Walker A/P-loop; other site 632772015712 ATP binding site [chemical binding]; other site 632772015713 Q-loop/lid; other site 632772015714 ABC transporter signature motif; other site 632772015715 Walker B; other site 632772015716 D-loop; other site 632772015717 H-loop/switch region; other site 632772015718 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 632772015719 TM-ABC transporter signature motif; other site 632772015720 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 632772015721 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 632772015722 ligand binding site [chemical binding]; other site 632772015723 classical (c) SDRs; Region: SDR_c; cd05233 632772015724 NAD(P) binding site [chemical binding]; other site 632772015725 active site 632772015726 Predicted integral membrane protein [Function unknown]; Region: COG0392 632772015727 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772015728 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 632772015729 NAD(P) binding site [chemical binding]; other site 632772015730 active site 632772015731 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 632772015732 Ligand Binding Site [chemical binding]; other site 632772015733 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 632772015734 Ligand Binding Site [chemical binding]; other site 632772015735 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 632772015736 putative active site; other site 632772015737 putative metal binding residues [ion binding]; other site 632772015738 signature motif; other site 632772015739 putative triphosphate binding site [ion binding]; other site 632772015740 CHAD domain; Region: CHAD; pfam05235 632772015741 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 632772015742 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 632772015743 probable active site [active] 632772015744 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 632772015745 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 632772015746 short chain dehydrogenase; Provisional; Region: PRK06197 632772015747 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 632772015748 putative NAD(P) binding site [chemical binding]; other site 632772015749 active site 632772015750 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 632772015751 Transcriptional regulators [Transcription]; Region: MarR; COG1846 632772015752 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 632772015753 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642 632772015754 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772015755 NAD(P) binding site [chemical binding]; other site 632772015756 active site 632772015757 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 632772015758 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 632772015759 active site 632772015760 non-prolyl cis peptide bond; other site 632772015761 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 632772015762 Citrate transporter; Region: CitMHS; pfam03600 632772015763 Lsr2; Region: Lsr2; pfam11774 632772015764 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 632772015765 NlpC/P60 family; Region: NLPC_P60; cl17555 632772015766 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 632772015767 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 632772015768 phosphopeptide binding site; other site 632772015769 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 632772015770 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 632772015771 phosphopeptide binding site; other site 632772015772 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 632772015773 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 632772015774 Walker A/P-loop; other site 632772015775 ATP binding site [chemical binding]; other site 632772015776 Q-loop/lid; other site 632772015777 ABC transporter signature motif; other site 632772015778 Walker B; other site 632772015779 D-loop; other site 632772015780 H-loop/switch region; other site 632772015781 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 632772015782 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 632772015783 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 632772015784 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 632772015785 hypothetical protein; Provisional; Region: PRK06184 632772015786 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 632772015787 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 632772015788 Catalytic domain of Protein Kinases; Region: PKc; cd00180 632772015789 active site 632772015790 ATP binding site [chemical binding]; other site 632772015791 substrate binding site [chemical binding]; other site 632772015792 activation loop (A-loop); other site 632772015793 Predicted ATPase [General function prediction only]; Region: COG3903 632772015794 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632772015795 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632772015796 DNA binding residues [nucleotide binding] 632772015797 dimerization interface [polypeptide binding]; other site 632772015798 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 632772015799 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 632772015800 amidohydrolase; Region: amidohydrolases; TIGR01891 632772015801 metal binding site [ion binding]; metal-binding site 632772015802 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772015803 putative substrate translocation pore; other site 632772015804 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 632772015805 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 632772015806 AsnC family; Region: AsnC_trans_reg; pfam01037 632772015807 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 632772015808 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 632772015809 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 632772015810 Clp amino terminal domain; Region: Clp_N; pfam02861 632772015811 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632772015812 Walker A motif; other site 632772015813 ATP binding site [chemical binding]; other site 632772015814 Walker B motif; other site 632772015815 arginine finger; other site 632772015816 UvrB/uvrC motif; Region: UVR; pfam02151 632772015817 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632772015818 Walker A motif; other site 632772015819 ATP binding site [chemical binding]; other site 632772015820 Walker B motif; other site 632772015821 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 632772015822 putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208 632772015823 oligomer interface [polypeptide binding]; other site 632772015824 Transcriptional regulator [Transcription]; Region: IclR; COG1414 632772015825 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 632772015826 Bacterial transcriptional regulator; Region: IclR; pfam01614 632772015827 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 632772015828 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 632772015829 dimerization interface [polypeptide binding]; other site 632772015830 ligand binding site [chemical binding]; other site 632772015831 NADP binding site [chemical binding]; other site 632772015832 catalytic site [active] 632772015833 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 632772015834 active site 632772015835 catalytic residues [active] 632772015836 metal binding site [ion binding]; metal-binding site 632772015837 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 632772015838 CoA-transferase family III; Region: CoA_transf_3; pfam02515 632772015839 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 632772015840 fructuronate transporter; Provisional; Region: PRK10034; cl15264 632772015841 fructuronate transporter; Provisional; Region: PRK10034; cl15264 632772015842 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 632772015843 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 632772015844 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 632772015845 MMPL family; Region: MMPL; pfam03176 632772015846 MMPL family; Region: MMPL; pfam03176 632772015847 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 632772015848 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 632772015849 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 632772015850 6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase, N-benzyl-3-pyrrolidinol dehydrogenase, and other MDR family members; Region: hydroxyacyl_CoA_DH; cd08254 632772015851 putative NAD(P) binding site [chemical binding]; other site 632772015852 catalytic Zn binding site [ion binding]; other site 632772015853 structural Zn binding site [ion binding]; other site 632772015854 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 632772015855 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 632772015856 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 632772015857 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632772015858 aminotransferase; Validated; Region: PRK07777 632772015859 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 632772015860 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632772015861 homodimer interface [polypeptide binding]; other site 632772015862 catalytic residue [active] 632772015863 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 632772015864 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 632772015865 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 632772015866 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632772015867 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 632772015868 NMT1/THI5 like; Region: NMT1; pfam09084 632772015869 NMT1-like family; Region: NMT1_2; pfam13379 632772015870 membrane-bound complex binding site; other site 632772015871 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 632772015872 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 632772015873 substrate binding pocket [chemical binding]; other site 632772015874 membrane-bound complex binding site; other site 632772015875 hinge residues; other site 632772015876 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 632772015877 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 632772015878 Walker A/P-loop; other site 632772015879 ATP binding site [chemical binding]; other site 632772015880 Q-loop/lid; other site 632772015881 ABC transporter signature motif; other site 632772015882 Walker B; other site 632772015883 D-loop; other site 632772015884 H-loop/switch region; other site 632772015885 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 632772015886 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772015887 dimer interface [polypeptide binding]; other site 632772015888 conserved gate region; other site 632772015889 putative PBP binding loops; other site 632772015890 ABC-ATPase subunit interface; other site 632772015891 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 632772015892 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 632772015893 active site 632772015894 non-prolyl cis peptide bond; other site 632772015895 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772015896 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632772015897 putative substrate translocation pore; other site 632772015898 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 632772015899 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 632772015900 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 632772015901 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 632772015902 Protein of unknown function (DUF3239); Region: DUF3239; pfam11580 632772015903 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 632772015904 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 632772015905 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 632772015906 putative Mg++ binding site [ion binding]; other site 632772015907 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 632772015908 nucleotide binding region [chemical binding]; other site 632772015909 ATP-binding site [chemical binding]; other site 632772015910 MarR family; Region: MarR_2; cl17246 632772015911 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 632772015912 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 632772015913 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 632772015914 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 632772015915 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 632772015916 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772015917 putative PBP binding loops; other site 632772015918 dimer interface [polypeptide binding]; other site 632772015919 ABC-ATPase subunit interface; other site 632772015920 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 632772015921 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 632772015922 Walker A/P-loop; other site 632772015923 ATP binding site [chemical binding]; other site 632772015924 Q-loop/lid; other site 632772015925 ABC transporter signature motif; other site 632772015926 Walker B; other site 632772015927 D-loop; other site 632772015928 H-loop/switch region; other site 632772015929 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 632772015930 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 632772015931 active site 632772015932 non-prolyl cis peptide bond; other site 632772015933 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 632772015934 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 632772015935 Putative esterase; Region: Esterase; pfam00756 632772015936 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 632772015937 WYL domain; Region: WYL; pfam13280 632772015938 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 632772015939 hypothetical protein; Provisional; Region: PRK11770 632772015940 Domain of unknown function (DUF307); Region: DUF307; pfam03733 632772015941 Domain of unknown function (DUF307); Region: DUF307; pfam03733 632772015942 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 632772015943 DNA-binding site [nucleotide binding]; DNA binding site 632772015944 RNA-binding motif; other site 632772015945 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 632772015946 H+ Antiporter protein; Region: 2A0121; TIGR00900 632772015947 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 632772015948 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 632772015949 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 632772015950 active site 632772015951 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 632772015952 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 632772015953 MarR family; Region: MarR_2; cl17246 632772015954 H+ Antiporter protein; Region: 2A0121; TIGR00900 632772015955 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772015956 putative substrate translocation pore; other site 632772015957 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632772015958 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 632772015959 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 632772015960 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 632772015961 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 632772015962 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 632772015963 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 632772015964 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 632772015965 catalytic loop [active] 632772015966 iron binding site [ion binding]; other site 632772015967 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 632772015968 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 632772015969 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 632772015970 metal ion-dependent adhesion site (MIDAS); other site 632772015971 MoxR-like ATPases [General function prediction only]; Region: COG0714 632772015972 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632772015973 Walker A motif; other site 632772015974 ATP binding site [chemical binding]; other site 632772015975 Walker B motif; other site 632772015976 arginine finger; other site 632772015977 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 632772015978 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772015979 NAD(P) binding site [chemical binding]; other site 632772015980 active site 632772015981 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 632772015982 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 632772015983 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 632772015984 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 632772015985 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 632772015986 nucleoside/Zn binding site; other site 632772015987 dimer interface [polypeptide binding]; other site 632772015988 catalytic motif [active] 632772015989 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 632772015990 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 632772015991 catalytic residue [active] 632772015992 citrate synthase 2; Provisional; Region: PRK12350 632772015993 Citrate synthase; Region: Citrate_synt; pfam00285 632772015994 oxalacetate binding site [chemical binding]; other site 632772015995 citrylCoA binding site [chemical binding]; other site 632772015996 coenzyme A binding site [chemical binding]; other site 632772015997 catalytic triad [active] 632772015998 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 632772015999 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 632772016000 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 632772016001 enterobactin exporter EntS; Provisional; Region: PRK10489 632772016002 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772016003 putative substrate translocation pore; other site 632772016004 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 632772016005 active site 632772016006 catalytic residues [active] 632772016007 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 632772016008 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 632772016009 dimer interface [polypeptide binding]; other site 632772016010 active site 632772016011 citrylCoA binding site [chemical binding]; other site 632772016012 NADH binding [chemical binding]; other site 632772016013 cationic pore residues; other site 632772016014 oxalacetate/citrate binding site [chemical binding]; other site 632772016015 coenzyme A binding site [chemical binding]; other site 632772016016 catalytic triad [active] 632772016017 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 632772016018 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 632772016019 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 632772016020 phosphorylation site [posttranslational modification] 632772016021 dimer interface [polypeptide binding]; other site 632772016022 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632772016023 ATP binding site [chemical binding]; other site 632772016024 Mg2+ binding site [ion binding]; other site 632772016025 G-X-G motif; other site 632772016026 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 632772016027 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632772016028 active site 632772016029 phosphorylation site [posttranslational modification] 632772016030 intermolecular recognition site; other site 632772016031 dimerization interface [polypeptide binding]; other site 632772016032 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 632772016033 DNA binding site [nucleotide binding] 632772016034 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 632772016035 Mechanosensitive ion channel; Region: MS_channel; pfam00924 632772016036 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 632772016037 DNA photolyase; Region: DNA_photolyase; pfam00875 632772016038 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772016039 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632772016040 putative substrate translocation pore; other site 632772016041 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772016042 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772016043 CobD/Cbib protein; Region: CobD_Cbib; cl00561 632772016044 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 632772016045 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 632772016046 acyl-activating enzyme (AAE) consensus motif; other site 632772016047 putative AMP binding site [chemical binding]; other site 632772016048 putative active site [active] 632772016049 putative CoA binding site [chemical binding]; other site 632772016050 Putative esterase; Region: Esterase; pfam00756 632772016051 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 632772016052 Domain of unknown function (DUF222); Region: DUF222; pfam02720 632772016053 Domain of unknown function (DUF222); Region: DUF222; pfam02720 632772016054 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 632772016055 active site 632772016056 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 632772016057 dimer interface [polypeptide binding]; other site 632772016058 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 632772016059 Ligand Binding Site [chemical binding]; other site 632772016060 Molecular Tunnel; other site 632772016061 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 632772016062 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 632772016063 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 632772016064 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 632772016065 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 632772016066 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 632772016067 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 632772016068 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 632772016069 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 632772016070 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 632772016071 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 632772016072 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 632772016073 hydrophobic ligand binding site; other site 632772016074 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 632772016075 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 632772016076 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 632772016077 Probable transposase; Region: OrfB_IS605; pfam01385 632772016078 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 632772016079 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 632772016080 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 632772016081 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 632772016082 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632772016083 Walker A/P-loop; other site 632772016084 ATP binding site [chemical binding]; other site 632772016085 Q-loop/lid; other site 632772016086 ABC transporter signature motif; other site 632772016087 Walker B; other site 632772016088 D-loop; other site 632772016089 H-loop/switch region; other site 632772016090 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 632772016091 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 632772016092 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 632772016093 non-specific DNA binding site [nucleotide binding]; other site 632772016094 salt bridge; other site 632772016095 sequence-specific DNA binding site [nucleotide binding]; other site 632772016096 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 632772016097 Ferredoxin [Energy production and conversion]; Region: COG1146 632772016098 4Fe-4S binding domain; Region: Fer4; pfam00037 632772016099 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 632772016100 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632772016101 Walker A/P-loop; other site 632772016102 ATP binding site [chemical binding]; other site 632772016103 Q-loop/lid; other site 632772016104 ABC transporter signature motif; other site 632772016105 Walker B; other site 632772016106 D-loop; other site 632772016107 H-loop/switch region; other site 632772016108 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 632772016109 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772016110 Methyltransferase domain; Region: Methyltransf_31; pfam13847 632772016111 S-adenosylmethionine binding site [chemical binding]; other site 632772016112 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 632772016113 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 632772016114 active site 632772016115 catalytic tetrad [active] 632772016116 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 632772016117 MMPL family; Region: MMPL; pfam03176 632772016118 MMPL family; Region: MMPL; pfam03176 632772016119 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 632772016120 Bacterial transcriptional activator domain; Region: BTAD; smart01043 632772016121 AAA ATPase domain; Region: AAA_16; pfam13191 632772016122 Hemerythrin-like domain; Region: Hr-like; cd12108 632772016123 Fe binding site [ion binding]; other site 632772016124 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 632772016125 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 632772016126 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 632772016127 putative active site [active] 632772016128 putative active site [active] 632772016129 catalytic site [active] 632772016130 catalytic site [active] 632772016131 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 632772016132 putative active site [active] 632772016133 catalytic site [active] 632772016134 Secretory lipase; Region: LIP; pfam03583 632772016135 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 632772016136 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 632772016137 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 632772016138 enoyl-CoA hydratase; Provisional; Region: PRK06688 632772016139 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772016140 substrate binding site [chemical binding]; other site 632772016141 oxyanion hole (OAH) forming residues; other site 632772016142 trimer interface [polypeptide binding]; other site 632772016143 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 632772016144 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 632772016145 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 632772016146 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 632772016147 Soluble P-type ATPase [General function prediction only]; Region: COG4087 632772016148 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 632772016149 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 632772016150 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 632772016151 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 632772016152 Secretory lipase; Region: LIP; pfam03583 632772016153 Protein of unknown function (DUF419); Region: DUF419; pfam04237 632772016154 Histidine kinase; Region: His_kinase; pfam06580 632772016155 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632772016156 ATP binding site [chemical binding]; other site 632772016157 Mg2+ binding site [ion binding]; other site 632772016158 G-X-G motif; other site 632772016159 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 632772016160 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632772016161 active site 632772016162 phosphorylation site [posttranslational modification] 632772016163 intermolecular recognition site; other site 632772016164 dimerization interface [polypeptide binding]; other site 632772016165 LytTr DNA-binding domain; Region: LytTR; smart00850 632772016166 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 632772016167 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 632772016168 Na binding site [ion binding]; other site 632772016169 Protein of unknown function, DUF485; Region: DUF485; pfam04341 632772016170 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 632772016171 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 632772016172 Na binding site [ion binding]; other site 632772016173 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 632772016174 hydrophobic ligand binding site; other site 632772016175 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 632772016176 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 632772016177 substrate binding pocket [chemical binding]; other site 632772016178 membrane-bound complex binding site; other site 632772016179 hinge residues; other site 632772016180 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 632772016181 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 632772016182 nucleotide binding site [chemical binding]; other site 632772016183 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 632772016184 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 632772016185 active site 632772016186 DNA binding site [nucleotide binding] 632772016187 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 632772016188 DNA binding site [nucleotide binding] 632772016189 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 632772016190 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632772016191 active site 632772016192 phosphorylation site [posttranslational modification] 632772016193 intermolecular recognition site; other site 632772016194 dimerization interface [polypeptide binding]; other site 632772016195 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 632772016196 DNA binding site [nucleotide binding] 632772016197 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 632772016198 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 632772016199 dimerization interface [polypeptide binding]; other site 632772016200 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 632772016201 dimer interface [polypeptide binding]; other site 632772016202 phosphorylation site [posttranslational modification] 632772016203 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632772016204 ATP binding site [chemical binding]; other site 632772016205 Mg2+ binding site [ion binding]; other site 632772016206 G-X-G motif; other site 632772016207 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 632772016208 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 632772016209 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632772016210 Walker A/P-loop; other site 632772016211 ATP binding site [chemical binding]; other site 632772016212 Q-loop/lid; other site 632772016213 ABC transporter signature motif; other site 632772016214 Walker B; other site 632772016215 D-loop; other site 632772016216 H-loop/switch region; other site 632772016217 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 632772016218 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772016219 DNA-binding site [nucleotide binding]; DNA binding site 632772016220 FCD domain; Region: FCD; pfam07729 632772016221 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 632772016222 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 632772016223 CoA-transferase family III; Region: CoA_transf_3; pfam02515 632772016224 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772016225 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772016226 active site 632772016227 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772016228 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772016229 active site 632772016230 short chain dehydrogenase; Provisional; Region: PRK07791 632772016231 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772016232 NAD(P) binding site [chemical binding]; other site 632772016233 active site 632772016234 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 632772016235 active site 632772016236 catalytic site [active] 632772016237 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 632772016238 active site 2 [active] 632772016239 active site 1 [active] 632772016240 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 632772016241 hydrophobic ligand binding site; other site 632772016242 lipid-transfer protein; Provisional; Region: PRK08256 632772016243 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 632772016244 active site 632772016245 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772016246 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772016247 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 632772016248 Catalytic domain of Protein Kinases; Region: PKc; cd00180 632772016249 active site 632772016250 ATP binding site [chemical binding]; other site 632772016251 substrate binding site [chemical binding]; other site 632772016252 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 632772016253 substrate binding site [chemical binding]; other site 632772016254 activation loop (A-loop); other site 632772016255 activation loop (A-loop); other site 632772016256 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 632772016257 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 632772016258 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772016259 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772016260 active site 632772016261 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 632772016262 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 632772016263 homodimer interface [polypeptide binding]; other site 632772016264 substrate-cofactor binding pocket; other site 632772016265 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632772016266 catalytic residue [active] 632772016267 OsmC-like protein; Region: OsmC; pfam02566 632772016268 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 632772016269 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772016270 DNA-binding site [nucleotide binding]; DNA binding site 632772016271 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 632772016272 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632772016273 homodimer interface [polypeptide binding]; other site 632772016274 catalytic residue [active] 632772016275 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 632772016276 Uncharacterized conserved protein [Function unknown]; Region: COG2128 632772016277 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 632772016278 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 632772016279 dimer interface [polypeptide binding]; other site 632772016280 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 632772016281 active site 632772016282 Fe binding site [ion binding]; other site 632772016283 Transcriptional regulator [Transcription]; Region: IclR; COG1414 632772016284 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632772016285 dimerization interface [polypeptide binding]; other site 632772016286 putative Zn2+ binding site [ion binding]; other site 632772016287 putative DNA binding site [nucleotide binding]; other site 632772016288 Bacterial transcriptional regulator; Region: IclR; pfam01614 632772016289 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 632772016290 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 632772016291 trimer interface [polypeptide binding]; other site 632772016292 putative metal binding site [ion binding]; other site 632772016293 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 632772016294 CoA-transferase family III; Region: CoA_transf_3; pfam02515 632772016295 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 632772016296 active site 632772016297 catalytic residues [active] 632772016298 metal binding site [ion binding]; metal-binding site 632772016299 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 632772016300 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 632772016301 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 632772016302 Sulfate transporter family; Region: Sulfate_transp; pfam00916 632772016303 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 632772016304 active site clefts [active] 632772016305 zinc binding site [ion binding]; other site 632772016306 dimer interface [polypeptide binding]; other site 632772016307 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 632772016308 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772016309 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772016310 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 632772016311 cyclase homology domain; Region: CHD; cd07302 632772016312 nucleotidyl binding site; other site 632772016313 metal binding site [ion binding]; metal-binding site 632772016314 dimer interface [polypeptide binding]; other site 632772016315 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 632772016316 6-phosphogluconate dehydratase; Region: edd; TIGR01196 632772016317 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 632772016318 TIGR03086 family protein; Region: TIGR03086 632772016319 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 632772016320 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 632772016321 active site 632772016322 catalytic tetrad [active] 632772016323 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772016324 putative substrate translocation pore; other site 632772016325 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632772016326 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 632772016327 FAD binding domain; Region: FAD_binding_4; pfam01565 632772016328 diacylglycerol kinase; Reviewed; Region: PRK11914 632772016329 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 632772016330 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 632772016331 RNA binding surface [nucleotide binding]; other site 632772016332 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772016333 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 632772016334 putative substrate translocation pore; other site 632772016335 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772016336 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632772016337 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772016338 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 632772016339 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772016340 S-adenosylmethionine binding site [chemical binding]; other site 632772016341 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 632772016342 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 632772016343 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 632772016344 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772016345 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 632772016346 FAD binding site [chemical binding]; other site 632772016347 homotetramer interface [polypeptide binding]; other site 632772016348 substrate binding pocket [chemical binding]; other site 632772016349 catalytic base [active] 632772016350 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772016351 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772016352 Condensation domain; Region: Condensation; pfam00668 632772016353 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 632772016354 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772016355 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772016356 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 632772016357 acyl-activating enzyme (AAE) consensus motif; other site 632772016358 AMP binding site [chemical binding]; other site 632772016359 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772016360 Condensation domain; Region: Condensation; pfam00668 632772016361 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 632772016362 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772016363 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772016364 acyl-activating enzyme (AAE) consensus motif; other site 632772016365 AMP binding site [chemical binding]; other site 632772016366 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772016367 peptide synthase; Provisional; Region: PRK12316 632772016368 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772016369 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772016370 acyl-activating enzyme (AAE) consensus motif; other site 632772016371 AMP binding site [chemical binding]; other site 632772016372 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772016373 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 632772016374 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772016375 acyl-activating enzyme (AAE) consensus motif; other site 632772016376 AMP binding site [chemical binding]; other site 632772016377 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772016378 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772016379 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772016380 acyl-activating enzyme (AAE) consensus motif; other site 632772016381 AMP binding site [chemical binding]; other site 632772016382 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772016383 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 632772016384 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772016385 acyl-activating enzyme (AAE) consensus motif; other site 632772016386 AMP binding site [chemical binding]; other site 632772016387 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772016388 Condensation domain; Region: Condensation; pfam00668 632772016389 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 632772016390 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772016391 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772016392 acyl-activating enzyme (AAE) consensus motif; other site 632772016393 AMP binding site [chemical binding]; other site 632772016394 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772016395 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 632772016396 Condensation domain; Region: Condensation; pfam00668 632772016397 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 632772016398 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772016399 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772016400 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 632772016401 acyl-activating enzyme (AAE) consensus motif; other site 632772016402 AMP binding site [chemical binding]; other site 632772016403 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772016404 Condensation domain; Region: Condensation; pfam00668 632772016405 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 632772016406 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772016407 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772016408 acyl-activating enzyme (AAE) consensus motif; other site 632772016409 AMP binding site [chemical binding]; other site 632772016410 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772016411 peptide synthase; Provisional; Region: PRK12316 632772016412 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772016413 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772016414 acyl-activating enzyme (AAE) consensus motif; other site 632772016415 AMP binding site [chemical binding]; other site 632772016416 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772016417 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 632772016418 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772016419 acyl-activating enzyme (AAE) consensus motif; other site 632772016420 AMP binding site [chemical binding]; other site 632772016421 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772016422 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772016423 acyl-activating enzyme (AAE) consensus motif; other site 632772016424 AMP binding site [chemical binding]; other site 632772016425 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772016426 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 632772016427 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772016428 acyl-activating enzyme (AAE) consensus motif; other site 632772016429 AMP binding site [chemical binding]; other site 632772016430 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772016431 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 632772016432 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772016433 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772016434 acyl-activating enzyme (AAE) consensus motif; other site 632772016435 AMP binding site [chemical binding]; other site 632772016436 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772016437 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 632772016438 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 632772016439 active site 632772016440 catalytic site [active] 632772016441 substrate binding site [chemical binding]; other site 632772016442 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 632772016443 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 632772016444 oligomer interface [polypeptide binding]; other site 632772016445 metal binding site [ion binding]; metal-binding site 632772016446 metal binding site [ion binding]; metal-binding site 632772016447 putative Cl binding site [ion binding]; other site 632772016448 basic sphincter; other site 632772016449 hydrophobic gate; other site 632772016450 periplasmic entrance; other site 632772016451 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 632772016452 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 632772016453 active site 632772016454 DNA binding site [nucleotide binding] 632772016455 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 632772016456 DNA binding site [nucleotide binding] 632772016457 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 632772016458 nucleotide binding site [chemical binding]; other site 632772016459 potential frameshift: common BLAST hit: gi|111022870|ref|YP_705842.1| beta-lactamase precursor 632772016460 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 632772016461 Beta-lactamase; Region: Beta-lactamase; pfam00144 632772016462 Beta-lactamase; Region: Beta-lactamase; cl17358 632772016463 Dodecin; Region: Dodecin; pfam07311 632772016464 Ferredoxin [Energy production and conversion]; Region: COG1146 632772016465 4Fe-4S binding domain; Region: Fer4; pfam00037 632772016466 ferredoxin-NADP+ reductase; Region: PLN02852 632772016467 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 632772016468 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 632772016469 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 632772016470 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 632772016471 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 632772016472 Walker A/P-loop; other site 632772016473 ATP binding site [chemical binding]; other site 632772016474 Q-loop/lid; other site 632772016475 ABC transporter signature motif; other site 632772016476 Walker B; other site 632772016477 D-loop; other site 632772016478 H-loop/switch region; other site 632772016479 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 632772016480 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 632772016481 active site 632772016482 Zn binding site [ion binding]; other site 632772016483 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 632772016484 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 632772016485 active site 632772016486 Pirin; Region: Pirin; pfam02678 632772016487 Pirin-related protein [General function prediction only]; Region: COG1741 632772016488 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 632772016489 putative active site [active] 632772016490 putative catalytic site [active] 632772016491 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 632772016492 active site 632772016493 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 632772016494 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772016495 NAD(P) binding site [chemical binding]; other site 632772016496 active site 632772016497 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 632772016498 MarR family; Region: MarR; pfam01047 632772016499 Protein of unknown function (DUF3237); Region: DUF3237; pfam11578 632772016500 Transcriptional regulator [Transcription]; Region: LysR; COG0583 632772016501 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 632772016502 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 632772016503 dimerization interface [polypeptide binding]; other site 632772016504 substrate binding pocket [chemical binding]; other site 632772016505 shikimate transporter; Provisional; Region: PRK09952 632772016506 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772016507 putative substrate translocation pore; other site 632772016508 Predicted acyl esterases [General function prediction only]; Region: COG2936 632772016509 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 632772016510 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 632772016511 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 632772016512 conserved cys residue [active] 632772016513 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 632772016514 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 632772016515 acyl-activating enzyme (AAE) consensus motif; other site 632772016516 putative AMP binding site [chemical binding]; other site 632772016517 putative active site [active] 632772016518 putative CoA binding site [chemical binding]; other site 632772016519 metabolite-proton symporter; Region: 2A0106; TIGR00883 632772016520 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772016521 putative substrate translocation pore; other site 632772016522 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772016523 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772016524 active site 632772016525 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 632772016526 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 632772016527 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 632772016528 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 632772016529 active site 632772016530 Putative esterase; Region: Esterase; pfam00756 632772016531 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 632772016532 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 632772016533 substrate binding pocket [chemical binding]; other site 632772016534 membrane-bound complex binding site; other site 632772016535 hinge residues; other site 632772016536 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 632772016537 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772016538 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772016539 active site 632772016540 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 632772016541 putative dimer interface [polypeptide binding]; other site 632772016542 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 632772016543 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 632772016544 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 632772016545 nucleoside/Zn binding site; other site 632772016546 dimer interface [polypeptide binding]; other site 632772016547 catalytic motif [active] 632772016548 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 632772016549 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632772016550 Walker A/P-loop; other site 632772016551 ATP binding site [chemical binding]; other site 632772016552 ABC transporter signature motif; other site 632772016553 Walker B; other site 632772016554 D-loop; other site 632772016555 H-loop/switch region; other site 632772016556 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 632772016557 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 632772016558 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 632772016559 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 632772016560 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 632772016561 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772016562 putative substrate translocation pore; other site 632772016563 POT family; Region: PTR2; cl17359 632772016564 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 632772016565 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772016566 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772016567 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 632772016568 2-isopropylmalate synthase; Validated; Region: PRK03739 632772016569 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 632772016570 active site 632772016571 catalytic residues [active] 632772016572 metal binding site [ion binding]; metal-binding site 632772016573 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 632772016574 Transcriptional regulators [Transcription]; Region: FadR; COG2186 632772016575 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772016576 DNA-binding site [nucleotide binding]; DNA binding site 632772016577 Predicted integral membrane protein [Function unknown]; Region: COG0392 632772016578 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 632772016579 dimerization interface [polypeptide binding]; other site 632772016580 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 632772016581 cyclase homology domain; Region: CHD; cd07302 632772016582 nucleotidyl binding site; other site 632772016583 metal binding site [ion binding]; metal-binding site 632772016584 dimer interface [polypeptide binding]; other site 632772016585 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 632772016586 Domain of unknown function DUF20; Region: UPF0118; pfam01594 632772016587 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632772016588 ATP binding site [chemical binding]; other site 632772016589 Mg2+ binding site [ion binding]; other site 632772016590 G-X-G motif; other site 632772016591 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632772016592 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632772016593 active site 632772016594 phosphorylation site [posttranslational modification] 632772016595 intermolecular recognition site; other site 632772016596 dimerization interface [polypeptide binding]; other site 632772016597 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632772016598 DNA binding residues [nucleotide binding] 632772016599 dimerization interface [polypeptide binding]; other site 632772016600 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 632772016601 MMPL family; Region: MMPL; pfam03176 632772016602 MMPL family; Region: MMPL; pfam03176 632772016603 LabA_like proteins; Region: LabA_like; cd06167 632772016604 putative metal binding site [ion binding]; other site 632772016605 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 632772016606 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 632772016607 Switch II region; other site 632772016608 G4 box; other site 632772016609 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 632772016610 active site 632772016611 substrate-binding site [chemical binding]; other site 632772016612 metal-binding site [ion binding] 632772016613 GTP binding site [chemical binding]; other site 632772016614 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 632772016615 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 632772016616 NAD binding site [chemical binding]; other site 632772016617 catalytic residues [active] 632772016618 Phosphotransferase enzyme family; Region: APH; pfam01636 632772016619 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 632772016620 putative active site [active] 632772016621 putative substrate binding site [chemical binding]; other site 632772016622 ATP binding site [chemical binding]; other site 632772016623 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 632772016624 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 632772016625 Methyltransferase domain; Region: Methyltransf_11; pfam08241 632772016626 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 632772016627 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 632772016628 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 632772016629 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 632772016630 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 632772016631 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 632772016632 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 632772016633 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 632772016634 Ligand Binding Site [chemical binding]; other site 632772016635 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 632772016636 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 632772016637 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772016638 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772016639 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 632772016640 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 632772016641 active site 2 [active] 632772016642 active site 1 [active] 632772016643 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 632772016644 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772016645 NAD(P) binding site [chemical binding]; other site 632772016646 active site 632772016647 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 632772016648 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 632772016649 dimer interface [polypeptide binding]; other site 632772016650 active site 632772016651 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 632772016652 VanW like protein; Region: VanW; pfam04294 632772016653 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 632772016654 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 632772016655 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 632772016656 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 632772016657 FAD binding site [chemical binding]; other site 632772016658 substrate binding site [chemical binding]; other site 632772016659 catalytic residues [active] 632772016660 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 632772016661 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772016662 S-adenosylmethionine binding site [chemical binding]; other site 632772016663 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 632772016664 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 632772016665 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 632772016666 dimer interface [polypeptide binding]; other site 632772016667 active site 632772016668 CoA binding pocket [chemical binding]; other site 632772016669 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 632772016670 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 632772016671 Uncharacterized conserved protein [Function unknown]; Region: COG3379 632772016672 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 632772016673 Cytochrome P450; Region: p450; cl12078 632772016674 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 632772016675 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 632772016676 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 632772016677 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 632772016678 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 632772016679 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 632772016680 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 632772016681 putative active site [active] 632772016682 putative substrate binding site [chemical binding]; other site 632772016683 putative FMN binding site [chemical binding]; other site 632772016684 putative catalytic residues [active] 632772016685 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 632772016686 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632772016687 DNA binding residues [nucleotide binding] 632772016688 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 632772016689 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 632772016690 Putative esterase; Region: Esterase; pfam00756 632772016691 hypothetical protein; Provisional; Region: PRK09256 632772016692 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 632772016693 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 632772016694 DNA binding residues [nucleotide binding] 632772016695 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 632772016696 active site 632772016697 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 632772016698 putative hydrophobic ligand binding site [chemical binding]; other site 632772016699 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632772016700 dimerization interface [polypeptide binding]; other site 632772016701 putative DNA binding site [nucleotide binding]; other site 632772016702 putative Zn2+ binding site [ion binding]; other site 632772016703 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772016704 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772016705 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 632772016706 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 632772016707 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 632772016708 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 632772016709 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 632772016710 XdhC Rossmann domain; Region: XdhC_C; pfam13478 632772016711 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 632772016712 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 632772016713 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 632772016714 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 632772016715 catalytic loop [active] 632772016716 iron binding site [ion binding]; other site 632772016717 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 632772016718 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 632772016719 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 632772016720 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 632772016721 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 632772016722 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 632772016723 XdhC Rossmann domain; Region: XdhC_C; pfam13478 632772016724 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 632772016725 zinc binding site [ion binding]; other site 632772016726 L3 interface [polypeptide binding]; other site 632772016727 L14 interface [polypeptide binding]; other site 632772016728 23S rRNA interface [nucleotide binding]; other site 632772016729 MoxR-like ATPases [General function prediction only]; Region: COG0714 632772016730 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 632772016731 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 632772016732 putative hydrophobic ligand binding site [chemical binding]; other site 632772016733 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 632772016734 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 632772016735 metal ion-dependent adhesion site (MIDAS); other site 632772016736 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 632772016737 MOSC domain; Region: MOSC; pfam03473 632772016738 3-alpha domain; Region: 3-alpha; pfam03475 632772016739 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 632772016740 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 632772016741 FAD binding pocket [chemical binding]; other site 632772016742 FAD binding motif [chemical binding]; other site 632772016743 phosphate binding motif [ion binding]; other site 632772016744 beta-alpha-beta structure motif; other site 632772016745 NAD binding pocket [chemical binding]; other site 632772016746 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 632772016747 catalytic loop [active] 632772016748 iron binding site [ion binding]; other site 632772016749 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 632772016750 nucleotide binding site [chemical binding]; other site 632772016751 PAS domain; Region: PAS_9; pfam13426 632772016752 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 632772016753 putative active site [active] 632772016754 heme pocket [chemical binding]; other site 632772016755 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 632772016756 Catalytic domain of Protein Kinases; Region: PKc; cd00180 632772016757 active site 632772016758 ATP binding site [chemical binding]; other site 632772016759 substrate binding site [chemical binding]; other site 632772016760 activation loop (A-loop); other site 632772016761 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 632772016762 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 632772016763 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 632772016764 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 632772016765 Transcriptional regulators [Transcription]; Region: GntR; COG1802 632772016766 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772016767 DNA-binding site [nucleotide binding]; DNA binding site 632772016768 FCD domain; Region: FCD; pfam07729 632772016769 Transcriptional regulators [Transcription]; Region: PurR; COG1609 632772016770 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 632772016771 DNA binding site [nucleotide binding] 632772016772 domain linker motif; other site 632772016773 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 632772016774 ligand binding site [chemical binding]; other site 632772016775 dimerization interface [polypeptide binding]; other site 632772016776 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 632772016777 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 632772016778 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 632772016779 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 632772016780 Transcriptional regulator [Transcription]; Region: LysR; COG0583 632772016781 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 632772016782 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 632772016783 dimerization interface [polypeptide binding]; other site 632772016784 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 632772016785 EamA-like transporter family; Region: EamA; pfam00892 632772016786 BioY family; Region: BioY; pfam02632 632772016787 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772016788 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772016789 AMP binding site [chemical binding]; other site 632772016790 active site 632772016791 acyl-activating enzyme (AAE) consensus motif; other site 632772016792 acyl-activating enzyme (AAE) consensus motif; other site 632772016793 CoA binding site [chemical binding]; other site 632772016794 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 632772016795 active site 632772016796 EamA-like transporter family; Region: EamA; pfam00892 632772016797 BioY family; Region: BioY; pfam02632 632772016798 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772016799 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772016800 AMP binding site [chemical binding]; other site 632772016801 active site 632772016802 acyl-activating enzyme (AAE) consensus motif; other site 632772016803 acyl-activating enzyme (AAE) consensus motif; other site 632772016804 CoA binding site [chemical binding]; other site 632772016805 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 632772016806 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 632772016807 dimer interface [polypeptide binding]; other site 632772016808 active site 632772016809 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 632772016810 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 632772016811 Walker A/P-loop; other site 632772016812 ATP binding site [chemical binding]; other site 632772016813 Q-loop/lid; other site 632772016814 ABC transporter signature motif; other site 632772016815 Walker B; other site 632772016816 D-loop; other site 632772016817 H-loop/switch region; other site 632772016818 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 632772016819 acyl-CoA synthetase; Validated; Region: PRK07638 632772016820 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772016821 AMP binding site [chemical binding]; other site 632772016822 active site 632772016823 acyl-activating enzyme (AAE) consensus motif; other site 632772016824 CoA binding site [chemical binding]; other site 632772016825 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 632772016826 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 632772016827 Citrate transporter; Region: CitMHS; pfam03600 632772016828 Transcriptional regulator [Transcription]; Region: LysR; COG0583 632772016829 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 632772016830 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 632772016831 putative dimerization interface [polypeptide binding]; other site 632772016832 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 632772016833 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 632772016834 Transcriptional regulators [Transcription]; Region: PurR; COG1609 632772016835 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 632772016836 DNA binding site [nucleotide binding] 632772016837 domain linker motif; other site 632772016838 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 632772016839 ligand binding site [chemical binding]; other site 632772016840 dimerization interface [polypeptide binding]; other site 632772016841 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 632772016842 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 632772016843 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 632772016844 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 632772016845 Histidine kinase; Region: HisKA_3; pfam07730 632772016846 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632772016847 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632772016848 active site 632772016849 phosphorylation site [posttranslational modification] 632772016850 intermolecular recognition site; other site 632772016851 dimerization interface [polypeptide binding]; other site 632772016852 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632772016853 DNA binding residues [nucleotide binding] 632772016854 dimerization interface [polypeptide binding]; other site 632772016855 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 632772016856 metal binding site 2 [ion binding]; metal-binding site 632772016857 putative DNA binding helix; other site 632772016858 metal binding site 1 [ion binding]; metal-binding site 632772016859 dimer interface [polypeptide binding]; other site 632772016860 structural Zn2+ binding site [ion binding]; other site 632772016861 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 632772016862 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 632772016863 dimer interface [polypeptide binding]; other site 632772016864 active site 632772016865 heme binding site [chemical binding]; other site 632772016866 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 632772016867 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772016868 acetoin reductases; Region: 23BDH; TIGR02415 632772016869 NAD(P) binding site [chemical binding]; other site 632772016870 active site 632772016871 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 632772016872 PrpF protein; Region: PrpF; pfam04303 632772016873 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 632772016874 Transcriptional regulator [Transcription]; Region: LysR; COG0583 632772016875 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 632772016876 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 632772016877 putative dimerization interface [polypeptide binding]; other site 632772016878 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 632772016879 CoA-transferase family III; Region: CoA_transf_3; pfam02515 632772016880 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 632772016881 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 632772016882 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772016883 putative substrate translocation pore; other site 632772016884 Transcriptional regulator [Transcription]; Region: LysR; COG0583 632772016885 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 632772016886 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 632772016887 putative dimerization interface [polypeptide binding]; other site 632772016888 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 632772016889 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 632772016890 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 632772016891 NAD(P) binding site [chemical binding]; other site 632772016892 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 632772016893 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 632772016894 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 632772016895 AsnC family; Region: AsnC_trans_reg; pfam01037 632772016896 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 632772016897 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 632772016898 substrate binding site [chemical binding]; other site 632772016899 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 632772016900 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 632772016901 substrate binding site [chemical binding]; other site 632772016902 ligand binding site [chemical binding]; other site 632772016903 2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386 632772016904 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 632772016905 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 632772016906 transmembrane helices; other site 632772016907 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 632772016908 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 632772016909 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 632772016910 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 632772016911 active site 632772016912 SnoaL-like domain; Region: SnoaL_4; pfam13577 632772016913 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 632772016914 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 632772016915 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 632772016916 dimerization interface [polypeptide binding]; other site 632772016917 substrate binding pocket [chemical binding]; other site 632772016918 SnoaL-like domain; Region: SnoaL_2; pfam12680 632772016919 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 632772016920 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 632772016921 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 632772016922 catalytic site [active] 632772016923 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772016924 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772016925 active site 632772016926 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 632772016927 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 632772016928 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 632772016929 active site 632772016930 metal binding site [ion binding]; metal-binding site 632772016931 Helix-turn-helix domain; Region: HTH_18; pfam12833 632772016932 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632772016933 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 632772016934 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 632772016935 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 632772016936 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 632772016937 active site 632772016938 metal binding site [ion binding]; metal-binding site 632772016939 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 632772016940 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 632772016941 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 632772016942 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 632772016943 Transcriptional regulators [Transcription]; Region: FadR; COG2186 632772016944 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772016945 DNA-binding site [nucleotide binding]; DNA binding site 632772016946 FCD domain; Region: FCD; pfam07729 632772016947 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 632772016948 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 632772016949 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772016950 short chain dehydrogenase; Provisional; Region: PRK06701 632772016951 NAD(P) binding site [chemical binding]; other site 632772016952 active site 632772016953 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 632772016954 iron-sulfur cluster [ion binding]; other site 632772016955 [2Fe-2S] cluster binding site [ion binding]; other site 632772016956 potential frameshift: common BLAST hit: gi|134100687|ref|YP_001106348.1| NAD-dependent epimerase/dehydratase 632772016957 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772016958 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772016959 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 632772016960 NAD(P) binding site [chemical binding]; other site 632772016961 active site 632772016962 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 632772016963 Transposase; Region: DDE_Tnp_ISL3; pfam01610 632772016964 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 632772016965 Transposase; Region: DDE_Tnp_ISL3; pfam01610 632772016966 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 632772016967 active site 632772016968 Transcriptional regulators [Transcription]; Region: GntR; COG1802 632772016969 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772016970 DNA-binding site [nucleotide binding]; DNA binding site 632772016971 FCD domain; Region: FCD; pfam07729 632772016972 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 632772016973 MarR family; Region: MarR_2; pfam12802 632772016974 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 632772016975 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 632772016976 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 632772016977 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 632772016978 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 632772016979 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 632772016980 catalytic loop [active] 632772016981 iron binding site [ion binding]; other site 632772016982 conserved hypothetical protein; Region: TIGR02118 632772016983 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 632772016984 Cytochrome P450; Region: p450; cl12078 632772016985 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 632772016986 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632772016987 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 632772016988 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 632772016989 catalytic loop [active] 632772016990 iron binding site [ion binding]; other site 632772016991 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 632772016992 FAD binding pocket [chemical binding]; other site 632772016993 conserved FAD binding motif [chemical binding]; other site 632772016994 phosphate binding motif [ion binding]; other site 632772016995 beta-alpha-beta structure motif; other site 632772016996 NAD binding pocket [chemical binding]; other site 632772016997 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 632772016998 Cytochrome P450; Region: p450; cl12078 632772016999 N-terminal, non-catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_N_like; cd09013 632772017000 tetramer interface [polypeptide binding]; other site 632772017001 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 632772017002 C-terminal, catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_C_like; cd09014 632772017003 tetramer interface [polypeptide binding]; other site 632772017004 active site 632772017005 metal binding site [ion binding]; metal-binding site 632772017006 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 632772017007 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 632772017008 putative molybdopterin cofactor binding site [chemical binding]; other site 632772017009 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 632772017010 putative molybdopterin cofactor binding site; other site 632772017011 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 632772017012 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 632772017013 putative acyltransferase; Provisional; Region: PRK05790 632772017014 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 632772017015 dimer interface [polypeptide binding]; other site 632772017016 active site 632772017017 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 632772017018 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 632772017019 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 632772017020 SCP-2 sterol transfer family; Region: SCP2; cl01225 632772017021 SCP-2 sterol transfer family; Region: SCP2; cl01225 632772017022 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 632772017023 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 632772017024 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 632772017025 hexamer interface [polypeptide binding]; other site 632772017026 active site 2 [active] 632772017027 short chain dehydrogenase; Provisional; Region: PRK12829 632772017028 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772017029 NAD(P) binding site [chemical binding]; other site 632772017030 active site 632772017031 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 632772017032 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 632772017033 NAD binding site [chemical binding]; other site 632772017034 catalytic residues [active] 632772017035 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 632772017036 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 632772017037 active site 632772017038 catalytic residues [active] 632772017039 metal binding site [ion binding]; metal-binding site 632772017040 DmpG-like communication domain; Region: DmpG_comm; pfam07836 632772017041 acetaldehyde dehydrogenase; Validated; Region: PRK08300 632772017042 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 632772017043 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 632772017044 N-terminal, non-catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_N_like; cd09013 632772017045 tetramer interface [polypeptide binding]; other site 632772017046 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 632772017047 C-terminal, catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_C_like; cd09014 632772017048 tetramer interface [polypeptide binding]; other site 632772017049 active site 632772017050 metal binding site [ion binding]; metal-binding site 632772017051 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 632772017052 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 632772017053 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 632772017054 Cytochrome P450; Region: p450; cl12078 632772017055 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 632772017056 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 632772017057 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 632772017058 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 632772017059 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 632772017060 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632772017061 putative transposase OrfB; Reviewed; Region: PHA02517 632772017062 HTH-like domain; Region: HTH_21; pfam13276 632772017063 Integrase core domain; Region: rve; pfam00665 632772017064 Integrase core domain; Region: rve_3; pfam13683 632772017065 Transposase; Region: HTH_Tnp_1; cl17663 632772017066 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772017067 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772017068 active site 632772017069 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 632772017070 active site 1 [active] 632772017071 dimer interface [polypeptide binding]; other site 632772017072 hexamer interface [polypeptide binding]; other site 632772017073 active site 2 [active] 632772017074 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 632772017075 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 632772017076 Transcriptional regulator [Transcription]; Region: IclR; COG1414 632772017077 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 632772017078 Bacterial transcriptional regulator; Region: IclR; pfam01614 632772017079 Transcriptional regulator [Transcription]; Region: IclR; COG1414 632772017080 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 632772017081 Bacterial transcriptional regulator; Region: IclR; pfam01614 632772017082 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 632772017083 Catalytic domain of Protein Kinases; Region: PKc; cd00180 632772017084 active site 632772017085 ATP binding site [chemical binding]; other site 632772017086 substrate binding site [chemical binding]; other site 632772017087 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 632772017088 substrate binding site [chemical binding]; other site 632772017089 activation loop (A-loop); other site 632772017090 activation loop (A-loop); other site 632772017091 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 632772017092 AAA ATPase domain; Region: AAA_16; pfam13191 632772017093 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 632772017094 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 632772017095 G1 box; other site 632772017096 GTP/Mg2+ binding site [chemical binding]; other site 632772017097 G2 box; other site 632772017098 Switch I region; other site 632772017099 G3 box; other site 632772017100 Switch II region; other site 632772017101 G4 box; other site 632772017102 G5 box; other site 632772017103 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 632772017104 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 632772017105 Ubiquitin-like proteins; Region: UBQ; cl00155 632772017106 charged pocket; other site 632772017107 hydrophobic patch; other site 632772017108 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632772017109 ATP binding site [chemical binding]; other site 632772017110 Mg2+ binding site [ion binding]; other site 632772017111 G-X-G motif; other site 632772017112 Helix-turn-helix domain; Region: HTH_17; pfam12728 632772017113 PIN domain; Region: PIN_3; pfam13470 632772017114 AAA domain; Region: AAA_25; pfam13481 632772017115 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 632772017116 Walker A motif; other site 632772017117 ATP binding site [chemical binding]; other site 632772017118 Walker B motif; other site 632772017119 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 632772017120 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 632772017121 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 632772017122 active site 632772017123 DNA binding site [nucleotide binding] 632772017124 Int/Topo IB signature motif; other site 632772017125 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 632772017126 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772017127 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 632772017128 trimer interface [polypeptide binding]; other site 632772017129 active site 632772017130 PGAP1-like protein; Region: PGAP1; pfam07819 632772017131 CHAT domain; Region: CHAT; cl17868 632772017132 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 632772017133 active site 632772017134 catalytic residues [active] 632772017135 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 632772017136 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 632772017137 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 632772017138 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 632772017139 active site 632772017140 substrate binding site [chemical binding]; other site 632772017141 Mg2+ binding site [ion binding]; other site 632772017142 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275 632772017143 active site 632772017144 Rogdi leucine zipper containing protein; Region: Rogdi_lz; pfam10259 632772017145 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 632772017146 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 632772017147 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 632772017148 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 632772017149 Walker A/P-loop; other site 632772017150 ATP binding site [chemical binding]; other site 632772017151 Q-loop/lid; other site 632772017152 ABC transporter signature motif; other site 632772017153 Walker B; other site 632772017154 D-loop; other site 632772017155 H-loop/switch region; other site 632772017156 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 632772017157 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 632772017158 Walker A/P-loop; other site 632772017159 ATP binding site [chemical binding]; other site 632772017160 Q-loop/lid; other site 632772017161 ABC transporter signature motif; other site 632772017162 Walker B; other site 632772017163 D-loop; other site 632772017164 H-loop/switch region; other site 632772017165 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 632772017166 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 632772017167 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772017168 dimer interface [polypeptide binding]; other site 632772017169 conserved gate region; other site 632772017170 putative PBP binding loops; other site 632772017171 ABC-ATPase subunit interface; other site 632772017172 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 632772017173 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772017174 putative PBP binding loops; other site 632772017175 dimer interface [polypeptide binding]; other site 632772017176 ABC-ATPase subunit interface; other site 632772017177 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 632772017178 Rdx family; Region: Rdx; cl01407 632772017179 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 632772017180 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 632772017181 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 632772017182 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 632772017183 RNA polymerase factor sigma-70; Validated; Region: PRK08241 632772017184 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632772017185 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 632772017186 DNA binding residues [nucleotide binding] 632772017187 SnoaL-like domain; Region: SnoaL_4; pfam13577 632772017188 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 632772017189 putative hydrophobic ligand binding site [chemical binding]; other site 632772017190 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632772017191 dimerization interface [polypeptide binding]; other site 632772017192 putative DNA binding site [nucleotide binding]; other site 632772017193 putative Zn2+ binding site [ion binding]; other site 632772017194 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 632772017195 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632772017196 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772017197 putative substrate translocation pore; other site 632772017198 Transcriptional regulators [Transcription]; Region: MarR; COG1846 632772017199 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632772017200 dimerization interface [polypeptide binding]; other site 632772017201 putative Zn2+ binding site [ion binding]; other site 632772017202 putative DNA binding site [nucleotide binding]; other site 632772017203 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632772017204 dimerization interface [polypeptide binding]; other site 632772017205 putative DNA binding site [nucleotide binding]; other site 632772017206 putative Zn2+ binding site [ion binding]; other site 632772017207 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 632772017208 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 632772017209 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 632772017210 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 632772017211 active site residue [active] 632772017212 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 632772017213 active site residue [active] 632772017214 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 632772017215 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 632772017216 CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427 632772017217 DXD motif; other site 632772017218 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 632772017219 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 632772017220 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 632772017221 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 632772017222 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 632772017223 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 632772017224 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632772017225 motif II; other site 632772017226 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 632772017227 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 632772017228 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 632772017229 active site 632772017230 TDP-binding site; other site 632772017231 acceptor substrate-binding pocket; other site 632772017232 homodimer interface [polypeptide binding]; other site 632772017233 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 632772017234 Bacterial sugar transferase; Region: Bac_transf; pfam02397 632772017235 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 632772017236 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 632772017237 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 632772017238 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 632772017239 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 632772017240 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 632772017241 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 632772017242 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 632772017243 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 632772017244 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 632772017245 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 632772017246 Probable Catalytic site; other site 632772017247 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 632772017248 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 632772017249 Condensation domain; Region: Condensation; pfam00668 632772017250 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772017251 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 632772017252 acyl-activating enzyme (AAE) consensus motif; other site 632772017253 AMP binding site [chemical binding]; other site 632772017254 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772017255 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772017256 acyl-activating enzyme (AAE) consensus motif; other site 632772017257 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772017258 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772017259 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772017260 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 632772017261 acyl-activating enzyme (AAE) consensus motif; other site 632772017262 AMP binding site [chemical binding]; other site 632772017263 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772017264 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 632772017265 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772017266 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772017267 acyl-activating enzyme (AAE) consensus motif; other site 632772017268 AMP binding site [chemical binding]; other site 632772017269 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772017270 SPW repeat; Region: SPW; pfam03779 632772017271 SPW repeat; Region: SPW; pfam03779 632772017272 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 632772017273 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 632772017274 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 632772017275 tetrameric interface [polypeptide binding]; other site 632772017276 NAD binding site [chemical binding]; other site 632772017277 catalytic residues [active] 632772017278 substrate binding site [chemical binding]; other site 632772017279 hypothetical protein; Provisional; Region: PRK06541 632772017280 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 632772017281 inhibitor-cofactor binding pocket; inhibition site 632772017282 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632772017283 catalytic residue [active] 632772017284 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 632772017285 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 632772017286 putative DNA binding site [nucleotide binding]; other site 632772017287 putative Zn2+ binding site [ion binding]; other site 632772017288 AsnC family; Region: AsnC_trans_reg; pfam01037 632772017289 Amino acid permease; Region: AA_permease_2; pfam13520 632772017290 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 632772017291 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 632772017292 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 632772017293 Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999 632772017294 putative substrate binding site [chemical binding]; other site 632772017295 active site 632772017296 Domain of unknown function (DUF385); Region: DUF385; pfam04075 632772017297 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865 632772017298 putative hydrophobic ligand binding site [chemical binding]; other site 632772017299 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632772017300 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772017301 putative substrate translocation pore; other site 632772017302 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 632772017303 trimer interface [polypeptide binding]; other site 632772017304 active site 632772017305 substrate binding site [chemical binding]; other site 632772017306 CoA binding site [chemical binding]; other site 632772017307 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 632772017308 Bacterial sugar transferase; Region: Bac_transf; pfam02397 632772017309 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 632772017310 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 632772017311 putative ADP-binding pocket [chemical binding]; other site 632772017312 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 632772017313 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 632772017314 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 632772017315 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 632772017316 Acyltransferase family; Region: Acyl_transf_3; pfam01757 632772017317 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 632772017318 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 632772017319 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 632772017320 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 632772017321 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 632772017322 Uncharacterized conserved protein [Function unknown]; Region: COG1434 632772017323 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 632772017324 putative active site [active] 632772017325 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 632772017326 RNA binding site [nucleotide binding]; other site 632772017327 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 632772017328 DNA-binding site [nucleotide binding]; DNA binding site 632772017329 RNA-binding motif; other site 632772017330 Domain of unknown function (DUF222); Region: DUF222; pfam02720 632772017331 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 632772017332 active site 632772017333 AAA ATPase domain; Region: AAA_16; pfam13191 632772017334 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 632772017335 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632772017336 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632772017337 DNA binding residues [nucleotide binding] 632772017338 dimerization interface [polypeptide binding]; other site 632772017339 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 632772017340 DNA-binding site [nucleotide binding]; DNA binding site 632772017341 RNA-binding motif; other site 632772017342 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 632772017343 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 632772017344 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 632772017345 active site 632772017346 catalytic residues [active] 632772017347 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 632772017348 Condensation domain; Region: Condensation; pfam00668 632772017349 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772017350 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 632772017351 acyl-activating enzyme (AAE) consensus motif; other site 632772017352 AMP binding site [chemical binding]; other site 632772017353 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772017354 Condensation domain; Region: Condensation; pfam00668 632772017355 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 632772017356 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772017357 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772017358 acyl-activating enzyme (AAE) consensus motif; other site 632772017359 AMP binding site [chemical binding]; other site 632772017360 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772017361 Condensation domain; Region: Condensation; pfam00668 632772017362 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 632772017363 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772017364 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772017365 acyl-activating enzyme (AAE) consensus motif; other site 632772017366 AMP binding site [chemical binding]; other site 632772017367 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772017368 Condensation domain; Region: Condensation; pfam00668 632772017369 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 632772017370 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772017371 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772017372 acyl-activating enzyme (AAE) consensus motif; other site 632772017373 AMP binding site [chemical binding]; other site 632772017374 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772017375 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 632772017376 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772017377 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772017378 acyl-activating enzyme (AAE) consensus motif; other site 632772017379 AMP binding site [chemical binding]; other site 632772017380 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772017381 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 632772017382 Chain length determinant protein; Region: Wzz; pfam02706 632772017383 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 632772017384 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 632772017385 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 632772017386 Low molecular weight phosphatase family; Region: LMWPc; cl00105 632772017387 active site 632772017388 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 632772017389 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 632772017390 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 632772017391 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 632772017392 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 632772017393 Lipase (class 2); Region: Lipase_2; pfam01674 632772017394 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 632772017395 YibE/F-like protein; Region: YibE_F; pfam07907 632772017396 Helix-turn-helix domain; Region: HTH_31; pfam13560 632772017397 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 632772017398 aminotransferase AlaT; Validated; Region: PRK09265 632772017399 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 632772017400 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632772017401 homodimer interface [polypeptide binding]; other site 632772017402 catalytic residue [active] 632772017403 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 632772017404 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 632772017405 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 632772017406 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 632772017407 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 632772017408 G1 box; other site 632772017409 GTP/Mg2+ binding site [chemical binding]; other site 632772017410 G2 box; other site 632772017411 Switch I region; other site 632772017412 G3 box; other site 632772017413 Switch II region; other site 632772017414 G4 box; other site 632772017415 G5 box; other site 632772017416 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 632772017417 G1 box; other site 632772017418 GTP/Mg2+ binding site [chemical binding]; other site 632772017419 Switch I region; other site 632772017420 G3 box; other site 632772017421 Switch II region; other site 632772017422 G4 box; other site 632772017423 G5 box; other site 632772017424 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 632772017425 nucleotide binding site [chemical binding]; other site 632772017426 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 632772017427 4Fe-4S binding domain; Region: Fer4; pfam00037 632772017428 Cysteine-rich domain; Region: CCG; pfam02754 632772017429 Cysteine-rich domain; Region: CCG; pfam02754 632772017430 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 632772017431 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 632772017432 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632772017433 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632772017434 DNA binding residues [nucleotide binding] 632772017435 dimerization interface [polypeptide binding]; other site 632772017436 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 632772017437 nucleotide binding site [chemical binding]; other site 632772017438 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 632772017439 G1 box; other site 632772017440 GTP/Mg2+ binding site [chemical binding]; other site 632772017441 G2 box; other site 632772017442 Switch I region; other site 632772017443 G3 box; other site 632772017444 Switch II region; other site 632772017445 G4 box; other site 632772017446 G5 box; other site 632772017447 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 632772017448 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 632772017449 Probable transposase; Region: OrfB_IS605; pfam01385 632772017450 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 632772017451 potential protein location (hypothetical protein) that overlaps protein ( transposase) 632772017452 Transposase IS200 like; Region: Y1_Tnp; pfam01797 632772017453 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 632772017454 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 632772017455 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772017456 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 632772017457 NAD(P) binding site [chemical binding]; other site 632772017458 active site 632772017459 potential frameshift: common BLAST hit: gi|54025750|ref|YP_119992.1| UDP-galactose 4-epimerase 632772017460 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772017461 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 632772017462 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 632772017463 Walker A/P-loop; other site 632772017464 ATP binding site [chemical binding]; other site 632772017465 Q-loop/lid; other site 632772017466 ABC transporter signature motif; other site 632772017467 Walker B; other site 632772017468 D-loop; other site 632772017469 H-loop/switch region; other site 632772017470 TOBE domain; Region: TOBE_2; pfam08402 632772017471 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 632772017472 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 632772017473 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 632772017474 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 632772017475 dimer interface [polypeptide binding]; other site 632772017476 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 632772017477 active site 632772017478 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 632772017479 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772017480 DNA-binding site [nucleotide binding]; DNA binding site 632772017481 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 632772017482 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 632772017483 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 632772017484 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 632772017485 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 632772017486 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 632772017487 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 632772017488 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 632772017489 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772017490 dimer interface [polypeptide binding]; other site 632772017491 conserved gate region; other site 632772017492 putative PBP binding loops; other site 632772017493 ABC-ATPase subunit interface; other site 632772017494 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 632772017495 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772017496 dimer interface [polypeptide binding]; other site 632772017497 conserved gate region; other site 632772017498 putative PBP binding loops; other site 632772017499 ABC-ATPase subunit interface; other site 632772017500 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 632772017501 Melibiase; Region: Melibiase; pfam02065 632772017502 Protein of unknown function (DUF664); Region: DUF664; pfam04978 632772017503 DinB superfamily; Region: DinB_2; pfam12867 632772017504 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 632772017505 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 632772017506 nucleotide binding site [chemical binding]; other site 632772017507 NEF interaction site [polypeptide binding]; other site 632772017508 SBD interface [polypeptide binding]; other site 632772017509 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 632772017510 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 632772017511 dimer interface [polypeptide binding]; other site 632772017512 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 632772017513 chaperone protein DnaJ; Provisional; Region: PRK14281 632772017514 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 632772017515 HSP70 interaction site [polypeptide binding]; other site 632772017516 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 632772017517 Zn binding sites [ion binding]; other site 632772017518 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 632772017519 dimer interface [polypeptide binding]; other site 632772017520 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 632772017521 DNA binding residues [nucleotide binding] 632772017522 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 632772017523 putative dimer interface [polypeptide binding]; other site 632772017524 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632772017525 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632772017526 active site 632772017527 phosphorylation site [posttranslational modification] 632772017528 intermolecular recognition site; other site 632772017529 dimerization interface [polypeptide binding]; other site 632772017530 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632772017531 DNA binding residues [nucleotide binding] 632772017532 dimerization interface [polypeptide binding]; other site 632772017533 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 632772017534 Histidine kinase; Region: HisKA_3; pfam07730 632772017535 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632772017536 ATP binding site [chemical binding]; other site 632772017537 Mg2+ binding site [ion binding]; other site 632772017538 G-X-G motif; other site 632772017539 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 632772017540 intracellular protease, PfpI family; Region: PfpI; TIGR01382 632772017541 proposed catalytic triad [active] 632772017542 conserved cys residue [active] 632772017543 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 632772017544 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 632772017545 NAD binding site [chemical binding]; other site 632772017546 catalytic Zn binding site [ion binding]; other site 632772017547 structural Zn binding site [ion binding]; other site 632772017548 ChaB; Region: ChaB; pfam06150 632772017549 Competence-damaged protein; Region: CinA; pfam02464 632772017550 acyl-CoA synthetase; Validated; Region: PRK06188 632772017551 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772017552 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 632772017553 acyl-activating enzyme (AAE) consensus motif; other site 632772017554 putative AMP binding site [chemical binding]; other site 632772017555 putative active site [active] 632772017556 putative CoA binding site [chemical binding]; other site 632772017557 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 632772017558 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 632772017559 heme-binding site [chemical binding]; other site 632772017560 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 632772017561 FAD binding pocket [chemical binding]; other site 632772017562 FAD binding motif [chemical binding]; other site 632772017563 phosphate binding motif [ion binding]; other site 632772017564 beta-alpha-beta structure motif; other site 632772017565 NAD binding pocket [chemical binding]; other site 632772017566 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 632772017567 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 632772017568 FAD binding pocket [chemical binding]; other site 632772017569 FAD binding motif [chemical binding]; other site 632772017570 phosphate binding motif [ion binding]; other site 632772017571 beta-alpha-beta structure motif; other site 632772017572 NAD binding pocket [chemical binding]; other site 632772017573 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 632772017574 heme-binding site [chemical binding]; other site 632772017575 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 632772017576 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 632772017577 FAD binding pocket [chemical binding]; other site 632772017578 FAD binding motif [chemical binding]; other site 632772017579 phosphate binding motif [ion binding]; other site 632772017580 beta-alpha-beta structure motif; other site 632772017581 NAD binding pocket [chemical binding]; other site 632772017582 Putative esterase; Region: Esterase; pfam00756 632772017583 S-formylglutathione hydrolase; Region: PLN02442 632772017584 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 632772017585 Clp amino terminal domain; Region: Clp_N; pfam02861 632772017586 Clp amino terminal domain; Region: Clp_N; pfam02861 632772017587 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632772017588 Walker A motif; other site 632772017589 ATP binding site [chemical binding]; other site 632772017590 Walker B motif; other site 632772017591 arginine finger; other site 632772017592 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632772017593 Walker A motif; other site 632772017594 ATP binding site [chemical binding]; other site 632772017595 Walker B motif; other site 632772017596 arginine finger; other site 632772017597 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 632772017598 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 632772017599 classical (c) SDRs; Region: SDR_c; cd05233 632772017600 NAD(P) binding site [chemical binding]; other site 632772017601 active site 632772017602 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 632772017603 active site 632772017604 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772017605 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632772017606 putative substrate translocation pore; other site 632772017607 MarR family; Region: MarR_2; cl17246 632772017608 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 632772017609 hydrophobic ligand binding site; other site 632772017610 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 632772017611 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 632772017612 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632772017613 dimerization interface [polypeptide binding]; other site 632772017614 putative DNA binding site [nucleotide binding]; other site 632772017615 putative Zn2+ binding site [ion binding]; other site 632772017616 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 632772017617 putative hydrophobic ligand binding site [chemical binding]; other site 632772017618 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 632772017619 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 632772017620 benzoate transporter; Region: benE; TIGR00843 632772017621 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772017622 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772017623 YhhN-like protein; Region: YhhN; pfam07947 632772017624 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 632772017625 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 632772017626 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 632772017627 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 632772017628 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 632772017629 active site 632772017630 non-prolyl cis peptide bond; other site 632772017631 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 632772017632 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 632772017633 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 632772017634 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 632772017635 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 632772017636 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 632772017637 active site 632772017638 intersubunit interface [polypeptide binding]; other site 632772017639 zinc binding site [ion binding]; other site 632772017640 Na+ binding site [ion binding]; other site 632772017641 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 632772017642 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 632772017643 Predicted membrane protein [Function unknown]; Region: COG4129 632772017644 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 632772017645 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 632772017646 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 632772017647 Predicted transcriptional regulator [Transcription]; Region: COG2378 632772017648 HTH domain; Region: HTH_11; pfam08279 632772017649 WYL domain; Region: WYL; pfam13280 632772017650 Peptidase family M50; Region: Peptidase_M50; pfam02163 632772017651 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 632772017652 active site 632772017653 putative substrate binding region [chemical binding]; other site 632772017654 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 632772017655 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 632772017656 GDP-binding site [chemical binding]; other site 632772017657 ACT binding site; other site 632772017658 IMP binding site; other site 632772017659 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 632772017660 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 632772017661 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 632772017662 DNA binding site [nucleotide binding] 632772017663 active site 632772017664 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 632772017665 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772017666 DNA-binding site [nucleotide binding]; DNA binding site 632772017667 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 632772017668 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632772017669 homodimer interface [polypeptide binding]; other site 632772017670 catalytic residue [active] 632772017671 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 632772017672 CoA-transferase family III; Region: CoA_transf_3; pfam02515 632772017673 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 632772017674 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 632772017675 active site 632772017676 short chain dehydrogenase; Provisional; Region: PRK06197 632772017677 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 632772017678 putative NAD(P) binding site [chemical binding]; other site 632772017679 active site 632772017680 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 632772017681 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 632772017682 substrate binding pocket [chemical binding]; other site 632772017683 catalytic triad [active] 632772017684 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 632772017685 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 632772017686 substrate binding pocket [chemical binding]; other site 632772017687 catalytic triad [active] 632772017688 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 632772017689 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 632772017690 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 632772017691 short chain dehydrogenase; Provisional; Region: PRK08251 632772017692 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772017693 NAD(P) binding site [chemical binding]; other site 632772017694 active site 632772017695 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 632772017696 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 632772017697 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 632772017698 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 632772017699 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 632772017700 active site 632772017701 dimer interface [polypeptide binding]; other site 632772017702 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 632772017703 dimer interface [polypeptide binding]; other site 632772017704 active site 632772017705 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 632772017706 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 632772017707 tetramerization interface [polypeptide binding]; other site 632772017708 NAD(P) binding site [chemical binding]; other site 632772017709 catalytic residues [active] 632772017710 hypothetical protein; Provisional; Region: PRK07857 632772017711 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 632772017712 Part of AAA domain; Region: AAA_19; pfam13245 632772017713 Family description; Region: UvrD_C_2; pfam13538 632772017714 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 632772017715 Peptidase family M23; Region: Peptidase_M23; pfam01551 632772017716 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 632772017717 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 632772017718 CoA-ligase; Region: Ligase_CoA; pfam00549 632772017719 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 632772017720 CoA binding domain; Region: CoA_binding; smart00881 632772017721 CoA-ligase; Region: Ligase_CoA; pfam00549 632772017722 Uncharacterized conserved protein [Function unknown]; Region: COG1739 632772017723 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 632772017724 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 632772017725 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 632772017726 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 632772017727 active site 632772017728 substrate binding site [chemical binding]; other site 632772017729 cosubstrate binding site; other site 632772017730 catalytic site [active] 632772017731 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 632772017732 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 632772017733 purine monophosphate binding site [chemical binding]; other site 632772017734 dimer interface [polypeptide binding]; other site 632772017735 putative catalytic residues [active] 632772017736 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 632772017737 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 632772017738 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 632772017739 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 632772017740 putative active site [active] 632772017741 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 632772017742 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 632772017743 active site 632772017744 metal binding site [ion binding]; metal-binding site 632772017745 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 632772017746 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 632772017747 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 632772017748 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 632772017749 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 632772017750 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 632772017751 metal ion-dependent adhesion site (MIDAS); other site 632772017752 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 632772017753 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 632772017754 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 632772017755 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 632772017756 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 632772017757 active site 632772017758 catalytic triad [active] 632772017759 dimer interface [polypeptide binding]; other site 632772017760 tetracycline repressor protein TetR; Provisional; Region: PRK13756 632772017761 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 632772017762 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 632772017763 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 632772017764 Ligand Binding Site [chemical binding]; other site 632772017765 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 632772017766 Ligand Binding Site [chemical binding]; other site 632772017767 succinic semialdehyde dehydrogenase; Region: PLN02278 632772017768 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 632772017769 tetramerization interface [polypeptide binding]; other site 632772017770 NAD(P) binding site [chemical binding]; other site 632772017771 catalytic residues [active] 632772017772 tyramine oxidase; Provisional; Region: tynA; PRK11504 632772017773 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 632772017774 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 632772017775 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 632772017776 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 632772017777 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 632772017778 inhibitor-cofactor binding pocket; inhibition site 632772017779 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632772017780 catalytic residue [active] 632772017781 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 632772017782 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 632772017783 tetrameric interface [polypeptide binding]; other site 632772017784 NAD binding site [chemical binding]; other site 632772017785 catalytic residues [active] 632772017786 substrate binding site [chemical binding]; other site 632772017787 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 632772017788 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 632772017789 active site 632772017790 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 632772017791 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 632772017792 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 632772017793 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 632772017794 active site 632772017795 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 632772017796 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 632772017797 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 632772017798 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 632772017799 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 632772017800 Predicted permeases [General function prediction only]; Region: COG0679 632772017801 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 632772017802 Beta-lactamase; Region: Beta-lactamase; cl17358 632772017803 Domain of unknown function (DUF305); Region: DUF305; pfam03713 632772017804 30S ribosomal protein S18; Provisional; Region: PRK13401 632772017805 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 632772017806 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 632772017807 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 632772017808 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 632772017809 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 632772017810 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 632772017811 Predicted membrane protein [Function unknown]; Region: COG2860 632772017812 UPF0126 domain; Region: UPF0126; pfam03458 632772017813 UPF0126 domain; Region: UPF0126; pfam03458 632772017814 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 632772017815 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632772017816 active site 632772017817 phosphorylation site [posttranslational modification] 632772017818 intermolecular recognition site; other site 632772017819 dimerization interface [polypeptide binding]; other site 632772017820 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 632772017821 DNA binding site [nucleotide binding] 632772017822 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 632772017823 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 632772017824 dimerization interface [polypeptide binding]; other site 632772017825 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 632772017826 dimer interface [polypeptide binding]; other site 632772017827 phosphorylation site [posttranslational modification] 632772017828 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632772017829 ATP binding site [chemical binding]; other site 632772017830 Mg2+ binding site [ion binding]; other site 632772017831 G-X-G motif; other site 632772017832 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 632772017833 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 632772017834 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 632772017835 MPT binding site; other site 632772017836 trimer interface [polypeptide binding]; other site 632772017837 MspA; Region: MspA; pfam09203 632772017838 MspA; Region: MspA; pfam09203 632772017839 MspA; Region: MspA; pfam09203 632772017840 MspA; Region: MspA; pfam09203 632772017841 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 632772017842 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 632772017843 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 632772017844 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 632772017845 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 632772017846 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 632772017847 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 632772017848 active site 632772017849 tetramer interface; other site 632772017850 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 632772017851 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 632772017852 dimer interface [polypeptide binding]; other site 632772017853 putative functional site; other site 632772017854 putative MPT binding site; other site 632772017855 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 632772017856 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 632772017857 Domain of unknown function (DUF955); Region: DUF955; pfam06114 632772017858 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12854 632772017859 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 632772017860 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 632772017861 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 632772017862 sequence-specific DNA binding site [nucleotide binding]; other site 632772017863 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 632772017864 salt bridge; other site 632772017865 short chain dehydrogenase; Provisional; Region: PRK07832 632772017866 classical (c) SDRs; Region: SDR_c; cd05233 632772017867 NAD(P) binding site [chemical binding]; other site 632772017868 active site 632772017869 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 632772017870 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 632772017871 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632772017872 Walker A/P-loop; other site 632772017873 ATP binding site [chemical binding]; other site 632772017874 Q-loop/lid; other site 632772017875 ABC transporter signature motif; other site 632772017876 Walker B; other site 632772017877 D-loop; other site 632772017878 H-loop/switch region; other site 632772017879 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 632772017880 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 632772017881 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 632772017882 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 632772017883 putative acyl-acceptor binding pocket; other site 632772017884 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 632772017885 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 632772017886 putative acyl-acceptor binding pocket; other site 632772017887 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 632772017888 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 632772017889 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 632772017890 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 632772017891 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 632772017892 DNA binding residues [nucleotide binding] 632772017893 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 632772017894 heme-binding site [chemical binding]; other site 632772017895 arginine deiminase; Provisional; Region: PRK01388 632772017896 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 632772017897 ArsC family; Region: ArsC; pfam03960 632772017898 catalytic residues [active] 632772017899 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772017900 NADH(P)-binding; Region: NAD_binding_10; pfam13460 632772017901 NAD(P) binding site [chemical binding]; other site 632772017902 active site 632772017903 Predicted transcriptional regulators [Transcription]; Region: COG1725 632772017904 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772017905 DNA-binding site [nucleotide binding]; DNA binding site 632772017906 Predicted membrane protein [Function unknown]; Region: COG2259 632772017907 BCCT family transporter; Region: BCCT; pfam02028 632772017908 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 632772017909 Predicted methyltransferases [General function prediction only]; Region: COG0313 632772017910 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 632772017911 putative SAM binding site [chemical binding]; other site 632772017912 putative homodimer interface [polypeptide binding]; other site 632772017913 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 632772017914 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 632772017915 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 632772017916 active site 632772017917 HIGH motif; other site 632772017918 KMSKS motif; other site 632772017919 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 632772017920 tRNA binding surface [nucleotide binding]; other site 632772017921 anticodon binding site; other site 632772017922 short chain dehydrogenase; Provisional; Region: PRK07825 632772017923 classical (c) SDRs; Region: SDR_c; cd05233 632772017924 NAD(P) binding site [chemical binding]; other site 632772017925 active site 632772017926 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 632772017927 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 632772017928 active site 632772017929 Predicted membrane protein [Function unknown]; Region: COG2259 632772017930 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 632772017931 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 632772017932 Walker A/P-loop; other site 632772017933 ATP binding site [chemical binding]; other site 632772017934 Q-loop/lid; other site 632772017935 ABC transporter signature motif; other site 632772017936 Walker B; other site 632772017937 D-loop; other site 632772017938 H-loop/switch region; other site 632772017939 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 632772017940 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 632772017941 substrate binding pocket [chemical binding]; other site 632772017942 membrane-bound complex binding site; other site 632772017943 hinge residues; other site 632772017944 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 632772017945 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772017946 dimer interface [polypeptide binding]; other site 632772017947 conserved gate region; other site 632772017948 putative PBP binding loops; other site 632772017949 ABC-ATPase subunit interface; other site 632772017950 Domain of unknown function (DUF348); Region: DUF348; pfam03990 632772017951 Domain of unknown function (DUF348); Region: DUF348; pfam03990 632772017952 G5 domain; Region: G5; pfam07501 632772017953 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 632772017954 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 632772017955 Domain of unknown function (DUF348); Region: DUF348; pfam03990 632772017956 Domain of unknown function (DUF348); Region: DUF348; pfam03990 632772017957 Domain of unknown function (DUF348); Region: DUF348; pfam03990 632772017958 G5 domain; Region: G5; pfam07501 632772017959 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 632772017960 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 632772017961 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772017962 S-adenosylmethionine binding site [chemical binding]; other site 632772017963 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 632772017964 DNA-binding site [nucleotide binding]; DNA binding site 632772017965 RNA-binding motif; other site 632772017966 HTH domain; Region: HTH_11; pfam08279 632772017967 Predicted transcriptional regulator [Transcription]; Region: COG2378 632772017968 WYL domain; Region: WYL; pfam13280 632772017969 Uncharacterized conserved protein [Function unknown]; Region: COG1434 632772017970 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 632772017971 putative active site [active] 632772017972 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 632772017973 alpha-gamma subunit interface [polypeptide binding]; other site 632772017974 beta-gamma subunit interface [polypeptide binding]; other site 632772017975 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 632772017976 gamma-beta subunit interface [polypeptide binding]; other site 632772017977 alpha-beta subunit interface [polypeptide binding]; other site 632772017978 urease subunit alpha; Reviewed; Region: ureC; PRK13206 632772017979 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 632772017980 subunit interactions [polypeptide binding]; other site 632772017981 active site 632772017982 flap region; other site 632772017983 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 632772017984 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 632772017985 UreD urease accessory protein; Region: UreD; cl00530 632772017986 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 632772017987 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 632772017988 Probable transposase; Region: OrfB_IS605; pfam01385 632772017989 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 632772017990 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 632772017991 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 632772017992 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 632772017993 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 632772017994 ABC transporter; Region: ABC_tran_2; pfam12848 632772017995 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 632772017996 SnoaL-like domain; Region: SnoaL_4; pfam13577 632772017997 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 632772017998 putative dimer interface [polypeptide binding]; other site 632772017999 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 632772018000 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 632772018001 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 632772018002 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 632772018003 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 632772018004 Transcriptional regulator [Transcription]; Region: IclR; COG1414 632772018005 Bacterial transcriptional regulator; Region: IclR; pfam01614 632772018006 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 632772018007 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 632772018008 metal binding site [ion binding]; metal-binding site 632772018009 substrate binding pocket [chemical binding]; other site 632772018010 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 632772018011 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 632772018012 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 632772018013 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772018014 dimer interface [polypeptide binding]; other site 632772018015 conserved gate region; other site 632772018016 putative PBP binding loops; other site 632772018017 ABC-ATPase subunit interface; other site 632772018018 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 632772018019 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 632772018020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772018021 dimer interface [polypeptide binding]; other site 632772018022 ABC-ATPase subunit interface; other site 632772018023 putative PBP binding loops; other site 632772018024 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 632772018025 extended (e) SDRs; Region: SDR_e; cd08946 632772018026 NAD(P) binding site [chemical binding]; other site 632772018027 active site 632772018028 substrate binding site [chemical binding]; other site 632772018029 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 632772018030 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 632772018031 Walker A/P-loop; other site 632772018032 ATP binding site [chemical binding]; other site 632772018033 Q-loop/lid; other site 632772018034 ABC transporter signature motif; other site 632772018035 Walker B; other site 632772018036 D-loop; other site 632772018037 H-loop/switch region; other site 632772018038 TOBE domain; Region: TOBE_2; pfam08402 632772018039 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 632772018040 5-dehydro-4-deoxyglucarate dehydratase; Provisional; Region: PRK03620 632772018041 catalytic residue [active] 632772018042 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 632772018043 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 632772018044 G1 box; other site 632772018045 putative GEF interaction site [polypeptide binding]; other site 632772018046 GTP/Mg2+ binding site [chemical binding]; other site 632772018047 Switch I region; other site 632772018048 G2 box; other site 632772018049 G3 box; other site 632772018050 Switch II region; other site 632772018051 G4 box; other site 632772018052 G5 box; other site 632772018053 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 632772018054 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 632772018055 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 632772018056 acyl-activating enzyme (AAE) consensus motif; other site 632772018057 active site 632772018058 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 632772018059 putative active site [active] 632772018060 catalytic residue [active] 632772018061 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 632772018062 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 632772018063 5S rRNA interface [nucleotide binding]; other site 632772018064 CTC domain interface [polypeptide binding]; other site 632772018065 L16 interface [polypeptide binding]; other site 632772018066 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cl03727 632772018067 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 632772018068 hypothetical protein; Validated; Region: PRK07121 632772018069 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 632772018070 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 632772018071 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 632772018072 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 632772018073 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 632772018074 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 632772018075 catalytic residue [active] 632772018076 ergothioneine biosynthesis glutamate--cysteine ligase EgtA; Region: EgtA_Cys_ligase; TIGR03444 632772018077 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 632772018078 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 632772018079 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 632772018080 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 632772018081 putative active site [active] 632772018082 putative dimer interface [polypeptide binding]; other site 632772018083 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 632772018084 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 632772018085 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 632772018086 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 632772018087 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 632772018088 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 632772018089 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 632772018090 hydroxyglutarate oxidase; Provisional; Region: PRK11728 632772018091 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 632772018092 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 632772018093 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 632772018094 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772018095 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 632772018096 hypothetical protein; Provisional; Region: PRK07524 632772018097 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 632772018098 PYR/PP interface [polypeptide binding]; other site 632772018099 dimer interface [polypeptide binding]; other site 632772018100 TPP binding site [chemical binding]; other site 632772018101 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 632772018102 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 632772018103 TPP-binding site [chemical binding]; other site 632772018104 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772018105 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772018106 active site 632772018107 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 632772018108 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 632772018109 NAD binding site [chemical binding]; other site 632772018110 catalytic residues [active] 632772018111 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772018112 short chain dehydrogenase; Provisional; Region: PRK07677 632772018113 NAD(P) binding site [chemical binding]; other site 632772018114 active site 632772018115 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 632772018116 CoA binding domain; Region: CoA_binding_2; pfam13380 632772018117 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 632772018118 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 632772018119 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772018120 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772018121 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 632772018122 Cytochrome P450; Region: p450; cl12078 632772018123 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 632772018124 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 632772018125 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 632772018126 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 632772018127 active site 632772018128 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 632772018129 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 632772018130 Substrate binding site; other site 632772018131 Mg++ binding site; other site 632772018132 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 632772018133 active site 632772018134 substrate binding site [chemical binding]; other site 632772018135 CoA binding site [chemical binding]; other site 632772018136 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772018137 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772018138 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772018139 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772018140 glutamate-1-semialdehyde 2,1-aminomutase; Provisional; Region: PRK06209 632772018141 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 632772018142 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 632772018143 catalytic residue [active] 632772018144 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 632772018145 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 632772018146 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 632772018147 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 632772018148 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 632772018149 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 632772018150 colanic acid exporter; Provisional; Region: PRK10459 632772018151 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 632772018152 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 632772018153 active site 632772018154 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 632772018155 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 632772018156 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 632772018157 NAD(P) binding site [chemical binding]; other site 632772018158 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 632772018159 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 632772018160 AAA domain; Region: AAA_31; pfam13614 632772018161 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 632772018162 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 632772018163 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 632772018164 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 632772018165 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 632772018166 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 632772018167 putative ADP-binding pocket [chemical binding]; other site 632772018168 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 632772018169 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 632772018170 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 632772018171 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 632772018172 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772018173 S-adenosylmethionine binding site [chemical binding]; other site 632772018174 Caenorhabditis protein of unknown function, DUF268; Region: DUF268; pfam03269 632772018175 TM1410 hypothetical-related protein; Region: DUF297; cl00997 632772018176 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 632772018177 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 632772018178 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 632772018179 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 632772018180 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 632772018181 Methyltransferase domain; Region: Methyltransf_23; pfam13489 632772018182 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 632772018183 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 632772018184 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 632772018185 extended (e) SDRs; Region: SDR_e; cd08946 632772018186 NAD(P) binding site [chemical binding]; other site 632772018187 active site 632772018188 substrate binding site [chemical binding]; other site 632772018189 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 632772018190 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 632772018191 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 632772018192 active site 632772018193 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 632772018194 Methyltransferase domain; Region: Methyltransf_23; pfam13489 632772018195 Methyltransferase domain; Region: Methyltransf_12; pfam08242 632772018196 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 632772018197 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 632772018198 hypothetical protein; Provisional; Region: PRK07877 632772018199 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 632772018200 ATP binding site [chemical binding]; other site 632772018201 substrate interface [chemical binding]; other site 632772018202 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 632772018203 FMN binding site [chemical binding]; other site 632772018204 dimer interface [polypeptide binding]; other site 632772018205 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 632772018206 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 632772018207 metal binding site [ion binding]; metal-binding site 632772018208 active site 632772018209 I-site; other site 632772018210 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 632772018211 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 632772018212 Bacterial sugar transferase; Region: Bac_transf; pfam02397 632772018213 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 632772018214 acyl carrier protein; Provisional; Region: PRK07081 632772018215 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772018216 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772018217 active site 632772018218 Gly_His_Pro_Ser_Thr_tRNA synthetase class II core domain. This domain is the core catalytic domain of tRNA synthetases of the subgroup containing glycyl, histidyl, prolyl, seryl and threonyl tRNA synthetases. It is primarily responsible for ATP-dependent...; Region: Gly_His_Pro_Ser_Thr_tRS_core; cd00670 632772018219 dimer interface [polypeptide binding]; other site 632772018220 motif 1; other site 632772018221 active site 632772018222 motif 2; other site 632772018223 motif 3; other site 632772018224 Domain of unknown function (DUF1839); Region: DUF1839; pfam08893 632772018225 Domain of unknown function (DUF1839); Region: DUF1839; pfam08893 632772018226 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 632772018227 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 632772018228 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 632772018229 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 632772018230 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 632772018231 ATP binding site [chemical binding]; other site 632772018232 putative Mg++ binding site [ion binding]; other site 632772018233 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 632772018234 nucleotide binding region [chemical binding]; other site 632772018235 ATP-binding site [chemical binding]; other site 632772018236 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 632772018237 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 632772018238 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 632772018239 homodimer interface [polypeptide binding]; other site 632772018240 metal binding site [ion binding]; metal-binding site 632772018241 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 632772018242 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 632772018243 Ligand binding site; other site 632772018244 Putative Catalytic site; other site 632772018245 DXD motif; other site 632772018246 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 632772018247 active site 632772018248 N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476 632772018249 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 632772018250 active site 632772018251 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 632772018252 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 632772018253 active site 632772018254 catalytic residues [active] 632772018255 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 632772018256 active site 632772018257 catalytic residues [active] 632772018258 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 632772018259 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 632772018260 metal binding site [ion binding]; metal-binding site 632772018261 active site 632772018262 I-site; other site 632772018263 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 632772018264 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 632772018265 metal binding site [ion binding]; metal-binding site 632772018266 active site 632772018267 I-site; other site 632772018268 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 632772018269 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 632772018270 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 632772018271 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 632772018272 Imelysin; Region: Peptidase_M75; pfam09375 632772018273 Iron permease FTR1 family; Region: FTR1; cl00475 632772018274 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 632772018275 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 632772018276 N-acetyl-D-glucosamine binding site [chemical binding]; other site 632772018277 enolase; Provisional; Region: eno; PRK00077 632772018278 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 632772018279 dimer interface [polypeptide binding]; other site 632772018280 metal binding site [ion binding]; metal-binding site 632772018281 substrate binding pocket [chemical binding]; other site 632772018282 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 632772018283 Septum formation initiator; Region: DivIC; pfam04977 632772018284 Uncharacterized conserved protein [Function unknown]; Region: COG1507 632772018285 exopolyphosphatase; Region: exo_poly_only; TIGR03706 632772018286 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 632772018287 Methyltransferase domain; Region: Methyltransf_31; pfam13847 632772018288 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772018289 S-adenosylmethionine binding site [chemical binding]; other site 632772018290 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 632772018291 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632772018292 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 632772018293 MarR family; Region: MarR; pfam01047 632772018294 MarR family; Region: MarR_2; cl17246 632772018295 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 632772018296 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772018297 NAD(P) binding site [chemical binding]; other site 632772018298 active site 632772018299 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 632772018300 classical (c) SDRs; Region: SDR_c; cd05233 632772018301 NAD(P) binding site [chemical binding]; other site 632772018302 active site 632772018303 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772018304 NAD(P) binding site [chemical binding]; other site 632772018305 active site 632772018306 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772018307 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 632772018308 SnoaL-like domain; Region: SnoaL_4; pfam13577 632772018309 SnoaL-like domain; Region: SnoaL_3; pfam13474 632772018310 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 632772018311 Transcriptional regulator [Transcription]; Region: IclR; COG1414 632772018312 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 632772018313 Bacterial transcriptional regulator; Region: IclR; pfam01614 632772018314 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 632772018315 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 632772018316 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 632772018317 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12835 632772018318 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 632772018319 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 632772018320 acetaldehyde dehydrogenase; Validated; Region: PRK08300 632772018321 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 632772018322 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 632772018323 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 632772018324 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 632772018325 active site 632772018326 catalytic residues [active] 632772018327 metal binding site [ion binding]; metal-binding site 632772018328 DmpG-like communication domain; Region: DmpG_comm; pfam07836 632772018329 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772018330 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772018331 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 632772018332 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 632772018333 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 632772018334 active site 632772018335 Fe binding site [ion binding]; other site 632772018336 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 632772018337 Secretory lipase; Region: LIP; pfam03583 632772018338 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 632772018339 Domain of unknown function (DUF427); Region: DUF427; cl00998 632772018340 Domain of unknown function (DUF427); Region: DUF427; pfam04248 632772018341 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 632772018342 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 632772018343 Serine hydrolase; Region: Ser_hydrolase; cl17834 632772018344 potential frameshift: common BLAST hit: gi|111022772|ref|YP_705744.1| 3-oxoacyl-[acyl-carrier-protein] reductase 632772018345 classical (c) SDRs; Region: SDR_c; cd05233 632772018346 NAD(P) binding site [chemical binding]; other site 632772018347 active site 632772018348 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772018349 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772018350 short chain dehydrogenase; Provisional; Region: PRK07454 632772018351 NAD(P) binding site [chemical binding]; other site 632772018352 active site 632772018353 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 632772018354 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 632772018355 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772018356 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772018357 active site 632772018358 3-ketosteroid-delta-1-dehydrogenase; Provisional; Region: PRK12837 632772018359 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 632772018360 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772018361 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772018362 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 632772018363 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 632772018364 dimer interface [polypeptide binding]; other site 632772018365 active site 632772018366 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772018367 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772018368 active site 632772018369 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772018370 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772018371 active site 632772018372 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 632772018373 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 632772018374 dimer interaction site [polypeptide binding]; other site 632772018375 substrate-binding tunnel; other site 632772018376 active site 632772018377 catalytic site [active] 632772018378 substrate binding site [chemical binding]; other site 632772018379 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 632772018380 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 632772018381 CoenzymeA binding site [chemical binding]; other site 632772018382 subunit interaction site [polypeptide binding]; other site 632772018383 PHB binding site; other site 632772018384 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 632772018385 classical (c) SDRs; Region: SDR_c; cd05233 632772018386 NAD(P) binding site [chemical binding]; other site 632772018387 active site 632772018388 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 632772018389 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772018390 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 632772018391 acyl-activating enzyme (AAE) consensus motif; other site 632772018392 acyl-activating enzyme (AAE) consensus motif; other site 632772018393 putative AMP binding site [chemical binding]; other site 632772018394 putative active site [active] 632772018395 putative CoA binding site [chemical binding]; other site 632772018396 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 632772018397 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 632772018398 active site 632772018399 FMN binding site [chemical binding]; other site 632772018400 substrate binding site [chemical binding]; other site 632772018401 putative catalytic residue [active] 632772018402 acyl-CoA synthetase; Provisional; Region: PRK13388 632772018403 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772018404 acyl-activating enzyme (AAE) consensus motif; other site 632772018405 AMP binding site [chemical binding]; other site 632772018406 active site 632772018407 CoA binding site [chemical binding]; other site 632772018408 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 632772018409 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 632772018410 SnoaL-like domain; Region: SnoaL_4; pfam13577 632772018411 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772018412 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772018413 active site 632772018414 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 632772018415 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 632772018416 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 632772018417 DUF35 OB-fold domain; Region: DUF35; pfam01796 632772018418 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772018419 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772018420 active site 632772018421 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 632772018422 putative active site [active] 632772018423 putative catalytic site [active] 632772018424 lipid-transfer protein; Provisional; Region: PRK07855 632772018425 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 632772018426 active site 632772018427 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 632772018428 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 632772018429 active site 2 [active] 632772018430 active site 1 [active] 632772018431 short chain dehydrogenase; Provisional; Region: PRK07856 632772018432 classical (c) SDRs; Region: SDR_c; cd05233 632772018433 NAD(P) binding site [chemical binding]; other site 632772018434 active site 632772018435 short chain dehydrogenase; Provisional; Region: PRK08226 632772018436 classical (c) SDRs; Region: SDR_c; cd05233 632772018437 NAD(P) binding site [chemical binding]; other site 632772018438 active site 632772018439 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 632772018440 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 632772018441 FAD binding pocket [chemical binding]; other site 632772018442 FAD binding motif [chemical binding]; other site 632772018443 phosphate binding motif [ion binding]; other site 632772018444 beta-alpha-beta structure motif; other site 632772018445 NAD(p) ribose binding residues [chemical binding]; other site 632772018446 NAD binding pocket [chemical binding]; other site 632772018447 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 632772018448 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 632772018449 catalytic loop [active] 632772018450 iron binding site [ion binding]; other site 632772018451 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 632772018452 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 632772018453 putative active site [active] 632772018454 putative dimer interface [polypeptide binding]; other site 632772018455 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 632772018456 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 632772018457 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 632772018458 Catalytic domain of Protein Kinases; Region: PKc; cd00180 632772018459 active site 632772018460 ATP binding site [chemical binding]; other site 632772018461 substrate binding site [chemical binding]; other site 632772018462 activation loop (A-loop); other site 632772018463 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 632772018464 AAA ATPase domain; Region: AAA_16; pfam13191 632772018465 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 632772018466 putative FMN binding site [chemical binding]; other site 632772018467 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 632772018468 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772018469 S-adenosylmethionine binding site [chemical binding]; other site 632772018470 Bax inhibitor 1 like; Region: BaxI_1; cl17691 632772018471 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 632772018472 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 632772018473 dimer interface [polypeptide binding]; other site 632772018474 active site 632772018475 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 632772018476 active site 632772018477 catalytic triad [active] 632772018478 oxyanion hole [active] 632772018479 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 632772018480 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 632772018481 dimer interface [polypeptide binding]; other site 632772018482 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632772018483 catalytic residue [active] 632772018484 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 632772018485 cystathionine gamma-synthase; Provisional; Region: PRK07811 632772018486 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 632772018487 homodimer interface [polypeptide binding]; other site 632772018488 substrate-cofactor binding pocket; other site 632772018489 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632772018490 catalytic residue [active] 632772018491 threonine dehydratase; Provisional; Region: PRK08198 632772018492 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 632772018493 tetramer interface [polypeptide binding]; other site 632772018494 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632772018495 catalytic residue [active] 632772018496 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 632772018497 ApbE family; Region: ApbE; pfam02424 632772018498 SEC-C motif; Region: SEC-C; pfam02810 632772018499 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 632772018500 N-acetyl-D-glucosamine binding site [chemical binding]; other site 632772018501 catalytic residue [active] 632772018502 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 632772018503 NlpC/P60 family; Region: NLPC_P60; pfam00877 632772018504 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 632772018505 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 632772018506 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 632772018507 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 632772018508 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 632772018509 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 632772018510 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 632772018511 catalytic residues [active] 632772018512 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 632772018513 putative active cleft [active] 632772018514 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 632772018515 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 632772018516 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 632772018517 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 632772018518 catalytic residue [active] 632772018519 putative FPP diphosphate binding site; other site 632772018520 putative FPP binding hydrophobic cleft; other site 632772018521 dimer interface [polypeptide binding]; other site 632772018522 putative IPP diphosphate binding site; other site 632772018523 pantothenate kinase; Provisional; Region: PRK05439 632772018524 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 632772018525 ATP-binding site [chemical binding]; other site 632772018526 CoA-binding site [chemical binding]; other site 632772018527 Mg2+-binding site [ion binding]; other site 632772018528 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 632772018529 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 632772018530 dimer interface [polypeptide binding]; other site 632772018531 active site 632772018532 glycine-pyridoxal phosphate binding site [chemical binding]; other site 632772018533 folate binding site [chemical binding]; other site 632772018534 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 632772018535 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 632772018536 putative active site [active] 632772018537 PhoH-like protein; Region: PhoH; pfam02562 632772018538 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 632772018539 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 632772018540 Beta-lactamase; Region: Beta-lactamase; pfam00144 632772018541 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 632772018542 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 632772018543 dinuclear metal binding motif [ion binding]; other site 632772018544 fumarate hydratase; Reviewed; Region: fumC; PRK00485 632772018545 Class II fumarases; Region: Fumarase_classII; cd01362 632772018546 active site 632772018547 tetramer interface [polypeptide binding]; other site 632772018548 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 632772018549 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 632772018550 putative active site [active] 632772018551 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 632772018552 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 632772018553 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 632772018554 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 632772018555 generic binding surface II; other site 632772018556 generic binding surface I; other site 632772018557 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 632772018558 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 632772018559 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 632772018560 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 632772018561 active site 632772018562 metal binding site [ion binding]; metal-binding site 632772018563 DNA binding site [nucleotide binding] 632772018564 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 632772018565 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 632772018566 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632772018567 Walker A/P-loop; other site 632772018568 ATP binding site [chemical binding]; other site 632772018569 Q-loop/lid; other site 632772018570 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632772018571 Walker B; other site 632772018572 D-loop; other site 632772018573 H-loop/switch region; other site 632772018574 Domain of unknown function DUF20; Region: UPF0118; pfam01594 632772018575 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 632772018576 Protein of unknown function (DUF466); Region: DUF466; pfam04328 632772018577 carbon starvation protein A; Provisional; Region: PRK15015 632772018578 Carbon starvation protein CstA; Region: CstA; pfam02554 632772018579 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 632772018580 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 632772018581 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 632772018582 active site 632772018583 FMN binding site [chemical binding]; other site 632772018584 substrate binding site [chemical binding]; other site 632772018585 3Fe-4S cluster binding site [ion binding]; other site 632772018586 Interferon-induced transmembrane protein; Region: CD225; pfam04505 632772018587 GTP-binding protein YchF; Reviewed; Region: PRK09601 632772018588 YchF GTPase; Region: YchF; cd01900 632772018589 G1 box; other site 632772018590 GTP/Mg2+ binding site [chemical binding]; other site 632772018591 Switch I region; other site 632772018592 G2 box; other site 632772018593 Switch II region; other site 632772018594 G3 box; other site 632772018595 G4 box; other site 632772018596 G5 box; other site 632772018597 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 632772018598 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772018599 putative substrate translocation pore; other site 632772018600 Predicted transcriptional regulators [Transcription]; Region: COG1733 632772018601 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 632772018602 PE-PPE domain; Region: PE-PPE; pfam08237 632772018603 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 632772018604 Cupin domain; Region: Cupin_2; cl17218 632772018605 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632772018606 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632772018607 DNA binding residues [nucleotide binding] 632772018608 dimerization interface [polypeptide binding]; other site 632772018609 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 632772018610 elongation factor G; Reviewed; Region: PRK12740 632772018611 G1 box; other site 632772018612 putative GEF interaction site [polypeptide binding]; other site 632772018613 GTP/Mg2+ binding site [chemical binding]; other site 632772018614 Switch I region; other site 632772018615 G2 box; other site 632772018616 G3 box; other site 632772018617 Switch II region; other site 632772018618 G4 box; other site 632772018619 G5 box; other site 632772018620 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 632772018621 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 632772018622 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 632772018623 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 632772018624 putative hydrophobic ligand binding site [chemical binding]; other site 632772018625 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 632772018626 putative active site [active] 632772018627 putative metal binding site [ion binding]; other site 632772018628 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 632772018629 Fic/DOC family; Region: Fic; cl00960 632772018630 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 632772018631 heat shock protein 90; Provisional; Region: PRK05218 632772018632 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632772018633 ATP binding site [chemical binding]; other site 632772018634 Mg2+ binding site [ion binding]; other site 632772018635 G-X-G motif; other site 632772018636 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 632772018637 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772018638 NAD(P) binding site [chemical binding]; other site 632772018639 active site 632772018640 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 632772018641 active site 632772018642 SUMO-1 interface [polypeptide binding]; other site 632772018643 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772018644 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772018645 active site 632772018646 Methyltransferase domain; Region: Methyltransf_31; pfam13847 632772018647 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772018648 S-adenosylmethionine binding site [chemical binding]; other site 632772018649 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 632772018650 fumarate hydratase; Provisional; Region: PRK15389 632772018651 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 632772018652 Fumarase C-terminus; Region: Fumerase_C; pfam05683 632772018653 CAAX protease self-immunity; Region: Abi; pfam02517 632772018654 PGAP1-like protein; Region: PGAP1; pfam07819 632772018655 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 632772018656 ligand binding site [chemical binding]; other site 632772018657 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 632772018658 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 632772018659 putative active site [active] 632772018660 putative FMN binding site [chemical binding]; other site 632772018661 putative substrate binding site [chemical binding]; other site 632772018662 putative catalytic residue [active] 632772018663 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 632772018664 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 632772018665 active site 632772018666 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 632772018667 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 632772018668 Cl- selectivity filter; other site 632772018669 Cl- binding residues [ion binding]; other site 632772018670 pore gating glutamate residue; other site 632772018671 dimer interface [polypeptide binding]; other site 632772018672 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 632772018673 Mrr N-terminal domain; Region: Mrr_N; pfam14338 632772018674 Restriction endonuclease; Region: Mrr_cat; pfam04471 632772018675 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 632772018676 Beta-lactamase; Region: Beta-lactamase; pfam00144 632772018677 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 632772018678 active site 632772018679 phosphorylation site [posttranslational modification] 632772018680 intermolecular recognition site; other site 632772018681 dimerization interface [polypeptide binding]; other site 632772018682 NADH dehydrogenase subunit A; Validated; Region: PRK07928 632772018683 NADH dehydrogenase subunit B; Validated; Region: PRK06411 632772018684 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 632772018685 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 632772018686 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 632772018687 NADH dehydrogenase subunit D; Validated; Region: PRK06075 632772018688 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 632772018689 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 632772018690 putative dimer interface [polypeptide binding]; other site 632772018691 [2Fe-2S] cluster binding site [ion binding]; other site 632772018692 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 632772018693 SLBB domain; Region: SLBB; pfam10531 632772018694 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 632772018695 NADH dehydrogenase subunit G; Validated; Region: PRK07860 632772018696 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 632772018697 catalytic loop [active] 632772018698 iron binding site [ion binding]; other site 632772018699 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 632772018700 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 632772018701 molybdopterin cofactor binding site; other site 632772018702 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 632772018703 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 632772018704 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 632772018705 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 632772018706 4Fe-4S binding domain; Region: Fer4; pfam00037 632772018707 4Fe-4S binding domain; Region: Fer4; pfam00037 632772018708 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 632772018709 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 632772018710 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 632772018711 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 632772018712 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 632772018713 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 632772018714 proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972 632772018715 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 632772018716 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 632772018717 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 632772018718 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 632772018719 SnoaL-like domain; Region: SnoaL_4; pfam13577 632772018720 Transcriptional regulators [Transcription]; Region: MarR; COG1846 632772018721 MarR family; Region: MarR_2; cl17246 632772018722 mannosyltransferase; Provisional; Region: pimE; PRK13375 632772018723 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 632772018724 aromatic arch; other site 632772018725 DCoH dimer interaction site [polypeptide binding]; other site 632772018726 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 632772018727 DCoH tetramer interaction site [polypeptide binding]; other site 632772018728 substrate binding site [chemical binding]; other site 632772018729 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 632772018730 active site 632772018731 8-oxo-dGMP binding site [chemical binding]; other site 632772018732 nudix motif; other site 632772018733 metal binding site [ion binding]; metal-binding site 632772018734 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 632772018735 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 632772018736 G1 box; other site 632772018737 putative GEF interaction site [polypeptide binding]; other site 632772018738 GTP/Mg2+ binding site [chemical binding]; other site 632772018739 Switch I region; other site 632772018740 G2 box; other site 632772018741 G3 box; other site 632772018742 Switch II region; other site 632772018743 G4 box; other site 632772018744 G5 box; other site 632772018745 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 632772018746 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 632772018747 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 632772018748 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 632772018749 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 632772018750 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 632772018751 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 632772018752 tetramer interface [polypeptide binding]; other site 632772018753 heme binding pocket [chemical binding]; other site 632772018754 NADPH binding site [chemical binding]; other site 632772018755 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 632772018756 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 632772018757 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 632772018758 active site 632772018759 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 632772018760 Fe-S cluster binding site [ion binding]; other site 632772018761 DNA binding site [nucleotide binding] 632772018762 active site 632772018763 Predicted membrane protein [Function unknown]; Region: COG3428 632772018764 Bacterial PH domain; Region: DUF304; pfam03703 632772018765 Bacterial PH domain; Region: DUF304; cl01348 632772018766 FO synthase; Reviewed; Region: fbiC; PRK09234 632772018767 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632772018768 FeS/SAM binding site; other site 632772018769 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632772018770 FeS/SAM binding site; other site 632772018771 Ferredoxin [Energy production and conversion]; Region: COG1146 632772018772 4Fe-4S binding domain; Region: Fer4; pfam00037 632772018773 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 632772018774 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 632772018775 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632772018776 homodimer interface [polypeptide binding]; other site 632772018777 catalytic residue [active] 632772018778 PPOX class probable F420-dependent enzyme, MSMEG_5819 family; Region: PPOX_MSMEG_5819; TIGR04023 632772018779 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 632772018780 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 632772018781 Glutamate binding site [chemical binding]; other site 632772018782 NAD binding site [chemical binding]; other site 632772018783 catalytic residues [active] 632772018784 Proline dehydrogenase; Region: Pro_dh; cl03282 632772018785 acyl-CoA synthetase; Validated; Region: PRK07787 632772018786 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772018787 acyl-activating enzyme (AAE) consensus motif; other site 632772018788 AMP binding site [chemical binding]; other site 632772018789 active site 632772018790 CoA binding site [chemical binding]; other site 632772018791 Prostaglandin dehydrogenases; Region: PGDH; cd05288 632772018792 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 632772018793 NAD(P) binding site [chemical binding]; other site 632772018794 substrate binding site [chemical binding]; other site 632772018795 dimer interface [polypeptide binding]; other site 632772018796 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 632772018797 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 632772018798 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 632772018799 metal ion-dependent adhesion site (MIDAS); other site 632772018800 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 632772018801 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 632772018802 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 632772018803 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 632772018804 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 632772018805 putative trimer interface [polypeptide binding]; other site 632772018806 putative CoA binding site [chemical binding]; other site 632772018807 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 632772018808 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 632772018809 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 632772018810 metal binding site [ion binding]; metal-binding site 632772018811 putative dimer interface [polypeptide binding]; other site 632772018812 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 632772018813 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 632772018814 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 632772018815 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 632772018816 acyl-activating enzyme (AAE) consensus motif; other site 632772018817 putative AMP binding site [chemical binding]; other site 632772018818 putative active site [active] 632772018819 putative CoA binding site [chemical binding]; other site 632772018820 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 632772018821 dihydropteroate synthase; Region: DHPS; TIGR01496 632772018822 substrate binding pocket [chemical binding]; other site 632772018823 dimer interface [polypeptide binding]; other site 632772018824 inhibitor binding site; inhibition site 632772018825 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 632772018826 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 632772018827 DivIVA domain; Region: DivI1A_domain; TIGR03544 632772018828 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 632772018829 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 632772018830 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 632772018831 Methyltransferase domain; Region: Methyltransf_11; pfam08241 632772018832 S-adenosylmethionine binding site [chemical binding]; other site 632772018833 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 632772018834 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 632772018835 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 632772018836 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 632772018837 ligand binding site; other site 632772018838 oligomer interface; other site 632772018839 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 632772018840 dimer interface [polypeptide binding]; other site 632772018841 N-terminal domain interface [polypeptide binding]; other site 632772018842 sulfate 1 binding site; other site 632772018843 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 632772018844 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772018845 S-adenosylmethionine binding site [chemical binding]; other site 632772018846 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 632772018847 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632772018848 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 632772018849 DNA binding residues [nucleotide binding] 632772018850 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 632772018851 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 632772018852 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 632772018853 protein binding site [polypeptide binding]; other site 632772018854 sec-independent translocase; Provisional; Region: PRK03100 632772018855 Domain of unknown function DUF59; Region: DUF59; cl00941 632772018856 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 632772018857 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 632772018858 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 632772018859 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 632772018860 N-acetyl-D-glucosamine binding site [chemical binding]; other site 632772018861 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 632772018862 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 632772018863 N-acetyl-D-glucosamine binding site [chemical binding]; other site 632772018864 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 632772018865 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 632772018866 PRC-barrel domain; Region: PRC; pfam05239 632772018867 MgtE intracellular N domain; Region: MgtE_N; smart00924 632772018868 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 632772018869 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 632772018870 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 632772018871 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 632772018872 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 632772018873 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772018874 dimer interface [polypeptide binding]; other site 632772018875 conserved gate region; other site 632772018876 putative PBP binding loops; other site 632772018877 ABC-ATPase subunit interface; other site 632772018878 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 632772018879 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772018880 dimer interface [polypeptide binding]; other site 632772018881 conserved gate region; other site 632772018882 putative PBP binding loops; other site 632772018883 ABC-ATPase subunit interface; other site 632772018884 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 632772018885 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 632772018886 Walker A/P-loop; other site 632772018887 ATP binding site [chemical binding]; other site 632772018888 Q-loop/lid; other site 632772018889 ABC transporter signature motif; other site 632772018890 Walker B; other site 632772018891 D-loop; other site 632772018892 H-loop/switch region; other site 632772018893 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772018894 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632772018895 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 632772018896 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 632772018897 active site 632772018898 metal binding site [ion binding]; metal-binding site 632772018899 Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403 632772018900 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 632772018901 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 632772018902 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 632772018903 oligomer interface [polypeptide binding]; other site 632772018904 metal binding site [ion binding]; metal-binding site 632772018905 metal binding site [ion binding]; metal-binding site 632772018906 putative Cl binding site [ion binding]; other site 632772018907 basic sphincter; other site 632772018908 hydrophobic gate; other site 632772018909 periplasmic entrance; other site 632772018910 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 632772018911 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 632772018912 active site 632772018913 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 632772018914 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 632772018915 Malic enzyme, N-terminal domain; Region: malic; pfam00390 632772018916 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 632772018917 NAD(P) binding pocket [chemical binding]; other site 632772018918 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 632772018919 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772018920 ABC-ATPase subunit interface; other site 632772018921 putative PBP binding loops; other site 632772018922 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 632772018923 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 632772018924 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 632772018925 Walker A/P-loop; other site 632772018926 ATP binding site [chemical binding]; other site 632772018927 Q-loop/lid; other site 632772018928 ABC transporter signature motif; other site 632772018929 Walker B; other site 632772018930 D-loop; other site 632772018931 H-loop/switch region; other site 632772018932 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 632772018933 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 632772018934 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 632772018935 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 632772018936 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772018937 short chain dehydrogenase; Provisional; Region: PRK07832 632772018938 NAD(P) binding site [chemical binding]; other site 632772018939 active site 632772018940 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 632772018941 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 632772018942 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772018943 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772018944 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 632772018945 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 632772018946 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 632772018947 TPP-binding site [chemical binding]; other site 632772018948 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 632772018949 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 632772018950 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 632772018951 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632772018952 Walker A/P-loop; other site 632772018953 ATP binding site [chemical binding]; other site 632772018954 Q-loop/lid; other site 632772018955 ABC transporter signature motif; other site 632772018956 Walker B; other site 632772018957 D-loop; other site 632772018958 H-loop/switch region; other site 632772018959 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 632772018960 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 632772018961 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632772018962 Walker A/P-loop; other site 632772018963 ATP binding site [chemical binding]; other site 632772018964 Q-loop/lid; other site 632772018965 ABC transporter signature motif; other site 632772018966 Walker B; other site 632772018967 D-loop; other site 632772018968 H-loop/switch region; other site 632772018969 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 632772018970 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 632772018971 Walker A/P-loop; other site 632772018972 ATP binding site [chemical binding]; other site 632772018973 Q-loop/lid; other site 632772018974 ABC transporter signature motif; other site 632772018975 Walker B; other site 632772018976 D-loop; other site 632772018977 H-loop/switch region; other site 632772018978 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 632772018979 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 632772018980 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 632772018981 catalytic residue [active] 632772018982 Helix-turn-helix domain; Region: HTH_18; pfam12833 632772018983 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 632772018984 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 632772018985 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 632772018986 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 632772018987 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 632772018988 putative dimer interface [polypeptide binding]; other site 632772018989 N-terminal domain interface [polypeptide binding]; other site 632772018990 putative substrate binding pocket (H-site) [chemical binding]; other site 632772018991 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 632772018992 Predicted transcriptional regulators [Transcription]; Region: COG1695 632772018993 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 632772018994 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772018995 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632772018996 putative substrate translocation pore; other site 632772018997 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 632772018998 FAD binding domain; Region: FAD_binding_4; pfam01565 632772018999 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 632772019000 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772019001 substrate binding site [chemical binding]; other site 632772019002 oxyanion hole (OAH) forming residues; other site 632772019003 trimer interface [polypeptide binding]; other site 632772019004 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772019005 AMP-binding enzyme; Region: AMP-binding; pfam00501 632772019006 acyl-activating enzyme (AAE) consensus motif; other site 632772019007 active site 632772019008 AMP binding site [chemical binding]; other site 632772019009 CoA binding site [chemical binding]; other site 632772019010 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 632772019011 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 632772019012 active site 632772019013 purine riboside binding site [chemical binding]; other site 632772019014 Amidase; Region: Amidase; cl11426 632772019015 indole-3-acetamide amidohydrolase; Region: PLN02722 632772019016 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 632772019017 FAD binding domain; Region: FAD_binding_4; pfam01565 632772019018 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 632772019019 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772019020 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772019021 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 632772019022 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 632772019023 dimer interface [polypeptide binding]; other site 632772019024 active site 632772019025 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 632772019026 substrate binding site [chemical binding]; other site 632772019027 catalytic residue [active] 632772019028 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 632772019029 RNase_H superfamily; Region: RNase_H_2; pfam13482 632772019030 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 632772019031 AAA domain; Region: AAA_30; pfam13604 632772019032 AAA domain; Region: AAA_12; pfam13087 632772019033 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 632772019034 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 632772019035 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 632772019036 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 632772019037 acyl-activating enzyme (AAE) consensus motif; other site 632772019038 putative AMP binding site [chemical binding]; other site 632772019039 putative active site [active] 632772019040 putative CoA binding site [chemical binding]; other site 632772019041 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 632772019042 Predicted amidohydrolase [General function prediction only]; Region: COG0388 632772019043 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 632772019044 putative active site [active] 632772019045 catalytic triad [active] 632772019046 putative dimer interface [polypeptide binding]; other site 632772019047 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 632772019048 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 632772019049 ATP binding site [chemical binding]; other site 632772019050 Mg++ binding site [ion binding]; other site 632772019051 motif III; other site 632772019052 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 632772019053 nucleotide binding region [chemical binding]; other site 632772019054 ATP-binding site [chemical binding]; other site 632772019055 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 632772019056 putative RNA binding site [nucleotide binding]; other site 632772019057 Protein of unknown function (DUF664); Region: DUF664; pfam04978 632772019058 DinB superfamily; Region: DinB_2; pfam12867 632772019059 trehalose synthase; Region: treS_nterm; TIGR02456 632772019060 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 632772019061 active site 632772019062 catalytic site [active] 632772019063 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 632772019064 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 632772019065 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 632772019066 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 632772019067 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632772019068 Walker A/P-loop; other site 632772019069 ATP binding site [chemical binding]; other site 632772019070 Q-loop/lid; other site 632772019071 ABC transporter signature motif; other site 632772019072 Walker B; other site 632772019073 D-loop; other site 632772019074 H-loop/switch region; other site 632772019075 hypothetical protein; Provisional; Region: PRK04233 632772019076 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 632772019077 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772019078 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 632772019079 acyl-activating enzyme (AAE) consensus motif; other site 632772019080 acyl-activating enzyme (AAE) consensus motif; other site 632772019081 putative AMP binding site [chemical binding]; other site 632772019082 putative active site [active] 632772019083 putative CoA binding site [chemical binding]; other site 632772019084 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 632772019085 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 632772019086 Walker A/P-loop; other site 632772019087 ATP binding site [chemical binding]; other site 632772019088 Q-loop/lid; other site 632772019089 ABC transporter signature motif; other site 632772019090 Walker B; other site 632772019091 D-loop; other site 632772019092 H-loop/switch region; other site 632772019093 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 632772019094 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 632772019095 FtsX-like permease family; Region: FtsX; pfam02687 632772019096 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 632772019097 FtsX-like permease family; Region: FtsX; pfam02687 632772019098 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 632772019099 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 632772019100 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 632772019101 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 632772019102 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772019103 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772019104 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 632772019105 A new structural DNA glycosylase; Region: AlkD_like; cd06561 632772019106 active site 632772019107 Uncharacterized protein conserved in bacteria (DUF2272); Region: DUF2272; cl01776 632772019108 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 632772019109 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 632772019110 FAD binding pocket [chemical binding]; other site 632772019111 FAD binding motif [chemical binding]; other site 632772019112 phosphate binding motif [ion binding]; other site 632772019113 beta-alpha-beta structure motif; other site 632772019114 NAD(p) ribose binding residues [chemical binding]; other site 632772019115 NAD binding pocket [chemical binding]; other site 632772019116 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 632772019117 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 632772019118 catalytic loop [active] 632772019119 iron binding site [ion binding]; other site 632772019120 NDMA-dependent methanol dehydrogenase; Region: NDMA_methanol; TIGR04266 632772019121 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 632772019122 dimer interface [polypeptide binding]; other site 632772019123 active site 632772019124 metal binding site [ion binding]; metal-binding site 632772019125 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 632772019126 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632772019127 Walker A motif; other site 632772019128 ATP binding site [chemical binding]; other site 632772019129 Walker B motif; other site 632772019130 arginine finger; other site 632772019131 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 632772019132 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH4; cd08188 632772019133 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 632772019134 putative active site [active] 632772019135 metal binding site [ion binding]; metal-binding site 632772019136 GAF domain; Region: GAF_3; pfam13492 632772019137 GAF domain; Region: GAF_2; pfam13185 632772019138 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 632772019139 Histidine kinase; Region: HisKA_3; pfam07730 632772019140 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 632772019141 ATP binding site [chemical binding]; other site 632772019142 Mg2+ binding site [ion binding]; other site 632772019143 G-X-G motif; other site 632772019144 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632772019145 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632772019146 active site 632772019147 phosphorylation site [posttranslational modification] 632772019148 intermolecular recognition site; other site 632772019149 dimerization interface [polypeptide binding]; other site 632772019150 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632772019151 DNA binding residues [nucleotide binding] 632772019152 dimerization interface [polypeptide binding]; other site 632772019153 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 632772019154 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 632772019155 Walker A/P-loop; other site 632772019156 ATP binding site [chemical binding]; other site 632772019157 Q-loop/lid; other site 632772019158 ABC transporter signature motif; other site 632772019159 Walker B; other site 632772019160 D-loop; other site 632772019161 H-loop/switch region; other site 632772019162 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 632772019163 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 632772019164 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 632772019165 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 632772019166 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 632772019167 NAD binding site [chemical binding]; other site 632772019168 Domain of unknown function (DUF222); Region: DUF222; pfam02720 632772019169 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 632772019170 active site 632772019171 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772019172 S-adenosylmethionine binding site [chemical binding]; other site 632772019173 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 632772019174 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772019175 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 632772019176 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 632772019177 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632772019178 FeS/SAM binding site; other site 632772019179 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 632772019180 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 632772019181 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 632772019182 phosphate binding site [ion binding]; other site 632772019183 mycofactocin system FadH/OYE family oxidoreductase 1; Region: mycofact_OYE_1; TIGR03996 632772019184 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 632772019185 phosphate binding site [ion binding]; other site 632772019186 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 632772019187 classical (c) SDRs; Region: SDR_c; cd05233 632772019188 NAD(P) binding site [chemical binding]; other site 632772019189 active site 632772019190 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 632772019191 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 632772019192 putative active site [active] 632772019193 putative FMN binding site [chemical binding]; other site 632772019194 putative substrate binding site [chemical binding]; other site 632772019195 putative catalytic residue [active] 632772019196 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 632772019197 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 632772019198 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 632772019199 Probable Catalytic site; other site 632772019200 metal-binding site 632772019201 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 632772019202 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 632772019203 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 632772019204 DNA binding site [nucleotide binding] 632772019205 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 632772019206 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 632772019207 NAD(P) binding site [chemical binding]; other site 632772019208 catalytic residues [active] 632772019209 Protein of unknown function (DUF779); Region: DUF779; pfam05610 632772019210 ethanolamine permease; Region: 2A0305; TIGR00908 632772019211 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 632772019212 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 632772019213 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 632772019214 metabolite-proton symporter; Region: 2A0106; TIGR00883 632772019215 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772019216 putative substrate translocation pore; other site 632772019217 AMP-binding domain protein; Validated; Region: PRK08315 632772019218 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772019219 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 632772019220 acyl-activating enzyme (AAE) consensus motif; other site 632772019221 putative AMP binding site [chemical binding]; other site 632772019222 putative active site [active] 632772019223 putative CoA binding site [chemical binding]; other site 632772019224 Domain of unknown function (DUF336); Region: DUF336; pfam03928 632772019225 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 632772019226 Histidine kinase; Region: HisKA_3; pfam07730 632772019227 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632772019228 ATP binding site [chemical binding]; other site 632772019229 Mg2+ binding site [ion binding]; other site 632772019230 G-X-G motif; other site 632772019231 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632772019232 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632772019233 active site 632772019234 phosphorylation site [posttranslational modification] 632772019235 intermolecular recognition site; other site 632772019236 dimerization interface [polypeptide binding]; other site 632772019237 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632772019238 DNA binding residues [nucleotide binding] 632772019239 dimerization interface [polypeptide binding]; other site 632772019240 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 632772019241 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772019242 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772019243 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 632772019244 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 632772019245 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 632772019246 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 632772019247 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 632772019248 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 632772019249 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 632772019250 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 632772019251 carboxyltransferase (CT) interaction site; other site 632772019252 biotinylation site [posttranslational modification]; other site 632772019253 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772019254 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772019255 active site 632772019256 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 632772019257 putative active site [active] 632772019258 putative catalytic site [active] 632772019259 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 632772019260 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 632772019261 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 632772019262 acyl-activating enzyme (AAE) consensus motif; other site 632772019263 putative AMP binding site [chemical binding]; other site 632772019264 putative active site [active] 632772019265 putative CoA binding site [chemical binding]; other site 632772019266 Condensation domain; Region: Condensation; pfam00668 632772019267 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772019268 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 632772019269 acyl-activating enzyme (AAE) consensus motif; other site 632772019270 AMP binding site [chemical binding]; other site 632772019271 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772019272 Condensation domain; Region: Condensation; pfam00668 632772019273 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 632772019274 Condensation domain; Region: Condensation; pfam00668 632772019275 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 632772019276 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772019277 acyl-activating enzyme (AAE) consensus motif; other site 632772019278 AMP binding site [chemical binding]; other site 632772019279 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772019280 Condensation domain; Region: Condensation; pfam00668 632772019281 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 632772019282 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772019283 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772019284 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 632772019285 acyl-activating enzyme (AAE) consensus motif; other site 632772019286 AMP binding site [chemical binding]; other site 632772019287 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772019288 Condensation domain; Region: Condensation; pfam00668 632772019289 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 632772019290 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772019291 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772019292 acyl-activating enzyme (AAE) consensus motif; other site 632772019293 AMP binding site [chemical binding]; other site 632772019294 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772019295 Condensation domain; Region: Condensation; pfam00668 632772019296 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 632772019297 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772019298 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772019299 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772019300 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 632772019301 acyl-activating enzyme (AAE) consensus motif; other site 632772019302 AMP binding site [chemical binding]; other site 632772019303 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772019304 Condensation domain; Region: Condensation; pfam00668 632772019305 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 632772019306 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772019307 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772019308 acyl-activating enzyme (AAE) consensus motif; other site 632772019309 AMP binding site [chemical binding]; other site 632772019310 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772019311 peptide synthase; Provisional; Region: PRK12467 632772019312 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772019313 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772019314 acyl-activating enzyme (AAE) consensus motif; other site 632772019315 AMP binding site [chemical binding]; other site 632772019316 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772019317 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772019318 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772019319 acyl-activating enzyme (AAE) consensus motif; other site 632772019320 AMP binding site [chemical binding]; other site 632772019321 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772019322 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 632772019323 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 632772019324 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 632772019325 acyl-activating enzyme (AAE) consensus motif; other site 632772019326 AMP binding site [chemical binding]; other site 632772019327 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772019328 Condensation domain; Region: Condensation; pfam00668 632772019329 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 632772019330 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 632772019331 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632772019332 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 632772019333 Uncharacterized conserved protein [Function unknown]; Region: COG2128 632772019334 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 632772019335 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 632772019336 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 632772019337 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 632772019338 NAD(P) binding pocket [chemical binding]; other site 632772019339 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 632772019340 Glutamine amidotransferase class-I; Region: GATase; pfam00117 632772019341 glutamine binding [chemical binding]; other site 632772019342 catalytic triad [active] 632772019343 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 632772019344 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 632772019345 chorismate binding enzyme; Region: Chorismate_bind; cl10555 632772019346 Chorismate mutase type II; Region: CM_2; cl00693 632772019347 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 632772019348 Lipase (class 2); Region: Lipase_2; pfam01674 632772019349 Transcriptional regulators [Transcription]; Region: GntR; COG1802 632772019350 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772019351 DNA-binding site [nucleotide binding]; DNA binding site 632772019352 FCD domain; Region: FCD; pfam07729 632772019353 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772019354 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772019355 active site 632772019356 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 632772019357 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 632772019358 NAD(P) binding site [chemical binding]; other site 632772019359 catalytic residues [active] 632772019360 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 632772019361 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772019362 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772019363 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772019364 enoyl-CoA hydratase; Provisional; Region: PRK06688 632772019365 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772019366 substrate binding site [chemical binding]; other site 632772019367 oxyanion hole (OAH) forming residues; other site 632772019368 trimer interface [polypeptide binding]; other site 632772019369 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 632772019370 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772019371 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 632772019372 acyl-activating enzyme (AAE) consensus motif; other site 632772019373 acyl-activating enzyme (AAE) consensus motif; other site 632772019374 putative AMP binding site [chemical binding]; other site 632772019375 putative active site [active] 632772019376 putative CoA binding site [chemical binding]; other site 632772019377 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 632772019378 Permease; Region: Permease; pfam02405 632772019379 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 632772019380 Permease; Region: Permease; pfam02405 632772019381 mce related protein; Region: MCE; pfam02470 632772019382 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 632772019383 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 632772019384 mce related protein; Region: MCE; pfam02470 632772019385 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 632772019386 mce related protein; Region: MCE; pfam02470 632772019387 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 632772019388 mce related protein; Region: MCE; pfam02470 632772019389 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 632772019390 mce related protein; Region: MCE; pfam02470 632772019391 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 632772019392 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 632772019393 mce related protein; Region: MCE; pfam02470 632772019394 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 632772019395 ABC-2 type transporter; Region: ABC2_membrane; cl17235 632772019396 ABC-2 type transporter; Region: ABC2_membrane; cl17235 632772019397 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 632772019398 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632772019399 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 632772019400 Walker A/P-loop; other site 632772019401 ATP binding site [chemical binding]; other site 632772019402 Q-loop/lid; other site 632772019403 ABC transporter signature motif; other site 632772019404 Walker B; other site 632772019405 D-loop; other site 632772019406 H-loop/switch region; other site 632772019407 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 632772019408 CoenzymeA binding site [chemical binding]; other site 632772019409 subunit interaction site [polypeptide binding]; other site 632772019410 PHB binding site; other site 632772019411 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 632772019412 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 632772019413 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 632772019414 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 632772019415 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 632772019416 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 632772019417 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 632772019418 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 632772019419 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 632772019420 putative translocon binding site; other site 632772019421 protein-rRNA interface [nucleotide binding]; other site 632772019422 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 632772019423 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 632772019424 G-X-X-G motif; other site 632772019425 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 632772019426 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 632772019427 23S rRNA interface [nucleotide binding]; other site 632772019428 5S rRNA interface [nucleotide binding]; other site 632772019429 putative antibiotic binding site [chemical binding]; other site 632772019430 L25 interface [polypeptide binding]; other site 632772019431 L27 interface [polypeptide binding]; other site 632772019432 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 632772019433 putative translocon interaction site; other site 632772019434 signal recognition particle (SRP54) interaction site; other site 632772019435 L23 interface [polypeptide binding]; other site 632772019436 trigger factor interaction site; other site 632772019437 23S rRNA interface [nucleotide binding]; other site 632772019438 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 632772019439 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 632772019440 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 632772019441 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 632772019442 RNA binding site [nucleotide binding]; other site 632772019443 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 632772019444 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 632772019445 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 632772019446 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 632772019447 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 632772019448 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 632772019449 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 632772019450 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 632772019451 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 632772019452 5S rRNA interface [nucleotide binding]; other site 632772019453 L27 interface [polypeptide binding]; other site 632772019454 23S rRNA interface [nucleotide binding]; other site 632772019455 L5 interface [polypeptide binding]; other site 632772019456 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 632772019457 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 632772019458 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 632772019459 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 632772019460 23S rRNA binding site [nucleotide binding]; other site 632772019461 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 632772019462 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 632772019463 SecY translocase; Region: SecY; pfam00344 632772019464 adenylate kinase; Reviewed; Region: adk; PRK00279 632772019465 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 632772019466 AMP-binding site [chemical binding]; other site 632772019467 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 632772019468 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 632772019469 active site 632772019470 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 632772019471 putative active site [active] 632772019472 dimerization interface [polypeptide binding]; other site 632772019473 putative tRNAtyr binding site [nucleotide binding]; other site 632772019474 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 632772019475 rRNA binding site [nucleotide binding]; other site 632772019476 predicted 30S ribosome binding site; other site 632772019477 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 632772019478 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 632772019479 30S ribosomal protein S13; Region: bact_S13; TIGR03631 632772019480 30S ribosomal protein S11; Validated; Region: PRK05309 632772019481 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 632772019482 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 632772019483 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 632772019484 RNA binding surface [nucleotide binding]; other site 632772019485 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 632772019486 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 632772019487 alphaNTD - beta interaction site [polypeptide binding]; other site 632772019488 alphaNTD homodimer interface [polypeptide binding]; other site 632772019489 alphaNTD - beta' interaction site [polypeptide binding]; other site 632772019490 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 632772019491 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 632772019492 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 632772019493 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 632772019494 dimerization interface 3.5A [polypeptide binding]; other site 632772019495 active site 632772019496 Predicted flavoprotein [General function prediction only]; Region: COG0431 632772019497 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 632772019498 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 632772019499 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919 632772019500 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 632772019501 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 632772019502 active site 632772019503 catalytic residues [active] 632772019504 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 632772019505 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 632772019506 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 632772019507 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 632772019508 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 632772019509 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 632772019510 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 632772019511 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 632772019512 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 632772019513 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 632772019514 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 632772019515 AsnC family; Region: AsnC_trans_reg; pfam01037 632772019516 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 632772019517 Amidinotransferase; Region: Amidinotransf; pfam02274 632772019518 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 632772019519 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 632772019520 inhibitor-cofactor binding pocket; inhibition site 632772019521 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632772019522 catalytic residue [active] 632772019523 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 632772019524 23S rRNA interface [nucleotide binding]; other site 632772019525 L3 interface [polypeptide binding]; other site 632772019526 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 632772019527 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 632772019528 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 632772019529 active site 632772019530 substrate binding site [chemical binding]; other site 632772019531 metal binding site [ion binding]; metal-binding site 632772019532 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 632772019533 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 632772019534 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 632772019535 glutaminase active site [active] 632772019536 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 632772019537 dimer interface [polypeptide binding]; other site 632772019538 active site 632772019539 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 632772019540 dimer interface [polypeptide binding]; other site 632772019541 active site 632772019542 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 632772019543 Uncharacterized conserved protein [Function unknown]; Region: COG0062 632772019544 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 632772019545 putative substrate binding site [chemical binding]; other site 632772019546 putative ATP binding site [chemical binding]; other site 632772019547 alanine racemase; Reviewed; Region: alr; PRK00053 632772019548 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 632772019549 active site 632772019550 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 632772019551 dimer interface [polypeptide binding]; other site 632772019552 substrate binding site [chemical binding]; other site 632772019553 catalytic residues [active] 632772019554 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 632772019555 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 632772019556 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 632772019557 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 632772019558 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 632772019559 Glycoprotease family; Region: Peptidase_M22; pfam00814 632772019560 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 632772019561 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 632772019562 Coenzyme A binding pocket [chemical binding]; other site 632772019563 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 632772019564 UGMP family protein; Validated; Region: PRK09604 632772019565 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 632772019566 nucleotide binding site [chemical binding]; other site 632772019567 Ion channel; Region: Ion_trans_2; pfam07885 632772019568 metallophosphoesterase, PPA1498 family; Region: P_acnes_RR; TIGR03767 632772019569 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 632772019570 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 632772019571 oligomerisation interface [polypeptide binding]; other site 632772019572 mobile loop; other site 632772019573 roof hairpin; other site 632772019574 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 632772019575 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 632772019576 ring oligomerisation interface [polypeptide binding]; other site 632772019577 ATP/Mg binding site [chemical binding]; other site 632772019578 stacking interactions; other site 632772019579 hinge regions; other site 632772019580 Anti-sigma-K factor rskA; Region: RskA; pfam10099 632772019581 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 632772019582 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632772019583 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 632772019584 DNA binding residues [nucleotide binding] 632772019585 Transcription factor WhiB; Region: Whib; pfam02467 632772019586 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 632772019587 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632772019588 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 632772019589 DNA binding residues [nucleotide binding] 632772019590 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 632772019591 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 632772019592 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 632772019593 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 632772019594 active site 632772019595 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 632772019596 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 632772019597 active site 632772019598 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 632772019599 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 632772019600 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 632772019601 GMP synthase; Reviewed; Region: guaA; PRK00074 632772019602 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 632772019603 AMP/PPi binding site [chemical binding]; other site 632772019604 candidate oxyanion hole; other site 632772019605 catalytic triad [active] 632772019606 potential glutamine specificity residues [chemical binding]; other site 632772019607 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 632772019608 ATP Binding subdomain [chemical binding]; other site 632772019609 Ligand Binding sites [chemical binding]; other site 632772019610 Dimerization subdomain; other site 632772019611 PspC domain; Region: PspC; pfam04024 632772019612 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 632772019613 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 632772019614 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632772019615 ATP binding site [chemical binding]; other site 632772019616 Mg2+ binding site [ion binding]; other site 632772019617 G-X-G motif; other site 632772019618 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632772019619 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632772019620 active site 632772019621 phosphorylation site [posttranslational modification] 632772019622 intermolecular recognition site; other site 632772019623 dimerization interface [polypeptide binding]; other site 632772019624 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632772019625 DNA binding residues [nucleotide binding] 632772019626 dimerization interface [polypeptide binding]; other site 632772019627 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 632772019628 Catalytic domain of Protein Kinases; Region: PKc; cd00180 632772019629 active site 632772019630 ATP binding site [chemical binding]; other site 632772019631 substrate binding site [chemical binding]; other site 632772019632 activation loop (A-loop); other site 632772019633 DNA Polymerase Y-family; Region: PolY_like; cd03468 632772019634 active site 632772019635 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 632772019636 DNA binding site [nucleotide binding] 632772019637 ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351 632772019638 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 632772019639 metal binding site [ion binding]; metal-binding site 632772019640 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 632772019641 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 632772019642 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 632772019643 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 632772019644 nucleophilic elbow; other site 632772019645 catalytic site [active] 632772019646 catalytic triad; other site 632772019647 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 632772019648 active site 632772019649 diiron metal binding site [ion binding]; other site 632772019650 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 632772019651 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 632772019652 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 632772019653 putative dimer interface [polypeptide binding]; other site 632772019654 putative [2Fe-2S] cluster binding site [ion binding]; other site 632772019655 short chain dehydrogenase; Provisional; Region: PRK07201 632772019656 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 632772019657 putative NAD(P) binding site [chemical binding]; other site 632772019658 active site 632772019659 putative substrate binding site [chemical binding]; other site 632772019660 classical (c) SDRs; Region: SDR_c; cd05233 632772019661 NAD(P) binding site [chemical binding]; other site 632772019662 active site 632772019663 MMPL family; Region: MMPL; pfam03176 632772019664 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 632772019665 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 632772019666 intersubunit interface [polypeptide binding]; other site 632772019667 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 632772019668 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 632772019669 dimer interface [polypeptide binding]; other site 632772019670 putative PBP binding regions; other site 632772019671 ABC-ATPase subunit interface; other site 632772019672 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 632772019673 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 632772019674 Walker A/P-loop; other site 632772019675 ATP binding site [chemical binding]; other site 632772019676 Q-loop/lid; other site 632772019677 ABC transporter signature motif; other site 632772019678 Walker B; other site 632772019679 D-loop; other site 632772019680 H-loop/switch region; other site 632772019681 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 632772019682 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 632772019683 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 632772019684 active site 632772019685 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 632772019686 generic binding surface II; other site 632772019687 generic binding surface I; other site 632772019688 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 632772019689 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 632772019690 active site residue [active] 632772019691 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 632772019692 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 632772019693 gating phenylalanine in ion channel; other site 632772019694 Transcriptional regulator [Transcription]; Region: LysR; COG0583 632772019695 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 632772019696 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 632772019697 putative dimerization interface [polypeptide binding]; other site 632772019698 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 632772019699 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 632772019700 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 632772019701 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 632772019702 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 632772019703 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 632772019704 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 632772019705 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 632772019706 homodimer interface [polypeptide binding]; other site 632772019707 NADP binding site [chemical binding]; other site 632772019708 substrate binding site [chemical binding]; other site 632772019709 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 632772019710 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 632772019711 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 632772019712 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 632772019713 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 632772019714 homodimer interface [polypeptide binding]; other site 632772019715 substrate-cofactor binding pocket; other site 632772019716 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632772019717 catalytic residue [active] 632772019718 isocitrate dehydrogenase; Validated; Region: PRK08299 632772019719 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 632772019720 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772019721 putative substrate translocation pore; other site 632772019722 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 632772019723 putative active site [active] 632772019724 putative catalytic site [active] 632772019725 putative DNA binding site [nucleotide binding]; other site 632772019726 putative phosphate binding site [ion binding]; other site 632772019727 metal binding site A [ion binding]; metal-binding site 632772019728 putative AP binding site [nucleotide binding]; other site 632772019729 putative metal binding site B [ion binding]; other site 632772019730 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 632772019731 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 632772019732 active site 632772019733 HIGH motif; other site 632772019734 dimer interface [polypeptide binding]; other site 632772019735 KMSKS motif; other site 632772019736 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 632772019737 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 632772019738 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 632772019739 malate dehydrogenase; Provisional; Region: PRK05442 632772019740 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 632772019741 NAD(P) binding site [chemical binding]; other site 632772019742 dimer interface [polypeptide binding]; other site 632772019743 malate binding site [chemical binding]; other site 632772019744 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 632772019745 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 632772019746 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 632772019747 L-aspartate oxidase; Provisional; Region: PRK06175 632772019748 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 632772019749 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 632772019750 putative Iron-sulfur protein interface [polypeptide binding]; other site 632772019751 putative proximal heme binding site [chemical binding]; other site 632772019752 putative SdhC-like subunit interface [polypeptide binding]; other site 632772019753 putative distal heme binding site [chemical binding]; other site 632772019754 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 632772019755 putative Iron-sulfur protein interface [polypeptide binding]; other site 632772019756 putative proximal heme binding site [chemical binding]; other site 632772019757 putative SdhD-like interface [polypeptide binding]; other site 632772019758 putative distal heme binding site [chemical binding]; other site 632772019759 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 632772019760 active site 632772019761 catalytic motif [active] 632772019762 Zn binding site [ion binding]; other site 632772019763 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 632772019764 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 632772019765 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 632772019766 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 632772019767 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 632772019768 adenosine deaminase; Provisional; Region: PRK09358 632772019769 active site 632772019770 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 632772019771 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 632772019772 NlpC/P60 family; Region: NLPC_P60; pfam00877 632772019773 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 632772019774 active site 632772019775 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 632772019776 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 632772019777 active site 632772019778 substrate binding site [chemical binding]; other site 632772019779 metal binding site [ion binding]; metal-binding site 632772019780 purine nucleoside phosphorylase; Provisional; Region: PRK08202 632772019781 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 632772019782 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772019783 substrate binding site [chemical binding]; other site 632772019784 oxyanion hole (OAH) forming residues; other site 632772019785 trimer interface [polypeptide binding]; other site 632772019786 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 632772019787 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 632772019788 metal binding site [ion binding]; metal-binding site 632772019789 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 632772019790 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 632772019791 metal binding site [ion binding]; metal-binding site 632772019792 putative dimer interface [polypeptide binding]; other site 632772019793 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 632772019794 putative active site pocket [active] 632772019795 dimerization interface [polypeptide binding]; other site 632772019796 putative catalytic residue [active] 632772019797 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 632772019798 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 632772019799 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 632772019800 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 632772019801 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 632772019802 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 632772019803 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632772019804 homodimer interface [polypeptide binding]; other site 632772019805 catalytic residue [active] 632772019806 glycerol kinase; Provisional; Region: glpK; PRK00047 632772019807 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 632772019808 N- and C-terminal domain interface [polypeptide binding]; other site 632772019809 active site 632772019810 MgATP binding site [chemical binding]; other site 632772019811 catalytic site [active] 632772019812 metal binding site [ion binding]; metal-binding site 632772019813 putative homotetramer interface [polypeptide binding]; other site 632772019814 glycerol binding site [chemical binding]; other site 632772019815 homodimer interface [polypeptide binding]; other site 632772019816 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 632772019817 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 632772019818 Protein of unknown function (DUF1353); Region: DUF1353; pfam07087 632772019819 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 632772019820 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 632772019821 putative DNA binding site [nucleotide binding]; other site 632772019822 catalytic residue [active] 632772019823 putative H2TH interface [polypeptide binding]; other site 632772019824 putative catalytic residues [active] 632772019825 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 632772019826 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 632772019827 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 632772019828 ATP binding site [chemical binding]; other site 632772019829 putative Mg++ binding site [ion binding]; other site 632772019830 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 632772019831 nucleotide binding region [chemical binding]; other site 632772019832 ATP-binding site [chemical binding]; other site 632772019833 DEAD/H associated; Region: DEAD_assoc; pfam08494 632772019834 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 632772019835 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 632772019836 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 632772019837 active site 632772019838 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772019839 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772019840 active site 632772019841 aldehyde dehydrogenase family 7 member; Region: PLN02315 632772019842 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 632772019843 tetrameric interface [polypeptide binding]; other site 632772019844 NAD binding site [chemical binding]; other site 632772019845 catalytic residues [active] 632772019846 Domain of unknown function (DUF1338); Region: DUF1338; cl02226 632772019847 Domain of unknown function (DUF1338); Region: DUF1338; cl02226 632772019848 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 632772019849 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 632772019850 AsnC family; Region: AsnC_trans_reg; pfam01037 632772019851 L-lysine aminotransferase; Provisional; Region: PRK08297 632772019852 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 632772019853 inhibitor-cofactor binding pocket; inhibition site 632772019854 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632772019855 catalytic residue [active] 632772019856 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 632772019857 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 632772019858 VanZ like family; Region: VanZ; cl01971 632772019859 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 632772019860 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 632772019861 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 632772019862 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 632772019863 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 632772019864 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 632772019865 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 632772019866 carboxyltransferase (CT) interaction site; other site 632772019867 biotinylation site [posttranslational modification]; other site 632772019868 Condensation domain; Region: Condensation; pfam00668 632772019869 Fe-S metabolism associated domain; Region: SufE; cl00951 632772019870 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 632772019871 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 632772019872 active site residue [active] 632772019873 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 632772019874 active site residue [active] 632772019875 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 632772019876 heme-binding site [chemical binding]; other site 632772019877 Condensation domain; Region: Condensation; pfam00668 632772019878 peptide synthase; Provisional; Region: PRK12316 632772019879 potential frameshift: common BLAST hit: gi|111023252|ref|YP_706224.1| multidrug ABC transporter 632772019880 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 632772019881 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 632772019882 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772019883 Maf-like protein; Region: Maf; pfam02545 632772019884 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 632772019885 active site 632772019886 dimer interface [polypeptide binding]; other site 632772019887 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 632772019888 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 632772019889 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 632772019890 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 632772019891 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 632772019892 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 632772019893 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 632772019894 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 632772019895 Bacterial PH domain; Region: DUF304; pfam03703 632772019896 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 632772019897 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632772019898 active site 632772019899 phosphorylation site [posttranslational modification] 632772019900 intermolecular recognition site; other site 632772019901 dimerization interface [polypeptide binding]; other site 632772019902 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 632772019903 DNA binding site [nucleotide binding] 632772019904 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 632772019905 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 632772019906 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 632772019907 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632772019908 ATP binding site [chemical binding]; other site 632772019909 Mg2+ binding site [ion binding]; other site 632772019910 G-X-G motif; other site 632772019911 Predicted membrane protein [Function unknown]; Region: COG2246 632772019912 GtrA-like protein; Region: GtrA; pfam04138 632772019913 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 632772019914 ATP-grasp domain; Region: ATP-grasp; pfam02222 632772019915 AIR carboxylase; Region: AIRC; pfam00731 632772019916 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 632772019917 putative active site [active] 632772019918 TIGR03089 family protein; Region: TIGR03089 632772019919 Transcriptional regulator [Transcription]; Region: LytR; COG1316 632772019920 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 632772019921 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 632772019922 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 632772019923 NADP binding site [chemical binding]; other site 632772019924 active site 632772019925 putative substrate binding site [chemical binding]; other site 632772019926 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 632772019927 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 632772019928 Probable Catalytic site; other site 632772019929 metal-binding site 632772019930 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 632772019931 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 632772019932 active site 632772019933 Substrate binding site; other site 632772019934 Mg++ binding site; other site 632772019935 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 632772019936 N-terminal domain interface [polypeptide binding]; other site 632772019937 sulfate 1 binding site; other site 632772019938 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 632772019939 nudix motif; other site 632772019940 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 632772019941 F420-0:gamma-glutamyl ligase; Region: F420_cofE; TIGR01916 632772019942 F420 biosynthesis protein FbiB, C-terminal domain; Region: F420_FbiB_CTERM; TIGR03553 632772019943 FMN binding site [chemical binding]; other site 632772019944 dimer interface [polypeptide binding]; other site 632772019945 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 632772019946 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 632772019947 phosphate binding site [ion binding]; other site 632772019948 dimer interface [polypeptide binding]; other site 632772019949 substrate binding site [chemical binding]; other site 632772019950 Transcription factor WhiB; Region: Whib; pfam02467 632772019951 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 632772019952 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 632772019953 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 632772019954 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 632772019955 active site 632772019956 substrate binding site [chemical binding]; other site 632772019957 metal binding site [ion binding]; metal-binding site 632772019958 bifunctional phosphoglucose/phosphomannose isomerase; Validated; Region: PRK08674 632772019959 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 632772019960 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 632772019961 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 632772019962 amino acid transporter; Region: 2A0306; TIGR00909 632772019963 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 632772019964 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772019965 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772019966 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 632772019967 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 632772019968 homotetramer interface [polypeptide binding]; other site 632772019969 ligand binding site [chemical binding]; other site 632772019970 catalytic site [active] 632772019971 NAD binding site [chemical binding]; other site 632772019972 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 632772019973 Thymidylate kinase; Region: Thymidylate_kin; pfam02223 632772019974 TMP-binding site; other site 632772019975 ATP-binding site [chemical binding]; other site 632772019976 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 632772019977 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632772019978 active site 632772019979 phosphorylation site [posttranslational modification] 632772019980 intermolecular recognition site; other site 632772019981 dimerization interface [polypeptide binding]; other site 632772019982 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 632772019983 DNA binding site [nucleotide binding] 632772019984 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 632772019985 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 632772019986 dimerization interface [polypeptide binding]; other site 632772019987 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 632772019988 dimer interface [polypeptide binding]; other site 632772019989 phosphorylation site [posttranslational modification] 632772019990 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632772019991 ATP binding site [chemical binding]; other site 632772019992 Mg2+ binding site [ion binding]; other site 632772019993 G-X-G motif; other site 632772019994 lipoprotein LpqB; Provisional; Region: PRK13616 632772019995 Sporulation and spore germination; Region: Germane; pfam10646 632772019996 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 632772019997 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 632772019998 30S subunit binding site; other site 632772019999 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 632772020000 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 632772020001 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 632772020002 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632772020003 active site 632772020004 motif I; other site 632772020005 motif II; other site 632772020006 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 632772020007 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 632772020008 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 632772020009 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 632772020010 FAD binding pocket [chemical binding]; other site 632772020011 FAD binding motif [chemical binding]; other site 632772020012 phosphate binding motif [ion binding]; other site 632772020013 beta-alpha-beta structure motif; other site 632772020014 NAD binding pocket [chemical binding]; other site 632772020015 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 632772020016 catalytic loop [active] 632772020017 iron binding site [ion binding]; other site 632772020018 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 632772020019 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 632772020020 putative di-iron ligands [ion binding]; other site 632772020021 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 632772020022 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 632772020023 putative di-iron ligands [ion binding]; other site 632772020024 Predicted GTPases [General function prediction only]; Region: COG1162 632772020025 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 632772020026 GTPase/Zn-binding domain interface [polypeptide binding]; other site 632772020027 GTP/Mg2+ binding site [chemical binding]; other site 632772020028 G4 box; other site 632772020029 G5 box; other site 632772020030 G1 box; other site 632772020031 Switch I region; other site 632772020032 G2 box; other site 632772020033 G3 box; other site 632772020034 Switch II region; other site 632772020035 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 632772020036 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 632772020037 hinge; other site 632772020038 active site 632772020039 Uncharacterized conserved protein [Function unknown]; Region: COG2135 632772020040 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 632772020041 putative deacylase active site [active] 632772020042 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 632772020043 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632772020044 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 632772020045 DNA binding residues [nucleotide binding] 632772020046 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 632772020047 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 632772020048 carboxyltransferase (CT) interaction site; other site 632772020049 biotinylation site [posttranslational modification]; other site 632772020050 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 632772020051 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 632772020052 Histidine kinase; Region: HisKA_2; pfam07568 632772020053 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632772020054 ATP binding site [chemical binding]; other site 632772020055 Mg2+ binding site [ion binding]; other site 632772020056 G-X-G motif; other site 632772020057 Transcription factor WhiB; Region: Whib; pfam02467 632772020058 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 632772020059 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 632772020060 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 632772020061 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 632772020062 Coenzyme A binding pocket [chemical binding]; other site 632772020063 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 632772020064 catalytic core [active] 632772020065 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 632772020066 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 632772020067 P-loop; other site 632772020068 Magnesium ion binding site [ion binding]; other site 632772020069 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 632772020070 Magnesium ion binding site [ion binding]; other site 632772020071 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772020072 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 632772020073 NAD(P) binding site [chemical binding]; other site 632772020074 active site 632772020075 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 632772020076 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 632772020077 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 632772020078 conserved cys residue [active] 632772020079 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632772020080 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 632772020081 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 632772020082 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 632772020083 active site 632772020084 helicase 45; Provisional; Region: PTZ00424 632772020085 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 632772020086 ATP binding site [chemical binding]; other site 632772020087 Mg++ binding site [ion binding]; other site 632772020088 motif III; other site 632772020089 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 632772020090 nucleotide binding region [chemical binding]; other site 632772020091 ATP-binding site [chemical binding]; other site 632772020092 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 632772020093 dinuclear metal binding motif [ion binding]; other site 632772020094 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 632772020095 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772020096 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772020097 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 632772020098 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 632772020099 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 632772020100 ATP binding site [chemical binding]; other site 632772020101 substrate interface [chemical binding]; other site 632772020102 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 632772020103 active site residue [active] 632772020104 TIGR02569 family protein; Region: TIGR02569_actnb 632772020105 Transcriptional regulators [Transcription]; Region: FadR; COG2186 632772020106 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772020107 DNA-binding site [nucleotide binding]; DNA binding site 632772020108 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 632772020109 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 632772020110 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772020111 putative substrate translocation pore; other site 632772020112 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 632772020113 nitrite reductase subunit NirD; Provisional; Region: PRK14989 632772020114 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 632772020115 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 632772020116 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 632772020117 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 632772020118 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 632772020119 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 632772020120 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 632772020121 active site 632772020122 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 632772020123 DNA binding site [nucleotide binding] 632772020124 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 632772020125 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 632772020126 putative active site [active] 632772020127 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 632772020128 putative active site [active] 632772020129 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 632772020130 GTP binding site; other site 632772020131 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 632772020132 MPT binding site; other site 632772020133 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772020134 DNA-binding site [nucleotide binding]; DNA binding site 632772020135 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 632772020136 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 632772020137 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632772020138 homodimer interface [polypeptide binding]; other site 632772020139 catalytic residue [active] 632772020140 Secretory lipase; Region: LIP; pfam03583 632772020141 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 632772020142 active site 632772020143 DNA binding site [nucleotide binding] 632772020144 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 632772020145 Serine hydrolase; Region: Ser_hydrolase; cl17834 632772020146 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 632772020147 Part of AAA domain; Region: AAA_19; pfam13245 632772020148 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 632772020149 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 632772020150 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 632772020151 Part of AAA domain; Region: AAA_19; pfam13245 632772020152 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 632772020153 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 632772020154 Predicted membrane protein [Function unknown]; Region: COG4270 632772020155 Ion channel; Region: Ion_trans_2; pfam07885 632772020156 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 632772020157 TrkA-N domain; Region: TrkA_N; pfam02254 632772020158 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 632772020159 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 632772020160 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 632772020161 putative NADH binding site [chemical binding]; other site 632772020162 putative active site [active] 632772020163 nudix motif; other site 632772020164 putative metal binding site [ion binding]; other site 632772020165 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 632772020166 catalytic residues [active] 632772020167 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 632772020168 Family description; Region: UvrD_C_2; pfam13538 632772020169 HRDC domain; Region: HRDC; pfam00570 632772020170 Transcription factor WhiB; Region: Whib; pfam02467 632772020171 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 632772020172 ABC1 family; Region: ABC1; pfam03109 632772020173 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 632772020174 active site 632772020175 ATP binding site [chemical binding]; other site 632772020176 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 632772020177 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 632772020178 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 632772020179 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 632772020180 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 632772020181 hypothetical protein; Provisional; Region: PRK12438 632772020182 hypothetical protein; Validated; Region: PRK00068 632772020183 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 632772020184 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 632772020185 acyl-CoA synthetase; Validated; Region: PRK07788 632772020186 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772020187 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772020188 acyl-activating enzyme (AAE) consensus motif; other site 632772020189 AMP binding site [chemical binding]; other site 632772020190 active site 632772020191 CoA binding site [chemical binding]; other site 632772020192 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772020193 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772020194 active site 632772020195 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772020196 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772020197 active site 632772020198 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 632772020199 Histidine kinase; Region: HisKA_3; pfam07730 632772020200 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632772020201 ATP binding site [chemical binding]; other site 632772020202 Mg2+ binding site [ion binding]; other site 632772020203 G-X-G motif; other site 632772020204 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632772020205 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632772020206 active site 632772020207 phosphorylation site [posttranslational modification] 632772020208 intermolecular recognition site; other site 632772020209 dimerization interface [polypeptide binding]; other site 632772020210 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632772020211 DNA binding residues [nucleotide binding] 632772020212 dimerization interface [polypeptide binding]; other site 632772020213 multicopper oxidase; Provisional; Region: PRK10965 632772020214 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 632772020215 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 632772020216 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 632772020217 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 632772020218 active site 632772020219 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 632772020220 active site clefts [active] 632772020221 zinc binding site [ion binding]; other site 632772020222 dimer interface [polypeptide binding]; other site 632772020223 peptide chain release factor 2; Validated; Region: prfB; PRK00578 632772020224 This domain is found in peptide chain release factors; Region: PCRF; smart00937 632772020225 RF-1 domain; Region: RF-1; pfam00472 632772020226 Mechanosensitive ion channel; Region: MS_channel; pfam00924 632772020227 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 632772020228 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 632772020229 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632772020230 Walker A/P-loop; other site 632772020231 ATP binding site [chemical binding]; other site 632772020232 Q-loop/lid; other site 632772020233 ABC transporter signature motif; other site 632772020234 Walker B; other site 632772020235 D-loop; other site 632772020236 H-loop/switch region; other site 632772020237 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 632772020238 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 632772020239 SmpB-tmRNA interface; other site 632772020240 CrcB-like protein; Region: CRCB; cl09114 632772020241 camphor resistance protein CrcB; Provisional; Region: PRK14211 632772020242 phosphoglucomutase; Validated; Region: PRK07564 632772020243 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 632772020244 active site 632772020245 substrate binding site [chemical binding]; other site 632772020246 metal binding site [ion binding]; metal-binding site 632772020247 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772020248 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632772020249 putative substrate translocation pore; other site 632772020250 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 632772020251 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 632772020252 catalytic residues [active] 632772020253 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 632772020254 PAS domain; Region: PAS_9; pfam13426 632772020255 putative active site [active] 632772020256 heme pocket [chemical binding]; other site 632772020257 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 632772020258 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 632772020259 trimer interface [polypeptide binding]; other site 632772020260 active site 632772020261 substrate binding site [chemical binding]; other site 632772020262 CoA binding site [chemical binding]; other site 632772020263 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 632772020264 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 632772020265 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 632772020266 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 632772020267 putative FMN binding site [chemical binding]; other site 632772020268 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 632772020269 DEAD-like helicases superfamily; Region: DEXDc; smart00487 632772020270 ATP binding site [chemical binding]; other site 632772020271 Mg++ binding site [ion binding]; other site 632772020272 motif III; other site 632772020273 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 632772020274 nucleotide binding region [chemical binding]; other site 632772020275 ATP-binding site [chemical binding]; other site 632772020276 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 632772020277 MoaE homodimer interface [polypeptide binding]; other site 632772020278 MoaD interaction [polypeptide binding]; other site 632772020279 active site residues [active] 632772020280 molybdenum cofactor biosynthesis protein MoaC; Provisional; Region: moaC; PRK09364 632772020281 bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional; Region: moaC; PRK03604 632772020282 trimer interface [polypeptide binding]; other site 632772020283 dimer interface [polypeptide binding]; other site 632772020284 putative active site [active] 632772020285 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 632772020286 MPT binding site; other site 632772020287 trimer interface [polypeptide binding]; other site 632772020288 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 632772020289 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 632772020290 dimer interface [polypeptide binding]; other site 632772020291 putative functional site; other site 632772020292 putative MPT binding site; other site 632772020293 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 632772020294 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632772020295 FeS/SAM binding site; other site 632772020296 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 632772020297 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 632772020298 MoaE interaction surface [polypeptide binding]; other site 632772020299 MoeB interaction surface [polypeptide binding]; other site 632772020300 thiocarboxylated glycine; other site 632772020301 NADH(P)-binding; Region: NAD_binding_10; pfam13460 632772020302 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772020303 NAD(P) binding site [chemical binding]; other site 632772020304 active site 632772020305 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 632772020306 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 632772020307 homodimer interface [polypeptide binding]; other site 632772020308 NAD binding pocket [chemical binding]; other site 632772020309 ATP binding pocket [chemical binding]; other site 632772020310 Mg binding site [ion binding]; other site 632772020311 active-site loop [active] 632772020312 nucleosidase; Provisional; Region: PRK05634 632772020313 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 632772020314 META domain; Region: META; pfam03724 632772020315 META domain; Region: META; pfam03724 632772020316 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772020317 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772020318 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 632772020319 Predicted flavoprotein [General function prediction only]; Region: COG0431 632772020320 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 632772020321 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 632772020322 FAD binding pocket [chemical binding]; other site 632772020323 FAD binding motif [chemical binding]; other site 632772020324 phosphate binding motif [ion binding]; other site 632772020325 NAD binding pocket [chemical binding]; other site 632772020326 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 632772020327 catalytic residues [active] 632772020328 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 632772020329 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 632772020330 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 632772020331 Class I ribonucleotide reductase; Region: RNR_I; cd01679 632772020332 active site 632772020333 dimer interface [polypeptide binding]; other site 632772020334 catalytic residues [active] 632772020335 effector binding site; other site 632772020336 R2 peptide binding site; other site 632772020337 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 632772020338 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 632772020339 dimer interface [polypeptide binding]; other site 632772020340 putative radical transfer pathway; other site 632772020341 diiron center [ion binding]; other site 632772020342 tyrosyl radical; other site 632772020343 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 632772020344 nudix motif; other site 632772020345 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 632772020346 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 632772020347 siderophore binding site; other site 632772020348 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 632772020349 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 632772020350 siderophore binding site; other site 632772020351 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 632772020352 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 632772020353 D-pathway; other site 632772020354 Putative ubiquinol binding site [chemical binding]; other site 632772020355 Low-spin heme (heme b) binding site [chemical binding]; other site 632772020356 Putative water exit pathway; other site 632772020357 Binuclear center (heme o3/CuB) [ion binding]; other site 632772020358 K-pathway; other site 632772020359 Putative proton exit pathway; other site 632772020360 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 632772020361 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 632772020362 phosphoserine phosphatase SerB; Region: serB; TIGR00338 632772020363 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 632772020364 motif II; other site 632772020365 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 632772020366 dimer interface [polypeptide binding]; other site 632772020367 putative active site [active] 632772020368 Predicted membrane protein [Function unknown]; Region: COG2364 632772020369 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 632772020370 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 632772020371 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 632772020372 active site 632772020373 catalytic site [active] 632772020374 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 632772020375 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632772020376 Walker A/P-loop; other site 632772020377 ATP binding site [chemical binding]; other site 632772020378 Q-loop/lid; other site 632772020379 ABC transporter signature motif; other site 632772020380 Walker B; other site 632772020381 D-loop; other site 632772020382 H-loop/switch region; other site 632772020383 enoyl-CoA hydratase; Provisional; Region: PRK05862 632772020384 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772020385 substrate binding site [chemical binding]; other site 632772020386 oxyanion hole (OAH) forming residues; other site 632772020387 trimer interface [polypeptide binding]; other site 632772020388 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772020389 S-adenosylmethionine binding site [chemical binding]; other site 632772020390 PQQ-like domain; Region: PQQ_2; pfam13360 632772020391 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 632772020392 Trp docking motif [polypeptide binding]; other site 632772020393 active site 632772020394 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 632772020395 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 632772020396 trimer interface [polypeptide binding]; other site 632772020397 active site 632772020398 substrate binding site [chemical binding]; other site 632772020399 CoA binding site [chemical binding]; other site 632772020400 Protein of unknown function (DUF3253); Region: DUF3253; pfam11625 632772020401 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 632772020402 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 632772020403 Uncharacterized conserved protein [Function unknown]; Region: COG1543 632772020404 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 632772020405 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 632772020406 Methyltransferase domain; Region: Methyltransf_31; pfam13847 632772020407 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772020408 S-adenosylmethionine binding site [chemical binding]; other site 632772020409 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 632772020410 Ligand binding site [chemical binding]; other site 632772020411 Electron transfer flavoprotein domain; Region: ETF; pfam01012 632772020412 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 632772020413 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 632772020414 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 632772020415 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 632772020416 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 632772020417 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 632772020418 putative acyl-acceptor binding pocket; other site 632772020419 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 632772020420 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 632772020421 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 632772020422 catalytic residue [active] 632772020423 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 632772020424 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 632772020425 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 632772020426 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 632772020427 nucleotide binding pocket [chemical binding]; other site 632772020428 K-X-D-G motif; other site 632772020429 catalytic site [active] 632772020430 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 632772020431 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 632772020432 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 632772020433 Dimer interface [polypeptide binding]; other site 632772020434 BRCT sequence motif; other site 632772020435 putative acetyltransferase; Provisional; Region: PRK03624 632772020436 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 632772020437 Coenzyme A binding pocket [chemical binding]; other site 632772020438 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 632772020439 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 632772020440 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 632772020441 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 632772020442 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 632772020443 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 632772020444 Histidine kinase; Region: HisKA_3; pfam07730 632772020445 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 632772020446 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632772020447 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632772020448 active site 632772020449 phosphorylation site [posttranslational modification] 632772020450 intermolecular recognition site; other site 632772020451 dimerization interface [polypeptide binding]; other site 632772020452 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632772020453 DNA binding residues [nucleotide binding] 632772020454 dimerization interface [polypeptide binding]; other site 632772020455 6-phosphofructokinase; Provisional; Region: PRK03202 632772020456 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 632772020457 active site 632772020458 ADP/pyrophosphate binding site [chemical binding]; other site 632772020459 dimerization interface [polypeptide binding]; other site 632772020460 allosteric effector site; other site 632772020461 fructose-1,6-bisphosphate binding site; other site 632772020462 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 632772020463 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 632772020464 GatB domain; Region: GatB_Yqey; smart00845 632772020465 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 632772020466 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 632772020467 Predicted membrane protein [Function unknown]; Region: COG2259 632772020468 amino acid transporter; Region: 2A0306; TIGR00909 632772020469 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 632772020470 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 632772020471 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 632772020472 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 632772020473 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 632772020474 PYR/PP interface [polypeptide binding]; other site 632772020475 dimer interface [polypeptide binding]; other site 632772020476 TPP binding site [chemical binding]; other site 632772020477 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 632772020478 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 632772020479 TPP-binding site [chemical binding]; other site 632772020480 dimer interface [polypeptide binding]; other site 632772020481 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 632772020482 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 632772020483 putative valine binding site [chemical binding]; other site 632772020484 dimer interface [polypeptide binding]; other site 632772020485 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 632772020486 ketol-acid reductoisomerase; Provisional; Region: PRK05479 632772020487 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 632772020488 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 632772020489 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 632772020490 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 632772020491 ligand binding site [chemical binding]; other site 632772020492 NAD binding site [chemical binding]; other site 632772020493 dimerization interface [polypeptide binding]; other site 632772020494 catalytic site [active] 632772020495 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 632772020496 putative L-serine binding site [chemical binding]; other site 632772020497 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 632772020498 tartrate dehydrogenase; Region: TTC; TIGR02089 632772020499 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772020500 putative substrate translocation pore; other site 632772020501 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632772020502 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 632772020503 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 632772020504 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 632772020505 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 632772020506 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 632772020507 HIGH motif; other site 632772020508 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 632772020509 active site 632772020510 KMSKS motif; other site 632772020511 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 632772020512 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 632772020513 Transcriptional regulator [Transcription]; Region: IclR; COG1414 632772020514 Bacterial transcriptional regulator; Region: IclR; pfam01614 632772020515 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 632772020516 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 632772020517 substrate binding site [chemical binding]; other site 632772020518 ligand binding site [chemical binding]; other site 632772020519 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 632772020520 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 632772020521 substrate binding site [chemical binding]; other site 632772020522 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 632772020523 IHF - DNA interface [nucleotide binding]; other site 632772020524 IHF dimer interface [polypeptide binding]; other site 632772020525 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 632772020526 active site 632772020527 Ap6A binding site [chemical binding]; other site 632772020528 nudix motif; other site 632772020529 metal binding site [ion binding]; metal-binding site 632772020530 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 632772020531 catalytic core [active] 632772020532 polyphosphate kinase; Provisional; Region: PRK05443 632772020533 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 632772020534 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 632772020535 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 632772020536 putative domain interface [polypeptide binding]; other site 632772020537 putative active site [active] 632772020538 catalytic site [active] 632772020539 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 632772020540 putative active site [active] 632772020541 catalytic site [active] 632772020542 Guanylyl transferase CofC like; Region: CofC; cl17472 632772020543 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 632772020544 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 632772020545 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 632772020546 cystathionine gamma-lyase; Validated; Region: PRK07582 632772020547 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 632772020548 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 632772020549 catalytic residue [active] 632772020550 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 632772020551 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 632772020552 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 632772020553 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 632772020554 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 632772020555 thiamine monophosphate kinase; Provisional; Region: PRK05731 632772020556 ATP binding site [chemical binding]; other site 632772020557 dimerization interface [polypeptide binding]; other site 632772020558 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 632772020559 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 632772020560 trimer interface [polypeptide binding]; other site 632772020561 putative metal binding site [ion binding]; other site 632772020562 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 632772020563 ligand binding site [chemical binding]; other site 632772020564 active site 632772020565 UGI interface [polypeptide binding]; other site 632772020566 catalytic site [active] 632772020567 enoyl-CoA hydratase; Provisional; Region: PRK06688 632772020568 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772020569 substrate binding site [chemical binding]; other site 632772020570 oxyanion hole (OAH) forming residues; other site 632772020571 trimer interface [polypeptide binding]; other site 632772020572 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 632772020573 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 632772020574 DAK2 domain; Region: Dak2; pfam02734 632772020575 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 632772020576 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 632772020577 generic binding surface II; other site 632772020578 ssDNA binding site; other site 632772020579 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 632772020580 ATP binding site [chemical binding]; other site 632772020581 putative Mg++ binding site [ion binding]; other site 632772020582 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 632772020583 nucleotide binding region [chemical binding]; other site 632772020584 ATP-binding site [chemical binding]; other site 632772020585 pyruvate carboxylase; Reviewed; Region: PRK12999 632772020586 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 632772020587 ATP-grasp domain; Region: ATP-grasp_4; cl17255 632772020588 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 632772020589 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 632772020590 active site 632772020591 catalytic residues [active] 632772020592 metal binding site [ion binding]; metal-binding site 632772020593 homodimer binding site [polypeptide binding]; other site 632772020594 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 632772020595 carboxyltransferase (CT) interaction site; other site 632772020596 biotinylation site [posttranslational modification]; other site 632772020597 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 632772020598 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772020599 S-adenosylmethionine binding site [chemical binding]; other site 632772020600 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 632772020601 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 632772020602 active site 632772020603 (T/H)XGH motif; other site 632772020604 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 632772020605 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 632772020606 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 632772020607 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 632772020608 ribonuclease III; Reviewed; Region: rnc; PRK00102 632772020609 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 632772020610 dimerization interface [polypeptide binding]; other site 632772020611 active site 632772020612 metal binding site [ion binding]; metal-binding site 632772020613 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 632772020614 dsRNA binding site [nucleotide binding]; other site 632772020615 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 632772020616 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 632772020617 DNA binding site [nucleotide binding] 632772020618 catalytic residue [active] 632772020619 H2TH interface [polypeptide binding]; other site 632772020620 putative catalytic residues [active] 632772020621 turnover-facilitating residue; other site 632772020622 intercalation triad [nucleotide binding]; other site 632772020623 8OG recognition residue [nucleotide binding]; other site 632772020624 putative reading head residues; other site 632772020625 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 632772020626 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 632772020627 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 632772020628 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 632772020629 acylphosphatase; Provisional; Region: PRK14422 632772020630 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 632772020631 AAA domain; Region: AAA_23; pfam13476 632772020632 Walker A/P-loop; other site 632772020633 ATP binding site [chemical binding]; other site 632772020634 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 632772020635 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 632772020636 ABC transporter signature motif; other site 632772020637 Walker B; other site 632772020638 D-loop; other site 632772020639 H-loop/switch region; other site 632772020640 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 632772020641 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 632772020642 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 632772020643 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 632772020644 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 632772020645 Nitrogen regulatory protein P-II; Region: P-II; smart00938 632772020646 PII uridylyl-transferase; Provisional; Region: PRK03381 632772020647 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 632772020648 metal binding triad; other site 632772020649 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 632772020650 HD domain; Region: HD; pfam01966 632772020651 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 632772020652 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 632772020653 signal recognition particle protein; Provisional; Region: PRK10867 632772020654 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 632772020655 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 632772020656 P loop; other site 632772020657 GTP binding site [chemical binding]; other site 632772020658 Signal peptide binding domain; Region: SRP_SPB; pfam02978 632772020659 Amidohydrolase; Region: Amidohydro_4; pfam13147 632772020660 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 632772020661 active site 632772020662 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 632772020663 hypothetical protein; Provisional; Region: PRK02821 632772020664 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 632772020665 G-X-X-G motif; other site 632772020666 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 632772020667 RimM N-terminal domain; Region: RimM; pfam01782 632772020668 PRC-barrel domain; Region: PRC; pfam05239 632772020669 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 632772020670 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 632772020671 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 632772020672 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 632772020673 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 632772020674 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 632772020675 RNA binding site [nucleotide binding]; other site 632772020676 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 632772020677 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 632772020678 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 632772020679 Catalytic site [active] 632772020680 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 632772020681 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 632772020682 RNA/DNA hybrid binding site [nucleotide binding]; other site 632772020683 active site 632772020684 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 632772020685 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 632772020686 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 632772020687 active site 632772020688 nucleophile elbow; other site 632772020689 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772020690 metabolite-proton symporter; Region: 2A0106; TIGR00883 632772020691 putative substrate translocation pore; other site 632772020692 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 632772020693 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 632772020694 active site 632772020695 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 632772020696 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 632772020697 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 632772020698 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 632772020699 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 632772020700 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 632772020701 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 632772020702 hypothetical protein; Reviewed; Region: PRK12497 632772020703 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 632772020704 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 632772020705 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632772020706 Walker A motif; other site 632772020707 ATP binding site [chemical binding]; other site 632772020708 Walker B motif; other site 632772020709 arginine finger; other site 632772020710 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 632772020711 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 632772020712 DNA protecting protein DprA; Region: dprA; TIGR00732 632772020713 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 632772020714 putative hydrophobic ligand binding site [chemical binding]; other site 632772020715 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632772020716 dimerization interface [polypeptide binding]; other site 632772020717 putative DNA binding site [nucleotide binding]; other site 632772020718 putative Zn2+ binding site [ion binding]; other site 632772020719 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 632772020720 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 632772020721 FAD binding pocket [chemical binding]; other site 632772020722 FAD binding motif [chemical binding]; other site 632772020723 phosphate binding motif [ion binding]; other site 632772020724 NAD binding pocket [chemical binding]; other site 632772020725 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772020726 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 632772020727 putative substrate translocation pore; other site 632772020728 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 632772020729 Peptidase family M23; Region: Peptidase_M23; pfam01551 632772020730 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 632772020731 rRNA interaction site [nucleotide binding]; other site 632772020732 S8 interaction site; other site 632772020733 putative laminin-1 binding site; other site 632772020734 elongation factor Ts; Provisional; Region: tsf; PRK09377 632772020735 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 632772020736 Elongation factor TS; Region: EF_TS; pfam00889 632772020737 Elongation factor TS; Region: EF_TS; pfam00889 632772020738 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 632772020739 putative nucleotide binding site [chemical binding]; other site 632772020740 uridine monophosphate binding site [chemical binding]; other site 632772020741 homohexameric interface [polypeptide binding]; other site 632772020742 ribosome recycling factor; Reviewed; Region: frr; PRK00083 632772020743 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 632772020744 hinge region; other site 632772020745 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 632772020746 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 632772020747 Methyltransferase domain; Region: Methyltransf_23; pfam13489 632772020748 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772020749 S-adenosylmethionine binding site [chemical binding]; other site 632772020750 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 632772020751 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 632772020752 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 632772020753 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632772020754 FeS/SAM binding site; other site 632772020755 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 632772020756 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 632772020757 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 632772020758 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 632772020759 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 632772020760 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 632772020761 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 632772020762 active site 632772020763 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 632772020764 protein binding site [polypeptide binding]; other site 632772020765 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 632772020766 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 632772020767 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 632772020768 Predicted acetyltransferase [General function prediction only]; Region: COG3393 632772020769 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 632772020770 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 632772020771 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 632772020772 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 632772020773 glucosamine:fructose-6-phosphate aminotransferase; Region: PLN02981 632772020774 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 632772020775 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 632772020776 amino acid transporter; Region: 2A0306; TIGR00909 632772020777 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632772020778 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632772020779 DNA binding residues [nucleotide binding] 632772020780 dimerization interface [polypeptide binding]; other site 632772020781 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 632772020782 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772020783 acyl-activating enzyme (AAE) consensus motif; other site 632772020784 AMP binding site [chemical binding]; other site 632772020785 active site 632772020786 CoA binding site [chemical binding]; other site 632772020787 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 632772020788 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772020789 dimer interface [polypeptide binding]; other site 632772020790 conserved gate region; other site 632772020791 ABC-ATPase subunit interface; other site 632772020792 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 632772020793 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772020794 dimer interface [polypeptide binding]; other site 632772020795 conserved gate region; other site 632772020796 putative PBP binding loops; other site 632772020797 ABC-ATPase subunit interface; other site 632772020798 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 632772020799 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632772020800 Walker A/P-loop; other site 632772020801 ATP binding site [chemical binding]; other site 632772020802 Q-loop/lid; other site 632772020803 ABC transporter signature motif; other site 632772020804 Walker B; other site 632772020805 D-loop; other site 632772020806 H-loop/switch region; other site 632772020807 TOBE domain; Region: TOBE_2; pfam08402 632772020808 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 632772020809 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 632772020810 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 632772020811 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772020812 DNA-binding site [nucleotide binding]; DNA binding site 632772020813 UTRA domain; Region: UTRA; pfam07702 632772020814 Plant protein of unknown function (DUF936); Region: DUF936; pfam06075 632772020815 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 632772020816 active site 632772020817 cobyric acid synthase; Provisional; Region: PRK00784 632772020818 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 632772020819 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 632772020820 catalytic triad [active] 632772020821 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 632772020822 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 632772020823 Walker A/P-loop; other site 632772020824 ATP binding site [chemical binding]; other site 632772020825 Q-loop/lid; other site 632772020826 ABC transporter signature motif; other site 632772020827 Walker B; other site 632772020828 D-loop; other site 632772020829 H-loop/switch region; other site 632772020830 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772020831 DNA-binding site [nucleotide binding]; DNA binding site 632772020832 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 632772020833 hypothetical protein; Provisional; Region: PRK02237 632772020834 mycothione reductase; Reviewed; Region: PRK07846 632772020835 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 632772020836 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 632772020837 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 632772020838 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 632772020839 malate:quinone oxidoreductase; Validated; Region: PRK05257 632772020840 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 632772020841 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 632772020842 Coenzyme A binding pocket [chemical binding]; other site 632772020843 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 632772020844 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632772020845 Walker A motif; other site 632772020846 ATP binding site [chemical binding]; other site 632772020847 Walker B motif; other site 632772020848 arginine finger; other site 632772020849 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 632772020850 metal ion-dependent adhesion site (MIDAS); other site 632772020851 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 632772020852 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 632772020853 Walker A motif; other site 632772020854 homodimer interface [polypeptide binding]; other site 632772020855 ATP binding site [chemical binding]; other site 632772020856 hydroxycobalamin binding site [chemical binding]; other site 632772020857 Walker B motif; other site 632772020858 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 632772020859 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 632772020860 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 632772020861 catalytic triad [active] 632772020862 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 632772020863 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 632772020864 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 632772020865 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 632772020866 homodimer interface [polypeptide binding]; other site 632772020867 active site 632772020868 SAM binding site [chemical binding]; other site 632772020869 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 632772020870 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772020871 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 632772020872 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 632772020873 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 632772020874 active site 632772020875 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 632772020876 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632772020877 active site 632772020878 phosphorylation site [posttranslational modification] 632772020879 intermolecular recognition site; other site 632772020880 dimerization interface [polypeptide binding]; other site 632772020881 Transcriptional regulator; Region: CitT; pfam12431 632772020882 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 632772020883 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 632772020884 putative active site [active] 632772020885 heme pocket [chemical binding]; other site 632772020886 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 632772020887 ATP binding site [chemical binding]; other site 632772020888 Mg2+ binding site [ion binding]; other site 632772020889 G-X-G motif; other site 632772020890 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 632772020891 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 632772020892 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 632772020893 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 632772020894 Ligand Binding Site [chemical binding]; other site 632772020895 hypothetical protein; Validated; Region: PRK02101 632772020896 prolyl-tRNA synthetase; Provisional; Region: PRK09194 632772020897 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 632772020898 motif 1; other site 632772020899 dimer interface [polypeptide binding]; other site 632772020900 active site 632772020901 motif 2; other site 632772020902 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 632772020903 putative deacylase active site [active] 632772020904 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 632772020905 active site 632772020906 motif 3; other site 632772020907 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 632772020908 anticodon binding site; other site 632772020909 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772020910 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 632772020911 active site 632772020912 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 632772020913 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 632772020914 TAP-like protein; Region: Abhydrolase_4; pfam08386 632772020915 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 632772020916 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 632772020917 phosphopeptide binding site; other site 632772020918 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632772020919 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632772020920 DNA binding residues [nucleotide binding] 632772020921 dimerization interface [polypeptide binding]; other site 632772020922 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772020923 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772020924 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 632772020925 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772020926 putative substrate translocation pore; other site 632772020927 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632772020928 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 632772020929 active site 632772020930 phosphorylation site [posttranslational modification] 632772020931 intermolecular recognition site; other site 632772020932 dimerization interface [polypeptide binding]; other site 632772020933 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632772020934 DNA binding residues [nucleotide binding] 632772020935 dimerization interface [polypeptide binding]; other site 632772020936 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 632772020937 Histidine kinase; Region: HisKA_3; pfam07730 632772020938 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 632772020939 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 632772020940 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 632772020941 Walker A/P-loop; other site 632772020942 ATP binding site [chemical binding]; other site 632772020943 Q-loop/lid; other site 632772020944 ABC transporter signature motif; other site 632772020945 Walker B; other site 632772020946 D-loop; other site 632772020947 H-loop/switch region; other site 632772020948 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 632772020949 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772020950 short chain dehydrogenase; Provisional; Region: PRK08303 632772020951 NAD(P) binding site [chemical binding]; other site 632772020952 active site 632772020953 SnoaL-like domain; Region: SnoaL_4; pfam13577 632772020954 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 632772020955 dinuclear metal binding motif [ion binding]; other site 632772020956 ribosome maturation protein RimP; Reviewed; Region: PRK00092 632772020957 Sm and related proteins; Region: Sm_like; cl00259 632772020958 heptamer interface [polypeptide binding]; other site 632772020959 Sm1 motif; other site 632772020960 hexamer interface [polypeptide binding]; other site 632772020961 RNA binding site [nucleotide binding]; other site 632772020962 Sm2 motif; other site 632772020963 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 632772020964 NusA N-terminal domain; Region: NusA_N; pfam08529 632772020965 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 632772020966 RNA binding site [nucleotide binding]; other site 632772020967 homodimer interface [polypeptide binding]; other site 632772020968 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 632772020969 G-X-X-G motif; other site 632772020970 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 632772020971 G-X-X-G motif; other site 632772020972 Protein of unknown function (DUF448); Region: DUF448; pfam04296 632772020973 putative RNA binding cleft [nucleotide binding]; other site 632772020974 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 632772020975 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 632772020976 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 632772020977 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 632772020978 G1 box; other site 632772020979 putative GEF interaction site [polypeptide binding]; other site 632772020980 GTP/Mg2+ binding site [chemical binding]; other site 632772020981 Switch I region; other site 632772020982 G2 box; other site 632772020983 G3 box; other site 632772020984 Switch II region; other site 632772020985 G4 box; other site 632772020986 G5 box; other site 632772020987 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 632772020988 Translation-initiation factor 2; Region: IF-2; pfam11987 632772020989 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 632772020990 Protein of unknown function (DUF503); Region: DUF503; pfam04456 632772020991 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 632772020992 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 632772020993 DHH family; Region: DHH; pfam01368 632772020994 DHHA1 domain; Region: DHHA1; pfam02272 632772020995 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 632772020996 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 632772020997 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 632772020998 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 632772020999 active site 632772021000 metal binding site [ion binding]; metal-binding site 632772021001 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 632772021002 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 632772021003 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 632772021004 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 632772021005 RNA binding site [nucleotide binding]; other site 632772021006 active site 632772021007 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 632772021008 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 632772021009 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 632772021010 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 632772021011 FeoA domain; Region: FeoA; pfam04023 632772021012 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 632772021013 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 632772021014 active site 632772021015 Riboflavin kinase; Region: Flavokinase; smart00904 632772021016 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 632772021017 16S/18S rRNA binding site [nucleotide binding]; other site 632772021018 S13e-L30e interaction site [polypeptide binding]; other site 632772021019 25S rRNA binding site [nucleotide binding]; other site 632772021020 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 632772021021 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 632772021022 oligomer interface [polypeptide binding]; other site 632772021023 RNA binding site [nucleotide binding]; other site 632772021024 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 632772021025 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 632772021026 RNase E interface [polypeptide binding]; other site 632772021027 trimer interface [polypeptide binding]; other site 632772021028 active site 632772021029 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 632772021030 putative nucleic acid binding region [nucleotide binding]; other site 632772021031 G-X-X-G motif; other site 632772021032 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 632772021033 RNA binding site [nucleotide binding]; other site 632772021034 domain interface; other site 632772021035 SCP-2 sterol transfer family; Region: SCP2; pfam02036 632772021036 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 632772021037 S-formylglutathione hydrolase; Region: PLN02442 632772021038 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 632772021039 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 632772021040 putative NAD(P) binding site [chemical binding]; other site 632772021041 Transcriptional regulator [Transcription]; Region: LysR; COG0583 632772021042 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 632772021043 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 632772021044 putative dimerization interface [polypeptide binding]; other site 632772021045 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 632772021046 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772021047 putative substrate translocation pore; other site 632772021048 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 632772021049 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 632772021050 mce related protein; Region: MCE; pfam02470 632772021051 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 632772021052 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 632772021053 Catalytic domain of Protein Kinases; Region: PKc; cd00180 632772021054 active site 632772021055 ATP binding site [chemical binding]; other site 632772021056 substrate binding site [chemical binding]; other site 632772021057 activation loop (A-loop); other site 632772021058 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772021059 S-adenosylmethionine binding site [chemical binding]; other site 632772021060 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 632772021061 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 632772021062 NAD(P) binding site [chemical binding]; other site 632772021063 catalytic residues [active] 632772021064 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 632772021065 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 632772021066 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 632772021067 DNA binding residues [nucleotide binding] 632772021068 Resolvase, N terminal domain; Region: Resolvase; smart00857 632772021069 catalytic residues [active] 632772021070 catalytic nucleophile [active] 632772021071 Domain of unknown function DUF77; Region: DUF77; pfam01910 632772021072 Predicted transcriptional regulator [Transcription]; Region: COG2378 632772021073 HTH domain; Region: HTH_11; pfam08279 632772021074 WYL domain; Region: WYL; pfam13280 632772021075 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 632772021076 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 632772021077 active site 632772021078 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 632772021079 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 632772021080 DinB superfamily; Region: DinB_2; pfam12867 632772021081 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 632772021082 putative methyltransferase; Provisional; Region: PRK14967 632772021083 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772021084 S-adenosylmethionine binding site [chemical binding]; other site 632772021085 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 632772021086 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 632772021087 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 632772021088 molybdopterin cofactor binding site; other site 632772021089 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 632772021090 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 632772021091 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 632772021092 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 632772021093 molybdopterin cofactor binding site; other site 632772021094 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 632772021095 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 632772021096 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 632772021097 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 632772021098 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 632772021099 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 632772021100 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 632772021101 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 632772021102 NAD(P) binding site [chemical binding]; other site 632772021103 Transcriptional regulators [Transcription]; Region: MarR; COG1846 632772021104 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 632772021105 TIGR03086 family protein; Region: TIGR03086 632772021106 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 632772021107 dihydrodipicolinate reductase; Provisional; Region: PRK00048 632772021108 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 632772021109 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 632772021110 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 632772021111 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 632772021112 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 632772021113 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 632772021114 putative hydrophobic ligand binding site [chemical binding]; other site 632772021115 HicB family; Region: HicB; pfam05534 632772021116 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 632772021117 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 632772021118 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 632772021119 dimer interface [polypeptide binding]; other site 632772021120 active site 632772021121 catalytic residue [active] 632772021122 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 632772021123 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 632772021124 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 632772021125 TIGR03085 family protein; Region: TIGR03085 632772021126 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 632772021127 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 632772021128 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 632772021129 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 632772021130 YCII-related domain; Region: YCII; cl00999 632772021131 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 632772021132 Coenzyme A binding pocket [chemical binding]; other site 632772021133 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 632772021134 Competence-damaged protein; Region: CinA; pfam02464 632772021135 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 632772021136 non-specific DNA binding site [nucleotide binding]; other site 632772021137 salt bridge; other site 632772021138 sequence-specific DNA binding site [nucleotide binding]; other site 632772021139 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 632772021140 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 632772021141 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772021142 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772021143 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 632772021144 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 632772021145 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 632772021146 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 632772021147 recombinase A; Provisional; Region: recA; PRK09354 632772021148 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 632772021149 hexamer interface [polypeptide binding]; other site 632772021150 Walker A motif; other site 632772021151 ATP binding site [chemical binding]; other site 632772021152 Walker B motif; other site 632772021153 recombination regulator RecX; Reviewed; Region: recX; PRK00117 632772021154 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772021155 dimer interface [polypeptide binding]; other site 632772021156 conserved gate region; other site 632772021157 putative PBP binding loops; other site 632772021158 ABC-ATPase subunit interface; other site 632772021159 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 632772021160 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772021161 dimer interface [polypeptide binding]; other site 632772021162 conserved gate region; other site 632772021163 putative PBP binding loops; other site 632772021164 ABC-ATPase subunit interface; other site 632772021165 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 632772021166 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 632772021167 substrate binding pocket [chemical binding]; other site 632772021168 membrane-bound complex binding site; other site 632772021169 hinge residues; other site 632772021170 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 632772021171 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 632772021172 Walker A/P-loop; other site 632772021173 ATP binding site [chemical binding]; other site 632772021174 Q-loop/lid; other site 632772021175 ABC transporter signature motif; other site 632772021176 Walker B; other site 632772021177 D-loop; other site 632772021178 H-loop/switch region; other site 632772021179 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 632772021180 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 632772021181 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632772021182 FeS/SAM binding site; other site 632772021183 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 632772021184 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 632772021185 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 632772021186 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 632772021187 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 632772021188 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 632772021189 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 632772021190 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 632772021191 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 632772021192 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 632772021193 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 632772021194 GTPases [General function prediction only]; Region: HflX; COG2262 632772021195 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 632772021196 HflX GTPase family; Region: HflX; cd01878 632772021197 G1 box; other site 632772021198 GTP/Mg2+ binding site [chemical binding]; other site 632772021199 Switch I region; other site 632772021200 G2 box; other site 632772021201 G3 box; other site 632772021202 Switch II region; other site 632772021203 G4 box; other site 632772021204 G5 box; other site 632772021205 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 632772021206 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 632772021207 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 632772021208 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 632772021209 active site 632772021210 phosphorylation site [posttranslational modification] 632772021211 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 632772021212 active site 632772021213 P-loop; other site 632772021214 phosphorylation site [posttranslational modification] 632772021215 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 632772021216 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 632772021217 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 632772021218 putative substrate binding site [chemical binding]; other site 632772021219 putative ATP binding site [chemical binding]; other site 632772021220 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 632772021221 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 632772021222 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 632772021223 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 632772021224 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 632772021225 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 632772021226 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 632772021227 uracil transporter; Provisional; Region: PRK10720 632772021228 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 632772021229 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772021230 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772021231 active site 632772021232 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 632772021233 LexA repressor; Validated; Region: PRK00215 632772021234 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 632772021235 Catalytic site [active] 632772021236 LysM domain; Region: LysM; pfam01476 632772021237 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 632772021238 ATP cone domain; Region: ATP-cone; pfam03477 632772021239 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 632772021240 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 632772021241 ATP binding site [chemical binding]; other site 632772021242 putative Mg++ binding site [ion binding]; other site 632772021243 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 632772021244 nucleotide binding region [chemical binding]; other site 632772021245 ATP-binding site [chemical binding]; other site 632772021246 Helicase associated domain (HA2); Region: HA2; pfam04408 632772021247 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 632772021248 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 632772021249 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 632772021250 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 632772021251 TAP-like protein; Region: Abhydrolase_4; pfam08386 632772021252 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 632772021253 active site 632772021254 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772021255 metabolite-proton symporter; Region: 2A0106; TIGR00883 632772021256 putative substrate translocation pore; other site 632772021257 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 632772021258 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 632772021259 inhibitor-cofactor binding pocket; inhibition site 632772021260 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632772021261 catalytic residue [active] 632772021262 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 632772021263 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 632772021264 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 632772021265 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 632772021266 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 632772021267 dimerization interface [polypeptide binding]; other site 632772021268 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 632772021269 dimerization interface [polypeptide binding]; other site 632772021270 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 632772021271 ATP binding site [chemical binding]; other site 632772021272 putative Mg++ binding site [ion binding]; other site 632772021273 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 632772021274 nucleotide binding region [chemical binding]; other site 632772021275 ATP-binding site [chemical binding]; other site 632772021276 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 632772021277 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 632772021278 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 632772021279 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 632772021280 PAC2 family; Region: PAC2; pfam09754 632772021281 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 632772021282 PknH-like extracellular domain; Region: PknH_C; pfam14032 632772021283 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 632772021284 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 632772021285 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 632772021286 NAD binding site [chemical binding]; other site 632772021287 homodimer interface [polypeptide binding]; other site 632772021288 active site 632772021289 substrate binding site [chemical binding]; other site 632772021290 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 632772021291 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 632772021292 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 632772021293 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 632772021294 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 632772021295 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 632772021296 active site 632772021297 Zn binding site [ion binding]; other site 632772021298 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 632772021299 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 632772021300 Coenzyme A binding pocket [chemical binding]; other site 632772021301 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 632772021302 CoA binding domain; Region: CoA_binding_2; pfam13380 632772021303 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 632772021304 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 632772021305 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 632772021306 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 632772021307 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632772021308 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 632772021309 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 632772021310 DNA binding residues [nucleotide binding] 632772021311 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 632772021312 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772021313 S-adenosylmethionine binding site [chemical binding]; other site 632772021314 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 632772021315 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 632772021316 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 632772021317 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 632772021318 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 632772021319 ATP binding site [chemical binding]; other site 632772021320 putative Mg++ binding site [ion binding]; other site 632772021321 Protein of unknown function (DUF952); Region: DUF952; pfam06108 632772021322 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 632772021323 TrkA-C domain; Region: TrkA_C; pfam02080 632772021324 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 632772021325 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 632772021326 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 632772021327 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632772021328 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 632772021329 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 632772021330 DNA binding residues [nucleotide binding] 632772021331 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 632772021332 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 632772021333 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 632772021334 active site 632772021335 dimerization interface [polypeptide binding]; other site 632772021336 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 632772021337 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 632772021338 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 632772021339 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 632772021340 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 632772021341 trimer interface [polypeptide binding]; other site 632772021342 active site 632772021343 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 632772021344 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 632772021345 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 632772021346 generic binding surface II; other site 632772021347 ssDNA binding site; other site 632772021348 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 632772021349 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 632772021350 TrkA-N domain; Region: TrkA_N; pfam02254 632772021351 TrkA-C domain; Region: TrkA_C; pfam02080 632772021352 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 632772021353 TrkA-N domain; Region: TrkA_N; pfam02254 632772021354 TrkA-C domain; Region: TrkA_C; pfam02080 632772021355 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 632772021356 TRAM domain; Region: TRAM; pfam01938 632772021357 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 632772021358 Transcriptional regulators [Transcription]; Region: MarR; COG1846 632772021359 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632772021360 putative DNA binding site [nucleotide binding]; other site 632772021361 putative Zn2+ binding site [ion binding]; other site 632772021362 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 632772021363 ABC-2 type transporter; Region: ABC2_membrane; cl17235 632772021364 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 632772021365 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632772021366 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 632772021367 Walker A/P-loop; other site 632772021368 ATP binding site [chemical binding]; other site 632772021369 Q-loop/lid; other site 632772021370 ABC transporter signature motif; other site 632772021371 Walker B; other site 632772021372 D-loop; other site 632772021373 H-loop/switch region; other site 632772021374 glutaminase; Provisional; Region: PRK00971 632772021375 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 632772021376 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 632772021377 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 632772021378 ligand binding site [chemical binding]; other site 632772021379 flexible hinge region; other site 632772021380 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 632772021381 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 632772021382 TPP-binding site; other site 632772021383 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 632772021384 PYR/PP interface [polypeptide binding]; other site 632772021385 dimer interface [polypeptide binding]; other site 632772021386 TPP binding site [chemical binding]; other site 632772021387 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 632772021388 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 632772021389 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772021390 putative substrate translocation pore; other site 632772021391 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772021392 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 632772021393 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 632772021394 intersubunit interface [polypeptide binding]; other site 632772021395 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 632772021396 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772021397 DNA-binding site [nucleotide binding]; DNA binding site 632772021398 UTRA domain; Region: UTRA; pfam07702 632772021399 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 632772021400 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 632772021401 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 632772021402 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 632772021403 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772021404 dimer interface [polypeptide binding]; other site 632772021405 conserved gate region; other site 632772021406 putative PBP binding loops; other site 632772021407 ABC-ATPase subunit interface; other site 632772021408 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 632772021409 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 632772021410 Walker A/P-loop; other site 632772021411 ATP binding site [chemical binding]; other site 632772021412 Q-loop/lid; other site 632772021413 ABC transporter signature motif; other site 632772021414 Walker B; other site 632772021415 D-loop; other site 632772021416 H-loop/switch region; other site 632772021417 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 632772021418 L-aspartate oxidase; Provisional; Region: PRK06175 632772021419 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 632772021420 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772021421 substrate binding site [chemical binding]; other site 632772021422 oxyanion hole (OAH) forming residues; other site 632772021423 trimer interface [polypeptide binding]; other site 632772021424 3-hydroxybutyryl-CoA dehydrogenase; Region: PLN02545 632772021425 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 632772021426 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 632772021427 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 632772021428 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 632772021429 dimer interface [polypeptide binding]; other site 632772021430 active site 632772021431 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 632772021432 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 632772021433 catalytic site [active] 632772021434 putative active site [active] 632772021435 putative substrate binding site [chemical binding]; other site 632772021436 Helicase and RNase D C-terminal; Region: HRDC; smart00341 632772021437 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 632772021438 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 632772021439 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 632772021440 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 632772021441 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 632772021442 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 632772021443 substrate binding site [chemical binding]; other site 632772021444 active site 632772021445 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 632772021446 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 632772021447 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 632772021448 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 632772021449 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 632772021450 molybdopterin cofactor binding site [chemical binding]; other site 632772021451 substrate binding site [chemical binding]; other site 632772021452 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 632772021453 molybdopterin cofactor binding site; other site 632772021454 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 632772021455 SelR domain; Region: SelR; pfam01641 632772021456 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 632772021457 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 632772021458 TAP-like protein; Region: Abhydrolase_4; pfam08386 632772021459 hypothetical protein; Provisional; Region: PRK14059 632772021460 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 632772021461 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 632772021462 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 632772021463 Walker A motif; other site 632772021464 ATP binding site [chemical binding]; other site 632772021465 Walker B motif; other site 632772021466 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 632772021467 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 632772021468 Coenzyme A binding pocket [chemical binding]; other site 632772021469 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 632772021470 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 632772021471 hypothetical protein; Reviewed; Region: PRK09588 632772021472 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 632772021473 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 632772021474 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 632772021475 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 632772021476 active site 632772021477 dimer interface [polypeptide binding]; other site 632772021478 motif 1; other site 632772021479 motif 2; other site 632772021480 motif 3; other site 632772021481 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 632772021482 anticodon binding site; other site 632772021483 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 632772021484 nucleotide binding site/active site [active] 632772021485 HIT family signature motif; other site 632772021486 catalytic residue [active] 632772021487 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 632772021488 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 632772021489 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 632772021490 putative acyl-acceptor binding pocket; other site 632772021491 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 632772021492 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 632772021493 LemA family; Region: LemA; cl00742 632772021494 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 632772021495 nudix motif; other site 632772021496 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 632772021497 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 632772021498 active site 632772021499 multimer interface [polypeptide binding]; other site 632772021500 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 632772021501 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 632772021502 active site 632772021503 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 632772021504 catalytic triad [active] 632772021505 dimer interface [polypeptide binding]; other site 632772021506 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 632772021507 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 632772021508 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 632772021509 active site 632772021510 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 632772021511 catalytic triad [active] 632772021512 dimer interface [polypeptide binding]; other site 632772021513 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 632772021514 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13143 632772021515 predicted active site [active] 632772021516 catalytic triad [active] 632772021517 Predicted transcriptional regulators [Transcription]; Region: COG1725 632772021518 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772021519 DNA-binding site [nucleotide binding]; DNA binding site 632772021520 hypothetical protein; Validated; Region: PRK00110 632772021521 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 632772021522 active site 632772021523 putative DNA-binding cleft [nucleotide binding]; other site 632772021524 dimer interface [polypeptide binding]; other site 632772021525 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 632772021526 RuvA N terminal domain; Region: RuvA_N; pfam01330 632772021527 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 632772021528 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 632772021529 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632772021530 Walker A motif; other site 632772021531 ATP binding site [chemical binding]; other site 632772021532 Walker B motif; other site 632772021533 arginine finger; other site 632772021534 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 632772021535 Preprotein translocase subunit; Region: YajC; cl00806 632772021536 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 632772021537 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 632772021538 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 632772021539 Protein export membrane protein; Region: SecD_SecF; pfam02355 632772021540 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 632772021541 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 632772021542 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 632772021543 active site 632772021544 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 632772021545 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 632772021546 Zn2+ binding site [ion binding]; other site 632772021547 Mg2+ binding site [ion binding]; other site 632772021548 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 632772021549 synthetase active site [active] 632772021550 NTP binding site [chemical binding]; other site 632772021551 metal binding site [ion binding]; metal-binding site 632772021552 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 632772021553 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 632772021554 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 632772021555 active site 632772021556 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 632772021557 active site 632772021558 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 632772021559 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 632772021560 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 632772021561 dimer interface [polypeptide binding]; other site 632772021562 motif 1; other site 632772021563 active site 632772021564 motif 2; other site 632772021565 motif 3; other site 632772021566 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 632772021567 anticodon binding site; other site 632772021568 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772021569 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772021570 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 632772021571 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 632772021572 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 632772021573 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 632772021574 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 632772021575 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 632772021576 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 632772021577 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 632772021578 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896 632772021579 putative hydrophobic ligand binding site [chemical binding]; other site 632772021580 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632772021581 dimerization interface [polypeptide binding]; other site 632772021582 putative DNA binding site [nucleotide binding]; other site 632772021583 putative Zn2+ binding site [ion binding]; other site 632772021584 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 632772021585 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 632772021586 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 632772021587 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 632772021588 Zn2+ binding site [ion binding]; other site 632772021589 Mg2+ binding site [ion binding]; other site 632772021590 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632772021591 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632772021592 DNA binding residues [nucleotide binding] 632772021593 dimerization interface [polypeptide binding]; other site 632772021594 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 632772021595 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 632772021596 Walker A/P-loop; other site 632772021597 ATP binding site [chemical binding]; other site 632772021598 Q-loop/lid; other site 632772021599 ABC transporter signature motif; other site 632772021600 Walker B; other site 632772021601 D-loop; other site 632772021602 H-loop/switch region; other site 632772021603 Transcription factor WhiB; Region: Whib; pfam02467 632772021604 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 632772021605 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772021606 S-adenosylmethionine binding site [chemical binding]; other site 632772021607 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 632772021608 Transglycosylase; Region: Transgly; pfam00912 632772021609 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 632772021610 Ion channel; Region: Ion_trans_2; pfam07885 632772021611 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 632772021612 TrkA-N domain; Region: TrkA_N; pfam02254 632772021613 TrkA-C domain; Region: TrkA_C; pfam02080 632772021614 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 632772021615 homotrimer interaction site [polypeptide binding]; other site 632772021616 putative active site [active] 632772021617 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632772021618 Radical SAM superfamily; Region: Radical_SAM; pfam04055 632772021619 FeS/SAM binding site; other site 632772021620 PPOX class probable F420-dependent enzyme, MSMEG_5819 family; Region: PPOX_MSMEG_5819; TIGR04023 632772021621 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 632772021622 hydrophobic ligand binding site; other site 632772021623 Helix-turn-helix domain; Region: HTH_20; pfam12840 632772021624 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 632772021625 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 632772021626 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 632772021627 dimer interface [polypeptide binding]; other site 632772021628 anticodon binding site; other site 632772021629 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 632772021630 homodimer interface [polypeptide binding]; other site 632772021631 motif 1; other site 632772021632 active site 632772021633 motif 2; other site 632772021634 GAD domain; Region: GAD; pfam02938 632772021635 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 632772021636 active site 632772021637 motif 3; other site 632772021638 Domain of unknown function (DUF389); Region: DUF389; cl00781 632772021639 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 632772021640 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 632772021641 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 632772021642 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 632772021643 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 632772021644 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 632772021645 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 632772021646 active site 632772021647 ATP binding site [chemical binding]; other site 632772021648 substrate binding site [chemical binding]; other site 632772021649 recombination factor protein RarA; Reviewed; Region: PRK13342 632772021650 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632772021651 Walker A motif; other site 632772021652 ATP binding site [chemical binding]; other site 632772021653 Walker B motif; other site 632772021654 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 632772021655 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 632772021656 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 632772021657 motif 1; other site 632772021658 active site 632772021659 motif 2; other site 632772021660 motif 3; other site 632772021661 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 632772021662 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 632772021663 YceG-like family; Region: YceG; pfam02618 632772021664 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 632772021665 dimerization interface [polypeptide binding]; other site 632772021666 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 632772021667 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 632772021668 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 632772021669 NAD(P) binding site [chemical binding]; other site 632772021670 shikimate binding site; other site 632772021671 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 632772021672 chorismate synthase; Validated; Region: PRK05382 632772021673 Tetramer interface [polypeptide binding]; other site 632772021674 active site 632772021675 FMN-binding site [chemical binding]; other site 632772021676 shikimate kinase; Reviewed; Region: aroK; PRK00131 632772021677 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 632772021678 ADP binding site [chemical binding]; other site 632772021679 magnesium binding site [ion binding]; other site 632772021680 putative shikimate binding site; other site 632772021681 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 632772021682 active site 632772021683 dimer interface [polypeptide binding]; other site 632772021684 metal binding site [ion binding]; metal-binding site 632772021685 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 632772021686 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 632772021687 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 632772021688 active site 632772021689 elongation factor P; Validated; Region: PRK00529 632772021690 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 632772021691 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 632772021692 RNA binding site [nucleotide binding]; other site 632772021693 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 632772021694 RNA binding site [nucleotide binding]; other site 632772021695 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 632772021696 putative RNA binding site [nucleotide binding]; other site 632772021697 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 632772021698 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 632772021699 active site 632772021700 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 632772021701 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 632772021702 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 632772021703 dihydroorotase; Validated; Region: pyrC; PRK09357 632772021704 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 632772021705 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 632772021706 active site 632772021707 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 632772021708 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 632772021709 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 632772021710 catalytic site [active] 632772021711 subunit interface [polypeptide binding]; other site 632772021712 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 632772021713 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 632772021714 ATP-grasp domain; Region: ATP-grasp_4; cl17255 632772021715 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 632772021716 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 632772021717 ATP-grasp domain; Region: ATP-grasp_4; cl17255 632772021718 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 632772021719 IMP binding site; other site 632772021720 dimer interface [polypeptide binding]; other site 632772021721 interdomain contacts; other site 632772021722 partial ornithine binding site; other site 632772021723 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 632772021724 active site 632772021725 dimer interface [polypeptide binding]; other site 632772021726 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 632772021727 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 632772021728 catalytic site [active] 632772021729 G-X2-G-X-G-K; other site 632772021730 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 632772021731 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 632772021732 Flavoprotein; Region: Flavoprotein; pfam02441 632772021733 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 632772021734 S-adenosylmethionine synthetase; Validated; Region: PRK05250 632772021735 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 632772021736 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 632772021737 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 632772021738 primosome assembly protein PriA; Provisional; Region: PRK14873 632772021739 Predicted transcriptional regulators [Transcription]; Region: COG1695 632772021740 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 632772021741 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 632772021742 Lipase (class 2); Region: Lipase_2; pfam01674 632772021743 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 632772021744 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 632772021745 putative active site [active] 632772021746 substrate binding site [chemical binding]; other site 632772021747 putative cosubstrate binding site; other site 632772021748 catalytic site [active] 632772021749 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 632772021750 substrate binding site [chemical binding]; other site 632772021751 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 632772021752 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 632772021753 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 632772021754 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 632772021755 classical (c) SDRs; Region: SDR_c; cd05233 632772021756 NAD(P) binding site [chemical binding]; other site 632772021757 active site 632772021758 Protein of unknown function (DUF419); Region: DUF419; pfam04237 632772021759 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 632772021760 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 632772021761 substrate binding site [chemical binding]; other site 632772021762 hexamer interface [polypeptide binding]; other site 632772021763 metal binding site [ion binding]; metal-binding site 632772021764 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 632772021765 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 632772021766 catalytic motif [active] 632772021767 Zn binding site [ion binding]; other site 632772021768 RibD C-terminal domain; Region: RibD_C; pfam01872 632772021769 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 632772021770 Lumazine binding domain; Region: Lum_binding; pfam00677 632772021771 Lumazine binding domain; Region: Lum_binding; pfam00677 632772021772 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 632772021773 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 632772021774 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 632772021775 dimerization interface [polypeptide binding]; other site 632772021776 active site 632772021777 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 632772021778 homopentamer interface [polypeptide binding]; other site 632772021779 active site 632772021780 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 632772021781 excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14668 632772021782 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 632772021783 GIY-YIG motif/motif A; other site 632772021784 active site 632772021785 catalytic site [active] 632772021786 putative DNA binding site [nucleotide binding]; other site 632772021787 metal binding site [ion binding]; metal-binding site 632772021788 UvrB/uvrC motif; Region: UVR; pfam02151 632772021789 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 632772021790 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 632772021791 Helix-hairpin-helix motif; Region: HHH; pfam00633 632772021792 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 632772021793 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 632772021794 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 632772021795 phosphate binding site [ion binding]; other site 632772021796 putative substrate binding pocket [chemical binding]; other site 632772021797 dimer interface [polypeptide binding]; other site 632772021798 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 632772021799 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 632772021800 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 632772021801 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 632772021802 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 632772021803 Phosphoglycerate kinase; Region: PGK; pfam00162 632772021804 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 632772021805 substrate binding site [chemical binding]; other site 632772021806 hinge regions; other site 632772021807 ADP binding site [chemical binding]; other site 632772021808 catalytic site [active] 632772021809 triosephosphate isomerase; Provisional; Region: PRK14567 632772021810 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 632772021811 substrate binding site [chemical binding]; other site 632772021812 dimer interface [polypeptide binding]; other site 632772021813 catalytic triad [active] 632772021814 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 632772021815 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 632772021816 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 632772021817 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 632772021818 putative active site [active] 632772021819 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 632772021820 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 632772021821 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 632772021822 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 632772021823 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 632772021824 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 632772021825 putative active site [active] 632772021826 transaldolase; Provisional; Region: PRK03903 632772021827 catalytic residue [active] 632772021828 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 632772021829 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 632772021830 TPP-binding site [chemical binding]; other site 632772021831 dimer interface [polypeptide binding]; other site 632772021832 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 632772021833 PYR/PP interface [polypeptide binding]; other site 632772021834 dimer interface [polypeptide binding]; other site 632772021835 TPP binding site [chemical binding]; other site 632772021836 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 632772021837 UbiA prenyltransferase family; Region: UbiA; pfam01040 632772021838 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 632772021839 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 632772021840 NADP binding site [chemical binding]; other site 632772021841 dimer interface [polypeptide binding]; other site 632772021842 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 632772021843 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 632772021844 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 632772021845 active site 632772021846 catalytic residues [active] 632772021847 DNA binding site [nucleotide binding] 632772021848 Int/Topo IB signature motif; other site 632772021849 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 632772021850 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 632772021851 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 632772021852 active site 632772021853 large terminase protein; Provisional; Region: 17; PHA02533 632772021854 Phage Terminase; Region: Terminase_1; pfam03354 632772021855 Phage-related protein [Function unknown]; Region: COG4695; cl01923 632772021856 Phage portal protein; Region: Phage_portal; pfam04860 632772021857 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 632772021858 Phage capsid family; Region: Phage_capsid; pfam05065 632772021859 Phage-related protein [Function unknown]; Region: COG5412 632772021860 ABC-2 type transporter; Region: ABC2_membrane; cl17235 632772021861 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 632772021862 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 632772021863 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 632772021864 Walker A/P-loop; other site 632772021865 ATP binding site [chemical binding]; other site 632772021866 Q-loop/lid; other site 632772021867 ABC transporter signature motif; other site 632772021868 Walker B; other site 632772021869 D-loop; other site 632772021870 H-loop/switch region; other site 632772021871 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 632772021872 Predicted transcriptional regulator [Transcription]; Region: COG2345 632772021873 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632772021874 putative DNA binding site [nucleotide binding]; other site 632772021875 putative Zn2+ binding site [ion binding]; other site 632772021876 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 632772021877 FeS assembly protein SufB; Region: sufB; TIGR01980 632772021878 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 632772021879 FeS assembly protein SufD; Region: sufD; TIGR01981 632772021880 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 632772021881 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 632772021882 Walker A/P-loop; other site 632772021883 ATP binding site [chemical binding]; other site 632772021884 Q-loop/lid; other site 632772021885 ABC transporter signature motif; other site 632772021886 Walker B; other site 632772021887 D-loop; other site 632772021888 H-loop/switch region; other site 632772021889 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 632772021890 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 632772021891 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 632772021892 catalytic residue [active] 632772021893 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 632772021894 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 632772021895 trimerization site [polypeptide binding]; other site 632772021896 active site 632772021897 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 632772021898 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 632772021899 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 632772021900 putative DNA binding site [nucleotide binding]; other site 632772021901 putative homodimer interface [polypeptide binding]; other site 632772021902 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 632772021903 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 632772021904 NAD binding site [chemical binding]; other site 632772021905 lycopene cyclase; Region: lycopene_cycl; TIGR01789 632772021906 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 632772021907 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632772021908 Walker A/P-loop; other site 632772021909 ATP binding site [chemical binding]; other site 632772021910 Q-loop/lid; other site 632772021911 ABC transporter signature motif; other site 632772021912 Walker B; other site 632772021913 D-loop; other site 632772021914 H-loop/switch region; other site 632772021915 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 632772021916 Winged helix-turn-helix DNA-binding; Region: HTH_35; cl17423 632772021917 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772021918 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772021919 aconitate hydratase; Validated; Region: PRK09277 632772021920 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 632772021921 substrate binding site [chemical binding]; other site 632772021922 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 632772021923 ligand binding site [chemical binding]; other site 632772021924 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 632772021925 substrate binding site [chemical binding]; other site 632772021926 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 632772021927 NlpC/P60 family; Region: NLPC_P60; pfam00877 632772021928 MoxR-like ATPases [General function prediction only]; Region: COG0714 632772021929 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 632772021930 Walker A motif; other site 632772021931 ATP binding site [chemical binding]; other site 632772021932 Walker B motif; other site 632772021933 arginine finger; other site 632772021934 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 632772021935 Protein of unknown function DUF58; Region: DUF58; pfam01882 632772021936 hypothetical protein; Provisional; Region: PRK13685 632772021937 Aerotolerance regulator N-terminal; Region: BatA; cl06567 632772021938 von Willebrand factor type A domain; Region: VWA_2; pfam13519 632772021939 metal ion-dependent adhesion site (MIDAS); other site 632772021940 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 632772021941 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 632772021942 NAD(P) binding site [chemical binding]; other site 632772021943 homotetramer interface [polypeptide binding]; other site 632772021944 homodimer interface [polypeptide binding]; other site 632772021945 active site 632772021946 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 632772021947 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772021948 NAD(P) binding site [chemical binding]; other site 632772021949 active site 632772021950 ferrochelatase; Reviewed; Region: hemH; PRK00035 632772021951 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 632772021952 C-terminal domain interface [polypeptide binding]; other site 632772021953 active site 632772021954 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 632772021955 active site 632772021956 N-terminal domain interface [polypeptide binding]; other site 632772021957 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 632772021958 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 632772021959 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 632772021960 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 632772021961 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 632772021962 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 632772021963 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 632772021964 active site 632772021965 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 632772021966 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 632772021967 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 632772021968 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 632772021969 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 632772021970 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 632772021971 catalytic residue [active] 632772021972 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 632772021973 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772021974 acyl-activating enzyme (AAE) consensus motif; other site 632772021975 potential frameshift: common BLAST hit: gi|134100837|ref|YP_001106498.1| Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II 632772021976 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 632772021977 active site 632772021978 Uncharacterized conserved protein [Function unknown]; Region: COG0398 632772021979 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 632772021980 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 632772021981 CoenzymeA binding site [chemical binding]; other site 632772021982 subunit interaction site [polypeptide binding]; other site 632772021983 PHB binding site; other site 632772021984 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 632772021985 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 632772021986 heterodimer interface [polypeptide binding]; other site 632772021987 substrate interaction site [chemical binding]; other site 632772021988 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 632772021989 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 632772021990 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 632772021991 active site 632772021992 substrate binding site [chemical binding]; other site 632772021993 coenzyme B12 binding site [chemical binding]; other site 632772021994 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 632772021995 B12 binding site [chemical binding]; other site 632772021996 cobalt ligand [ion binding]; other site 632772021997 membrane ATPase/protein kinase; Provisional; Region: PRK09435 632772021998 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 632772021999 GTP/Mg2+ binding site [chemical binding]; other site 632772022000 G5 box; other site 632772022001 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 632772022002 Walker A; other site 632772022003 G1 box; other site 632772022004 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 632772022005 active site 632772022006 OsmC-like protein; Region: OsmC; cl00767 632772022007 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 632772022008 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 632772022009 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 632772022010 CoA-transferase family III; Region: CoA_transf_3; pfam02515 632772022011 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 632772022012 Domain of unknown function DUF21; Region: DUF21; pfam01595 632772022013 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 632772022014 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 632772022015 Domain of unknown function DUF21; Region: DUF21; pfam01595 632772022016 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 632772022017 Transporter associated domain; Region: CorC_HlyC; smart01091 632772022018 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 632772022019 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 632772022020 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 632772022021 active site 632772022022 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 632772022023 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 632772022024 ATP binding site [chemical binding]; other site 632772022025 Mg++ binding site [ion binding]; other site 632772022026 motif III; other site 632772022027 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 632772022028 nucleotide binding region [chemical binding]; other site 632772022029 ATP-binding site [chemical binding]; other site 632772022030 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 632772022031 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 632772022032 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 632772022033 helicase 45; Provisional; Region: PTZ00424 632772022034 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 632772022035 ATP binding site [chemical binding]; other site 632772022036 Mg++ binding site [ion binding]; other site 632772022037 motif III; other site 632772022038 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 632772022039 nucleotide binding region [chemical binding]; other site 632772022040 ATP-binding site [chemical binding]; other site 632772022041 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 632772022042 Predicted transcriptional regulator [Transcription]; Region: COG3682 632772022043 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 632772022044 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 632772022045 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 632772022046 Walker A/P-loop; other site 632772022047 ATP binding site [chemical binding]; other site 632772022048 Q-loop/lid; other site 632772022049 ABC transporter signature motif; other site 632772022050 Walker B; other site 632772022051 D-loop; other site 632772022052 H-loop/switch region; other site 632772022053 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 632772022054 ABC-ATPase subunit interface; other site 632772022055 dimer interface [polypeptide binding]; other site 632772022056 putative PBP binding regions; other site 632772022057 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 632772022058 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 632772022059 ABC-ATPase subunit interface; other site 632772022060 dimer interface [polypeptide binding]; other site 632772022061 putative PBP binding regions; other site 632772022062 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 632772022063 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 632772022064 hydrophobic ligand binding site; other site 632772022065 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 632772022066 RibD C-terminal domain; Region: RibD_C; cl17279 632772022067 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 632772022068 CoenzymeA binding site [chemical binding]; other site 632772022069 subunit interaction site [polypeptide binding]; other site 632772022070 PHB binding site; other site 632772022071 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 632772022072 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 632772022073 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 632772022074 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 632772022075 AzlC protein; Region: AzlC; pfam03591 632772022076 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 632772022077 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 632772022078 non-specific DNA binding site [nucleotide binding]; other site 632772022079 salt bridge; other site 632772022080 sequence-specific DNA binding site [nucleotide binding]; other site 632772022081 Cupin domain; Region: Cupin_2; cl17218 632772022082 YCII-related domain; Region: YCII; cl00999 632772022083 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 632772022084 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 632772022085 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 632772022086 Spore germination protein; Region: Spore_permease; cl17796 632772022087 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 632772022088 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 632772022089 Ligand Binding Site [chemical binding]; other site 632772022090 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 632772022091 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 632772022092 ABC-ATPase subunit interface; other site 632772022093 dimer interface [polypeptide binding]; other site 632772022094 putative PBP binding regions; other site 632772022095 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 632772022096 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 632772022097 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 632772022098 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 632772022099 metal binding site [ion binding]; metal-binding site 632772022100 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 632772022101 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 632772022102 AsnC family; Region: AsnC_trans_reg; pfam01037 632772022103 YCII-related domain; Region: YCII; cl00999 632772022104 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 632772022105 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 632772022106 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 632772022107 Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117 632772022108 PLD-like domain; Region: PLDc_2; pfam13091 632772022109 homodimer interface [polypeptide binding]; other site 632772022110 putative active site [active] 632772022111 catalytic site [active] 632772022112 AAA domain; Region: AAA_12; pfam13087 632772022113 Serine hydrolase; Region: Ser_hydrolase; cl17834 632772022114 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 632772022115 Transcriptional regulators [Transcription]; Region: PurR; COG1609 632772022116 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 632772022117 DNA binding site [nucleotide binding] 632772022118 domain linker motif; other site 632772022119 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 632772022120 dimerization interface [polypeptide binding]; other site 632772022121 ligand binding site [chemical binding]; other site 632772022122 Transcriptional regulators [Transcription]; Region: PurR; COG1609 632772022123 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 632772022124 DNA binding site [nucleotide binding] 632772022125 domain linker motif; other site 632772022126 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 632772022127 dimerization interface [polypeptide binding]; other site 632772022128 ligand binding site [chemical binding]; other site 632772022129 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 632772022130 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 632772022131 classical (c) SDRs; Region: SDR_c; cd05233 632772022132 NAD(P) binding site [chemical binding]; other site 632772022133 active site 632772022134 potential frameshift: common BLAST hit: gi|111024865|ref|YP_707285.1| transposase, IS4 632772022135 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 632772022136 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 632772022137 NAD binding site [chemical binding]; other site 632772022138 catalytic Zn binding site [ion binding]; other site 632772022139 structural Zn binding site [ion binding]; other site 632772022140 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 632772022141 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 632772022142 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 632772022143 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 632772022144 [2Fe-2S] cluster binding site [ion binding]; other site 632772022145 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 632772022146 This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511 632772022147 putative di-iron ligands [ion binding]; other site 632772022148 Transcriptional regulators [Transcription]; Region: PurR; COG1609 632772022149 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 632772022150 DNA binding site [nucleotide binding] 632772022151 domain linker motif; other site 632772022152 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 632772022153 ligand binding site [chemical binding]; other site 632772022154 dimerization interface [polypeptide binding]; other site 632772022155 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 632772022156 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772022157 putative substrate translocation pore; other site 632772022158 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772022159 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 632772022160 CoA-transferase family III; Region: CoA_transf_3; pfam02515 632772022161 CoA-transferase family III; Region: CoA_transf_3; pfam02515 632772022162 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 632772022163 NADH(P)-binding; Region: NAD_binding_10; pfam13460 632772022164 NAD binding site [chemical binding]; other site 632772022165 substrate binding site [chemical binding]; other site 632772022166 putative active site [active] 632772022167 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 632772022168 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 632772022169 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772022170 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 632772022171 substrate binding site [chemical binding]; other site 632772022172 oxyanion hole (OAH) forming residues; other site 632772022173 trimer interface [polypeptide binding]; other site 632772022174 CoA-transferase family III; Region: CoA_transf_3; pfam02515 632772022175 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 632772022176 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 632772022177 active site 632772022178 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 632772022179 classical (c) SDRs; Region: SDR_c; cd05233 632772022180 NAD(P) binding site [chemical binding]; other site 632772022181 active site 632772022182 3-(2,3-dihydroxyphenyl)propionate dioxygenase; Provisional; Region: mhpB; PRK13370 632772022183 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 632772022184 active site 632772022185 metal binding site [ion binding]; metal-binding site 632772022186 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844 632772022187 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 632772022188 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772022189 acyl-activating enzyme (AAE) consensus motif; other site 632772022190 AMP binding site [chemical binding]; other site 632772022191 active site 632772022192 CoA binding site [chemical binding]; other site 632772022193 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 632772022194 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 632772022195 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 632772022196 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772022197 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632772022198 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772022199 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 632772022200 classical (c) SDRs; Region: SDR_c; cd05233 632772022201 NAD(P) binding site [chemical binding]; other site 632772022202 active site 632772022203 enoyl-CoA hydratase; Provisional; Region: PRK08252 632772022204 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772022205 substrate binding site [chemical binding]; other site 632772022206 oxyanion hole (OAH) forming residues; other site 632772022207 trimer interface [polypeptide binding]; other site 632772022208 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 632772022209 CoA-transferase family III; Region: CoA_transf_3; pfam02515 632772022210 putative CoA-transferase; Provisional; Region: PRK11430 632772022211 CoA-transferase family III; Region: CoA_transf_3; pfam02515 632772022212 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 632772022213 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772022214 acyl-activating enzyme (AAE) consensus motif; other site 632772022215 AMP binding site [chemical binding]; other site 632772022216 active site 632772022217 CoA binding site [chemical binding]; other site 632772022218 Ferredoxin [Energy production and conversion]; Region: COG1146 632772022219 4Fe-4S binding domain; Region: Fer4; pfam00037 632772022220 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772022221 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 632772022222 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772022223 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772022224 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772022225 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772022226 active site 632772022227 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 632772022228 CoA-transferase family III; Region: CoA_transf_3; pfam02515 632772022229 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 632772022230 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 632772022231 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772022232 NAD(P) binding site [chemical binding]; other site 632772022233 active site 632772022234 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772022235 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772022236 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772022237 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772022238 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 632772022239 active site 2 [active] 632772022240 active site 1 [active] 632772022241 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 632772022242 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 632772022243 Phosphotransferase enzyme family; Region: APH; pfam01636 632772022244 putative active site [active] 632772022245 putative substrate binding site [chemical binding]; other site 632772022246 ATP binding site [chemical binding]; other site 632772022247 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 632772022248 probable F420-dependent oxidoreductase, MSMEG_2249 family; Region: F420_MSMEG_2249; TIGR03857 632772022249 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 632772022250 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 632772022251 NAD(P) binding site [chemical binding]; other site 632772022252 catalytic residues [active] 632772022253 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 632772022254 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 632772022255 NAD binding site [chemical binding]; other site 632772022256 catalytic Zn binding site [ion binding]; other site 632772022257 substrate binding site [chemical binding]; other site 632772022258 structural Zn binding site [ion binding]; other site 632772022259 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772022260 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772022261 putative substrate translocation pore; other site 632772022262 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 632772022263 Amidase; Region: Amidase; cl11426 632772022264 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 632772022265 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 632772022266 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632772022267 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772022268 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772022269 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 632772022270 CoA-transferase family III; Region: CoA_transf_3; pfam02515 632772022271 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 632772022272 DUF35 OB-fold domain; Region: DUF35; pfam01796 632772022273 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 632772022274 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 632772022275 active site 632772022276 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 632772022277 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772022278 dimer interface [polypeptide binding]; other site 632772022279 conserved gate region; other site 632772022280 putative PBP binding loops; other site 632772022281 ABC-ATPase subunit interface; other site 632772022282 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 632772022283 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 632772022284 Walker A/P-loop; other site 632772022285 ATP binding site [chemical binding]; other site 632772022286 Q-loop/lid; other site 632772022287 ABC transporter signature motif; other site 632772022288 Walker B; other site 632772022289 D-loop; other site 632772022290 H-loop/switch region; other site 632772022291 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 632772022292 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 632772022293 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 632772022294 Walker A/P-loop; other site 632772022295 ATP binding site [chemical binding]; other site 632772022296 Q-loop/lid; other site 632772022297 ABC transporter signature motif; other site 632772022298 Walker B; other site 632772022299 D-loop; other site 632772022300 H-loop/switch region; other site 632772022301 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 632772022302 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 632772022303 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 632772022304 dimer interface [polypeptide binding]; other site 632772022305 conserved gate region; other site 632772022306 putative PBP binding loops; other site 632772022307 ABC-ATPase subunit interface; other site 632772022308 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_8; cd08495 632772022309 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 632772022310 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 632772022311 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_8; cd08495 632772022312 Amidohydrolase; Region: Amidohydro_2; pfam04909 632772022313 Transcriptional regulator [Transcription]; Region: LysR; COG0583 632772022314 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 632772022315 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 632772022316 dimerization interface [polypeptide binding]; other site 632772022317 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 632772022318 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 632772022319 NAD(P) binding site [chemical binding]; other site 632772022320 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 632772022321 Phosphotransferase enzyme family; Region: APH; pfam01636 632772022322 putative active site [active] 632772022323 putative substrate binding site [chemical binding]; other site 632772022324 ATP binding site [chemical binding]; other site 632772022325 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772022326 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772022327 active site 632772022328 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 632772022329 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 632772022330 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 632772022331 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772022332 NAD(P) binding site [chemical binding]; other site 632772022333 active site 632772022334 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 632772022335 classical (c) SDRs; Region: SDR_c; cd05233 632772022336 NAD(P) binding site [chemical binding]; other site 632772022337 active site 632772022338 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 632772022339 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 632772022340 NAD binding site [chemical binding]; other site 632772022341 catalytic residues [active] 632772022342 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772022343 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 632772022344 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 632772022345 acyl-activating enzyme (AAE) consensus motif; other site 632772022346 putative AMP binding site [chemical binding]; other site 632772022347 putative active site [active] 632772022348 putative CoA binding site [chemical binding]; other site 632772022349 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 632772022350 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772022351 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 632772022352 NAD(P) binding site [chemical binding]; other site 632772022353 active site 632772022354 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 632772022355 hypothetical protein; Provisional; Region: PRK06194 632772022356 classical (c) SDRs; Region: SDR_c; cd05233 632772022357 NAD(P) binding site [chemical binding]; other site 632772022358 active site 632772022359 Amidohydrolase; Region: Amidohydro_2; pfam04909 632772022360 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 632772022361 classical (c) SDRs; Region: SDR_c; cd05233 632772022362 NAD(P) binding site [chemical binding]; other site 632772022363 active site 632772022364 Isochorismatase family; Region: Isochorismatase; pfam00857 632772022365 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 632772022366 catalytic triad [active] 632772022367 conserved cis-peptide bond; other site 632772022368 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 632772022369 Cytochrome P450; Region: p450; cl12078 632772022370 enoyl-CoA hydratase; Provisional; Region: PRK06688 632772022371 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772022372 substrate binding site [chemical binding]; other site 632772022373 oxyanion hole (OAH) forming residues; other site 632772022374 trimer interface [polypeptide binding]; other site 632772022375 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 632772022376 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 632772022377 DUF35 OB-fold domain; Region: DUF35; pfam01796 632772022378 short chain dehydrogenase; Provisional; Region: PRK07791 632772022379 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772022380 NAD(P) binding site [chemical binding]; other site 632772022381 active site 632772022382 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772022383 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 632772022384 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772022385 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772022386 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772022387 active site 632772022388 enoyl-CoA hydratase; Provisional; Region: PRK06190 632772022389 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772022390 substrate binding site [chemical binding]; other site 632772022391 oxyanion hole (OAH) forming residues; other site 632772022392 trimer interface [polypeptide binding]; other site 632772022393 Transcriptional regulators [Transcription]; Region: FadR; COG2186 632772022394 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 632772022395 DNA-binding site [nucleotide binding]; DNA binding site 632772022396 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 632772022397 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 632772022398 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 632772022399 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 632772022400 SnoaL-like domain; Region: SnoaL_2; pfam12680 632772022401 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 632772022402 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 632772022403 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 632772022404 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772022405 acyl-activating enzyme (AAE) consensus motif; other site 632772022406 AMP binding site [chemical binding]; other site 632772022407 active site 632772022408 CoA binding site [chemical binding]; other site 632772022409 thiolase; Provisional; Region: PRK06158 632772022410 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 632772022411 active site 632772022412 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772022413 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772022414 active site 632772022415 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 632772022416 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772022417 active site 632772022418 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 632772022419 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 632772022420 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 632772022421 lipid-transfer protein; Provisional; Region: PRK07855 632772022422 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 632772022423 active site 632772022424 DUF35 OB-fold domain; Region: DUF35; pfam01796 632772022425 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 632772022426 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 632772022427 iron-sulfur cluster [ion binding]; other site 632772022428 [2Fe-2S] cluster binding site [ion binding]; other site 632772022429 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 632772022430 putative alpha subunit interface [polypeptide binding]; other site 632772022431 putative active site [active] 632772022432 putative substrate binding site [chemical binding]; other site 632772022433 Fe binding site [ion binding]; other site 632772022434 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 632772022435 inter-subunit interface; other site 632772022436 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 632772022437 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772022438 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 632772022439 acyl-activating enzyme (AAE) consensus motif; other site 632772022440 acyl-activating enzyme (AAE) consensus motif; other site 632772022441 putative AMP binding site [chemical binding]; other site 632772022442 putative active site [active] 632772022443 putative CoA binding site [chemical binding]; other site 632772022444 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 632772022445 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 632772022446 acyl-activating enzyme (AAE) consensus motif; other site 632772022447 putative AMP binding site [chemical binding]; other site 632772022448 putative active site [active] 632772022449 putative CoA binding site [chemical binding]; other site 632772022450 enoyl-CoA hydratase; Provisional; Region: PRK08260 632772022451 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772022452 substrate binding site [chemical binding]; other site 632772022453 oxyanion hole (OAH) forming residues; other site 632772022454 trimer interface [polypeptide binding]; other site 632772022455 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 632772022456 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 632772022457 NAD(P) binding site [chemical binding]; other site 632772022458 catalytic residues [active] 632772022459 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 632772022460 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 632772022461 dimer interface [polypeptide binding]; other site 632772022462 active site 632772022463 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 632772022464 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 632772022465 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 632772022466 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 632772022467 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 632772022468 dimer interface [polypeptide binding]; other site 632772022469 PYR/PP interface [polypeptide binding]; other site 632772022470 TPP binding site [chemical binding]; other site 632772022471 substrate binding site [chemical binding]; other site 632772022472 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 632772022473 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 632772022474 TPP-binding site [chemical binding]; other site 632772022475 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 632772022476 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 632772022477 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 632772022478 active site 632772022479 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 632772022480 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 632772022481 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 632772022482 CoenzymeA binding site [chemical binding]; other site 632772022483 subunit interaction site [polypeptide binding]; other site 632772022484 PHB binding site; other site 632772022485 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 632772022486 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 632772022487 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 632772022488 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 632772022489 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 632772022490 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 632772022491 catalytic residues [active] 632772022492 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 632772022493 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 632772022494 Transcriptional regulator [Transcription]; Region: IclR; COG1414 632772022495 Bacterial transcriptional regulator; Region: IclR; pfam01614 632772022496 OsmC-like protein; Region: OsmC; pfam02566 632772022497 Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI...; Region: PDI_a_family; cd02961 632772022498 catalytic residues [active] 632772022499 Transposase, Mutator family; Region: Transposase_mut; pfam00872 632772022500 MULE transposase domain; Region: MULE; pfam10551 632772022501 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 632772022502 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 632772022503 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 632772022504 NAD(P) binding site [chemical binding]; other site 632772022505 catalytic residues [active] 632772022506 hypothetical protein; Provisional; Region: PRK06541 632772022507 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 632772022508 inhibitor-cofactor binding pocket; inhibition site 632772022509 pyridoxal 5'-phosphate binding site [chemical binding]; other site 632772022510 catalytic residue [active] 632772022511 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 632772022512 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 632772022513 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 632772022514 non-specific DNA binding site [nucleotide binding]; other site 632772022515 salt bridge; other site 632772022516 sequence-specific DNA binding site [nucleotide binding]; other site 632772022517 Cupin domain; Region: Cupin_2; pfam07883 632772022518 MarR family; Region: MarR_2; pfam12802 632772022519 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632772022520 dimerization interface [polypeptide binding]; other site 632772022521 putative DNA binding site [nucleotide binding]; other site 632772022522 putative Zn2+ binding site [ion binding]; other site 632772022523 Major Facilitator Superfamily; Region: MFS_1; pfam07690 632772022524 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 632772022525 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 632772022526 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 632772022527 CoA binding domain; Region: CoA_binding_2; pfam13380 632772022528 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 632772022529 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 632772022530 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772022531 substrate binding site [chemical binding]; other site 632772022532 oxyanion hole (OAH) forming residues; other site 632772022533 trimer interface [polypeptide binding]; other site 632772022534 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 632772022535 Na binding site [ion binding]; other site 632772022536 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 632772022537 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 632772022538 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772022539 substrate binding site [chemical binding]; other site 632772022540 oxyanion hole (OAH) forming residues; other site 632772022541 trimer interface [polypeptide binding]; other site 632772022542 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 632772022543 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 632772022544 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 632772022545 tetrameric interface [polypeptide binding]; other site 632772022546 NAD binding site [chemical binding]; other site 632772022547 catalytic residues [active] 632772022548 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194 632772022549 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 632772022550 putative active site [active] 632772022551 metal binding site [ion binding]; metal-binding site 632772022552 enoyl-CoA hydratase; Provisional; Region: PRK05862 632772022553 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772022554 substrate binding site [chemical binding]; other site 632772022555 oxyanion hole (OAH) forming residues; other site 632772022556 trimer interface [polypeptide binding]; other site 632772022557 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 632772022558 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 632772022559 NAD(P) binding site [chemical binding]; other site 632772022560 crotonyl-CoA reductase; Region: crotonyl_coA_red; cd08246 632772022561 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 632772022562 putative NAD(P) binding site [chemical binding]; other site 632772022563 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 632772022564 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 632772022565 substrate binding site [chemical binding]; other site 632772022566 oxyanion hole (OAH) forming residues; other site 632772022567 trimer interface [polypeptide binding]; other site 632772022568 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 632772022569 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 632772022570 acyl-activating enzyme (AAE) consensus motif; other site 632772022571 AMP binding site [chemical binding]; other site 632772022572 active site 632772022573 CoA binding site [chemical binding]; other site 632772022574 OsmC-like protein; Region: OsmC; pfam02566 632772022575 shikimate transporter; Provisional; Region: PRK09952 632772022576 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 632772022577 putative substrate translocation pore; other site 632772022578 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 632772022579 dimerization interface [polypeptide binding]; other site 632772022580 putative DNA binding site [nucleotide binding]; other site 632772022581 putative Zn2+ binding site [ion binding]; other site 632772022582 Transcriptional regulator [Transcription]; Region: LysR; COG0583 632772022583 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 632772022584 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 632772022585 dimerization interface [polypeptide binding]; other site 632772022586 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 632772022587 potential frameshift: common BLAST hit: gi|111018166|ref|YP_701138.1| lipoyltransferase 632772022588 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 632772022589 potential frameshift: common BLAST hit: gi|111018166|ref|YP_701138.1| lipoyltransferase 632772022590 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 632772022591 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 632772022592 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 632772022593 AsnC family; Region: AsnC_trans_reg; pfam01037 632772022594 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 632772022595 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 632772022596 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 632772022597 catalytic residue [active] 632772022598 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 632772022599 TPP-binding site [chemical binding]; other site 632772022600 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 632772022601 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 632772022602 E3 interaction surface; other site 632772022603 lipoyl attachment site [posttranslational modification]; other site 632772022604 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 632772022605 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 632772022606 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 632772022607 PYR/PP interface [polypeptide binding]; other site 632772022608 dimer interface [polypeptide binding]; other site 632772022609 TPP binding site [chemical binding]; other site 632772022610 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 632772022611 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 632772022612 TPP-binding site [chemical binding]; other site 632772022613 dimer interface [polypeptide binding]; other site 632772022614 potential frameshift: common BLAST hit: gi|118470996|ref|YP_889350.1| indolepyruvate ferredoxin oxidoreductase 632772022615 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 632772022616 TPP-binding site [chemical binding]; other site 632772022617 potential frameshift: common BLAST hit: gi|118470996|ref|YP_889350.1| indolepyruvate ferredoxin oxidoreductase 632772022618 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 632772022619 potential frameshift: common BLAST hit: gi|119716068|ref|YP_923033.1| indolepyruvate ferredoxin oxidoreductase 632772022620 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 632772022621 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 632772022622 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 632772022623 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 632772022624 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 632772022625 Transposase [DNA replication, recombination, and repair]; Region: COG5421 632772022626 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 632772022627 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 632772022628 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 632772022629 active site 632772022630 DNA binding site [nucleotide binding] 632772022631 Int/Topo IB signature motif; other site 632772022632 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 632772022633 active site 632772022634 DNA binding site [nucleotide binding] 632772022635 Int/Topo IB signature motif; other site 632772022636 potential frameshift: common BLAST hit: gi|119714857|ref|YP_921822.1| phage integrase family protein 632772022637 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 632772022638 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 632772022639 active site 632772022640 Int/Topo IB signature motif; other site 632772022641 DNA binding site [nucleotide binding] 632772022642 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 632772022643 active site 632772022644 DNA binding site [nucleotide binding] 632772022645 Int/Topo IB signature motif; other site 632772022646 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 632772022647 Transposase; Region: DEDD_Tnp_IS110; pfam01548 632772022648 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 632772022649 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 632772022650 Transposase; Region: HTH_Tnp_1; cl17663 632772022651 HTH-like domain; Region: HTH_21; pfam13276 632772022652 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 632772022653 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 632772022654 active site 632772022655 catalytic residues [active] 632772022656 DNA binding site [nucleotide binding] 632772022657 Int/Topo IB signature motif; other site 632772022658 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 632772022659 active site 632772022660 catalytic residues [active] 632772022661 DNA binding site [nucleotide binding] 632772022662 Int/Topo IB signature motif; other site 632772022663 Integrase core domain; Region: rve; pfam00665 632772022664 Integrase core domain; Region: rve_3; pfam13683 632772022665 PhoU domain; Region: PhoU; pfam01895 632772022666 Clp amino terminal domain; Region: Clp_N; pfam02861 632772022667 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 632772022668 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 632772022669 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 632772022670 P-loop; other site 632772022671 Magnesium ion binding site [ion binding]; other site 632772022672 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 632772022673 classical (c) SDRs; Region: SDR_c; cd05233 632772022674 NAD(P) binding site [chemical binding]; other site 632772022675 active site 632772022676 Transposase [DNA replication, recombination, and repair]; Region: COG5421 632772022677 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 632772022678 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 632772022679 non-specific DNA binding site [nucleotide binding]; other site 632772022680 salt bridge; other site 632772022681 sequence-specific DNA binding site [nucleotide binding]; other site 632772022682 Cutinase; Region: Cutinase; pfam01083 632772022683 AAA-like domain; Region: AAA_10; pfam12846 632772022684 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 632772022685 Peptidase family M23; Region: Peptidase_M23; pfam01551 632772022686 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 632772022687 NlpC/P60 family; Region: NLPC_P60; pfam00877 632772022688 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 632772022689 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 632772022690 Walker A motif; other site 632772022691 ATP binding site [chemical binding]; other site 632772022692 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 632772022693 Walker B motif; other site 632772022694 Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; cl17861 632772022695 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 632772022696 Hsp70 protein; Region: HSP70; pfam00012 632772022697 CAAX protease self-immunity; Region: Abi; pfam02517 632772022698 HNH endonuclease; Region: HNH_3; pfam13392 632772022699 ParB-like nuclease domain; Region: ParB; smart00470 632772022700 AAA domain; Region: AAA_22; pfam13401 632772022701 Helix-turn-helix domain; Region: HTH_28; pfam13518 632772022702 Winged helix-turn helix; Region: HTH_29; pfam13551 632772022703 Homeodomain-like domain; Region: HTH_32; pfam13565 632772022704 Integrase core domain; Region: rve; pfam00665 632772022705 Integrase core domain; Region: rve_3; cl15866 632772022706 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 632772022707 Methyltransferase domain; Region: Methyltransf_23; pfam13489 632772022708 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 632772022709 S-adenosylmethionine binding site [chemical binding]; other site 632772022710 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 632772022711 DEAD-like helicases superfamily; Region: DEXDc; smart00487 632772022712 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 632772022713 helicase superfamily c-terminal domain; Region: HELICc; smart00490 632772022714 HicB family; Region: HicB; pfam05534 632772022715 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 632772022716 Protein of unknown function (DUF2774); Region: DUF2774; pfam11242 632772022717 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 632772022718 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 632772022719 catalytic residues [active] 632772022720 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 632772022721 RNAase interaction site [polypeptide binding]; other site 632772022722 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 632772022723 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 632772022724 DNA binding residues [nucleotide binding] 632772022725 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 632772022726 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 632772022727 putative dimer interface [polypeptide binding]; other site 632772022728 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 632772022729 HSP70 interaction site [polypeptide binding]; other site 632772022730 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 632772022731 PhoU domain; Region: PhoU; pfam01895 632772022732 PhoU domain; Region: PhoU; pfam01895 632772022733 multiple promoter invertase; Provisional; Region: mpi; PRK13413 632772022734 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 632772022735 catalytic residues [active] 632772022736 catalytic nucleophile [active] 632772022737 Presynaptic Site I dimer interface [polypeptide binding]; other site 632772022738 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 632772022739 Synaptic Flat tetramer interface [polypeptide binding]; other site 632772022740 Synaptic Site I dimer interface [polypeptide binding]; other site 632772022741 DNA binding site [nucleotide binding] 632772022742 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 632772022743 DNA-binding interface [nucleotide binding]; DNA binding site 632772022744 Lsr2; Region: Lsr2; pfam11774 632772022745 Domain of unknown function (DUF4379); Region: DUF4379; pfam14311 632772022746 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 632772022747 Recombinase; Region: Recombinase; pfam07508 632772022748 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 632772022749 putative active site [active] 632772022750 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 632772022751 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 632772022752 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 632772022753 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 632772022754 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 632772022755 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 632772022756 NADP binding site [chemical binding]; other site 632772022757 active site 632772022758 putative substrate binding site [chemical binding]; other site 632772022759 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 632772022760 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 632772022761 NADP-binding site; other site 632772022762 homotetramer interface [polypeptide binding]; other site 632772022763 substrate binding site [chemical binding]; other site 632772022764 homodimer interface [polypeptide binding]; other site 632772022765 active site 632772022766 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 632772022767 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 632772022768 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 632772022769 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 632772022770 metal-binding site 632772022771 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 632772022772 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 632772022773 putative ADP-binding pocket [chemical binding]; other site 632772022774 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 632772022775 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 632772022776 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 632772022777 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 632772022778 NAD(P) binding site [chemical binding]; other site 632772022779 active site 632772022780 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 632772022781 Bacterial sugar transferase; Region: Bac_transf; pfam02397 632772022782 O-Antigen ligase; Region: Wzy_C; pfam04932 632772022783 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 632772022784 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 632772022785 putative trimer interface [polypeptide binding]; other site 632772022786 putative CoA binding site [chemical binding]; other site 632772022787 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 632772022788 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 632772022789 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 632772022790 DNA binding residues [nucleotide binding] 632772022791 dimerization interface [polypeptide binding]; other site 632772022792 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 632772022793 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 632772022794 DNA binding site [nucleotide binding] 632772022795 dimer interface [polypeptide binding]; other site 632772022796 active site 632772022797 Int/Topo IB signature motif; other site 632772022798 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 632772022799 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 632772022800 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 632772022801 Walker A/P-loop; other site 632772022802 ATP binding site [chemical binding]; other site 632772022803 Q-loop/lid; other site 632772022804 ABC transporter signature motif; other site 632772022805 Walker B; other site 632772022806 D-loop; other site 632772022807 H-loop/switch region; other site 632772022808 Silicon transporter; Region: Silic_transp; pfam03842 632772022809 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 632772022810 Radical SAM superfamily; Region: Radical_SAM; pfam04055 632772022811 FeS/SAM binding site; other site 632772022812 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 632772022813 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 632772022814 active site 632772022815 nucleotide binding site [chemical binding]; other site 632772022816 HIGH motif; other site 632772022817 KMSKS motif; other site 632772022818 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629