-- dump date 20140620_025930 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1435356000001 RES domain; Region: RES; pfam08808 1435356000002 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1435356000003 MULE transposase domain; Region: MULE; pfam10551 1435356000004 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1435356000005 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1435356000006 metal binding triad [ion binding]; metal-binding site 1435356000007 HD domain; Region: HD_4; pfam13328 1435356000008 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1435356000009 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1435356000010 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1435356000011 S-adenosylmethionine binding site [chemical binding]; other site 1435356000012 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 1435356000013 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1435356000014 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1435356000015 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1435356000016 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1435356000017 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1435356000018 ATP binding site [chemical binding]; other site 1435356000019 putative Mg++ binding site [ion binding]; other site 1435356000020 ATP cone domain; Region: ATP-cone; pfam03477 1435356000021 Putative esterase; Region: Esterase; pfam00756 1435356000022 Haemolytic domain; Region: Haemolytic; cl00506 1435356000023 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 1435356000024 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1435356000025 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1435356000026 Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561 1435356000027 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1435356000028 Walker A motif; other site 1435356000029 ATP binding site [chemical binding]; other site 1435356000030 AAA-like domain; Region: AAA_10; pfam12846 1435356000031 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1435356000032 Peptidase family M23; Region: Peptidase_M23; pfam01551 1435356000033 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1435356000034 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1435356000035 catalytic residue [active] 1435356000036 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1435356000037 NlpC/P60 family; Region: NLPC_P60; pfam00877 1435356000038 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1435356000039 Cytochrome P450; Region: p450; cl12078 1435356000040 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1435356000041 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1435356000042 non-specific DNA binding site [nucleotide binding]; other site 1435356000043 salt bridge; other site 1435356000044 sequence-specific DNA binding site [nucleotide binding]; other site 1435356000045 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1435356000046 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1435356000047 salt bridge; other site 1435356000048 non-specific DNA binding site [nucleotide binding]; other site 1435356000049 sequence-specific DNA binding site [nucleotide binding]; other site 1435356000050 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 1435356000051 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1435356000052 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1435356000053 active site 1435356000054 catalytic residues [active] 1435356000055 DNA binding site [nucleotide binding] 1435356000056 Int/Topo IB signature motif; other site 1435356000057 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 1435356000058 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1435356000059 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1435356000060 active site 1435356000061 DNA binding site [nucleotide binding] 1435356000062 Int/Topo IB signature motif; other site 1435356000063 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1435356000064 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1435356000065 TAP-like protein; Region: Abhydrolase_4; pfam08386 1435356000066 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 1435356000067 Abi-like protein; Region: Abi_2; pfam07751 1435356000068 Protein of unknown function (DUF2716); Region: DUF2716; pfam10898 1435356000069 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1435356000070 RNA-binding motif; other site 1435356000071 DNA-binding site [nucleotide binding]; DNA binding site 1435356000072 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1435356000073 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1435356000074 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1435356000075 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356000076 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356000077 Bacterial transcriptional repressor; Region: TetR; pfam13972 1435356000078 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1435356000079 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1435356000080 [2Fe-2S] cluster binding site [ion binding]; other site 1435356000081 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1435356000082 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1435356000083 FMN-binding pocket [chemical binding]; other site 1435356000084 flavin binding motif; other site 1435356000085 phosphate binding motif [ion binding]; other site 1435356000086 beta-alpha-beta structure motif; other site 1435356000087 NAD binding pocket [chemical binding]; other site 1435356000088 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1435356000089 catalytic loop [active] 1435356000090 iron binding site [ion binding]; other site 1435356000091 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1435356000092 homotrimer interaction site [polypeptide binding]; other site 1435356000093 putative active site [active] 1435356000094 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 1435356000095 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1435356000096 conserved cys residue [active] 1435356000097 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1435356000098 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1435356000099 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1435356000100 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 1435356000101 NAD(P) binding site [chemical binding]; other site 1435356000102 catalytic residues [active] 1435356000103 Proline dehydrogenase; Region: Pro_dh; cl03282 1435356000104 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1435356000105 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1435356000106 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1435356000107 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1435356000108 active site 1435356000109 catalytic residues [active] 1435356000110 DNA binding site [nucleotide binding] 1435356000111 Int/Topo IB signature motif; other site 1435356000112 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1435356000113 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1435356000114 active site 1435356000115 DNA binding site [nucleotide binding] 1435356000116 Int/Topo IB signature motif; other site 1435356000117 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1435356000118 MULE transposase domain; Region: MULE; pfam10551 1435356000119 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1435356000120 MULE transposase domain; Region: MULE; pfam10551 1435356000121 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 1435356000122 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1435356000123 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1435356000124 DNA-binding site [nucleotide binding]; DNA binding site 1435356000125 RNA-binding motif; other site 1435356000126 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1435356000127 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1435356000128 catalytic residues [active] 1435356000129 catalytic nucleophile [active] 1435356000130 Presynaptic Site I dimer interface [polypeptide binding]; other site 1435356000131 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1435356000132 Synaptic Flat tetramer interface [polypeptide binding]; other site 1435356000133 Synaptic Site I dimer interface [polypeptide binding]; other site 1435356000134 DNA binding site [nucleotide binding] 1435356000135 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1435356000136 DNA-binding interface [nucleotide binding]; DNA binding site 1435356000137 Protein of unknown function (DUF2716); Region: DUF2716; pfam10898 1435356000138 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1435356000139 RNA binding site [nucleotide binding]; other site 1435356000140 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 1435356000141 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1435356000142 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1435356000143 homodimer interface [polypeptide binding]; other site 1435356000144 NADP binding site [chemical binding]; other site 1435356000145 substrate binding site [chemical binding]; other site 1435356000146 Phosphotransferase enzyme family; Region: APH; pfam01636 1435356000147 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1435356000148 active site 1435356000149 substrate binding site [chemical binding]; other site 1435356000150 ATP binding site [chemical binding]; other site 1435356000151 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 1435356000152 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 1435356000153 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1435356000154 Phosphotransferase enzyme family; Region: APH; pfam01636 1435356000155 substrate binding site [chemical binding]; other site 1435356000156 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1435356000157 RNA binding site [nucleotide binding]; other site 1435356000158 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1435356000159 histidinol-phosphatase; Provisional; Region: PRK05588 1435356000160 active site 1435356000161 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1435356000162 LGFP repeat; Region: LGFP; pfam08310 1435356000163 LGFP repeat; Region: LGFP; pfam08310 1435356000164 LGFP repeat; Region: LGFP; pfam08310 1435356000165 Helicase associated domain; Region: HA; pfam03457 1435356000166 Helicase associated domain; Region: HA; pfam03457 1435356000167 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1435356000168 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1435356000169 Walker A/P-loop; other site 1435356000170 ATP binding site [chemical binding]; other site 1435356000171 Q-loop/lid; other site 1435356000172 ABC transporter signature motif; other site 1435356000173 Walker B; other site 1435356000174 D-loop; other site 1435356000175 H-loop/switch region; other site 1435356000176 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1435356000177 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1435356000178 Walker A/P-loop; other site 1435356000179 ATP binding site [chemical binding]; other site 1435356000180 Q-loop/lid; other site 1435356000181 ABC transporter signature motif; other site 1435356000182 Walker B; other site 1435356000183 D-loop; other site 1435356000184 H-loop/switch region; other site 1435356000185 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1435356000186 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1435356000187 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1435356000188 dimer interface [polypeptide binding]; other site 1435356000189 conserved gate region; other site 1435356000190 putative PBP binding loops; other site 1435356000191 ABC-ATPase subunit interface; other site 1435356000192 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1435356000193 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1435356000194 dimer interface [polypeptide binding]; other site 1435356000195 conserved gate region; other site 1435356000196 putative PBP binding loops; other site 1435356000197 ABC-ATPase subunit interface; other site 1435356000198 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 1435356000199 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1435356000200 Aminoglycoside-2''-adenylyltransferase; Region: Aminoglyc_resit; pfam10706 1435356000201 HTH-like domain; Region: HTH_21; pfam13276 1435356000202 Integrase core domain; Region: rve; pfam00665 1435356000203 Integrase core domain; Region: rve_3; pfam13683 1435356000204 AL1L pseudoknot; Derived by automated computational analysis using gene prediction method: cmsearch. 1435356000205 Transposase; Region: HTH_Tnp_1; cl17663 1435356000206 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1435356000207 phosphate binding motif [ion binding]; other site 1435356000208 beta-alpha-beta structure motif; other site 1435356000209 NAD binding pocket [chemical binding]; other site 1435356000210 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1435356000211 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1435356000212 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1435356000213 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1435356000214 K+-transporting ATPase, c chain; Region: KdpC; cl00944 1435356000215 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1435356000216 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1435356000217 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1435356000218 Ligand Binding Site [chemical binding]; other site 1435356000219 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1435356000220 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1435356000221 dimer interface [polypeptide binding]; other site 1435356000222 phosphorylation site [posttranslational modification] 1435356000223 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1435356000224 Mg2+ binding site [ion binding]; other site 1435356000225 G-X-G motif; other site 1435356000226 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1435356000227 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1435356000228 active site 1435356000229 phosphorylation site [posttranslational modification] 1435356000230 intermolecular recognition site; other site 1435356000231 dimerization interface [polypeptide binding]; other site 1435356000232 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1435356000233 DNA binding site [nucleotide binding] 1435356000234 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 1435356000235 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1435356000236 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1435356000237 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1435356000238 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1435356000239 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1435356000240 NAD(P) binding site [chemical binding]; other site 1435356000241 catalytic residues [active] 1435356000242 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1435356000243 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1435356000244 NAD binding site [chemical binding]; other site 1435356000245 catalytic Zn binding site [ion binding]; other site 1435356000246 substrate binding site [chemical binding]; other site 1435356000247 structural Zn binding site [ion binding]; other site 1435356000248 Siderophore-interacting protein; Region: SIP; pfam04954 1435356000249 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1435356000250 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1435356000251 DNA-binding site [nucleotide binding]; DNA binding site 1435356000252 FCD domain; Region: FCD; pfam07729 1435356000253 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1435356000254 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1435356000255 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1435356000256 MULE transposase domain; Region: MULE; pfam10551 1435356000257 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1435356000258 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1435356000259 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1435356000260 motif II; other site 1435356000261 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1435356000262 Predicted membrane protein [Function unknown]; Region: COG3462 1435356000263 Short C-terminal domain; Region: SHOCT; pfam09851 1435356000264 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 1435356000265 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 1435356000266 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 1435356000267 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1435356000268 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1435356000269 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1435356000270 active site 1435356000271 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 1435356000272 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1435356000273 MULE transposase domain; Region: MULE; pfam10551 1435356000274 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1435356000275 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1435356000276 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1435356000277 putative active site [active] 1435356000278 putative catalytic site [active] 1435356000279 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1435356000280 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1435356000281 DNA-binding site [nucleotide binding]; DNA binding site 1435356000282 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1435356000283 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 1435356000284 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1435356000285 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1435356000286 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1435356000287 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 1435356000288 Amidase; Region: Amidase; cl11426 1435356000289 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1435356000290 Cutinase; Region: Cutinase; pfam01083 1435356000291 RES domain; Region: RES; pfam08808 1435356000292 transposase/IS protein; Provisional; Region: PRK09183 1435356000293 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1435356000294 Walker A motif; other site 1435356000295 ATP binding site [chemical binding]; other site 1435356000296 Walker B motif; other site 1435356000297 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1435356000298 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1435356000299 sequence-specific DNA binding site [nucleotide binding]; other site 1435356000300 salt bridge; other site 1435356000301 Integrase core domain; Region: rve; pfam00665 1435356000302 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1435356000303 MULE transposase domain; Region: MULE; pfam10551 1435356000304 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1435356000305 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1435356000306 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 1435356000307 Helix-turn-helix domain; Region: HTH_17; pfam12728 1435356000308 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1435356000309 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1435356000310 active site 1435356000311 catalytic site [active] 1435356000312 substrate binding site [chemical binding]; other site 1435356000313 Domain of unknown function (DUF3560); Region: DUF3560; pfam12083 1435356000314 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1435356000315 MULE transposase domain; Region: MULE; pfam10551 1435356000316 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1435356000317 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1435356000318 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1435356000319 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1435356000320 MULE transposase domain; Region: MULE; pfam10551 1435356000321 RES domain; Region: RES; pfam08808 1435356000322 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1435356000323 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1435356000324 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1435356000325 amidase; Provisional; Region: PRK07869 1435356000326 Amidase; Region: Amidase; cl11426 1435356000327 Predicted ATPase [General function prediction only]; Region: COG3903 1435356000328 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1435356000329 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1435356000330 DNA binding residues [nucleotide binding] 1435356000331 dimerization interface [polypeptide binding]; other site 1435356000332 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1435356000333 classical (c) SDRs; Region: SDR_c; cd05233 1435356000334 NAD(P) binding site [chemical binding]; other site 1435356000335 active site 1435356000336 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1435356000337 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1435356000338 Integrase core domain; Region: rve; pfam00665 1435356000339 transposase; Provisional; Region: PRK06526 1435356000340 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1435356000341 Walker A motif; other site 1435356000342 ATP binding site [chemical binding]; other site 1435356000343 Walker B motif; other site 1435356000344 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1435356000345 DNA-binding site [nucleotide binding]; DNA binding site 1435356000346 RNA-binding motif; other site 1435356000347 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1435356000348 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1435356000349 Winged helix-turn helix; Region: HTH_29; pfam13551 1435356000350 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1435356000351 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1435356000352 transposase/IS protein; Provisional; Region: PRK09183 1435356000353 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1435356000354 Walker A motif; other site 1435356000355 ATP binding site [chemical binding]; other site 1435356000356 Walker B motif; other site 1435356000357 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1435356000358 Integrase core domain; Region: rve; pfam00665 1435356000359 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1435356000360 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1435356000361 catalytic triad [active] 1435356000362 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1435356000363 Glutaminase; Region: Glutaminase; cl00907 1435356000364 Amino acid permease; Region: AA_permease; pfam00324 1435356000365 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1435356000366 classical (c) SDRs; Region: SDR_c; cd05233 1435356000367 NAD(P) binding site [chemical binding]; other site 1435356000368 active site 1435356000369 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1435356000370 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1435356000371 DNA-binding site [nucleotide binding]; DNA binding site 1435356000372 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1435356000373 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1435356000374 classical (c) SDRs; Region: SDR_c; cd05233 1435356000375 NAD(P) binding site [chemical binding]; other site 1435356000376 active site 1435356000377 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 1435356000378 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1435356000379 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1435356000380 NAD(P) binding site [chemical binding]; other site 1435356000381 active site 1435356000382 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1435356000383 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1435356000384 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1435356000385 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1435356000386 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1435356000387 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1435356000388 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1435356000389 classical (c) SDRs; Region: SDR_c; cd05233 1435356000390 NAD(P) binding site [chemical binding]; other site 1435356000391 active site 1435356000392 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1435356000393 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1435356000394 acetyl-CoA synthetase; Provisional; Region: PRK00174 1435356000395 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1435356000396 active site 1435356000397 CoA binding site [chemical binding]; other site 1435356000398 acyl-activating enzyme (AAE) consensus motif; other site 1435356000399 AMP binding site [chemical binding]; other site 1435356000400 acetate binding site [chemical binding]; other site 1435356000401 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1435356000402 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1435356000403 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1435356000404 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1435356000405 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 1435356000406 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 1435356000407 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1435356000408 putative active site [active] 1435356000409 putative metal-binding site [ion binding]; other site 1435356000410 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1435356000411 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1435356000412 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1435356000413 Walker A/P-loop; other site 1435356000414 ATP binding site [chemical binding]; other site 1435356000415 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1435356000416 sequence-specific DNA binding site [nucleotide binding]; other site 1435356000417 salt bridge; other site 1435356000418 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 1435356000419 Zeta toxin; Region: Zeta_toxin; pfam06414 1435356000420 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1435356000421 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 1435356000422 NAD binding site [chemical binding]; other site 1435356000423 substrate binding site [chemical binding]; other site 1435356000424 catalytic Zn binding site [ion binding]; other site 1435356000425 structural Zn binding site [ion binding]; other site 1435356000426 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1435356000427 RNA binding site [nucleotide binding]; other site 1435356000428 Protein of unknown function (DUF2716); Region: DUF2716; pfam10898 1435356000429 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1435356000430 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1435356000431 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1435356000432 sequence-specific DNA binding site [nucleotide binding]; other site 1435356000433 salt bridge; other site 1435356000434 Integrase core domain; Region: rve; pfam00665 1435356000435 transposase/IS protein; Provisional; Region: PRK09183 1435356000436 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1435356000437 Walker A motif; other site 1435356000438 ATP binding site [chemical binding]; other site 1435356000439 Walker B motif; other site 1435356000440 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1435356000441 dimerization interface [polypeptide binding]; other site 1435356000442 putative DNA binding site [nucleotide binding]; other site 1435356000443 putative Zn2+ binding site [ion binding]; other site 1435356000444 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1435356000445 arsenical-resistance protein; Region: acr3; TIGR00832 1435356000446 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1435356000447 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1435356000448 active site 1435356000449 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1435356000450 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1435356000451 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1435356000452 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1435356000453 active site 1435356000454 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 1435356000455 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1435356000456 putative metal binding site [ion binding]; other site 1435356000457 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1435356000458 putative DNA binding site [nucleotide binding]; other site 1435356000459 putative Zn2+ binding site [ion binding]; other site 1435356000460 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1435356000461 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1435356000462 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1435356000463 Walker A motif; other site 1435356000464 ATP binding site [chemical binding]; other site 1435356000465 AAA-like domain; Region: AAA_10; pfam12846 1435356000466 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1435356000467 Peptidase family M23; Region: Peptidase_M23; pfam01551 1435356000468 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1435356000469 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1435356000470 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1435356000471 catalytic residue [active] 1435356000472 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1435356000473 NlpC/P60 family; Region: NLPC_P60; pfam00877 1435356000474 N-terminal Mad Homology 1 (MH1) domain; Region: MH1; cl00055 1435356000475 DNA binding site [nucleotide binding] 1435356000476 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1435356000477 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1435356000478 non-specific DNA binding site [nucleotide binding]; other site 1435356000479 salt bridge; other site 1435356000480 sequence-specific DNA binding site [nucleotide binding]; other site 1435356000481 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1435356000482 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1435356000483 salt bridge; other site 1435356000484 non-specific DNA binding site [nucleotide binding]; other site 1435356000485 sequence-specific DNA binding site [nucleotide binding]; other site 1435356000486 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1435356000487 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1435356000488 P-loop; other site 1435356000489 Magnesium ion binding site [ion binding]; other site 1435356000490 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1435356000491 Magnesium ion binding site [ion binding]; other site 1435356000492 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 1435356000493 Cutinase; Region: Cutinase; pfam01083 1435356000494 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 1435356000495 active site 1435356000496 conformational flexibility of ligand binding pocket; other site 1435356000497 ADP-ribosylating toxin turn-turn motif; other site 1435356000498 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1435356000499 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 1435356000500 Homeodomain-like domain; Region: HTH_23; pfam13384 1435356000501 Helix-turn-helix domain; Region: HTH_38; pfam13936 1435356000502 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1435356000503 Integrase core domain; Region: rve; pfam00665 1435356000504 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1435356000505 Cytochrome P450; Region: p450; pfam00067 1435356000506 Haemolytic domain; Region: Haemolytic; cl00506 1435356000507 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483 1435356000508 Protein of unknown function (DUF499); Region: DUF499; pfam04465 1435356000509 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 1435356000510 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_a; cd09179 1435356000511 PLD-like domain; Region: PLDc_2; pfam13091 1435356000512 putative active site [active] 1435356000513 catalytic site [active] 1435356000514 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1435356000515 ATP binding site [chemical binding]; other site 1435356000516 putative Mg++ binding site [ion binding]; other site 1435356000517 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1435356000518 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1435356000519 nucleotide binding region [chemical binding]; other site 1435356000520 ATP-binding site [chemical binding]; other site 1435356000521 LabA_like proteins; Region: LabA_like; cd06167 1435356000522 putative metal binding site [ion binding]; other site 1435356000523 DNA protecting protein DprA; Region: dprA; TIGR00732 1435356000524 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1435356000525 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1435356000526 Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; cl09741 1435356000527 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1435356000528 RNA binding site [nucleotide binding]; other site 1435356000529 Replicase family; Region: Replicase; pfam03090 1435356000530 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 1435356000531 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1435356000532 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1435356000533 substrate binding pocket [chemical binding]; other site 1435356000534 membrane-bound complex binding site; other site 1435356000535 hinge residues; other site 1435356000536 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1435356000537 dimer interface [polypeptide binding]; other site 1435356000538 conserved gate region; other site 1435356000539 putative PBP binding loops; other site 1435356000540 ABC-ATPase subunit interface; other site 1435356000541 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1435356000542 putative PBP binding loops; other site 1435356000543 dimer interface [polypeptide binding]; other site 1435356000544 ABC-ATPase subunit interface; other site 1435356000545 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1435356000546 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1435356000547 Walker A/P-loop; other site 1435356000548 ATP binding site [chemical binding]; other site 1435356000549 Q-loop/lid; other site 1435356000550 ABC transporter signature motif; other site 1435356000551 Walker B; other site 1435356000552 D-loop; other site 1435356000553 H-loop/switch region; other site 1435356000554 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1435356000555 dimerization interface [polypeptide binding]; other site 1435356000556 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1435356000557 cyclase homology domain; Region: CHD; cd07302 1435356000558 nucleotidyl binding site; other site 1435356000559 metal binding site [ion binding]; metal-binding site 1435356000560 dimer interface [polypeptide binding]; other site 1435356000561 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 1435356000562 hypothetical protein; Provisional; Region: PRK03298 1435356000563 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1435356000564 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1435356000565 DNA binding residues [nucleotide binding] 1435356000566 drug binding residues [chemical binding]; other site 1435356000567 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 1435356000568 beta-clamp/clamp loader binding surface; other site 1435356000569 beta-clamp/translesion DNA polymerase binding surface; other site 1435356000570 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1435356000571 transcriptional regulator ICP4; Provisional; Region: PHA03307 1435356000572 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1435356000573 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1435356000574 dimer interface [polypeptide binding]; other site 1435356000575 substrate binding site [chemical binding]; other site 1435356000576 metal binding site [ion binding]; metal-binding site 1435356000577 putative acyltransferase; Provisional; Region: PRK05790 1435356000578 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1435356000579 dimer interface [polypeptide binding]; other site 1435356000580 active site 1435356000581 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1435356000582 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1435356000583 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1435356000584 Domain of unknown function (DUF955); Region: DUF955; cl01076 1435356000585 glycogen branching enzyme; Provisional; Region: PRK05402 1435356000586 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1435356000587 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1435356000588 active site 1435356000589 catalytic site [active] 1435356000590 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1435356000591 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1435356000592 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1435356000593 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1435356000594 active site 1435356000595 catalytic site [active] 1435356000596 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 1435356000597 putative homodimer interface [polypeptide binding]; other site 1435356000598 putative active site pocket [active] 1435356000599 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 1435356000600 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1435356000601 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1435356000602 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1435356000603 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1435356000604 Isochorismatase family; Region: Isochorismatase; pfam00857 1435356000605 catalytic triad [active] 1435356000606 metal binding site [ion binding]; metal-binding site 1435356000607 conserved cis-peptide bond; other site 1435356000608 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1435356000609 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1435356000610 active site 1435356000611 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1435356000612 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 1435356000613 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1435356000614 putative active site pocket [active] 1435356000615 cleavage site 1435356000616 Rhomboid family; Region: Rhomboid; cl11446 1435356000617 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1435356000618 ribonuclease PH; Reviewed; Region: rph; PRK00173 1435356000619 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1435356000620 hexamer interface [polypeptide binding]; other site 1435356000621 active site 1435356000622 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1435356000623 active site 1435356000624 dimerization interface [polypeptide binding]; other site 1435356000625 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1435356000626 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1435356000627 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1435356000628 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1435356000629 anti sigma factor interaction site; other site 1435356000630 regulatory phosphorylation site [posttranslational modification]; other site 1435356000631 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1435356000632 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1435356000633 active site 1435356000634 phosphorylation site [posttranslational modification] 1435356000635 intermolecular recognition site; other site 1435356000636 dimerization interface [polypeptide binding]; other site 1435356000637 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1435356000638 CHASE3 domain; Region: CHASE3; pfam05227 1435356000639 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1435356000640 dimerization interface [polypeptide binding]; other site 1435356000641 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1435356000642 dimer interface [polypeptide binding]; other site 1435356000643 phosphorylation site [posttranslational modification] 1435356000644 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1435356000645 ATP binding site [chemical binding]; other site 1435356000646 Mg2+ binding site [ion binding]; other site 1435356000647 G-X-G motif; other site 1435356000648 Response regulator receiver domain; Region: Response_reg; pfam00072 1435356000649 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1435356000650 active site 1435356000651 phosphorylation site [posttranslational modification] 1435356000652 intermolecular recognition site; other site 1435356000653 dimerization interface [polypeptide binding]; other site 1435356000654 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1435356000655 Glucitol operon activator protein (GutM); Region: GutM; cl01890 1435356000656 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1435356000657 active site 1435356000658 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1435356000659 active site 1435356000660 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1435356000661 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 1435356000662 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1435356000663 phosphate binding site [ion binding]; other site 1435356000664 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 1435356000665 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 1435356000666 putative active site [active] 1435356000667 putative catalytic site [active] 1435356000668 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1435356000669 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1435356000670 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 1435356000671 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 1435356000672 putative NAD(P) binding site [chemical binding]; other site 1435356000673 active site 1435356000674 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 1435356000675 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1435356000676 active site 1435356000677 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1435356000678 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356000679 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356000680 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1435356000681 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1435356000682 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1435356000683 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1435356000684 Walker A/P-loop; other site 1435356000685 ATP binding site [chemical binding]; other site 1435356000686 Q-loop/lid; other site 1435356000687 ABC transporter signature motif; other site 1435356000688 Walker B; other site 1435356000689 D-loop; other site 1435356000690 H-loop/switch region; other site 1435356000691 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1435356000692 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356000693 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356000694 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1435356000695 hypothetical protein; Provisional; Region: PRK07907 1435356000696 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 1435356000697 active site 1435356000698 metal binding site [ion binding]; metal-binding site 1435356000699 dimer interface [polypeptide binding]; other site 1435356000700 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1435356000701 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1435356000702 catalytic triad [active] 1435356000703 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1435356000704 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 1435356000705 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1435356000706 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1435356000707 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1435356000708 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1435356000709 Secretory lipase; Region: LIP; pfam03583 1435356000710 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1435356000711 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1435356000712 catalytic site [active] 1435356000713 putative active site [active] 1435356000714 putative substrate binding site [chemical binding]; other site 1435356000715 dimer interface [polypeptide binding]; other site 1435356000716 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1435356000717 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1435356000718 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1435356000719 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1435356000720 classical (c) SDRs; Region: SDR_c; cd05233 1435356000721 NAD(P) binding site [chemical binding]; other site 1435356000722 active site 1435356000723 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1435356000724 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356000725 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1435356000726 active site 1435356000727 catalytic triad [active] 1435356000728 oxyanion hole [active] 1435356000729 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1435356000730 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1435356000731 active site 2 [active] 1435356000732 active site 1 [active] 1435356000733 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1435356000734 active site 2 [active] 1435356000735 active site 1 [active] 1435356000736 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1435356000737 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1435356000738 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 1435356000739 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356000740 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1435356000741 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1435356000742 FAD binding pocket [chemical binding]; other site 1435356000743 FAD binding motif [chemical binding]; other site 1435356000744 phosphate binding motif [ion binding]; other site 1435356000745 beta-alpha-beta structure motif; other site 1435356000746 NAD binding pocket [chemical binding]; other site 1435356000747 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1435356000748 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1435356000749 catalytic loop [active] 1435356000750 iron binding site [ion binding]; other site 1435356000751 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1435356000752 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1435356000753 putative di-iron ligands [ion binding]; other site 1435356000754 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1435356000755 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356000756 putative substrate translocation pore; other site 1435356000757 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 1435356000758 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1435356000759 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1435356000760 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1435356000761 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1435356000762 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1435356000763 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1435356000764 molybdopterin cofactor binding site; other site 1435356000765 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1435356000766 selenophosphate synthetase; Provisional; Region: PRK00943 1435356000767 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1435356000768 dimerization interface [polypeptide binding]; other site 1435356000769 putative ATP binding site [chemical binding]; other site 1435356000770 selenocysteine synthase; Provisional; Region: PRK04311 1435356000771 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 1435356000772 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1435356000773 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1435356000774 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 1435356000775 G1 box; other site 1435356000776 GTP/Mg2+ binding site [chemical binding]; other site 1435356000777 G2 box; other site 1435356000778 Switch I region; other site 1435356000779 G3 box; other site 1435356000780 Switch II region; other site 1435356000781 G4 box; other site 1435356000782 G5 box; other site 1435356000783 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 1435356000784 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 1435356000785 glutamate dehydrogenase; Provisional; Region: PRK09414 1435356000786 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1435356000787 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1435356000788 NAD(P) binding site [chemical binding]; other site 1435356000789 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1435356000790 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1435356000791 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1435356000792 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1435356000793 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1435356000794 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1435356000795 catalytic loop [active] 1435356000796 iron binding site [ion binding]; other site 1435356000797 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1435356000798 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 1435356000799 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 1435356000800 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1435356000801 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1435356000802 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1435356000803 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1435356000804 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 1435356000805 MoxR-like ATPases [General function prediction only]; Region: COG0714 1435356000806 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 1435356000807 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1435356000808 metal ion-dependent adhesion site (MIDAS); other site 1435356000809 Copper resistance protein D; Region: CopD; pfam05425 1435356000810 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1435356000811 Secretory lipase; Region: LIP; pfam03583 1435356000812 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1435356000813 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1435356000814 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1435356000815 Walker A/P-loop; other site 1435356000816 ATP binding site [chemical binding]; other site 1435356000817 Q-loop/lid; other site 1435356000818 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1435356000819 ABC transporter; Region: ABC_tran_2; pfam12848 1435356000820 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1435356000821 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1435356000822 active site 1435356000823 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 1435356000824 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1435356000825 active site 1435356000826 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1435356000827 active site 1435356000828 catalytic site [active] 1435356000829 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 1435356000830 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1435356000831 apolar tunnel; other site 1435356000832 heme binding site [chemical binding]; other site 1435356000833 dimerization interface [polypeptide binding]; other site 1435356000834 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1435356000835 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1435356000836 active site 1435356000837 Poxvirus protein I5; Region: Pox_I5; cl17286 1435356000838 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1435356000839 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1435356000840 Zn binding site [ion binding]; other site 1435356000841 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1435356000842 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1435356000843 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1435356000844 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1435356000845 catalytic residues [active] 1435356000846 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1435356000847 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1435356000848 Coenzyme A binding pocket [chemical binding]; other site 1435356000849 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1435356000850 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1435356000851 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 1435356000852 putative DNA binding site [nucleotide binding]; other site 1435356000853 catalytic residue [active] 1435356000854 putative H2TH interface [polypeptide binding]; other site 1435356000855 putative catalytic residues [active] 1435356000856 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1435356000857 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1435356000858 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1435356000859 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1435356000860 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1435356000861 NAD binding site [chemical binding]; other site 1435356000862 catalytic Zn binding site [ion binding]; other site 1435356000863 structural Zn binding site [ion binding]; other site 1435356000864 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1435356000865 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1435356000866 trigger factor; Provisional; Region: tig; PRK01490 1435356000867 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1435356000868 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1435356000869 Clp protease; Region: CLP_protease; pfam00574 1435356000870 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1435356000871 oligomer interface [polypeptide binding]; other site 1435356000872 active site residues [active] 1435356000873 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1435356000874 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1435356000875 oligomer interface [polypeptide binding]; other site 1435356000876 active site residues [active] 1435356000877 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1435356000878 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1435356000879 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1435356000880 Walker A motif; other site 1435356000881 ATP binding site [chemical binding]; other site 1435356000882 Walker B motif; other site 1435356000883 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1435356000884 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1435356000885 classical (c) SDRs; Region: SDR_c; cd05233 1435356000886 NAD(P) binding site [chemical binding]; other site 1435356000887 active site 1435356000888 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1435356000889 NAD(P) binding site [chemical binding]; other site 1435356000890 active site 1435356000891 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356000892 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356000893 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 1435356000894 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1435356000895 dimer interface [polypeptide binding]; other site 1435356000896 active site 1435356000897 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1435356000898 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1435356000899 Acyl-CoA dehydrogenase, C-terminal domain; Region: Acyl-CoA_dh_1; pfam00441 1435356000900 active site 1435356000901 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1435356000902 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1435356000903 active site 1435356000904 enoyl-CoA hydratase; Region: PLN02864 1435356000905 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 1435356000906 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 1435356000907 dimer interaction site [polypeptide binding]; other site 1435356000908 substrate-binding tunnel; other site 1435356000909 active site 1435356000910 catalytic site [active] 1435356000911 substrate binding site [chemical binding]; other site 1435356000912 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1435356000913 CoenzymeA binding site [chemical binding]; other site 1435356000914 subunit interaction site [polypeptide binding]; other site 1435356000915 PHB binding site; other site 1435356000916 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1435356000917 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1435356000918 Secretory lipase; Region: LIP; pfam03583 1435356000919 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1435356000920 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1435356000921 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1435356000922 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1435356000923 non-specific DNA binding site [nucleotide binding]; other site 1435356000924 salt bridge; other site 1435356000925 sequence-specific DNA binding site [nucleotide binding]; other site 1435356000926 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1435356000927 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1435356000928 HutD; Region: HutD; pfam05962 1435356000929 allantoate amidohydrolase; Reviewed; Region: PRK09290 1435356000930 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1435356000931 active site 1435356000932 metal binding site [ion binding]; metal-binding site 1435356000933 dimer interface [polypeptide binding]; other site 1435356000934 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1435356000935 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 1435356000936 active site 1435356000937 FMN binding site [chemical binding]; other site 1435356000938 substrate binding site [chemical binding]; other site 1435356000939 3Fe-4S cluster binding site [ion binding]; other site 1435356000940 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 1435356000941 domain_subunit interface; other site 1435356000942 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 1435356000943 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 1435356000944 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 1435356000945 active site 1435356000946 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 1435356000947 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1435356000948 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1435356000949 Acyl-CoA dehydrogenase, C-terminal domain; Region: Acyl-CoA_dh_1; pfam00441 1435356000950 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1435356000951 active site 1435356000952 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1435356000953 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1435356000954 Amidase; Region: Amidase; cl11426 1435356000955 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 1435356000956 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 1435356000957 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1435356000958 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1435356000959 FMN-binding pocket [chemical binding]; other site 1435356000960 flavin binding motif; other site 1435356000961 phosphate binding motif [ion binding]; other site 1435356000962 beta-alpha-beta structure motif; other site 1435356000963 NAD binding pocket [chemical binding]; other site 1435356000964 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1435356000965 catalytic loop [active] 1435356000966 iron binding site [ion binding]; other site 1435356000967 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 1435356000968 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 1435356000969 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1435356000970 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1435356000971 Coenzyme A binding pocket [chemical binding]; other site 1435356000972 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1435356000973 substrate binding site [chemical binding]; other site 1435356000974 dimer interface [polypeptide binding]; other site 1435356000975 ATP binding site [chemical binding]; other site 1435356000976 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1435356000977 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1435356000978 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1435356000979 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1435356000980 HIGH motif; other site 1435356000981 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1435356000982 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1435356000983 active site 1435356000984 KMSKS motif; other site 1435356000985 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1435356000986 tRNA binding surface [nucleotide binding]; other site 1435356000987 anticodon binding site; other site 1435356000988 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1435356000989 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 1435356000990 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1435356000991 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1435356000992 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 1435356000993 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1435356000994 active site 1435356000995 multimer interface [polypeptide binding]; other site 1435356000996 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1435356000997 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1435356000998 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1435356000999 homodimer interface [polypeptide binding]; other site 1435356001000 oligonucleotide binding site [chemical binding]; other site 1435356001001 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1435356001002 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1435356001003 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1435356001004 GTPase CgtA; Reviewed; Region: obgE; PRK12296 1435356001005 GTP1/OBG; Region: GTP1_OBG; pfam01018 1435356001006 Obg GTPase; Region: Obg; cd01898 1435356001007 G1 box; other site 1435356001008 GTP/Mg2+ binding site [chemical binding]; other site 1435356001009 Switch I region; other site 1435356001010 G2 box; other site 1435356001011 G3 box; other site 1435356001012 Switch II region; other site 1435356001013 G4 box; other site 1435356001014 G5 box; other site 1435356001015 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1435356001016 gamma-glutamyl kinase; Provisional; Region: PRK05429 1435356001017 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1435356001018 nucleotide binding site [chemical binding]; other site 1435356001019 homotetrameric interface [polypeptide binding]; other site 1435356001020 putative phosphate binding site [ion binding]; other site 1435356001021 putative allosteric binding site; other site 1435356001022 PUA domain; Region: PUA; pfam01472 1435356001023 NAD-dependent deacetylase; Provisional; Region: PRK00481 1435356001024 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1435356001025 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 1435356001026 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 1435356001027 active site 1435356001028 DNA binding site [nucleotide binding] 1435356001029 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 1435356001030 DNA binding site [nucleotide binding] 1435356001031 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 1435356001032 nucleotide binding site [chemical binding]; other site 1435356001033 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159 1435356001034 putative ligand binding site [chemical binding]; other site 1435356001035 putative NAD binding site [chemical binding]; other site 1435356001036 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1435356001037 catalytic site [active] 1435356001038 L-ectoine synthase; Reviewed; Region: ectC; PRK13290 1435356001039 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 1435356001040 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1435356001041 inhibitor-cofactor binding pocket; inhibition site 1435356001042 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1435356001043 catalytic residue [active] 1435356001044 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1435356001045 Coenzyme A binding pocket [chemical binding]; other site 1435356001046 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1435356001047 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1435356001048 ATP binding site [chemical binding]; other site 1435356001049 putative Mg++ binding site [ion binding]; other site 1435356001050 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1435356001051 nucleotide binding region [chemical binding]; other site 1435356001052 ATP-binding site [chemical binding]; other site 1435356001053 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1435356001054 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 1435356001055 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1435356001056 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1435356001057 thiamine monophosphate kinase; Provisional; Region: PRK05731 1435356001058 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1435356001059 ATP binding site [chemical binding]; other site 1435356001060 dimerization interface [polypeptide binding]; other site 1435356001061 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1435356001062 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1435356001063 trimer interface [polypeptide binding]; other site 1435356001064 putative metal binding site [ion binding]; other site 1435356001065 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1435356001066 ligand binding site [chemical binding]; other site 1435356001067 active site 1435356001068 UGI interface [polypeptide binding]; other site 1435356001069 catalytic site [active] 1435356001070 enoyl-CoA hydratase; Provisional; Region: PRK06688 1435356001071 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1435356001072 substrate binding site [chemical binding]; other site 1435356001073 oxyanion hole (OAH) forming residues; other site 1435356001074 trimer interface [polypeptide binding]; other site 1435356001075 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1435356001076 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1435356001077 DAK2 domain; Region: Dak2; pfam02734 1435356001078 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1435356001079 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1435356001080 generic binding surface II; other site 1435356001081 ssDNA binding site; other site 1435356001082 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1435356001083 ATP binding site [chemical binding]; other site 1435356001084 putative Mg++ binding site [ion binding]; other site 1435356001085 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1435356001086 nucleotide binding region [chemical binding]; other site 1435356001087 ATP-binding site [chemical binding]; other site 1435356001088 pyruvate carboxylase; Reviewed; Region: PRK12999 1435356001089 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1435356001090 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1435356001091 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1435356001092 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1435356001093 active site 1435356001094 catalytic residues [active] 1435356001095 metal binding site [ion binding]; metal-binding site 1435356001096 homodimer binding site [polypeptide binding]; other site 1435356001097 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1435356001098 carboxyltransferase (CT) interaction site; other site 1435356001099 biotinylation site [posttranslational modification]; other site 1435356001100 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1435356001101 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1435356001102 S-adenosylmethionine binding site [chemical binding]; other site 1435356001103 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1435356001104 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1435356001105 active site 1435356001106 (T/H)XGH motif; other site 1435356001107 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1435356001108 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1435356001109 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1435356001110 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1435356001111 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 1435356001112 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1435356001113 dimerization interface [polypeptide binding]; other site 1435356001114 active site 1435356001115 metal binding site [ion binding]; metal-binding site 1435356001116 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1435356001117 dsRNA binding site [nucleotide binding]; other site 1435356001118 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1435356001119 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1435356001120 DNA binding site [nucleotide binding] 1435356001121 catalytic residue [active] 1435356001122 H2TH interface [polypeptide binding]; other site 1435356001123 putative catalytic residues [active] 1435356001124 turnover-facilitating residue; other site 1435356001125 intercalation triad [nucleotide binding]; other site 1435356001126 8OG recognition residue [nucleotide binding]; other site 1435356001127 putative reading head residues; other site 1435356001128 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1435356001129 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1435356001130 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 1435356001131 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 1435356001132 heterodimer interface [polypeptide binding]; other site 1435356001133 active site 1435356001134 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1435356001135 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 1435356001136 active site 1435356001137 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1435356001138 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1435356001139 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1435356001140 dimerization interface [polypeptide binding]; other site 1435356001141 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 1435356001142 acylphosphatase; Provisional; Region: PRK14422 1435356001143 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1435356001144 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1435356001145 AAA domain; Region: AAA_23; pfam13476 1435356001146 Walker A/P-loop; other site 1435356001147 ATP binding site [chemical binding]; other site 1435356001148 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 1435356001149 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1435356001150 ABC transporter signature motif; other site 1435356001151 Walker B; other site 1435356001152 D-loop; other site 1435356001153 H-loop/switch region; other site 1435356001154 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1435356001155 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 1435356001156 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1435356001157 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1435356001158 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1435356001159 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1435356001160 PII uridylyl-transferase; Provisional; Region: PRK03381 1435356001161 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1435356001162 metal binding triad; other site 1435356001163 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1435356001164 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 1435356001165 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 1435356001166 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 1435356001167 signal recognition particle protein; Provisional; Region: PRK10867 1435356001168 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1435356001169 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1435356001170 P loop; other site 1435356001171 GTP binding site [chemical binding]; other site 1435356001172 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1435356001173 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 1435356001174 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 1435356001175 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1435356001176 G-X-X-G motif; other site 1435356001177 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1435356001178 RimM N-terminal domain; Region: RimM; pfam01782 1435356001179 PRC-barrel domain; Region: PRC; pfam05239 1435356001180 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1435356001181 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1435356001182 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1435356001183 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1435356001184 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1435356001185 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1435356001186 RNA binding site [nucleotide binding]; other site 1435356001187 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1435356001188 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1435356001189 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1435356001190 Catalytic site [active] 1435356001191 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1435356001192 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1435356001193 RNA/DNA hybrid binding site [nucleotide binding]; other site 1435356001194 active site 1435356001195 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 1435356001196 hypothetical protein; Reviewed; Region: PRK12497 1435356001197 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1435356001198 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1435356001199 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1435356001200 Walker A motif; other site 1435356001201 ATP binding site [chemical binding]; other site 1435356001202 Walker B motif; other site 1435356001203 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1435356001204 DNA protecting protein DprA; Region: dprA; TIGR00732 1435356001205 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1435356001206 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1435356001207 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1435356001208 Cl- selectivity filter; other site 1435356001209 Cl- binding residues [ion binding]; other site 1435356001210 pore gating glutamate residue; other site 1435356001211 dimer interface [polypeptide binding]; other site 1435356001212 H+/Cl- coupling transport residue; other site 1435356001213 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1435356001214 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1435356001215 FAD binding pocket [chemical binding]; other site 1435356001216 FAD binding motif [chemical binding]; other site 1435356001217 phosphate binding motif [ion binding]; other site 1435356001218 NAD binding pocket [chemical binding]; other site 1435356001219 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1435356001220 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356001221 putative substrate translocation pore; other site 1435356001222 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1435356001223 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1435356001224 active site 1435356001225 DNA binding site [nucleotide binding] 1435356001226 Int/Topo IB signature motif; other site 1435356001227 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1435356001228 Peptidase family M23; Region: Peptidase_M23; pfam01551 1435356001229 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1435356001230 rRNA interaction site [nucleotide binding]; other site 1435356001231 S8 interaction site; other site 1435356001232 putative laminin-1 binding site; other site 1435356001233 elongation factor Ts; Provisional; Region: tsf; PRK09377 1435356001234 Elongation factor TS; Region: EF_TS; pfam00889 1435356001235 Elongation factor TS; Region: EF_TS; pfam00889 1435356001236 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1435356001237 putative nucleotide binding site [chemical binding]; other site 1435356001238 uridine monophosphate binding site [chemical binding]; other site 1435356001239 homohexameric interface [polypeptide binding]; other site 1435356001240 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1435356001241 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1435356001242 hinge region; other site 1435356001243 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1435356001244 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1435356001245 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1435356001246 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1435356001247 S-adenosylmethionine binding site [chemical binding]; other site 1435356001248 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1435356001249 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 1435356001250 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1435356001251 FeS/SAM binding site; other site 1435356001252 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 1435356001253 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1435356001254 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1435356001255 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1435356001256 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1435356001257 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1435356001258 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1435356001259 active site 1435356001260 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1435356001261 protein binding site [polypeptide binding]; other site 1435356001262 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1435356001263 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1435356001264 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1435356001265 Predicted acetyltransferase [General function prediction only]; Region: COG3393 1435356001266 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 1435356001267 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1435356001268 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1435356001269 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1435356001270 amino acid transporter; Region: 2A0306; TIGR00909 1435356001271 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1435356001272 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1435356001273 DNA binding residues [nucleotide binding] 1435356001274 dimerization interface [polypeptide binding]; other site 1435356001275 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1435356001276 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1435356001277 acyl-activating enzyme (AAE) consensus motif; other site 1435356001278 AMP binding site [chemical binding]; other site 1435356001279 active site 1435356001280 CoA binding site [chemical binding]; other site 1435356001281 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1435356001282 active site 1435356001283 mycothione reductase; Reviewed; Region: PRK07846 1435356001284 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1435356001285 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1435356001286 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1435356001287 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1435356001288 malate:quinone oxidoreductase; Validated; Region: PRK05257 1435356001289 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1435356001290 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1435356001291 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1435356001292 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1435356001293 homodimer interface [polypeptide binding]; other site 1435356001294 active site 1435356001295 SAM binding site [chemical binding]; other site 1435356001296 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1435356001297 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356001298 putative substrate translocation pore; other site 1435356001299 hypothetical protein; Validated; Region: PRK02101 1435356001300 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1435356001301 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1435356001302 dimer interface [polypeptide binding]; other site 1435356001303 motif 1; other site 1435356001304 active site 1435356001305 motif 2; other site 1435356001306 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1435356001307 putative deacylase active site [active] 1435356001308 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1435356001309 active site 1435356001310 motif 3; other site 1435356001311 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1435356001312 anticodon binding site; other site 1435356001313 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1435356001314 Sm and related proteins; Region: Sm_like; cl00259 1435356001315 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1435356001316 putative oligomer interface [polypeptide binding]; other site 1435356001317 putative RNA binding site [nucleotide binding]; other site 1435356001318 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1435356001319 NusA N-terminal domain; Region: NusA_N; pfam08529 1435356001320 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1435356001321 RNA binding site [nucleotide binding]; other site 1435356001322 homodimer interface [polypeptide binding]; other site 1435356001323 NusA-like KH domain; Region: KH_5; pfam13184 1435356001324 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1435356001325 G-X-X-G motif; other site 1435356001326 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1435356001327 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1435356001328 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 1435356001329 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1435356001330 G1 box; other site 1435356001331 putative GEF interaction site [polypeptide binding]; other site 1435356001332 GTP/Mg2+ binding site [chemical binding]; other site 1435356001333 Switch I region; other site 1435356001334 G2 box; other site 1435356001335 G3 box; other site 1435356001336 Switch II region; other site 1435356001337 G4 box; other site 1435356001338 G5 box; other site 1435356001339 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1435356001340 Translation-initiation factor 2; Region: IF-2; pfam11987 1435356001341 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1435356001342 Protein of unknown function (DUF503); Region: DUF503; pfam04456 1435356001343 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1435356001344 DHH family; Region: DHH; pfam01368 1435356001345 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1435356001346 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1435356001347 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1435356001348 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1435356001349 active site 1435356001350 metal binding site [ion binding]; metal-binding site 1435356001351 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 1435356001352 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1435356001353 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 1435356001354 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1435356001355 RNA binding site [nucleotide binding]; other site 1435356001356 active site 1435356001357 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 1435356001358 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1435356001359 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1435356001360 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1435356001361 FeoA domain; Region: FeoA; pfam04023 1435356001362 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1435356001363 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1435356001364 ABC-ATPase subunit interface; other site 1435356001365 dimer interface [polypeptide binding]; other site 1435356001366 putative PBP binding regions; other site 1435356001367 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1435356001368 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1435356001369 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1435356001370 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1435356001371 metal binding site [ion binding]; metal-binding site 1435356001372 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1435356001373 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1435356001374 active site 1435356001375 Riboflavin kinase; Region: Flavokinase; smart00904 1435356001376 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1435356001377 16S/18S rRNA binding site [nucleotide binding]; other site 1435356001378 S13e-L30e interaction site [polypeptide binding]; other site 1435356001379 25S rRNA binding site [nucleotide binding]; other site 1435356001380 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 1435356001381 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1435356001382 oligomer interface [polypeptide binding]; other site 1435356001383 RNA binding site [nucleotide binding]; other site 1435356001384 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1435356001385 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1435356001386 RNase E interface [polypeptide binding]; other site 1435356001387 trimer interface [polypeptide binding]; other site 1435356001388 active site 1435356001389 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1435356001390 putative nucleic acid binding region [nucleotide binding]; other site 1435356001391 G-X-X-G motif; other site 1435356001392 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1435356001393 RNA binding site [nucleotide binding]; other site 1435356001394 domain interface; other site 1435356001395 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1435356001396 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356001397 putative substrate translocation pore; other site 1435356001398 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1435356001399 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1435356001400 [4Fe-4S] binding site [ion binding]; other site 1435356001401 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1435356001402 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1435356001403 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1435356001404 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1435356001405 molybdopterin cofactor binding site; other site 1435356001406 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1435356001407 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 1435356001408 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1435356001409 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1435356001410 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1435356001411 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1435356001412 Predicted ATPase [General function prediction only]; Region: COG1485 1435356001413 AAA domain; Region: AAA_14; pfam13173 1435356001414 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1435356001415 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1435356001416 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1435356001417 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1435356001418 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1435356001419 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1435356001420 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1435356001421 putative hydrophobic ligand binding site [chemical binding]; other site 1435356001422 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 1435356001423 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 1435356001424 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1435356001425 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1435356001426 dimer interface [polypeptide binding]; other site 1435356001427 active site 1435356001428 catalytic residue [active] 1435356001429 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1435356001430 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1435356001431 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1435356001432 TIGR03085 family protein; Region: TIGR03085 1435356001433 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1435356001434 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1435356001435 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1435356001436 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1435356001437 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1435356001438 YCII-related domain; Region: YCII; cl00999 1435356001439 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1435356001440 Coenzyme A binding pocket [chemical binding]; other site 1435356001441 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1435356001442 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1435356001443 non-specific DNA binding site [nucleotide binding]; other site 1435356001444 salt bridge; other site 1435356001445 sequence-specific DNA binding site [nucleotide binding]; other site 1435356001446 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1435356001447 Cobalt transport protein; Region: CbiQ; cl00463 1435356001448 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1435356001449 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1435356001450 Walker A/P-loop; other site 1435356001451 ATP binding site [chemical binding]; other site 1435356001452 Q-loop/lid; other site 1435356001453 ABC transporter signature motif; other site 1435356001454 Walker B; other site 1435356001455 D-loop; other site 1435356001456 H-loop/switch region; other site 1435356001457 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 1435356001458 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1435356001459 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1435356001460 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1435356001461 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1435356001462 recombinase A; Provisional; Region: recA; PRK09354 1435356001463 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1435356001464 hexamer interface [polypeptide binding]; other site 1435356001465 Walker A motif; other site 1435356001466 ATP binding site [chemical binding]; other site 1435356001467 Walker B motif; other site 1435356001468 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1435356001469 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1435356001470 dimer interface [polypeptide binding]; other site 1435356001471 conserved gate region; other site 1435356001472 putative PBP binding loops; other site 1435356001473 ABC-ATPase subunit interface; other site 1435356001474 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1435356001475 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1435356001476 dimer interface [polypeptide binding]; other site 1435356001477 conserved gate region; other site 1435356001478 putative PBP binding loops; other site 1435356001479 ABC-ATPase subunit interface; other site 1435356001480 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1435356001481 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1435356001482 substrate binding pocket [chemical binding]; other site 1435356001483 membrane-bound complex binding site; other site 1435356001484 hinge residues; other site 1435356001485 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1435356001486 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1435356001487 Walker A/P-loop; other site 1435356001488 ATP binding site [chemical binding]; other site 1435356001489 Q-loop/lid; other site 1435356001490 ABC transporter signature motif; other site 1435356001491 Walker B; other site 1435356001492 D-loop; other site 1435356001493 H-loop/switch region; other site 1435356001494 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 1435356001495 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1435356001496 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1435356001497 FeS/SAM binding site; other site 1435356001498 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1435356001499 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1435356001500 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1435356001501 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 1435356001502 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1435356001503 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1435356001504 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1435356001505 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1435356001506 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1435356001507 GTPases [General function prediction only]; Region: HflX; COG2262 1435356001508 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1435356001509 HflX GTPase family; Region: HflX; cd01878 1435356001510 G1 box; other site 1435356001511 GTP/Mg2+ binding site [chemical binding]; other site 1435356001512 Switch I region; other site 1435356001513 G2 box; other site 1435356001514 G3 box; other site 1435356001515 Switch II region; other site 1435356001516 G4 box; other site 1435356001517 G5 box; other site 1435356001518 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1435356001519 dimerization domain swap beta strand [polypeptide binding]; other site 1435356001520 regulatory protein interface [polypeptide binding]; other site 1435356001521 active site 1435356001522 regulatory phosphorylation site [posttranslational modification]; other site 1435356001523 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1435356001524 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1435356001525 active site 1435356001526 phosphorylation site [posttranslational modification] 1435356001527 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1435356001528 active site 1435356001529 P-loop; other site 1435356001530 phosphorylation site [posttranslational modification] 1435356001531 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1435356001532 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1435356001533 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1435356001534 putative substrate binding site [chemical binding]; other site 1435356001535 putative ATP binding site [chemical binding]; other site 1435356001536 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1435356001537 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1435356001538 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1435356001539 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1435356001540 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1435356001541 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1435356001542 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1435356001543 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 1435356001544 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1435356001545 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1435356001546 active site 1435356001547 LexA repressor; Validated; Region: PRK00215 1435356001548 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1435356001549 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1435356001550 Catalytic site [active] 1435356001551 LysM domain; Region: LysM; pfam01476 1435356001552 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1435356001553 ATP cone domain; Region: ATP-cone; pfam03477 1435356001554 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 1435356001555 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1435356001556 ATP binding site [chemical binding]; other site 1435356001557 putative Mg++ binding site [ion binding]; other site 1435356001558 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1435356001559 nucleotide binding region [chemical binding]; other site 1435356001560 ATP-binding site [chemical binding]; other site 1435356001561 Helicase associated domain (HA2); Region: HA2; pfam04408 1435356001562 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1435356001563 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1435356001564 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 1435356001565 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1435356001566 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 1435356001567 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1435356001568 inhibitor-cofactor binding pocket; inhibition site 1435356001569 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1435356001570 catalytic residue [active] 1435356001571 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1435356001572 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1435356001573 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1435356001574 dimerization interface [polypeptide binding]; other site 1435356001575 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1435356001576 dimerization interface [polypeptide binding]; other site 1435356001577 substrate binding pocket [chemical binding]; other site 1435356001578 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1435356001579 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1435356001580 ATP binding site [chemical binding]; other site 1435356001581 putative Mg++ binding site [ion binding]; other site 1435356001582 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1435356001583 nucleotide binding region [chemical binding]; other site 1435356001584 ATP-binding site [chemical binding]; other site 1435356001585 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 1435356001586 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1435356001587 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1435356001588 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1435356001589 PAC2 family; Region: PAC2; pfam09754 1435356001590 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 1435356001591 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1435356001592 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1435356001593 NAD binding site [chemical binding]; other site 1435356001594 homodimer interface [polypeptide binding]; other site 1435356001595 active site 1435356001596 substrate binding site [chemical binding]; other site 1435356001597 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1435356001598 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1435356001599 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1435356001600 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 1435356001601 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 1435356001602 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1435356001603 active site 1435356001604 Zn binding site [ion binding]; other site 1435356001605 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1435356001606 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1435356001607 Coenzyme A binding pocket [chemical binding]; other site 1435356001608 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 1435356001609 CoA binding domain; Region: CoA_binding_2; pfam13380 1435356001610 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1435356001611 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1435356001612 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1435356001613 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1435356001614 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1435356001615 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1435356001616 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1435356001617 DNA binding residues [nucleotide binding] 1435356001618 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 1435356001619 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1435356001620 S-adenosylmethionine binding site [chemical binding]; other site 1435356001621 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 1435356001622 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 1435356001623 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 1435356001624 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1435356001625 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1435356001626 ATP binding site [chemical binding]; other site 1435356001627 putative Mg++ binding site [ion binding]; other site 1435356001628 Protein of unknown function (DUF952); Region: DUF952; cl01393 1435356001629 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1435356001630 TrkA-C domain; Region: TrkA_C; pfam02080 1435356001631 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1435356001632 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1435356001633 D-allose transporter subunit; Provisional; Region: PRK09701 1435356001634 Phage capsid family; Region: Phage_capsid; pfam05065 1435356001635 Phage terminase, small subunit; Region: Terminase_4; pfam05119 1435356001636 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1435356001637 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1435356001638 active site 1435356001639 AAA domain; Region: AAA_25; pfam13481 1435356001640 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1435356001641 Walker A motif; other site 1435356001642 ATP binding site [chemical binding]; other site 1435356001643 Walker B motif; other site 1435356001644 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1435356001645 active site 1435356001646 Int/Topo IB signature motif; other site 1435356001647 DNA binding site [nucleotide binding] 1435356001648 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1435356001649 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1435356001650 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1435356001651 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1435356001652 DNA binding residues [nucleotide binding] 1435356001653 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1435356001654 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1435356001655 nucleotide binding site [chemical binding]; other site 1435356001656 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1435356001657 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1435356001658 active site 1435356001659 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1435356001660 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1435356001661 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 1435356001662 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1435356001663 trimer interface [polypeptide binding]; other site 1435356001664 active site 1435356001665 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 1435356001666 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1435356001667 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1435356001668 generic binding surface I; other site 1435356001669 generic binding surface II; other site 1435356001670 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 1435356001671 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1435356001672 TrkA-N domain; Region: TrkA_N; pfam02254 1435356001673 TrkA-C domain; Region: TrkA_C; pfam02080 1435356001674 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1435356001675 TrkA-N domain; Region: TrkA_N; pfam02254 1435356001676 TrkA-C domain; Region: TrkA_C; pfam02080 1435356001677 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1435356001678 TRAM domain; Region: TRAM; pfam01938 1435356001679 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1435356001680 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1435356001681 S-adenosylmethionine binding site [chemical binding]; other site 1435356001682 MarR family; Region: MarR_2; pfam12802 1435356001683 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1435356001684 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1435356001685 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356001686 putative substrate translocation pore; other site 1435356001687 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1435356001688 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1435356001689 TPP-binding site; other site 1435356001690 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1435356001691 PYR/PP interface [polypeptide binding]; other site 1435356001692 dimer interface [polypeptide binding]; other site 1435356001693 TPP binding site [chemical binding]; other site 1435356001694 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1435356001695 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 1435356001696 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356001697 putative substrate translocation pore; other site 1435356001698 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356001699 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1435356001700 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1435356001701 catalytic site [active] 1435356001702 putative active site [active] 1435356001703 putative substrate binding site [chemical binding]; other site 1435356001704 Helicase and RNase D C-terminal; Region: HRDC; smart00341 1435356001705 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1435356001706 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1435356001707 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 1435356001708 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 1435356001709 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1435356001710 substrate binding site [chemical binding]; other site 1435356001711 active site 1435356001712 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1435356001713 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1435356001714 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 1435356001715 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1435356001716 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1435356001717 molybdopterin cofactor binding site [chemical binding]; other site 1435356001718 substrate binding site [chemical binding]; other site 1435356001719 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1435356001720 molybdopterin cofactor binding site; other site 1435356001721 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 1435356001722 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1435356001723 NAD(P) binding site [chemical binding]; other site 1435356001724 LDH/MDH dimer interface [polypeptide binding]; other site 1435356001725 substrate binding site [chemical binding]; other site 1435356001726 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1435356001727 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1435356001728 motif II; other site 1435356001729 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1435356001730 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 1435356001731 SelR domain; Region: SelR; pfam01641 1435356001732 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1435356001733 TAP-like protein; Region: Abhydrolase_4; pfam08386 1435356001734 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 1435356001735 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1435356001736 Walker A motif; other site 1435356001737 ATP binding site [chemical binding]; other site 1435356001738 Walker B motif; other site 1435356001739 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1435356001740 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1435356001741 Coenzyme A binding pocket [chemical binding]; other site 1435356001742 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1435356001743 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1435356001744 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1435356001745 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1435356001746 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1435356001747 active site 1435356001748 dimer interface [polypeptide binding]; other site 1435356001749 motif 1; other site 1435356001750 motif 2; other site 1435356001751 motif 3; other site 1435356001752 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1435356001753 anticodon binding site; other site 1435356001754 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 1435356001755 nucleotide binding site/active site [active] 1435356001756 HIT family signature motif; other site 1435356001757 catalytic residue [active] 1435356001758 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1435356001759 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1435356001760 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1435356001761 putative acyl-acceptor binding pocket; other site 1435356001762 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1435356001763 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1435356001764 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1435356001765 nudix motif; other site 1435356001766 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1435356001767 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1435356001768 active site 1435356001769 multimer interface [polypeptide binding]; other site 1435356001770 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1435356001771 PAS domain; Region: PAS_9; pfam13426 1435356001772 putative active site [active] 1435356001773 heme pocket [chemical binding]; other site 1435356001774 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1435356001775 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1435356001776 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1435356001777 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1435356001778 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1435356001779 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1435356001780 active site 1435356001781 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1435356001782 catalytic triad [active] 1435356001783 dimer interface [polypeptide binding]; other site 1435356001784 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1435356001785 predicted active site [active] 1435356001786 catalytic triad [active] 1435356001787 hypothetical protein; Validated; Region: PRK00110 1435356001788 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 1435356001789 active site 1435356001790 putative DNA-binding cleft [nucleotide binding]; other site 1435356001791 dimer interface [polypeptide binding]; other site 1435356001792 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1435356001793 RuvA N terminal domain; Region: RuvA_N; pfam01330 1435356001794 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1435356001795 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1435356001796 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1435356001797 Walker A motif; other site 1435356001798 ATP binding site [chemical binding]; other site 1435356001799 Walker B motif; other site 1435356001800 arginine finger; other site 1435356001801 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1435356001802 Preprotein translocase subunit; Region: YajC; cl00806 1435356001803 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1435356001804 Protein export membrane protein; Region: SecD_SecF; cl14618 1435356001805 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1435356001806 Protein export membrane protein; Region: SecD_SecF; pfam02355 1435356001807 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1435356001808 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1435356001809 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1435356001810 active site 1435356001811 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 1435356001812 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 1435356001813 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1435356001814 Zn2+ binding site [ion binding]; other site 1435356001815 Mg2+ binding site [ion binding]; other site 1435356001816 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1435356001817 synthetase active site [active] 1435356001818 NTP binding site [chemical binding]; other site 1435356001819 metal binding site [ion binding]; metal-binding site 1435356001820 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1435356001821 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1435356001822 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1435356001823 active site 1435356001824 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1435356001825 active site 1435356001826 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1435356001827 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1435356001828 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1435356001829 dimer interface [polypeptide binding]; other site 1435356001830 motif 1; other site 1435356001831 active site 1435356001832 motif 2; other site 1435356001833 motif 3; other site 1435356001834 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1435356001835 anticodon binding site; other site 1435356001836 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1435356001837 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1435356001838 FeS/SAM binding site; other site 1435356001839 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1435356001840 active site 1435356001841 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1435356001842 MarR family; Region: MarR; pfam01047 1435356001843 Pirin-related protein [General function prediction only]; Region: COG1741 1435356001844 Pirin; Region: Pirin; pfam02678 1435356001845 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1435356001846 Pirin-related protein [General function prediction only]; Region: COG1741 1435356001847 Pirin; Region: Pirin; pfam02678 1435356001848 Domain of unknown function DUF21; Region: DUF21; pfam01595 1435356001849 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1435356001850 FOG: CBS domain [General function prediction only]; Region: COG0517 1435356001851 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1435356001852 Domain of unknown function DUF21; Region: DUF21; pfam01595 1435356001853 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1435356001854 Transporter associated domain; Region: CorC_HlyC; pfam03471 1435356001855 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 1435356001856 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1435356001857 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1435356001858 ATP binding site [chemical binding]; other site 1435356001859 putative Mg++ binding site [ion binding]; other site 1435356001860 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1435356001861 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1435356001862 nucleotide binding region [chemical binding]; other site 1435356001863 ATP-binding site [chemical binding]; other site 1435356001864 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1435356001865 classical (c) SDRs; Region: SDR_c; cd05233 1435356001866 NAD(P) binding site [chemical binding]; other site 1435356001867 active site 1435356001868 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1435356001869 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 1435356001870 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1435356001871 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1435356001872 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1435356001873 dimer interface [polypeptide binding]; other site 1435356001874 anticodon binding site; other site 1435356001875 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1435356001876 homodimer interface [polypeptide binding]; other site 1435356001877 motif 1; other site 1435356001878 active site 1435356001879 motif 2; other site 1435356001880 GAD domain; Region: GAD; pfam02938 1435356001881 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1435356001882 active site 1435356001883 motif 3; other site 1435356001884 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 1435356001885 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1435356001886 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1435356001887 PhoD-like phosphatase; Region: PhoD; pfam09423 1435356001888 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1435356001889 putative active site [active] 1435356001890 putative metal binding site [ion binding]; other site 1435356001891 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1435356001892 recombination factor protein RarA; Reviewed; Region: PRK13342 1435356001893 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1435356001894 Walker A motif; other site 1435356001895 ATP binding site [chemical binding]; other site 1435356001896 Walker B motif; other site 1435356001897 arginine finger; other site 1435356001898 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1435356001899 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1435356001900 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1435356001901 motif 1; other site 1435356001902 active site 1435356001903 motif 2; other site 1435356001904 motif 3; other site 1435356001905 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1435356001906 DHHA1 domain; Region: DHHA1; pfam02272 1435356001907 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 1435356001908 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 1435356001909 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 1435356001910 dimerization interface [polypeptide binding]; other site 1435356001911 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1435356001912 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1435356001913 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1435356001914 shikimate binding site; other site 1435356001915 NAD(P) binding site [chemical binding]; other site 1435356001916 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1435356001917 active site 1435356001918 YCII-related domain; Region: YCII; cl00999 1435356001919 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1435356001920 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 1435356001921 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1435356001922 chorismate synthase; Validated; Region: PRK05382 1435356001923 Tetramer interface [polypeptide binding]; other site 1435356001924 active site 1435356001925 FMN-binding site [chemical binding]; other site 1435356001926 shikimate kinase; Reviewed; Region: aroK; PRK00131 1435356001927 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1435356001928 ADP binding site [chemical binding]; other site 1435356001929 magnesium binding site [ion binding]; other site 1435356001930 putative shikimate binding site; other site 1435356001931 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1435356001932 active site 1435356001933 dimer interface [polypeptide binding]; other site 1435356001934 metal binding site [ion binding]; metal-binding site 1435356001935 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1435356001936 TIGR03086 family protein; Region: TIGR03086 1435356001937 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1435356001938 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1435356001939 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 1435356001940 active site 1435356001941 elongation factor P; Validated; Region: PRK00529 1435356001942 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1435356001943 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1435356001944 RNA binding site [nucleotide binding]; other site 1435356001945 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1435356001946 RNA binding site [nucleotide binding]; other site 1435356001947 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 1435356001948 putative RNA binding site [nucleotide binding]; other site 1435356001949 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1435356001950 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1435356001951 active site 1435356001952 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1435356001953 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1435356001954 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1435356001955 dihydroorotase; Validated; Region: pyrC; PRK09357 1435356001956 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1435356001957 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1435356001958 active site 1435356001959 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1435356001960 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1435356001961 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1435356001962 catalytic site [active] 1435356001963 subunit interface [polypeptide binding]; other site 1435356001964 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1435356001965 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1435356001966 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1435356001967 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1435356001968 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1435356001969 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1435356001970 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1435356001971 IMP binding site; other site 1435356001972 dimer interface [polypeptide binding]; other site 1435356001973 interdomain contacts; other site 1435356001974 partial ornithine binding site; other site 1435356001975 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1435356001976 active site 1435356001977 dimer interface [polypeptide binding]; other site 1435356001978 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1435356001979 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1435356001980 catalytic site [active] 1435356001981 G-X2-G-X-G-K; other site 1435356001982 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1435356001983 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1435356001984 Flavoprotein; Region: Flavoprotein; pfam02441 1435356001985 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1435356001986 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1435356001987 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1435356001988 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1435356001989 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1435356001990 primosome assembly protein PriA; Provisional; Region: PRK14873 1435356001991 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1435356001992 Lipase (class 2); Region: Lipase_2; pfam01674 1435356001993 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1435356001994 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1435356001995 putative active site [active] 1435356001996 substrate binding site [chemical binding]; other site 1435356001997 putative cosubstrate binding site; other site 1435356001998 catalytic site [active] 1435356001999 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1435356002000 substrate binding site [chemical binding]; other site 1435356002001 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1435356002002 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1435356002003 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 1435356002004 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1435356002005 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1435356002006 dimerization interface [polypeptide binding]; other site 1435356002007 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1435356002008 dimer interface [polypeptide binding]; other site 1435356002009 phosphorylation site [posttranslational modification] 1435356002010 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1435356002011 ATP binding site [chemical binding]; other site 1435356002012 Mg2+ binding site [ion binding]; other site 1435356002013 G-X-G motif; other site 1435356002014 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1435356002015 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1435356002016 active site 1435356002017 phosphorylation site [posttranslational modification] 1435356002018 intermolecular recognition site; other site 1435356002019 dimerization interface [polypeptide binding]; other site 1435356002020 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1435356002021 DNA binding site [nucleotide binding] 1435356002022 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1435356002023 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1435356002024 transmembrane helices; other site 1435356002025 Glycerate kinase family; Region: Gly_kinase; cl00841 1435356002026 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1435356002027 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1435356002028 putative substrate binding site [chemical binding]; other site 1435356002029 putative ATP binding site [chemical binding]; other site 1435356002030 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 1435356002031 putative dimer interface [polypeptide binding]; other site 1435356002032 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1435356002033 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1435356002034 substrate binding site [chemical binding]; other site 1435356002035 hexamer interface [polypeptide binding]; other site 1435356002036 metal binding site [ion binding]; metal-binding site 1435356002037 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1435356002038 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1435356002039 catalytic motif [active] 1435356002040 Zn binding site [ion binding]; other site 1435356002041 RibD C-terminal domain; Region: RibD_C; pfam01872 1435356002042 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1435356002043 Lumazine binding domain; Region: Lum_binding; pfam00677 1435356002044 Lumazine binding domain; Region: Lum_binding; pfam00677 1435356002045 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1435356002046 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1435356002047 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1435356002048 dimerization interface [polypeptide binding]; other site 1435356002049 active site 1435356002050 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1435356002051 homopentamer interface [polypeptide binding]; other site 1435356002052 active site 1435356002053 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1435356002054 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1435356002055 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1435356002056 GIY-YIG motif/motif A; other site 1435356002057 active site 1435356002058 catalytic site [active] 1435356002059 putative DNA binding site [nucleotide binding]; other site 1435356002060 metal binding site [ion binding]; metal-binding site 1435356002061 UvrB/uvrC motif; Region: UVR; pfam02151 1435356002062 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1435356002063 minor groove reading motif; other site 1435356002064 Helix-hairpin-helix motif; Region: HHH; pfam00633 1435356002065 helix-hairpin-helix signature motif; other site 1435356002066 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1435356002067 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1435356002068 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1435356002069 phosphate binding site [ion binding]; other site 1435356002070 putative substrate binding pocket [chemical binding]; other site 1435356002071 dimer interface [polypeptide binding]; other site 1435356002072 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1435356002073 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1435356002074 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1435356002075 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1435356002076 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1435356002077 Phosphoglycerate kinase; Region: PGK; pfam00162 1435356002078 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1435356002079 substrate binding site [chemical binding]; other site 1435356002080 hinge regions; other site 1435356002081 ADP binding site [chemical binding]; other site 1435356002082 catalytic site [active] 1435356002083 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1435356002084 triosephosphate isomerase; Provisional; Region: PRK14567 1435356002085 substrate binding site [chemical binding]; other site 1435356002086 dimer interface [polypeptide binding]; other site 1435356002087 catalytic triad [active] 1435356002088 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1435356002089 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1435356002090 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 1435356002091 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1435356002092 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1435356002093 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 1435356002094 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1435356002095 hydrophobic ligand binding site; other site 1435356002096 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1435356002097 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1435356002098 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1435356002099 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1435356002100 putative active site [active] 1435356002101 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 1435356002102 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 1435356002103 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1435356002104 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1435356002105 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1435356002106 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1435356002107 putative active site [active] 1435356002108 transaldolase; Provisional; Region: PRK03903 1435356002109 catalytic residue [active] 1435356002110 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1435356002111 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1435356002112 TPP-binding site [chemical binding]; other site 1435356002113 dimer interface [polypeptide binding]; other site 1435356002114 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1435356002115 PYR/PP interface [polypeptide binding]; other site 1435356002116 dimer interface [polypeptide binding]; other site 1435356002117 TPP binding site [chemical binding]; other site 1435356002118 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1435356002119 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1435356002120 UbiA prenyltransferase family; Region: UbiA; pfam01040 1435356002121 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1435356002122 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1435356002123 NADP binding site [chemical binding]; other site 1435356002124 dimer interface [polypeptide binding]; other site 1435356002125 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1435356002126 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1435356002127 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1435356002128 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1435356002129 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1435356002130 Walker A/P-loop; other site 1435356002131 ATP binding site [chemical binding]; other site 1435356002132 Q-loop/lid; other site 1435356002133 ABC transporter signature motif; other site 1435356002134 Walker B; other site 1435356002135 D-loop; other site 1435356002136 H-loop/switch region; other site 1435356002137 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1435356002138 Predicted transcriptional regulator [Transcription]; Region: COG2345 1435356002139 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1435356002140 putative DNA binding site [nucleotide binding]; other site 1435356002141 putative Zn2+ binding site [ion binding]; other site 1435356002142 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1435356002143 FeS assembly protein SufB; Region: sufB; TIGR01980 1435356002144 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1435356002145 FeS assembly protein SufD; Region: sufD; TIGR01981 1435356002146 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1435356002147 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1435356002148 Walker A/P-loop; other site 1435356002149 ATP binding site [chemical binding]; other site 1435356002150 Q-loop/lid; other site 1435356002151 ABC transporter signature motif; other site 1435356002152 Walker B; other site 1435356002153 D-loop; other site 1435356002154 H-loop/switch region; other site 1435356002155 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1435356002156 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1435356002157 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1435356002158 catalytic residue [active] 1435356002159 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1435356002160 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1435356002161 trimerization site [polypeptide binding]; other site 1435356002162 active site 1435356002163 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1435356002164 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1435356002165 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1435356002166 putative DNA binding site [nucleotide binding]; other site 1435356002167 putative homodimer interface [polypeptide binding]; other site 1435356002168 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 1435356002169 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1435356002170 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1435356002171 Walker A/P-loop; other site 1435356002172 ATP binding site [chemical binding]; other site 1435356002173 Q-loop/lid; other site 1435356002174 ABC transporter signature motif; other site 1435356002175 Walker B; other site 1435356002176 D-loop; other site 1435356002177 H-loop/switch region; other site 1435356002178 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1435356002179 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356002180 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356002181 aconitate hydratase; Validated; Region: PRK09277 1435356002182 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1435356002183 substrate binding site [chemical binding]; other site 1435356002184 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1435356002185 ligand binding site [chemical binding]; other site 1435356002186 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1435356002187 substrate binding site [chemical binding]; other site 1435356002188 Glycoside hydrolase families 71, 99, and related domains; Region: GH99_GH71_like; cl01529 1435356002189 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1435356002190 NlpC/P60 family; Region: NLPC_P60; pfam00877 1435356002191 MoxR-like ATPases [General function prediction only]; Region: COG0714 1435356002192 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1435356002193 Walker A motif; other site 1435356002194 ATP binding site [chemical binding]; other site 1435356002195 Walker B motif; other site 1435356002196 arginine finger; other site 1435356002197 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1435356002198 Protein of unknown function DUF58; Region: DUF58; pfam01882 1435356002199 hypothetical protein; Provisional; Region: PRK13685 1435356002200 Aerotolerance regulator N-terminal; Region: BatA; cl06567 1435356002201 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1435356002202 metal ion-dependent adhesion site (MIDAS); other site 1435356002203 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1435356002204 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1435356002205 NAD(P) binding site [chemical binding]; other site 1435356002206 homotetramer interface [polypeptide binding]; other site 1435356002207 homodimer interface [polypeptide binding]; other site 1435356002208 active site 1435356002209 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 1435356002210 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1435356002211 NAD(P) binding site [chemical binding]; other site 1435356002212 active site 1435356002213 ferrochelatase; Reviewed; Region: hemH; PRK00035 1435356002214 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1435356002215 C-terminal domain interface [polypeptide binding]; other site 1435356002216 active site 1435356002217 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1435356002218 active site 1435356002219 N-terminal domain interface [polypeptide binding]; other site 1435356002220 Predicted transcriptional regulators [Transcription]; Region: COG1733 1435356002221 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1435356002222 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1435356002223 S-adenosylmethionine binding site [chemical binding]; other site 1435356002224 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 1435356002225 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1435356002226 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1435356002227 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1435356002228 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1435356002229 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 1435356002230 Predicted membrane protein [Function unknown]; Region: COG4325 1435356002231 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 1435356002232 MarR family; Region: MarR_2; cl17246 1435356002233 Condensation domain; Region: Condensation; pfam00668 1435356002234 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1435356002235 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1435356002236 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1435356002237 acyl-activating enzyme (AAE) consensus motif; other site 1435356002238 AMP binding site [chemical binding]; other site 1435356002239 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1435356002240 Condensation domain; Region: Condensation; pfam00668 1435356002241 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1435356002242 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1435356002243 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1435356002244 acyl-activating enzyme (AAE) consensus motif; other site 1435356002245 AMP binding site [chemical binding]; other site 1435356002246 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1435356002247 S-adenosylmethionine binding site [chemical binding]; other site 1435356002248 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1435356002249 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1435356002250 Condensation domain; Region: Condensation; pfam00668 1435356002251 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1435356002252 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1435356002253 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1435356002254 acyl-activating enzyme (AAE) consensus motif; other site 1435356002255 AMP binding site [chemical binding]; other site 1435356002256 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1435356002257 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1435356002258 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1435356002259 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 1435356002260 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 1435356002261 heterodimer interface [polypeptide binding]; other site 1435356002262 substrate interaction site [chemical binding]; other site 1435356002263 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1435356002264 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1435356002265 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1435356002266 active site 1435356002267 substrate binding site [chemical binding]; other site 1435356002268 coenzyme B12 binding site [chemical binding]; other site 1435356002269 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1435356002270 B12 binding site [chemical binding]; other site 1435356002271 cobalt ligand [ion binding]; other site 1435356002272 membrane ATPase/protein kinase; Provisional; Region: PRK09435 1435356002273 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 1435356002274 GTP/Mg2+ binding site [chemical binding]; other site 1435356002275 G5 box; other site 1435356002276 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1435356002277 Walker A; other site 1435356002278 G1 box; other site 1435356002279 YhhN-like protein; Region: YhhN; cl01505 1435356002280 Predicted permeases [General function prediction only]; Region: COG0730 1435356002281 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1435356002282 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1435356002283 NAD(P) binding site [chemical binding]; other site 1435356002284 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 1435356002285 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1435356002286 Ligand Binding Site [chemical binding]; other site 1435356002287 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1435356002288 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1435356002289 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1435356002290 active site 1435356002291 hypothetical protein; Provisional; Region: PRK07906 1435356002292 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 1435356002293 putative metal binding site [ion binding]; other site 1435356002294 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1435356002295 substrate binding site [chemical binding]; other site 1435356002296 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1435356002297 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1435356002298 quinone interaction residues [chemical binding]; other site 1435356002299 active site 1435356002300 catalytic residues [active] 1435356002301 FMN binding site [chemical binding]; other site 1435356002302 substrate binding site [chemical binding]; other site 1435356002303 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 1435356002304 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1435356002305 Walker A/P-loop; other site 1435356002306 ATP binding site [chemical binding]; other site 1435356002307 Q-loop/lid; other site 1435356002308 ABC transporter signature motif; other site 1435356002309 Walker B; other site 1435356002310 D-loop; other site 1435356002311 H-loop/switch region; other site 1435356002312 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1435356002313 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1435356002314 ABC-ATPase subunit interface; other site 1435356002315 dimer interface [polypeptide binding]; other site 1435356002316 putative PBP binding regions; other site 1435356002317 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 1435356002318 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1435356002319 intersubunit interface [polypeptide binding]; other site 1435356002320 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 1435356002321 heme binding pocket [chemical binding]; other site 1435356002322 heme ligand [chemical binding]; other site 1435356002323 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1435356002324 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 1435356002325 active site 1435356002326 catalytic tetrad [active] 1435356002327 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 1435356002328 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1435356002329 catalytic core [active] 1435356002330 Protein of unknown function (DUF3090); Region: DUF3090; pfam11290 1435356002331 conserved hypothetical protein; Region: TIGR03843 1435356002332 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1435356002333 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 1435356002334 active site 1435356002335 HIGH motif; other site 1435356002336 nucleotide binding site [chemical binding]; other site 1435356002337 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1435356002338 active site 1435356002339 KMSKS motif; other site 1435356002340 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1435356002341 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1435356002342 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1435356002343 active site 1435356002344 metal binding site [ion binding]; metal-binding site 1435356002345 PhoD-like phosphatase; Region: PhoD; pfam09423 1435356002346 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1435356002347 putative active site [active] 1435356002348 putative metal binding site [ion binding]; other site 1435356002349 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1435356002350 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1435356002351 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1435356002352 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1435356002353 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1435356002354 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1435356002355 hypothetical protein; Validated; Region: PRK00029 1435356002356 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1435356002357 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1435356002358 hypothetical protein; Provisional; Region: PRK06185 1435356002359 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1435356002360 dimer interface [polypeptide binding]; other site 1435356002361 hexamer interface [polypeptide binding]; other site 1435356002362 active site 2 [active] 1435356002363 TIGR02680 family protein; Region: TIGR02680 1435356002364 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1435356002365 Protein of unknown function (DUF2398); Region: DUF2398; cl09875 1435356002366 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 1435356002367 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1435356002368 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1435356002369 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1435356002370 DUF35 OB-fold domain; Region: DUF35; pfam01796 1435356002371 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1435356002372 homotrimer interaction site [polypeptide binding]; other site 1435356002373 putative active site [active] 1435356002374 Predicted transcriptional regulators [Transcription]; Region: COG1733 1435356002375 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1435356002376 Bacterial protein of unknown function (DUF925); Region: DUF925; cl01435 1435356002377 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1435356002378 Cytochrome P450; Region: p450; cl12078 1435356002379 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1435356002380 hydrophobic ligand binding site; other site 1435356002381 hypothetical protein; Provisional; Region: PRK06834 1435356002382 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1435356002383 succinic semialdehyde dehydrogenase; Region: PLN02278 1435356002384 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1435356002385 tetramerization interface [polypeptide binding]; other site 1435356002386 NAD(P) binding site [chemical binding]; other site 1435356002387 catalytic residues [active] 1435356002388 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1435356002389 FAD binding domain; Region: FAD_binding_4; pfam01565 1435356002390 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1435356002391 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 1435356002392 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1435356002393 NAD(P) binding site [chemical binding]; other site 1435356002394 catalytic residues [active] 1435356002395 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1435356002396 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1435356002397 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1435356002398 dimerization interface [polypeptide binding]; other site 1435356002399 malate:quinone oxidoreductase; Validated; Region: PRK05257 1435356002400 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1435356002401 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1435356002402 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1435356002403 FMN binding site [chemical binding]; other site 1435356002404 active site 1435356002405 substrate binding site [chemical binding]; other site 1435356002406 catalytic residue [active] 1435356002407 HTH domain; Region: HTH_11; pfam08279 1435356002408 WYL domain; Region: WYL; pfam13280 1435356002409 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1435356002410 DinB superfamily; Region: DinB_2; pfam12867 1435356002411 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1435356002412 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1435356002413 DNA binding residues [nucleotide binding] 1435356002414 dimerization interface [polypeptide binding]; other site 1435356002415 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1435356002416 nucleotide binding site [chemical binding]; other site 1435356002417 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1435356002418 Cytochrome P450; Region: p450; pfam00067 1435356002419 Cupin domain; Region: Cupin_2; pfam07883 1435356002420 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1435356002421 Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971 1435356002422 Predicted transcriptional regulators [Transcription]; Region: COG1695 1435356002423 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1435356002424 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1435356002425 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1435356002426 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1435356002427 FMN binding site [chemical binding]; other site 1435356002428 substrate binding site [chemical binding]; other site 1435356002429 putative catalytic residue [active] 1435356002430 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1435356002431 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1435356002432 DNA binding residues [nucleotide binding] 1435356002433 dimerization interface [polypeptide binding]; other site 1435356002434 Cupin domain; Region: Cupin_2; cl17218 1435356002435 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1435356002436 Pirin-related protein [General function prediction only]; Region: COG1741 1435356002437 Pirin; Region: Pirin; pfam02678 1435356002438 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1435356002439 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1435356002440 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1435356002441 DNA binding residues [nucleotide binding] 1435356002442 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1435356002443 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1435356002444 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1435356002445 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1435356002446 acyl-activating enzyme (AAE) consensus motif; other site 1435356002447 AMP binding site [chemical binding]; other site 1435356002448 active site 1435356002449 CoA binding site [chemical binding]; other site 1435356002450 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 1435356002451 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1435356002452 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1435356002453 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 1435356002454 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1435356002455 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 1435356002456 phosphate binding site [ion binding]; other site 1435356002457 Methyltransferase domain; Region: Methyltransf_18; pfam12847 1435356002458 S-adenosylmethionine binding site [chemical binding]; other site 1435356002459 GTPase RsgA; Reviewed; Region: PRK01889 1435356002460 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1435356002461 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1435356002462 GTP/Mg2+ binding site [chemical binding]; other site 1435356002463 G4 box; other site 1435356002464 G5 box; other site 1435356002465 G1 box; other site 1435356002466 Switch I region; other site 1435356002467 G2 box; other site 1435356002468 G3 box; other site 1435356002469 Switch II region; other site 1435356002470 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1435356002471 catalytic residue [active] 1435356002472 RibD C-terminal domain; Region: RibD_C; cl17279 1435356002473 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1435356002474 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1435356002475 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1435356002476 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 1435356002477 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 1435356002478 Dynamin family; Region: Dynamin_N; pfam00350 1435356002479 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1435356002480 G2 box; other site 1435356002481 G3 box; other site 1435356002482 Switch II region; other site 1435356002483 G4 box; other site 1435356002484 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1435356002485 Dynamin family; Region: Dynamin_N; pfam00350 1435356002486 G1 box; other site 1435356002487 GTP/Mg2+ binding site [chemical binding]; other site 1435356002488 G2 box; other site 1435356002489 Switch I region; other site 1435356002490 G3 box; other site 1435356002491 Switch II region; other site 1435356002492 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 1435356002493 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1435356002494 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1435356002495 DNA binding residues [nucleotide binding] 1435356002496 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 1435356002497 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1435356002498 nucleotide binding site [chemical binding]; other site 1435356002499 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1435356002500 SBD interface [polypeptide binding]; other site 1435356002501 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 1435356002502 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1435356002503 cobalt transport protein CbiM; Validated; Region: PRK06265 1435356002504 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 1435356002505 UreD urease accessory protein; Region: UreD; cl00530 1435356002506 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1435356002507 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1435356002508 urease subunit alpha; Reviewed; Region: ureC; PRK13206 1435356002509 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1435356002510 subunit interactions [polypeptide binding]; other site 1435356002511 active site 1435356002512 flap region; other site 1435356002513 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1435356002514 alpha-beta subunit interface [polypeptide binding]; other site 1435356002515 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1435356002516 alpha-gamma subunit interface [polypeptide binding]; other site 1435356002517 beta-gamma subunit interface [polypeptide binding]; other site 1435356002518 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1435356002519 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1435356002520 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1435356002521 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1435356002522 active site 1435356002523 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356002524 metabolite-proton symporter; Region: 2A0106; TIGR00883 1435356002525 putative substrate translocation pore; other site 1435356002526 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1435356002527 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1435356002528 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1435356002529 dimerization interface [polypeptide binding]; other site 1435356002530 substrate binding pocket [chemical binding]; other site 1435356002531 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1435356002532 TAP-like protein; Region: Abhydrolase_4; pfam08386 1435356002533 PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668 1435356002534 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1435356002535 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 1435356002536 active site 1435356002537 DNA binding site [nucleotide binding] 1435356002538 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1435356002539 DNA binding site [nucleotide binding] 1435356002540 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1435356002541 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1435356002542 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1435356002543 Sulfatase; Region: Sulfatase; pfam00884 1435356002544 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353 1435356002545 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1435356002546 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1435356002547 active site 1435356002548 catalytic tetrad [active] 1435356002549 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1435356002550 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356002551 putative substrate translocation pore; other site 1435356002552 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1435356002553 MarR family; Region: MarR; pfam01047 1435356002554 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1435356002555 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 1435356002556 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1435356002557 DNA-binding site [nucleotide binding]; DNA binding site 1435356002558 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1435356002559 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1435356002560 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1435356002561 L-lactate permease; Region: Lactate_perm; cl00701 1435356002562 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1435356002563 Cysteine-rich domain; Region: CCG; pfam02754 1435356002564 Cysteine-rich domain; Region: CCG; pfam02754 1435356002565 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 1435356002566 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1435356002567 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1435356002568 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 1435356002569 Transcription factor WhiB; Region: Whib; pfam02467 1435356002570 Predicted transcriptional regulators [Transcription]; Region: COG1695 1435356002571 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356002572 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1435356002573 putative substrate translocation pore; other site 1435356002574 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356002575 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 1435356002576 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1435356002577 CGNR zinc finger; Region: zf-CGNR; pfam11706 1435356002578 HPP family; Region: HPP; pfam04982 1435356002579 amphi-Trp domain; Region: amphi-Trp; TIGR04354 1435356002580 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1435356002581 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 1435356002582 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1435356002583 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1435356002584 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1435356002585 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1435356002586 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1435356002587 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1435356002588 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1435356002589 carboxyltransferase (CT) interaction site; other site 1435356002590 biotinylation site [posttranslational modification]; other site 1435356002591 enoyl-CoA hydratase; Provisional; Region: PRK07827 1435356002592 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1435356002593 substrate binding site [chemical binding]; other site 1435356002594 oxyanion hole (OAH) forming residues; other site 1435356002595 trimer interface [polypeptide binding]; other site 1435356002596 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 1435356002597 carboxylate-amine ligase; Provisional; Region: PRK13517 1435356002598 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1435356002599 Ion channel; Region: Ion_trans_2; pfam07885 1435356002600 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 1435356002601 TrkA-N domain; Region: TrkA_N; pfam02254 1435356002602 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1435356002603 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1435356002604 Cytochrome P450; Region: p450; cl12078 1435356002605 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356002606 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356002607 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1435356002608 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1435356002609 substrate binding pocket [chemical binding]; other site 1435356002610 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1435356002611 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1435356002612 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 1435356002613 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 1435356002614 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1435356002615 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1435356002616 PE-PPE domain; Region: PE-PPE; pfam08237 1435356002617 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1435356002618 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356002619 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356002620 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1435356002621 competence damage-inducible protein A; Provisional; Region: PRK00549 1435356002622 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 1435356002623 MPT binding site; other site 1435356002624 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 1435356002625 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1435356002626 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1435356002627 cyclase homology domain; Region: CHD; cd07302 1435356002628 nucleotidyl binding site; other site 1435356002629 metal binding site [ion binding]; metal-binding site 1435356002630 dimer interface [polypeptide binding]; other site 1435356002631 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1435356002632 Helix-turn-helix domain; Region: HTH_36; pfam13730 1435356002633 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 1435356002634 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1435356002635 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1435356002636 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1435356002637 active site 1435356002638 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1435356002639 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1435356002640 putative acyl-acceptor binding pocket; other site 1435356002641 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1435356002642 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1435356002643 active site 1435356002644 motif I; other site 1435356002645 motif II; other site 1435356002646 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1435356002647 active site 1435356002648 motif I; other site 1435356002649 motif II; other site 1435356002650 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1435356002651 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356002652 D-galactonate transporter; Region: 2A0114; TIGR00893 1435356002653 putative substrate translocation pore; other site 1435356002654 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1435356002655 Amidase; Region: Amidase; cl11426 1435356002656 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1435356002657 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1435356002658 active site 1435356002659 phosphorylation site [posttranslational modification] 1435356002660 intermolecular recognition site; other site 1435356002661 dimerization interface [polypeptide binding]; other site 1435356002662 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1435356002663 DNA binding residues [nucleotide binding] 1435356002664 dimerization interface [polypeptide binding]; other site 1435356002665 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1435356002666 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1435356002667 FMN-binding pocket [chemical binding]; other site 1435356002668 flavin binding motif; other site 1435356002669 phosphate binding motif [ion binding]; other site 1435356002670 beta-alpha-beta structure motif; other site 1435356002671 NAD binding pocket [chemical binding]; other site 1435356002672 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1435356002673 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1435356002674 catalytic loop [active] 1435356002675 iron binding site [ion binding]; other site 1435356002676 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1435356002677 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1435356002678 NAD(P) binding site [chemical binding]; other site 1435356002679 active site 1435356002680 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1435356002681 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1435356002682 [2Fe-2S] cluster binding site [ion binding]; other site 1435356002683 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 1435356002684 putative alpha subunit interface [polypeptide binding]; other site 1435356002685 putative active site [active] 1435356002686 putative substrate binding site [chemical binding]; other site 1435356002687 Fe binding site [ion binding]; other site 1435356002688 SnoaL-like domain; Region: SnoaL_4; pfam13577 1435356002689 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1435356002690 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1435356002691 active site 1435356002692 PAS domain; Region: PAS_8; pfam13188 1435356002693 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1435356002694 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1435356002695 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1435356002696 putative active site [active] 1435356002697 heme pocket [chemical binding]; other site 1435356002698 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1435356002699 dimer interface [polypeptide binding]; other site 1435356002700 phosphorylation site [posttranslational modification] 1435356002701 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1435356002702 ATP binding site [chemical binding]; other site 1435356002703 Mg2+ binding site [ion binding]; other site 1435356002704 G-X-G motif; other site 1435356002705 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 1435356002706 ethanolamine permease; Region: 2A0305; TIGR00908 1435356002707 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1435356002708 Cupin superfamily protein; Region: Cupin_4; pfam08007 1435356002709 Cupin-like domain; Region: Cupin_8; pfam13621 1435356002710 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1435356002711 Putative cyclase; Region: Cyclase; pfam04199 1435356002712 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 1435356002713 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1435356002714 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1435356002715 acyl-activating enzyme (AAE) consensus motif; other site 1435356002716 putative AMP binding site [chemical binding]; other site 1435356002717 putative active site [active] 1435356002718 putative CoA binding site [chemical binding]; other site 1435356002719 Putative cyclase; Region: Cyclase; pfam04199 1435356002720 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1435356002721 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1435356002722 non-specific DNA binding site [nucleotide binding]; other site 1435356002723 salt bridge; other site 1435356002724 sequence-specific DNA binding site [nucleotide binding]; other site 1435356002725 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356002726 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356002727 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1435356002728 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1435356002729 active site 1435356002730 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 1435356002731 putative dimer interface [polypeptide binding]; other site 1435356002732 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1435356002733 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1435356002734 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1435356002735 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1435356002736 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1435356002737 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1435356002738 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1435356002739 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1435356002740 Predicted transcriptional regulators [Transcription]; Region: COG1733 1435356002741 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1435356002742 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1435356002743 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1435356002744 NAD(P) binding site [chemical binding]; other site 1435356002745 active site 1435356002746 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1435356002747 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1435356002748 Zn binding site [ion binding]; other site 1435356002749 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1435356002750 active site 1435356002751 DNA binding site [nucleotide binding] 1435356002752 Int/Topo IB signature motif; other site 1435356002753 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 1435356002754 A new structural DNA glycosylase; Region: AlkD_like; cd06561 1435356002755 active site 1435356002756 putative phosphoketolase; Provisional; Region: PRK05261 1435356002757 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 1435356002758 TPP-binding site; other site 1435356002759 XFP C-terminal domain; Region: XFP_C; pfam09363 1435356002760 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1435356002761 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1435356002762 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1435356002763 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1435356002764 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1435356002765 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1435356002766 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1435356002767 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1435356002768 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-II; Region: Lumazine_synthase-II; cd09208 1435356002769 active site 1435356002770 homopentamer interface [polypeptide binding]; other site 1435356002771 dimer interface [polypeptide binding]; other site 1435356002772 classical (c) SDRs; Region: SDR_c; cd05233 1435356002773 active site 1435356002774 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1435356002775 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1435356002776 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356002777 putative substrate translocation pore; other site 1435356002778 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1435356002779 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1435356002780 PAC2 family; Region: PAC2; pfam09754 1435356002781 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1435356002782 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 1435356002783 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1435356002784 substrate binding pocket [chemical binding]; other site 1435356002785 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1435356002786 B12 binding site [chemical binding]; other site 1435356002787 cobalt ligand [ion binding]; other site 1435356002788 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1435356002789 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1435356002790 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1435356002791 motif II; other site 1435356002792 rhodanese superfamily protein; Provisional; Region: PRK05320 1435356002793 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1435356002794 active site residue [active] 1435356002795 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1435356002796 active site 1435356002797 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 1435356002798 homodimer interface [polypeptide binding]; other site 1435356002799 putative metal binding site [ion binding]; other site 1435356002800 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1435356002801 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1435356002802 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1435356002803 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1435356002804 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1435356002805 active site 2 [active] 1435356002806 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1435356002807 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1435356002808 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1435356002809 S-adenosylmethionine binding site [chemical binding]; other site 1435356002810 proteasome ATPase; Region: pup_AAA; TIGR03689 1435356002811 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1435356002812 Walker A motif; other site 1435356002813 ATP binding site [chemical binding]; other site 1435356002814 Walker B motif; other site 1435356002815 arginine finger; other site 1435356002816 Domain of unknown function (DUF385); Region: DUF385; cl04387 1435356002817 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 1435356002818 Pup-like protein; Region: Pup; cl05289 1435356002819 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 1435356002820 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1435356002821 active site 1435356002822 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 1435356002823 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1435356002824 active site 1435356002825 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1435356002826 putative lipid kinase; Reviewed; Region: PRK13057 1435356002827 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 1435356002828 Predicted transcriptional regulator [Transcription]; Region: COG2378 1435356002829 WYL domain; Region: WYL; pfam13280 1435356002830 Predicted transcriptional regulator [Transcription]; Region: COG2378 1435356002831 WYL domain; Region: WYL; pfam13280 1435356002832 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 1435356002833 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 1435356002834 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1435356002835 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 1435356002836 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1435356002837 ATP binding site [chemical binding]; other site 1435356002838 putative Mg++ binding site [ion binding]; other site 1435356002839 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1435356002840 nucleotide binding region [chemical binding]; other site 1435356002841 ATP-binding site [chemical binding]; other site 1435356002842 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1435356002843 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1435356002844 5'-3' exonuclease; Region: 53EXOc; smart00475 1435356002845 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1435356002846 active site 1435356002847 metal binding site 1 [ion binding]; metal-binding site 1435356002848 putative 5' ssDNA interaction site; other site 1435356002849 metal binding site 3; metal-binding site 1435356002850 metal binding site 2 [ion binding]; metal-binding site 1435356002851 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1435356002852 putative DNA binding site [nucleotide binding]; other site 1435356002853 putative metal binding site [ion binding]; other site 1435356002854 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1435356002855 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1435356002856 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 1435356002857 active site 1435356002858 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1435356002859 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1435356002860 NAD(P) binding site [chemical binding]; other site 1435356002861 active site 1435356002862 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1435356002863 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1435356002864 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1435356002865 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1435356002866 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 1435356002867 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1435356002868 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1435356002869 trimer interface [polypeptide binding]; other site 1435356002870 active site 1435356002871 substrate binding site [chemical binding]; other site 1435356002872 CoA binding site [chemical binding]; other site 1435356002873 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1435356002874 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1435356002875 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1435356002876 hypothetical protein; Provisional; Region: PRK10621 1435356002877 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1435356002878 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 1435356002879 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1435356002880 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1435356002881 active site 1435356002882 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1435356002883 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1435356002884 putative active site [active] 1435356002885 catalytic triad [active] 1435356002886 putative dimer interface [polypeptide binding]; other site 1435356002887 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1435356002888 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1435356002889 Ligand binding site; other site 1435356002890 Putative Catalytic site; other site 1435356002891 DXD motif; other site 1435356002892 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1435356002893 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 1435356002894 arogenate dehydrogenase; Region: PLN02256 1435356002895 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1435356002896 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1435356002897 glutamine binding [chemical binding]; other site 1435356002898 catalytic triad [active] 1435356002899 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1435356002900 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1435356002901 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1435356002902 Chorismate mutase type II; Region: CM_2; smart00830 1435356002903 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1435356002904 Condensation domain; Region: Condensation; pfam00668 1435356002905 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1435356002906 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1435356002907 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1435356002908 acyl-activating enzyme (AAE) consensus motif; other site 1435356002909 AMP binding site [chemical binding]; other site 1435356002910 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1435356002911 Condensation domain; Region: Condensation; pfam00668 1435356002912 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1435356002913 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1435356002914 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1435356002915 acyl-activating enzyme (AAE) consensus motif; other site 1435356002916 AMP binding site [chemical binding]; other site 1435356002917 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1435356002918 peptide synthase; Provisional; Region: PRK12467 1435356002919 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1435356002920 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1435356002921 acyl-activating enzyme (AAE) consensus motif; other site 1435356002922 AMP binding site [chemical binding]; other site 1435356002923 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1435356002924 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1435356002925 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1435356002926 acyl-activating enzyme (AAE) consensus motif; other site 1435356002927 AMP binding site [chemical binding]; other site 1435356002928 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1435356002929 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1435356002930 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1435356002931 acyl-activating enzyme (AAE) consensus motif; other site 1435356002932 AMP binding site [chemical binding]; other site 1435356002933 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1435356002934 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1435356002935 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1435356002936 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1435356002937 acyl-activating enzyme (AAE) consensus motif; other site 1435356002938 AMP binding site [chemical binding]; other site 1435356002939 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1435356002940 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 1435356002941 Zeta toxin; Region: Zeta_toxin; pfam06414 1435356002942 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 1435356002943 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1435356002944 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1435356002945 S-adenosylmethionine binding site [chemical binding]; other site 1435356002946 HNH endonuclease; Region: HNH; pfam01844 1435356002947 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1435356002948 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1435356002949 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1435356002950 dimer interface [polypeptide binding]; other site 1435356002951 phosphorylation site [posttranslational modification] 1435356002952 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1435356002953 ATP binding site [chemical binding]; other site 1435356002954 Mg2+ binding site [ion binding]; other site 1435356002955 G-X-G motif; other site 1435356002956 proteobacterial dedicated sortase system response regulator; Region: marine_sort_RR; TIGR03787 1435356002957 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1435356002958 active site 1435356002959 phosphorylation site [posttranslational modification] 1435356002960 intermolecular recognition site; other site 1435356002961 dimerization interface [polypeptide binding]; other site 1435356002962 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1435356002963 DNA binding site [nucleotide binding] 1435356002964 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1435356002965 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356002966 putative substrate translocation pore; other site 1435356002967 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 1435356002968 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 1435356002969 DNA binding residues [nucleotide binding] 1435356002970 dimer interface [polypeptide binding]; other site 1435356002971 [2Fe-2S] cluster binding site [ion binding]; other site 1435356002972 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1435356002973 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1435356002974 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1435356002975 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1435356002976 NAD(P) binding site [chemical binding]; other site 1435356002977 active site 1435356002978 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1435356002979 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1435356002980 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1435356002981 dimerization interface [polypeptide binding]; other site 1435356002982 putative Zn2+ binding site [ion binding]; other site 1435356002983 putative DNA binding site [nucleotide binding]; other site 1435356002984 short chain dehydrogenase; Provisional; Region: PRK07109 1435356002985 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 1435356002986 putative NAD(P) binding site [chemical binding]; other site 1435356002987 active site 1435356002988 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1435356002989 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1435356002990 thiamine pyrophosphate protein; Provisional; Region: PRK08273 1435356002991 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1435356002992 PYR/PP interface [polypeptide binding]; other site 1435356002993 dimer interface [polypeptide binding]; other site 1435356002994 tetramer interface [polypeptide binding]; other site 1435356002995 TPP binding site [chemical binding]; other site 1435356002996 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1435356002997 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1435356002998 TPP-binding site [chemical binding]; other site 1435356002999 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1435356003000 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1435356003001 metal binding site [ion binding]; metal-binding site 1435356003002 substrate binding pocket [chemical binding]; other site 1435356003003 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1435356003004 FAD binding domain; Region: FAD_binding_4; pfam01565 1435356003005 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1435356003006 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1435356003007 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1435356003008 D-pathway; other site 1435356003009 Putative ubiquinol binding site [chemical binding]; other site 1435356003010 Low-spin heme (heme b) binding site [chemical binding]; other site 1435356003011 Putative water exit pathway; other site 1435356003012 Binuclear center (heme o3/CuB) [ion binding]; other site 1435356003013 K-pathway; other site 1435356003014 Putative proton exit pathway; other site 1435356003015 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1435356003016 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1435356003017 Fic family protein [Function unknown]; Region: COG3177 1435356003018 Fic/DOC family; Region: Fic; pfam02661 1435356003019 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 1435356003020 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1435356003021 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1435356003022 active site 1435356003023 DNA binding site [nucleotide binding] 1435356003024 Int/Topo IB signature motif; other site 1435356003025 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1435356003026 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1435356003027 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1435356003028 CoenzymeA binding site [chemical binding]; other site 1435356003029 subunit interaction site [polypeptide binding]; other site 1435356003030 PHB binding site; other site 1435356003031 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1435356003032 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1435356003033 ABC-ATPase subunit interface; other site 1435356003034 dimer interface [polypeptide binding]; other site 1435356003035 putative PBP binding regions; other site 1435356003036 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1435356003037 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1435356003038 dimer interface [polypeptide binding]; other site 1435356003039 putative PBP binding regions; other site 1435356003040 ABC-ATPase subunit interface; other site 1435356003041 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1435356003042 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1435356003043 Walker A/P-loop; other site 1435356003044 ATP binding site [chemical binding]; other site 1435356003045 Q-loop/lid; other site 1435356003046 ABC transporter signature motif; other site 1435356003047 Walker B; other site 1435356003048 D-loop; other site 1435356003049 H-loop/switch region; other site 1435356003050 Predicted transcriptional regulator [Transcription]; Region: COG3682 1435356003051 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1435356003052 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1435356003053 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1435356003054 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1435356003055 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1435356003056 S-adenosylmethionine binding site [chemical binding]; other site 1435356003057 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1435356003058 Domain of unknown function DUF21; Region: DUF21; pfam01595 1435356003059 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1435356003060 Transporter associated domain; Region: CorC_HlyC; smart01091 1435356003061 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1435356003062 Domain of unknown function DUF21; Region: DUF21; pfam01595 1435356003063 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1435356003064 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 1435356003065 active site 1435356003066 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1435356003067 metal ion-dependent adhesion site (MIDAS); other site 1435356003068 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1435356003069 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1435356003070 putative active site [active] 1435356003071 putative metal binding site [ion binding]; other site 1435356003072 glycine dehydrogenase; Provisional; Region: PRK05367 1435356003073 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1435356003074 tetramer interface [polypeptide binding]; other site 1435356003075 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1435356003076 catalytic residue [active] 1435356003077 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1435356003078 tetramer interface [polypeptide binding]; other site 1435356003079 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1435356003080 catalytic residue [active] 1435356003081 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1435356003082 DNA binding residues [nucleotide binding] 1435356003083 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1435356003084 putative dimer interface [polypeptide binding]; other site 1435356003085 Bifunctional nuclease; Region: DNase-RNase; pfam02577 1435356003086 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1435356003087 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1435356003088 DNA binding residues [nucleotide binding] 1435356003089 dimer interface [polypeptide binding]; other site 1435356003090 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 1435356003091 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1435356003092 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1435356003093 phosphopeptide binding site; other site 1435356003094 glycine cleavage system protein H; Provisional; Region: PRK13380 1435356003095 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1435356003096 lipoyl attachment site [posttranslational modification]; other site 1435356003097 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1435356003098 Protein of unknown function (DUF1290); Region: DUF1290; cl01587 1435356003099 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1435356003100 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1435356003101 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1435356003102 putative active site [active] 1435356003103 putative CoA binding site [chemical binding]; other site 1435356003104 nudix motif; other site 1435356003105 metal binding site [ion binding]; metal-binding site 1435356003106 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1435356003107 putative active site [active] 1435356003108 putative substrate binding site [chemical binding]; other site 1435356003109 ATP binding site [chemical binding]; other site 1435356003110 Protein of unknown function (DUF419); Region: DUF419; pfam04237 1435356003111 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1435356003112 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1435356003113 dimer interface [polypeptide binding]; other site 1435356003114 HTH domain; Region: HTH_11; pfam08279 1435356003115 WYL domain; Region: WYL; pfam13280 1435356003116 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1435356003117 homotrimer interaction site [polypeptide binding]; other site 1435356003118 putative active site [active] 1435356003119 GTP-binding protein Der; Reviewed; Region: PRK03003 1435356003120 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1435356003121 G1 box; other site 1435356003122 GTP/Mg2+ binding site [chemical binding]; other site 1435356003123 Switch I region; other site 1435356003124 G2 box; other site 1435356003125 Switch II region; other site 1435356003126 G3 box; other site 1435356003127 G4 box; other site 1435356003128 G5 box; other site 1435356003129 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1435356003130 G1 box; other site 1435356003131 GTP/Mg2+ binding site [chemical binding]; other site 1435356003132 Switch I region; other site 1435356003133 G2 box; other site 1435356003134 G3 box; other site 1435356003135 Switch II region; other site 1435356003136 G4 box; other site 1435356003137 G5 box; other site 1435356003138 cytidylate kinase; Provisional; Region: cmk; PRK00023 1435356003139 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1435356003140 CMP-binding site; other site 1435356003141 The sites determining sugar specificity; other site 1435356003142 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1435356003143 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1435356003144 RNA binding surface [nucleotide binding]; other site 1435356003145 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1435356003146 active site 1435356003147 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1435356003148 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1435356003149 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1435356003150 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1435356003151 P-loop; other site 1435356003152 Magnesium ion binding site [ion binding]; other site 1435356003153 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1435356003154 Magnesium ion binding site [ion binding]; other site 1435356003155 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1435356003156 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1435356003157 active site 1435356003158 Int/Topo IB signature motif; other site 1435356003159 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1435356003160 dimer interface [polypeptide binding]; other site 1435356003161 active site 1435356003162 ADP-ribose binding site [chemical binding]; other site 1435356003163 nudix motif; other site 1435356003164 metal binding site [ion binding]; metal-binding site 1435356003165 CTP synthetase; Validated; Region: pyrG; PRK05380 1435356003166 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1435356003167 Catalytic site [active] 1435356003168 active site 1435356003169 UTP binding site [chemical binding]; other site 1435356003170 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1435356003171 active site 1435356003172 putative oxyanion hole; other site 1435356003173 catalytic triad [active] 1435356003174 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 1435356003175 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 1435356003176 Thiamine pyrophosphokinase; Region: TPK; cl08415 1435356003177 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1435356003178 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1435356003179 Walker A/P-loop; other site 1435356003180 ATP binding site [chemical binding]; other site 1435356003181 Q-loop/lid; other site 1435356003182 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1435356003183 ABC transporter signature motif; other site 1435356003184 Walker B; other site 1435356003185 D-loop; other site 1435356003186 H-loop/switch region; other site 1435356003187 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 1435356003188 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1435356003189 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1435356003190 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1435356003191 RNA binding surface [nucleotide binding]; other site 1435356003192 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1435356003193 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1435356003194 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1435356003195 active site 1435356003196 motif I; other site 1435356003197 motif II; other site 1435356003198 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1435356003199 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1435356003200 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1435356003201 active site 1435356003202 HIGH motif; other site 1435356003203 dimer interface [polypeptide binding]; other site 1435356003204 KMSKS motif; other site 1435356003205 S4 RNA-binding domain; Region: S4; smart00363 1435356003206 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1435356003207 active site 1435356003208 DNA binding site [nucleotide binding] 1435356003209 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1435356003210 acyl-CoA synthetase; Validated; Region: PRK07868 1435356003211 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1435356003212 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1435356003213 acyl-activating enzyme (AAE) consensus motif; other site 1435356003214 AMP binding site [chemical binding]; other site 1435356003215 active site 1435356003216 CoA binding site [chemical binding]; other site 1435356003217 argininosuccinate lyase; Provisional; Region: PRK00855 1435356003218 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1435356003219 active sites [active] 1435356003220 tetramer interface [polypeptide binding]; other site 1435356003221 argininosuccinate synthase; Provisional; Region: PRK13820 1435356003222 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1435356003223 ANP binding site [chemical binding]; other site 1435356003224 Substrate Binding Site II [chemical binding]; other site 1435356003225 Substrate Binding Site I [chemical binding]; other site 1435356003226 Arginine repressor [Transcription]; Region: ArgR; COG1438 1435356003227 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1435356003228 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1435356003229 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1435356003230 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1435356003231 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1435356003232 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 1435356003233 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1435356003234 inhibitor-cofactor binding pocket; inhibition site 1435356003235 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1435356003236 catalytic residue [active] 1435356003237 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1435356003238 feedback inhibition sensing region; other site 1435356003239 homohexameric interface [polypeptide binding]; other site 1435356003240 nucleotide binding site [chemical binding]; other site 1435356003241 N-acetyl-L-glutamate binding site [chemical binding]; other site 1435356003242 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1435356003243 heterotetramer interface [polypeptide binding]; other site 1435356003244 active site pocket [active] 1435356003245 cleavage site 1435356003246 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1435356003247 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1435356003248 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1435356003249 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1435356003250 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1435356003251 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1435356003252 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1435356003253 putative tRNA-binding site [nucleotide binding]; other site 1435356003254 B3/4 domain; Region: B3_4; pfam03483 1435356003255 tRNA synthetase B5 domain; Region: B5; smart00874 1435356003256 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1435356003257 dimer interface [polypeptide binding]; other site 1435356003258 motif 1; other site 1435356003259 motif 3; other site 1435356003260 motif 2; other site 1435356003261 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1435356003262 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1435356003263 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1435356003264 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1435356003265 dimer interface [polypeptide binding]; other site 1435356003266 motif 1; other site 1435356003267 active site 1435356003268 motif 2; other site 1435356003269 motif 3; other site 1435356003270 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1435356003271 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1435356003272 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1435356003273 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1435356003274 23S rRNA binding site [nucleotide binding]; other site 1435356003275 L21 binding site [polypeptide binding]; other site 1435356003276 L13 binding site [polypeptide binding]; other site 1435356003277 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1435356003278 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1435356003279 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1435356003280 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1435356003281 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1435356003282 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1435356003283 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1435356003284 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1435356003285 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1435356003286 Transposase; Region: HTH_Tnp_1; cl17663 1435356003287 Integrase core domain; Region: rve; pfam00665 1435356003288 Integrase core domain; Region: rve_2; pfam13333 1435356003289 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1435356003290 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1435356003291 catalytic residues [active] 1435356003292 catalytic nucleophile [active] 1435356003293 Presynaptic Site I dimer interface [polypeptide binding]; other site 1435356003294 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1435356003295 Synaptic Flat tetramer interface [polypeptide binding]; other site 1435356003296 Synaptic Site I dimer interface [polypeptide binding]; other site 1435356003297 DNA binding site [nucleotide binding] 1435356003298 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1435356003299 DNA-binding interface [nucleotide binding]; DNA binding site 1435356003300 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1435356003301 Helix-turn-helix domain; Region: HTH_38; pfam13936 1435356003302 Integrase core domain; Region: rve; pfam00665 1435356003303 transposase/IS protein; Provisional; Region: PRK09183 1435356003304 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1435356003305 Walker A motif; other site 1435356003306 ATP binding site [chemical binding]; other site 1435356003307 Walker B motif; other site 1435356003308 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1435356003309 Transposase; Region: HTH_Tnp_1; cl17663 1435356003310 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1435356003311 HTH-like domain; Region: HTH_21; pfam13276 1435356003312 Integrase core domain; Region: rve; pfam00665 1435356003313 Integrase core domain; Region: rve_3; pfam13683 1435356003314 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1435356003315 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1435356003316 catalytic residues [active] 1435356003317 catalytic nucleophile [active] 1435356003318 Recombinase; Region: Recombinase; pfam07508 1435356003319 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1435356003320 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1435356003321 putative active site [active] 1435356003322 putative metal binding site [ion binding]; other site 1435356003323 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1435356003324 Predicted membrane protein [Function unknown]; Region: COG2259 1435356003325 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1435356003326 Part of AAA domain; Region: AAA_19; pfam13245 1435356003327 Family description; Region: UvrD_C_2; pfam13538 1435356003328 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1435356003329 Ligand Binding Site [chemical binding]; other site 1435356003330 excinuclease ABC subunit B; Provisional; Region: PRK05298 1435356003331 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1435356003332 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1435356003333 nucleotide binding region [chemical binding]; other site 1435356003334 ATP-binding site [chemical binding]; other site 1435356003335 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1435356003336 UvrB/uvrC motif; Region: UVR; pfam02151 1435356003337 Protein of unknown function (DUF402); Region: DUF402; cl00979 1435356003338 Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Region: SLC5sbd_DUR3; cd11476 1435356003339 Na binding site [ion binding]; other site 1435356003340 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1435356003341 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1435356003342 dimerization interface [polypeptide binding]; other site 1435356003343 DNA binding residues [nucleotide binding] 1435356003344 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1435356003345 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 1435356003346 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1435356003347 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1435356003348 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1435356003349 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 1435356003350 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1435356003351 CoA-binding site [chemical binding]; other site 1435356003352 ATP-binding [chemical binding]; other site 1435356003353 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1435356003354 Hypothetical protein TTHB210, a sigma(E)-regulated gene product found in Thermus thermophilus, and similar proteins; Region: TTHB210-like; cd11669 1435356003355 oligomer interface [polypeptide binding]; other site 1435356003356 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1435356003357 FAD binding domain; Region: FAD_binding_4; pfam01565 1435356003358 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1435356003359 DNA binding site [nucleotide binding] 1435356003360 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1435356003361 AAA ATPase domain; Region: AAA_16; pfam13191 1435356003362 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356003363 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1435356003364 putative substrate translocation pore; other site 1435356003365 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356003366 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 1435356003367 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1435356003368 RNA binding site [nucleotide binding]; other site 1435356003369 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1435356003370 RNA binding site [nucleotide binding]; other site 1435356003371 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1435356003372 RNA binding site [nucleotide binding]; other site 1435356003373 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1435356003374 RNA binding site [nucleotide binding]; other site 1435356003375 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1435356003376 S-adenosylmethionine binding site [chemical binding]; other site 1435356003377 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1435356003378 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1435356003379 Walker A/P-loop; other site 1435356003380 ATP binding site [chemical binding]; other site 1435356003381 Q-loop/lid; other site 1435356003382 ABC transporter signature motif; other site 1435356003383 Walker B; other site 1435356003384 D-loop; other site 1435356003385 H-loop/switch region; other site 1435356003386 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1435356003387 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1435356003388 dimer interface [polypeptide binding]; other site 1435356003389 conserved gate region; other site 1435356003390 putative PBP binding loops; other site 1435356003391 ABC-ATPase subunit interface; other site 1435356003392 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1435356003393 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1435356003394 substrate binding pocket [chemical binding]; other site 1435356003395 membrane-bound complex binding site; other site 1435356003396 hinge residues; other site 1435356003397 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1435356003398 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1435356003399 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1435356003400 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1435356003401 conserved cys residue [active] 1435356003402 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1435356003403 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1435356003404 catalytic residues [active] 1435356003405 DNA polymerase I; Provisional; Region: PRK05755 1435356003406 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1435356003407 active site 1435356003408 metal binding site 1 [ion binding]; metal-binding site 1435356003409 putative 5' ssDNA interaction site; other site 1435356003410 metal binding site 3; metal-binding site 1435356003411 metal binding site 2 [ion binding]; metal-binding site 1435356003412 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1435356003413 putative DNA binding site [nucleotide binding]; other site 1435356003414 putative metal binding site [ion binding]; other site 1435356003415 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1435356003416 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1435356003417 active site 1435356003418 DNA binding site [nucleotide binding] 1435356003419 catalytic site [active] 1435356003420 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1435356003421 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1435356003422 TM-ABC transporter signature motif; other site 1435356003423 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1435356003424 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1435356003425 TM-ABC transporter signature motif; other site 1435356003426 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1435356003427 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1435356003428 Walker A/P-loop; other site 1435356003429 ATP binding site [chemical binding]; other site 1435356003430 Q-loop/lid; other site 1435356003431 ABC transporter signature motif; other site 1435356003432 Walker B; other site 1435356003433 D-loop; other site 1435356003434 H-loop/switch region; other site 1435356003435 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1435356003436 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1435356003437 Walker A/P-loop; other site 1435356003438 ATP binding site [chemical binding]; other site 1435356003439 Q-loop/lid; other site 1435356003440 ABC transporter signature motif; other site 1435356003441 Walker B; other site 1435356003442 D-loop; other site 1435356003443 H-loop/switch region; other site 1435356003444 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1435356003445 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1435356003446 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1435356003447 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1435356003448 active site 1435356003449 phosphorylation site [posttranslational modification] 1435356003450 intermolecular recognition site; other site 1435356003451 dimerization interface [polypeptide binding]; other site 1435356003452 ANTAR domain; Region: ANTAR; pfam03861 1435356003453 LexA repressor; Validated; Region: PRK00215 1435356003454 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1435356003455 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1435356003456 Catalytic site [active] 1435356003457 Domain of unknown function (DUF4389); Region: DUF4389; pfam14333 1435356003458 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 1435356003459 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1435356003460 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1435356003461 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 1435356003462 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1435356003463 Ion channel; Region: Ion_trans_2; pfam07885 1435356003464 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1435356003465 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1435356003466 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1435356003467 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1435356003468 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1435356003469 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1435356003470 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1435356003471 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1435356003472 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1435356003473 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1435356003474 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1435356003475 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1435356003476 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 1435356003477 4Fe-4S binding domain; Region: Fer4; pfam00037 1435356003478 4Fe-4S binding domain; Region: Fer4; pfam00037 1435356003479 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1435356003480 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1435356003481 NADH dehydrogenase subunit G; Validated; Region: PRK07860 1435356003482 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1435356003483 catalytic loop [active] 1435356003484 iron binding site [ion binding]; other site 1435356003485 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1435356003486 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1435356003487 molybdopterin cofactor binding site; other site 1435356003488 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1435356003489 molybdopterin cofactor binding site; other site 1435356003490 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 1435356003491 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1435356003492 putative dimer interface [polypeptide binding]; other site 1435356003493 [2Fe-2S] cluster binding site [ion binding]; other site 1435356003494 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 1435356003495 SLBB domain; Region: SLBB; pfam10531 1435356003496 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1435356003497 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 1435356003498 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1435356003499 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 1435356003500 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1435356003501 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1435356003502 NADH dehydrogenase subunit A; Validated; Region: PRK07928 1435356003503 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1435356003504 active site 1435356003505 phosphorylation site [posttranslational modification] 1435356003506 intermolecular recognition site; other site 1435356003507 dimerization interface [polypeptide binding]; other site 1435356003508 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1435356003509 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1435356003510 siderophore binding site; other site 1435356003511 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1435356003512 dimer interface [polypeptide binding]; other site 1435356003513 conserved gate region; other site 1435356003514 ABC-ATPase subunit interface; other site 1435356003515 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1435356003516 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1435356003517 Walker A/P-loop; other site 1435356003518 ATP binding site [chemical binding]; other site 1435356003519 Q-loop/lid; other site 1435356003520 ABC transporter signature motif; other site 1435356003521 Walker B; other site 1435356003522 D-loop; other site 1435356003523 H-loop/switch region; other site 1435356003524 NIL domain; Region: NIL; cl09633 1435356003525 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1435356003526 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1435356003527 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 1435356003528 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1435356003529 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1435356003530 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1435356003531 conserved cys residue [active] 1435356003532 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1435356003533 MarR family; Region: MarR_2; pfam12802 1435356003534 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1435356003535 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1435356003536 active site 1435356003537 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1435356003538 catalytic triad [active] 1435356003539 dimer interface [polypeptide binding]; other site 1435356003540 pyruvate kinase; Provisional; Region: PRK06247 1435356003541 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1435356003542 domain interfaces; other site 1435356003543 active site 1435356003544 TM2 domain; Region: TM2; pfam05154 1435356003545 Prolipoprotein diacylglyceryltransferase [Cell envelope biogenesis, outer membrane]; Region: Lgt; COG0682 1435356003546 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1435356003547 substrate binding site [chemical binding]; other site 1435356003548 active site 1435356003549 catalytic residues [active] 1435356003550 heterodimer interface [polypeptide binding]; other site 1435356003551 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1435356003552 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1435356003553 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1435356003554 catalytic residue [active] 1435356003555 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1435356003556 active site 1435356003557 ribulose/triose binding site [chemical binding]; other site 1435356003558 phosphate binding site [ion binding]; other site 1435356003559 substrate (anthranilate) binding pocket [chemical binding]; other site 1435356003560 product (indole) binding pocket [chemical binding]; other site 1435356003561 anthranilate synthase component I; Provisional; Region: PRK13571 1435356003562 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1435356003563 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1435356003564 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1435356003565 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1435356003566 putative active site [active] 1435356003567 metal binding site [ion binding]; metal-binding site 1435356003568 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1435356003569 Tautomerase enzyme; Region: Tautomerase; pfam01361 1435356003570 active site 1 [active] 1435356003571 dimer interface [polypeptide binding]; other site 1435356003572 hexamer interface [polypeptide binding]; other site 1435356003573 active site 2 [active] 1435356003574 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1435356003575 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1435356003576 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1435356003577 substrate binding site [chemical binding]; other site 1435356003578 glutamase interaction surface [polypeptide binding]; other site 1435356003579 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1435356003580 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1435356003581 active site 1435356003582 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1435356003583 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1435356003584 catalytic residues [active] 1435356003585 Predicted transcriptional regulator [Transcription]; Region: COG2378 1435356003586 WYL domain; Region: WYL; pfam13280 1435356003587 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1435356003588 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1435356003589 putative active site [active] 1435356003590 oxyanion strand; other site 1435356003591 catalytic triad [active] 1435356003592 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356003593 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1435356003594 putative substrate translocation pore; other site 1435356003595 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1435356003596 putative active site pocket [active] 1435356003597 4-fold oligomerization interface [polypeptide binding]; other site 1435356003598 metal binding residues [ion binding]; metal-binding site 1435356003599 3-fold/trimer interface [polypeptide binding]; other site 1435356003600 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 1435356003601 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1435356003602 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1435356003603 homodimer interface [polypeptide binding]; other site 1435356003604 catalytic residue [active] 1435356003605 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 1435356003606 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1435356003607 NAD binding site [chemical binding]; other site 1435356003608 dimerization interface [polypeptide binding]; other site 1435356003609 product binding site; other site 1435356003610 substrate binding site [chemical binding]; other site 1435356003611 zinc binding site [ion binding]; other site 1435356003612 catalytic residues [active] 1435356003613 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1435356003614 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1435356003615 non-specific DNA binding site [nucleotide binding]; other site 1435356003616 salt bridge; other site 1435356003617 sequence-specific DNA binding site [nucleotide binding]; other site 1435356003618 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 1435356003619 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 1435356003620 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1435356003621 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 1435356003622 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1435356003623 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1435356003624 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 1435356003625 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 1435356003626 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1435356003627 dimerization interface [polypeptide binding]; other site 1435356003628 active site 1435356003629 L-aspartate oxidase; Provisional; Region: PRK07804 1435356003630 L-aspartate oxidase; Provisional; Region: PRK06175 1435356003631 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1435356003632 quinolinate synthetase; Provisional; Region: PRK09375 1435356003633 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1435356003634 nudix motif; other site 1435356003635 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356003636 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356003637 short chain dehydrogenase; Provisional; Region: PRK08263 1435356003638 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1435356003639 NADP binding site [chemical binding]; other site 1435356003640 active site 1435356003641 steroid binding site; other site 1435356003642 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1435356003643 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1435356003644 Protein of unknown function, DUF488; Region: DUF488; pfam04343 1435356003645 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1435356003646 biotin synthase; Validated; Region: PRK06256 1435356003647 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1435356003648 FeS/SAM binding site; other site 1435356003649 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1435356003650 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1435356003651 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356003652 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1435356003653 SWIM zinc finger; Region: SWIM; pfam04434 1435356003654 MoxR-like ATPases [General function prediction only]; Region: COG0714 1435356003655 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 1435356003656 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 1435356003657 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1435356003658 metal ion-dependent adhesion site (MIDAS); other site 1435356003659 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356003660 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356003661 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1435356003662 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1435356003663 siderophore binding site; other site 1435356003664 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 1435356003665 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1435356003666 catalytic loop [active] 1435356003667 iron binding site [ion binding]; other site 1435356003668 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 1435356003669 L-aspartate oxidase; Provisional; Region: PRK06175 1435356003670 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1435356003671 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1435356003672 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1435356003673 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1435356003674 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1435356003675 catalytic residue [active] 1435356003676 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1435356003677 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 1435356003678 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1435356003679 inhibitor-cofactor binding pocket; inhibition site 1435356003680 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1435356003681 catalytic residue [active] 1435356003682 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1435356003683 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1435356003684 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1435356003685 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1435356003686 active site 1435356003687 catalytic site [active] 1435356003688 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 1435356003689 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1435356003690 active site 1435356003691 catalytic site [active] 1435356003692 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1435356003693 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1435356003694 non-specific DNA binding site [nucleotide binding]; other site 1435356003695 salt bridge; other site 1435356003696 sequence-specific DNA binding site [nucleotide binding]; other site 1435356003697 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1435356003698 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1435356003699 hypothetical protein; Provisional; Region: PRK04233 1435356003700 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356003701 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356003702 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1435356003703 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1435356003704 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1435356003705 catalytic site [active] 1435356003706 active site 1435356003707 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1435356003708 threonine dehydratase; Validated; Region: PRK08639 1435356003709 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1435356003710 tetramer interface [polypeptide binding]; other site 1435356003711 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1435356003712 catalytic residue [active] 1435356003713 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1435356003714 putative Ile/Val binding site [chemical binding]; other site 1435356003715 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1435356003716 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1435356003717 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1435356003718 active site 1435356003719 PHP Thumb interface [polypeptide binding]; other site 1435356003720 metal binding site [ion binding]; metal-binding site 1435356003721 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1435356003722 generic binding surface II; other site 1435356003723 generic binding surface I; other site 1435356003724 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1435356003725 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1435356003726 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1435356003727 active site 1435356003728 lipoprotein signal peptidase; Provisional; Region: PRK14764 1435356003729 siroheme synthase, N-terminal domain; Region: cysG_Nterm; TIGR01470 1435356003730 DNA polymerase IV; Provisional; Region: PRK03348 1435356003731 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1435356003732 active site 1435356003733 DNA binding site [nucleotide binding] 1435356003734 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 1435356003735 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1435356003736 HIGH motif; other site 1435356003737 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1435356003738 active site 1435356003739 KMSKS motif; other site 1435356003740 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1435356003741 tRNA binding surface [nucleotide binding]; other site 1435356003742 anticodon binding site; other site 1435356003743 DivIVA domain; Region: DivI1A_domain; TIGR03544 1435356003744 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1435356003745 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1435356003746 Predicted integral membrane protein [Function unknown]; Region: COG0762 1435356003747 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1435356003748 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1435356003749 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1435356003750 catalytic residue [active] 1435356003751 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1435356003752 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1435356003753 cell division protein FtsZ; Validated; Region: PRK09330 1435356003754 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1435356003755 nucleotide binding site [chemical binding]; other site 1435356003756 SulA interaction site; other site 1435356003757 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1435356003758 Cell division protein FtsQ; Region: FtsQ; pfam03799 1435356003759 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1435356003760 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1435356003761 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1435356003762 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1435356003763 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1435356003764 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1435356003765 active site 1435356003766 homodimer interface [polypeptide binding]; other site 1435356003767 cell division protein FtsW; Region: ftsW; TIGR02614 1435356003768 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 1435356003769 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; pfam01488 1435356003770 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1435356003771 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1435356003772 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1435356003773 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1435356003774 Mg++ binding site [ion binding]; other site 1435356003775 putative catalytic motif [active] 1435356003776 putative substrate binding site [chemical binding]; other site 1435356003777 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1435356003778 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1435356003779 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1435356003780 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1435356003781 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1435356003782 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1435356003783 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1435356003784 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1435356003785 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1435356003786 MraW methylase family; Region: Methyltransf_5; cl17771 1435356003787 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1435356003788 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 1435356003789 MraZ protein; Region: MraZ; pfam02381 1435356003790 MraZ protein; Region: MraZ; pfam02381 1435356003791 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 1435356003792 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1435356003793 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1435356003794 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1435356003795 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1435356003796 Protein of unknown function (DUF422); Region: DUF422; cl00991 1435356003797 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 1435356003798 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1435356003799 active site 1435356003800 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1435356003801 FAD binding site [chemical binding]; other site 1435356003802 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1435356003803 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1435356003804 substrate binding pocket [chemical binding]; other site 1435356003805 chain length determination region; other site 1435356003806 substrate-Mg2+ binding site; other site 1435356003807 catalytic residues [active] 1435356003808 aspartate-rich region 1; other site 1435356003809 active site lid residues [active] 1435356003810 aspartate-rich region 2; other site 1435356003811 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1435356003812 phytoene desaturase; Region: crtI_fam; TIGR02734 1435356003813 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1435356003814 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1435356003815 active site lid residues [active] 1435356003816 substrate binding pocket [chemical binding]; other site 1435356003817 catalytic residues [active] 1435356003818 substrate-Mg2+ binding site; other site 1435356003819 aspartate-rich region 1; other site 1435356003820 aspartate-rich region 2; other site 1435356003821 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1435356003822 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1435356003823 active site 1435356003824 ATP binding site [chemical binding]; other site 1435356003825 substrate binding site [chemical binding]; other site 1435356003826 activation loop (A-loop); other site 1435356003827 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1435356003828 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1435356003829 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1435356003830 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1435356003831 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1435356003832 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1435356003833 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1435356003834 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1435356003835 putative acyl-acceptor binding pocket; other site 1435356003836 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1435356003837 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1435356003838 nucleotide binding site [chemical binding]; other site 1435356003839 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1435356003840 transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345 1435356003841 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1435356003842 putative hydrophobic ligand binding site [chemical binding]; other site 1435356003843 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1435356003844 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1435356003845 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1435356003846 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1435356003847 NlpC/P60 family; Region: NLPC_P60; pfam00877 1435356003848 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1435356003849 NlpC/P60 family; Region: NLPC_P60; pfam00877 1435356003850 hypothetical protein; Validated; Region: PRK07883 1435356003851 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1435356003852 active site 1435356003853 catalytic site [active] 1435356003854 substrate binding site [chemical binding]; other site 1435356003855 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1435356003856 GIY-YIG motif/motif A; other site 1435356003857 active site 1435356003858 catalytic site [active] 1435356003859 putative DNA binding site [nucleotide binding]; other site 1435356003860 metal binding site [ion binding]; metal-binding site 1435356003861 AsnC family; Region: AsnC_trans_reg; pfam01037 1435356003862 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1435356003863 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1435356003864 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1435356003865 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216 1435356003866 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1435356003867 Subunit I/III interface [polypeptide binding]; other site 1435356003868 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1435356003869 Cytochrome c; Region: Cytochrom_C; pfam00034 1435356003870 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1435356003871 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1435356003872 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 1435356003873 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1435356003874 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1435356003875 iron-sulfur cluster [ion binding]; other site 1435356003876 [2Fe-2S] cluster binding site [ion binding]; other site 1435356003877 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1435356003878 heme bH binding site [chemical binding]; other site 1435356003879 intrachain domain interface; other site 1435356003880 heme bL binding site [chemical binding]; other site 1435356003881 interchain domain interface [polypeptide binding]; other site 1435356003882 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 1435356003883 Qo binding site; other site 1435356003884 HEAT repeats; Region: HEAT_2; pfam13646 1435356003885 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 1435356003886 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1435356003887 DNA binding residues [nucleotide binding] 1435356003888 putative dimer interface [polypeptide binding]; other site 1435356003889 HEAT repeats; Region: HEAT_2; pfam13646 1435356003890 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 1435356003891 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140 1435356003892 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1435356003893 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1435356003894 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1435356003895 active site 1435356003896 dimer interface [polypeptide binding]; other site 1435356003897 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1435356003898 Ligand Binding Site [chemical binding]; other site 1435356003899 Molecular Tunnel; other site 1435356003900 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 1435356003901 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1435356003902 substrate binding site [chemical binding]; other site 1435356003903 ATP binding site [chemical binding]; other site 1435356003904 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 1435356003905 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 1435356003906 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1435356003907 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1435356003908 putative dimer interface [polypeptide binding]; other site 1435356003909 active site pocket [active] 1435356003910 putative cataytic base [active] 1435356003911 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1435356003912 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1435356003913 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1435356003914 homodimer interface [polypeptide binding]; other site 1435356003915 substrate-cofactor binding pocket; other site 1435356003916 catalytic residue [active] 1435356003917 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1435356003918 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1435356003919 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1435356003920 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1435356003921 interface (dimer of trimers) [polypeptide binding]; other site 1435356003922 Substrate-binding/catalytic site; other site 1435356003923 Zn-binding sites [ion binding]; other site 1435356003924 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; Region: SucB_Actino; TIGR02927 1435356003925 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1435356003926 E3 interaction surface; other site 1435356003927 lipoyl attachment site [posttranslational modification]; other site 1435356003928 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1435356003929 E3 interaction surface; other site 1435356003930 lipoyl attachment site [posttranslational modification]; other site 1435356003931 e3 binding domain; Region: E3_binding; pfam02817 1435356003932 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1435356003933 lipoate-protein ligase B; Provisional; Region: PRK14345 1435356003934 lipoyl synthase; Provisional; Region: PRK05481 1435356003935 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1435356003936 FeS/SAM binding site; other site 1435356003937 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1435356003938 RDD family; Region: RDD; pfam06271 1435356003939 glutamine synthetase, type I; Region: GlnA; TIGR00653 1435356003940 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1435356003941 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1435356003942 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1435356003943 metal binding site 2 [ion binding]; metal-binding site 1435356003944 putative DNA binding helix; other site 1435356003945 metal binding site 1 [ion binding]; metal-binding site 1435356003946 dimer interface [polypeptide binding]; other site 1435356003947 structural Zn2+ binding site [ion binding]; other site 1435356003948 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 1435356003949 dimer interface [polypeptide binding]; other site 1435356003950 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1435356003951 active site 1435356003952 heme binding site [chemical binding]; other site 1435356003953 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1435356003954 Pleckstrin homology-like domain; Region: PH-like; cl17171 1435356003955 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 1435356003956 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1435356003957 metal binding triad; other site 1435356003958 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1435356003959 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1435356003960 metal binding triad; other site 1435356003961 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1435356003962 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1435356003963 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1435356003964 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1435356003965 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1435356003966 TAP-like protein; Region: Abhydrolase_4; pfam08386 1435356003967 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1435356003968 oligomerization interface [polypeptide binding]; other site 1435356003969 active site 1435356003970 metal binding site [ion binding]; metal-binding site 1435356003971 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1435356003972 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1435356003973 TAP-like protein; Region: Abhydrolase_4; pfam08386 1435356003974 Uncharacterized protein conserved in bacteria (DUF2272); Region: DUF2272; cl01776 1435356003975 RNB domain; Region: RNB; pfam00773 1435356003976 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 1435356003977 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 1435356003978 Secretory lipase; Region: LIP; pfam03583 1435356003979 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 1435356003980 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1435356003981 RNA/DNA hybrid binding site [nucleotide binding]; other site 1435356003982 active site 1435356003983 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1435356003984 catalytic core [active] 1435356003985 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1435356003986 Putative zinc ribbon domain; Region: DUF164; pfam02591 1435356003987 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1435356003988 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1435356003989 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1435356003990 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1435356003991 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1435356003992 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1435356003993 motif II; other site 1435356003994 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1435356003995 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1435356003996 active site 1435356003997 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1435356003998 Uncharacterized conserved protein [Function unknown]; Region: COG3586 1435356003999 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1435356004000 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 1435356004001 dimer interface [polypeptide binding]; other site 1435356004002 catalytic triad [active] 1435356004003 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 1435356004004 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1435356004005 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1435356004006 dimer interface [polypeptide binding]; other site 1435356004007 TPP-binding site [chemical binding]; other site 1435356004008 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1435356004009 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1435356004010 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1435356004011 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1435356004012 acyl carrier protein; Provisional; Region: acpP; PRK00982 1435356004013 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 1435356004014 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1435356004015 dimer interface [polypeptide binding]; other site 1435356004016 active site 1435356004017 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 1435356004018 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1435356004019 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1435356004020 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 1435356004021 Beta-lactamase; Region: Beta-lactamase; pfam00144 1435356004022 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1435356004023 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1435356004024 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1435356004025 NAD binding site [chemical binding]; other site 1435356004026 catalytic Zn binding site [ion binding]; other site 1435356004027 substrate binding site [chemical binding]; other site 1435356004028 structural Zn binding site [ion binding]; other site 1435356004029 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 1435356004030 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1435356004031 Beta-Casp domain; Region: Beta-Casp; smart01027 1435356004032 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1435356004033 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1435356004034 putative catalytic site [active] 1435356004035 putative phosphate binding site [ion binding]; other site 1435356004036 putative metal binding site [ion binding]; other site 1435356004037 Predicted transcriptional regulator [Transcription]; Region: COG2378 1435356004038 HTH domain; Region: HTH_11; pfam08279 1435356004039 WYL domain; Region: WYL; pfam13280 1435356004040 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1435356004041 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 1435356004042 putative dimer interface [polypeptide binding]; other site 1435356004043 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1435356004044 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 1435356004045 Thioredoxin; Region: Thioredoxin_4; pfam13462 1435356004046 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1435356004047 DNA primase; Validated; Region: dnaG; PRK05667 1435356004048 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1435356004049 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1435356004050 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1435356004051 active site 1435356004052 metal binding site [ion binding]; metal-binding site 1435356004053 interdomain interaction site; other site 1435356004054 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1435356004055 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 1435356004056 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 1435356004057 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1435356004058 Zn2+ binding site [ion binding]; other site 1435356004059 Mg2+ binding site [ion binding]; other site 1435356004060 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1435356004061 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1435356004062 putative active site [active] 1435356004063 Repair protein; Region: Repair_PSII; pfam04536 1435356004064 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1435356004065 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1435356004066 motif 1; other site 1435356004067 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1435356004068 active site 1435356004069 motif 2; other site 1435356004070 motif 3; other site 1435356004071 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1435356004072 anticodon binding site; other site 1435356004073 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1435356004074 dimerization interface [polypeptide binding]; other site 1435356004075 putative DNA binding site [nucleotide binding]; other site 1435356004076 putative Zn2+ binding site [ion binding]; other site 1435356004077 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1435356004078 metal binding site 2 [ion binding]; metal-binding site 1435356004079 putative DNA binding helix; other site 1435356004080 metal binding site 1 [ion binding]; metal-binding site 1435356004081 dimer interface [polypeptide binding]; other site 1435356004082 structural Zn2+ binding site [ion binding]; other site 1435356004083 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1435356004084 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1435356004085 catalytic residue [active] 1435356004086 putative FPP diphosphate binding site; other site 1435356004087 putative FPP binding hydrophobic cleft; other site 1435356004088 dimer interface [polypeptide binding]; other site 1435356004089 putative IPP diphosphate binding site; other site 1435356004090 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1435356004091 Recombination protein O N terminal; Region: RecO_N; pfam11967 1435356004092 Recombination protein O C terminal; Region: RecO_C; pfam02565 1435356004093 amidase; Provisional; Region: PRK06061 1435356004094 Amidase; Region: Amidase; cl11426 1435356004095 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356004096 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356004097 GTPase Era; Reviewed; Region: era; PRK00089 1435356004098 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1435356004099 G1 box; other site 1435356004100 GTP/Mg2+ binding site [chemical binding]; other site 1435356004101 Switch I region; other site 1435356004102 G2 box; other site 1435356004103 Switch II region; other site 1435356004104 G3 box; other site 1435356004105 G4 box; other site 1435356004106 G5 box; other site 1435356004107 KH domain; Region: KH_2; pfam07650 1435356004108 Domain of unknown function DUF21; Region: DUF21; pfam01595 1435356004109 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1435356004110 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1435356004111 Transporter associated domain; Region: CorC_HlyC; smart01091 1435356004112 metal-binding heat shock protein; Provisional; Region: PRK00016 1435356004113 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1435356004114 PhoH-like protein; Region: PhoH; pfam02562 1435356004115 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356004116 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356004117 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1435356004118 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356004119 Dienelactone hydrolase family; Region: DLH; pfam01738 1435356004120 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1435356004121 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1435356004122 RNA methyltransferase, RsmE family; Region: TIGR00046 1435356004123 chaperone protein DnaJ; Provisional; Region: PRK14278 1435356004124 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1435356004125 HSP70 interaction site [polypeptide binding]; other site 1435356004126 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1435356004127 Zn binding sites [ion binding]; other site 1435356004128 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1435356004129 dimer interface [polypeptide binding]; other site 1435356004130 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1435356004131 HTH domain; Region: HTH_11; cl17392 1435356004132 Ribosomal protein S19e; Region: Ribosomal_S19e; cl00969 1435356004133 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1435356004134 coproporphyrinogen III oxidase; Validated; Region: PRK05628 1435356004135 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1435356004136 FeS/SAM binding site; other site 1435356004137 HemN C-terminal domain; Region: HemN_C; pfam06969 1435356004138 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1435356004139 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1435356004140 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1435356004141 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1435356004142 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1435356004143 Active Sites [active] 1435356004144 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1435356004145 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1435356004146 Active Sites [active] 1435356004147 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 1435356004148 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1435356004149 CysD dimerization site [polypeptide binding]; other site 1435356004150 G1 box; other site 1435356004151 putative GEF interaction site [polypeptide binding]; other site 1435356004152 GTP/Mg2+ binding site [chemical binding]; other site 1435356004153 Switch I region; other site 1435356004154 G2 box; other site 1435356004155 G3 box; other site 1435356004156 Switch II region; other site 1435356004157 G4 box; other site 1435356004158 G5 box; other site 1435356004159 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1435356004160 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1435356004161 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1435356004162 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1435356004163 putative active site [active] 1435356004164 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 1435356004165 active site 1435356004166 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1435356004167 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1435356004168 Ligand Binding Site [chemical binding]; other site 1435356004169 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1435356004170 Ligand Binding Site [chemical binding]; other site 1435356004171 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 1435356004172 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1435356004173 Walker A/P-loop; other site 1435356004174 ATP binding site [chemical binding]; other site 1435356004175 Q-loop/lid; other site 1435356004176 ABC transporter signature motif; other site 1435356004177 Walker B; other site 1435356004178 D-loop; other site 1435356004179 H-loop/switch region; other site 1435356004180 TOBE-like domain; Region: TOBE_3; pfam12857 1435356004181 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1435356004182 dimer interface [polypeptide binding]; other site 1435356004183 conserved gate region; other site 1435356004184 putative PBP binding loops; other site 1435356004185 ABC-ATPase subunit interface; other site 1435356004186 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1435356004187 dimer interface [polypeptide binding]; other site 1435356004188 conserved gate region; other site 1435356004189 putative PBP binding loops; other site 1435356004190 ABC-ATPase subunit interface; other site 1435356004191 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1435356004192 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1435356004193 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1435356004194 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1435356004195 Nitronate monooxygenase; Region: NMO; pfam03060 1435356004196 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1435356004197 FMN binding site [chemical binding]; other site 1435356004198 substrate binding site [chemical binding]; other site 1435356004199 putative catalytic residue [active] 1435356004200 GTP-binding protein LepA; Provisional; Region: PRK05433 1435356004201 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1435356004202 G1 box; other site 1435356004203 putative GEF interaction site [polypeptide binding]; other site 1435356004204 GTP/Mg2+ binding site [chemical binding]; other site 1435356004205 Switch I region; other site 1435356004206 G2 box; other site 1435356004207 G3 box; other site 1435356004208 Switch II region; other site 1435356004209 G4 box; other site 1435356004210 G5 box; other site 1435356004211 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1435356004212 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1435356004213 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1435356004214 PemK-like protein; Region: PemK; pfam02452 1435356004215 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 1435356004216 amphipathic channel; other site 1435356004217 Asn-Pro-Ala signature motifs; other site 1435356004218 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1435356004219 hypothetical protein; Reviewed; Region: PRK07914 1435356004220 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1435356004221 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1435356004222 Competence protein; Region: Competence; pfam03772 1435356004223 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1435356004224 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1435356004225 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1435356004226 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1435356004227 EDD domain protein, DegV family; Region: DegV; TIGR00762 1435356004228 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1435356004229 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1435356004230 active site 1435356004231 catalytic triad [active] 1435356004232 oxyanion hole [active] 1435356004233 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1435356004234 catalytic core [active] 1435356004235 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1435356004236 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1435356004237 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1435356004238 active site 1435356004239 (T/H)XGH motif; other site 1435356004240 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 1435356004241 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 1435356004242 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1435356004243 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1435356004244 Walker A motif; other site 1435356004245 ATP binding site [chemical binding]; other site 1435356004246 Walker B motif; other site 1435356004247 arginine finger; other site 1435356004248 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1435356004249 putative catalytic cysteine [active] 1435356004250 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1435356004251 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1435356004252 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1435356004253 cystathionine gamma-lyase; Validated; Region: PRK07582 1435356004254 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1435356004255 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1435356004256 catalytic residue [active] 1435356004257 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1435356004258 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1435356004259 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1435356004260 2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552 1435356004261 polyphosphate kinase; Provisional; Region: PRK05443 1435356004262 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1435356004263 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1435356004264 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1435356004265 putative domain interface [polypeptide binding]; other site 1435356004266 putative active site [active] 1435356004267 catalytic site [active] 1435356004268 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1435356004269 putative domain interface [polypeptide binding]; other site 1435356004270 putative active site [active] 1435356004271 catalytic site [active] 1435356004272 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1435356004273 active site 1435356004274 Ap6A binding site [chemical binding]; other site 1435356004275 nudix motif; other site 1435356004276 metal binding site [ion binding]; metal-binding site 1435356004277 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1435356004278 catalytic core [active] 1435356004279 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1435356004280 IHF - DNA interface [nucleotide binding]; other site 1435356004281 IHF dimer interface [polypeptide binding]; other site 1435356004282 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1435356004283 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1435356004284 substrate binding site [chemical binding]; other site 1435356004285 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1435356004286 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1435356004287 substrate binding site [chemical binding]; other site 1435356004288 ligand binding site [chemical binding]; other site 1435356004289 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1435356004290 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1435356004291 Bacterial transcriptional regulator; Region: IclR; pfam01614 1435356004292 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1435356004293 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1435356004294 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1435356004295 HIGH motif; other site 1435356004296 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1435356004297 active site 1435356004298 KMSKS motif; other site 1435356004299 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1435356004300 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1435356004301 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1435356004302 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356004303 putative substrate translocation pore; other site 1435356004304 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1435356004305 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 1435356004306 tartrate dehydrogenase; Region: TTC; TIGR02089 1435356004307 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1435356004308 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1435356004309 ligand binding site [chemical binding]; other site 1435356004310 NAD binding site [chemical binding]; other site 1435356004311 dimerization interface [polypeptide binding]; other site 1435356004312 catalytic site [active] 1435356004313 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1435356004314 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1435356004315 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1435356004316 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1435356004317 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1435356004318 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1435356004319 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1435356004320 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1435356004321 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1435356004322 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1435356004323 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1435356004324 putative valine binding site [chemical binding]; other site 1435356004325 dimer interface [polypeptide binding]; other site 1435356004326 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1435356004327 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 1435356004328 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1435356004329 PYR/PP interface [polypeptide binding]; other site 1435356004330 dimer interface [polypeptide binding]; other site 1435356004331 TPP binding site [chemical binding]; other site 1435356004332 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1435356004333 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1435356004334 TPP-binding site [chemical binding]; other site 1435356004335 dimer interface [polypeptide binding]; other site 1435356004336 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1435356004337 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1435356004338 Predicted membrane protein [Function unknown]; Region: COG2259 1435356004339 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1435356004340 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1435356004341 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1435356004342 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1435356004343 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1435356004344 GatB domain; Region: GatB_Yqey; smart00845 1435356004345 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1435356004346 phosphofructokinase; Region: PFK_mixed; TIGR02483 1435356004347 active site 1435356004348 ADP/pyrophosphate binding site [chemical binding]; other site 1435356004349 dimerization interface [polypeptide binding]; other site 1435356004350 allosteric effector site; other site 1435356004351 fructose-1,6-bisphosphate binding site; other site 1435356004352 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1435356004353 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1435356004354 active site 1435356004355 phosphorylation site [posttranslational modification] 1435356004356 intermolecular recognition site; other site 1435356004357 dimerization interface [polypeptide binding]; other site 1435356004358 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1435356004359 DNA binding residues [nucleotide binding] 1435356004360 dimerization interface [polypeptide binding]; other site 1435356004361 Histidine kinase; Region: HisKA_3; pfam07730 1435356004362 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1435356004363 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 1435356004364 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1435356004365 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1435356004366 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1435356004367 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1435356004368 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1435356004369 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1435356004370 DNA binding residues [nucleotide binding] 1435356004371 dimerization interface [polypeptide binding]; other site 1435356004372 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1435356004373 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 1435356004374 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1435356004375 catalytic residue [active] 1435356004376 Predicted membrane protein [Function unknown]; Region: COG1511 1435356004377 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1435356004378 Predicted membrane protein [Function unknown]; Region: COG1511 1435356004379 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1435356004380 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1435356004381 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1435356004382 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1435356004383 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1435356004384 active site 1435356004385 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1435356004386 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1435356004387 nucleotide binding pocket [chemical binding]; other site 1435356004388 K-X-D-G motif; other site 1435356004389 catalytic site [active] 1435356004390 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1435356004391 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1435356004392 Helix-hairpin-helix motif; Region: HHH; pfam00633 1435356004393 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1435356004394 Dimer interface [polypeptide binding]; other site 1435356004395 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 1435356004396 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1435356004397 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1435356004398 Ligand Binding Site [chemical binding]; other site 1435356004399 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1435356004400 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1435356004401 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1435356004402 catalytic residue [active] 1435356004403 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1435356004404 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1435356004405 putative acyl-acceptor binding pocket; other site 1435356004406 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 1435356004407 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1435356004408 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1435356004409 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1435356004410 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1435356004411 Ligand binding site [chemical binding]; other site 1435356004412 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1435356004413 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1435356004414 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1435356004415 S-adenosylmethionine binding site [chemical binding]; other site 1435356004416 Uncharacterized conserved protein [Function unknown]; Region: COG1543 1435356004417 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1435356004418 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 1435356004419 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1435356004420 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1435356004421 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1435356004422 Coenzyme A binding pocket [chemical binding]; other site 1435356004423 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1435356004424 Amidase; Region: Amidase; cl11426 1435356004425 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1435356004426 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1435356004427 trimer interface [polypeptide binding]; other site 1435356004428 active site 1435356004429 substrate binding site [chemical binding]; other site 1435356004430 CoA binding site [chemical binding]; other site 1435356004431 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1435356004432 Trp docking motif [polypeptide binding]; other site 1435356004433 PQQ-like domain; Region: PQQ_2; pfam13360 1435356004434 active site 1435356004435 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1435356004436 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1435356004437 S-adenosylmethionine binding site [chemical binding]; other site 1435356004438 enoyl-CoA hydratase; Provisional; Region: PRK05862 1435356004439 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1435356004440 substrate binding site [chemical binding]; other site 1435356004441 oxyanion hole (OAH) forming residues; other site 1435356004442 trimer interface [polypeptide binding]; other site 1435356004443 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1435356004444 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1435356004445 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1435356004446 Walker A/P-loop; other site 1435356004447 Walker A/P-loop; other site 1435356004448 ATP binding site [chemical binding]; other site 1435356004449 ATP binding site [chemical binding]; other site 1435356004450 Q-loop/lid; other site 1435356004451 ABC transporter signature motif; other site 1435356004452 Walker B; other site 1435356004453 D-loop; other site 1435356004454 H-loop/switch region; other site 1435356004455 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1435356004456 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1435356004457 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1435356004458 active site 1435356004459 catalytic site [active] 1435356004460 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 1435356004461 dimer interface [polypeptide binding]; other site 1435356004462 putative active site [active] 1435356004463 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 1435356004464 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 1435356004465 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1435356004466 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1435356004467 motif II; other site 1435356004468 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1435356004469 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1435356004470 D-pathway; other site 1435356004471 Putative ubiquinol binding site [chemical binding]; other site 1435356004472 Low-spin heme (heme b) binding site [chemical binding]; other site 1435356004473 Putative water exit pathway; other site 1435356004474 Binuclear center (heme o3/CuB) [ion binding]; other site 1435356004475 K-pathway; other site 1435356004476 Putative proton exit pathway; other site 1435356004477 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1435356004478 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1435356004479 siderophore binding site; other site 1435356004480 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1435356004481 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1435356004482 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 1435356004483 nudix motif; other site 1435356004484 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1435356004485 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1435356004486 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1435356004487 dimer interface [polypeptide binding]; other site 1435356004488 putative radical transfer pathway; other site 1435356004489 diiron center [ion binding]; other site 1435356004490 tyrosyl radical; other site 1435356004491 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1435356004492 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1435356004493 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1435356004494 active site 1435356004495 dimer interface [polypeptide binding]; other site 1435356004496 catalytic residues [active] 1435356004497 effector binding site; other site 1435356004498 R2 peptide binding site; other site 1435356004499 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1435356004500 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1435356004501 catalytic residues [active] 1435356004502 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 1435356004503 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1435356004504 GAF domain; Region: GAF; pfam01590 1435356004505 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1435356004506 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1435356004507 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 1435356004508 DXD motif; other site 1435356004509 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1435356004510 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1435356004511 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1435356004512 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1435356004513 anti sigma factor interaction site; other site 1435356004514 regulatory phosphorylation site [posttranslational modification]; other site 1435356004515 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1435356004516 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1435356004517 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1435356004518 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1435356004519 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1435356004520 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1435356004521 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1435356004522 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1435356004523 catalytic loop [active] 1435356004524 iron binding site [ion binding]; other site 1435356004525 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1435356004526 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1435356004527 Predicted flavoprotein [General function prediction only]; Region: COG0431 1435356004528 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356004529 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356004530 META domain; Region: META; pfam03724 1435356004531 META domain; Region: META; pfam03724 1435356004532 META domain; Region: META; pfam03724 1435356004533 nucleosidase; Provisional; Region: PRK05634 1435356004534 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 1435356004535 Fructosamine kinase; Region: Fructosamin_kin; cl17579 1435356004536 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1435356004537 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1435356004538 homodimer interface [polypeptide binding]; other site 1435356004539 NAD binding pocket [chemical binding]; other site 1435356004540 ATP binding pocket [chemical binding]; other site 1435356004541 Mg binding site [ion binding]; other site 1435356004542 active-site loop [active] 1435356004543 Ubiquitin-like proteins; Region: UBQ; cl00155 1435356004544 charged pocket; other site 1435356004545 hydrophobic patch; other site 1435356004546 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1435356004547 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1435356004548 FeS/SAM binding site; other site 1435356004549 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1435356004550 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1435356004551 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1435356004552 dimer interface [polypeptide binding]; other site 1435356004553 putative functional site; other site 1435356004554 putative MPT binding site; other site 1435356004555 molybdenum cofactor biosynthesis protein MoaC; Provisional; Region: moaC; PRK09364 1435356004556 bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional; Region: moaC; PRK03604 1435356004557 trimer interface [polypeptide binding]; other site 1435356004558 dimer interface [polypeptide binding]; other site 1435356004559 putative active site [active] 1435356004560 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1435356004561 MPT binding site; other site 1435356004562 trimer interface [polypeptide binding]; other site 1435356004563 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1435356004564 MoaE homodimer interface [polypeptide binding]; other site 1435356004565 MoaD interaction [polypeptide binding]; other site 1435356004566 active site residues [active] 1435356004567 helicase 45; Provisional; Region: PTZ00424 1435356004568 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1435356004569 ATP binding site [chemical binding]; other site 1435356004570 Mg++ binding site [ion binding]; other site 1435356004571 motif III; other site 1435356004572 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1435356004573 nucleotide binding region [chemical binding]; other site 1435356004574 ATP-binding site [chemical binding]; other site 1435356004575 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1435356004576 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1435356004577 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1435356004578 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1435356004579 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 1435356004580 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1435356004581 NAD binding site [chemical binding]; other site 1435356004582 catalytic Zn binding site [ion binding]; other site 1435356004583 substrate binding site [chemical binding]; other site 1435356004584 structural Zn binding site [ion binding]; other site 1435356004585 Cutinase; Region: Cutinase; pfam01083 1435356004586 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1435356004587 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1435356004588 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1435356004589 DNA binding residues [nucleotide binding] 1435356004590 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1435356004591 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1435356004592 acyl-activating enzyme (AAE) consensus motif; other site 1435356004593 putative active site [active] 1435356004594 putative AMP binding site [chemical binding]; other site 1435356004595 putative CoA binding site [chemical binding]; other site 1435356004596 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1435356004597 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1435356004598 FAD binding pocket [chemical binding]; other site 1435356004599 FAD binding motif [chemical binding]; other site 1435356004600 phosphate binding motif [ion binding]; other site 1435356004601 NAD binding pocket [chemical binding]; other site 1435356004602 O-methyltransferase; Region: Methyltransf_2; pfam00891 1435356004603 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356004604 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356004605 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293 1435356004606 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1435356004607 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1435356004608 myosin-cross-reactive antigen; Provisional; Region: PRK13977 1435356004609 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 1435356004610 conserved cys residue [active] 1435356004611 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1435356004612 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1435356004613 catalytic residues [active] 1435356004614 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356004615 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1435356004616 putative substrate translocation pore; other site 1435356004617 phosphoglucomutase; Validated; Region: PRK07564 1435356004618 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1435356004619 active site 1435356004620 substrate binding site [chemical binding]; other site 1435356004621 metal binding site [ion binding]; metal-binding site 1435356004622 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1435356004623 SmpB-tmRNA interface; other site 1435356004624 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1435356004625 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1435356004626 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1435356004627 Walker A/P-loop; other site 1435356004628 ATP binding site [chemical binding]; other site 1435356004629 Q-loop/lid; other site 1435356004630 ABC transporter signature motif; other site 1435356004631 Walker B; other site 1435356004632 D-loop; other site 1435356004633 H-loop/switch region; other site 1435356004634 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1435356004635 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1435356004636 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1435356004637 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1435356004638 RF-1 domain; Region: RF-1; pfam00472 1435356004639 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1435356004640 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1435356004641 active site 1435356004642 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1435356004643 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1435356004644 active site 1435356004645 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1435356004646 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1435356004647 active site 1435356004648 acyl-CoA synthetase; Validated; Region: PRK07788 1435356004649 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1435356004650 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1435356004651 acyl-activating enzyme (AAE) consensus motif; other site 1435356004652 putative AMP binding site [chemical binding]; other site 1435356004653 putative active site [active] 1435356004654 putative CoA binding site [chemical binding]; other site 1435356004655 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1435356004656 hypothetical protein; Provisional; Region: PRK12438 1435356004657 hypothetical protein; Validated; Region: PRK00068 1435356004658 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1435356004659 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1435356004660 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1435356004661 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1435356004662 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 1435356004663 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 1435356004664 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1435356004665 ABC1 family; Region: ABC1; pfam03109 1435356004666 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1435356004667 active site 1435356004668 ATP binding site [chemical binding]; other site 1435356004669 Transcription factor WhiB; Region: Whib; pfam02467 1435356004670 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1435356004671 Family description; Region: UvrD_C_2; pfam13538 1435356004672 HRDC domain; Region: HRDC; pfam00570 1435356004673 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1435356004674 catalytic residues [active] 1435356004675 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1435356004676 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1435356004677 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1435356004678 putative NADH binding site [chemical binding]; other site 1435356004679 putative active site [active] 1435356004680 nudix motif; other site 1435356004681 putative metal binding site [ion binding]; other site 1435356004682 Ion channel; Region: Ion_trans_2; pfam07885 1435356004683 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 1435356004684 TrkA-N domain; Region: TrkA_N; pfam02254 1435356004685 Predicted membrane protein [Function unknown]; Region: COG4270 1435356004686 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1435356004687 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1435356004688 NAD(P) binding site [chemical binding]; other site 1435356004689 active site 1435356004690 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1435356004691 Part of AAA domain; Region: AAA_19; pfam13245 1435356004692 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1435356004693 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1435356004694 Part of AAA domain; Region: AAA_19; pfam13245 1435356004695 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1435356004696 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1435356004697 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1435356004698 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1435356004699 catalytic site [active] 1435356004700 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1435356004701 DNA binding site [nucleotide binding] 1435356004702 active site 1435356004703 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 1435356004704 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1435356004705 Walker A/P-loop; other site 1435356004706 ATP binding site [chemical binding]; other site 1435356004707 Q-loop/lid; other site 1435356004708 ABC transporter signature motif; other site 1435356004709 Walker B; other site 1435356004710 D-loop; other site 1435356004711 H-loop/switch region; other site 1435356004712 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1435356004713 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1435356004714 GTP binding site; other site 1435356004715 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1435356004716 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1435356004717 dimer interface [polypeptide binding]; other site 1435356004718 putative functional site; other site 1435356004719 putative MPT binding site; other site 1435356004720 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1435356004721 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1435356004722 putative active site [active] 1435356004723 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1435356004724 putative active site [active] 1435356004725 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 1435356004726 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1435356004727 active site 1435356004728 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1435356004729 DNA binding site [nucleotide binding] 1435356004730 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1435356004731 nitrite reductase subunit NirD; Provisional; Region: PRK14989 1435356004732 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1435356004733 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1435356004734 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1435356004735 TIGR02569 family protein; Region: TIGR02569_actnb 1435356004736 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 1435356004737 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1435356004738 ATP binding site [chemical binding]; other site 1435356004739 substrate interface [chemical binding]; other site 1435356004740 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1435356004741 active site residue [active] 1435356004742 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 1435356004743 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356004744 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356004745 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 1435356004746 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1435356004747 dinuclear metal binding motif [ion binding]; other site 1435356004748 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 1435356004749 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1435356004750 ATP binding site [chemical binding]; other site 1435356004751 Mg++ binding site [ion binding]; other site 1435356004752 motif III; other site 1435356004753 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1435356004754 nucleotide binding region [chemical binding]; other site 1435356004755 ATP-binding site [chemical binding]; other site 1435356004756 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1435356004757 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1435356004758 P-loop; other site 1435356004759 Magnesium ion binding site [ion binding]; other site 1435356004760 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1435356004761 Magnesium ion binding site [ion binding]; other site 1435356004762 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1435356004763 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1435356004764 Coenzyme A binding pocket [chemical binding]; other site 1435356004765 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1435356004766 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1435356004767 Transcription factor WhiB; Region: Whib; pfam02467 1435356004768 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 1435356004769 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1435356004770 PAS fold; Region: PAS_4; pfam08448 1435356004771 putative active site [active] 1435356004772 heme pocket [chemical binding]; other site 1435356004773 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1435356004774 Histidine kinase; Region: HisKA_2; pfam07568 1435356004775 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1435356004776 ATP binding site [chemical binding]; other site 1435356004777 Mg2+ binding site [ion binding]; other site 1435356004778 G-X-G motif; other site 1435356004779 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1435356004780 carboxyltransferase (CT) interaction site; other site 1435356004781 biotinylation site [posttranslational modification]; other site 1435356004782 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 1435356004783 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 1435356004784 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1435356004785 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1435356004786 DNA binding residues [nucleotide binding] 1435356004787 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1435356004788 putative deacylase active site [active] 1435356004789 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 1435356004790 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1435356004791 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1435356004792 hinge; other site 1435356004793 active site 1435356004794 Predicted GTPases [General function prediction only]; Region: COG1162 1435356004795 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1435356004796 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1435356004797 GTP/Mg2+ binding site [chemical binding]; other site 1435356004798 G4 box; other site 1435356004799 G1 box; other site 1435356004800 Switch I region; other site 1435356004801 G2 box; other site 1435356004802 G3 box; other site 1435356004803 Switch II region; other site 1435356004804 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1435356004805 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1435356004806 putative di-iron ligands [ion binding]; other site 1435356004807 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1435356004808 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1435356004809 putative di-iron ligands [ion binding]; other site 1435356004810 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1435356004811 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1435356004812 FAD binding pocket [chemical binding]; other site 1435356004813 FAD binding motif [chemical binding]; other site 1435356004814 phosphate binding motif [ion binding]; other site 1435356004815 beta-alpha-beta structure motif; other site 1435356004816 NAD binding pocket [chemical binding]; other site 1435356004817 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1435356004818 catalytic loop [active] 1435356004819 iron binding site [ion binding]; other site 1435356004820 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1435356004821 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1435356004822 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 1435356004823 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1435356004824 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 1435356004825 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1435356004826 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1435356004827 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1435356004828 nucleotide binding region [chemical binding]; other site 1435356004829 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1435356004830 30S subunit binding site; other site 1435356004831 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1435356004832 lipoprotein LpqB; Provisional; Region: PRK13616 1435356004833 Sporulation and spore germination; Region: Germane; pfam10646 1435356004834 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1435356004835 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1435356004836 dimerization interface [polypeptide binding]; other site 1435356004837 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1435356004838 dimer interface [polypeptide binding]; other site 1435356004839 phosphorylation site [posttranslational modification] 1435356004840 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1435356004841 ATP binding site [chemical binding]; other site 1435356004842 Mg2+ binding site [ion binding]; other site 1435356004843 G-X-G motif; other site 1435356004844 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1435356004845 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1435356004846 active site 1435356004847 phosphorylation site [posttranslational modification] 1435356004848 intermolecular recognition site; other site 1435356004849 dimerization interface [polypeptide binding]; other site 1435356004850 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1435356004851 DNA binding site [nucleotide binding] 1435356004852 thymidylate kinase; Validated; Region: PRK07933 1435356004853 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1435356004854 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1435356004855 homotetramer interface [polypeptide binding]; other site 1435356004856 ligand binding site [chemical binding]; other site 1435356004857 catalytic site [active] 1435356004858 NAD binding site [chemical binding]; other site 1435356004859 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356004860 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356004861 Rubredoxin [Energy production and conversion]; Region: COG1773 1435356004862 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1435356004863 iron binding site [ion binding]; other site 1435356004864 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1435356004865 Rubredoxin; Region: Rubredoxin; pfam00301 1435356004866 iron binding site [ion binding]; other site 1435356004867 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 1435356004868 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1435356004869 Di-iron ligands [ion binding]; other site 1435356004870 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1435356004871 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1435356004872 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1435356004873 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1435356004874 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 1435356004875 active site 1435356004876 substrate binding site [chemical binding]; other site 1435356004877 metal binding site [ion binding]; metal-binding site 1435356004878 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 1435356004879 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 1435356004880 Transcription factor WhiB; Region: Whib; pfam02467 1435356004881 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 1435356004882 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 1435356004883 phosphate binding site [ion binding]; other site 1435356004884 dimer interface [polypeptide binding]; other site 1435356004885 substrate binding site [chemical binding]; other site 1435356004886 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 1435356004887 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 1435356004888 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 1435356004889 putative FMN binding site [chemical binding]; other site 1435356004890 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 1435356004891 nudix motif; other site 1435356004892 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 1435356004893 active site 1435356004894 catalytic triad [active] 1435356004895 oxyanion hole [active] 1435356004896 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1435356004897 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1435356004898 active site 1435356004899 Substrate binding site; other site 1435356004900 Mg++ binding site; other site 1435356004901 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1435356004902 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1435356004903 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1435356004904 Probable Catalytic site; other site 1435356004905 metal-binding site 1435356004906 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1435356004907 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1435356004908 NADP binding site [chemical binding]; other site 1435356004909 active site 1435356004910 putative substrate binding site [chemical binding]; other site 1435356004911 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1435356004912 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1435356004913 TIGR03089 family protein; Region: TIGR03089 1435356004914 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1435356004915 FtsX-like permease family; Region: FtsX; pfam02687 1435356004916 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1435356004917 FtsX-like permease family; Region: FtsX; pfam02687 1435356004918 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1435356004919 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1435356004920 Walker A/P-loop; other site 1435356004921 ATP binding site [chemical binding]; other site 1435356004922 Q-loop/lid; other site 1435356004923 ABC transporter signature motif; other site 1435356004924 Walker B; other site 1435356004925 D-loop; other site 1435356004926 H-loop/switch region; other site 1435356004927 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1435356004928 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1435356004929 active site 1435356004930 phosphorylation site [posttranslational modification] 1435356004931 intermolecular recognition site; other site 1435356004932 dimerization interface [polypeptide binding]; other site 1435356004933 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1435356004934 DNA binding residues [nucleotide binding] 1435356004935 dimerization interface [polypeptide binding]; other site 1435356004936 Histidine kinase; Region: HisKA_3; pfam07730 1435356004937 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1435356004938 Mg2+ binding site [ion binding]; other site 1435356004939 G-X-G motif; other site 1435356004940 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1435356004941 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1435356004942 ATP-grasp domain; Region: ATP-grasp; pfam02222 1435356004943 Predicted membrane protein [Function unknown]; Region: COG2246 1435356004944 GtrA-like protein; Region: GtrA; pfam04138 1435356004945 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1435356004946 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1435356004947 ATP binding site [chemical binding]; other site 1435356004948 Mg2+ binding site [ion binding]; other site 1435356004949 G-X-G motif; other site 1435356004950 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1435356004951 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1435356004952 active site 1435356004953 phosphorylation site [posttranslational modification] 1435356004954 intermolecular recognition site; other site 1435356004955 dimerization interface [polypeptide binding]; other site 1435356004956 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1435356004957 DNA binding site [nucleotide binding] 1435356004958 Bacterial PH domain; Region: DUF304; pfam03703 1435356004959 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1435356004960 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1435356004961 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1435356004962 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1435356004963 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1435356004964 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1435356004965 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 1435356004966 Maf-like protein; Region: Maf; pfam02545 1435356004967 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1435356004968 active site 1435356004969 dimer interface [polypeptide binding]; other site 1435356004970 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 1435356004971 heme-binding site [chemical binding]; other site 1435356004972 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1435356004973 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1435356004974 active site residue [active] 1435356004975 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1435356004976 active site residue [active] 1435356004977 Fe-S metabolism associated domain; Region: SufE; cl00951 1435356004978 peptide synthase; Provisional; Region: PRK12316 1435356004979 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1435356004980 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1435356004981 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1435356004982 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1435356004983 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1435356004984 carboxyltransferase (CT) interaction site; other site 1435356004985 biotinylation site [posttranslational modification]; other site 1435356004986 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1435356004987 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1435356004988 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1435356004989 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1435356004990 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1435356004991 L-lysine aminotransferase; Provisional; Region: PRK08297 1435356004992 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1435356004993 inhibitor-cofactor binding pocket; inhibition site 1435356004994 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1435356004995 catalytic residue [active] 1435356004996 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1435356004997 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1435356004998 putative DNA binding site [nucleotide binding]; other site 1435356004999 putative Zn2+ binding site [ion binding]; other site 1435356005000 AsnC family; Region: AsnC_trans_reg; pfam01037 1435356005001 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1435356005002 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 1435356005003 tetrameric interface [polypeptide binding]; other site 1435356005004 NAD binding site [chemical binding]; other site 1435356005005 catalytic residues [active] 1435356005006 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 1435356005007 FAD binding domain; Region: FAD_binding_4; pfam01565 1435356005008 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1435356005009 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1435356005010 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 1435356005011 ATP binding site [chemical binding]; other site 1435356005012 putative Mg++ binding site [ion binding]; other site 1435356005013 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1435356005014 nucleotide binding region [chemical binding]; other site 1435356005015 ATP-binding site [chemical binding]; other site 1435356005016 DEAD/H associated; Region: DEAD_assoc; pfam08494 1435356005017 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1435356005018 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 1435356005019 putative DNA binding site [nucleotide binding]; other site 1435356005020 catalytic residue [active] 1435356005021 putative H2TH interface [polypeptide binding]; other site 1435356005022 putative catalytic residues [active] 1435356005023 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1435356005024 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1435356005025 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1435356005026 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1435356005027 glycerol kinase; Provisional; Region: glpK; PRK00047 1435356005028 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 1435356005029 N- and C-terminal domain interface [polypeptide binding]; other site 1435356005030 active site 1435356005031 MgATP binding site [chemical binding]; other site 1435356005032 catalytic site [active] 1435356005033 metal binding site [ion binding]; metal-binding site 1435356005034 putative homotetramer interface [polypeptide binding]; other site 1435356005035 glycerol binding site [chemical binding]; other site 1435356005036 homodimer interface [polypeptide binding]; other site 1435356005037 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 1435356005038 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1435356005039 NAD binding site [chemical binding]; other site 1435356005040 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1435356005041 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1435356005042 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1435356005043 putative active site pocket [active] 1435356005044 dimerization interface [polypeptide binding]; other site 1435356005045 putative catalytic residue [active] 1435356005046 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1435356005047 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1435356005048 Walker A/P-loop; other site 1435356005049 ATP binding site [chemical binding]; other site 1435356005050 Q-loop/lid; other site 1435356005051 ABC transporter signature motif; other site 1435356005052 Walker B; other site 1435356005053 D-loop; other site 1435356005054 H-loop/switch region; other site 1435356005055 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1435356005056 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1435356005057 dimer interface [polypeptide binding]; other site 1435356005058 conserved gate region; other site 1435356005059 putative PBP binding loops; other site 1435356005060 ABC-ATPase subunit interface; other site 1435356005061 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1435356005062 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1435356005063 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1435356005064 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1435356005065 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 1435356005066 metal binding site [ion binding]; metal-binding site 1435356005067 putative dimer interface [polypeptide binding]; other site 1435356005068 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 1435356005069 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1435356005070 metal binding site [ion binding]; metal-binding site 1435356005071 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1435356005072 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1435356005073 substrate binding site [chemical binding]; other site 1435356005074 oxyanion hole (OAH) forming residues; other site 1435356005075 trimer interface [polypeptide binding]; other site 1435356005076 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1435356005077 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1435356005078 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1435356005079 active site 1435356005080 substrate binding site [chemical binding]; other site 1435356005081 metal binding site [ion binding]; metal-binding site 1435356005082 MspA; Region: MspA; pfam09203 1435356005083 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1435356005084 active site 1435356005085 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1435356005086 NlpC/P60 family; Region: NLPC_P60; pfam00877 1435356005087 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 1435356005088 adenosine deaminase; Provisional; Region: PRK09358 1435356005089 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1435356005090 active site 1435356005091 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1435356005092 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1435356005093 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1435356005094 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 1435356005095 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1435356005096 active site 1435356005097 catalytic motif [active] 1435356005098 Zn binding site [ion binding]; other site 1435356005099 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 1435356005100 putative Iron-sulfur protein interface [polypeptide binding]; other site 1435356005101 putative proximal heme binding site [chemical binding]; other site 1435356005102 putative SdhD-like interface [polypeptide binding]; other site 1435356005103 putative distal heme binding site [chemical binding]; other site 1435356005104 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 1435356005105 putative Iron-sulfur protein interface [polypeptide binding]; other site 1435356005106 putative proximal heme binding site [chemical binding]; other site 1435356005107 putative SdhC-like subunit interface [polypeptide binding]; other site 1435356005108 putative distal heme binding site [chemical binding]; other site 1435356005109 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 1435356005110 L-aspartate oxidase; Provisional; Region: PRK06175 1435356005111 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1435356005112 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1435356005113 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1435356005114 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1435356005115 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1435356005116 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1435356005117 active site 1435356005118 HIGH motif; other site 1435356005119 dimer interface [polypeptide binding]; other site 1435356005120 KMSKS motif; other site 1435356005121 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 1435356005122 putative active site [active] 1435356005123 putative catalytic site [active] 1435356005124 putative DNA binding site [nucleotide binding]; other site 1435356005125 putative phosphate binding site [ion binding]; other site 1435356005126 metal binding site A [ion binding]; metal-binding site 1435356005127 putative AP binding site [nucleotide binding]; other site 1435356005128 putative metal binding site B [ion binding]; other site 1435356005129 isocitrate dehydrogenase; Validated; Region: PRK08299 1435356005130 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1435356005131 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 1435356005132 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 1435356005133 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 1435356005134 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1435356005135 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1435356005136 homodimer interface [polypeptide binding]; other site 1435356005137 NADP binding site [chemical binding]; other site 1435356005138 substrate binding site [chemical binding]; other site 1435356005139 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1435356005140 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1435356005141 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1435356005142 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1435356005143 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1435356005144 active site 1435356005145 TDP-binding site; other site 1435356005146 acceptor substrate-binding pocket; other site 1435356005147 TIGR03086 family protein; Region: TIGR03086 1435356005148 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1435356005149 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1435356005150 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1435356005151 active site residue [active] 1435356005152 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 1435356005153 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1435356005154 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1435356005155 active site 1435356005156 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1435356005157 generic binding surface II; other site 1435356005158 generic binding surface I; other site 1435356005159 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1435356005160 hydrophobic ligand binding site; other site 1435356005161 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1435356005162 dimerization interface [polypeptide binding]; other site 1435356005163 putative DNA binding site [nucleotide binding]; other site 1435356005164 putative Zn2+ binding site [ion binding]; other site 1435356005165 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159 1435356005166 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1435356005167 putative ligand binding site [chemical binding]; other site 1435356005168 putative NAD binding site [chemical binding]; other site 1435356005169 catalytic site [active] 1435356005170 YCII-related domain; Region: YCII; cl00999 1435356005171 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1435356005172 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1435356005173 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1435356005174 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1435356005175 MMPL family; Region: MMPL; pfam03176 1435356005176 MMPL family; Region: MMPL; pfam03176 1435356005177 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 1435356005178 putative dimer interface [polypeptide binding]; other site 1435356005179 putative [2Fe-2S] cluster binding site [ion binding]; other site 1435356005180 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1435356005181 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1435356005182 NAD(P) binding site [chemical binding]; other site 1435356005183 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1435356005184 putative catalytic site [active] 1435356005185 putative metal binding site [ion binding]; other site 1435356005186 putative phosphate binding site [ion binding]; other site 1435356005187 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1435356005188 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1435356005189 DNA Polymerase Y-family; Region: PolY_like; cd03468 1435356005190 DNA binding site [nucleotide binding] 1435356005191 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1435356005192 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1435356005193 active site 1435356005194 ATP binding site [chemical binding]; other site 1435356005195 substrate binding site [chemical binding]; other site 1435356005196 activation loop (A-loop); other site 1435356005197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1435356005198 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1435356005199 active site 1435356005200 phosphorylation site [posttranslational modification] 1435356005201 intermolecular recognition site; other site 1435356005202 dimerization interface [polypeptide binding]; other site 1435356005203 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1435356005204 DNA binding residues [nucleotide binding] 1435356005205 dimerization interface [polypeptide binding]; other site 1435356005206 PspC domain; Region: PspC; pfam04024 1435356005207 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1435356005208 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1435356005209 ATP binding site [chemical binding]; other site 1435356005210 Mg2+ binding site [ion binding]; other site 1435356005211 G-X-G motif; other site 1435356005212 PspC domain; Region: PspC; pfam04024 1435356005213 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1435356005214 GMP synthase; Reviewed; Region: guaA; PRK00074 1435356005215 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1435356005216 AMP/PPi binding site [chemical binding]; other site 1435356005217 candidate oxyanion hole; other site 1435356005218 catalytic triad [active] 1435356005219 potential glutamine specificity residues [chemical binding]; other site 1435356005220 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1435356005221 ATP Binding subdomain [chemical binding]; other site 1435356005222 Ligand Binding sites [chemical binding]; other site 1435356005223 Dimerization subdomain; other site 1435356005224 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1435356005225 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1435356005226 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1435356005227 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1435356005228 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1435356005229 phosphate binding site [ion binding]; other site 1435356005230 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1435356005231 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1435356005232 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1435356005233 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1435356005234 active site 1435356005235 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 1435356005236 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1435356005237 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1435356005238 DNA binding residues [nucleotide binding] 1435356005239 Transcription factor WhiB; Region: Whib; pfam02467 1435356005240 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1435356005241 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1435356005242 ring oligomerisation interface [polypeptide binding]; other site 1435356005243 ATP/Mg binding site [chemical binding]; other site 1435356005244 stacking interactions; other site 1435356005245 hinge regions; other site 1435356005246 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1435356005247 oligomerisation interface [polypeptide binding]; other site 1435356005248 mobile loop; other site 1435356005249 roof hairpin; other site 1435356005250 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1435356005251 UGMP family protein; Validated; Region: PRK09604 1435356005252 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1435356005253 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1435356005254 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1435356005255 Glycoprotease family; Region: Peptidase_M22; pfam00814 1435356005256 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1435356005257 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1435356005258 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1435356005259 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1435356005260 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1435356005261 alanine racemase; Reviewed; Region: alr; PRK00053 1435356005262 active site 1435356005263 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1435356005264 dimer interface [polypeptide binding]; other site 1435356005265 substrate binding site [chemical binding]; other site 1435356005266 catalytic residues [active] 1435356005267 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1435356005268 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1435356005269 putative substrate binding site [chemical binding]; other site 1435356005270 putative ATP binding site [chemical binding]; other site 1435356005271 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1435356005272 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1435356005273 glutaminase active site [active] 1435356005274 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1435356005275 dimer interface [polypeptide binding]; other site 1435356005276 active site 1435356005277 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1435356005278 dimer interface [polypeptide binding]; other site 1435356005279 active site 1435356005280 Chlorophyllase enzyme; Region: Chlorophyllase2; pfam12740 1435356005281 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 1435356005282 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 1435356005283 active site 1435356005284 substrate binding site [chemical binding]; other site 1435356005285 metal binding site [ion binding]; metal-binding site 1435356005286 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1435356005287 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1435356005288 23S rRNA interface [nucleotide binding]; other site 1435356005289 L3 interface [polypeptide binding]; other site 1435356005290 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1435356005291 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1435356005292 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 1435356005293 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1435356005294 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1435356005295 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1435356005296 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1435356005297 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1435356005298 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 1435356005299 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1435356005300 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1435356005301 active site 1435356005302 catalytic residues [active] 1435356005303 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919 1435356005304 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1435356005305 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1435356005306 Predicted flavoprotein [General function prediction only]; Region: COG0431 1435356005307 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356005308 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356005309 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1435356005310 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1435356005311 active site 1435356005312 Phosphotransferase enzyme family; Region: APH; pfam01636 1435356005313 active site 1435356005314 ATP binding site [chemical binding]; other site 1435356005315 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1435356005316 Putative esterase; Region: Esterase; pfam00756 1435356005317 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1435356005318 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1435356005319 dimerization interface 3.5A [polypeptide binding]; other site 1435356005320 active site 1435356005321 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1435356005322 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1435356005323 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1435356005324 alphaNTD - beta interaction site [polypeptide binding]; other site 1435356005325 alphaNTD homodimer interface [polypeptide binding]; other site 1435356005326 alphaNTD - beta' interaction site [polypeptide binding]; other site 1435356005327 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1435356005328 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1435356005329 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1435356005330 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1435356005331 RNA binding surface [nucleotide binding]; other site 1435356005332 30S ribosomal protein S11; Validated; Region: PRK05309 1435356005333 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1435356005334 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1435356005335 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1435356005336 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1435356005337 rRNA binding site [nucleotide binding]; other site 1435356005338 predicted 30S ribosome binding site; other site 1435356005339 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1435356005340 putative active site [active] 1435356005341 dimerization interface [polypeptide binding]; other site 1435356005342 putative tRNAtyr binding site [nucleotide binding]; other site 1435356005343 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1435356005344 active site 1435356005345 adenylate kinase; Reviewed; Region: adk; PRK00279 1435356005346 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1435356005347 AMP-binding site [chemical binding]; other site 1435356005348 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1435356005349 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1435356005350 SecY translocase; Region: SecY; pfam00344 1435356005351 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1435356005352 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1435356005353 23S rRNA binding site [nucleotide binding]; other site 1435356005354 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1435356005355 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1435356005356 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1435356005357 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1435356005358 5S rRNA interface [nucleotide binding]; other site 1435356005359 L27 interface [polypeptide binding]; other site 1435356005360 23S rRNA interface [nucleotide binding]; other site 1435356005361 L5 interface [polypeptide binding]; other site 1435356005362 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1435356005363 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1435356005364 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1435356005365 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1435356005366 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1435356005367 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1435356005368 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1435356005369 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1435356005370 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1435356005371 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1435356005372 RNA binding site [nucleotide binding]; other site 1435356005373 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1435356005374 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1435356005375 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1435356005376 23S rRNA interface [nucleotide binding]; other site 1435356005377 putative translocon interaction site; other site 1435356005378 signal recognition particle (SRP54) interaction site; other site 1435356005379 L23 interface [polypeptide binding]; other site 1435356005380 trigger factor interaction site; other site 1435356005381 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1435356005382 23S rRNA interface [nucleotide binding]; other site 1435356005383 5S rRNA interface [nucleotide binding]; other site 1435356005384 putative antibiotic binding site [chemical binding]; other site 1435356005385 L25 interface [polypeptide binding]; other site 1435356005386 L27 interface [polypeptide binding]; other site 1435356005387 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 1435356005388 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1435356005389 G-X-X-G motif; other site 1435356005390 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1435356005391 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1435356005392 putative translocon binding site; other site 1435356005393 protein-rRNA interface [nucleotide binding]; other site 1435356005394 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1435356005395 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1435356005396 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1435356005397 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1435356005398 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1435356005399 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1435356005400 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1435356005401 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1435356005402 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1435356005403 Amidase; Region: Amidase; cl11426 1435356005404 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1435356005405 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1435356005406 DNA-binding site [nucleotide binding]; DNA binding site 1435356005407 FCD domain; Region: FCD; pfam07729 1435356005408 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1435356005409 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1435356005410 Walker A/P-loop; other site 1435356005411 ATP binding site [chemical binding]; other site 1435356005412 Q-loop/lid; other site 1435356005413 ABC transporter signature motif; other site 1435356005414 Walker B; other site 1435356005415 D-loop; other site 1435356005416 H-loop/switch region; other site 1435356005417 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1435356005418 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1435356005419 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1435356005420 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1435356005421 Helix-turn-helix domain; Region: HTH_38; pfam13936 1435356005422 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1435356005423 Integrase core domain; Region: rve; pfam00665 1435356005424 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1435356005425 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1435356005426 Walker A motif; other site 1435356005427 ATP binding site [chemical binding]; other site 1435356005428 Walker B motif; other site 1435356005429 Homeodomain-like domain; Region: HTH_23; cl17451 1435356005430 Putative esterase; Region: Esterase; pfam00756 1435356005431 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1435356005432 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1435356005433 acyl-activating enzyme (AAE) consensus motif; other site 1435356005434 AMP binding site [chemical binding]; other site 1435356005435 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1435356005436 Condensation domain; Region: Condensation; pfam00668 1435356005437 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1435356005438 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1435356005439 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1435356005440 acyl-activating enzyme (AAE) consensus motif; other site 1435356005441 AMP binding site [chemical binding]; other site 1435356005442 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1435356005443 Condensation domain; Region: Condensation; pfam00668 1435356005444 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1435356005445 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1435356005446 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1435356005447 acyl-activating enzyme (AAE) consensus motif; other site 1435356005448 AMP binding site [chemical binding]; other site 1435356005449 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1435356005450 Condensation domain; Region: Condensation; pfam00668 1435356005451 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1435356005452 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1435356005453 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1435356005454 acyl-activating enzyme (AAE) consensus motif; other site 1435356005455 AMP binding site [chemical binding]; other site 1435356005456 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1435356005457 Condensation domain; Region: Condensation; pfam00668 1435356005458 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1435356005459 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1435356005460 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1435356005461 acyl-activating enzyme (AAE) consensus motif; other site 1435356005462 AMP binding site [chemical binding]; other site 1435356005463 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1435356005464 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1435356005465 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1435356005466 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1435356005467 acyl-activating enzyme (AAE) consensus motif; other site 1435356005468 AMP binding site [chemical binding]; other site 1435356005469 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1435356005470 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1435356005471 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1435356005472 acyl-activating enzyme (AAE) consensus motif; other site 1435356005473 AMP binding site [chemical binding]; other site 1435356005474 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1435356005475 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1435356005476 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1435356005477 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1435356005478 acyl-activating enzyme (AAE) consensus motif; other site 1435356005479 AMP binding site [chemical binding]; other site 1435356005480 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1435356005481 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1435356005482 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1435356005483 acyl-activating enzyme (AAE) consensus motif; other site 1435356005484 AMP binding site [chemical binding]; other site 1435356005485 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1435356005486 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1435356005487 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1435356005488 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1435356005489 acyl-activating enzyme (AAE) consensus motif; other site 1435356005490 AMP binding site [chemical binding]; other site 1435356005491 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1435356005492 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1435356005493 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1435356005494 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1435356005495 acyl-activating enzyme (AAE) consensus motif; other site 1435356005496 AMP binding site [chemical binding]; other site 1435356005497 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1435356005498 Condensation domain; Region: Condensation; pfam00668 1435356005499 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1435356005500 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1435356005501 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1435356005502 acyl-activating enzyme (AAE) consensus motif; other site 1435356005503 AMP binding site [chemical binding]; other site 1435356005504 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1435356005505 Condensation domain; Region: Condensation; pfam00668 1435356005506 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1435356005507 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1435356005508 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1435356005509 acyl-activating enzyme (AAE) consensus motif; other site 1435356005510 Condensation domain; Region: Condensation; pfam00668 1435356005511 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1435356005512 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1435356005513 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1435356005514 acyl-activating enzyme (AAE) consensus motif; other site 1435356005515 AMP binding site [chemical binding]; other site 1435356005516 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1435356005517 Condensation domain; Region: Condensation; pfam00668 1435356005518 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1435356005519 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1435356005520 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1435356005521 acyl-activating enzyme (AAE) consensus motif; other site 1435356005522 AMP binding site [chemical binding]; other site 1435356005523 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1435356005524 Condensation domain; Region: Condensation; pfam00668 1435356005525 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1435356005526 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1435356005527 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1435356005528 acyl-activating enzyme (AAE) consensus motif; other site 1435356005529 AMP binding site [chemical binding]; other site 1435356005530 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1435356005531 peptide synthase; Provisional; Region: PRK12467 1435356005532 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1435356005533 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1435356005534 acyl-activating enzyme (AAE) consensus motif; other site 1435356005535 AMP binding site [chemical binding]; other site 1435356005536 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1435356005537 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1435356005538 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1435356005539 acyl-activating enzyme (AAE) consensus motif; other site 1435356005540 AMP binding site [chemical binding]; other site 1435356005541 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1435356005542 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1435356005543 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1435356005544 acyl-activating enzyme (AAE) consensus motif; other site 1435356005545 AMP binding site [chemical binding]; other site 1435356005546 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1435356005547 Condensation domain; Region: Condensation; pfam00668 1435356005548 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1435356005549 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1435356005550 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1435356005551 acyl-activating enzyme (AAE) consensus motif; other site 1435356005552 AMP binding site [chemical binding]; other site 1435356005553 Condensation domain; Region: Condensation; pfam00668 1435356005554 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1435356005555 Condensation domain; Region: Condensation; pfam00668 1435356005556 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1435356005557 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1435356005558 Condensation domain; Region: Condensation; pfam00668 1435356005559 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1435356005560 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1435356005561 acyl-activating enzyme (AAE) consensus motif; other site 1435356005562 AMP binding site [chemical binding]; other site 1435356005563 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1435356005564 Condensation domain; Region: Condensation; pfam00668 1435356005565 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1435356005566 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1435356005567 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1435356005568 acyl-activating enzyme (AAE) consensus motif; other site 1435356005569 AMP binding site [chemical binding]; other site 1435356005570 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1435356005571 Condensation domain; Region: Condensation; pfam00668 1435356005572 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1435356005573 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1435356005574 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1435356005575 acyl-activating enzyme (AAE) consensus motif; other site 1435356005576 AMP binding site [chemical binding]; other site 1435356005577 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1435356005578 Condensation domain; Region: Condensation; pfam00668 1435356005579 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1435356005580 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1435356005581 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1435356005582 acyl-activating enzyme (AAE) consensus motif; other site 1435356005583 AMP binding site [chemical binding]; other site 1435356005584 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1435356005585 Condensation domain; Region: Condensation; pfam00668 1435356005586 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1435356005587 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1435356005588 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1435356005589 acyl-activating enzyme (AAE) consensus motif; other site 1435356005590 AMP binding site [chemical binding]; other site 1435356005591 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1435356005592 Condensation domain; Region: Condensation; pfam00668 1435356005593 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1435356005594 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1435356005595 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1435356005596 acyl-activating enzyme (AAE) consensus motif; other site 1435356005597 AMP binding site [chemical binding]; other site 1435356005598 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1435356005599 Condensation domain; Region: Condensation; pfam00668 1435356005600 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1435356005601 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1435356005602 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 1435356005603 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1435356005604 acyl-activating enzyme (AAE) consensus motif; other site 1435356005605 AMP binding site [chemical binding]; other site 1435356005606 active site 1435356005607 CoA binding site [chemical binding]; other site 1435356005608 AMP-binding domain protein; Validated; Region: PRK08315 1435356005609 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1435356005610 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1435356005611 acyl-activating enzyme (AAE) consensus motif; other site 1435356005612 putative AMP binding site [chemical binding]; other site 1435356005613 putative active site [active] 1435356005614 putative CoA binding site [chemical binding]; other site 1435356005615 metabolite-proton symporter; Region: 2A0106; TIGR00883 1435356005616 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356005617 putative substrate translocation pore; other site 1435356005618 Protein of unknown function (DUF779); Region: DUF779; cl01432 1435356005619 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 1435356005620 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1435356005621 NAD(P) binding site [chemical binding]; other site 1435356005622 catalytic residues [active] 1435356005623 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1435356005624 DNA binding site [nucleotide binding] 1435356005625 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 1435356005626 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1435356005627 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 1435356005628 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1435356005629 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 1435356005630 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1435356005631 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1435356005632 Coenzyme A binding pocket [chemical binding]; other site 1435356005633 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 1435356005634 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1435356005635 phosphate binding site [ion binding]; other site 1435356005636 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1435356005637 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1435356005638 classical (c) SDRs; Region: SDR_c; cd05233 1435356005639 NAD(P) binding site [chemical binding]; other site 1435356005640 active site 1435356005641 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 1435356005642 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1435356005643 phosphate binding site [ion binding]; other site 1435356005644 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 1435356005645 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1435356005646 FeS/SAM binding site; other site 1435356005647 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1435356005648 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 1435356005649 mycofactocin precursor; Region: mycofactocin; TIGR03969 1435356005650 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1435356005651 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356005652 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1435356005653 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1435356005654 S-adenosylmethionine binding site [chemical binding]; other site 1435356005655 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1435356005656 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1435356005657 active site 1435356005658 phosphorylation site [posttranslational modification] 1435356005659 intermolecular recognition site; other site 1435356005660 dimerization interface [polypeptide binding]; other site 1435356005661 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1435356005662 DNA binding residues [nucleotide binding] 1435356005663 dimerization interface [polypeptide binding]; other site 1435356005664 GAF domain; Region: GAF_3; pfam13492 1435356005665 GAF domain; Region: GAF_2; pfam13185 1435356005666 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1435356005667 Histidine kinase; Region: HisKA_3; pfam07730 1435356005668 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1435356005669 ATP binding site [chemical binding]; other site 1435356005670 Mg2+ binding site [ion binding]; other site 1435356005671 G-X-G motif; other site 1435356005672 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH4; cd08188 1435356005673 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1435356005674 putative active site [active] 1435356005675 metal binding site [ion binding]; metal-binding site 1435356005676 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1435356005677 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1435356005678 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 1435356005679 MoxR-like ATPases [General function prediction only]; Region: COG0714 1435356005680 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1435356005681 Walker A motif; other site 1435356005682 ATP binding site [chemical binding]; other site 1435356005683 NDMA-dependent methanol dehydrogenase; Region: NDMA_methanol; TIGR04266 1435356005684 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1435356005685 dimer interface [polypeptide binding]; other site 1435356005686 active site 1435356005687 metal binding site [ion binding]; metal-binding site 1435356005688 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1435356005689 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1435356005690 FAD binding pocket [chemical binding]; other site 1435356005691 FAD binding motif [chemical binding]; other site 1435356005692 phosphate binding motif [ion binding]; other site 1435356005693 beta-alpha-beta structure motif; other site 1435356005694 NAD(p) ribose binding residues [chemical binding]; other site 1435356005695 NAD binding pocket [chemical binding]; other site 1435356005696 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1435356005697 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1435356005698 catalytic loop [active] 1435356005699 iron binding site [ion binding]; other site 1435356005700 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356005701 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1435356005702 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1435356005703 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1435356005704 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1435356005705 Asp23 family; Region: Asp23; pfam03780 1435356005706 Asp23 family; Region: Asp23; pfam03780 1435356005707 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 1435356005708 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356005709 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356005710 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1435356005711 Beta-lactamase; Region: Beta-lactamase; pfam00144 1435356005712 elongation factor Tu; Reviewed; Region: PRK00049 1435356005713 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1435356005714 G1 box; other site 1435356005715 GEF interaction site [polypeptide binding]; other site 1435356005716 GTP/Mg2+ binding site [chemical binding]; other site 1435356005717 Switch I region; other site 1435356005718 G2 box; other site 1435356005719 G3 box; other site 1435356005720 Switch II region; other site 1435356005721 G4 box; other site 1435356005722 G5 box; other site 1435356005723 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1435356005724 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1435356005725 Antibiotic Binding Site [chemical binding]; other site 1435356005726 elongation factor G; Reviewed; Region: PRK00007 1435356005727 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1435356005728 G1 box; other site 1435356005729 putative GEF interaction site [polypeptide binding]; other site 1435356005730 GTP/Mg2+ binding site [chemical binding]; other site 1435356005731 Switch I region; other site 1435356005732 G2 box; other site 1435356005733 G3 box; other site 1435356005734 Switch II region; other site 1435356005735 G4 box; other site 1435356005736 G5 box; other site 1435356005737 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1435356005738 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1435356005739 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1435356005740 30S ribosomal protein S7; Validated; Region: PRK05302 1435356005741 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1435356005742 S17 interaction site [polypeptide binding]; other site 1435356005743 S8 interaction site; other site 1435356005744 16S rRNA interaction site [nucleotide binding]; other site 1435356005745 streptomycin interaction site [chemical binding]; other site 1435356005746 23S rRNA interaction site [nucleotide binding]; other site 1435356005747 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1435356005748 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1435356005749 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1435356005750 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356005751 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356005752 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356005753 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 1435356005754 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1435356005755 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1435356005756 active site 1435356005757 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1435356005758 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1435356005759 active site 1435356005760 TIGR03084 family protein; Region: TIGR03084 1435356005761 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1435356005762 Wyosine base formation; Region: Wyosine_form; pfam08608 1435356005763 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 1435356005764 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1435356005765 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1435356005766 putative dimerization interface [polypeptide binding]; other site 1435356005767 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 1435356005768 Domain of unknown function (DUF202); Region: DUF202; pfam02656 1435356005769 Predicted membrane protein [Function unknown]; Region: COG2149 1435356005770 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1435356005771 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1435356005772 iron-sulfur cluster [ion binding]; other site 1435356005773 [2Fe-2S] cluster binding site [ion binding]; other site 1435356005774 Ferredoxin [Energy production and conversion]; Region: COG1146 1435356005775 4Fe-4S binding domain; Region: Fer4; pfam00037 1435356005776 ferredoxin-NADP+ reductase; Region: PLN02852 1435356005777 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1435356005778 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 1435356005779 active site 2 [active] 1435356005780 active site 1 [active] 1435356005781 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1435356005782 catalytic core [active] 1435356005783 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1435356005784 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1435356005785 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1435356005786 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1435356005787 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1435356005788 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1435356005789 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1435356005790 G-loop; other site 1435356005791 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1435356005792 DNA binding site [nucleotide binding] 1435356005793 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1435356005794 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1435356005795 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1435356005796 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1435356005797 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1435356005798 RPB1 interaction site [polypeptide binding]; other site 1435356005799 RPB10 interaction site [polypeptide binding]; other site 1435356005800 RPB11 interaction site [polypeptide binding]; other site 1435356005801 RPB3 interaction site [polypeptide binding]; other site 1435356005802 RPB12 interaction site [polypeptide binding]; other site 1435356005803 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1435356005804 mce related protein; Region: MCE; pfam02470 1435356005805 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1435356005806 mce related protein; Region: MCE; pfam02470 1435356005807 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1435356005808 mce related protein; Region: MCE; pfam02470 1435356005809 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1435356005810 mce related protein; Region: MCE; pfam02470 1435356005811 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 1435356005812 mce related protein; Region: MCE; pfam02470 1435356005813 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1435356005814 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1435356005815 mce related protein; Region: MCE; pfam02470 1435356005816 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1435356005817 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1435356005818 Permease; Region: Permease; pfam02405 1435356005819 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1435356005820 Permease; Region: Permease; pfam02405 1435356005821 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1435356005822 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1435356005823 Walker A/P-loop; other site 1435356005824 ATP binding site [chemical binding]; other site 1435356005825 Q-loop/lid; other site 1435356005826 ABC transporter signature motif; other site 1435356005827 Walker B; other site 1435356005828 D-loop; other site 1435356005829 H-loop/switch region; other site 1435356005830 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1435356005831 core dimer interface [polypeptide binding]; other site 1435356005832 peripheral dimer interface [polypeptide binding]; other site 1435356005833 L10 interface [polypeptide binding]; other site 1435356005834 L11 interface [polypeptide binding]; other site 1435356005835 putative EF-Tu interaction site [polypeptide binding]; other site 1435356005836 putative EF-G interaction site [polypeptide binding]; other site 1435356005837 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1435356005838 23S rRNA interface [nucleotide binding]; other site 1435356005839 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1435356005840 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1435356005841 mRNA/rRNA interface [nucleotide binding]; other site 1435356005842 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1435356005843 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1435356005844 23S rRNA interface [nucleotide binding]; other site 1435356005845 L7/L12 interface [polypeptide binding]; other site 1435356005846 putative thiostrepton binding site; other site 1435356005847 L25 interface [polypeptide binding]; other site 1435356005848 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1435356005849 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1435356005850 putative homodimer interface [polypeptide binding]; other site 1435356005851 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1435356005852 heterodimer interface [polypeptide binding]; other site 1435356005853 homodimer interface [polypeptide binding]; other site 1435356005854 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1435356005855 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1435356005856 active site 2 [active] 1435356005857 active site 1 [active] 1435356005858 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1435356005859 active site 1435356005860 catalytic site [active] 1435356005861 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1435356005862 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1435356005863 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1435356005864 heat shock protein HtpX; Provisional; Region: PRK03072 1435356005865 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1435356005866 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1435356005867 substrate binding pocket [chemical binding]; other site 1435356005868 chain length determination region; other site 1435356005869 substrate-Mg2+ binding site; other site 1435356005870 catalytic residues [active] 1435356005871 aspartate-rich region 1; other site 1435356005872 active site lid residues [active] 1435356005873 aspartate-rich region 2; other site 1435356005874 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1435356005875 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1435356005876 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1435356005877 S-adenosylmethionine binding site [chemical binding]; other site 1435356005878 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1435356005879 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1435356005880 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1435356005881 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1435356005882 dimer interface [polypeptide binding]; other site 1435356005883 tetramer interface [polypeptide binding]; other site 1435356005884 PYR/PP interface [polypeptide binding]; other site 1435356005885 TPP binding site [chemical binding]; other site 1435356005886 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1435356005887 TPP-binding site; other site 1435356005888 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1435356005889 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1435356005890 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1435356005891 FAD binding pocket [chemical binding]; other site 1435356005892 FAD binding motif [chemical binding]; other site 1435356005893 phosphate binding motif [ion binding]; other site 1435356005894 NAD binding pocket [chemical binding]; other site 1435356005895 O-succinylbenzoate synthase; Provisional; Region: PRK02901 1435356005896 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1435356005897 active site 1435356005898 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1435356005899 CoenzymeA binding site [chemical binding]; other site 1435356005900 subunit interaction site [polypeptide binding]; other site 1435356005901 PHB binding site; other site 1435356005902 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1435356005903 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1435356005904 substrate binding site [chemical binding]; other site 1435356005905 oxyanion hole (OAH) forming residues; other site 1435356005906 trimer interface [polypeptide binding]; other site 1435356005907 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1435356005908 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1435356005909 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1435356005910 active site 1435356005911 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1435356005912 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1435356005913 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 1435356005914 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1435356005915 acyl-activating enzyme (AAE) consensus motif; other site 1435356005916 AMP binding site [chemical binding]; other site 1435356005917 active site 1435356005918 CoA binding site [chemical binding]; other site 1435356005919 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1435356005920 UbiA prenyltransferase family; Region: UbiA; pfam01040 1435356005921 Membrane protein of unknown function; Region: DUF360; pfam04020 1435356005922 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 1435356005923 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1435356005924 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1435356005925 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1435356005926 catalytic residue [active] 1435356005927 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 1435356005928 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1435356005929 DNA binding residues [nucleotide binding] 1435356005930 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1435356005931 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1435356005932 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 1435356005933 ResB-like family; Region: ResB; pfam05140 1435356005934 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1435356005935 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1435356005936 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1435356005937 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1435356005938 catalytic residues [active] 1435356005939 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1435356005940 catalytic core [active] 1435356005941 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1435356005942 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1435356005943 inhibitor-cofactor binding pocket; inhibition site 1435356005944 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1435356005945 catalytic residue [active] 1435356005946 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1435356005947 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1435356005948 active site 1435356005949 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1435356005950 dimer interface [polypeptide binding]; other site 1435356005951 active site 1435356005952 Schiff base residues; other site 1435356005953 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 1435356005954 homodimer interface [polypeptide binding]; other site 1435356005955 active site 1435356005956 SAM binding site [chemical binding]; other site 1435356005957 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1435356005958 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1435356005959 active site 1435356005960 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1435356005961 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 1435356005962 domain interfaces; other site 1435356005963 active site 1435356005964 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1435356005965 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1435356005966 tRNA; other site 1435356005967 putative tRNA binding site [nucleotide binding]; other site 1435356005968 putative NADP binding site [chemical binding]; other site 1435356005969 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1435356005970 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1435356005971 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1435356005972 CoA binding domain; Region: CoA_binding; pfam02629 1435356005973 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1435356005974 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1435356005975 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1435356005976 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1435356005977 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1435356005978 putative acyl-acceptor binding pocket; other site 1435356005979 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 1435356005980 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1435356005981 putative NAD(P) binding site [chemical binding]; other site 1435356005982 active site 1435356005983 putative substrate binding site [chemical binding]; other site 1435356005984 DNA binding domain, excisionase family; Region: excise; TIGR01764 1435356005985 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1435356005986 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1435356005987 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1435356005988 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1435356005989 CoenzymeA binding site [chemical binding]; other site 1435356005990 subunit interaction site [polypeptide binding]; other site 1435356005991 PHB binding site; other site 1435356005992 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1435356005993 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1435356005994 DNA binding residues [nucleotide binding] 1435356005995 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1435356005996 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1435356005997 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1435356005998 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1435356005999 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1435356006000 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1435356006001 active site 1435356006002 phosphorylation site [posttranslational modification] 1435356006003 intermolecular recognition site; other site 1435356006004 dimerization interface [polypeptide binding]; other site 1435356006005 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1435356006006 DNA binding site [nucleotide binding] 1435356006007 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1435356006008 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1435356006009 dimer interface [polypeptide binding]; other site 1435356006010 phosphorylation site [posttranslational modification] 1435356006011 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1435356006012 ATP binding site [chemical binding]; other site 1435356006013 Mg2+ binding site [ion binding]; other site 1435356006014 G-X-G motif; other site 1435356006015 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1435356006016 catalytic core [active] 1435356006017 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1435356006018 Uncharacterized conserved protein [Function unknown]; Region: COG3349 1435356006019 4-coumarate--CoA ligase; Region: PLN02246 1435356006020 4-Coumarate-CoA Ligase (4CL); Region: 4CL; cd05904 1435356006021 acyl-activating enzyme (AAE) consensus motif; other site 1435356006022 active site 1435356006023 putative CoA binding site [chemical binding]; other site 1435356006024 AMP binding site [chemical binding]; other site 1435356006025 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1435356006026 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1435356006027 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1435356006028 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1435356006029 putative ADP-binding pocket [chemical binding]; other site 1435356006030 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1435356006031 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1435356006032 Tocopherol cyclase; Region: Tocopherol_cycl; cl14571 1435356006033 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1435356006034 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356006035 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356006036 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1435356006037 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1435356006038 NAD(P) binding site [chemical binding]; other site 1435356006039 active site 1435356006040 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 1435356006041 FAD binding domain; Region: FAD_binding_4; pfam01565 1435356006042 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1435356006043 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1435356006044 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1435356006045 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1435356006046 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1435356006047 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1435356006048 intersubunit interface [polypeptide binding]; other site 1435356006049 active site 1435356006050 catalytic residue [active] 1435356006051 Predicted acetyltransferase [General function prediction only]; Region: COG3153 1435356006052 Coenzyme A binding pocket [chemical binding]; other site 1435356006053 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1435356006054 S-adenosylmethionine binding site [chemical binding]; other site 1435356006055 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1435356006056 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1435356006057 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1435356006058 putative active site [active] 1435356006059 putative substrate binding site [chemical binding]; other site 1435356006060 putative cosubstrate binding site; other site 1435356006061 catalytic site [active] 1435356006062 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1435356006063 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1435356006064 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 1435356006065 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1435356006066 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1435356006067 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1435356006068 non-specific DNA binding site [nucleotide binding]; other site 1435356006069 salt bridge; other site 1435356006070 sequence-specific DNA binding site [nucleotide binding]; other site 1435356006071 Predicted membrane protein [Function unknown]; Region: COG2733 1435356006072 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356006073 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356006074 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 1435356006075 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1435356006076 RibD C-terminal domain; Region: RibD_C; cl17279 1435356006077 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1435356006078 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1435356006079 short chain dehydrogenase; Provisional; Region: PRK06701 1435356006080 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1435356006081 NAD(P) binding site [chemical binding]; other site 1435356006082 active site 1435356006083 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1435356006084 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1435356006085 NAD(P) binding site [chemical binding]; other site 1435356006086 active site 1435356006087 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1435356006088 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1435356006089 dimerization interface [polypeptide binding]; other site 1435356006090 DPS ferroxidase diiron center [ion binding]; other site 1435356006091 ion pore; other site 1435356006092 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; cl02748 1435356006093 putative methyltransferase; Provisional; Region: PRK14967 1435356006094 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1435356006095 S-adenosylmethionine binding site [chemical binding]; other site 1435356006096 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1435356006097 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1435356006098 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1435356006099 hydrophobic ligand binding site; other site 1435356006100 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1435356006101 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1435356006102 substrate binding site [chemical binding]; other site 1435356006103 ATP binding site [chemical binding]; other site 1435356006104 Survival protein SurE; Region: SurE; pfam01975 1435356006105 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1435356006106 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1435356006107 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1435356006108 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1435356006109 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1435356006110 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1435356006111 iron-sulfur cluster [ion binding]; other site 1435356006112 [2Fe-2S] cluster binding site [ion binding]; other site 1435356006113 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1435356006114 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1435356006115 proposed catalytic triad [active] 1435356006116 conserved cys residue [active] 1435356006117 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1435356006118 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 1435356006119 active site 1435356006120 homotetramer interface [polypeptide binding]; other site 1435356006121 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1435356006122 putative ADP-binding pocket [chemical binding]; other site 1435356006123 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1435356006124 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1435356006125 anti sigma factor interaction site; other site 1435356006126 regulatory phosphorylation site [posttranslational modification]; other site 1435356006127 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1435356006128 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 1435356006129 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1435356006130 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1435356006131 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1435356006132 DNA binding residues [nucleotide binding] 1435356006133 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1435356006134 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1435356006135 putative NAD(P) binding site [chemical binding]; other site 1435356006136 putative substrate binding site [chemical binding]; other site 1435356006137 catalytic Zn binding site [ion binding]; other site 1435356006138 structural Zn binding site [ion binding]; other site 1435356006139 dimer interface [polypeptide binding]; other site 1435356006140 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1435356006141 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1435356006142 THF binding site; other site 1435356006143 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1435356006144 substrate binding site [chemical binding]; other site 1435356006145 THF binding site; other site 1435356006146 zinc-binding site [ion binding]; other site 1435356006147 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 1435356006148 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1435356006149 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1435356006150 isocitrate lyase; Provisional; Region: PRK15063 1435356006151 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1435356006152 tetramer interface [polypeptide binding]; other site 1435356006153 active site 1435356006154 Mg2+/Mn2+ binding site [ion binding]; other site 1435356006155 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1435356006156 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1435356006157 heme-binding site [chemical binding]; other site 1435356006158 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1435356006159 FAD binding pocket [chemical binding]; other site 1435356006160 FAD binding motif [chemical binding]; other site 1435356006161 phosphate binding motif [ion binding]; other site 1435356006162 beta-alpha-beta structure motif; other site 1435356006163 NAD binding pocket [chemical binding]; other site 1435356006164 Heme binding pocket [chemical binding]; other site 1435356006165 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1435356006166 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1435356006167 non-specific DNA binding site [nucleotide binding]; other site 1435356006168 salt bridge; other site 1435356006169 sequence-specific DNA binding site [nucleotide binding]; other site 1435356006170 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1435356006171 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1435356006172 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1435356006173 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1435356006174 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1435356006175 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1435356006176 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 1435356006177 putative ligand binding site [chemical binding]; other site 1435356006178 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1435356006179 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1435356006180 TM-ABC transporter signature motif; other site 1435356006181 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1435356006182 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1435356006183 TM-ABC transporter signature motif; other site 1435356006184 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 1435356006185 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1435356006186 Walker A/P-loop; other site 1435356006187 ATP binding site [chemical binding]; other site 1435356006188 Q-loop/lid; other site 1435356006189 ABC transporter signature motif; other site 1435356006190 Walker B; other site 1435356006191 D-loop; other site 1435356006192 H-loop/switch region; other site 1435356006193 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1435356006194 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1435356006195 Walker A/P-loop; other site 1435356006196 ATP binding site [chemical binding]; other site 1435356006197 Q-loop/lid; other site 1435356006198 ABC transporter signature motif; other site 1435356006199 Walker B; other site 1435356006200 D-loop; other site 1435356006201 H-loop/switch region; other site 1435356006202 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1435356006203 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1435356006204 DNA-binding site [nucleotide binding]; DNA binding site 1435356006205 FCD domain; Region: FCD; pfam07729 1435356006206 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1435356006207 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1435356006208 allophanate hydrolase; Provisional; Region: PRK08186 1435356006209 Amidase; Region: Amidase; cl11426 1435356006210 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 1435356006211 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1435356006212 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1435356006213 putative di-iron ligands [ion binding]; other site 1435356006214 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1435356006215 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1435356006216 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1435356006217 FAD binding pocket [chemical binding]; other site 1435356006218 FAD binding motif [chemical binding]; other site 1435356006219 phosphate binding motif [ion binding]; other site 1435356006220 beta-alpha-beta structure motif; other site 1435356006221 NAD binding pocket [chemical binding]; other site 1435356006222 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1435356006223 catalytic loop [active] 1435356006224 iron binding site [ion binding]; other site 1435356006225 Cupin domain; Region: Cupin_2; cl17218 1435356006226 Predicted transcriptional regulator [Transcription]; Region: COG2345 1435356006227 helix_turn_helix, Arsenical Resistance Operon Repressor; Region: HTH_ARSR; smart00418 1435356006228 putative DNA binding site [nucleotide binding]; other site 1435356006229 putative Zn2+ binding site [ion binding]; other site 1435356006230 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 1435356006231 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1435356006232 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1435356006233 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1435356006234 Hemerythrin-like domain; Region: Hr-like; cd12108 1435356006235 Fe binding site [ion binding]; other site 1435356006236 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1435356006237 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1435356006238 active site 1435356006239 phosphorylation site [posttranslational modification] 1435356006240 intermolecular recognition site; other site 1435356006241 dimerization interface [polypeptide binding]; other site 1435356006242 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1435356006243 DNA binding residues [nucleotide binding] 1435356006244 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1435356006245 Histidine kinase; Region: HisKA_3; pfam07730 1435356006246 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1435356006247 ATP binding site [chemical binding]; other site 1435356006248 Mg2+ binding site [ion binding]; other site 1435356006249 G-X-G motif; other site 1435356006250 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1435356006251 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1435356006252 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1435356006253 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1435356006254 Walker A/P-loop; other site 1435356006255 ATP binding site [chemical binding]; other site 1435356006256 Q-loop/lid; other site 1435356006257 ABC transporter signature motif; other site 1435356006258 Walker B; other site 1435356006259 D-loop; other site 1435356006260 H-loop/switch region; other site 1435356006261 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1435356006262 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1435356006263 NAD(P) binding site [chemical binding]; other site 1435356006264 active site 1435356006265 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1435356006266 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1435356006267 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1435356006268 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1435356006269 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1435356006270 DNA binding site [nucleotide binding] 1435356006271 domain linker motif; other site 1435356006272 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1435356006273 dimerization interface [polypeptide binding]; other site 1435356006274 ligand binding site [chemical binding]; other site 1435356006275 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356006276 metabolite-proton symporter; Region: 2A0106; TIGR00883 1435356006277 putative substrate translocation pore; other site 1435356006278 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1435356006279 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1435356006280 trimer interface [polypeptide binding]; other site 1435356006281 active site 1435356006282 dimer interface [polypeptide binding]; other site 1435356006283 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 1435356006284 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1435356006285 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1435356006286 shikimate binding site; other site 1435356006287 NAD(P) binding site [chemical binding]; other site 1435356006288 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1435356006289 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 1435356006290 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1435356006291 active site 1435356006292 metal binding site [ion binding]; metal-binding site 1435356006293 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1435356006294 active site 1435356006295 metal binding site [ion binding]; metal-binding site 1435356006296 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 1435356006297 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1435356006298 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1435356006299 dimer interface [polypeptide binding]; other site 1435356006300 FMN binding site [chemical binding]; other site 1435356006301 NADPH bind site [chemical binding]; other site 1435356006302 PspC domain; Region: PspC; pfam04024 1435356006303 Putative esterase; Region: Esterase; pfam00756 1435356006304 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1435356006305 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1435356006306 ring oligomerisation interface [polypeptide binding]; other site 1435356006307 ATP/Mg binding site [chemical binding]; other site 1435356006308 stacking interactions; other site 1435356006309 hinge regions; other site 1435356006310 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1435356006311 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1435356006312 active site 1435356006313 motif I; other site 1435356006314 motif II; other site 1435356006315 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1435356006316 heat shock protein 90; Provisional; Region: PRK05218 1435356006317 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1435356006318 ATP binding site [chemical binding]; other site 1435356006319 Mg2+ binding site [ion binding]; other site 1435356006320 G-X-G motif; other site 1435356006321 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1435356006322 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1435356006323 Predicted transcriptional regulators [Transcription]; Region: COG1695 1435356006324 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1435356006325 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1435356006326 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1435356006327 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 1435356006328 RNase_H superfamily; Region: RNase_H_2; pfam13482 1435356006329 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1435356006330 AAA domain; Region: AAA_30; pfam13604 1435356006331 AAA domain; Region: AAA_12; pfam13087 1435356006332 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1435356006333 hydrophobic ligand binding site; other site 1435356006334 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 1435356006335 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1435356006336 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1435356006337 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 1435356006338 Cell division protein 48 (CDC48) N-terminal domain; Region: CDC48_N; smart01073 1435356006339 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 1435356006340 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1435356006341 Walker A motif; other site 1435356006342 ATP binding site [chemical binding]; other site 1435356006343 Walker B motif; other site 1435356006344 arginine finger; other site 1435356006345 Adenovirus IVa2 protein; Region: Adeno_IVa2; pfam02456 1435356006346 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1435356006347 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1435356006348 Walker A motif; other site 1435356006349 ATP binding site [chemical binding]; other site 1435356006350 Walker B motif; other site 1435356006351 arginine finger; other site 1435356006352 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 1435356006353 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1435356006354 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1435356006355 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1435356006356 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 1435356006357 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 1435356006358 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1435356006359 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 1435356006360 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK07948 1435356006361 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 1435356006362 carboxylate-amine ligase; Provisional; Region: PRK13517 1435356006363 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1435356006364 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1435356006365 E-class dimer interface [polypeptide binding]; other site 1435356006366 P-class dimer interface [polypeptide binding]; other site 1435356006367 active site 1435356006368 Cu2+ binding site [ion binding]; other site 1435356006369 Zn2+ binding site [ion binding]; other site 1435356006370 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1435356006371 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 1435356006372 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1435356006373 active site 1435356006374 catalytic residues [active] 1435356006375 metal binding site [ion binding]; metal-binding site 1435356006376 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1435356006377 Coenzyme A binding pocket [chemical binding]; other site 1435356006378 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1435356006379 putative catalytic site [active] 1435356006380 putative phosphate binding site [ion binding]; other site 1435356006381 active site 1435356006382 metal binding site A [ion binding]; metal-binding site 1435356006383 DNA binding site [nucleotide binding] 1435356006384 putative AP binding site [nucleotide binding]; other site 1435356006385 putative metal binding site B [ion binding]; other site 1435356006386 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1435356006387 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1435356006388 dimer interface [polypeptide binding]; other site 1435356006389 substrate binding site [chemical binding]; other site 1435356006390 ATP binding site [chemical binding]; other site 1435356006391 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1435356006392 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 1435356006393 PA/protease or protease-like domain interface [polypeptide binding]; other site 1435356006394 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 1435356006395 Peptidase family M28; Region: Peptidase_M28; pfam04389 1435356006396 active site 1435356006397 metal binding site [ion binding]; metal-binding site 1435356006398 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1435356006399 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1435356006400 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1435356006401 Walker A/P-loop; other site 1435356006402 ATP binding site [chemical binding]; other site 1435356006403 Q-loop/lid; other site 1435356006404 ABC transporter signature motif; other site 1435356006405 Walker B; other site 1435356006406 D-loop; other site 1435356006407 H-loop/switch region; other site 1435356006408 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1435356006409 ThiS interaction site; other site 1435356006410 putative active site [active] 1435356006411 tetramer interface [polypeptide binding]; other site 1435356006412 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1435356006413 thiS-thiF/thiG interaction site; other site 1435356006414 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1435356006415 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1435356006416 thiamine phosphate binding site [chemical binding]; other site 1435356006417 active site 1435356006418 pyrophosphate binding site [ion binding]; other site 1435356006419 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1435356006420 nudix motif; other site 1435356006421 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1435356006422 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1435356006423 substrate binding pocket [chemical binding]; other site 1435356006424 membrane-bound complex binding site; other site 1435356006425 hinge residues; other site 1435356006426 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1435356006427 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1435356006428 active site 1435356006429 ATP binding site [chemical binding]; other site 1435356006430 substrate binding site [chemical binding]; other site 1435356006431 activation loop (A-loop); other site 1435356006432 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1435356006433 propionate/acetate kinase; Provisional; Region: PRK12379 1435356006434 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1435356006435 phosphate acetyltransferase; Reviewed; Region: PRK05632 1435356006436 DRTGG domain; Region: DRTGG; pfam07085 1435356006437 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1435356006438 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 1435356006439 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1435356006440 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1435356006441 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1435356006442 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1435356006443 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 1435356006444 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1435356006445 active site 1435356006446 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1435356006447 non-prolyl cis peptide bond; other site 1435356006448 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1435356006449 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1435356006450 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1435356006451 Walker A/P-loop; other site 1435356006452 ATP binding site [chemical binding]; other site 1435356006453 Q-loop/lid; other site 1435356006454 ABC transporter signature motif; other site 1435356006455 Walker B; other site 1435356006456 D-loop; other site 1435356006457 H-loop/switch region; other site 1435356006458 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1435356006459 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1435356006460 Walker A/P-loop; other site 1435356006461 ATP binding site [chemical binding]; other site 1435356006462 Q-loop/lid; other site 1435356006463 ABC transporter signature motif; other site 1435356006464 Walker B; other site 1435356006465 D-loop; other site 1435356006466 H-loop/switch region; other site 1435356006467 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1435356006468 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1435356006469 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1435356006470 putative PBP binding loops; other site 1435356006471 dimer interface [polypeptide binding]; other site 1435356006472 ABC-ATPase subunit interface; other site 1435356006473 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1435356006474 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1435356006475 dimer interface [polypeptide binding]; other site 1435356006476 conserved gate region; other site 1435356006477 putative PBP binding loops; other site 1435356006478 ABC-ATPase subunit interface; other site 1435356006479 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1435356006480 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 1435356006481 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1435356006482 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1435356006483 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1435356006484 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1435356006485 Coenzyme A binding pocket [chemical binding]; other site 1435356006486 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 1435356006487 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1435356006488 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1435356006489 substrate binding pocket [chemical binding]; other site 1435356006490 membrane-bound complex binding site; other site 1435356006491 hinge residues; other site 1435356006492 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1435356006493 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1435356006494 Walker A/P-loop; other site 1435356006495 ATP binding site [chemical binding]; other site 1435356006496 Q-loop/lid; other site 1435356006497 ABC transporter signature motif; other site 1435356006498 Walker B; other site 1435356006499 D-loop; other site 1435356006500 H-loop/switch region; other site 1435356006501 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1435356006502 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1435356006503 dimer interface [polypeptide binding]; other site 1435356006504 conserved gate region; other site 1435356006505 putative PBP binding loops; other site 1435356006506 ABC-ATPase subunit interface; other site 1435356006507 hypothetical protein; Provisional; Region: PRK10621 1435356006508 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1435356006509 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1435356006510 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1435356006511 homotrimer interface [polypeptide binding]; other site 1435356006512 Walker A motif; other site 1435356006513 GTP binding site [chemical binding]; other site 1435356006514 Walker B motif; other site 1435356006515 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1435356006516 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1435356006517 Walker A/P-loop; other site 1435356006518 ATP binding site [chemical binding]; other site 1435356006519 Q-loop/lid; other site 1435356006520 ABC transporter signature motif; other site 1435356006521 Walker B; other site 1435356006522 D-loop; other site 1435356006523 H-loop/switch region; other site 1435356006524 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1435356006525 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1435356006526 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1435356006527 dimer interface [polypeptide binding]; other site 1435356006528 putative PBP binding regions; other site 1435356006529 ABC-ATPase subunit interface; other site 1435356006530 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 1435356006531 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1435356006532 putative binding site residues; other site 1435356006533 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 1435356006534 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1435356006535 homodimer interface [polypeptide binding]; other site 1435356006536 substrate-cofactor binding pocket; other site 1435356006537 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1435356006538 catalytic residue [active] 1435356006539 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 1435356006540 active site residue [active] 1435356006541 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 1435356006542 ferredoxin-NADP+ reductase; Region: PLN02852 1435356006543 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1435356006544 Protein of unknown function (DUF456); Region: DUF456; pfam04306 1435356006545 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 1435356006546 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 1435356006547 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1435356006548 active site 1435356006549 dimer interface [polypeptide binding]; other site 1435356006550 effector binding site; other site 1435356006551 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1435356006552 TSCPD domain; Region: TSCPD; pfam12637 1435356006553 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1435356006554 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1435356006555 active site 1435356006556 SnoaL-like domain; Region: SnoaL_2; pfam12680 1435356006557 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1435356006558 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1435356006559 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1435356006560 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1435356006561 DNA-binding site [nucleotide binding]; DNA binding site 1435356006562 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1435356006563 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1435356006564 homodimer interface [polypeptide binding]; other site 1435356006565 catalytic residue [active] 1435356006566 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 1435356006567 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1435356006568 putative active site [active] 1435356006569 putative metal binding site [ion binding]; other site 1435356006570 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1435356006571 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1435356006572 GDP-binding site [chemical binding]; other site 1435356006573 ACT binding site; other site 1435356006574 IMP binding site; other site 1435356006575 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1435356006576 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1435356006577 putative metal binding site [ion binding]; other site 1435356006578 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1435356006579 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1435356006580 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 1435356006581 glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047 1435356006582 putative ADP-binding pocket [chemical binding]; other site 1435356006583 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1435356006584 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1435356006585 active site 1435356006586 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1435356006587 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1435356006588 H-loop/switch region; other site 1435356006589 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 1435356006590 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1435356006591 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1435356006592 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1435356006593 Walker A/P-loop; other site 1435356006594 ATP binding site [chemical binding]; other site 1435356006595 Q-loop/lid; other site 1435356006596 ABC transporter signature motif; other site 1435356006597 Walker B; other site 1435356006598 D-loop; other site 1435356006599 H-loop/switch region; other site 1435356006600 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1435356006601 ABC-ATPase subunit interface; other site 1435356006602 dimer interface [polypeptide binding]; other site 1435356006603 putative PBP binding regions; other site 1435356006604 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1435356006605 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1435356006606 dimer interface [polypeptide binding]; other site 1435356006607 putative PBP binding regions; other site 1435356006608 ABC-ATPase subunit interface; other site 1435356006609 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1435356006610 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1435356006611 intersubunit interface [polypeptide binding]; other site 1435356006612 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1435356006613 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1435356006614 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1435356006615 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 1435356006616 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 1435356006617 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1435356006618 substrate binding site [chemical binding]; other site 1435356006619 THF binding site; other site 1435356006620 zinc-binding site [ion binding]; other site 1435356006621 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1435356006622 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1435356006623 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1435356006624 oxidoreductase; Provisional; Region: PRK06128 1435356006625 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1435356006626 NAD binding site [chemical binding]; other site 1435356006627 metal binding site [ion binding]; metal-binding site 1435356006628 active site 1435356006629 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1435356006630 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1435356006631 NAD(P) binding site [chemical binding]; other site 1435356006632 active site 1435356006633 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1435356006634 S-adenosylmethionine binding site [chemical binding]; other site 1435356006635 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 1435356006636 active site 1435356006637 SAM binding site [chemical binding]; other site 1435356006638 homodimer interface [polypeptide binding]; other site 1435356006639 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 1435356006640 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1435356006641 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1435356006642 precorrin-3B synthase; Region: CobG; TIGR02435 1435356006643 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1435356006644 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 1435356006645 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1435356006646 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1435356006647 active site 1435356006648 SAM binding site [chemical binding]; other site 1435356006649 homodimer interface [polypeptide binding]; other site 1435356006650 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1435356006651 active site 1435356006652 SAM binding site [chemical binding]; other site 1435356006653 homodimer interface [polypeptide binding]; other site 1435356006654 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1435356006655 active site 1435356006656 SAM binding site [chemical binding]; other site 1435356006657 homodimer interface [polypeptide binding]; other site 1435356006658 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1435356006659 active site 1435356006660 putative homodimer interface [polypeptide binding]; other site 1435356006661 SAM binding site [chemical binding]; other site 1435356006662 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1435356006663 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1435356006664 S-adenosylmethionine binding site [chemical binding]; other site 1435356006665 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 1435356006666 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1435356006667 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 1435356006668 metal ion-dependent adhesion site (MIDAS); other site 1435356006669 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1435356006670 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1435356006671 homodimer interface [polypeptide binding]; other site 1435356006672 Walker A motif; other site 1435356006673 ATP binding site [chemical binding]; other site 1435356006674 hydroxycobalamin binding site [chemical binding]; other site 1435356006675 Walker B motif; other site 1435356006676 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1435356006677 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1435356006678 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1435356006679 catalytic triad [active] 1435356006680 hypothetical protein; Provisional; Region: PRK07908 1435356006681 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1435356006682 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1435356006683 homodimer interface [polypeptide binding]; other site 1435356006684 catalytic residue [active] 1435356006685 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1435356006686 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 1435356006687 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1435356006688 motif II; other site 1435356006689 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 1435356006690 cobyric acid synthase; Provisional; Region: PRK00784 1435356006691 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1435356006692 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1435356006693 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1435356006694 catalytic triad [active] 1435356006695 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 1435356006696 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1435356006697 catalytic core [active] 1435356006698 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1435356006699 Predicted membrane protein [Function unknown]; Region: COG4129 1435356006700 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1435356006701 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 1435356006702 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1435356006703 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1435356006704 active site 1435356006705 intersubunit interface [polypeptide binding]; other site 1435356006706 zinc binding site [ion binding]; other site 1435356006707 Na+ binding site [ion binding]; other site 1435356006708 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1435356006709 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1435356006710 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 1435356006711 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1435356006712 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1435356006713 short chain dehydrogenase; Provisional; Region: PRK08267 1435356006714 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1435356006715 NAD(P) binding site [chemical binding]; other site 1435356006716 active site 1435356006717 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 1435356006718 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1435356006719 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1435356006720 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1435356006721 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1435356006722 dimer interface [polypeptide binding]; other site 1435356006723 active site 1435356006724 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1435356006725 active site 1435356006726 LemA family; Region: LemA; cl00742 1435356006727 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1435356006728 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1435356006729 NAD(P) binding site [chemical binding]; other site 1435356006730 active site 1435356006731 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1435356006732 Clp amino terminal domain; Region: Clp_N; pfam02861 1435356006733 Clp amino terminal domain; Region: Clp_N; pfam02861 1435356006734 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1435356006735 Walker A motif; other site 1435356006736 ATP binding site [chemical binding]; other site 1435356006737 Walker B motif; other site 1435356006738 arginine finger; other site 1435356006739 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1435356006740 Walker A motif; other site 1435356006741 ATP binding site [chemical binding]; other site 1435356006742 Walker B motif; other site 1435356006743 arginine finger; other site 1435356006744 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1435356006745 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1435356006746 heme-binding site [chemical binding]; other site 1435356006747 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 1435356006748 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 1435356006749 FAD binding pocket [chemical binding]; other site 1435356006750 FAD binding motif [chemical binding]; other site 1435356006751 phosphate binding motif [ion binding]; other site 1435356006752 beta-alpha-beta structure motif; other site 1435356006753 NAD binding pocket [chemical binding]; other site 1435356006754 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1435356006755 acyl-CoA synthetase; Validated; Region: PRK06188 1435356006756 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1435356006757 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1435356006758 acyl-activating enzyme (AAE) consensus motif; other site 1435356006759 acyl-activating enzyme (AAE) consensus motif; other site 1435356006760 putative AMP binding site [chemical binding]; other site 1435356006761 putative active site [active] 1435356006762 putative CoA binding site [chemical binding]; other site 1435356006763 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1435356006764 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 1435356006765 FAD binding pocket [chemical binding]; other site 1435356006766 conserved FAD binding motif [chemical binding]; other site 1435356006767 phosphate binding motif [ion binding]; other site 1435356006768 beta-alpha-beta structure motif; other site 1435356006769 NAD binding pocket [chemical binding]; other site 1435356006770 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12845 1435356006771 Predicted oxidoreductase [General function prediction only]; Region: COG3573 1435356006772 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1435356006773 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1435356006774 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1435356006775 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1435356006776 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1435356006777 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1435356006778 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1435356006779 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1435356006780 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1435356006781 3-ketosteroid-delta-1-dehydrogenase; Provisional; Region: PRK12837 1435356006782 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1435356006783 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 1435356006784 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1435356006785 DNA binding residues [nucleotide binding] 1435356006786 putative dimer interface [polypeptide binding]; other site 1435356006787 chaperone protein DnaJ; Provisional; Region: PRK14279 1435356006788 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1435356006789 HSP70 interaction site [polypeptide binding]; other site 1435356006790 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1435356006791 Zn binding sites [ion binding]; other site 1435356006792 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1435356006793 dimer interface [polypeptide binding]; other site 1435356006794 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1435356006795 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1435356006796 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1435356006797 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1435356006798 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1435356006799 nucleotide binding site [chemical binding]; other site 1435356006800 NEF interaction site [polypeptide binding]; other site 1435356006801 SBD interface [polypeptide binding]; other site 1435356006802 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1435356006803 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1435356006804 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 1435356006805 DNA binding residues [nucleotide binding] 1435356006806 putative dimer interface [polypeptide binding]; other site 1435356006807 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1435356006808 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1435356006809 Dynamin family; Region: Dynamin_N; pfam00350 1435356006810 G1 box; other site 1435356006811 GTP/Mg2+ binding site [chemical binding]; other site 1435356006812 G2 box; other site 1435356006813 Switch I region; other site 1435356006814 G3 box; other site 1435356006815 Switch II region; other site 1435356006816 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1435356006817 G1 box; other site 1435356006818 GTP/Mg2+ binding site [chemical binding]; other site 1435356006819 G2 box; other site 1435356006820 Switch I region; other site 1435356006821 G3 box; other site 1435356006822 Switch II region; other site 1435356006823 G4 box; other site 1435356006824 G5 box; other site 1435356006825 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 1435356006826 nucleotide binding site [chemical binding]; other site 1435356006827 SBD interface [polypeptide binding]; other site 1435356006828 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1435356006829 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1435356006830 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1435356006831 DNA binding residues [nucleotide binding] 1435356006832 dimerization interface [polypeptide binding]; other site 1435356006833 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1435356006834 4Fe-4S binding domain; Region: Fer4; pfam00037 1435356006835 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 1435356006836 Cysteine-rich domain; Region: CCG; pfam02754 1435356006837 Cysteine-rich domain; Region: CCG; pfam02754 1435356006838 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1435356006839 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1435356006840 Predicted esterase [General function prediction only]; Region: COG0627 1435356006841 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 1435356006842 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1435356006843 Di-iron ligands [ion binding]; other site 1435356006844 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1435356006845 DNA-binding site [nucleotide binding]; DNA binding site 1435356006846 RNA-binding motif; other site 1435356006847 aminotransferase AlaT; Validated; Region: PRK09265 1435356006848 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1435356006849 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1435356006850 homodimer interface [polypeptide binding]; other site 1435356006851 catalytic residue [active] 1435356006852 YibE/F-like protein; Region: YibE_F; pfam07907 1435356006853 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1435356006854 nucleotide binding site [chemical binding]; other site 1435356006855 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1435356006856 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1435356006857 active site 1435356006858 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1435356006859 Chain length determinant protein; Region: Wzz; cl15801 1435356006860 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1435356006861 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1435356006862 Condensation domain; Region: Condensation; pfam00668 1435356006863 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1435356006864 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1435356006865 acyl-activating enzyme (AAE) consensus motif; other site 1435356006866 AMP binding site [chemical binding]; other site 1435356006867 Condensation domain; Region: Condensation; pfam00668 1435356006868 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1435356006869 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1435356006870 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1435356006871 acyl-activating enzyme (AAE) consensus motif; other site 1435356006872 AMP binding site [chemical binding]; other site 1435356006873 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1435356006874 Condensation domain; Region: Condensation; pfam00668 1435356006875 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1435356006876 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1435356006877 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1435356006878 acyl-activating enzyme (AAE) consensus motif; other site 1435356006879 AMP binding site [chemical binding]; other site 1435356006880 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1435356006881 Condensation domain; Region: Condensation; pfam00668 1435356006882 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1435356006883 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1435356006884 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1435356006885 acyl-activating enzyme (AAE) consensus motif; other site 1435356006886 AMP binding site [chemical binding]; other site 1435356006887 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1435356006888 Condensation domain; Region: Condensation; pfam00668 1435356006889 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1435356006890 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1435356006891 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1435356006892 acyl-activating enzyme (AAE) consensus motif; other site 1435356006893 AMP binding site [chemical binding]; other site 1435356006894 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1435356006895 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1435356006896 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1435356006897 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1435356006898 acyl-activating enzyme (AAE) consensus motif; other site 1435356006899 AMP binding site [chemical binding]; other site 1435356006900 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1435356006901 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 1435356006902 Winged helix-turn helix; Region: HTH_29; pfam13551 1435356006903 Homeodomain-like domain; Region: HTH_32; pfam13565 1435356006904 Integrase core domain; Region: rve; pfam00665 1435356006905 Integrase core domain; Region: rve_3; pfam13683 1435356006906 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1435356006907 GTP-binding protein; Provisional; Region: PTZ00258 1435356006908 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1435356006909 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 1435356006910 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1435356006911 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1435356006912 substrate binding site; other site 1435356006913 tetramer interface; other site 1435356006914 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1435356006915 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1435356006916 NAD binding site [chemical binding]; other site 1435356006917 substrate binding site [chemical binding]; other site 1435356006918 homodimer interface [polypeptide binding]; other site 1435356006919 active site 1435356006920 Predicted dinucleotide-utilizing enzyme [General function prediction only]; Region: COG1712 1435356006921 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1435356006922 Domain of unknown function DUF108; Region: DUF108; pfam01958 1435356006923 oxidoreductase; Provisional; Region: PRK06128 1435356006924 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1435356006925 NAD binding site [chemical binding]; other site 1435356006926 metal binding site [ion binding]; metal-binding site 1435356006927 active site 1435356006928 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1435356006929 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1435356006930 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1435356006931 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1435356006932 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1435356006933 motif II; other site 1435356006934 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1435356006935 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1435356006936 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1435356006937 active site 1435356006938 phosphorylation site [posttranslational modification] 1435356006939 intermolecular recognition site; other site 1435356006940 dimerization interface [polypeptide binding]; other site 1435356006941 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1435356006942 DNA binding site [nucleotide binding] 1435356006943 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1435356006944 HAMP domain; Region: HAMP; pfam00672 1435356006945 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1435356006946 dimer interface [polypeptide binding]; other site 1435356006947 phosphorylation site [posttranslational modification] 1435356006948 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1435356006949 ATP binding site [chemical binding]; other site 1435356006950 Mg2+ binding site [ion binding]; other site 1435356006951 G-X-G motif; other site 1435356006952 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1435356006953 putative hydrophobic ligand binding site [chemical binding]; other site 1435356006954 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1435356006955 putative hydrolase; Provisional; Region: PRK02113 1435356006956 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1435356006957 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1435356006958 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1435356006959 Bacterial transcriptional regulator; Region: IclR; pfam01614 1435356006960 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1435356006961 Cytochrome P450; Region: p450; cl12078 1435356006962 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1435356006963 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1435356006964 FMN-binding pocket [chemical binding]; other site 1435356006965 flavin binding motif; other site 1435356006966 phosphate binding motif [ion binding]; other site 1435356006967 beta-alpha-beta structure motif; other site 1435356006968 NAD binding pocket [chemical binding]; other site 1435356006969 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1435356006970 catalytic loop [active] 1435356006971 iron binding site [ion binding]; other site 1435356006972 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356006973 metabolite-proton symporter; Region: 2A0106; TIGR00883 1435356006974 putative substrate translocation pore; other site 1435356006975 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1435356006976 dimerization interface [polypeptide binding]; other site 1435356006977 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1435356006978 dimer interface [polypeptide binding]; other site 1435356006979 phosphorylation site [posttranslational modification] 1435356006980 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1435356006981 ATP binding site [chemical binding]; other site 1435356006982 Mg2+ binding site [ion binding]; other site 1435356006983 G-X-G motif; other site 1435356006984 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1435356006985 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1435356006986 active site 1435356006987 phosphorylation site [posttranslational modification] 1435356006988 intermolecular recognition site; other site 1435356006989 dimerization interface [polypeptide binding]; other site 1435356006990 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1435356006991 DNA binding site [nucleotide binding] 1435356006992 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 1435356006993 putative metal binding residues [ion binding]; other site 1435356006994 signature motif; other site 1435356006995 dimer interface [polypeptide binding]; other site 1435356006996 active site 1435356006997 polyP binding site; other site 1435356006998 substrate binding site [chemical binding]; other site 1435356006999 acceptor-phosphate pocket; other site 1435356007000 CotH protein; Region: CotH; pfam08757 1435356007001 enoyl-CoA hydratase; Provisional; Region: PRK06190 1435356007002 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1435356007003 substrate binding site [chemical binding]; other site 1435356007004 oxyanion hole (OAH) forming residues; other site 1435356007005 trimer interface [polypeptide binding]; other site 1435356007006 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1435356007007 CoenzymeA binding site [chemical binding]; other site 1435356007008 subunit interaction site [polypeptide binding]; other site 1435356007009 PHB binding site; other site 1435356007010 Predicted transcriptional regulators [Transcription]; Region: COG1733 1435356007011 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1435356007012 dimerization interface [polypeptide binding]; other site 1435356007013 putative DNA binding site [nucleotide binding]; other site 1435356007014 putative Zn2+ binding site [ion binding]; other site 1435356007015 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1435356007016 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 1435356007017 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1435356007018 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1435356007019 DNA binding residues [nucleotide binding] 1435356007020 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1435356007021 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1435356007022 DNA binding residues [nucleotide binding] 1435356007023 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1435356007024 K+ potassium transporter; Region: K_trans; cl15781 1435356007025 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1435356007026 CoenzymeA binding site [chemical binding]; other site 1435356007027 subunit interaction site [polypeptide binding]; other site 1435356007028 PHB binding site; other site 1435356007029 amino acid transporter; Region: 2A0306; TIGR00909 1435356007030 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1435356007031 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1435356007032 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1435356007033 putative DNA binding site [nucleotide binding]; other site 1435356007034 putative Zn2+ binding site [ion binding]; other site 1435356007035 AsnC family; Region: AsnC_trans_reg; pfam01037 1435356007036 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1435356007037 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 1435356007038 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 1435356007039 NAD binding site [chemical binding]; other site 1435356007040 Phe binding site; other site 1435356007041 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 1435356007042 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1435356007043 dimer interface [polypeptide binding]; other site 1435356007044 PYR/PP interface [polypeptide binding]; other site 1435356007045 TPP binding site [chemical binding]; other site 1435356007046 substrate binding site [chemical binding]; other site 1435356007047 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1435356007048 TPP-binding site [chemical binding]; other site 1435356007049 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 1435356007050 GAF domain; Region: GAF_2; pfam13185 1435356007051 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1435356007052 SPW repeat; Region: SPW; pfam03779 1435356007053 SPW repeat; Region: SPW; pfam03779 1435356007054 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 1435356007055 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 1435356007056 putative NAD(P) binding site [chemical binding]; other site 1435356007057 putative substrate binding site [chemical binding]; other site 1435356007058 catalytic Zn binding site [ion binding]; other site 1435356007059 structural Zn binding site [ion binding]; other site 1435356007060 Hemerythrin-like domain; Region: Hr-like; cd12108 1435356007061 Fe binding site [ion binding]; other site 1435356007062 Predicted membrane protein [Function unknown]; Region: COG2323 1435356007063 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1435356007064 dimanganese center [ion binding]; other site 1435356007065 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1435356007066 Predicted acyl esterases [General function prediction only]; Region: COG2936 1435356007067 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1435356007068 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1435356007069 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1435356007070 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1435356007071 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1435356007072 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1435356007073 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1435356007074 exosortase A system-associated hydrolase 2; Region: hydr2_PEP; TIGR03101 1435356007075 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1435356007076 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1435356007077 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1435356007078 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1435356007079 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1435356007080 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 1435356007081 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 1435356007082 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1435356007083 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 1435356007084 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1435356007085 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1435356007086 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1435356007087 homodimer interface [polypeptide binding]; other site 1435356007088 catalytic residue [active] 1435356007089 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1435356007090 PhoU domain; Region: PhoU; pfam01895 1435356007091 Rdx family; Region: Rdx; cl01407 1435356007092 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1435356007093 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1435356007094 CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427 1435356007095 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1435356007096 DXD motif; other site 1435356007097 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 1435356007098 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 1435356007099 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1435356007100 trimer interface [polypeptide binding]; other site 1435356007101 active site 1435356007102 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356007103 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1435356007104 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1435356007105 catalytic residue [active] 1435356007106 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1435356007107 catalytic residues [active] 1435356007108 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1435356007109 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1435356007110 peroxiredoxin; Region: AhpC; TIGR03137 1435356007111 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1435356007112 dimer interface [polypeptide binding]; other site 1435356007113 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1435356007114 catalytic triad [active] 1435356007115 peroxidatic and resolving cysteines [active] 1435356007116 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1435356007117 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 1435356007118 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1435356007119 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1435356007120 Zn binding site [ion binding]; other site 1435356007121 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1435356007122 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1435356007123 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1435356007124 Proline dehydrogenase; Region: Pro_dh; cl03282 1435356007125 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1435356007126 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1435356007127 NAD(P) binding site [chemical binding]; other site 1435356007128 catalytic residues [active] 1435356007129 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356007130 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1435356007131 putative substrate translocation pore; other site 1435356007132 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1435356007133 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1435356007134 active site 1435356007135 catalytic residue [active] 1435356007136 dimer interface [polypeptide binding]; other site 1435356007137 CrcB-like protein; Region: CRCB; pfam02537 1435356007138 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1435356007139 Cytochrome P450; Region: p450; cl12078 1435356007140 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1435356007141 tetramer interface [polypeptide binding]; other site 1435356007142 TPP-binding site [chemical binding]; other site 1435356007143 heterodimer interface [polypeptide binding]; other site 1435356007144 phosphorylation loop region [posttranslational modification] 1435356007145 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1435356007146 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1435356007147 PYR/PP interface [polypeptide binding]; other site 1435356007148 dimer interface [polypeptide binding]; other site 1435356007149 TPP binding site [chemical binding]; other site 1435356007150 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1435356007151 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1435356007152 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1435356007153 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1435356007154 dimer interface [polypeptide binding]; other site 1435356007155 active site 1435356007156 CoA binding pocket [chemical binding]; other site 1435356007157 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1435356007158 S-adenosylmethionine binding site [chemical binding]; other site 1435356007159 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1435356007160 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1435356007161 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 1435356007162 FAD binding site [chemical binding]; other site 1435356007163 substrate binding site [chemical binding]; other site 1435356007164 catalytic residues [active] 1435356007165 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1435356007166 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1435356007167 VanW like protein; Region: VanW; pfam04294 1435356007168 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 1435356007169 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1435356007170 dimer interface [polypeptide binding]; other site 1435356007171 active site 1435356007172 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 1435356007173 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1435356007174 NAD(P) binding site [chemical binding]; other site 1435356007175 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1435356007176 NAD(P) binding site [chemical binding]; other site 1435356007177 active site 1435356007178 active site 1435356007179 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1435356007180 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1435356007181 active site 2 [active] 1435356007182 active site 1 [active] 1435356007183 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356007184 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356007185 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1435356007186 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1435356007187 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1435356007188 Ligand Binding Site [chemical binding]; other site 1435356007189 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1435356007190 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 1435356007191 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 1435356007192 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1435356007193 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1435356007194 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 1435356007195 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1435356007196 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1435356007197 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1435356007198 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1435356007199 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1435356007200 nucleotide binding site [chemical binding]; other site 1435356007201 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1435356007202 FOG: CBS domain [General function prediction only]; Region: COG0517 1435356007203 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1435356007204 nucleoside/Zn binding site; other site 1435356007205 dimer interface [polypeptide binding]; other site 1435356007206 catalytic motif [active] 1435356007207 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 1435356007208 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1435356007209 NAD binding site [chemical binding]; other site 1435356007210 catalytic residues [active] 1435356007211 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 1435356007212 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1435356007213 trimer interface [polypeptide binding]; other site 1435356007214 active site 1435356007215 substrate binding site [chemical binding]; other site 1435356007216 CoA binding site [chemical binding]; other site 1435356007217 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1435356007218 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1435356007219 dimer interface [polypeptide binding]; other site 1435356007220 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1435356007221 catalytic residue [active] 1435356007222 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1435356007223 hydrophobic ligand binding site; other site 1435356007224 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 1435356007225 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1435356007226 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1435356007227 NAD binding site [chemical binding]; other site 1435356007228 catalytic Zn binding site [ion binding]; other site 1435356007229 structural Zn binding site [ion binding]; other site 1435356007230 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 1435356007231 putative dimer interface [polypeptide binding]; other site 1435356007232 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1435356007233 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 1435356007234 active site 1435356007235 substrate-binding site [chemical binding]; other site 1435356007236 metal-binding site [ion binding] 1435356007237 GTP binding site [chemical binding]; other site 1435356007238 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1435356007239 S-adenosylmethionine binding site [chemical binding]; other site 1435356007240 LabA_like proteins; Region: LabA_like; cd06167 1435356007241 putative metal binding site [ion binding]; other site 1435356007242 MMPL family; Region: MMPL; pfam03176 1435356007243 MMPL family; Region: MMPL; pfam03176 1435356007244 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1435356007245 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1435356007246 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1435356007247 active site 1435356007248 phosphorylation site [posttranslational modification] 1435356007249 intermolecular recognition site; other site 1435356007250 dimerization interface [polypeptide binding]; other site 1435356007251 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1435356007252 DNA binding residues [nucleotide binding] 1435356007253 dimerization interface [polypeptide binding]; other site 1435356007254 Histidine kinase; Region: HisKA_3; pfam07730 1435356007255 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1435356007256 ATP binding site [chemical binding]; other site 1435356007257 G-X-G motif; other site 1435356007258 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1435356007259 dimerization interface [polypeptide binding]; other site 1435356007260 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1435356007261 cyclase homology domain; Region: CHD; cd07302 1435356007262 nucleotidyl binding site; other site 1435356007263 metal binding site [ion binding]; metal-binding site 1435356007264 dimer interface [polypeptide binding]; other site 1435356007265 Predicted integral membrane protein [Function unknown]; Region: COG0392 1435356007266 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1435356007267 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 1435356007268 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1435356007269 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356007270 putative substrate translocation pore; other site 1435356007271 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356007272 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1435356007273 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1435356007274 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1435356007275 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1435356007276 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1435356007277 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1435356007278 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1435356007279 Walker A/P-loop; other site 1435356007280 ATP binding site [chemical binding]; other site 1435356007281 Q-loop/lid; other site 1435356007282 ABC transporter signature motif; other site 1435356007283 Walker B; other site 1435356007284 D-loop; other site 1435356007285 H-loop/switch region; other site 1435356007286 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1435356007287 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1435356007288 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 1435356007289 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356007290 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1435356007291 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1435356007292 active site 1435356007293 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397 1435356007294 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 1435356007295 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356007296 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356007297 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 1435356007298 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1435356007299 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1435356007300 active site 1435356007301 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 1435356007302 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1435356007303 Walker A/P-loop; other site 1435356007304 ATP binding site [chemical binding]; other site 1435356007305 Q-loop/lid; other site 1435356007306 ABC transporter signature motif; other site 1435356007307 Walker B; other site 1435356007308 D-loop; other site 1435356007309 H-loop/switch region; other site 1435356007310 NMT1-like family; Region: NMT1_2; pfam13379 1435356007311 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1435356007312 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1435356007313 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1435356007314 dimer interface [polypeptide binding]; other site 1435356007315 conserved gate region; other site 1435356007316 putative PBP binding loops; other site 1435356007317 ABC-ATPase subunit interface; other site 1435356007318 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 1435356007319 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1435356007320 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1435356007321 PGAP1-like protein; Region: PGAP1; pfam07819 1435356007322 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820 1435356007323 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1435356007324 dimer interface [polypeptide binding]; other site 1435356007325 active site 1435356007326 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1435356007327 substrate binding site [chemical binding]; other site 1435356007328 catalytic residue [active] 1435356007329 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1435356007330 active site 1435356007331 catalytic site [active] 1435356007332 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1435356007333 active site 2 [active] 1435356007334 active site 1 [active] 1435356007335 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1435356007336 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1435356007337 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1435356007338 putative active site [active] 1435356007339 putative catalytic site [active] 1435356007340 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1435356007341 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1435356007342 DNA-binding site [nucleotide binding]; DNA binding site 1435356007343 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1435356007344 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1435356007345 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1435356007346 active site 1435356007347 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1435356007348 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1435356007349 putative active site [active] 1435356007350 putative catalytic site [active] 1435356007351 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1435356007352 active site 2 [active] 1435356007353 active site 1 [active] 1435356007354 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1435356007355 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1435356007356 TPP-binding site [chemical binding]; other site 1435356007357 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1435356007358 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1435356007359 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1435356007360 dimer interface [polypeptide binding]; other site 1435356007361 PYR/PP interface [polypeptide binding]; other site 1435356007362 TPP binding site [chemical binding]; other site 1435356007363 substrate binding site [chemical binding]; other site 1435356007364 Dienelactone hydrolase family; Region: DLH; pfam01738 1435356007365 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1435356007366 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1435356007367 NAD(P) binding site [chemical binding]; other site 1435356007368 active site 1435356007369 Transcription factor WhiB; Region: Whib; pfam02467 1435356007370 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1435356007371 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1435356007372 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356007373 metabolite-proton symporter; Region: 2A0106; TIGR00883 1435356007374 putative substrate translocation pore; other site 1435356007375 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1435356007376 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1435356007377 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1435356007378 dimerization interface [polypeptide binding]; other site 1435356007379 substrate binding pocket [chemical binding]; other site 1435356007380 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1435356007381 Coenzyme A transferase; Region: CoA_trans; cl17247 1435356007382 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; pfam10069 1435356007383 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 1435356007384 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; pfam10069 1435356007385 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1435356007386 anti sigma factor interaction site; other site 1435356007387 regulatory phosphorylation site [posttranslational modification]; other site 1435356007388 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1435356007389 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1435356007390 active site 1435356007391 CoA binding site [chemical binding]; other site 1435356007392 AMP binding site [chemical binding]; other site 1435356007393 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1435356007394 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1435356007395 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1435356007396 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1435356007397 active site 1435356007398 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356007399 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356007400 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1435356007401 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1435356007402 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1435356007403 CoA binding site [chemical binding]; other site 1435356007404 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1435356007405 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1435356007406 active site 1435356007407 enoyl-CoA hydratase; Provisional; Region: PRK09245 1435356007408 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1435356007409 substrate binding site [chemical binding]; other site 1435356007410 oxyanion hole (OAH) forming residues; other site 1435356007411 trimer interface [polypeptide binding]; other site 1435356007412 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1435356007413 ABC1 family; Region: ABC1; cl17513 1435356007414 RNA polymerase factor sigma-70; Validated; Region: PRK08241 1435356007415 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1435356007416 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1435356007417 DNA binding residues [nucleotide binding] 1435356007418 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 1435356007419 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 1435356007420 Histidine kinase; Region: HisKA_3; pfam07730 1435356007421 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1435356007422 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1435356007423 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1435356007424 active site 1435356007425 phosphorylation site [posttranslational modification] 1435356007426 intermolecular recognition site; other site 1435356007427 dimerization interface [polypeptide binding]; other site 1435356007428 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1435356007429 DNA binding residues [nucleotide binding] 1435356007430 dimerization interface [polypeptide binding]; other site 1435356007431 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1435356007432 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1435356007433 CoenzymeA binding site [chemical binding]; other site 1435356007434 subunit interaction site [polypeptide binding]; other site 1435356007435 PHB binding site; other site 1435356007436 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1435356007437 Beta-lactamase; Region: Beta-lactamase; pfam00144 1435356007438 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1435356007439 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1435356007440 active site 1435356007441 Zn binding site [ion binding]; other site 1435356007442 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1435356007443 Peptidase family M23; Region: Peptidase_M23; pfam01551 1435356007444 Cytochrome P450; Region: p450; cl12078 1435356007445 Cytochrome P450; Region: p450; cl12078 1435356007446 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1435356007447 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356007448 metabolite-proton symporter; Region: 2A0106; TIGR00883 1435356007449 putative substrate translocation pore; other site 1435356007450 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 1435356007451 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1435356007452 Cytochrome P450; Region: p450; cl12078 1435356007453 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1435356007454 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356007455 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356007456 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 1435356007457 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1435356007458 EamA-like transporter family; Region: EamA; pfam00892 1435356007459 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1435356007460 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1435356007461 DNA-binding site [nucleotide binding]; DNA binding site 1435356007462 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1435356007463 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1435356007464 homodimer interface [polypeptide binding]; other site 1435356007465 catalytic residue [active] 1435356007466 Transcription factor WhiB; Region: Whib; pfam02467 1435356007467 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1435356007468 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1435356007469 active site 1435356007470 dimer interface [polypeptide binding]; other site 1435356007471 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1435356007472 dimer interface [polypeptide binding]; other site 1435356007473 active site 1435356007474 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 1435356007475 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1435356007476 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1435356007477 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1435356007478 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1435356007479 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1435356007480 dimerization interface [polypeptide binding]; other site 1435356007481 putative DNA binding site [nucleotide binding]; other site 1435356007482 putative Zn2+ binding site [ion binding]; other site 1435356007483 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1435356007484 putative hydrophobic ligand binding site [chemical binding]; other site 1435356007485 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1435356007486 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1435356007487 Walker A/P-loop; other site 1435356007488 ATP binding site [chemical binding]; other site 1435356007489 Q-loop/lid; other site 1435356007490 ABC transporter signature motif; other site 1435356007491 Walker B; other site 1435356007492 D-loop; other site 1435356007493 H-loop/switch region; other site 1435356007494 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1435356007495 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1435356007496 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1435356007497 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1435356007498 dimer interface [polypeptide binding]; other site 1435356007499 conserved gate region; other site 1435356007500 putative PBP binding loops; other site 1435356007501 ABC-ATPase subunit interface; other site 1435356007502 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1435356007503 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1435356007504 dimer interface [polypeptide binding]; other site 1435356007505 conserved gate region; other site 1435356007506 putative PBP binding loops; other site 1435356007507 ABC-ATPase subunit interface; other site 1435356007508 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1435356007509 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1435356007510 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1435356007511 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1435356007512 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1435356007513 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 1435356007514 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1435356007515 CoenzymeA binding site [chemical binding]; other site 1435356007516 subunit interaction site [polypeptide binding]; other site 1435356007517 PHB binding site; other site 1435356007518 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1435356007519 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1435356007520 Ferredoxin [Energy production and conversion]; Region: COG1146 1435356007521 4Fe-4S binding domain; Region: Fer4; pfam00037 1435356007522 ferredoxin-NADP+ reductase; Region: PLN02852 1435356007523 Dodecin; Region: Dodecin; pfam07311 1435356007524 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1435356007525 Beta-lactamase; Region: Beta-lactamase; pfam00144 1435356007526 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 1435356007527 nucleotide binding site [chemical binding]; other site 1435356007528 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 1435356007529 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 1435356007530 active site 1435356007531 DNA binding site [nucleotide binding] 1435356007532 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 1435356007533 DNA binding site [nucleotide binding] 1435356007534 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1435356007535 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1435356007536 active site 1435356007537 catalytic site [active] 1435356007538 substrate binding site [chemical binding]; other site 1435356007539 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1435356007540 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1435356007541 DNA binding residues [nucleotide binding] 1435356007542 dimerization interface [polypeptide binding]; other site 1435356007543 acyl-CoA synthetase; Validated; Region: PRK08162 1435356007544 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 1435356007545 acyl-activating enzyme (AAE) consensus motif; other site 1435356007546 putative active site [active] 1435356007547 AMP binding site [chemical binding]; other site 1435356007548 putative CoA binding site [chemical binding]; other site 1435356007549 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1435356007550 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356007551 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1435356007552 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1435356007553 FAD binding site [chemical binding]; other site 1435356007554 homotetramer interface [polypeptide binding]; other site 1435356007555 substrate binding pocket [chemical binding]; other site 1435356007556 catalytic base [active] 1435356007557 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 1435356007558 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1435356007559 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1435356007560 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1435356007561 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1435356007562 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1435356007563 synthetase active site [active] 1435356007564 NTP binding site [chemical binding]; other site 1435356007565 metal binding site [ion binding]; metal-binding site 1435356007566 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356007567 putative substrate translocation pore; other site 1435356007568 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1435356007569 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1435356007570 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1435356007571 active site 1435356007572 catalytic tetrad [active] 1435356007573 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1435356007574 TIGR03086 family protein; Region: TIGR03086 1435356007575 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1435356007576 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1435356007577 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1435356007578 cyclase homology domain; Region: CHD; cd07302 1435356007579 nucleotidyl binding site; other site 1435356007580 metal binding site [ion binding]; metal-binding site 1435356007581 dimer interface [polypeptide binding]; other site 1435356007582 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1435356007583 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1435356007584 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1435356007585 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1435356007586 Bacterial transcriptional regulator; Region: IclR; pfam01614 1435356007587 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 1435356007588 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1435356007589 homodimer interface [polypeptide binding]; other site 1435356007590 substrate-cofactor binding pocket; other site 1435356007591 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1435356007592 catalytic residue [active] 1435356007593 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1435356007594 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1435356007595 Walker A/P-loop; other site 1435356007596 ATP binding site [chemical binding]; other site 1435356007597 Q-loop/lid; other site 1435356007598 ABC transporter signature motif; other site 1435356007599 Walker B; other site 1435356007600 D-loop; other site 1435356007601 H-loop/switch region; other site 1435356007602 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1435356007603 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1435356007604 Walker A/P-loop; other site 1435356007605 ATP binding site [chemical binding]; other site 1435356007606 Q-loop/lid; other site 1435356007607 ABC transporter signature motif; other site 1435356007608 Walker B; other site 1435356007609 D-loop; other site 1435356007610 H-loop/switch region; other site 1435356007611 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1435356007612 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1435356007613 TM-ABC transporter signature motif; other site 1435356007614 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1435356007615 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1435356007616 TM-ABC transporter signature motif; other site 1435356007617 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1435356007618 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1435356007619 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1435356007620 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1435356007621 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1435356007622 acyl-activating enzyme (AAE) consensus motif; other site 1435356007623 acyl-activating enzyme (AAE) consensus motif; other site 1435356007624 putative AMP binding site [chemical binding]; other site 1435356007625 putative active site [active] 1435356007626 putative CoA binding site [chemical binding]; other site 1435356007627 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 1435356007628 active site 1435356007629 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1435356007630 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1435356007631 intersubunit interface [polypeptide binding]; other site 1435356007632 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1435356007633 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1435356007634 ABC-ATPase subunit interface; other site 1435356007635 dimer interface [polypeptide binding]; other site 1435356007636 putative PBP binding regions; other site 1435356007637 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1435356007638 ABC-ATPase subunit interface; other site 1435356007639 dimer interface [polypeptide binding]; other site 1435356007640 putative PBP binding regions; other site 1435356007641 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1435356007642 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1435356007643 Walker A/P-loop; other site 1435356007644 ATP binding site [chemical binding]; other site 1435356007645 Q-loop/lid; other site 1435356007646 ABC transporter signature motif; other site 1435356007647 Walker B; other site 1435356007648 D-loop; other site 1435356007649 H-loop/switch region; other site 1435356007650 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1435356007651 RNA/DNA hybrid binding site [nucleotide binding]; other site 1435356007652 active site 1435356007653 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1435356007654 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1435356007655 minor groove reading motif; other site 1435356007656 helix-hairpin-helix signature motif; other site 1435356007657 active site 1435356007658 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1435356007659 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1435356007660 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1435356007661 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1435356007662 S-adenosylmethionine binding site [chemical binding]; other site 1435356007663 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1435356007664 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1435356007665 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1435356007666 active site 1435356007667 acyl-CoA synthetase; Validated; Region: PRK08316 1435356007668 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1435356007669 acyl-activating enzyme (AAE) consensus motif; other site 1435356007670 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1435356007671 acyl-activating enzyme (AAE) consensus motif; other site 1435356007672 putative AMP binding site [chemical binding]; other site 1435356007673 putative active site [active] 1435356007674 putative CoA binding site [chemical binding]; other site 1435356007675 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1435356007676 enoyl-CoA hydratase; Validated; Region: PRK08139 1435356007677 substrate binding site [chemical binding]; other site 1435356007678 oxyanion hole (OAH) forming residues; other site 1435356007679 trimer interface [polypeptide binding]; other site 1435356007680 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1435356007681 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1435356007682 NAD(P) binding site [chemical binding]; other site 1435356007683 active site 1435356007684 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1435356007685 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 1435356007686 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 1435356007687 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1435356007688 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1435356007689 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 1435356007690 putative hydrophobic ligand binding site [chemical binding]; other site 1435356007691 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1435356007692 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1435356007693 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1435356007694 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1435356007695 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1435356007696 catalytic loop [active] 1435356007697 iron binding site [ion binding]; other site 1435356007698 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1435356007699 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 1435356007700 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1435356007701 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 1435356007702 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1435356007703 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1435356007704 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1435356007705 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1435356007706 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1435356007707 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1435356007708 Amidase; Region: Amidase; cl11426 1435356007709 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356007710 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1435356007711 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1435356007712 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1435356007713 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 1435356007714 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1435356007715 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1435356007716 Cytochrome P450; Region: p450; cl12078 1435356007717 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1435356007718 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 1435356007719 catalytic loop [active] 1435356007720 iron binding site [ion binding]; other site 1435356007721 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 1435356007722 FAD binding pocket [chemical binding]; other site 1435356007723 FAD binding motif [chemical binding]; other site 1435356007724 phosphate binding motif [ion binding]; other site 1435356007725 beta-alpha-beta structure motif; other site 1435356007726 NAD binding pocket [chemical binding]; other site 1435356007727 N-terminal, non-catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_N_like; cd09013 1435356007728 tetramer interface [polypeptide binding]; other site 1435356007729 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 1435356007730 C-terminal, catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_C_like; cd09014 1435356007731 tetramer interface [polypeptide binding]; other site 1435356007732 active site 1435356007733 metal binding site [ion binding]; metal-binding site 1435356007734 acetaldehyde dehydrogenase; Validated; Region: PRK08300 1435356007735 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1435356007736 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 1435356007737 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1435356007738 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 1435356007739 active site 1435356007740 catalytic residues [active] 1435356007741 metal binding site [ion binding]; metal-binding site 1435356007742 DmpG-like communication domain; Region: DmpG_comm; pfam07836 1435356007743 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1435356007744 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 1435356007745 NAD binding site [chemical binding]; other site 1435356007746 catalytic residues [active] 1435356007747 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1435356007748 classical (c) SDRs; Region: SDR_c; cd05233 1435356007749 NAD(P) binding site [chemical binding]; other site 1435356007750 active site 1435356007751 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1435356007752 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1435356007753 hexamer interface [polypeptide binding]; other site 1435356007754 active site 2 [active] 1435356007755 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1435356007756 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 1435356007757 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 1435356007758 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1435356007759 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1435356007760 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1435356007761 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1435356007762 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1435356007763 HTH-like domain; Region: HTH_21; pfam13276 1435356007764 Integrase core domain; Region: rve; pfam00665 1435356007765 Integrase core domain; Region: rve_3; pfam13683 1435356007766 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1435356007767 Transposase; Region: HTH_Tnp_1; cl17663 1435356007768 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1435356007769 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 1435356007770 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1435356007771 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1435356007772 Bacterial transcriptional regulator; Region: IclR; pfam01614 1435356007773 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 1435356007774 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 1435356007775 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1435356007776 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 1435356007777 putative NAD(P) binding site [chemical binding]; other site 1435356007778 catalytic Zn binding site [ion binding]; other site 1435356007779 acetoin reductases; Region: 23BDH; TIGR02415 1435356007780 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1435356007781 NAD(P) binding site [chemical binding]; other site 1435356007782 active site 1435356007783 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 1435356007784 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1435356007785 tetramer interface [polypeptide binding]; other site 1435356007786 TPP-binding site [chemical binding]; other site 1435356007787 heterodimer interface [polypeptide binding]; other site 1435356007788 phosphorylation loop region [posttranslational modification] 1435356007789 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1435356007790 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1435356007791 alpha subunit interface [polypeptide binding]; other site 1435356007792 TPP binding site [chemical binding]; other site 1435356007793 heterodimer interface [polypeptide binding]; other site 1435356007794 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1435356007795 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1435356007796 E3 interaction surface; other site 1435356007797 lipoyl attachment site [posttranslational modification]; other site 1435356007798 e3 binding domain; Region: E3_binding; pfam02817 1435356007799 dihydrolipoamide acetyltransferase; Provisional; Region: PRK14843 1435356007800 e3 binding domain; Region: E3_binding; pfam02817 1435356007801 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1435356007802 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1435356007803 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1435356007804 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1435356007805 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1435356007806 lipoyl synthase; Provisional; Region: PRK05481 1435356007807 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1435356007808 FeS/SAM binding site; other site 1435356007809 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1435356007810 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1435356007811 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1435356007812 non-specific DNA binding site [nucleotide binding]; other site 1435356007813 salt bridge; other site 1435356007814 sequence-specific DNA binding site [nucleotide binding]; other site 1435356007815 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 1435356007816 benzoate transporter; Region: benE; TIGR00843 1435356007817 Isochorismatase family; Region: Isochorismatase; pfam00857 1435356007818 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1435356007819 catalytic triad [active] 1435356007820 conserved cis-peptide bond; other site 1435356007821 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1435356007822 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1435356007823 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1435356007824 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1435356007825 DNA-binding site [nucleotide binding]; DNA binding site 1435356007826 FCD domain; Region: FCD; pfam07729 1435356007827 metabolite-proton symporter; Region: 2A0106; TIGR00883 1435356007828 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356007829 putative substrate translocation pore; other site 1435356007830 FAD binding domain; Region: FAD_binding_3; pfam01494 1435356007831 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1435356007832 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1435356007833 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365 1435356007834 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1435356007835 putative active site [active] 1435356007836 Fe(II) binding site [ion binding]; other site 1435356007837 putative dimer interface [polypeptide binding]; other site 1435356007838 putative tetramer interface [polypeptide binding]; other site 1435356007839 Pleckstrin homology-like domain; Region: PH-like; cl17171 1435356007840 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1435356007841 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1435356007842 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1435356007843 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356007844 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1435356007845 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1435356007846 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1435356007847 Beta-lactamase; Region: Beta-lactamase; pfam00144 1435356007848 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1435356007849 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1435356007850 Walker A motif; other site 1435356007851 ATP binding site [chemical binding]; other site 1435356007852 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1435356007853 hypothetical protein; Validated; Region: PRK07581 1435356007854 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 1435356007855 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1435356007856 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1435356007857 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1435356007858 succinic semialdehyde dehydrogenase; Region: PLN02278 1435356007859 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1435356007860 tetramerization interface [polypeptide binding]; other site 1435356007861 NAD(P) binding site [chemical binding]; other site 1435356007862 catalytic residues [active] 1435356007863 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1435356007864 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1435356007865 catalytic site [active] 1435356007866 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1435356007867 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1435356007868 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1435356007869 dimerization interface [polypeptide binding]; other site 1435356007870 substrate binding pocket [chemical binding]; other site 1435356007871 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1435356007872 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 1435356007873 dimer interface [polypeptide binding]; other site 1435356007874 NADP binding site [chemical binding]; other site 1435356007875 catalytic residues [active] 1435356007876 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1435356007877 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1435356007878 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1435356007879 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1435356007880 active site 1435356007881 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1435356007882 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1435356007883 Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231 1435356007884 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1435356007885 catalytic Zn binding site [ion binding]; other site 1435356007886 structural Zn binding site [ion binding]; other site 1435356007887 tetramer interface [polypeptide binding]; other site 1435356007888 GAF domain; Region: GAF; pfam01590 1435356007889 GAF domain; Region: GAF_2; pfam13185 1435356007890 Histidine kinase; Region: HisKA_3; pfam07730 1435356007891 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1435356007892 Mg2+ binding site [ion binding]; other site 1435356007893 G-X-G motif; other site 1435356007894 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1435356007895 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1435356007896 active site 1435356007897 phosphorylation site [posttranslational modification] 1435356007898 intermolecular recognition site; other site 1435356007899 dimerization interface [polypeptide binding]; other site 1435356007900 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1435356007901 DNA binding residues [nucleotide binding] 1435356007902 dimerization interface [polypeptide binding]; other site 1435356007903 metabolite-proton symporter; Region: 2A0106; TIGR00883 1435356007904 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356007905 putative substrate translocation pore; other site 1435356007906 classical (c) SDRs; Region: SDR_c; cd05233 1435356007907 NAD(P) binding site [chemical binding]; other site 1435356007908 active site 1435356007909 TrkA-N domain; Region: TrkA_N; pfam02254 1435356007910 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1435356007911 ThiC-associated domain; Region: ThiC-associated; pfam13667 1435356007912 ThiC family; Region: ThiC; pfam01964 1435356007913 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1435356007914 dimerization interface [polypeptide binding]; other site 1435356007915 putative DNA binding site [nucleotide binding]; other site 1435356007916 putative Zn2+ binding site [ion binding]; other site 1435356007917 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1435356007918 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1435356007919 Walker A motif; other site 1435356007920 ATP binding site [chemical binding]; other site 1435356007921 Walker B motif; other site 1435356007922 arginine finger; other site 1435356007923 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1435356007924 YCII-related domain; Region: YCII; cl00999 1435356007925 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1435356007926 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 1435356007927 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 1435356007928 acyl-activating enzyme (AAE) consensus motif; other site 1435356007929 putative AMP binding site [chemical binding]; other site 1435356007930 putative active site [active] 1435356007931 putative CoA binding site [chemical binding]; other site 1435356007932 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1435356007933 Acyl-CoA dehydrogenase, C-terminal domain; Region: Acyl-CoA_dh_1; pfam00441 1435356007934 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1435356007935 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1435356007936 active site 1435356007937 enoyl-CoA hydratase; Provisional; Region: PRK06495 1435356007938 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1435356007939 substrate binding site [chemical binding]; other site 1435356007940 oxyanion hole (OAH) forming residues; other site 1435356007941 trimer interface [polypeptide binding]; other site 1435356007942 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1435356007943 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1435356007944 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356007945 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356007946 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356007947 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356007948 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1435356007949 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1435356007950 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1435356007951 dimerization interface [polypeptide binding]; other site 1435356007952 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1435356007953 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1435356007954 tetrameric interface [polypeptide binding]; other site 1435356007955 NAD binding site [chemical binding]; other site 1435356007956 catalytic residues [active] 1435356007957 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194 1435356007958 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1435356007959 putative active site [active] 1435356007960 metal binding site [ion binding]; metal-binding site 1435356007961 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1435356007962 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1435356007963 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1435356007964 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1435356007965 active site 1435356007966 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1435356007967 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1435356007968 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1435356007969 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1435356007970 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1435356007971 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1435356007972 YCII-related domain; Region: YCII; cl00999 1435356007973 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1435356007974 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1435356007975 enoyl-CoA hydratase; Provisional; Region: PRK09245 1435356007976 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1435356007977 substrate binding site [chemical binding]; other site 1435356007978 oxyanion hole (OAH) forming residues; other site 1435356007979 trimer interface [polypeptide binding]; other site 1435356007980 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1435356007981 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1435356007982 substrate binding pocket [chemical binding]; other site 1435356007983 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1435356007984 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 1435356007985 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1435356007986 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1435356007987 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1435356007988 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1435356007989 putative NADH binding site [chemical binding]; other site 1435356007990 putative active site [active] 1435356007991 nudix motif; other site 1435356007992 putative metal binding site [ion binding]; other site 1435356007993 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1435356007994 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1435356007995 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1435356007996 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1435356007997 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1435356007998 active site 1435356007999 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1435356008000 NACHT domain; Region: NACHT; pfam05729 1435356008001 Walker A motif; other site 1435356008002 ATP binding site [chemical binding]; other site 1435356008003 Walker B motif; other site 1435356008004 arginine finger; other site 1435356008005 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1435356008006 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1435356008007 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1435356008008 acyl-activating enzyme (AAE) consensus motif; other site 1435356008009 AMP binding site [chemical binding]; other site 1435356008010 active site 1435356008011 CoA binding site [chemical binding]; other site 1435356008012 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1435356008013 Strictosidine synthase; Region: Str_synth; pfam03088 1435356008014 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1435356008015 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1435356008016 FMN binding site [chemical binding]; other site 1435356008017 substrate binding site [chemical binding]; other site 1435356008018 putative catalytic residue [active] 1435356008019 enoyl-CoA hydratase; Provisional; Region: PRK08260 1435356008020 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1435356008021 substrate binding site [chemical binding]; other site 1435356008022 oxyanion hole (OAH) forming residues; other site 1435356008023 trimer interface [polypeptide binding]; other site 1435356008024 RES domain; Region: RES; pfam08808 1435356008025 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1435356008026 ATP binding site [chemical binding]; other site 1435356008027 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1435356008028 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1435356008029 MOSC domain; Region: MOSC; pfam03473 1435356008030 acyl-CoA synthetase; Validated; Region: PRK07787 1435356008031 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1435356008032 acyl-activating enzyme (AAE) consensus motif; other site 1435356008033 AMP binding site [chemical binding]; other site 1435356008034 active site 1435356008035 CoA binding site [chemical binding]; other site 1435356008036 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1435356008037 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1435356008038 Bacterial transcriptional regulator; Region: IclR; pfam01614 1435356008039 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1435356008040 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1435356008041 non-specific DNA binding site [nucleotide binding]; other site 1435356008042 salt bridge; other site 1435356008043 sequence-specific DNA binding site [nucleotide binding]; other site 1435356008044 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 1435356008045 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 1435356008046 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1435356008047 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 1435356008048 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1435356008049 MarR family; Region: MarR_2; pfam12802 1435356008050 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1435356008051 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1435356008052 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1435356008053 Histidine kinase; Region: HisKA_3; pfam07730 1435356008054 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1435356008055 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1435356008056 active site 1435356008057 phosphorylation site [posttranslational modification] 1435356008058 intermolecular recognition site; other site 1435356008059 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1435356008060 DNA binding residues [nucleotide binding] 1435356008061 dimerization interface [polypeptide binding]; other site 1435356008062 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1435356008063 Protein of unknown function (DUF3533); Region: DUF3533; pfam12051 1435356008064 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1435356008065 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 1435356008066 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 1435356008067 active site 1435356008068 DNA binding site [nucleotide binding] 1435356008069 catalytic site [active] 1435356008070 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1435356008071 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1435356008072 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1435356008073 minor groove reading motif; other site 1435356008074 helix-hairpin-helix signature motif; other site 1435356008075 active site 1435356008076 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1435356008077 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1435356008078 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1435356008079 DNA binding site [nucleotide binding] 1435356008080 active site 1435356008081 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1435356008082 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1435356008083 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1435356008084 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1435356008085 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1435356008086 DNA binding site [nucleotide binding] 1435356008087 active site 1435356008088 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356008089 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1435356008090 Cytochrome P450; Region: p450; cl12078 1435356008091 short chain dehydrogenase; Provisional; Region: PRK07326 1435356008092 classical (c) SDRs; Region: SDR_c; cd05233 1435356008093 NAD(P) binding site [chemical binding]; other site 1435356008094 active site 1435356008095 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1435356008096 Phosphotransferase enzyme family; Region: APH; pfam01636 1435356008097 putative active site [active] 1435356008098 putative substrate binding site [chemical binding]; other site 1435356008099 ATP binding site [chemical binding]; other site 1435356008100 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1435356008101 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1435356008102 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1435356008103 active site 1435356008104 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356008105 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356008106 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 1435356008107 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1435356008108 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1435356008109 NAD binding site [chemical binding]; other site 1435356008110 catalytic Zn binding site [ion binding]; other site 1435356008111 substrate binding site [chemical binding]; other site 1435356008112 structural Zn binding site [ion binding]; other site 1435356008113 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1435356008114 hydrophobic ligand binding site; other site 1435356008115 DDE superfamily endonuclease; Region: DDE_5; pfam13546 1435356008116 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 1435356008117 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1435356008118 dimer interface [polypeptide binding]; other site 1435356008119 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1435356008120 active site 1435356008121 Fe binding site [ion binding]; other site 1435356008122 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1435356008123 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1435356008124 AsnC family; Region: AsnC_trans_reg; pfam01037 1435356008125 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1435356008126 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1435356008127 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 1435356008128 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1435356008129 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1435356008130 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1435356008131 active site 1435356008132 metal binding site [ion binding]; metal-binding site 1435356008133 RibD C-terminal domain; Region: RibD_C; cl17279 1435356008134 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356008135 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356008136 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1435356008137 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1435356008138 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1435356008139 non-specific DNA binding site [nucleotide binding]; other site 1435356008140 salt bridge; other site 1435356008141 sequence-specific DNA binding site [nucleotide binding]; other site 1435356008142 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1435356008143 S-adenosylmethionine binding site [chemical binding]; other site 1435356008144 DinB superfamily; Region: DinB_2; pfam12867 1435356008145 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1435356008146 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1435356008147 putative active site [active] 1435356008148 PASTA domain; Region: PASTA; pfam03793 1435356008149 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 1435356008150 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 1435356008151 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 1435356008152 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1435356008153 active site 1435356008154 catalytic triad [active] 1435356008155 oxyanion hole [active] 1435356008156 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1435356008157 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1435356008158 active site 1435356008159 ATP binding site [chemical binding]; other site 1435356008160 substrate binding site [chemical binding]; other site 1435356008161 activation loop (A-loop); other site 1435356008162 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1435356008163 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1435356008164 DNA binding site [nucleotide binding] 1435356008165 domain linker motif; other site 1435356008166 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1435356008167 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1435356008168 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1435356008169 active site 1435356008170 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1435356008171 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1435356008172 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 1435356008173 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1435356008174 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1435356008175 NAD(P) binding site [chemical binding]; other site 1435356008176 active site 1435356008177 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1435356008178 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1435356008179 NAD(P) binding site [chemical binding]; other site 1435356008180 active site 1435356008181 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356008182 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356008183 PPE family; Region: PPE; pfam00823 1435356008184 EspG family; Region: ESX-1_EspG; pfam14011 1435356008185 Domain of unknown function (DUF309); Region: DUF309; pfam03745 1435356008186 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 1435356008187 SnoaL-like domain; Region: SnoaL_4; pfam13577 1435356008188 short chain dehydrogenase; Provisional; Region: PRK08303 1435356008189 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1435356008190 NAD(P) binding site [chemical binding]; other site 1435356008191 active site 1435356008192 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1435356008193 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1435356008194 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1435356008195 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1435356008196 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 1435356008197 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 1435356008198 tetramer interface [polypeptide binding]; other site 1435356008199 active site 1435356008200 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1435356008201 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1435356008202 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 1435356008203 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1435356008204 Bacterial transcriptional regulator; Region: IclR; pfam01614 1435356008205 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 1435356008206 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1435356008207 dimer interface [polypeptide binding]; other site 1435356008208 active site 1435356008209 Predicted membrane protein [Function unknown]; Region: COG4270 1435356008210 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1435356008211 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1435356008212 NAD(P) binding site [chemical binding]; other site 1435356008213 substrate binding site [chemical binding]; other site 1435356008214 dimer interface [polypeptide binding]; other site 1435356008215 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 1435356008216 Domain of unknown function (DUF1839); Region: DUF1839; pfam08893 1435356008217 hypothetical protein; Validated; Region: PRK07080 1435356008218 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1435356008219 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1435356008220 active site 1435356008221 acyl carrier protein; Provisional; Region: PRK07081 1435356008222 Phosphopantetheinyl transferase (holo-ACP synthase) [Lipid metabolism]; Region: AcpS; COG0736 1435356008223 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1435356008224 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1435356008225 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1435356008226 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1435356008227 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1435356008228 dimerization interface [polypeptide binding]; other site 1435356008229 Predicted transcriptional regulators [Transcription]; Region: COG1695 1435356008230 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1435356008231 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1435356008232 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1435356008233 iron-sulfur cluster [ion binding]; other site 1435356008234 [2Fe-2S] cluster binding site [ion binding]; other site 1435356008235 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 1435356008236 alpha subunit interface [polypeptide binding]; other site 1435356008237 active site 1435356008238 substrate binding site [chemical binding]; other site 1435356008239 Fe binding site [ion binding]; other site 1435356008240 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1435356008241 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1435356008242 FMN-binding pocket [chemical binding]; other site 1435356008243 flavin binding motif; other site 1435356008244 phosphate binding motif [ion binding]; other site 1435356008245 beta-alpha-beta structure motif; other site 1435356008246 NAD binding pocket [chemical binding]; other site 1435356008247 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1435356008248 catalytic loop [active] 1435356008249 iron binding site [ion binding]; other site 1435356008250 benzoate transport; Region: 2A0115; TIGR00895 1435356008251 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356008252 putative substrate translocation pore; other site 1435356008253 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356008254 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1435356008255 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1435356008256 Walker A/P-loop; other site 1435356008257 ATP binding site [chemical binding]; other site 1435356008258 Q-loop/lid; other site 1435356008259 ABC transporter signature motif; other site 1435356008260 Walker B; other site 1435356008261 D-loop; other site 1435356008262 H-loop/switch region; other site 1435356008263 ABC transporter; Region: ABC_tran_2; pfam12848 1435356008264 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1435356008265 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 1435356008266 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1435356008267 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1435356008268 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1435356008269 nucleophilic elbow; other site 1435356008270 catalytic triad; other site 1435356008271 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1435356008272 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1435356008273 putative active site [active] 1435356008274 metal binding site [ion binding]; metal-binding site 1435356008275 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1435356008276 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1435356008277 PglZ domain; Region: PglZ; pfam08665 1435356008278 Muconolactone delta-isomerase; Region: MIase; pfam02426 1435356008279 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 1435356008280 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 1435356008281 octamer interface [polypeptide binding]; other site 1435356008282 active site 1435356008283 catechol 1,2-dioxygenase, Actinobacterial; Region: catachol_actin; TIGR02438 1435356008284 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1435356008285 active site 1435356008286 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 1435356008287 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1435356008288 Bacterial transcriptional regulator; Region: IclR; pfam01614 1435356008289 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1435356008290 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1435356008291 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1435356008292 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1435356008293 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 1435356008294 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 1435356008295 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1435356008296 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1435356008297 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1435356008298 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1435356008299 Cytochrome P450; Region: p450; cl12078 1435356008300 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1435356008301 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 1435356008302 catalytic loop [active] 1435356008303 iron binding site [ion binding]; other site 1435356008304 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 1435356008305 FAD binding pocket [chemical binding]; other site 1435356008306 FAD binding motif [chemical binding]; other site 1435356008307 phosphate binding motif [ion binding]; other site 1435356008308 beta-alpha-beta structure motif; other site 1435356008309 NAD binding pocket [chemical binding]; other site 1435356008310 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 1435356008311 Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542 1435356008312 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 1435356008313 putative alpha subunit interface [polypeptide binding]; other site 1435356008314 putative active site [active] 1435356008315 putative substrate binding site [chemical binding]; other site 1435356008316 Fe binding site [ion binding]; other site 1435356008317 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1435356008318 inter-subunit interface; other site 1435356008319 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 1435356008320 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1435356008321 catalytic loop [active] 1435356008322 iron binding site [ion binding]; other site 1435356008323 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 1435356008324 FAD binding pocket [chemical binding]; other site 1435356008325 FAD binding motif [chemical binding]; other site 1435356008326 phosphate binding motif [ion binding]; other site 1435356008327 beta-alpha-beta structure motif; other site 1435356008328 NAD binding pocket [chemical binding]; other site 1435356008329 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1435356008330 FCD domain; Region: FCD; pfam07729 1435356008331 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 1435356008332 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937 1435356008333 putative NAD(P) binding site [chemical binding]; other site 1435356008334 active site 1435356008335 benzoate transport; Region: 2A0115; TIGR00895 1435356008336 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356008337 putative substrate translocation pore; other site 1435356008338 AAA ATPase domain; Region: AAA_16; pfam13191 1435356008339 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1435356008340 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1435356008341 DNA binding residues [nucleotide binding] 1435356008342 dimerization interface [polypeptide binding]; other site 1435356008343 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 1435356008344 benzoate transporter; Region: benE; TIGR00843 1435356008345 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1435356008346 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 1435356008347 Walker A/P-loop; other site 1435356008348 ATP binding site [chemical binding]; other site 1435356008349 Q-loop/lid; other site 1435356008350 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1435356008351 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1435356008352 Walker A/P-loop; other site 1435356008353 ATP binding site [chemical binding]; other site 1435356008354 Q-loop/lid; other site 1435356008355 ABC transporter signature motif; other site 1435356008356 Walker B; other site 1435356008357 D-loop; other site 1435356008358 H-loop/switch region; other site 1435356008359 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1435356008360 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1435356008361 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1435356008362 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1435356008363 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439 1435356008364 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1435356008365 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1435356008366 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 1435356008367 putative FMN binding site [chemical binding]; other site 1435356008368 AAA ATPase domain; Region: AAA_16; pfam13191 1435356008369 AAA domain; Region: AAA_22; pfam13401 1435356008370 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1435356008371 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 1435356008372 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1435356008373 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 1435356008374 2-isopropylmalate synthase; Validated; Region: PRK03739 1435356008375 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1435356008376 active site 1435356008377 catalytic residues [active] 1435356008378 metal binding site [ion binding]; metal-binding site 1435356008379 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1435356008380 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1435356008381 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1435356008382 DNA-binding site [nucleotide binding]; DNA binding site 1435356008383 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1435356008384 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1435356008385 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1435356008386 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1435356008387 active site 2 [active] 1435356008388 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 1435356008389 active site 1435356008390 Lsr2; Region: Lsr2; pfam11774 1435356008391 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1435356008392 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1435356008393 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1435356008394 Protein of unknown function DUF72; Region: DUF72; pfam01904 1435356008395 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1435356008396 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1435356008397 GYD domain; Region: GYD; pfam08734 1435356008398 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356008399 putative substrate translocation pore; other site 1435356008400 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1435356008401 acyl-CoA synthetase; Validated; Region: PRK06164 1435356008402 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1435356008403 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1435356008404 acyl-activating enzyme (AAE) consensus motif; other site 1435356008405 AMP binding site [chemical binding]; other site 1435356008406 active site 1435356008407 CoA binding site [chemical binding]; other site 1435356008408 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1435356008409 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1435356008410 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1435356008411 active site 1 [active] 1435356008412 active site 2 [active] 1435356008413 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1435356008414 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1435356008415 active site 1435356008416 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356008417 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356008418 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1435356008419 Protein of unknown function, DUF485; Region: DUF485; pfam04341 1435356008420 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1435356008421 Na binding site [ion binding]; other site 1435356008422 Phosphotransferase enzyme family; Region: APH; pfam01636 1435356008423 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1435356008424 putative active site [active] 1435356008425 putative substrate binding site [chemical binding]; other site 1435356008426 ATP binding site [chemical binding]; other site 1435356008427 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1435356008428 active site 1435356008429 metal binding site [ion binding]; metal-binding site 1435356008430 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1435356008431 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1435356008432 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1435356008433 active site 1435356008434 amino acid transporter; Region: 2A0306; TIGR00909 1435356008435 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 1435356008436 TspO/MBR family; Region: TspO_MBR; pfam03073 1435356008437 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1435356008438 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1435356008439 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1435356008440 putative molybdopterin cofactor binding site [chemical binding]; other site 1435356008441 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1435356008442 putative molybdopterin cofactor binding site; other site 1435356008443 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 1435356008444 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1435356008445 active site 1435356008446 FMN binding site [chemical binding]; other site 1435356008447 substrate binding site [chemical binding]; other site 1435356008448 3Fe-4S cluster binding site [ion binding]; other site 1435356008449 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1435356008450 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1435356008451 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1435356008452 Walker A/P-loop; other site 1435356008453 ATP binding site [chemical binding]; other site 1435356008454 Q-loop/lid; other site 1435356008455 ABC transporter signature motif; other site 1435356008456 Walker B; other site 1435356008457 D-loop; other site 1435356008458 H-loop/switch region; other site 1435356008459 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1435356008460 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1435356008461 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1435356008462 dimer interface [polypeptide binding]; other site 1435356008463 conserved gate region; other site 1435356008464 putative PBP binding loops; other site 1435356008465 ABC-ATPase subunit interface; other site 1435356008466 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1435356008467 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1435356008468 dimer interface [polypeptide binding]; other site 1435356008469 conserved gate region; other site 1435356008470 putative PBP binding loops; other site 1435356008471 ABC-ATPase subunit interface; other site 1435356008472 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1435356008473 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1435356008474 bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192 1435356008475 Urease, gamma subunit; Region: Urease_gamma; pfam00547 1435356008476 alpha-gamma subunit interface [polypeptide binding]; other site 1435356008477 beta-gamma subunit interface [polypeptide binding]; other site 1435356008478 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1435356008479 alpha-beta subunit interface [polypeptide binding]; other site 1435356008480 urease subunit alpha; Reviewed; Region: ureC; PRK13308 1435356008481 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1435356008482 subunit interactions [polypeptide binding]; other site 1435356008483 active site 1435356008484 flap region; other site 1435356008485 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1435356008486 UreD urease accessory protein; Region: UreD; pfam01774 1435356008487 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 1435356008488 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 1435356008489 dimer interface [polypeptide binding]; other site 1435356008490 catalytic residues [active] 1435356008491 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1435356008492 UreF; Region: UreF; pfam01730 1435356008493 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1435356008494 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 1435356008495 putative ligand binding site [chemical binding]; other site 1435356008496 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1435356008497 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1435356008498 TM-ABC transporter signature motif; other site 1435356008499 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1435356008500 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1435356008501 TM-ABC transporter signature motif; other site 1435356008502 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 1435356008503 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1435356008504 Walker A/P-loop; other site 1435356008505 ATP binding site [chemical binding]; other site 1435356008506 Q-loop/lid; other site 1435356008507 ABC transporter signature motif; other site 1435356008508 Walker B; other site 1435356008509 D-loop; other site 1435356008510 H-loop/switch region; other site 1435356008511 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1435356008512 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1435356008513 Walker A/P-loop; other site 1435356008514 ATP binding site [chemical binding]; other site 1435356008515 Q-loop/lid; other site 1435356008516 ABC transporter signature motif; other site 1435356008517 Walker B; other site 1435356008518 D-loop; other site 1435356008519 H-loop/switch region; other site 1435356008520 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1435356008521 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1435356008522 DNA-binding site [nucleotide binding]; DNA binding site 1435356008523 FCD domain; Region: FCD; pfam07729 1435356008524 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1435356008525 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1435356008526 allophanate hydrolase; Provisional; Region: PRK08186 1435356008527 Amidase; Region: Amidase; cl11426 1435356008528 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 1435356008529 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1435356008530 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1435356008531 putative di-iron ligands [ion binding]; other site 1435356008532 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1435356008533 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1435356008534 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1435356008535 FAD binding pocket [chemical binding]; other site 1435356008536 FAD binding motif [chemical binding]; other site 1435356008537 phosphate binding motif [ion binding]; other site 1435356008538 beta-alpha-beta structure motif; other site 1435356008539 NAD binding pocket [chemical binding]; other site 1435356008540 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1435356008541 catalytic loop [active] 1435356008542 iron binding site [ion binding]; other site 1435356008543 Cupin domain; Region: Cupin_2; cl17218 1435356008544 Predicted transcriptional regulator [Transcription]; Region: COG2345 1435356008545 helix_turn_helix, Arsenical Resistance Operon Repressor; Region: HTH_ARSR; smart00418 1435356008546 putative DNA binding site [nucleotide binding]; other site 1435356008547 putative Zn2+ binding site [ion binding]; other site 1435356008548 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 1435356008549 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1435356008550 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1435356008551 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1435356008552 Hemerythrin-like domain; Region: Hr-like; cd12108 1435356008553 Fe binding site [ion binding]; other site 1435356008554 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1435356008555 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1435356008556 active site 1435356008557 phosphorylation site [posttranslational modification] 1435356008558 intermolecular recognition site; other site 1435356008559 dimerization interface [polypeptide binding]; other site 1435356008560 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1435356008561 DNA binding residues [nucleotide binding] 1435356008562 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1435356008563 Histidine kinase; Region: HisKA_3; pfam07730 1435356008564 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1435356008565 ATP binding site [chemical binding]; other site 1435356008566 Mg2+ binding site [ion binding]; other site 1435356008567 G-X-G motif; other site 1435356008568 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1435356008569 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1435356008570 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1435356008571 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1435356008572 Walker A/P-loop; other site 1435356008573 ATP binding site [chemical binding]; other site 1435356008574 Q-loop/lid; other site 1435356008575 ABC transporter signature motif; other site 1435356008576 Walker B; other site 1435356008577 D-loop; other site 1435356008578 H-loop/switch region; other site 1435356008579 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1435356008580 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1435356008581 NAD(P) binding site [chemical binding]; other site 1435356008582 active site 1435356008583 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1435356008584 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1435356008585 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1435356008586 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1435356008587 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1435356008588 DNA binding site [nucleotide binding] 1435356008589 domain linker motif; other site 1435356008590 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1435356008591 dimerization interface [polypeptide binding]; other site 1435356008592 ligand binding site [chemical binding]; other site 1435356008593 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356008594 metabolite-proton symporter; Region: 2A0106; TIGR00883 1435356008595 putative substrate translocation pore; other site 1435356008596 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1435356008597 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1435356008598 trimer interface [polypeptide binding]; other site 1435356008599 active site 1435356008600 dimer interface [polypeptide binding]; other site 1435356008601 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 1435356008602 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1435356008603 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1435356008604 shikimate binding site; other site 1435356008605 NAD(P) binding site [chemical binding]; other site 1435356008606 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1435356008607 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 1435356008608 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1435356008609 active site 1435356008610 metal binding site [ion binding]; metal-binding site 1435356008611 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1435356008612 active site 1435356008613 metal binding site [ion binding]; metal-binding site 1435356008614 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 1435356008615 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1435356008616 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1435356008617 dimer interface [polypeptide binding]; other site 1435356008618 FMN binding site [chemical binding]; other site 1435356008619 NADPH bind site [chemical binding]; other site 1435356008620 PspC domain; Region: PspC; pfam04024 1435356008621 Putative esterase; Region: Esterase; pfam00756 1435356008622 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1435356008623 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1435356008624 ring oligomerisation interface [polypeptide binding]; other site 1435356008625 ATP/Mg binding site [chemical binding]; other site 1435356008626 stacking interactions; other site 1435356008627 hinge regions; other site 1435356008628 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1435356008629 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1435356008630 active site 1435356008631 motif I; other site 1435356008632 motif II; other site 1435356008633 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1435356008634 heat shock protein 90; Provisional; Region: PRK05218 1435356008635 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1435356008636 ATP binding site [chemical binding]; other site 1435356008637 Mg2+ binding site [ion binding]; other site 1435356008638 G-X-G motif; other site 1435356008639 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1435356008640 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1435356008641 Predicted transcriptional regulators [Transcription]; Region: COG1695 1435356008642 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1435356008643 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1435356008644 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1435356008645 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 1435356008646 RNase_H superfamily; Region: RNase_H_2; pfam13482 1435356008647 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1435356008648 AAA domain; Region: AAA_30; pfam13604 1435356008649 AAA domain; Region: AAA_12; pfam13087 1435356008650 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1435356008651 hydrophobic ligand binding site; other site 1435356008652 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 1435356008653 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1435356008654 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1435356008655 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 1435356008656 Cell division protein 48 (CDC48) N-terminal domain; Region: CDC48_N; smart01073 1435356008657 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 1435356008658 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1435356008659 Walker A motif; other site 1435356008660 ATP binding site [chemical binding]; other site 1435356008661 Walker B motif; other site 1435356008662 arginine finger; other site 1435356008663 Adenovirus IVa2 protein; Region: Adeno_IVa2; pfam02456 1435356008664 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1435356008665 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1435356008666 Walker A motif; other site 1435356008667 ATP binding site [chemical binding]; other site 1435356008668 Walker B motif; other site 1435356008669 arginine finger; other site 1435356008670 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 1435356008671 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1435356008672 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1435356008673 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1435356008674 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 1435356008675 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 1435356008676 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1435356008677 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 1435356008678 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK07948 1435356008679 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 1435356008680 carboxylate-amine ligase; Provisional; Region: PRK13517 1435356008681 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1435356008682 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1435356008683 E-class dimer interface [polypeptide binding]; other site 1435356008684 P-class dimer interface [polypeptide binding]; other site 1435356008685 active site 1435356008686 Cu2+ binding site [ion binding]; other site 1435356008687 Zn2+ binding site [ion binding]; other site 1435356008688 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1435356008689 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 1435356008690 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1435356008691 active site 1435356008692 catalytic residues [active] 1435356008693 metal binding site [ion binding]; metal-binding site 1435356008694 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1435356008695 Coenzyme A binding pocket [chemical binding]; other site 1435356008696 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1435356008697 putative catalytic site [active] 1435356008698 putative phosphate binding site [ion binding]; other site 1435356008699 active site 1435356008700 metal binding site A [ion binding]; metal-binding site 1435356008701 DNA binding site [nucleotide binding] 1435356008702 putative AP binding site [nucleotide binding]; other site 1435356008703 putative metal binding site B [ion binding]; other site 1435356008704 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1435356008705 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1435356008706 dimer interface [polypeptide binding]; other site 1435356008707 substrate binding site [chemical binding]; other site 1435356008708 ATP binding site [chemical binding]; other site 1435356008709 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1435356008710 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 1435356008711 PA/protease or protease-like domain interface [polypeptide binding]; other site 1435356008712 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 1435356008713 Peptidase family M28; Region: Peptidase_M28; pfam04389 1435356008714 active site 1435356008715 metal binding site [ion binding]; metal-binding site 1435356008716 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1435356008717 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1435356008718 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1435356008719 Walker A/P-loop; other site 1435356008720 ATP binding site [chemical binding]; other site 1435356008721 Q-loop/lid; other site 1435356008722 ABC transporter signature motif; other site 1435356008723 Walker B; other site 1435356008724 D-loop; other site 1435356008725 H-loop/switch region; other site 1435356008726 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1435356008727 ThiS interaction site; other site 1435356008728 putative active site [active] 1435356008729 tetramer interface [polypeptide binding]; other site 1435356008730 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1435356008731 thiS-thiF/thiG interaction site; other site 1435356008732 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1435356008733 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1435356008734 thiamine phosphate binding site [chemical binding]; other site 1435356008735 active site 1435356008736 pyrophosphate binding site [ion binding]; other site 1435356008737 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1435356008738 nudix motif; other site 1435356008739 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1435356008740 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1435356008741 substrate binding pocket [chemical binding]; other site 1435356008742 membrane-bound complex binding site; other site 1435356008743 hinge residues; other site 1435356008744 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1435356008745 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1435356008746 active site 1435356008747 ATP binding site [chemical binding]; other site 1435356008748 substrate binding site [chemical binding]; other site 1435356008749 activation loop (A-loop); other site 1435356008750 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1435356008751 propionate/acetate kinase; Provisional; Region: PRK12379 1435356008752 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1435356008753 phosphate acetyltransferase; Reviewed; Region: PRK05632 1435356008754 DRTGG domain; Region: DRTGG; pfam07085 1435356008755 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1435356008756 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 1435356008757 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1435356008758 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1435356008759 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1435356008760 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1435356008761 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 1435356008762 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1435356008763 active site 1435356008764 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1435356008765 non-prolyl cis peptide bond; other site 1435356008766 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1435356008767 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1435356008768 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1435356008769 Walker A/P-loop; other site 1435356008770 ATP binding site [chemical binding]; other site 1435356008771 Q-loop/lid; other site 1435356008772 ABC transporter signature motif; other site 1435356008773 Walker B; other site 1435356008774 D-loop; other site 1435356008775 H-loop/switch region; other site 1435356008776 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1435356008777 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1435356008778 Walker A/P-loop; other site 1435356008779 ATP binding site [chemical binding]; other site 1435356008780 Q-loop/lid; other site 1435356008781 ABC transporter signature motif; other site 1435356008782 Walker B; other site 1435356008783 D-loop; other site 1435356008784 H-loop/switch region; other site 1435356008785 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1435356008786 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1435356008787 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1435356008788 putative PBP binding loops; other site 1435356008789 dimer interface [polypeptide binding]; other site 1435356008790 ABC-ATPase subunit interface; other site 1435356008791 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1435356008792 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1435356008793 dimer interface [polypeptide binding]; other site 1435356008794 conserved gate region; other site 1435356008795 putative PBP binding loops; other site 1435356008796 ABC-ATPase subunit interface; other site 1435356008797 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1435356008798 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 1435356008799 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1435356008800 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1435356008801 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1435356008802 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1435356008803 Coenzyme A binding pocket [chemical binding]; other site 1435356008804 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 1435356008805 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1435356008806 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1435356008807 substrate binding pocket [chemical binding]; other site 1435356008808 membrane-bound complex binding site; other site 1435356008809 hinge residues; other site 1435356008810 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1435356008811 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1435356008812 Walker A/P-loop; other site 1435356008813 ATP binding site [chemical binding]; other site 1435356008814 Q-loop/lid; other site 1435356008815 ABC transporter signature motif; other site 1435356008816 Walker B; other site 1435356008817 D-loop; other site 1435356008818 H-loop/switch region; other site 1435356008819 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1435356008820 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1435356008821 dimer interface [polypeptide binding]; other site 1435356008822 conserved gate region; other site 1435356008823 putative PBP binding loops; other site 1435356008824 ABC-ATPase subunit interface; other site 1435356008825 hypothetical protein; Provisional; Region: PRK10621 1435356008826 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1435356008827 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1435356008828 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1435356008829 homotrimer interface [polypeptide binding]; other site 1435356008830 Walker A motif; other site 1435356008831 GTP binding site [chemical binding]; other site 1435356008832 Walker B motif; other site 1435356008833 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1435356008834 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1435356008835 Walker A/P-loop; other site 1435356008836 ATP binding site [chemical binding]; other site 1435356008837 Q-loop/lid; other site 1435356008838 ABC transporter signature motif; other site 1435356008839 Walker B; other site 1435356008840 D-loop; other site 1435356008841 H-loop/switch region; other site 1435356008842 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1435356008843 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1435356008844 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1435356008845 dimer interface [polypeptide binding]; other site 1435356008846 putative PBP binding regions; other site 1435356008847 ABC-ATPase subunit interface; other site 1435356008848 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 1435356008849 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1435356008850 putative binding site residues; other site 1435356008851 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 1435356008852 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1435356008853 homodimer interface [polypeptide binding]; other site 1435356008854 substrate-cofactor binding pocket; other site 1435356008855 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1435356008856 catalytic residue [active] 1435356008857 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 1435356008858 active site residue [active] 1435356008859 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 1435356008860 ferredoxin-NADP+ reductase; Region: PLN02852 1435356008861 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1435356008862 Protein of unknown function (DUF456); Region: DUF456; pfam04306 1435356008863 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 1435356008864 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 1435356008865 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1435356008866 active site 1435356008867 dimer interface [polypeptide binding]; other site 1435356008868 effector binding site; other site 1435356008869 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1435356008870 TSCPD domain; Region: TSCPD; pfam12637 1435356008871 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1435356008872 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1435356008873 active site 1435356008874 SnoaL-like domain; Region: SnoaL_2; pfam12680 1435356008875 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1435356008876 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1435356008877 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1435356008878 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1435356008879 DNA-binding site [nucleotide binding]; DNA binding site 1435356008880 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1435356008881 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1435356008882 homodimer interface [polypeptide binding]; other site 1435356008883 catalytic residue [active] 1435356008884 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 1435356008885 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1435356008886 putative active site [active] 1435356008887 putative metal binding site [ion binding]; other site 1435356008888 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1435356008889 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1435356008890 GDP-binding site [chemical binding]; other site 1435356008891 ACT binding site; other site 1435356008892 IMP binding site; other site 1435356008893 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1435356008894 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1435356008895 putative metal binding site [ion binding]; other site 1435356008896 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1435356008897 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1435356008898 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 1435356008899 glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047 1435356008900 putative ADP-binding pocket [chemical binding]; other site 1435356008901 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1435356008902 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1435356008903 active site 1435356008904 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1435356008905 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1435356008906 H-loop/switch region; other site 1435356008907 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 1435356008908 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1435356008909 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1435356008910 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1435356008911 Walker A/P-loop; other site 1435356008912 ATP binding site [chemical binding]; other site 1435356008913 Q-loop/lid; other site 1435356008914 ABC transporter signature motif; other site 1435356008915 Walker B; other site 1435356008916 D-loop; other site 1435356008917 H-loop/switch region; other site 1435356008918 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1435356008919 ABC-ATPase subunit interface; other site 1435356008920 dimer interface [polypeptide binding]; other site 1435356008921 putative PBP binding regions; other site 1435356008922 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1435356008923 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1435356008924 dimer interface [polypeptide binding]; other site 1435356008925 putative PBP binding regions; other site 1435356008926 ABC-ATPase subunit interface; other site 1435356008927 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1435356008928 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1435356008929 intersubunit interface [polypeptide binding]; other site 1435356008930 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1435356008931 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1435356008932 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1435356008933 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 1435356008934 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 1435356008935 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1435356008936 substrate binding site [chemical binding]; other site 1435356008937 THF binding site; other site 1435356008938 zinc-binding site [ion binding]; other site 1435356008939 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1435356008940 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1435356008941 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1435356008942 oxidoreductase; Provisional; Region: PRK06128 1435356008943 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1435356008944 NAD binding site [chemical binding]; other site 1435356008945 metal binding site [ion binding]; metal-binding site 1435356008946 active site 1435356008947 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1435356008948 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1435356008949 NAD(P) binding site [chemical binding]; other site 1435356008950 active site 1435356008951 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1435356008952 S-adenosylmethionine binding site [chemical binding]; other site 1435356008953 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 1435356008954 active site 1435356008955 SAM binding site [chemical binding]; other site 1435356008956 homodimer interface [polypeptide binding]; other site 1435356008957 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 1435356008958 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1435356008959 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1435356008960 precorrin-3B synthase; Region: CobG; TIGR02435 1435356008961 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1435356008962 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 1435356008963 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1435356008964 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1435356008965 active site 1435356008966 SAM binding site [chemical binding]; other site 1435356008967 homodimer interface [polypeptide binding]; other site 1435356008968 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1435356008969 active site 1435356008970 SAM binding site [chemical binding]; other site 1435356008971 homodimer interface [polypeptide binding]; other site 1435356008972 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1435356008973 active site 1435356008974 SAM binding site [chemical binding]; other site 1435356008975 homodimer interface [polypeptide binding]; other site 1435356008976 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1435356008977 active site 1435356008978 putative homodimer interface [polypeptide binding]; other site 1435356008979 SAM binding site [chemical binding]; other site 1435356008980 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1435356008981 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1435356008982 S-adenosylmethionine binding site [chemical binding]; other site 1435356008983 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 1435356008984 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1435356008985 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 1435356008986 metal ion-dependent adhesion site (MIDAS); other site 1435356008987 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1435356008988 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1435356008989 homodimer interface [polypeptide binding]; other site 1435356008990 Walker A motif; other site 1435356008991 ATP binding site [chemical binding]; other site 1435356008992 hydroxycobalamin binding site [chemical binding]; other site 1435356008993 Walker B motif; other site 1435356008994 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1435356008995 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1435356008996 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1435356008997 catalytic triad [active] 1435356008998 hypothetical protein; Provisional; Region: PRK07908 1435356008999 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1435356009000 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1435356009001 homodimer interface [polypeptide binding]; other site 1435356009002 catalytic residue [active] 1435356009003 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1435356009004 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 1435356009005 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1435356009006 motif II; other site 1435356009007 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 1435356009008 cobyric acid synthase; Provisional; Region: PRK00784 1435356009009 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1435356009010 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1435356009011 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1435356009012 catalytic triad [active] 1435356009013 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 1435356009014 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1435356009015 catalytic core [active] 1435356009016 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1435356009017 Predicted membrane protein [Function unknown]; Region: COG4129 1435356009018 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1435356009019 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 1435356009020 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1435356009021 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1435356009022 active site 1435356009023 intersubunit interface [polypeptide binding]; other site 1435356009024 zinc binding site [ion binding]; other site 1435356009025 Na+ binding site [ion binding]; other site 1435356009026 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1435356009027 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1435356009028 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 1435356009029 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1435356009030 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1435356009031 short chain dehydrogenase; Provisional; Region: PRK08267 1435356009032 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1435356009033 NAD(P) binding site [chemical binding]; other site 1435356009034 active site 1435356009035 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 1435356009036 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1435356009037 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1435356009038 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1435356009039 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1435356009040 dimer interface [polypeptide binding]; other site 1435356009041 active site 1435356009042 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1435356009043 active site 1435356009044 LemA family; Region: LemA; cl00742 1435356009045 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1435356009046 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1435356009047 NAD(P) binding site [chemical binding]; other site 1435356009048 active site 1435356009049 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1435356009050 Clp amino terminal domain; Region: Clp_N; pfam02861 1435356009051 Clp amino terminal domain; Region: Clp_N; pfam02861 1435356009052 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1435356009053 Walker A motif; other site 1435356009054 ATP binding site [chemical binding]; other site 1435356009055 Walker B motif; other site 1435356009056 arginine finger; other site 1435356009057 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1435356009058 Walker A motif; other site 1435356009059 ATP binding site [chemical binding]; other site 1435356009060 Walker B motif; other site 1435356009061 arginine finger; other site 1435356009062 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1435356009063 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1435356009064 heme-binding site [chemical binding]; other site 1435356009065 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 1435356009066 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 1435356009067 FAD binding pocket [chemical binding]; other site 1435356009068 FAD binding motif [chemical binding]; other site 1435356009069 phosphate binding motif [ion binding]; other site 1435356009070 beta-alpha-beta structure motif; other site 1435356009071 NAD binding pocket [chemical binding]; other site 1435356009072 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1435356009073 acyl-CoA synthetase; Validated; Region: PRK06188 1435356009074 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1435356009075 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1435356009076 acyl-activating enzyme (AAE) consensus motif; other site 1435356009077 acyl-activating enzyme (AAE) consensus motif; other site 1435356009078 putative AMP binding site [chemical binding]; other site 1435356009079 putative active site [active] 1435356009080 putative CoA binding site [chemical binding]; other site 1435356009081 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1435356009082 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 1435356009083 FAD binding pocket [chemical binding]; other site 1435356009084 conserved FAD binding motif [chemical binding]; other site 1435356009085 phosphate binding motif [ion binding]; other site 1435356009086 beta-alpha-beta structure motif; other site 1435356009087 NAD binding pocket [chemical binding]; other site 1435356009088 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12845 1435356009089 Predicted oxidoreductase [General function prediction only]; Region: COG3573 1435356009090 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1435356009091 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1435356009092 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1435356009093 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1435356009094 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1435356009095 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1435356009096 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1435356009097 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1435356009098 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1435356009099 3-ketosteroid-delta-1-dehydrogenase; Provisional; Region: PRK12837 1435356009100 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1435356009101 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 1435356009102 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1435356009103 DNA binding residues [nucleotide binding] 1435356009104 putative dimer interface [polypeptide binding]; other site 1435356009105 chaperone protein DnaJ; Provisional; Region: PRK14279 1435356009106 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1435356009107 HSP70 interaction site [polypeptide binding]; other site 1435356009108 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1435356009109 Zn binding sites [ion binding]; other site 1435356009110 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1435356009111 dimer interface [polypeptide binding]; other site 1435356009112 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1435356009113 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1435356009114 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1435356009115 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1435356009116 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1435356009117 nucleotide binding site [chemical binding]; other site 1435356009118 NEF interaction site [polypeptide binding]; other site 1435356009119 SBD interface [polypeptide binding]; other site 1435356009120 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1435356009121 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1435356009122 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 1435356009123 DNA binding residues [nucleotide binding] 1435356009124 putative dimer interface [polypeptide binding]; other site 1435356009125 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1435356009126 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1435356009127 Dynamin family; Region: Dynamin_N; pfam00350 1435356009128 G1 box; other site 1435356009129 GTP/Mg2+ binding site [chemical binding]; other site 1435356009130 G2 box; other site 1435356009131 Switch I region; other site 1435356009132 G3 box; other site 1435356009133 Switch II region; other site 1435356009134 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1435356009135 G1 box; other site 1435356009136 GTP/Mg2+ binding site [chemical binding]; other site 1435356009137 G2 box; other site 1435356009138 Switch I region; other site 1435356009139 G3 box; other site 1435356009140 Switch II region; other site 1435356009141 G4 box; other site 1435356009142 G5 box; other site 1435356009143 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 1435356009144 nucleotide binding site [chemical binding]; other site 1435356009145 SBD interface [polypeptide binding]; other site 1435356009146 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1435356009147 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1435356009148 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1435356009149 DNA binding residues [nucleotide binding] 1435356009150 dimerization interface [polypeptide binding]; other site 1435356009151 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1435356009152 4Fe-4S binding domain; Region: Fer4; pfam00037 1435356009153 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 1435356009154 Cysteine-rich domain; Region: CCG; pfam02754 1435356009155 Cysteine-rich domain; Region: CCG; pfam02754 1435356009156 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1435356009157 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1435356009158 Predicted esterase [General function prediction only]; Region: COG0627 1435356009159 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 1435356009160 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1435356009161 Di-iron ligands [ion binding]; other site 1435356009162 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1435356009163 DNA-binding site [nucleotide binding]; DNA binding site 1435356009164 RNA-binding motif; other site 1435356009165 aminotransferase AlaT; Validated; Region: PRK09265 1435356009166 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1435356009167 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1435356009168 homodimer interface [polypeptide binding]; other site 1435356009169 catalytic residue [active] 1435356009170 YibE/F-like protein; Region: YibE_F; pfam07907 1435356009171 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1435356009172 nucleotide binding site [chemical binding]; other site 1435356009173 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1435356009174 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1435356009175 active site 1435356009176 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1435356009177 Chain length determinant protein; Region: Wzz; cl15801 1435356009178 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1435356009179 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1435356009180 Condensation domain; Region: Condensation; pfam00668 1435356009181 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1435356009182 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1435356009183 acyl-activating enzyme (AAE) consensus motif; other site 1435356009184 AMP binding site [chemical binding]; other site 1435356009185 Condensation domain; Region: Condensation; pfam00668 1435356009186 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1435356009187 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1435356009188 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1435356009189 acyl-activating enzyme (AAE) consensus motif; other site 1435356009190 AMP binding site [chemical binding]; other site 1435356009191 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1435356009192 Condensation domain; Region: Condensation; pfam00668 1435356009193 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1435356009194 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1435356009195 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1435356009196 acyl-activating enzyme (AAE) consensus motif; other site 1435356009197 AMP binding site [chemical binding]; other site 1435356009198 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1435356009199 Condensation domain; Region: Condensation; pfam00668 1435356009200 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1435356009201 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1435356009202 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1435356009203 acyl-activating enzyme (AAE) consensus motif; other site 1435356009204 AMP binding site [chemical binding]; other site 1435356009205 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1435356009206 Condensation domain; Region: Condensation; pfam00668 1435356009207 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1435356009208 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1435356009209 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1435356009210 acyl-activating enzyme (AAE) consensus motif; other site 1435356009211 AMP binding site [chemical binding]; other site 1435356009212 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1435356009213 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1435356009214 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1435356009215 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1435356009216 acyl-activating enzyme (AAE) consensus motif; other site 1435356009217 AMP binding site [chemical binding]; other site 1435356009218 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1435356009219 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 1435356009220 Winged helix-turn helix; Region: HTH_29; pfam13551 1435356009221 Homeodomain-like domain; Region: HTH_32; pfam13565 1435356009222 Integrase core domain; Region: rve; pfam00665 1435356009223 Integrase core domain; Region: rve_3; pfam13683 1435356009224 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1435356009225 GTP-binding protein; Provisional; Region: PTZ00258 1435356009226 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1435356009227 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 1435356009228 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1435356009229 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1435356009230 substrate binding site; other site 1435356009231 tetramer interface; other site 1435356009232 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1435356009233 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1435356009234 NAD binding site [chemical binding]; other site 1435356009235 substrate binding site [chemical binding]; other site 1435356009236 homodimer interface [polypeptide binding]; other site 1435356009237 active site 1435356009238 Predicted dinucleotide-utilizing enzyme [General function prediction only]; Region: COG1712 1435356009239 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1435356009240 Domain of unknown function DUF108; Region: DUF108; pfam01958 1435356009241 oxidoreductase; Provisional; Region: PRK06128 1435356009242 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1435356009243 NAD binding site [chemical binding]; other site 1435356009244 metal binding site [ion binding]; metal-binding site 1435356009245 active site 1435356009246 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1435356009247 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1435356009248 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1435356009249 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1435356009250 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1435356009251 motif II; other site 1435356009252 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1435356009253 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1435356009254 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1435356009255 active site 1435356009256 phosphorylation site [posttranslational modification] 1435356009257 intermolecular recognition site; other site 1435356009258 dimerization interface [polypeptide binding]; other site 1435356009259 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1435356009260 DNA binding site [nucleotide binding] 1435356009261 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1435356009262 HAMP domain; Region: HAMP; pfam00672 1435356009263 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1435356009264 dimer interface [polypeptide binding]; other site 1435356009265 phosphorylation site [posttranslational modification] 1435356009266 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1435356009267 ATP binding site [chemical binding]; other site 1435356009268 Mg2+ binding site [ion binding]; other site 1435356009269 G-X-G motif; other site 1435356009270 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1435356009271 putative hydrophobic ligand binding site [chemical binding]; other site 1435356009272 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1435356009273 putative hydrolase; Provisional; Region: PRK02113 1435356009274 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1435356009275 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1435356009276 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1435356009277 Bacterial transcriptional regulator; Region: IclR; pfam01614 1435356009278 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1435356009279 Cytochrome P450; Region: p450; cl12078 1435356009280 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1435356009281 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1435356009282 FMN-binding pocket [chemical binding]; other site 1435356009283 flavin binding motif; other site 1435356009284 phosphate binding motif [ion binding]; other site 1435356009285 beta-alpha-beta structure motif; other site 1435356009286 NAD binding pocket [chemical binding]; other site 1435356009287 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1435356009288 catalytic loop [active] 1435356009289 iron binding site [ion binding]; other site 1435356009290 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356009291 metabolite-proton symporter; Region: 2A0106; TIGR00883 1435356009292 putative substrate translocation pore; other site 1435356009293 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1435356009294 dimerization interface [polypeptide binding]; other site 1435356009295 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1435356009296 dimer interface [polypeptide binding]; other site 1435356009297 phosphorylation site [posttranslational modification] 1435356009298 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1435356009299 ATP binding site [chemical binding]; other site 1435356009300 Mg2+ binding site [ion binding]; other site 1435356009301 G-X-G motif; other site 1435356009302 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1435356009303 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1435356009304 active site 1435356009305 phosphorylation site [posttranslational modification] 1435356009306 intermolecular recognition site; other site 1435356009307 dimerization interface [polypeptide binding]; other site 1435356009308 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1435356009309 DNA binding site [nucleotide binding] 1435356009310 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 1435356009311 putative metal binding residues [ion binding]; other site 1435356009312 signature motif; other site 1435356009313 dimer interface [polypeptide binding]; other site 1435356009314 active site 1435356009315 polyP binding site; other site 1435356009316 substrate binding site [chemical binding]; other site 1435356009317 acceptor-phosphate pocket; other site 1435356009318 CotH protein; Region: CotH; pfam08757 1435356009319 enoyl-CoA hydratase; Provisional; Region: PRK06190 1435356009320 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1435356009321 substrate binding site [chemical binding]; other site 1435356009322 oxyanion hole (OAH) forming residues; other site 1435356009323 trimer interface [polypeptide binding]; other site 1435356009324 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1435356009325 CoenzymeA binding site [chemical binding]; other site 1435356009326 subunit interaction site [polypeptide binding]; other site 1435356009327 PHB binding site; other site 1435356009328 Predicted transcriptional regulators [Transcription]; Region: COG1733 1435356009329 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1435356009330 dimerization interface [polypeptide binding]; other site 1435356009331 putative DNA binding site [nucleotide binding]; other site 1435356009332 putative Zn2+ binding site [ion binding]; other site 1435356009333 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1435356009334 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 1435356009335 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1435356009336 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1435356009337 DNA binding residues [nucleotide binding] 1435356009338 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1435356009339 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1435356009340 DNA binding residues [nucleotide binding] 1435356009341 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1435356009342 K+ potassium transporter; Region: K_trans; cl15781 1435356009343 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1435356009344 CoenzymeA binding site [chemical binding]; other site 1435356009345 subunit interaction site [polypeptide binding]; other site 1435356009346 PHB binding site; other site 1435356009347 amino acid transporter; Region: 2A0306; TIGR00909 1435356009348 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1435356009349 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1435356009350 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1435356009351 putative DNA binding site [nucleotide binding]; other site 1435356009352 putative Zn2+ binding site [ion binding]; other site 1435356009353 AsnC family; Region: AsnC_trans_reg; pfam01037 1435356009354 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1435356009355 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 1435356009356 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 1435356009357 NAD binding site [chemical binding]; other site 1435356009358 Phe binding site; other site 1435356009359 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 1435356009360 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1435356009361 dimer interface [polypeptide binding]; other site 1435356009362 PYR/PP interface [polypeptide binding]; other site 1435356009363 TPP binding site [chemical binding]; other site 1435356009364 substrate binding site [chemical binding]; other site 1435356009365 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1435356009366 TPP-binding site [chemical binding]; other site 1435356009367 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 1435356009368 GAF domain; Region: GAF_2; pfam13185 1435356009369 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1435356009370 SPW repeat; Region: SPW; pfam03779 1435356009371 SPW repeat; Region: SPW; pfam03779 1435356009372 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 1435356009373 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 1435356009374 putative NAD(P) binding site [chemical binding]; other site 1435356009375 putative substrate binding site [chemical binding]; other site 1435356009376 catalytic Zn binding site [ion binding]; other site 1435356009377 structural Zn binding site [ion binding]; other site 1435356009378 Hemerythrin-like domain; Region: Hr-like; cd12108 1435356009379 Fe binding site [ion binding]; other site 1435356009380 Predicted membrane protein [Function unknown]; Region: COG2323 1435356009381 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1435356009382 dimanganese center [ion binding]; other site 1435356009383 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1435356009384 Predicted acyl esterases [General function prediction only]; Region: COG2936 1435356009385 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1435356009386 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1435356009387 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1435356009388 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1435356009389 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1435356009390 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1435356009391 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1435356009392 exosortase A system-associated hydrolase 2; Region: hydr2_PEP; TIGR03101 1435356009393 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1435356009394 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1435356009395 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1435356009396 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1435356009397 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1435356009398 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 1435356009399 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 1435356009400 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1435356009401 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 1435356009402 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1435356009403 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1435356009404 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1435356009405 homodimer interface [polypeptide binding]; other site 1435356009406 catalytic residue [active] 1435356009407 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1435356009408 PhoU domain; Region: PhoU; pfam01895 1435356009409 Rdx family; Region: Rdx; cl01407 1435356009410 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1435356009411 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1435356009412 CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427 1435356009413 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1435356009414 DXD motif; other site 1435356009415 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 1435356009416 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 1435356009417 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1435356009418 trimer interface [polypeptide binding]; other site 1435356009419 active site 1435356009420 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356009421 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1435356009422 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1435356009423 catalytic residue [active] 1435356009424 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1435356009425 catalytic residues [active] 1435356009426 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1435356009427 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1435356009428 peroxiredoxin; Region: AhpC; TIGR03137 1435356009429 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1435356009430 dimer interface [polypeptide binding]; other site 1435356009431 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1435356009432 catalytic triad [active] 1435356009433 peroxidatic and resolving cysteines [active] 1435356009434 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1435356009435 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 1435356009436 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1435356009437 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1435356009438 Zn binding site [ion binding]; other site 1435356009439 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1435356009440 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1435356009441 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1435356009442 Proline dehydrogenase; Region: Pro_dh; cl03282 1435356009443 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1435356009444 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1435356009445 NAD(P) binding site [chemical binding]; other site 1435356009446 active site 1435356009447 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1435356009448 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1435356009449 active site 1435356009450 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1435356009451 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1435356009452 acyl-activating enzyme (AAE) consensus motif; other site 1435356009453 AMP binding site [chemical binding]; other site 1435356009454 active site 1435356009455 CoA binding site [chemical binding]; other site 1435356009456 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1435356009457 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1435356009458 NAD(P) binding site [chemical binding]; other site 1435356009459 active site 1435356009460 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1435356009461 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1435356009462 dimer interface [polypeptide binding]; other site 1435356009463 active site 1435356009464 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356009465 D-galactonate transporter; Region: 2A0114; TIGR00893 1435356009466 putative substrate translocation pore; other site 1435356009467 mesaconyl-CoA isomerase; Region: mesacon_CoA_iso; TIGR04253 1435356009468 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1435356009469 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1435356009470 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1435356009471 active site 1435356009472 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1435356009473 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1435356009474 active site 1435356009475 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 1435356009476 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 1435356009477 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 1435356009478 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1435356009479 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1435356009480 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1435356009481 heme binding site [chemical binding]; other site 1435356009482 ferroxidase pore; other site 1435356009483 ferroxidase diiron center [ion binding]; other site 1435356009484 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1435356009485 Coenzyme A binding pocket [chemical binding]; other site 1435356009486 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1435356009487 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 1435356009488 active site 1435356009489 catalytic residues [active] 1435356009490 metal binding site [ion binding]; metal-binding site 1435356009491 DmpG-like communication domain; Region: DmpG_comm; pfam07836 1435356009492 acetaldehyde dehydrogenase; Validated; Region: PRK08300 1435356009493 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1435356009494 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 1435356009495 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1435356009496 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1435356009497 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1435356009498 Bacterial transcriptional regulator; Region: IclR; pfam01614 1435356009499 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 1435356009500 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1435356009501 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1435356009502 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1435356009503 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1435356009504 Bacterial transcriptional regulator; Region: IclR; pfam01614 1435356009505 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1435356009506 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1435356009507 putative active site [active] 1435356009508 putative catalytic site [active] 1435356009509 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1435356009510 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1435356009511 active site 1435356009512 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1435356009513 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1435356009514 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1435356009515 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1435356009516 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1435356009517 carboxyltransferase (CT) interaction site; other site 1435356009518 biotinylation site [posttranslational modification]; other site 1435356009519 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 1435356009520 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1435356009521 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1435356009522 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356009523 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356009524 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1435356009525 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 1435356009526 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1435356009527 CHASE3 domain; Region: CHASE3; pfam05227 1435356009528 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1435356009529 HAMP domain; Region: HAMP; pfam00672 1435356009530 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1435356009531 dimer interface [polypeptide binding]; other site 1435356009532 phosphorylation site [posttranslational modification] 1435356009533 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1435356009534 ATP binding site [chemical binding]; other site 1435356009535 Mg2+ binding site [ion binding]; other site 1435356009536 G-X-G motif; other site 1435356009537 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1435356009538 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1435356009539 active site 1435356009540 phosphorylation site [posttranslational modification] 1435356009541 intermolecular recognition site; other site 1435356009542 dimerization interface [polypeptide binding]; other site 1435356009543 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1435356009544 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1435356009545 NAD binding site [chemical binding]; other site 1435356009546 catalytic Zn binding site [ion binding]; other site 1435356009547 structural Zn binding site [ion binding]; other site 1435356009548 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1435356009549 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1435356009550 putative dimer interface [polypeptide binding]; other site 1435356009551 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 1435356009552 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1435356009553 DNA binding residues [nucleotide binding] 1435356009554 putative dimer interface [polypeptide binding]; other site 1435356009555 MoxR-like ATPases [General function prediction only]; Region: COG0714 1435356009556 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1435356009557 Walker A motif; other site 1435356009558 ATP binding site [chemical binding]; other site 1435356009559 Walker B motif; other site 1435356009560 arginine finger; other site 1435356009561 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 1435356009562 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1435356009563 metal ion-dependent adhesion site (MIDAS); other site 1435356009564 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1435356009565 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1435356009566 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1435356009567 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1435356009568 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1435356009569 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1435356009570 catalytic loop [active] 1435356009571 iron binding site [ion binding]; other site 1435356009572 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1435356009573 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1435356009574 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1435356009575 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1435356009576 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1435356009577 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1435356009578 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 1435356009579 putative hydrophobic ligand binding site [chemical binding]; other site 1435356009580 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1435356009581 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1435356009582 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1435356009583 substrate binding pocket [chemical binding]; other site 1435356009584 dimerization interface [polypeptide binding]; other site 1435356009585 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1435356009586 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1435356009587 ATP binding site [chemical binding]; other site 1435356009588 Mg2+ binding site [ion binding]; other site 1435356009589 G-X-G motif; other site 1435356009590 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1435356009591 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 1435356009592 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1435356009593 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1435356009594 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1435356009595 Walker A/P-loop; other site 1435356009596 ATP binding site [chemical binding]; other site 1435356009597 Q-loop/lid; other site 1435356009598 ABC transporter signature motif; other site 1435356009599 Walker B; other site 1435356009600 D-loop; other site 1435356009601 H-loop/switch region; other site 1435356009602 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1435356009603 dimer interface [polypeptide binding]; other site 1435356009604 conserved gate region; other site 1435356009605 putative PBP binding loops; other site 1435356009606 ABC-ATPase subunit interface; other site 1435356009607 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1435356009608 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1435356009609 glutaminase; Provisional; Region: PRK00971 1435356009610 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1435356009611 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 1435356009612 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 1435356009613 Hemerythrin-like domain; Region: Hr-like; cd12108 1435356009614 Fe binding site [ion binding]; other site 1435356009615 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1435356009616 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1435356009617 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1435356009618 dimerization interface [polypeptide binding]; other site 1435356009619 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1435356009620 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1435356009621 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1435356009622 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1435356009623 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1435356009624 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 1435356009625 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1435356009626 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1435356009627 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1435356009628 Bacterial transcriptional regulator; Region: IclR; pfam01614 1435356009629 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1435356009630 dimerization interface [polypeptide binding]; other site 1435356009631 putative DNA binding site [nucleotide binding]; other site 1435356009632 putative Zn2+ binding site [ion binding]; other site 1435356009633 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1435356009634 arsenical-resistance protein; Region: acr3; TIGR00832 1435356009635 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1435356009636 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1435356009637 active site 1435356009638 Protein of unknown function (DUF808); Region: DUF808; cl01002 1435356009639 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1435356009640 active site 1435356009641 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1435356009642 dimerization interface [polypeptide binding]; other site 1435356009643 putative DNA binding site [nucleotide binding]; other site 1435356009644 putative Zn2+ binding site [ion binding]; other site 1435356009645 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 1435356009646 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1435356009647 putative metal binding site [ion binding]; other site 1435356009648 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1435356009649 Walker B motif; other site 1435356009650 DNA binding loops [nucleotide binding] 1435356009651 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1435356009652 protein-splicing catalytic site; other site 1435356009653 thioester formation/cholesterol transfer; other site 1435356009654 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1435356009655 protein-splicing catalytic site; other site 1435356009656 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1435356009657 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1435356009658 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1435356009659 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1435356009660 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1435356009661 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1435356009662 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1435356009663 dimer interface [polypeptide binding]; other site 1435356009664 ssDNA binding site [nucleotide binding]; other site 1435356009665 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1435356009666 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1435356009667 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1435356009668 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1435356009669 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1435356009670 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 1435356009671 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1435356009672 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1435356009673 structural tetrad; other site 1435356009674 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1435356009675 Protein of unknown function (DUF461); Region: DUF461; cl01071 1435356009676 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1435356009677 active site 1435356009678 dimerization interface [polypeptide binding]; other site 1435356009679 na(+)/h(+) antiporter; Region: c_cpa1; TIGR00844 1435356009680 YrhK-like protein; Region: YrhK; pfam14145 1435356009681 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 1435356009682 Predicted integral membrane protein [Function unknown]; Region: COG5650 1435356009683 Predicted integral membrane protein [Function unknown]; Region: COG5650 1435356009684 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1435356009685 Transglycosylase; Region: Transgly; pfam00912 1435356009686 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1435356009687 Predicted transcriptional regulators [Transcription]; Region: COG1695 1435356009688 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1435356009689 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 1435356009690 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 1435356009691 short chain dehydrogenase; Provisional; Region: PRK08251 1435356009692 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1435356009693 NAD(P) binding site [chemical binding]; other site 1435356009694 active site 1435356009695 Phosphotransferase enzyme family; Region: APH; pfam01636 1435356009696 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1435356009697 putative active site [active] 1435356009698 putative substrate binding site [chemical binding]; other site 1435356009699 ATP binding site [chemical binding]; other site 1435356009700 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1435356009701 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1435356009702 active site 1435356009703 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356009704 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356009705 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1435356009706 Transglycosylase; Region: Transgly; pfam00912 1435356009707 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1435356009708 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1435356009709 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1435356009710 dimer interface [polypeptide binding]; other site 1435356009711 conserved gate region; other site 1435356009712 putative PBP binding loops; other site 1435356009713 ABC-ATPase subunit interface; other site 1435356009714 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1435356009715 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1435356009716 dimer interface [polypeptide binding]; other site 1435356009717 conserved gate region; other site 1435356009718 putative PBP binding loops; other site 1435356009719 ABC-ATPase subunit interface; other site 1435356009720 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1435356009721 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1435356009722 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1435356009723 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1435356009724 Walker A/P-loop; other site 1435356009725 ATP binding site [chemical binding]; other site 1435356009726 Q-loop/lid; other site 1435356009727 ABC transporter signature motif; other site 1435356009728 Walker B; other site 1435356009729 D-loop; other site 1435356009730 H-loop/switch region; other site 1435356009731 TOBE domain; Region: TOBE_2; pfam08402 1435356009732 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1435356009733 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1435356009734 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 1435356009735 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 1435356009736 putative hydrophobic ligand binding site [chemical binding]; other site 1435356009737 Gas vesicle protein; Region: Gas_vesicle; cl02954 1435356009738 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 1435356009739 Gas vesicle protein G; Region: GvpG; pfam05120 1435356009740 Gas vesicle synthesis protein GvpO; Region: GvpO; pfam05800 1435356009741 Gas vesicle protein; Region: Gas_vesicle; pfam00741 1435356009742 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 1435356009743 Gas vesicle protein; Region: Gas_vesicle; cl02954 1435356009744 Gas vesicle protein K; Region: GvpK; pfam05121 1435356009745 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1435356009746 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1435356009747 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1435356009748 active site 1435356009749 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1435356009750 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1435356009751 active site 1435356009752 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1435356009753 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356009754 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1435356009755 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1435356009756 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1435356009757 Secretory lipase; Region: LIP; pfam03583 1435356009758 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1435356009759 Lipase (class 2); Region: Lipase_2; pfam01674 1435356009760 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1435356009761 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1435356009762 Integrase core domain; Region: rve_3; cl15866 1435356009763 ERCC4 domain; Region: ERCC4; pfam02732 1435356009764 Lsr2; Region: Lsr2; pfam11774 1435356009765 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 1435356009766 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1435356009767 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1435356009768 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 1435356009769 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1435356009770 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1435356009771 Thioesterase domain; Region: Thioesterase; pfam00975 1435356009772 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 1435356009773 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 1435356009774 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1435356009775 metabolite-proton symporter; Region: 2A0106; TIGR00883 1435356009776 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1435356009777 S-adenosylmethionine binding site [chemical binding]; other site 1435356009778 Pirin-related protein [General function prediction only]; Region: COG1741 1435356009779 Pirin; Region: Pirin; pfam02678 1435356009780 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1435356009781 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1435356009782 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1435356009783 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1435356009784 S-adenosylmethionine binding site [chemical binding]; other site 1435356009785 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1435356009786 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1435356009787 hypothetical protein; Provisional; Region: PRK07945 1435356009788 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1435356009789 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1435356009790 active site 1435356009791 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1435356009792 putative active site [active] 1435356009793 short chain dehydrogenase; Provisional; Region: PRK08219 1435356009794 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1435356009795 NAD(P) binding site [chemical binding]; other site 1435356009796 active site 1435356009797 haloalkane dehalogenase; Provisional; Region: PRK00870 1435356009798 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 1435356009799 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1435356009800 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1435356009801 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1435356009802 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1435356009803 CsbD-like; Region: CsbD; cl17424 1435356009804 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1435356009805 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1435356009806 HIGH motif; other site 1435356009807 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1435356009808 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1435356009809 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1435356009810 active site 1435356009811 KMSKS motif; other site 1435356009812 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1435356009813 tRNA binding surface [nucleotide binding]; other site 1435356009814 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1435356009815 SdpI/YhfL protein family; Region: SdpI; pfam13630 1435356009816 Hemerythrin-like domain; Region: Hr-like; cd12108 1435356009817 Fe binding site [ion binding]; other site 1435356009818 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1435356009819 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1435356009820 DNA binding residues [nucleotide binding] 1435356009821 dimerization interface [polypeptide binding]; other site 1435356009822 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1435356009823 hypothetical protein; Validated; Region: PRK00228 1435356009824 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356009825 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1435356009826 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1435356009827 NAD(P) binding site [chemical binding]; other site 1435356009828 active site 1435356009829 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 1435356009830 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1435356009831 Walker A/P-loop; other site 1435356009832 ATP binding site [chemical binding]; other site 1435356009833 Q-loop/lid; other site 1435356009834 ABC transporter signature motif; other site 1435356009835 Walker B; other site 1435356009836 D-loop; other site 1435356009837 H-loop/switch region; other site 1435356009838 TOBE domain; Region: TOBE; pfam03459 1435356009839 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1435356009840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1435356009841 dimer interface [polypeptide binding]; other site 1435356009842 conserved gate region; other site 1435356009843 putative PBP binding loops; other site 1435356009844 ABC-ATPase subunit interface; other site 1435356009845 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1435356009846 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1435356009847 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1435356009848 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1435356009849 DNA binding residues [nucleotide binding] 1435356009850 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1435356009851 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1435356009852 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1435356009853 [4Fe-4S] binding site [ion binding]; other site 1435356009854 molybdopterin cofactor binding site; other site 1435356009855 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1435356009856 molybdopterin cofactor binding site; other site 1435356009857 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1435356009858 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1435356009859 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1435356009860 FAD binding pocket [chemical binding]; other site 1435356009861 FAD binding motif [chemical binding]; other site 1435356009862 catalytic residues [active] 1435356009863 NAD binding pocket [chemical binding]; other site 1435356009864 phosphate binding motif [ion binding]; other site 1435356009865 beta-alpha-beta structure motif; other site 1435356009866 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1435356009867 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1435356009868 active site 1435356009869 NTP binding site [chemical binding]; other site 1435356009870 metal binding triad [ion binding]; metal-binding site 1435356009871 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1435356009872 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1435356009873 Zn2+ binding site [ion binding]; other site 1435356009874 Mg2+ binding site [ion binding]; other site 1435356009875 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1435356009876 active site 1435356009877 Ap6A binding site [chemical binding]; other site 1435356009878 nudix motif; other site 1435356009879 metal binding site [ion binding]; metal-binding site 1435356009880 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1435356009881 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1435356009882 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 1435356009883 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1435356009884 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1435356009885 DNA binding residues [nucleotide binding] 1435356009886 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1435356009887 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 1435356009888 active site 1435356009889 FMN binding site [chemical binding]; other site 1435356009890 substrate binding site [chemical binding]; other site 1435356009891 putative catalytic residue [active] 1435356009892 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1435356009893 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1435356009894 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1435356009895 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1435356009896 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1435356009897 catalytic residues [active] 1435356009898 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1435356009899 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1435356009900 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1435356009901 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1435356009902 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1435356009903 active site 1435356009904 metal binding site [ion binding]; metal-binding site 1435356009905 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1435356009906 ParB-like nuclease domain; Region: ParBc; pfam02195 1435356009907 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1435356009908 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1435356009909 P-loop; other site 1435356009910 Magnesium ion binding site [ion binding]; other site 1435356009911 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1435356009912 Magnesium ion binding site [ion binding]; other site 1435356009913 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1435356009914 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 1435356009915 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1435356009916 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1435356009917 G-X-X-G motif; other site 1435356009918 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1435356009919 RxxxH motif; other site 1435356009920 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 1435356009921 ribonuclease P; Reviewed; Region: rnpA; PRK03459 1435356009922 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1435356009923 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 1435356009924 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1435356009925 Walker A motif; other site 1435356009926 ATP binding site [chemical binding]; other site 1435356009927 Walker B motif; other site 1435356009928 arginine finger; other site 1435356009929 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1435356009930 DnaA box-binding interface [nucleotide binding]; other site 1435356009931 DNA polymerase III subunit beta; Validated; Region: PRK07761 1435356009932 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1435356009933 putative DNA binding surface [nucleotide binding]; other site 1435356009934 dimer interface [polypeptide binding]; other site 1435356009935 beta-clamp/clamp loader binding surface; other site 1435356009936 beta-clamp/translesion DNA polymerase binding surface; other site 1435356009937 recombination protein F; Reviewed; Region: recF; PRK00064 1435356009938 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1435356009939 Walker A/P-loop; other site 1435356009940 ATP binding site [chemical binding]; other site 1435356009941 Q-loop/lid; other site 1435356009942 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1435356009943 ABC transporter signature motif; other site 1435356009944 Walker B; other site 1435356009945 D-loop; other site 1435356009946 H-loop/switch region; other site 1435356009947 Protein of unknown function (DUF721); Region: DUF721; cl02324 1435356009948 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1435356009949 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1435356009950 ATP binding site [chemical binding]; other site 1435356009951 Mg2+ binding site [ion binding]; other site 1435356009952 G-X-G motif; other site 1435356009953 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1435356009954 anchoring element; other site 1435356009955 dimer interface [polypeptide binding]; other site 1435356009956 ATP binding site [chemical binding]; other site 1435356009957 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1435356009958 active site 1435356009959 putative metal-binding site [ion binding]; other site 1435356009960 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1435356009961 HAMP domain; Region: HAMP; pfam00672 1435356009962 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1435356009963 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1435356009964 ATP binding site [chemical binding]; other site 1435356009965 Mg2+ binding site [ion binding]; other site 1435356009966 G-X-G motif; other site 1435356009967 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 1435356009968 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1435356009969 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1435356009970 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 1435356009971 G1 box; other site 1435356009972 GTP/Mg2+ binding site [chemical binding]; other site 1435356009973 G2 box; other site 1435356009974 Switch I region; other site 1435356009975 G3 box; other site 1435356009976 Switch II region; other site 1435356009977 G4 box; other site 1435356009978 G5 box; other site 1435356009979 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1435356009980 DNA gyrase subunit A; Validated; Region: PRK05560 1435356009981 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1435356009982 CAP-like domain; other site 1435356009983 active site 1435356009984 primary dimer interface [polypeptide binding]; other site 1435356009985 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1435356009986 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1435356009987 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1435356009988 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1435356009989 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1435356009990 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1435356009991 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1435356009992 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356009993 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356009994 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1435356009995 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1435356009996 Walker A/P-loop; other site 1435356009997 ATP binding site [chemical binding]; other site 1435356009998 Q-loop/lid; other site 1435356009999 ABC transporter signature motif; other site 1435356010000 Walker B; other site 1435356010001 D-loop; other site 1435356010002 H-loop/switch region; other site 1435356010003 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1435356010004 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1435356010005 FtsX-like permease family; Region: FtsX; pfam02687 1435356010006 Protein of unknown function (DUF461); Region: DUF461; pfam04314 1435356010007 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1435356010008 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 1435356010009 active site 1435356010010 diiron metal binding site [ion binding]; other site 1435356010011 Secretory lipase; Region: LIP; pfam03583 1435356010012 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1435356010013 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1435356010014 active site 1435356010015 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1435356010016 active site 1435356010017 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1435356010018 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1435356010019 putative septation inhibitor protein; Reviewed; Region: PRK00159 1435356010020 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1435356010021 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1435356010022 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1435356010023 glutamine binding [chemical binding]; other site 1435356010024 catalytic triad [active] 1435356010025 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1435356010026 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1435356010027 active site 1435356010028 ATP binding site [chemical binding]; other site 1435356010029 substrate binding site [chemical binding]; other site 1435356010030 activation loop (A-loop); other site 1435356010031 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1435356010032 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1435356010033 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1435356010034 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1435356010035 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1435356010036 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1435356010037 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1435356010038 active site 1435356010039 ATP binding site [chemical binding]; other site 1435356010040 substrate binding site [chemical binding]; other site 1435356010041 activation loop (A-loop); other site 1435356010042 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1435356010043 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1435356010044 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1435356010045 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1435356010046 active site 1435356010047 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1435356010048 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1435356010049 phosphopeptide binding site; other site 1435356010050 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 1435356010051 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1435356010052 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1435356010053 phosphopeptide binding site; other site 1435356010054 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1435356010055 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356010056 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1435356010057 putative substrate translocation pore; other site 1435356010058 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1435356010059 RibD C-terminal domain; Region: RibD_C; cl17279 1435356010060 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1435356010061 putative homodimer interface [polypeptide binding]; other site 1435356010062 putative homotetramer interface [polypeptide binding]; other site 1435356010063 putative allosteric switch controlling residues; other site 1435356010064 putative metal binding site [ion binding]; other site 1435356010065 putative homodimer-homodimer interface [polypeptide binding]; other site 1435356010066 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1435356010067 metal-binding site [ion binding] 1435356010068 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1435356010069 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1435356010070 metal-binding site [ion binding] 1435356010071 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1435356010072 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1435356010073 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1435356010074 NADP binding site [chemical binding]; other site 1435356010075 dimer interface [polypeptide binding]; other site 1435356010076 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1435356010077 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 1435356010078 tetramer interface [polypeptide binding]; other site 1435356010079 heme binding pocket [chemical binding]; other site 1435356010080 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1435356010081 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1435356010082 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1435356010083 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1435356010084 Walker A/P-loop; other site 1435356010085 ATP binding site [chemical binding]; other site 1435356010086 Q-loop/lid; other site 1435356010087 ABC transporter signature motif; other site 1435356010088 Walker B; other site 1435356010089 D-loop; other site 1435356010090 H-loop/switch region; other site 1435356010091 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1435356010092 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1435356010093 dimer interface [polypeptide binding]; other site 1435356010094 conserved gate region; other site 1435356010095 putative PBP binding loops; other site 1435356010096 ABC-ATPase subunit interface; other site 1435356010097 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1435356010098 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1435356010099 active site 1435356010100 non-prolyl cis peptide bond; other site 1435356010101 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1435356010102 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1435356010103 substrate binding pocket [chemical binding]; other site 1435356010104 membrane-bound complex binding site; other site 1435356010105 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1435356010106 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1435356010107 Clp amino terminal domain; Region: Clp_N; pfam02861 1435356010108 Clp amino terminal domain; Region: Clp_N; pfam02861 1435356010109 E-class dimer interface [polypeptide binding]; other site 1435356010110 Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080 1435356010111 P-class dimer interface [polypeptide binding]; other site 1435356010112 active site 1435356010113 Cu2+ binding site [ion binding]; other site 1435356010114 Zn2+ binding site [ion binding]; other site 1435356010115 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1435356010116 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 1435356010117 heme binding pocket [chemical binding]; other site 1435356010118 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1435356010119 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 1435356010120 hypothetical protein; Provisional; Region: PRK07236 1435356010121 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1435356010122 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1435356010123 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356010124 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1435356010125 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1435356010126 active site 1435356010127 dimer interface [polypeptide binding]; other site 1435356010128 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1435356010129 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1435356010130 active site 1435356010131 FMN binding site [chemical binding]; other site 1435356010132 substrate binding site [chemical binding]; other site 1435356010133 3Fe-4S cluster binding site [ion binding]; other site 1435356010134 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1435356010135 domain interface; other site 1435356010136 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1435356010137 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1435356010138 DoxX; Region: DoxX; pfam07681 1435356010139 Cutinase; Region: Cutinase; pfam01083 1435356010140 classical (c) SDRs; Region: SDR_c; cd05233 1435356010141 NAD(P) binding site [chemical binding]; other site 1435356010142 active site 1435356010143 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 1435356010144 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1435356010145 SnoaL-like domain; Region: SnoaL_3; pfam13474 1435356010146 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1435356010147 catalytic core [active] 1435356010148 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 1435356010149 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1435356010150 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1435356010151 dimer interface [polypeptide binding]; other site 1435356010152 putative anticodon binding site; other site 1435356010153 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1435356010154 motif 1; other site 1435356010155 dimer interface [polypeptide binding]; other site 1435356010156 active site 1435356010157 motif 2; other site 1435356010158 motif 3; other site 1435356010159 MMPL family; Region: MMPL; pfam03176 1435356010160 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1435356010161 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1435356010162 S-adenosylmethionine binding site [chemical binding]; other site 1435356010163 Anti-sigma-K factor rskA; Region: RskA; pfam10099 1435356010164 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 1435356010165 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1435356010166 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1435356010167 DNA binding residues [nucleotide binding] 1435356010168 Protein of unknown function (DUF1365); Region: DUF1365; cl17838 1435356010169 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1435356010170 Fasciclin domain; Region: Fasciclin; pfam02469 1435356010171 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 1435356010172 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1435356010173 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 1435356010174 putative NAD(P) binding site [chemical binding]; other site 1435356010175 putative active site [active] 1435356010176 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 1435356010177 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 1435356010178 putative hydrophobic ligand binding site [chemical binding]; other site 1435356010179 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1435356010180 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1435356010181 putative NAD(P) binding site [chemical binding]; other site 1435356010182 putative active site [active] 1435356010183 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1435356010184 DNA photolyase; Region: DNA_photolyase; pfam00875 1435356010185 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1435356010186 RNA binding surface [nucleotide binding]; other site 1435356010187 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1435356010188 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1435356010189 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1435356010190 acyl-activating enzyme (AAE) consensus motif; other site 1435356010191 putative AMP binding site [chemical binding]; other site 1435356010192 putative active site [active] 1435356010193 putative CoA binding site [chemical binding]; other site 1435356010194 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1435356010195 dimerization interface [polypeptide binding]; other site 1435356010196 putative DNA binding site [nucleotide binding]; other site 1435356010197 putative Zn2+ binding site [ion binding]; other site 1435356010198 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 1435356010199 putative hydrophobic ligand binding site [chemical binding]; other site 1435356010200 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1435356010201 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 1435356010202 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 1435356010203 NAD(P) binding site [chemical binding]; other site 1435356010204 catalytic residues [active] 1435356010205 Putative esterase; Region: Esterase; pfam00756 1435356010206 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1435356010207 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356010208 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1435356010209 putative substrate translocation pore; other site 1435356010210 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356010211 phytoene desaturase; Region: crtI_fam; TIGR02734 1435356010212 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1435356010213 active site lid residues [active] 1435356010214 substrate binding pocket [chemical binding]; other site 1435356010215 catalytic residues [active] 1435356010216 substrate-Mg2+ binding site; other site 1435356010217 aspartate-rich region 1; other site 1435356010218 aspartate-rich region 2; other site 1435356010219 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1435356010220 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 1435356010221 active site 1435356010222 metal binding site [ion binding]; metal-binding site 1435356010223 nudix motif; other site 1435356010224 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 1435356010225 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1435356010226 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1435356010227 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1435356010228 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1435356010229 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 1435356010230 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1435356010231 carboxyltransferase (CT) interaction site; other site 1435356010232 biotinylation site [posttranslational modification]; other site 1435356010233 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1435356010234 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1435356010235 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1435356010236 Fe-S cluster binding site [ion binding]; other site 1435356010237 active site 1435356010238 Copper resistance protein D; Region: CopD; cl00563 1435356010239 CopC domain; Region: CopC; pfam04234 1435356010240 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 1435356010241 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 1435356010242 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1435356010243 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1435356010244 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1435356010245 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 1435356010246 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1435356010247 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1435356010248 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1435356010249 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1435356010250 Methylamine dehydrogenase, L chain; Region: Me-amine-dh_L; cl03812 1435356010251 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1435356010252 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1435356010253 Methylamine utilisation protein MauE; Region: MauE; pfam07291 1435356010254 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1435356010255 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1435356010256 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1435356010257 Bacterial transcriptional regulator; Region: IclR; pfam01614 1435356010258 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1435356010259 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1435356010260 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1435356010261 NAD(P) binding site [chemical binding]; other site 1435356010262 active site 1435356010263 H+ Antiporter protein; Region: 2A0121; TIGR00900 1435356010264 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1435356010265 MarR family; Region: MarR; pfam01047 1435356010266 Predicted membrane protein [Function unknown]; Region: COG2119 1435356010267 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1435356010268 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1435356010269 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1435356010270 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1435356010271 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1435356010272 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1435356010273 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1435356010274 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1435356010275 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1435356010276 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1435356010277 active site residue [active] 1435356010278 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 1435356010279 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1435356010280 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 1435356010281 putative active site [active] 1435356010282 catalytic site [active] 1435356010283 putative metal binding site [ion binding]; other site 1435356010284 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1435356010285 Ferritin-like domain; Region: Ferritin; pfam00210 1435356010286 ferroxidase diiron center [ion binding]; other site 1435356010287 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1435356010288 CAAX protease self-immunity; Region: Abi; pfam02517 1435356010289 metabolite-proton symporter; Region: 2A0106; TIGR00883 1435356010290 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356010291 putative substrate translocation pore; other site 1435356010292 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 1435356010293 prephenate dehydratase; Provisional; Region: PRK11898 1435356010294 Prephenate dehydratase; Region: PDT; pfam00800 1435356010295 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1435356010296 putative L-Phe binding site [chemical binding]; other site 1435356010297 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1435356010298 catalytic core [active] 1435356010299 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356010300 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356010301 RibD C-terminal domain; Region: RibD_C; cl17279 1435356010302 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356010303 enoyl-CoA hydratase; Provisional; Region: PRK06688 1435356010304 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1435356010305 substrate binding site [chemical binding]; other site 1435356010306 oxyanion hole (OAH) forming residues; other site 1435356010307 trimer interface [polypeptide binding]; other site 1435356010308 acetyl-CoA acetyltransferase; Provisional; Region: PRK06504 1435356010309 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1435356010310 dimer interface [polypeptide binding]; other site 1435356010311 active site 1435356010312 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 1435356010313 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 1435356010314 NAD binding site [chemical binding]; other site 1435356010315 homodimer interface [polypeptide binding]; other site 1435356010316 homotetramer interface [polypeptide binding]; other site 1435356010317 active site 1435356010318 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356010319 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356010320 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1435356010321 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1435356010322 FMN binding site [chemical binding]; other site 1435356010323 substrate binding site [chemical binding]; other site 1435356010324 putative catalytic residue [active] 1435356010325 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1435356010326 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1435356010327 active site 1435356010328 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1435356010329 active site 1435356010330 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1435356010331 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1435356010332 NAD(P) binding site [chemical binding]; other site 1435356010333 active site 1435356010334 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 1435356010335 nudix motif; other site 1435356010336 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1435356010337 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 1435356010338 Septum formation; Region: Septum_form; pfam13845 1435356010339 Septum formation; Region: Septum_form; pfam13845 1435356010340 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1435356010341 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1435356010342 seryl-tRNA synthetase; Provisional; Region: PRK05431 1435356010343 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1435356010344 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1435356010345 dimer interface [polypeptide binding]; other site 1435356010346 active site 1435356010347 motif 1; other site 1435356010348 motif 2; other site 1435356010349 motif 3; other site 1435356010350 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1435356010351 CoenzymeA binding site [chemical binding]; other site 1435356010352 subunit interaction site [polypeptide binding]; other site 1435356010353 PHB binding site; other site 1435356010354 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356010355 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1435356010356 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1435356010357 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1435356010358 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1435356010359 iron-sulfur cluster [ion binding]; other site 1435356010360 [2Fe-2S] cluster binding site [ion binding]; other site 1435356010361 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Provisional; Region: PRK13585 1435356010362 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1435356010363 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1435356010364 putative acyl-acceptor binding pocket; other site 1435356010365 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1435356010366 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1435356010367 active site 1435356010368 motif I; other site 1435356010369 motif II; other site 1435356010370 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1435356010371 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1435356010372 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1435356010373 amidase catalytic site [active] 1435356010374 Zn binding residues [ion binding]; other site 1435356010375 substrate binding site [chemical binding]; other site 1435356010376 LGFP repeat; Region: LGFP; pfam08310 1435356010377 Stage II sporulation protein; Region: SpoIID; pfam08486 1435356010378 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 1435356010379 LGFP repeat; Region: LGFP; pfam08310 1435356010380 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1435356010381 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1435356010382 DNA binding residues [nucleotide binding] 1435356010383 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1435356010384 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1435356010385 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1435356010386 UDP-galactopyranose mutase; Region: GLF; pfam03275 1435356010387 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1435356010388 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1435356010389 active site 1435356010390 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 1435356010391 Putative esterase; Region: Esterase; pfam00756 1435356010392 Putative esterase; Region: Esterase; pfam00756 1435356010393 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1435356010394 LGFP repeat; Region: LGFP; pfam08310 1435356010395 LGFP repeat; Region: LGFP; pfam08310 1435356010396 LGFP repeat; Region: LGFP; pfam08310 1435356010397 Cutinase; Region: Cutinase; pfam01083 1435356010398 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 1435356010399 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1435356010400 acyl-activating enzyme (AAE) consensus motif; other site 1435356010401 active site 1435356010402 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1435356010403 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1435356010404 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1435356010405 active site 1435356010406 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1435356010407 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1435356010408 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1435356010409 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1435356010410 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1435356010411 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1435356010412 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835 1435356010413 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1435356010414 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1435356010415 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1435356010416 FAD binding domain; Region: FAD_binding_4; pfam01565 1435356010417 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1435356010418 DoxX-like family; Region: DoxX_2; pfam13564 1435356010419 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 1435356010420 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 1435356010421 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1435356010422 classical (c) SDRs; Region: SDR_c; cd05233 1435356010423 NAD(P) binding site [chemical binding]; other site 1435356010424 active site 1435356010425 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1435356010426 FAD binding domain; Region: FAD_binding_4; pfam01565 1435356010427 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1435356010428 Predicted membrane protein [Function unknown]; Region: COG2246 1435356010429 GtrA-like protein; Region: GtrA; pfam04138 1435356010430 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1435356010431 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1435356010432 putative active site [active] 1435356010433 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 1435356010434 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1435356010435 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1435356010436 substrate binding site; other site 1435356010437 tetramer interface; other site 1435356010438 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1435356010439 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1435356010440 NAD binding site [chemical binding]; other site 1435356010441 substrate binding site [chemical binding]; other site 1435356010442 homodimer interface [polypeptide binding]; other site 1435356010443 active site 1435356010444 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1435356010445 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1435356010446 active site 1435356010447 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1435356010448 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1435356010449 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1435356010450 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1435356010451 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1435356010452 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1435356010453 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1435356010454 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1435356010455 Fic family protein [Function unknown]; Region: COG3177 1435356010456 Fic/DOC family; Region: Fic; pfam02661 1435356010457 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 1435356010458 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 1435356010459 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1435356010460 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1435356010461 ATP binding site [chemical binding]; other site 1435356010462 putative Mg++ binding site [ion binding]; other site 1435356010463 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1435356010464 nucleotide binding region [chemical binding]; other site 1435356010465 ATP-binding site [chemical binding]; other site 1435356010466 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1435356010467 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1435356010468 putative metal binding site [ion binding]; other site 1435356010469 PAS fold; Region: PAS_4; pfam08448 1435356010470 GAF domain; Region: GAF_3; pfam13492 1435356010471 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1435356010472 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1435356010473 dimer interface [polypeptide binding]; other site 1435356010474 phosphorylation site [posttranslational modification] 1435356010475 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1435356010476 ATP binding site [chemical binding]; other site 1435356010477 Mg2+ binding site [ion binding]; other site 1435356010478 G-X-G motif; other site 1435356010479 Response regulator receiver domain; Region: Response_reg; pfam00072 1435356010480 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1435356010481 active site 1435356010482 phosphorylation site [posttranslational modification] 1435356010483 intermolecular recognition site; other site 1435356010484 dimerization interface [polypeptide binding]; other site 1435356010485 ANTAR domain; Region: ANTAR; pfam03861 1435356010486 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1435356010487 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1435356010488 acyl-activating enzyme (AAE) consensus motif; other site 1435356010489 putative AMP binding site [chemical binding]; other site 1435356010490 putative active site [active] 1435356010491 putative CoA binding site [chemical binding]; other site 1435356010492 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1435356010493 [4Fe-4S] binding site [ion binding]; other site 1435356010494 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1435356010495 molybdopterin cofactor binding site; other site 1435356010496 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1435356010497 molybdopterin cofactor binding site; other site 1435356010498 methyl coenzyme M reductase system, component A2; Region: met_CoM_red_A2; TIGR03269 1435356010499 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1435356010500 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1435356010501 active site 1435356010502 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1435356010503 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1435356010504 Walker A/P-loop; other site 1435356010505 ATP binding site [chemical binding]; other site 1435356010506 Q-loop/lid; other site 1435356010507 ABC transporter signature motif; other site 1435356010508 Walker B; other site 1435356010509 D-loop; other site 1435356010510 H-loop/switch region; other site 1435356010511 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 1435356010512 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1435356010513 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1435356010514 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1435356010515 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1435356010516 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1435356010517 NAD(P) binding site [chemical binding]; other site 1435356010518 MarR family; Region: MarR_2; cl17246 1435356010519 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1435356010520 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1435356010521 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1435356010522 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1435356010523 SnoaL-like domain; Region: SnoaL_2; pfam12680 1435356010524 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1435356010525 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1435356010526 Putative esterase; Region: Esterase; pfam00756 1435356010527 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 1435356010528 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1435356010529 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 1435356010530 putative active site [active] 1435356010531 putative metal binding site [ion binding]; other site 1435356010532 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1435356010533 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1435356010534 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1435356010535 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1435356010536 homodimer interface [polypeptide binding]; other site 1435356010537 catalytic residue [active] 1435356010538 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1435356010539 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1435356010540 active site 1435356010541 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1435356010542 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1435356010543 active site 1435356010544 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 1435356010545 additional DNA contacts [nucleotide binding]; other site 1435356010546 active site 1435356010547 zinc binding site [ion binding]; other site 1435356010548 DNA intercalation site [nucleotide binding]; other site 1435356010549 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1435356010550 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1435356010551 cofactor binding site; other site 1435356010552 DNA binding site [nucleotide binding] 1435356010553 substrate interaction site [chemical binding]; other site 1435356010554 GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; Region: GIY-YIG_COG3680; cd10440 1435356010555 GIY-YIG motif/motif A; other site 1435356010556 putative active site [active] 1435356010557 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 1435356010558 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1435356010559 Amidase; Region: Amidase; cl11426 1435356010560 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 1435356010561 prephenate dehydrogenase; Validated; Region: PRK08507 1435356010562 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 1435356010563 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1435356010564 nucleoside/Zn binding site; other site 1435356010565 dimer interface [polypeptide binding]; other site 1435356010566 catalytic motif [active] 1435356010567 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1435356010568 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1435356010569 catalytic site [active] 1435356010570 oxidoreductase; Provisional; Region: PRK12743 1435356010571 classical (c) SDRs; Region: SDR_c; cd05233 1435356010572 NAD(P) binding site [chemical binding]; other site 1435356010573 active site 1435356010574 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1435356010575 active site 1435356010576 metal binding site [ion binding]; metal-binding site 1435356010577 homotetramer interface [polypeptide binding]; other site 1435356010578 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356010579 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356010580 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1435356010581 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356010582 putative substrate translocation pore; other site 1435356010583 YceI-like domain; Region: YceI; pfam04264 1435356010584 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1435356010585 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1435356010586 Predicted transcriptional regulator [Transcription]; Region: COG1959 1435356010587 Transcriptional regulator; Region: Rrf2; pfam02082 1435356010588 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1435356010589 MMPL family; Region: MMPL; pfam03176 1435356010590 MMPL family; Region: MMPL; pfam03176 1435356010591 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1435356010592 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1435356010593 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1435356010594 Walker A/P-loop; other site 1435356010595 ATP binding site [chemical binding]; other site 1435356010596 Q-loop/lid; other site 1435356010597 ABC transporter signature motif; other site 1435356010598 Walker B; other site 1435356010599 D-loop; other site 1435356010600 H-loop/switch region; other site 1435356010601 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1435356010602 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1435356010603 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1435356010604 Walker A/P-loop; other site 1435356010605 ATP binding site [chemical binding]; other site 1435356010606 Q-loop/lid; other site 1435356010607 ABC transporter signature motif; other site 1435356010608 Walker B; other site 1435356010609 D-loop; other site 1435356010610 H-loop/switch region; other site 1435356010611 MarR family; Region: MarR_2; pfam12802 1435356010612 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1435356010613 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1435356010614 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1435356010615 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1435356010616 dimerization interface [polypeptide binding]; other site 1435356010617 Lysine efflux permease [General function prediction only]; Region: COG1279 1435356010618 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1435356010619 Cation efflux family; Region: Cation_efflux; cl00316 1435356010620 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1435356010621 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1435356010622 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1435356010623 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1435356010624 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1435356010625 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1435356010626 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1435356010627 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356010628 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1435356010629 putative substrate translocation pore; other site 1435356010630 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1435356010631 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 1435356010632 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 1435356010633 RDD family; Region: RDD; pfam06271 1435356010634 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 1435356010635 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1435356010636 active site 1435356010637 HIGH motif; other site 1435356010638 nucleotide binding site [chemical binding]; other site 1435356010639 active site 1435356010640 KMSKS motif; other site 1435356010641 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1435356010642 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1435356010643 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1435356010644 dimerization interface [polypeptide binding]; other site 1435356010645 metabolite-proton symporter; Region: 2A0106; TIGR00883 1435356010646 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356010647 putative substrate translocation pore; other site 1435356010648 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1435356010649 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 1435356010650 NAD(P) binding site [chemical binding]; other site 1435356010651 active site 1435356010652 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356010653 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356010654 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1435356010655 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1435356010656 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1435356010657 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 1435356010658 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 1435356010659 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1435356010660 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1435356010661 homodimer interface [polypeptide binding]; other site 1435356010662 catalytic residue [active] 1435356010663 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1435356010664 minor groove reading motif; other site 1435356010665 helix-hairpin-helix signature motif; other site 1435356010666 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 1435356010667 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1435356010668 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1435356010669 substrate binding site [chemical binding]; other site 1435356010670 multimerization interface [polypeptide binding]; other site 1435356010671 ATP binding site [chemical binding]; other site 1435356010672 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1435356010673 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1435356010674 active site residue [active] 1435356010675 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1435356010676 active site residue [active] 1435356010677 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1435356010678 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1435356010679 DNA-binding site [nucleotide binding]; DNA binding site 1435356010680 FCD domain; Region: FCD; pfam07729 1435356010681 Predicted transcriptional regulators [Transcription]; Region: COG1695 1435356010682 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1435356010683 putative DNA binding site [nucleotide binding]; other site 1435356010684 putative Zn2+ binding site [ion binding]; other site 1435356010685 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1435356010686 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1435356010687 Walker A motif; other site 1435356010688 ATP binding site [chemical binding]; other site 1435356010689 Walker B motif; other site 1435356010690 arginine finger; other site 1435356010691 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1435356010692 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 1435356010693 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 1435356010694 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 1435356010695 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1435356010696 homotrimer interaction site [polypeptide binding]; other site 1435356010697 putative active site [active] 1435356010698 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 1435356010699 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1435356010700 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1435356010701 [2Fe-2S] cluster binding site [ion binding]; other site 1435356010702 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1435356010703 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1435356010704 NAD(P) binding site [chemical binding]; other site 1435356010705 catalytic residues [active] 1435356010706 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1435356010707 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1435356010708 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1435356010709 iron-sulfur cluster [ion binding]; other site 1435356010710 [2Fe-2S] cluster binding site [ion binding]; other site 1435356010711 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1435356010712 Domain of unknown function (DUF336); Region: DUF336; cl01249 1435356010713 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1435356010714 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1435356010715 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356010716 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1435356010717 putative substrate translocation pore; other site 1435356010718 DctM-like transporters; Region: DctM; pfam06808 1435356010719 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1435356010720 Histidine kinase; Region: HisKA_3; pfam07730 1435356010721 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1435356010722 ATP binding site [chemical binding]; other site 1435356010723 Mg2+ binding site [ion binding]; other site 1435356010724 G-X-G motif; other site 1435356010725 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1435356010726 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1435356010727 active site 1435356010728 phosphorylation site [posttranslational modification] 1435356010729 intermolecular recognition site; other site 1435356010730 dimerization interface [polypeptide binding]; other site 1435356010731 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1435356010732 DNA binding residues [nucleotide binding] 1435356010733 dimerization interface [polypeptide binding]; other site 1435356010734 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1435356010735 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1435356010736 DNA-binding site [nucleotide binding]; DNA binding site 1435356010737 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1435356010738 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 1435356010739 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1435356010740 dimer interface [polypeptide binding]; other site 1435356010741 active site 1435356010742 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1435356010743 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1435356010744 substrate binding site [chemical binding]; other site 1435356010745 oxyanion hole (OAH) forming residues; other site 1435356010746 trimer interface [polypeptide binding]; other site 1435356010747 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1435356010748 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1435356010749 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1435356010750 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1435356010751 S-adenosylmethionine binding site [chemical binding]; other site 1435356010752 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1435356010753 FAD binding domain; Region: FAD_binding_4; pfam01565 1435356010754 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 1435356010755 hydrophobic ligand binding site; other site 1435356010756 hypothetical protein; Validated; Region: PRK00153 1435356010757 recombination protein RecR; Reviewed; Region: recR; PRK00076 1435356010758 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1435356010759 RecR protein; Region: RecR; pfam02132 1435356010760 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1435356010761 putative active site [active] 1435356010762 putative metal-binding site [ion binding]; other site 1435356010763 tetramer interface [polypeptide binding]; other site 1435356010764 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356010765 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356010766 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1435356010767 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356010768 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1435356010769 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 1435356010770 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1435356010771 NAD(P) binding site [chemical binding]; other site 1435356010772 catalytic residues [active] 1435356010773 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1435356010774 DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990 1435356010775 DNA-binding site [nucleotide binding]; DNA binding site 1435356010776 FCD domain; Region: FCD; pfam07729 1435356010777 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 1435356010778 GXWXG protein; Region: GXWXG; pfam14231 1435356010779 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 1435356010780 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356010781 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356010782 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356010783 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356010784 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1435356010785 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1435356010786 FMN binding site [chemical binding]; other site 1435356010787 substrate binding site [chemical binding]; other site 1435356010788 putative catalytic residue [active] 1435356010789 enoyl-CoA hydratase; Provisional; Region: PRK06688 1435356010790 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1435356010791 substrate binding site [chemical binding]; other site 1435356010792 oxyanion hole (OAH) forming residues; other site 1435356010793 trimer interface [polypeptide binding]; other site 1435356010794 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 1435356010795 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1435356010796 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1435356010797 acyl-activating enzyme (AAE) consensus motif; other site 1435356010798 acyl-activating enzyme (AAE) consensus motif; other site 1435356010799 putative AMP binding site [chemical binding]; other site 1435356010800 putative active site [active] 1435356010801 putative CoA binding site [chemical binding]; other site 1435356010802 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1435356010803 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356010804 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1435356010805 DNA-binding interface [nucleotide binding]; DNA binding site 1435356010806 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1435356010807 active site residue [active] 1435356010808 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1435356010809 catalytic triad [active] 1435356010810 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1435356010811 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1435356010812 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1435356010813 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 1435356010814 EamA-like transporter family; Region: EamA; pfam00892 1435356010815 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1435356010816 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1435356010817 putative DNA binding site [nucleotide binding]; other site 1435356010818 putative Zn2+ binding site [ion binding]; other site 1435356010819 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 1435356010820 putative dimerization interface [polypeptide binding]; other site 1435356010821 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1435356010822 Short C-terminal domain; Region: SHOCT; pfam09851 1435356010823 2-isopropylmalate synthase; Validated; Region: PRK03739 1435356010824 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1435356010825 active site 1435356010826 catalytic residues [active] 1435356010827 metal binding site [ion binding]; metal-binding site 1435356010828 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1435356010829 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1435356010830 aspartate kinase; Reviewed; Region: PRK06635 1435356010831 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1435356010832 putative nucleotide binding site [chemical binding]; other site 1435356010833 putative catalytic residues [active] 1435356010834 putative Mg ion binding site [ion binding]; other site 1435356010835 putative aspartate binding site [chemical binding]; other site 1435356010836 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1435356010837 putative allosteric regulatory site; other site 1435356010838 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1435356010839 putative allosteric regulatory residue; other site 1435356010840 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1435356010841 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1435356010842 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356010843 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356010844 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1435356010845 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1435356010846 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1435356010847 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1435356010848 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1435356010849 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 1435356010850 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1435356010851 active site 1435356010852 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1435356010853 metal binding site 2 [ion binding]; metal-binding site 1435356010854 putative DNA binding helix; other site 1435356010855 metal binding site 1 [ion binding]; metal-binding site 1435356010856 dimer interface [polypeptide binding]; other site 1435356010857 structural Zn2+ binding site [ion binding]; other site 1435356010858 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1435356010859 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1435356010860 tetramer interface [polypeptide binding]; other site 1435356010861 heme binding pocket [chemical binding]; other site 1435356010862 NADPH binding site [chemical binding]; other site 1435356010863 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 1435356010864 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1435356010865 FAD binding domain; Region: FAD_binding_4; pfam01565 1435356010866 Cholesterol oxidase, substrate-binding; Region: Chol_subst-bind; pfam09129 1435356010867 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1435356010868 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1435356010869 putative active site [active] 1435356010870 putative metal binding site [ion binding]; other site 1435356010871 Yqey-like protein; Region: YqeY; pfam09424 1435356010872 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1435356010873 Transglycosylase; Region: Transgly; pfam00912 1435356010874 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1435356010875 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1435356010876 Transcription factor WhiB; Region: Whib; pfam02467 1435356010877 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1435356010878 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1435356010879 P loop; other site 1435356010880 Nucleotide binding site [chemical binding]; other site 1435356010881 DTAP/Switch II; other site 1435356010882 Switch I; other site 1435356010883 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1435356010884 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1435356010885 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1435356010886 P loop; other site 1435356010887 Nucleotide binding site [chemical binding]; other site 1435356010888 DTAP/Switch II; other site 1435356010889 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1435356010890 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1435356010891 homotrimer interaction site [polypeptide binding]; other site 1435356010892 putative active site [active] 1435356010893 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1435356010894 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1435356010895 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1435356010896 ligand binding site [chemical binding]; other site 1435356010897 flexible hinge region; other site 1435356010898 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1435356010899 putative switch regulator; other site 1435356010900 non-specific DNA interactions [nucleotide binding]; other site 1435356010901 DNA binding site [nucleotide binding] 1435356010902 sequence specific DNA binding site [nucleotide binding]; other site 1435356010903 putative cAMP binding site [chemical binding]; other site 1435356010904 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1435356010905 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1435356010906 minor groove reading motif; other site 1435356010907 helix-hairpin-helix signature motif; other site 1435356010908 substrate binding pocket [chemical binding]; other site 1435356010909 active site 1435356010910 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1435356010911 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1435356010912 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1435356010913 catalytic residues [active] 1435356010914 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1435356010915 putative active site [active] 1435356010916 putative CoA binding site [chemical binding]; other site 1435356010917 nudix motif; other site 1435356010918 metal binding site [ion binding]; metal-binding site 1435356010919 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1435356010920 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1435356010921 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1435356010922 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 1435356010923 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 1435356010924 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356010925 metabolite-proton symporter; Region: 2A0106; TIGR00883 1435356010926 putative substrate translocation pore; other site 1435356010927 acetyl-CoA synthetase; Provisional; Region: PRK00174 1435356010928 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1435356010929 active site 1435356010930 CoA binding site [chemical binding]; other site 1435356010931 acyl-activating enzyme (AAE) consensus motif; other site 1435356010932 AMP binding site [chemical binding]; other site 1435356010933 acetate binding site [chemical binding]; other site 1435356010934 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1435356010935 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1435356010936 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1435356010937 motif II; other site 1435356010938 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 1435356010939 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1435356010940 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1435356010941 Walker A motif; other site 1435356010942 hexamer interface [polypeptide binding]; other site 1435356010943 ATP binding site [chemical binding]; other site 1435356010944 Walker B motif; other site 1435356010945 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 1435356010946 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 1435356010947 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 1435356010948 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1435356010949 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1435356010950 ATP binding site [chemical binding]; other site 1435356010951 putative Mg++ binding site [ion binding]; other site 1435356010952 nucleotide binding region [chemical binding]; other site 1435356010953 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1435356010954 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1435356010955 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1435356010956 DNA-binding site [nucleotide binding]; DNA binding site 1435356010957 RNA-binding motif; other site 1435356010958 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1435356010959 DNA topoisomerase I, bacterial; Region: topA_bact; TIGR01051 1435356010960 active site 1435356010961 interdomain interaction site; other site 1435356010962 putative metal-binding site [ion binding]; other site 1435356010963 nucleotide binding site [chemical binding]; other site 1435356010964 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 1435356010965 domain I; other site 1435356010966 phosphate binding site [ion binding]; other site 1435356010967 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1435356010968 domain II; other site 1435356010969 domain III; other site 1435356010970 nucleotide binding site [chemical binding]; other site 1435356010971 DNA binding groove [nucleotide binding] 1435356010972 catalytic site [active] 1435356010973 domain IV; other site 1435356010974 Uncharacterized C-terminal domain of topoisomerase IA [General function prediction only]; Region: COG1754 1435356010975 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1435356010976 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1435356010977 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1435356010978 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1435356010979 active site 1435356010980 metal binding site [ion binding]; metal-binding site 1435356010981 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1435356010982 DNA polymerase III subunit delta'; Validated; Region: PRK07940 1435356010983 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1435356010984 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 1435356010985 Zn binding site [ion binding]; other site 1435356010986 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1435356010987 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1435356010988 acyl-activating enzyme (AAE) consensus motif; other site 1435356010989 AMP binding site [chemical binding]; other site 1435356010990 active site 1435356010991 CoA binding site [chemical binding]; other site 1435356010992 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1435356010993 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 1435356010994 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1435356010995 putative trimer interface [polypeptide binding]; other site 1435356010996 putative CoA binding site [chemical binding]; other site 1435356010997 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1435356010998 putative trimer interface [polypeptide binding]; other site 1435356010999 putative CoA binding site [chemical binding]; other site 1435356011000 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1435356011001 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1435356011002 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1435356011003 catalytic residue [active] 1435356011004 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1435356011005 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1435356011006 DNA binding site [nucleotide binding] 1435356011007 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 1435356011008 putative deacylase active site [active] 1435356011009 enoyl-CoA hydratase; Provisional; Region: PRK06142 1435356011010 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1435356011011 substrate binding site [chemical binding]; other site 1435356011012 oxyanion hole (OAH) forming residues; other site 1435356011013 trimer interface [polypeptide binding]; other site 1435356011014 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1435356011015 dimer interface [polypeptide binding]; other site 1435356011016 substrate binding site [chemical binding]; other site 1435356011017 metal binding sites [ion binding]; metal-binding site 1435356011018 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1435356011019 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1435356011020 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1435356011021 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 1435356011022 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1435356011023 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1435356011024 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1435356011025 active site 1435356011026 FtsH Extracellular; Region: FtsH_ext; pfam06480 1435356011027 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1435356011028 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1435356011029 Walker A motif; other site 1435356011030 ATP binding site [chemical binding]; other site 1435356011031 Walker B motif; other site 1435356011032 arginine finger; other site 1435356011033 Peptidase family M41; Region: Peptidase_M41; pfam01434 1435356011034 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1435356011035 homodecamer interface [polypeptide binding]; other site 1435356011036 GTP cyclohydrolase I; Provisional; Region: PLN03044 1435356011037 active site 1435356011038 putative catalytic site residues [active] 1435356011039 zinc binding site [ion binding]; other site 1435356011040 GTP-CH-I/GFRP interaction surface; other site 1435356011041 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1435356011042 dihydropteroate synthase; Region: DHPS; TIGR01496 1435356011043 substrate binding pocket [chemical binding]; other site 1435356011044 dimer interface [polypeptide binding]; other site 1435356011045 inhibitor binding site; inhibition site 1435356011046 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1435356011047 homooctamer interface [polypeptide binding]; other site 1435356011048 active site 1435356011049 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1435356011050 catalytic center binding site [active] 1435356011051 ATP binding site [chemical binding]; other site 1435356011052 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 1435356011053 Uncharacterized conserved protein [Function unknown]; Region: COG5495 1435356011054 Rossmann-like domain; Region: Rossmann-like; pfam10727 1435356011055 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 1435356011056 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1435356011057 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1435356011058 active site 1435356011059 ATP-binding site [chemical binding]; other site 1435356011060 pantoate-binding site; other site 1435356011061 HXXH motif; other site 1435356011062 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1435356011063 tetramerization interface [polypeptide binding]; other site 1435356011064 active site 1435356011065 pantothenate kinase; Reviewed; Region: PRK13318 1435356011066 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1435356011067 active site residue [active] 1435356011068 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1435356011069 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1435356011070 dimer interface [polypeptide binding]; other site 1435356011071 putative anticodon binding site; other site 1435356011072 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1435356011073 motif 1; other site 1435356011074 dimer interface [polypeptide binding]; other site 1435356011075 active site 1435356011076 motif 2; other site 1435356011077 motif 3; other site 1435356011078 Lsr2; Region: Lsr2; pfam11774 1435356011079 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 1435356011080 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 1435356011081 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1435356011082 putative active site [active] 1435356011083 putative active site [active] 1435356011084 catalytic site [active] 1435356011085 catalytic site [active] 1435356011086 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 1435356011087 putative active site [active] 1435356011088 catalytic site [active] 1435356011089 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1435356011090 Clp amino terminal domain; Region: Clp_N; pfam02861 1435356011091 Clp amino terminal domain; Region: Clp_N; pfam02861 1435356011092 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1435356011093 Walker A motif; other site 1435356011094 ATP binding site [chemical binding]; other site 1435356011095 Walker B motif; other site 1435356011096 arginine finger; other site 1435356011097 UvrB/uvrC motif; Region: UVR; pfam02151 1435356011098 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1435356011099 Walker A motif; other site 1435356011100 ATP binding site [chemical binding]; other site 1435356011101 Walker B motif; other site 1435356011102 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1435356011103 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1435356011104 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356011105 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356011106 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 1435356011107 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1435356011108 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1435356011109 catalytic residues [active] 1435356011110 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 1435356011111 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1435356011112 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1435356011113 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1435356011114 catalytic site [active] 1435356011115 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1435356011116 endonuclease III; Region: ENDO3c; smart00478 1435356011117 minor groove reading motif; other site 1435356011118 helix-hairpin-helix signature motif; other site 1435356011119 substrate binding pocket [chemical binding]; other site 1435356011120 active site 1435356011121 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 1435356011122 active site clefts [active] 1435356011123 zinc binding site [ion binding]; other site 1435356011124 dimer interface [polypeptide binding]; other site 1435356011125 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1435356011126 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1435356011127 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1435356011128 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1435356011129 CoenzymeA binding site [chemical binding]; other site 1435356011130 subunit interaction site [polypeptide binding]; other site 1435356011131 PHB binding site; other site 1435356011132 DNA polymerase IV; Validated; Region: PRK03858 1435356011133 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1435356011134 active site 1435356011135 DNA binding site [nucleotide binding] 1435356011136 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1435356011137 DNA repair protein RadA; Provisional; Region: PRK11823 1435356011138 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1435356011139 Walker A motif; other site 1435356011140 ATP binding site [chemical binding]; other site 1435356011141 Walker B motif; other site 1435356011142 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1435356011143 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1435356011144 substrate binding site; other site 1435356011145 dimer interface; other site 1435356011146 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1435356011147 homotrimer interaction site [polypeptide binding]; other site 1435356011148 zinc binding site [ion binding]; other site 1435356011149 CDP-binding sites; other site 1435356011150 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1435356011151 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1435356011152 active site 1435356011153 HIGH motif; other site 1435356011154 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1435356011155 KMSKS motif; other site 1435356011156 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1435356011157 tRNA binding surface [nucleotide binding]; other site 1435356011158 anticodon binding site; other site 1435356011159 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1435356011160 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1435356011161 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1435356011162 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1435356011163 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1435356011164 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 1435356011165 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1435356011166 MgtE intracellular N domain; Region: MgtE_N; pfam03448 1435356011167 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1435356011168 Divalent cation transporter; Region: MgtE; pfam01769 1435356011169 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1435356011170 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1435356011171 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1435356011172 putative active site [active] 1435356011173 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1435356011174 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1435356011175 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1435356011176 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1435356011177 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1435356011178 Walker A/P-loop; other site 1435356011179 ATP binding site [chemical binding]; other site 1435356011180 Q-loop/lid; other site 1435356011181 ABC transporter signature motif; other site 1435356011182 Walker B; other site 1435356011183 D-loop; other site 1435356011184 H-loop/switch region; other site 1435356011185 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1435356011186 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1435356011187 intersubunit interface [polypeptide binding]; other site 1435356011188 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1435356011189 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1435356011190 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1435356011191 DNA binding site [nucleotide binding] 1435356011192 domain linker motif; other site 1435356011193 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 1435356011194 putative dimerization interface [polypeptide binding]; other site 1435356011195 putative ligand binding site [chemical binding]; other site 1435356011196 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1435356011197 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 1435356011198 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1435356011199 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1435356011200 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356011201 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356011202 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1435356011203 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1435356011204 active site 1435356011205 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1435356011206 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1435356011207 active site 1435356011208 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1435356011209 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1435356011210 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1435356011211 active site 1435356011212 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1435356011213 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1435356011214 active site 1435356011215 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1435356011216 active site 1435356011217 catalytic site [active] 1435356011218 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1435356011219 DUF35 OB-fold domain; Region: DUF35; pfam01796 1435356011220 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 1435356011221 putative active site [active] 1435356011222 putative catalytic site [active] 1435356011223 lipid-transfer protein; Provisional; Region: PRK07855 1435356011224 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1435356011225 active site 1435356011226 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 1435356011227 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 1435356011228 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1435356011229 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1435356011230 NAD(P) binding site [chemical binding]; other site 1435356011231 active site 1435356011232 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1435356011233 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1435356011234 Walker A/P-loop; other site 1435356011235 ATP binding site [chemical binding]; other site 1435356011236 Q-loop/lid; other site 1435356011237 ABC transporter signature motif; other site 1435356011238 Walker B; other site 1435356011239 D-loop; other site 1435356011240 H-loop/switch region; other site 1435356011241 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1435356011242 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1435356011243 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1435356011244 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1435356011245 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1435356011246 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1435356011247 FAD binding domain; Region: FAD_binding_4; pfam01565 1435356011248 Cholesterol oxidase, substrate-binding; Region: Chol_subst-bind; pfam09129 1435356011249 enoyl-CoA hydratase; Region: PLN02864 1435356011250 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 1435356011251 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 1435356011252 dimer interaction site [polypeptide binding]; other site 1435356011253 substrate-binding tunnel; other site 1435356011254 active site 1435356011255 catalytic site [active] 1435356011256 substrate binding site [chemical binding]; other site 1435356011257 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 1435356011258 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1435356011259 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1435356011260 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 1435356011261 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1435356011262 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 1435356011263 Flavin binding site [chemical binding]; other site 1435356011264 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 1435356011265 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1435356011266 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1435356011267 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 1435356011268 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 1435356011269 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 1435356011270 active site 1435356011271 Fe binding site [ion binding]; other site 1435356011272 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1435356011273 PRC-barrel domain; Region: PRC; pfam05239 1435356011274 4-aminobutyrate aminotransferase; Provisional; Region: PRK08117 1435356011275 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1435356011276 inhibitor-cofactor binding pocket; inhibition site 1435356011277 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1435356011278 catalytic residue [active] 1435356011279 Protein of unknown function (DUF3830); Region: DUF3830; pfam12903 1435356011280 putative amidase; Provisional; Region: PRK06169 1435356011281 Amidase; Region: Amidase; pfam01425 1435356011282 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 1435356011283 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1435356011284 NAD binding site [chemical binding]; other site 1435356011285 ligand binding site [chemical binding]; other site 1435356011286 catalytic site [active] 1435356011287 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1435356011288 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1435356011289 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1435356011290 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1435356011291 DNA-binding site [nucleotide binding]; DNA binding site 1435356011292 FCD domain; Region: FCD; pfam07729 1435356011293 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356011294 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356011295 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 1435356011296 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1435356011297 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1435356011298 active site 1435356011299 catalytic tetrad [active] 1435356011300 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1435356011301 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1435356011302 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1435356011303 active site 1435356011304 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1435356011305 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1435356011306 active site 1435356011307 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1435356011308 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1435356011309 active site 1435356011310 enoyl-CoA hydratase; Provisional; Region: PRK08290 1435356011311 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1435356011312 substrate binding site [chemical binding]; other site 1435356011313 oxyanion hole (OAH) forming residues; other site 1435356011314 trimer interface [polypeptide binding]; other site 1435356011315 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1435356011316 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1435356011317 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1435356011318 acyl-activating enzyme (AAE) consensus motif; other site 1435356011319 putative AMP binding site [chemical binding]; other site 1435356011320 putative active site [active] 1435356011321 putative CoA binding site [chemical binding]; other site 1435356011322 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1435356011323 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1435356011324 active site 1435356011325 short chain dehydrogenase; Provisional; Region: PRK07831 1435356011326 classical (c) SDRs; Region: SDR_c; cd05233 1435356011327 NAD(P) binding site [chemical binding]; other site 1435356011328 active site 1435356011329 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356011330 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356011331 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1435356011332 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1435356011333 dimer interface [polypeptide binding]; other site 1435356011334 active site 1435356011335 Uncharacterized conserved protein (DUF2277); Region: DUF2277; cl02349 1435356011336 carbon starvation protein A; Provisional; Region: PRK15015 1435356011337 Carbon starvation protein CstA; Region: CstA; pfam02554 1435356011338 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1435356011339 Protein of unknown function (DUF466); Region: DUF466; pfam04328 1435356011340 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1435356011341 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1435356011342 active site 1435356011343 phosphorylation site [posttranslational modification] 1435356011344 intermolecular recognition site; other site 1435356011345 dimerization interface [polypeptide binding]; other site 1435356011346 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1435356011347 DNA binding residues [nucleotide binding] 1435356011348 dimerization interface [polypeptide binding]; other site 1435356011349 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1435356011350 Histidine kinase; Region: HisKA_3; pfam07730 1435356011351 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1435356011352 ATP binding site [chemical binding]; other site 1435356011353 Mg2+ binding site [ion binding]; other site 1435356011354 G-X-G motif; other site 1435356011355 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1435356011356 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1435356011357 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1435356011358 Walker A/P-loop; other site 1435356011359 ATP binding site [chemical binding]; other site 1435356011360 Q-loop/lid; other site 1435356011361 ABC transporter signature motif; other site 1435356011362 Walker B; other site 1435356011363 D-loop; other site 1435356011364 H-loop/switch region; other site 1435356011365 Nitronate monooxygenase; Region: NMO; pfam03060 1435356011366 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1435356011367 FMN binding site [chemical binding]; other site 1435356011368 substrate binding site [chemical binding]; other site 1435356011369 putative catalytic residue [active] 1435356011370 Coenzyme A transferase; Region: CoA_trans; cl17247 1435356011371 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1435356011372 enoyl-CoA hydratase; Provisional; Region: PRK06495 1435356011373 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1435356011374 substrate binding site [chemical binding]; other site 1435356011375 oxyanion hole (OAH) forming residues; other site 1435356011376 trimer interface [polypeptide binding]; other site 1435356011377 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 1435356011378 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1435356011379 dimer interface [polypeptide binding]; other site 1435356011380 active site 1435356011381 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356011382 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356011383 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1435356011384 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1435356011385 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1435356011386 acyl-activating enzyme (AAE) consensus motif; other site 1435356011387 acyl-activating enzyme (AAE) consensus motif; other site 1435356011388 AMP binding site [chemical binding]; other site 1435356011389 active site 1435356011390 CoA binding site [chemical binding]; other site 1435356011391 enoyl-CoA hydratase; Region: PLN02864 1435356011392 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1435356011393 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1435356011394 active site 2 [active] 1435356011395 active site 1 [active] 1435356011396 acyl-CoA synthetase; Provisional; Region: PRK13388 1435356011397 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1435356011398 acyl-activating enzyme (AAE) consensus motif; other site 1435356011399 AMP binding site [chemical binding]; other site 1435356011400 active site 1435356011401 CoA binding site [chemical binding]; other site 1435356011402 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1435356011403 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 1435356011404 classical (c) SDRs; Region: SDR_c; cd05233 1435356011405 NAD(P) binding site [chemical binding]; other site 1435356011406 active site 1435356011407 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1435356011408 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1435356011409 FAD binding pocket [chemical binding]; other site 1435356011410 FAD binding motif [chemical binding]; other site 1435356011411 phosphate binding motif [ion binding]; other site 1435356011412 beta-alpha-beta structure motif; other site 1435356011413 NAD(p) ribose binding residues [chemical binding]; other site 1435356011414 NAD binding pocket [chemical binding]; other site 1435356011415 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1435356011416 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1435356011417 catalytic loop [active] 1435356011418 iron binding site [ion binding]; other site 1435356011419 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356011420 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356011421 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1435356011422 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1435356011423 phosphate binding site [ion binding]; other site 1435356011424 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1435356011425 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1435356011426 Bacterial transcriptional regulator; Region: IclR; pfam01614 1435356011427 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 1435356011428 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1435356011429 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1435356011430 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1435356011431 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 1435356011432 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 1435356011433 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 1435356011434 active site 1435356011435 Fe binding site [ion binding]; other site 1435356011436 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 1435356011437 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1435356011438 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1435356011439 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1435356011440 ATP binding site [chemical binding]; other site 1435356011441 Mg2+ binding site [ion binding]; other site 1435356011442 G-X-G motif; other site 1435356011443 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356011444 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1435356011445 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356011446 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356011447 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1435356011448 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1435356011449 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1435356011450 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1435356011451 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1435356011452 active site 1435356011453 lipid-transfer protein; Provisional; Region: PRK07855 1435356011454 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1435356011455 active site 1435356011456 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1435356011457 active site 2 [active] 1435356011458 active site 1 [active] 1435356011459 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1435356011460 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1435356011461 DUF35 OB-fold domain; Region: DUF35; pfam01796 1435356011462 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1435356011463 active site 2 [active] 1435356011464 active site 1 [active] 1435356011465 short chain dehydrogenase; Provisional; Region: PRK07856 1435356011466 classical (c) SDRs; Region: SDR_c; cd05233 1435356011467 NAD(P) binding site [chemical binding]; other site 1435356011468 active site 1435356011469 short chain dehydrogenase; Provisional; Region: PRK07791 1435356011470 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1435356011471 NAD(P) binding site [chemical binding]; other site 1435356011472 active site 1435356011473 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 1435356011474 primary dimer interface [polypeptide binding]; other site 1435356011475 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1435356011476 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1435356011477 Coenzyme A binding pocket [chemical binding]; other site 1435356011478 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1435356011479 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 1435356011480 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1435356011481 dimer interface [polypeptide binding]; other site 1435356011482 active site 1435356011483 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1435356011484 Cytochrome P450; Region: p450; cl12078 1435356011485 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1435356011486 Ligand binding site; other site 1435356011487 metal-binding site 1435356011488 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1435356011489 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1435356011490 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1435356011491 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1435356011492 phosphate binding site [ion binding]; other site 1435356011493 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 1435356011494 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1435356011495 active site 1435356011496 lipid-transfer protein; Provisional; Region: PRK07937 1435356011497 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1435356011498 active site 1435356011499 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1435356011500 DUF35 OB-fold domain; Region: DUF35; pfam01796 1435356011501 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1435356011502 DUF35 OB-fold domain; Region: DUF35; pfam01796 1435356011503 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1435356011504 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1435356011505 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 1435356011506 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1435356011507 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1435356011508 acyl-activating enzyme (AAE) consensus motif; other site 1435356011509 putative AMP binding site [chemical binding]; other site 1435356011510 putative active site [active] 1435356011511 putative CoA binding site [chemical binding]; other site 1435356011512 enoyl-CoA hydratase; Provisional; Region: PRK07799 1435356011513 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1435356011514 substrate binding site [chemical binding]; other site 1435356011515 oxyanion hole (OAH) forming residues; other site 1435356011516 trimer interface [polypeptide binding]; other site 1435356011517 acyl-CoA synthetase; Validated; Region: PRK07798 1435356011518 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1435356011519 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 1435356011520 acyl-activating enzyme (AAE) consensus motif; other site 1435356011521 acyl-activating enzyme (AAE) consensus motif; other site 1435356011522 putative AMP binding site [chemical binding]; other site 1435356011523 putative active site [active] 1435356011524 putative CoA binding site [chemical binding]; other site 1435356011525 Nitronate monooxygenase; Region: NMO; pfam03060 1435356011526 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1435356011527 FMN binding site [chemical binding]; other site 1435356011528 substrate binding site [chemical binding]; other site 1435356011529 putative catalytic residue [active] 1435356011530 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1435356011531 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1435356011532 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1435356011533 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1435356011534 FMN binding site [chemical binding]; other site 1435356011535 substrate binding site [chemical binding]; other site 1435356011536 putative catalytic residue [active] 1435356011537 Protein of unknown function (DUF3253); Region: DUF3253; pfam11625 1435356011538 acyl-CoA synthetase; Validated; Region: PRK07867 1435356011539 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 1435356011540 acyl-activating enzyme (AAE) consensus motif; other site 1435356011541 putative AMP binding site [chemical binding]; other site 1435356011542 putative active site [active] 1435356011543 putative CoA binding site [chemical binding]; other site 1435356011544 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1435356011545 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1435356011546 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1435356011547 active site 1435356011548 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1435356011549 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1435356011550 FAD binding site [chemical binding]; other site 1435356011551 substrate binding site [chemical binding]; other site 1435356011552 catalytic base [active] 1435356011553 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1435356011554 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1435356011555 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 1435356011556 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1435356011557 NAD(P) binding site [chemical binding]; other site 1435356011558 active site 1435356011559 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1435356011560 Permease; Region: Permease; pfam02405 1435356011561 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1435356011562 Permease; Region: Permease; pfam02405 1435356011563 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1435356011564 mce related protein; Region: MCE; pfam02470 1435356011565 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1435356011566 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1435356011567 mce related protein; Region: MCE; pfam02470 1435356011568 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1435356011569 mce related protein; Region: MCE; pfam02470 1435356011570 mce related protein; Region: MCE; pfam02470 1435356011571 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1435356011572 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1435356011573 mce related protein; Region: MCE; pfam02470 1435356011574 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1435356011575 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1435356011576 mce related protein; Region: MCE; pfam02470 1435356011577 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 1435356011578 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1435356011579 active site 1435356011580 homotetramer interface [polypeptide binding]; other site 1435356011581 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1435356011582 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1435356011583 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1435356011584 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 1435356011585 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1435356011586 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 1435356011587 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1435356011588 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1435356011589 Uncharacterized conserved protein [Function unknown]; Region: COG3610 1435356011590 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356011591 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356011592 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1435356011593 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1435356011594 substrate binding site [chemical binding]; other site 1435356011595 dimer interface [polypeptide binding]; other site 1435356011596 ATP binding site [chemical binding]; other site 1435356011597 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1435356011598 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1435356011599 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356011600 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1435356011601 nucleotide binding site/active site [active] 1435356011602 HIT family signature motif; other site 1435356011603 catalytic residue [active] 1435356011604 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1435356011605 dimerization interface [polypeptide binding]; other site 1435356011606 putative DNA binding site [nucleotide binding]; other site 1435356011607 putative Zn2+ binding site [ion binding]; other site 1435356011608 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1435356011609 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 1435356011610 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1435356011611 active site 1435356011612 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1435356011613 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1435356011614 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1435356011615 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1435356011616 Predicted acyl esterases [General function prediction only]; Region: COG2936 1435356011617 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 1435356011618 aspartate aminotransferase; Provisional; Region: PRK05764 1435356011619 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1435356011620 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1435356011621 homodimer interface [polypeptide binding]; other site 1435356011622 catalytic residue [active] 1435356011623 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1435356011624 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1435356011625 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356011626 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1435356011627 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 1435356011628 tetramer interface [polypeptide binding]; other site 1435356011629 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1435356011630 HIT family signature motif; other site 1435356011631 catalytic residue [active] 1435356011632 L-lactate permease; Region: Lactate_perm; cl00701 1435356011633 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1435356011634 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 1435356011635 Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454 1435356011636 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1435356011637 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1435356011638 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1435356011639 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1435356011640 dimerization interface [polypeptide binding]; other site 1435356011641 putative DNA binding site [nucleotide binding]; other site 1435356011642 putative Zn2+ binding site [ion binding]; other site 1435356011643 PE-PPE domain; Region: PE-PPE; pfam08237 1435356011644 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 1435356011645 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1435356011646 classical (c) SDRs; Region: SDR_c; cd05233 1435356011647 NAD(P) binding site [chemical binding]; other site 1435356011648 active site 1435356011649 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 1435356011650 active site 1435356011651 substrate binding pocket [chemical binding]; other site 1435356011652 homodimer interaction site [polypeptide binding]; other site 1435356011653 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 1435356011654 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1435356011655 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1435356011656 MarR family; Region: MarR_2; cl17246 1435356011657 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1435356011658 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1435356011659 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1435356011660 Walker A/P-loop; other site 1435356011661 ATP binding site [chemical binding]; other site 1435356011662 Q-loop/lid; other site 1435356011663 ABC transporter signature motif; other site 1435356011664 Walker B; other site 1435356011665 D-loop; other site 1435356011666 H-loop/switch region; other site 1435356011667 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 1435356011668 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1435356011669 acyl-activating enzyme (AAE) consensus motif; other site 1435356011670 active site 1435356011671 AMP binding site [chemical binding]; other site 1435356011672 substrate binding site [chemical binding]; other site 1435356011673 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1435356011674 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316 1435356011675 NAD(P) binding site [chemical binding]; other site 1435356011676 active site 1435356011677 isochorismate synthase DhbC; Validated; Region: PRK06923 1435356011678 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1435356011679 Condensation domain; Region: Condensation; pfam00668 1435356011680 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1435356011681 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1435356011682 acyl-activating enzyme (AAE) consensus motif; other site 1435356011683 AMP binding site [chemical binding]; other site 1435356011684 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1435356011685 Condensation domain; Region: Condensation; pfam00668 1435356011686 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1435356011687 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1435356011688 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1435356011689 acyl-activating enzyme (AAE) consensus motif; other site 1435356011690 AMP binding site [chemical binding]; other site 1435356011691 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1435356011692 Condensation domain; Region: Condensation; pfam00668 1435356011693 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1435356011694 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1435356011695 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1435356011696 intersubunit interface [polypeptide binding]; other site 1435356011697 Condensation domain; Region: Condensation; pfam00668 1435356011698 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1435356011699 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1435356011700 acyl-activating enzyme (AAE) consensus motif; other site 1435356011701 AMP binding site [chemical binding]; other site 1435356011702 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1435356011703 Condensation domain; Region: Condensation; pfam00668 1435356011704 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1435356011705 Condensation domain; Region: Condensation; pfam00668 1435356011706 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1435356011707 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1435356011708 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1435356011709 acyl-activating enzyme (AAE) consensus motif; other site 1435356011710 AMP binding site [chemical binding]; other site 1435356011711 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1435356011712 Condensation domain; Region: Condensation; pfam00668 1435356011713 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1435356011714 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1435356011715 enterobactin exporter EntS; Provisional; Region: PRK10489 1435356011716 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356011717 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1435356011718 putative substrate translocation pore; other site 1435356011719 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1435356011720 ATP binding site [chemical binding]; other site 1435356011721 active site 1435356011722 substrate binding site [chemical binding]; other site 1435356011723 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1435356011724 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1435356011725 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1435356011726 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1435356011727 active site 1435356011728 phosphorylation site [posttranslational modification] 1435356011729 intermolecular recognition site; other site 1435356011730 dimerization interface [polypeptide binding]; other site 1435356011731 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1435356011732 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1435356011733 ATP binding site [chemical binding]; other site 1435356011734 Mg2+ binding site [ion binding]; other site 1435356011735 G-X-G motif; other site 1435356011736 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1435356011737 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1435356011738 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1435356011739 catalytic residues [active] 1435356011740 dimer interface [polypeptide binding]; other site 1435356011741 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 1435356011742 putative FMN binding site [chemical binding]; other site 1435356011743 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1435356011744 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 1435356011745 active site 1435356011746 FMN binding site [chemical binding]; other site 1435356011747 substrate binding site [chemical binding]; other site 1435356011748 putative catalytic residue [active] 1435356011749 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1435356011750 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1435356011751 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1435356011752 Predicted deacetylase [General function prediction only]; Region: COG3233 1435356011753 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1435356011754 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1435356011755 FAD binding domain; Region: FAD_binding_2; pfam00890 1435356011756 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1435356011757 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 1435356011758 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1435356011759 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1435356011760 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1435356011761 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1435356011762 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1435356011763 putative active site [active] 1435356011764 catalytic triad [active] 1435356011765 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1435356011766 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1435356011767 active site 1435356011768 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 1435356011769 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1435356011770 active site 1435356011771 metal binding site [ion binding]; metal-binding site 1435356011772 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1435356011773 putative active site [active] 1435356011774 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1435356011775 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1435356011776 dimerization interface [polypeptide binding]; other site 1435356011777 ATP binding site [chemical binding]; other site 1435356011778 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1435356011779 dimerization interface [polypeptide binding]; other site 1435356011780 ATP binding site [chemical binding]; other site 1435356011781 Predicted membrane protein [Function unknown]; Region: COG4425 1435356011782 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 1435356011783 CAAX protease self-immunity; Region: Abi; pfam02517 1435356011784 amidophosphoribosyltransferase; Provisional; Region: PRK07847 1435356011785 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1435356011786 active site 1435356011787 tetramer interface [polypeptide binding]; other site 1435356011788 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1435356011789 active site 1435356011790 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1435356011791 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1435356011792 dimerization interface [polypeptide binding]; other site 1435356011793 putative ATP binding site [chemical binding]; other site 1435356011794 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 1435356011795 L-asparaginase II; Region: Asparaginase_II; pfam06089 1435356011796 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1435356011797 MOSC domain; Region: MOSC; pfam03473 1435356011798 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1435356011799 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1435356011800 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1435356011801 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1435356011802 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1435356011803 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1435356011804 catalytic residue [active] 1435356011805 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1435356011806 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1435356011807 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1435356011808 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1435356011809 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1435356011810 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1435356011811 Walker A/P-loop; other site 1435356011812 ATP binding site [chemical binding]; other site 1435356011813 ABC transporter; Region: ABC_tran; pfam00005 1435356011814 Q-loop/lid; other site 1435356011815 ABC transporter signature motif; other site 1435356011816 Walker B; other site 1435356011817 D-loop; other site 1435356011818 H-loop/switch region; other site 1435356011819 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 1435356011820 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1435356011821 Walker A/P-loop; other site 1435356011822 ATP binding site [chemical binding]; other site 1435356011823 Q-loop/lid; other site 1435356011824 ABC transporter signature motif; other site 1435356011825 Walker B; other site 1435356011826 D-loop; other site 1435356011827 H-loop/switch region; other site 1435356011828 BCCT family transporter; Region: BCCT; pfam02028 1435356011829 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1435356011830 heme-binding site [chemical binding]; other site 1435356011831 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 1435356011832 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1435356011833 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1435356011834 active site residue [active] 1435356011835 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1435356011836 active site residue [active] 1435356011837 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 1435356011838 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1435356011839 catalytic residues [active] 1435356011840 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1435356011841 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1435356011842 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1435356011843 DNA binding site [nucleotide binding] 1435356011844 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 1435356011845 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1435356011846 Coenzyme A binding pocket [chemical binding]; other site 1435356011847 PBP superfamily domain; Region: PBP_like_2; cl17296 1435356011848 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1435356011849 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1435356011850 dimer interface [polypeptide binding]; other site 1435356011851 conserved gate region; other site 1435356011852 putative PBP binding loops; other site 1435356011853 ABC-ATPase subunit interface; other site 1435356011854 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1435356011855 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1435356011856 dimer interface [polypeptide binding]; other site 1435356011857 conserved gate region; other site 1435356011858 putative PBP binding loops; other site 1435356011859 ABC-ATPase subunit interface; other site 1435356011860 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 1435356011861 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1435356011862 Walker A/P-loop; other site 1435356011863 ATP binding site [chemical binding]; other site 1435356011864 Q-loop/lid; other site 1435356011865 ABC transporter signature motif; other site 1435356011866 Walker B; other site 1435356011867 D-loop; other site 1435356011868 H-loop/switch region; other site 1435356011869 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1435356011870 PhoU domain; Region: PhoU; pfam01895 1435356011871 PhoU domain; Region: PhoU; pfam01895 1435356011872 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1435356011873 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1435356011874 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1435356011875 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1435356011876 FMN binding site [chemical binding]; other site 1435356011877 active site 1435356011878 catalytic residues [active] 1435356011879 substrate binding site [chemical binding]; other site 1435356011880 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 1435356011881 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 1435356011882 homodimer interface [polypeptide binding]; other site 1435356011883 putative substrate binding pocket [chemical binding]; other site 1435356011884 diiron center [ion binding]; other site 1435356011885 Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078 1435356011886 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356011887 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356011888 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1435356011889 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1435356011890 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1435356011891 S-adenosylmethionine binding site [chemical binding]; other site 1435356011892 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 1435356011893 Protein of unknown function, DUF608; Region: DUF608; pfam04685 1435356011894 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1435356011895 Ecdysteroid kinase; Region: EcKinase; cl17738 1435356011896 Phosphotransferase enzyme family; Region: APH; pfam01636 1435356011897 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1435356011898 hypothetical protein; Validated; Region: PRK07121 1435356011899 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1435356011900 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1435356011901 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1435356011902 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1435356011903 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356011904 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356011905 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 1435356011906 Na2 binding site [ion binding]; other site 1435356011907 putative substrate binding site 1 [chemical binding]; other site 1435356011908 Na binding site 1 [ion binding]; other site 1435356011909 putative substrate binding site 2 [chemical binding]; other site 1435356011910 Predicted integral membrane protein [Function unknown]; Region: COG0392 1435356011911 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1435356011912 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1435356011913 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1435356011914 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1435356011915 putative acyl-acceptor binding pocket; other site 1435356011916 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 1435356011917 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1435356011918 putative acyl-acceptor binding pocket; other site 1435356011919 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 1435356011920 AAA domain; Region: AAA_33; pfam13671 1435356011921 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1435356011922 active site 1435356011923 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1435356011924 Ligand Binding Site [chemical binding]; other site 1435356011925 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1435356011926 Ligand Binding Site [chemical binding]; other site 1435356011927 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 1435356011928 putative active site; other site 1435356011929 signature motif; other site 1435356011930 putative triphosphate binding site [ion binding]; other site 1435356011931 CHAD domain; Region: CHAD; pfam05235 1435356011932 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 1435356011933 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1435356011934 hydrophobic ligand binding site; other site 1435356011935 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1435356011936 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 1435356011937 probable active site [active] 1435356011938 Predicted esterase [General function prediction only]; Region: COG0627 1435356011939 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1435356011940 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1435356011941 NAD(P) binding site [chemical binding]; other site 1435356011942 active site 1435356011943 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1435356011944 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 1435356011945 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 1435356011946 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1435356011947 Na binding site [ion binding]; other site 1435356011948 putative substrate binding site [chemical binding]; other site 1435356011949 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1435356011950 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1435356011951 DNA-binding site [nucleotide binding]; DNA binding site 1435356011952 FCD domain; Region: FCD; pfam07729 1435356011953 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1435356011954 short chain dehydrogenase; Provisional; Region: PRK06197 1435356011955 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1435356011956 putative NAD(P) binding site [chemical binding]; other site 1435356011957 active site 1435356011958 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1435356011959 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1435356011960 ATP binding site [chemical binding]; other site 1435356011961 putative Mg++ binding site [ion binding]; other site 1435356011962 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1435356011963 nucleotide binding region [chemical binding]; other site 1435356011964 ATP-binding site [chemical binding]; other site 1435356011965 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1435356011966 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1435356011967 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1435356011968 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1435356011969 putative Zn2+ binding site [ion binding]; other site 1435356011970 putative DNA binding site [nucleotide binding]; other site 1435356011971 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1435356011972 Clp amino terminal domain; Region: Clp_N; pfam02861 1435356011973 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1435356011974 Walker A motif; other site 1435356011975 ATP binding site [chemical binding]; other site 1435356011976 Walker B motif; other site 1435356011977 arginine finger; other site 1435356011978 UvrB/uvrC motif; Region: UVR; pfam02151 1435356011979 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1435356011980 Walker A motif; other site 1435356011981 ATP binding site [chemical binding]; other site 1435356011982 Walker B motif; other site 1435356011983 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1435356011984 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 1435356011985 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1435356011986 trehalose synthase; Region: treS_nterm; TIGR02456 1435356011987 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1435356011988 active site 1435356011989 catalytic site [active] 1435356011990 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1435356011991 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1435356011992 active site 1435356011993 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1435356011994 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1435356011995 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1435356011996 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1435356011997 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1435356011998 active site 1435356011999 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 1435356012000 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1435356012001 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1435356012002 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1435356012003 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1435356012004 aminotransferase; Validated; Region: PRK07777 1435356012005 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1435356012006 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1435356012007 homodimer interface [polypeptide binding]; other site 1435356012008 catalytic residue [active] 1435356012009 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1435356012010 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1435356012011 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1435356012012 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1435356012013 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1435356012014 DNA binding residues [nucleotide binding] 1435356012015 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1435356012016 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1435356012017 nudix motif; other site 1435356012018 Domain of unknown function DUF302; Region: DUF302; cl01364 1435356012019 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1435356012020 putative homotetramer interface [polypeptide binding]; other site 1435356012021 putative homodimer interface [polypeptide binding]; other site 1435356012022 putative allosteric switch controlling residues; other site 1435356012023 putative metal binding site [ion binding]; other site 1435356012024 putative homodimer-homodimer interface [polypeptide binding]; other site 1435356012025 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1435356012026 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1435356012027 active site residue [active] 1435356012028 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1435356012029 Rhodanese-like domain; Region: Rhodanese; pfam00581 1435356012030 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1435356012031 active site residue [active] 1435356012032 NMT1/THI5 like; Region: NMT1; pfam09084 1435356012033 NMT1-like family; Region: NMT1_2; pfam13379 1435356012034 substrate binding pocket [chemical binding]; other site 1435356012035 membrane-bound complex binding site; other site 1435356012036 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1435356012037 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1435356012038 Walker A/P-loop; other site 1435356012039 ATP binding site [chemical binding]; other site 1435356012040 Q-loop/lid; other site 1435356012041 ABC transporter signature motif; other site 1435356012042 Walker B; other site 1435356012043 D-loop; other site 1435356012044 H-loop/switch region; other site 1435356012045 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1435356012046 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1435356012047 dimer interface [polypeptide binding]; other site 1435356012048 conserved gate region; other site 1435356012049 putative PBP binding loops; other site 1435356012050 ABC-ATPase subunit interface; other site 1435356012051 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356012052 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1435356012053 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356012054 putative substrate translocation pore; other site 1435356012055 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1435356012056 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1435356012057 Protein of unknown function (DUF3239); Region: DUF3239; pfam11580 1435356012058 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 1435356012059 Citrate transporter; Region: CitMHS; pfam03600 1435356012060 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1435356012061 PAS domain; Region: PAS; smart00091 1435356012062 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1435356012063 Mg2+ binding site [ion binding]; other site 1435356012064 G-X-G motif; other site 1435356012065 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1435356012066 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1435356012067 active site 1435356012068 phosphorylation site [posttranslational modification] 1435356012069 intermolecular recognition site; other site 1435356012070 dimerization interface [polypeptide binding]; other site 1435356012071 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1435356012072 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1435356012073 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1435356012074 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1435356012075 nucleotide binding region [chemical binding]; other site 1435356012076 ATP-binding site [chemical binding]; other site 1435356012077 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1435356012078 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1435356012079 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1435356012080 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1435356012081 dimer interface [polypeptide binding]; other site 1435356012082 conserved gate region; other site 1435356012083 putative PBP binding loops; other site 1435356012084 ABC-ATPase subunit interface; other site 1435356012085 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1435356012086 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1435356012087 Walker A/P-loop; other site 1435356012088 ATP binding site [chemical binding]; other site 1435356012089 Q-loop/lid; other site 1435356012090 ABC transporter signature motif; other site 1435356012091 Walker B; other site 1435356012092 D-loop; other site 1435356012093 H-loop/switch region; other site 1435356012094 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1435356012095 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1435356012096 active site 1435356012097 non-prolyl cis peptide bond; other site 1435356012098 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1435356012099 WYL domain; Region: WYL; pfam13280 1435356012100 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1435356012101 hypothetical protein; Provisional; Region: PRK11770 1435356012102 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1435356012103 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1435356012104 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1435356012105 DNA-binding site [nucleotide binding]; DNA binding site 1435356012106 RNA-binding motif; other site 1435356012107 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 1435356012108 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356012109 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 1435356012110 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 1435356012111 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1435356012112 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1435356012113 active site 1435356012114 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1435356012115 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1435356012116 MarR family; Region: MarR; pfam01047 1435356012117 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1435356012118 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1435356012119 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 1435356012120 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1435356012121 Short C-terminal domain; Region: SHOCT; pfam09851 1435356012122 Predicted membrane protein [Function unknown]; Region: COG4425 1435356012123 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 1435356012124 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 1435356012125 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1435356012126 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1435356012127 catalytic residue [active] 1435356012128 citrate synthase 2; Provisional; Region: PRK12350 1435356012129 Citrate synthase; Region: Citrate_synt; pfam00285 1435356012130 oxalacetate binding site [chemical binding]; other site 1435356012131 citrylCoA binding site [chemical binding]; other site 1435356012132 coenzyme A binding site [chemical binding]; other site 1435356012133 catalytic triad [active] 1435356012134 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 1435356012135 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1435356012136 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1435356012137 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356012138 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1435356012139 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1435356012140 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1435356012141 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1435356012142 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1435356012143 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1435356012144 dimer interface [polypeptide binding]; other site 1435356012145 active site 1435356012146 citrylCoA binding site [chemical binding]; other site 1435356012147 NADH binding [chemical binding]; other site 1435356012148 cationic pore residues; other site 1435356012149 oxalacetate/citrate binding site [chemical binding]; other site 1435356012150 coenzyme A binding site [chemical binding]; other site 1435356012151 catalytic triad [active] 1435356012152 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1435356012153 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1435356012154 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356012155 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356012156 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1435356012157 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1435356012158 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1435356012159 active site 1435356012160 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1435356012161 Competence-damaged protein; Region: CinA; pfam02464 1435356012162 hypothetical protein; Provisional; Region: PRK14059 1435356012163 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1435356012164 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 1435356012165 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1435356012166 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 1435356012167 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 1435356012168 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 1435356012169 acyl-activating enzyme (AAE) consensus motif; other site 1435356012170 putative AMP binding site [chemical binding]; other site 1435356012171 putative active site [active] 1435356012172 putative CoA binding site [chemical binding]; other site 1435356012173 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 1435356012174 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 1435356012175 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1435356012176 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1435356012177 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1435356012178 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1435356012179 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1435356012180 Walker A/P-loop; other site 1435356012181 ATP binding site [chemical binding]; other site 1435356012182 Q-loop/lid; other site 1435356012183 ABC transporter signature motif; other site 1435356012184 Walker B; other site 1435356012185 D-loop; other site 1435356012186 H-loop/switch region; other site 1435356012187 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1435356012188 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1435356012189 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1435356012190 sequence-specific DNA binding site [nucleotide binding]; other site 1435356012191 salt bridge; other site 1435356012192 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1435356012193 RNA binding surface [nucleotide binding]; other site 1435356012194 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1435356012195 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1435356012196 Walker A/P-loop; other site 1435356012197 ATP binding site [chemical binding]; other site 1435356012198 Q-loop/lid; other site 1435356012199 ABC transporter signature motif; other site 1435356012200 Walker B; other site 1435356012201 D-loop; other site 1435356012202 H-loop/switch region; other site 1435356012203 ABC transporter; Region: ABC_tran_2; pfam12848 1435356012204 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1435356012205 H+ Antiporter protein; Region: 2A0121; TIGR00900 1435356012206 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1435356012207 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1435356012208 protein binding site [polypeptide binding]; other site 1435356012209 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1435356012210 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1435356012211 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 1435356012212 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1435356012213 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 1435356012214 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; cl01837 1435356012215 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1435356012216 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1435356012217 substrate binding site [chemical binding]; other site 1435356012218 oxyanion hole (OAH) forming residues; other site 1435356012219 trimer interface [polypeptide binding]; other site 1435356012220 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1435356012221 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1435356012222 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1435356012223 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 1435356012224 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1435356012225 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 1435356012226 probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885 1435356012227 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1435356012228 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1435356012229 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1435356012230 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1435356012231 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1435356012232 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1435356012233 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1435356012234 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1435356012235 Histidine kinase; Region: His_kinase; pfam06580 1435356012236 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1435356012237 ATP binding site [chemical binding]; other site 1435356012238 Mg2+ binding site [ion binding]; other site 1435356012239 G-X-G motif; other site 1435356012240 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1435356012241 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1435356012242 active site 1435356012243 phosphorylation site [posttranslational modification] 1435356012244 intermolecular recognition site; other site 1435356012245 dimerization interface [polypeptide binding]; other site 1435356012246 LytTr DNA-binding domain; Region: LytTR; smart00850 1435356012247 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1435356012248 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1435356012249 Na binding site [ion binding]; other site 1435356012250 Protein of unknown function, DUF485; Region: DUF485; pfam04341 1435356012251 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1435356012252 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1435356012253 Na binding site [ion binding]; other site 1435356012254 Short C-terminal domain; Region: SHOCT; pfam09851 1435356012255 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1435356012256 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1435356012257 DNA-binding site [nucleotide binding]; DNA binding site 1435356012258 RNA-binding motif; other site 1435356012259 ANTAR domain; Region: ANTAR; pfam03861 1435356012260 Helix-turn-helix domain; Region: HTH_18; pfam12833 1435356012261 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1435356012262 GAF domain; Region: GAF; pfam01590 1435356012263 GAF domain; Region: GAF_2; pfam13185 1435356012264 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1435356012265 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 1435356012266 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 1435356012267 nucleotide binding site [chemical binding]; other site 1435356012268 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 1435356012269 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1435356012270 active site 1435356012271 DNA binding site [nucleotide binding] 1435356012272 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1435356012273 DNA binding site [nucleotide binding] 1435356012274 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1435356012275 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1435356012276 active site 1435356012277 phosphorylation site [posttranslational modification] 1435356012278 intermolecular recognition site; other site 1435356012279 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1435356012280 DNA binding residues [nucleotide binding] 1435356012281 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1435356012282 ATP binding site [chemical binding]; other site 1435356012283 Mg2+ binding site [ion binding]; other site 1435356012284 G-X-G motif; other site 1435356012285 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 1435356012286 DNA binding residues [nucleotide binding] 1435356012287 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1435356012288 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1435356012289 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1435356012290 ATP binding site [chemical binding]; other site 1435356012291 Mg2+ binding site [ion binding]; other site 1435356012292 G-X-G motif; other site 1435356012293 hypothetical protein; Provisional; Region: PRK02237 1435356012294 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1435356012295 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1435356012296 active site 1435356012297 Predicted transcriptional regulator [Transcription]; Region: COG2378 1435356012298 HTH domain; Region: HTH_11; pfam08279 1435356012299 WYL domain; Region: WYL; pfam13280 1435356012300 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1435356012301 active site 1435356012302 metal binding site [ion binding]; metal-binding site 1435356012303 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1435356012304 Hypothetical protein TTHB210, a sigma(E)-regulated gene product found in Thermus thermophilus, and similar proteins; Region: TTHB210-like; cd11669 1435356012305 oligomer interface [polypeptide binding]; other site 1435356012306 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1435356012307 Peptidase family M23; Region: Peptidase_M23; pfam01551 1435356012308 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1435356012309 Peptidase family M28; Region: Peptidase_M28; pfam04389 1435356012310 metal binding site [ion binding]; metal-binding site 1435356012311 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1435356012312 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1435356012313 heme-binding site [chemical binding]; other site 1435356012314 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1435356012315 FAD binding pocket [chemical binding]; other site 1435356012316 FAD binding motif [chemical binding]; other site 1435356012317 phosphate binding motif [ion binding]; other site 1435356012318 beta-alpha-beta structure motif; other site 1435356012319 NAD binding pocket [chemical binding]; other site 1435356012320 Heme binding pocket [chemical binding]; other site 1435356012321 Predicted transcriptional regulator [Transcription]; Region: COG1959 1435356012322 Transcriptional regulator; Region: Rrf2; cl17282 1435356012323 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1435356012324 Ligand Binding Site [chemical binding]; other site 1435356012325 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1435356012326 Ligand Binding Site [chemical binding]; other site 1435356012327 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1435356012328 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1435356012329 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1435356012330 Ligand Binding Site [chemical binding]; other site 1435356012331 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1435356012332 Ligand Binding Site [chemical binding]; other site 1435356012333 hypothetical protein; Provisional; Region: PRK14852 1435356012334 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1435356012335 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1435356012336 active site 1435356012337 phosphorylation site [posttranslational modification] 1435356012338 intermolecular recognition site; other site 1435356012339 dimerization interface [polypeptide binding]; other site 1435356012340 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1435356012341 DNA binding residues [nucleotide binding] 1435356012342 dimerization interface [polypeptide binding]; other site 1435356012343 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1435356012344 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1435356012345 GAF domain; Region: GAF_2; pfam13185 1435356012346 GAF domain; Region: GAF_3; pfam13492 1435356012347 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1435356012348 Histidine kinase; Region: HisKA_3; pfam07730 1435356012349 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1435356012350 ATP binding site [chemical binding]; other site 1435356012351 Mg2+ binding site [ion binding]; other site 1435356012352 G-X-G motif; other site 1435356012353 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 1435356012354 Predicted membrane protein (DUF2243); Region: DUF2243; cl01783 1435356012355 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1435356012356 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 1435356012357 gating phenylalanine in ion channel; other site 1435356012358 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1435356012359 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 1435356012360 putative DNA binding site [nucleotide binding]; other site 1435356012361 catalytic residue [active] 1435356012362 putative H2TH interface [polypeptide binding]; other site 1435356012363 putative catalytic residues [active] 1435356012364 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1435356012365 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1435356012366 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1435356012367 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1435356012368 dimerization interface [polypeptide binding]; other site 1435356012369 active site 1435356012370 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1435356012371 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1435356012372 folate binding site [chemical binding]; other site 1435356012373 NADP+ binding site [chemical binding]; other site 1435356012374 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1435356012375 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1435356012376 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1435356012377 substrate binding pocket [chemical binding]; other site 1435356012378 catalytic triad [active] 1435356012379 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356012380 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356012381 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1435356012382 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1435356012383 active site 1435356012384 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1435356012385 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1435356012386 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1435356012387 active site 1435356012388 dimer interface [polypeptide binding]; other site 1435356012389 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1435356012390 dimer interface [polypeptide binding]; other site 1435356012391 active site 1435356012392 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1435356012393 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1435356012394 tetramerization interface [polypeptide binding]; other site 1435356012395 NAD(P) binding site [chemical binding]; other site 1435356012396 catalytic residues [active] 1435356012397 hypothetical protein; Provisional; Region: PRK07857 1435356012398 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1435356012399 Part of AAA domain; Region: AAA_19; pfam13245 1435356012400 Family description; Region: UvrD_C_2; pfam13538 1435356012401 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1435356012402 Peptidase family M23; Region: Peptidase_M23; pfam01551 1435356012403 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1435356012404 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1435356012405 CoA-ligase; Region: Ligase_CoA; pfam00549 1435356012406 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1435356012407 CoA binding domain; Region: CoA_binding; smart00881 1435356012408 CoA-ligase; Region: Ligase_CoA; pfam00549 1435356012409 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1435356012410 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1435356012411 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1435356012412 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1435356012413 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1435356012414 active site 1435356012415 substrate binding site [chemical binding]; other site 1435356012416 cosubstrate binding site; other site 1435356012417 catalytic site [active] 1435356012418 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1435356012419 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1435356012420 purine monophosphate binding site [chemical binding]; other site 1435356012421 dimer interface [polypeptide binding]; other site 1435356012422 putative catalytic residues [active] 1435356012423 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1435356012424 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1435356012425 Fumarase C-terminus; Region: Fumerase_C; cl00795 1435356012426 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1435356012427 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1435356012428 nucleophilic elbow; other site 1435356012429 catalytic triad; other site 1435356012430 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 1435356012431 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 1435356012432 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1435356012433 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 1435356012434 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1435356012435 metal ion-dependent adhesion site (MIDAS); other site 1435356012436 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356012437 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1435356012438 Predicted permeases [General function prediction only]; Region: COG0679 1435356012439 30S ribosomal protein S18; Provisional; Region: PRK13401 1435356012440 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1435356012441 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1435356012442 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1435356012443 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1435356012444 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1435356012445 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1435356012446 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1435356012447 active site 1435356012448 phosphorylation site [posttranslational modification] 1435356012449 intermolecular recognition site; other site 1435356012450 dimerization interface [polypeptide binding]; other site 1435356012451 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1435356012452 DNA binding site [nucleotide binding] 1435356012453 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1435356012454 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1435356012455 dimerization interface [polypeptide binding]; other site 1435356012456 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1435356012457 dimer interface [polypeptide binding]; other site 1435356012458 phosphorylation site [posttranslational modification] 1435356012459 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1435356012460 ATP binding site [chemical binding]; other site 1435356012461 Mg2+ binding site [ion binding]; other site 1435356012462 G-X-G motif; other site 1435356012463 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1435356012464 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1435356012465 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1435356012466 MPT binding site; other site 1435356012467 trimer interface [polypeptide binding]; other site 1435356012468 MspA; Region: MspA; pfam09203 1435356012469 MspA; Region: MspA; pfam09203 1435356012470 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 1435356012471 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1435356012472 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1435356012473 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1435356012474 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 1435356012475 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1435356012476 active site 1435356012477 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1435356012478 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1435356012479 dimer interface [polypeptide binding]; other site 1435356012480 putative functional site; other site 1435356012481 putative MPT binding site; other site 1435356012482 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1435356012483 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1435356012484 short chain dehydrogenase; Provisional; Region: PRK07832 1435356012485 classical (c) SDRs; Region: SDR_c; cd05233 1435356012486 NAD(P) binding site [chemical binding]; other site 1435356012487 active site 1435356012488 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1435356012489 heme-binding site [chemical binding]; other site 1435356012490 arginine deiminase; Provisional; Region: PRK01388 1435356012491 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1435356012492 ArsC family; Region: ArsC; pfam03960 1435356012493 catalytic residues [active] 1435356012494 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1435356012495 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1435356012496 Predicted transcriptional regulators [Transcription]; Region: COG1725 1435356012497 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1435356012498 DNA-binding site [nucleotide binding]; DNA binding site 1435356012499 BCCT family transporter; Region: BCCT; pfam02028 1435356012500 protein-L-isoaspartate O-methyltransferase; Provisional; Region: PRK13942 1435356012501 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1435356012502 Predicted methyltransferases [General function prediction only]; Region: COG0313 1435356012503 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1435356012504 putative SAM binding site [chemical binding]; other site 1435356012505 putative homodimer interface [polypeptide binding]; other site 1435356012506 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1435356012507 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1435356012508 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1435356012509 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1435356012510 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1435356012511 structural tetrad; other site 1435356012512 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1435356012513 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1435356012514 structural tetrad; other site 1435356012515 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1435356012516 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 1435356012517 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1435356012518 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 1435356012519 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1435356012520 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1435356012521 DNA binding residues [nucleotide binding] 1435356012522 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1435356012523 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1435356012524 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 1435356012525 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 1435356012526 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1435356012527 active site 1435356012528 HIGH motif; other site 1435356012529 KMSKS motif; other site 1435356012530 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1435356012531 tRNA binding surface [nucleotide binding]; other site 1435356012532 anticodon binding site; other site 1435356012533 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1435356012534 active site 1435356012535 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1435356012536 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 1435356012537 active site 1435356012538 dimer interface [polypeptide binding]; other site 1435356012539 metal binding site [ion binding]; metal-binding site 1435356012540 Predicted membrane protein [Function unknown]; Region: COG2259 1435356012541 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1435356012542 Sulfatase; Region: Sulfatase; pfam00884 1435356012543 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1435356012544 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1435356012545 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1435356012546 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1435356012547 G5 domain; Region: G5; pfam07501 1435356012548 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1435356012549 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1435356012550 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1435356012551 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1435356012552 DNA-binding site [nucleotide binding]; DNA binding site 1435356012553 RNA-binding motif; other site 1435356012554 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 1435356012555 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1435356012556 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1435356012557 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1435356012558 ABC transporter; Region: ABC_tran_2; pfam12848 1435356012559 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1435356012560 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1435356012561 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1435356012562 enoyl-CoA hydratase; Provisional; Region: PRK06494 1435356012563 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1435356012564 substrate binding site [chemical binding]; other site 1435356012565 oxyanion hole (OAH) forming residues; other site 1435356012566 trimer interface [polypeptide binding]; other site 1435356012567 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 1435356012568 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1435356012569 active site 1435356012570 SnoaL-like domain; Region: SnoaL_4; pfam13577 1435356012571 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 1435356012572 putative dimer interface [polypeptide binding]; other site 1435356012573 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1435356012574 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 1435356012575 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1435356012576 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1435356012577 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1435356012578 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1435356012579 substrate binding site [chemical binding]; other site 1435356012580 oxyanion hole (OAH) forming residues; other site 1435356012581 trimer interface [polypeptide binding]; other site 1435356012582 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1435356012583 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 1435356012584 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1435356012585 G1 box; other site 1435356012586 putative GEF interaction site [polypeptide binding]; other site 1435356012587 GTP/Mg2+ binding site [chemical binding]; other site 1435356012588 Switch I region; other site 1435356012589 G2 box; other site 1435356012590 G3 box; other site 1435356012591 Switch II region; other site 1435356012592 G4 box; other site 1435356012593 G5 box; other site 1435356012594 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1435356012595 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 1435356012596 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1435356012597 acyl-activating enzyme (AAE) consensus motif; other site 1435356012598 AMP binding site [chemical binding]; other site 1435356012599 active site 1435356012600 CoA binding site [chemical binding]; other site 1435356012601 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1435356012602 putative active site [active] 1435356012603 catalytic residue [active] 1435356012604 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1435356012605 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1435356012606 5S rRNA interface [nucleotide binding]; other site 1435356012607 CTC domain interface [polypeptide binding]; other site 1435356012608 L16 interface [polypeptide binding]; other site 1435356012609 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1435356012610 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1435356012611 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1435356012612 catalytic residue [active] 1435356012613 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1435356012614 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 1435356012615 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1435356012616 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 1435356012617 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1435356012618 putative active site [active] 1435356012619 putative dimer interface [polypeptide binding]; other site 1435356012620 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 1435356012621 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 1435356012622 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1435356012623 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1435356012624 DNA binding residues [nucleotide binding] 1435356012625 dimerization interface [polypeptide binding]; other site 1435356012626 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 1435356012627 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1435356012628 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1435356012629 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1435356012630 active site 1435356012631 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 1435356012632 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1435356012633 Substrate binding site; other site 1435356012634 Mg++ binding site; other site 1435356012635 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1435356012636 active site 1435356012637 substrate binding site [chemical binding]; other site 1435356012638 CoA binding site [chemical binding]; other site 1435356012639 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356012640 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356012641 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356012642 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356012643 Helix-turn-helix domain; Region: HTH_17; pfam12728 1435356012644 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1435356012645 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1435356012646 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1435356012647 ATP binding site [chemical binding]; other site 1435356012648 putative Mg++ binding site [ion binding]; other site 1435356012649 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1435356012650 nucleotide binding region [chemical binding]; other site 1435356012651 ATP-binding site [chemical binding]; other site 1435356012652 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1435356012653 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1435356012654 homodimer interface [polypeptide binding]; other site 1435356012655 MazG family protein; Region: mazG; TIGR00444 1435356012656 metal binding site [ion binding]; metal-binding site 1435356012657 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1435356012658 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1435356012659 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1435356012660 DXD motif; other site 1435356012661 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1435356012662 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 1435356012663 NAD(P) binding site [chemical binding]; other site 1435356012664 active site 1435356012665 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1435356012666 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1435356012667 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1435356012668 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1435356012669 NAD(P) binding site [chemical binding]; other site 1435356012670 active site 1435356012671 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 1435356012672 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1435356012673 putative active site [active] 1435356012674 putative metal binding site [ion binding]; other site 1435356012675 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1435356012676 hypothetical protein; Provisional; Region: PRK07877 1435356012677 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 1435356012678 ATP binding site [chemical binding]; other site 1435356012679 substrate interface [chemical binding]; other site 1435356012680 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1435356012681 FMN binding site [chemical binding]; other site 1435356012682 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1435356012683 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1435356012684 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1435356012685 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1435356012686 metal binding site [ion binding]; metal-binding site 1435356012687 active site 1435356012688 I-site; other site 1435356012689 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1435356012690 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 1435356012691 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1435356012692 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1435356012693 enolase; Provisional; Region: eno; PRK00077 1435356012694 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1435356012695 dimer interface [polypeptide binding]; other site 1435356012696 metal binding site [ion binding]; metal-binding site 1435356012697 substrate binding pocket [chemical binding]; other site 1435356012698 Septum formation initiator; Region: DivIC; cl17659 1435356012699 Uncharacterized conserved protein [Function unknown]; Region: COG1507 1435356012700 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1435356012701 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1435356012702 Secretory lipase; Region: LIP; pfam03583 1435356012703 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1435356012704 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1435356012705 Walker A/P-loop; other site 1435356012706 ATP binding site [chemical binding]; other site 1435356012707 Q-loop/lid; other site 1435356012708 ABC transporter signature motif; other site 1435356012709 Walker B; other site 1435356012710 D-loop; other site 1435356012711 H-loop/switch region; other site 1435356012712 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1435356012713 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1435356012714 dimer interface [polypeptide binding]; other site 1435356012715 conserved gate region; other site 1435356012716 putative PBP binding loops; other site 1435356012717 ABC-ATPase subunit interface; other site 1435356012718 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1435356012719 NMT1/THI5 like; Region: NMT1; pfam09084 1435356012720 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1435356012721 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 1435356012722 oligomer interface [polypeptide binding]; other site 1435356012723 metal binding site [ion binding]; metal-binding site 1435356012724 metal binding site [ion binding]; metal-binding site 1435356012725 putative Cl binding site [ion binding]; other site 1435356012726 aspartate ring; other site 1435356012727 basic sphincter; other site 1435356012728 hydrophobic gate; other site 1435356012729 periplasmic entrance; other site 1435356012730 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1435356012731 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1435356012732 active site 1435356012733 ATP binding site [chemical binding]; other site 1435356012734 substrate binding site [chemical binding]; other site 1435356012735 activation loop (A-loop); other site 1435356012736 AAA ATPase domain; Region: AAA_16; pfam13191 1435356012737 AAA domain; Region: AAA_22; pfam13401 1435356012738 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1435356012739 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1435356012740 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1435356012741 S-adenosylmethionine binding site [chemical binding]; other site 1435356012742 Bax inhibitor 1 like; Region: BaxI_1; cl17691 1435356012743 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 1435356012744 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1435356012745 dimer interface [polypeptide binding]; other site 1435356012746 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1435356012747 catalytic residue [active] 1435356012748 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 1435356012749 cystathionine gamma-synthase; Provisional; Region: PRK07811 1435356012750 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1435356012751 homodimer interface [polypeptide binding]; other site 1435356012752 substrate-cofactor binding pocket; other site 1435356012753 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1435356012754 catalytic residue [active] 1435356012755 SEC-C motif; Region: SEC-C; pfam02810 1435356012756 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1435356012757 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1435356012758 catalytic residue [active] 1435356012759 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1435356012760 NlpC/P60 family; Region: NLPC_P60; pfam00877 1435356012761 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1435356012762 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1435356012763 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1435356012764 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 1435356012765 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 1435356012766 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1435356012767 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1435356012768 catalytic residues [active] 1435356012769 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1435356012770 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1435356012771 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1435356012772 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1435356012773 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1435356012774 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1435356012775 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1435356012776 catalytic residue [active] 1435356012777 putative FPP diphosphate binding site; other site 1435356012778 putative FPP binding hydrophobic cleft; other site 1435356012779 dimer interface [polypeptide binding]; other site 1435356012780 putative IPP diphosphate binding site; other site 1435356012781 pantothenate kinase; Provisional; Region: PRK05439 1435356012782 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1435356012783 ATP-binding site [chemical binding]; other site 1435356012784 CoA-binding site [chemical binding]; other site 1435356012785 Mg2+-binding site [ion binding]; other site 1435356012786 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1435356012787 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1435356012788 dimer interface [polypeptide binding]; other site 1435356012789 active site 1435356012790 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1435356012791 folate binding site [chemical binding]; other site 1435356012792 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1435356012793 Isochorismatase family; Region: Isochorismatase; pfam00857 1435356012794 catalytic triad [active] 1435356012795 conserved cis-peptide bond; other site 1435356012796 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1435356012797 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1435356012798 putative active site [active] 1435356012799 PhoH-like protein; Region: PhoH; pfam02562 1435356012800 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1435356012801 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1435356012802 LGFP repeat; Region: LGFP; pfam08310 1435356012803 LGFP repeat; Region: LGFP; pfam08310 1435356012804 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1435356012805 Class II fumarases; Region: Fumarase_classII; cd01362 1435356012806 active site 1435356012807 tetramer interface [polypeptide binding]; other site 1435356012808 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1435356012809 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1435356012810 putative active site [active] 1435356012811 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 1435356012812 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1435356012813 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1435356012814 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1435356012815 generic binding surface II; other site 1435356012816 generic binding surface I; other site 1435356012817 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1435356012818 oxyanion hole (OAH) forming residues; other site 1435356012819 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1435356012820 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1435356012821 RmuC family; Region: RmuC; pfam02646 1435356012822 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1435356012823 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1435356012824 active site 1435356012825 metal binding site [ion binding]; metal-binding site 1435356012826 DNA binding site [nucleotide binding] 1435356012827 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1435356012828 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1435356012829 Walker A/P-loop; other site 1435356012830 ATP binding site [chemical binding]; other site 1435356012831 Q-loop/lid; other site 1435356012832 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1435356012833 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1435356012834 ABC transporter signature motif; other site 1435356012835 Walker B; other site 1435356012836 D-loop; other site 1435356012837 H-loop/switch region; other site 1435356012838 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1435356012839 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1435356012840 GTP-binding protein YchF; Reviewed; Region: PRK09601 1435356012841 YchF GTPase; Region: YchF; cd01900 1435356012842 G1 box; other site 1435356012843 GTP/Mg2+ binding site [chemical binding]; other site 1435356012844 Switch I region; other site 1435356012845 G2 box; other site 1435356012846 Switch II region; other site 1435356012847 G3 box; other site 1435356012848 G4 box; other site 1435356012849 G5 box; other site 1435356012850 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1435356012851 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1435356012852 Condensation domain; Region: Condensation; pfam00668 1435356012853 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1435356012854 Coenzyme A binding pocket [chemical binding]; other site 1435356012855 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1435356012856 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1435356012857 active site 1435356012858 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356012859 siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718 1435356012860 putative substrate translocation pore; other site 1435356012861 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1435356012862 non-specific DNA binding site [nucleotide binding]; other site 1435356012863 salt bridge; other site 1435356012864 sequence-specific DNA binding site [nucleotide binding]; other site 1435356012865 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1435356012866 active site 1435356012867 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 1435356012868 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 1435356012869 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1435356012870 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1435356012871 sequence-specific DNA binding site [nucleotide binding]; other site 1435356012872 salt bridge; other site 1435356012873 Cupin domain; Region: Cupin_2; pfam07883 1435356012874 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1435356012875 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1435356012876 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1435356012877 NAD-dependent benzaldehyde dehydrogenase II-like; Region: ALDH_BenzADH; cd07152 1435356012878 NAD(P) binding site [chemical binding]; other site 1435356012879 catalytic residues [active] 1435356012880 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1435356012881 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1435356012882 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1435356012883 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1435356012884 potential catalytic triad [active] 1435356012885 conserved cys residue [active] 1435356012886 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1435356012887 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 1435356012888 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 1435356012889 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1435356012890 Part of AAA domain; Region: AAA_19; pfam13245 1435356012891 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1435356012892 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 1435356012893 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 1435356012894 AAA domain; Region: AAA_30; pfam13604 1435356012895 Family description; Region: UvrD_C_2; pfam13538 1435356012896 Lipase maturation factor; Region: LMF1; pfam06762 1435356012897 maltose O-acetyltransferase; Provisional; Region: PRK10092 1435356012898 Maltose acetyltransferase; Region: Mac; pfam12464 1435356012899 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1435356012900 trimer interface [polypeptide binding]; other site 1435356012901 active site 1435356012902 substrate binding site [chemical binding]; other site 1435356012903 CoA binding site [chemical binding]; other site 1435356012904 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1435356012905 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1435356012906 Walker A/P-loop; other site 1435356012907 ATP binding site [chemical binding]; other site 1435356012908 Q-loop/lid; other site 1435356012909 ABC transporter signature motif; other site 1435356012910 Walker B; other site 1435356012911 D-loop; other site 1435356012912 H-loop/switch region; other site 1435356012913 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1435356012914 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1435356012915 dimer interface [polypeptide binding]; other site 1435356012916 conserved gate region; other site 1435356012917 putative PBP binding loops; other site 1435356012918 ABC-ATPase subunit interface; other site 1435356012919 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1435356012920 dimer interface [polypeptide binding]; other site 1435356012921 conserved gate region; other site 1435356012922 putative PBP binding loops; other site 1435356012923 ABC-ATPase subunit interface; other site 1435356012924 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1435356012925 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1435356012926 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1435356012927 DNA binding residues [nucleotide binding] 1435356012928 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1435356012929 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1435356012930 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1435356012931 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 1435356012932 inhibitor binding site; inhibition site 1435356012933 catalytic Zn binding site [ion binding]; other site 1435356012934 structural Zn binding site [ion binding]; other site 1435356012935 NADP binding site [chemical binding]; other site 1435356012936 tetramer interface [polypeptide binding]; other site 1435356012937 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1435356012938 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1435356012939 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1435356012940 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1435356012941 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1435356012942 putative substrate binding site [chemical binding]; other site 1435356012943 putative ATP binding site [chemical binding]; other site 1435356012944 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1435356012945 D-xylulose kinase; Region: XylB; TIGR01312 1435356012946 nucleotide binding site [chemical binding]; other site 1435356012947 CGNR zinc finger; Region: zf-CGNR; pfam11706 1435356012948 polynucleotide kinase; Provisional; Region: pseT; PHA02530 1435356012949 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1435356012950 AAA ATPase domain; Region: AAA_16; pfam13191 1435356012951 Walker A motif; other site 1435356012952 ATP binding site [chemical binding]; other site 1435356012953 Walker B motif; other site 1435356012954 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1435356012955 nucleotide binding site [chemical binding]; other site 1435356012956 DDE superfamily endonuclease; Region: DDE_5; pfam13546 1435356012957 DDE superfamily endonuclease; Region: DDE_4; pfam13359 1435356012958 Predicted helicase [General function prediction only]; Region: COG4889 1435356012959 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1435356012960 Helix-turn-helix domain; Region: HTH_38; pfam13936 1435356012961 Integrase core domain; Region: rve; pfam00665 1435356012962 transposase/IS protein; Provisional; Region: PRK09183 1435356012963 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1435356012964 Walker A motif; other site 1435356012965 ATP binding site [chemical binding]; other site 1435356012966 Walker B motif; other site 1435356012967 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1435356012968 DNA-binding site [nucleotide binding]; DNA binding site 1435356012969 RNA-binding motif; other site 1435356012970 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 1435356012971 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1435356012972 Walker A/P-loop; other site 1435356012973 ATP binding site [chemical binding]; other site 1435356012974 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 1435356012975 active site 1435356012976 metal binding site [ion binding]; metal-binding site 1435356012977 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 1435356012978 3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074 1435356012979 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1435356012980 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1435356012981 Bacterial transcriptional regulator; Region: IclR; pfam01614 1435356012982 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1435356012983 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356012984 putative substrate translocation pore; other site 1435356012985 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1435356012986 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1435356012987 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1435356012988 active site 2 [active] 1435356012989 active site 1 [active] 1435356012990 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1435356012991 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1435356012992 iron-sulfur cluster [ion binding]; other site 1435356012993 [2Fe-2S] cluster binding site [ion binding]; other site 1435356012994 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1435356012995 hydrophobic ligand binding site; other site 1435356012996 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1435356012997 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 1435356012998 metal binding site [ion binding]; metal-binding site 1435356012999 Subunit B of the Class III Extradiol dioxygenase, Protocatechuate 4,5-dioxygenase, and simlar enzymes; Region: PCA_45_Doxase_B_like; cd07359 1435356013000 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1435356013001 active site 1435356013002 Fe(II) binding site [ion binding]; other site 1435356013003 dimer interface [polypeptide binding]; other site 1435356013004 tetramer interface [polypeptide binding]; other site 1435356013005 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1435356013006 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1435356013007 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_11; cd12175 1435356013008 putative ligand binding site [chemical binding]; other site 1435356013009 putative NAD binding site [chemical binding]; other site 1435356013010 catalytic site [active] 1435356013011 NMT1-like family; Region: NMT1_2; pfam13379 1435356013012 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1435356013013 substrate binding pocket [chemical binding]; other site 1435356013014 membrane-bound complex binding site; other site 1435356013015 hinge residues; other site 1435356013016 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1435356013017 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1435356013018 Walker A/P-loop; other site 1435356013019 ATP binding site [chemical binding]; other site 1435356013020 Q-loop/lid; other site 1435356013021 ABC transporter signature motif; other site 1435356013022 Walker B; other site 1435356013023 D-loop; other site 1435356013024 H-loop/switch region; other site 1435356013025 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1435356013026 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1435356013027 dimer interface [polypeptide binding]; other site 1435356013028 conserved gate region; other site 1435356013029 putative PBP binding loops; other site 1435356013030 ABC-ATPase subunit interface; other site 1435356013031 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1435356013032 intersubunit interface [polypeptide binding]; other site 1435356013033 active site 1435356013034 Zn2+ binding site [ion binding]; other site 1435356013035 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1435356013036 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1435356013037 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1435356013038 Ferredoxin [Energy production and conversion]; Region: COG1146 1435356013039 4Fe-4S binding domain; Region: Fer4; pfam00037 1435356013040 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1435356013041 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1435356013042 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1435356013043 Bacterial transcriptional regulator; Region: IclR; pfam01614 1435356013044 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 1435356013045 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 1435356013046 acyl-activating enzyme (AAE) consensus motif; other site 1435356013047 putative AMP binding site [chemical binding]; other site 1435356013048 putative active site [active] 1435356013049 putative CoA binding site [chemical binding]; other site 1435356013050 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1435356013051 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1435356013052 putative NAD(P) binding site [chemical binding]; other site 1435356013053 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1435356013054 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1435356013055 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1435356013056 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1435356013057 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1435356013058 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1435356013059 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1435356013060 NMT1-like family; Region: NMT1_2; pfam13379 1435356013061 NMT1/THI5 like; Region: NMT1; pfam09084 1435356013062 enoyl-CoA hydratase; Provisional; Region: PRK06688 1435356013063 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1435356013064 substrate binding site [chemical binding]; other site 1435356013065 oxyanion hole (OAH) forming residues; other site 1435356013066 trimer interface [polypeptide binding]; other site 1435356013067 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1435356013068 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 1435356013069 RNAase interaction site [polypeptide binding]; other site 1435356013070 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1435356013071 RNA-binding motif; other site 1435356013072 DNA-binding site [nucleotide binding]; DNA binding site 1435356013073 Protein of unknown function (DUF2716); Region: DUF2716; pfam10898 1435356013074 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1435356013075 dimer interface [polypeptide binding]; other site 1435356013076 benzoate transport; Region: 2A0115; TIGR00895 1435356013077 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356013078 putative substrate translocation pore; other site 1435356013079 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356013080 acyl-CoA synthetase; Validated; Region: PRK08162 1435356013081 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 1435356013082 acyl-activating enzyme (AAE) consensus motif; other site 1435356013083 putative active site [active] 1435356013084 AMP binding site [chemical binding]; other site 1435356013085 putative CoA binding site [chemical binding]; other site 1435356013086 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1435356013087 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1435356013088 oligomer interface [polypeptide binding]; other site 1435356013089 active site residues [active] 1435356013090 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1435356013091 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1435356013092 oligomer interface [polypeptide binding]; other site 1435356013093 active site residues [active] 1435356013094 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1435356013095 non-specific DNA binding site [nucleotide binding]; other site 1435356013096 salt bridge; other site 1435356013097 sequence-specific DNA binding site [nucleotide binding]; other site 1435356013098 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1435356013099 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 1435356013100 allantoinase; Region: allantoinase; TIGR03178 1435356013101 active site 1435356013102 allantoicase; Provisional; Region: PRK13257 1435356013103 Allantoicase repeat; Region: Allantoicase; pfam03561 1435356013104 Allantoicase repeat; Region: Allantoicase; pfam03561 1435356013105 xanthine permease; Region: pbuX; TIGR03173 1435356013106 oxidase reductase; Provisional; Region: PTZ00273 1435356013107 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1435356013108 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1435356013109 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1435356013110 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1435356013111 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1435356013112 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1435356013113 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1435356013114 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1435356013115 TM-ABC transporter signature motif; other site 1435356013116 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1435356013117 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1435356013118 TM-ABC transporter signature motif; other site 1435356013119 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1435356013120 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1435356013121 Walker A/P-loop; other site 1435356013122 ATP binding site [chemical binding]; other site 1435356013123 Q-loop/lid; other site 1435356013124 ABC transporter signature motif; other site 1435356013125 Walker B; other site 1435356013126 D-loop; other site 1435356013127 H-loop/switch region; other site 1435356013128 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1435356013129 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1435356013130 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1435356013131 non-specific DNA binding site [nucleotide binding]; other site 1435356013132 salt bridge; other site 1435356013133 sequence-specific DNA binding site [nucleotide binding]; other site 1435356013134 Cupin domain; Region: Cupin_2; cl17218 1435356013135 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 1435356013136 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1435356013137 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1435356013138 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1435356013139 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1435356013140 NAD(P) binding site [chemical binding]; other site 1435356013141 catalytic residues [active] 1435356013142 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1435356013143 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1435356013144 hydrophobic ligand binding site; other site 1435356013145 choline dehydrogenase; Validated; Region: PRK02106 1435356013146 lycopene cyclase; Region: lycopene_cycl; TIGR01789 1435356013147 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1435356013148 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1435356013149 TPP-binding site [chemical binding]; other site 1435356013150 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1435356013151 PYR/PP interface [polypeptide binding]; other site 1435356013152 dimer interface [polypeptide binding]; other site 1435356013153 TPP binding site [chemical binding]; other site 1435356013154 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1435356013155 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1435356013156 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1435356013157 N-terminal domain interface [polypeptide binding]; other site 1435356013158 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1435356013159 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1435356013160 [2Fe-2S] cluster binding site [ion binding]; other site 1435356013161 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1435356013162 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1435356013163 catalytic loop [active] 1435356013164 iron binding site [ion binding]; other site 1435356013165 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1435356013166 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1435356013167 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1435356013168 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1435356013169 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1435356013170 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 1435356013171 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1435356013172 active site 1435356013173 putative substrate binding pocket [chemical binding]; other site 1435356013174 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1435356013175 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1435356013176 urate oxidase; Region: urate_oxi; TIGR03383 1435356013177 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1435356013178 active site 1435356013179 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1435356013180 active site 1435356013181 homotetramer interface [polypeptide binding]; other site 1435356013182 putative OHCU decarboxylase; Provisional; Region: PRK13798 1435356013183 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1435356013184 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1435356013185 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1435356013186 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1435356013187 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1435356013188 fumarate hydratase; Provisional; Region: PRK15389 1435356013189 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 1435356013190 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1435356013191 CAAX protease self-immunity; Region: Abi; pfam02517 1435356013192 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1435356013193 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1435356013194 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1435356013195 non-specific DNA binding site [nucleotide binding]; other site 1435356013196 salt bridge; other site 1435356013197 sequence-specific DNA binding site [nucleotide binding]; other site 1435356013198 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 1435356013199 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 1435356013200 active site 1435356013201 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1435356013202 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1435356013203 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 1435356013204 Mrr N-terminal domain; Region: Mrr_N; pfam14338 1435356013205 Restriction endonuclease; Region: Mrr_cat; pfam04471 1435356013206 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 1435356013207 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1435356013208 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356013209 mannosyltransferase; Provisional; Region: pimE; PRK13375 1435356013210 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1435356013211 aromatic arch; other site 1435356013212 DCoH dimer interaction site [polypeptide binding]; other site 1435356013213 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1435356013214 DCoH tetramer interaction site [polypeptide binding]; other site 1435356013215 substrate binding site [chemical binding]; other site 1435356013216 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1435356013217 active site 1435356013218 8-oxo-dGMP binding site [chemical binding]; other site 1435356013219 nudix motif; other site 1435356013220 metal binding site [ion binding]; metal-binding site 1435356013221 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1435356013222 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1435356013223 G1 box; other site 1435356013224 putative GEF interaction site [polypeptide binding]; other site 1435356013225 GTP/Mg2+ binding site [chemical binding]; other site 1435356013226 Switch I region; other site 1435356013227 G2 box; other site 1435356013228 G3 box; other site 1435356013229 Switch II region; other site 1435356013230 G4 box; other site 1435356013231 G5 box; other site 1435356013232 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1435356013233 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1435356013234 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1435356013235 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1435356013236 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1435356013237 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 1435356013238 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 1435356013239 Fe-S cluster binding site [ion binding]; other site 1435356013240 DNA binding site [nucleotide binding] 1435356013241 active site 1435356013242 Predicted membrane protein [Function unknown]; Region: COG3428 1435356013243 Bacterial PH domain; Region: DUF304; pfam03703 1435356013244 Bacterial PH domain; Region: DUF304; cl01348 1435356013245 FO synthase; Reviewed; Region: fbiC; PRK09234 1435356013246 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1435356013247 FeS/SAM binding site; other site 1435356013248 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1435356013249 FeS/SAM binding site; other site 1435356013250 Ferredoxin [Energy production and conversion]; Region: COG1146 1435356013251 4Fe-4S binding domain; Region: Fer4; pfam00037 1435356013252 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 1435356013253 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1435356013254 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1435356013255 homodimer interface [polypeptide binding]; other site 1435356013256 catalytic residue [active] 1435356013257 acyl-CoA synthetase; Validated; Region: PRK07787 1435356013258 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1435356013259 acyl-activating enzyme (AAE) consensus motif; other site 1435356013260 AMP binding site [chemical binding]; other site 1435356013261 active site 1435356013262 CoA binding site [chemical binding]; other site 1435356013263 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1435356013264 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1435356013265 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1435356013266 metal ion-dependent adhesion site (MIDAS); other site 1435356013267 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1435356013268 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1435356013269 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1435356013270 putative trimer interface [polypeptide binding]; other site 1435356013271 putative CoA binding site [chemical binding]; other site 1435356013272 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 1435356013273 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 1435356013274 metal binding site [ion binding]; metal-binding site 1435356013275 putative dimer interface [polypeptide binding]; other site 1435356013276 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1435356013277 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1435356013278 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 1435356013279 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 1435356013280 acyl-activating enzyme (AAE) consensus motif; other site 1435356013281 putative AMP binding site [chemical binding]; other site 1435356013282 putative active site [active] 1435356013283 putative CoA binding site [chemical binding]; other site 1435356013284 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1435356013285 dihydropteroate synthase; Region: DHPS; TIGR01496 1435356013286 substrate binding pocket [chemical binding]; other site 1435356013287 dimer interface [polypeptide binding]; other site 1435356013288 inhibitor binding site; inhibition site 1435356013289 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 1435356013290 DivIVA domain; Region: DivI1A_domain; TIGR03544 1435356013291 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1435356013292 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 1435356013293 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1435356013294 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1435356013295 S-adenosylmethionine binding site [chemical binding]; other site 1435356013296 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1435356013297 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1435356013298 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 1435356013299 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1435356013300 ligand binding site; other site 1435356013301 oligomer interface; other site 1435356013302 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1435356013303 dimer interface [polypeptide binding]; other site 1435356013304 N-terminal domain interface [polypeptide binding]; other site 1435356013305 sulfate 1 binding site; other site 1435356013306 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1435356013307 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1435356013308 S-adenosylmethionine binding site [chemical binding]; other site 1435356013309 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1435356013310 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1435356013311 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1435356013312 DNA binding residues [nucleotide binding] 1435356013313 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1435356013314 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1435356013315 protein binding site [polypeptide binding]; other site 1435356013316 sec-independent translocase; Provisional; Region: PRK03100 1435356013317 Domain of unknown function DUF59; Region: DUF59; cl00941 1435356013318 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1435356013319 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1435356013320 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 1435356013321 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1435356013322 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1435356013323 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 1435356013324 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 1435356013325 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1435356013326 MgtE intracellular N domain; Region: MgtE_N; smart00924 1435356013327 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1435356013328 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1435356013329 hypothetical protein; Provisional; Region: PRK01346 1435356013330 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 1435356013331 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1435356013332 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1435356013333 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1435356013334 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1435356013335 dimer interface [polypeptide binding]; other site 1435356013336 conserved gate region; other site 1435356013337 putative PBP binding loops; other site 1435356013338 ABC-ATPase subunit interface; other site 1435356013339 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1435356013340 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1435356013341 dimer interface [polypeptide binding]; other site 1435356013342 conserved gate region; other site 1435356013343 putative PBP binding loops; other site 1435356013344 ABC-ATPase subunit interface; other site 1435356013345 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1435356013346 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1435356013347 Walker A/P-loop; other site 1435356013348 ATP binding site [chemical binding]; other site 1435356013349 Q-loop/lid; other site 1435356013350 ABC transporter signature motif; other site 1435356013351 Walker B; other site 1435356013352 D-loop; other site 1435356013353 H-loop/switch region; other site 1435356013354 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 1435356013355 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1435356013356 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1435356013357 oligomer interface [polypeptide binding]; other site 1435356013358 metal binding site [ion binding]; metal-binding site 1435356013359 metal binding site [ion binding]; metal-binding site 1435356013360 putative Cl binding site [ion binding]; other site 1435356013361 basic sphincter; other site 1435356013362 hydrophobic gate; other site 1435356013363 periplasmic entrance; other site 1435356013364 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1435356013365 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 1435356013366 active site 1435356013367 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1435356013368 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1435356013369 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1435356013370 putative NAD(P) binding site [chemical binding]; other site 1435356013371 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1435356013372 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1435356013373 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1435356013374 NAD(P) binding site [chemical binding]; other site 1435356013375 active site 1435356013376 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1435356013377 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1435356013378 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356013379 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356013380 thiamine pyrophosphate protein; Provisional; Region: PRK08273 1435356013381 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1435356013382 PYR/PP interface [polypeptide binding]; other site 1435356013383 dimer interface [polypeptide binding]; other site 1435356013384 tetramer interface [polypeptide binding]; other site 1435356013385 TPP binding site [chemical binding]; other site 1435356013386 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1435356013387 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1435356013388 TPP-binding site [chemical binding]; other site 1435356013389 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 1435356013390 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1435356013391 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1435356013392 TPP-binding site [chemical binding]; other site 1435356013393 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1435356013394 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1435356013395 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1435356013396 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1435356013397 Walker A/P-loop; other site 1435356013398 ATP binding site [chemical binding]; other site 1435356013399 Q-loop/lid; other site 1435356013400 ABC transporter signature motif; other site 1435356013401 Walker B; other site 1435356013402 D-loop; other site 1435356013403 H-loop/switch region; other site 1435356013404 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1435356013405 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1435356013406 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1435356013407 Walker A/P-loop; other site 1435356013408 ATP binding site [chemical binding]; other site 1435356013409 Q-loop/lid; other site 1435356013410 ABC transporter signature motif; other site 1435356013411 Walker B; other site 1435356013412 D-loop; other site 1435356013413 H-loop/switch region; other site 1435356013414 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1435356013415 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1435356013416 Walker A/P-loop; other site 1435356013417 ATP binding site [chemical binding]; other site 1435356013418 Q-loop/lid; other site 1435356013419 ABC transporter signature motif; other site 1435356013420 Walker B; other site 1435356013421 D-loop; other site 1435356013422 H-loop/switch region; other site 1435356013423 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1435356013424 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1435356013425 Helix-turn-helix domain; Region: HTH_18; pfam12833 1435356013426 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1435356013427 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 1435356013428 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1435356013429 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1435356013430 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1435356013431 putative dimer interface [polypeptide binding]; other site 1435356013432 N-terminal domain interface [polypeptide binding]; other site 1435356013433 putative substrate binding pocket (H-site) [chemical binding]; other site 1435356013434 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356013435 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1435356013436 putative substrate translocation pore; other site 1435356013437 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356013438 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1435356013439 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1435356013440 acyl-activating enzyme (AAE) consensus motif; other site 1435356013441 AMP binding site [chemical binding]; other site 1435356013442 enoyl-CoA hydratase; Provisional; Region: PRK08252 1435356013443 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1435356013444 substrate binding site [chemical binding]; other site 1435356013445 oxyanion hole (OAH) forming residues; other site 1435356013446 trimer interface [polypeptide binding]; other site 1435356013447 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1435356013448 adenosine deaminase; Provisional; Region: PRK09358 1435356013449 active site 1435356013450 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 1435356013451 FAD binding domain; Region: FAD_binding_4; pfam01565 1435356013452 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1435356013453 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1435356013454 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 1435356013455 dimer interface [polypeptide binding]; other site 1435356013456 active site 1435356013457 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1435356013458 substrate binding site [chemical binding]; other site 1435356013459 catalytic residue [active] 1435356013460 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1435356013461 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1435356013462 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1435356013463 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1435356013464 acyl-activating enzyme (AAE) consensus motif; other site 1435356013465 putative AMP binding site [chemical binding]; other site 1435356013466 putative active site [active] 1435356013467 putative CoA binding site [chemical binding]; other site 1435356013468 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 1435356013469 tryptophan synthase subunit beta; Reviewed; Region: PRK12391 1435356013470 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1435356013471 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1435356013472 catalytic residue [active] 1435356013473 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1435356013474 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1435356013475 ATP binding site [chemical binding]; other site 1435356013476 Mg++ binding site [ion binding]; other site 1435356013477 motif III; other site 1435356013478 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1435356013479 nucleotide binding region [chemical binding]; other site 1435356013480 ATP-binding site [chemical binding]; other site 1435356013481 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1435356013482 putative RNA binding site [nucleotide binding]; other site 1435356013483 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1435356013484 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1435356013485 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1435356013486 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1435356013487 Walker A/P-loop; other site 1435356013488 ATP binding site [chemical binding]; other site 1435356013489 Q-loop/lid; other site 1435356013490 ABC transporter signature motif; other site 1435356013491 Walker B; other site 1435356013492 D-loop; other site 1435356013493 H-loop/switch region; other site 1435356013494 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1435356013495 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1435356013496 Walker A/P-loop; other site 1435356013497 ATP binding site [chemical binding]; other site 1435356013498 Q-loop/lid; other site 1435356013499 ABC transporter signature motif; other site 1435356013500 Walker B; other site 1435356013501 D-loop; other site 1435356013502 H-loop/switch region; other site 1435356013503 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1435356013504 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1435356013505 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1435356013506 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356013507 endonuclease IV; Provisional; Region: PRK01060 1435356013508 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1435356013509 AP (apurinic/apyrimidinic) site pocket; other site 1435356013510 DNA interaction; other site 1435356013511 Metal-binding active site; metal-binding site 1435356013512 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1435356013513 classical (c) SDRs; Region: SDR_c; cd05233 1435356013514 NAD(P) binding site [chemical binding]; other site 1435356013515 active site 1435356013516 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1435356013517 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1435356013518 Walker A/P-loop; other site 1435356013519 ATP binding site [chemical binding]; other site 1435356013520 Q-loop/lid; other site 1435356013521 ABC transporter signature motif; other site 1435356013522 Walker B; other site 1435356013523 D-loop; other site 1435356013524 H-loop/switch region; other site 1435356013525 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1435356013526 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1435356013527 FtsX-like permease family; Region: FtsX; pfam02687 1435356013528 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1435356013529 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1435356013530 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1435356013531 active site 1435356013532 catalytic residues [active] 1435356013533 metal binding site [ion binding]; metal-binding site 1435356013534 Predicted transcriptional regulators [Transcription]; Region: COG1695 1435356013535 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1435356013536 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1435356013537 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1435356013538 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1435356013539 NAD(P) binding site [chemical binding]; other site 1435356013540 putative active site [active] 1435356013541 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1435356013542 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1435356013543 Hypothetical protein TTHB210, a sigma(E)-regulated gene product found in Thermus thermophilus, and similar proteins; Region: TTHB210-like; cd11669 1435356013544 oligomer interface [polypeptide binding]; other site 1435356013545 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1435356013546 hydrophobic ligand binding site; other site 1435356013547 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1435356013548 homodimer interface [polypeptide binding]; other site 1435356013549 active site 1435356013550 TDP-binding site; other site 1435356013551 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1435356013552 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1435356013553 DNA binding residues [nucleotide binding] 1435356013554 dimerization interface [polypeptide binding]; other site 1435356013555 salicylate hydroxylase; Provisional; Region: PRK08163 1435356013556 Excalibur calcium-binding domain; Region: Excalibur; smart00894 1435356013557 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 1435356013558 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1435356013559 dimer interface [polypeptide binding]; other site 1435356013560 active site 1435356013561 CoA binding pocket [chemical binding]; other site 1435356013562 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1435356013563 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1435356013564 NAD(P) binding site [chemical binding]; other site 1435356013565 homotetramer interface [polypeptide binding]; other site 1435356013566 homodimer interface [polypeptide binding]; other site 1435356013567 active site 1435356013568 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1435356013569 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1435356013570 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1435356013571 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1435356013572 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1435356013573 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1435356013574 carboxyltransferase (CT) interaction site; other site 1435356013575 biotinylation site [posttranslational modification]; other site 1435356013576 Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326 1435356013577 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1435356013578 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 1435356013579 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1435356013580 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1435356013581 Magnesium ion binding site [ion binding]; other site 1435356013582 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1435356013583 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1435356013584 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1435356013585 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1435356013586 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1435356013587 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1435356013588 D-pathway; other site 1435356013589 Putative ubiquinol binding site [chemical binding]; other site 1435356013590 Low-spin heme (heme b) binding site [chemical binding]; other site 1435356013591 Putative water exit pathway; other site 1435356013592 Binuclear center (heme o3/CuB) [ion binding]; other site 1435356013593 K-pathway; other site 1435356013594 Putative proton exit pathway; other site 1435356013595 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1435356013596 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1435356013597 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 1435356013598 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1435356013599 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1435356013600 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 1435356013601 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 1435356013602 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1435356013603 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1435356013604 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 1435356013605 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1435356013606 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1435356013607 Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Region: SLC5sbd_CHT; cd11474 1435356013608 Na binding site [ion binding]; other site 1435356013609 putative glycosylation site [posttranslational modification]; other site 1435356013610 putative glycosylation site [posttranslational modification]; other site 1435356013611 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1435356013612 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1435356013613 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1435356013614 hexamer interface [polypeptide binding]; other site 1435356013615 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1435356013616 active site 1435356013617 metal binding site [ion binding]; metal-binding site 1435356013618 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 1435356013619 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642 1435356013620 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1435356013621 NAD(P) binding site [chemical binding]; other site 1435356013622 active site 1435356013623 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1435356013624 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1435356013625 active site 1435356013626 non-prolyl cis peptide bond; other site 1435356013627 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1435356013628 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1435356013629 Beta-lactamase; Region: Beta-lactamase; pfam00144 1435356013630 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1435356013631 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1435356013632 NAD(P) binding site [chemical binding]; other site 1435356013633 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1435356013634 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1435356013635 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1435356013636 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1435356013637 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 1435356013638 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1435356013639 active site 1435356013640 catalytic site [active] 1435356013641 substrate binding site [chemical binding]; other site 1435356013642 BRCA1 C Terminus (BRCT) domain; Region: BRCT; pfam00533 1435356013643 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1435356013644 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1435356013645 putative metal binding site [ion binding]; other site 1435356013646 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1435356013647 aminopeptidase N; Provisional; Region: pepN; PRK14015 1435356013648 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1435356013649 Pescadillo N-terminus; Region: Pescadillo_N; pfam06732 1435356013650 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1435356013651 Protein required for biogenesis of the 60S ribosomal subunit [Translation, ribosomal structure and biogenesis]; Region: NOP7; COG5163 1435356013652 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1435356013653 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1435356013654 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1435356013655 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356013656 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1435356013657 aconitate hydratase; Validated; Region: PRK09277 1435356013658 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1435356013659 substrate binding site [chemical binding]; other site 1435356013660 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1435356013661 ligand binding site [chemical binding]; other site 1435356013662 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1435356013663 substrate binding site [chemical binding]; other site 1435356013664 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1435356013665 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1435356013666 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 1435356013667 putative dimerization interface [polypeptide binding]; other site 1435356013668 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1435356013669 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1435356013670 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1435356013671 NAD(P) binding site [chemical binding]; other site 1435356013672 Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile. CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902 1435356013673 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1435356013674 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 1435356013675 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 1435356013676 DDE superfamily endonuclease; Region: DDE_5; pfam13546 1435356013677 Transposase; Region: HTH_Tnp_1; pfam01527 1435356013678 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1435356013679 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1435356013680 NAD(P) binding site [chemical binding]; other site 1435356013681 catalytic residues [active] 1435356013682 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1435356013683 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1435356013684 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1435356013685 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1435356013686 ligand binding site [chemical binding]; other site 1435356013687 homodimer interface [polypeptide binding]; other site 1435356013688 NAD(P) binding site [chemical binding]; other site 1435356013689 trimer interface B [polypeptide binding]; other site 1435356013690 trimer interface A [polypeptide binding]; other site 1435356013691 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1435356013692 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1435356013693 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1435356013694 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1435356013695 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1435356013696 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1435356013697 DNA binding site [nucleotide binding] 1435356013698 domain linker motif; other site 1435356013699 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1435356013700 dimerization interface [polypeptide binding]; other site 1435356013701 ligand binding site [chemical binding]; other site 1435356013702 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1435356013703 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1435356013704 Protein of unknown function (DUF993); Region: DUF993; pfam06187 1435356013705 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1435356013706 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1435356013707 Transcription factor WhiB; Region: Whib; pfam02467 1435356013708 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1435356013709 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1435356013710 active site 1435356013711 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1435356013712 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1435356013713 Strictosidine synthase; Region: Str_synth; pfam03088 1435356013714 DUF35 OB-fold domain; Region: DUF35; pfam01796 1435356013715 thiolase; Provisional; Region: PRK06158 1435356013716 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1435356013717 active site 1435356013718 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1435356013719 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1435356013720 DNA-binding site [nucleotide binding]; DNA binding site 1435356013721 FCD domain; Region: FCD; pfam07729 1435356013722 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1435356013723 benzoate transport; Region: 2A0115; TIGR00895 1435356013724 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356013725 putative substrate translocation pore; other site 1435356013726 metabolite-proton symporter; Region: 2A0106; TIGR00883 1435356013727 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356013728 putative substrate translocation pore; other site 1435356013729 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1435356013730 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1435356013731 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1435356013732 acyl-activating enzyme (AAE) consensus motif; other site 1435356013733 AMP binding site [chemical binding]; other site 1435356013734 active site 1435356013735 CoA binding site [chemical binding]; other site 1435356013736 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1435356013737 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1435356013738 NAD(P) binding site [chemical binding]; other site 1435356013739 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1435356013740 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1435356013741 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 1435356013742 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1435356013743 NAD binding site [chemical binding]; other site 1435356013744 catalytic residues [active] 1435356013745 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1435356013746 putative CoA-transferase; Provisional; Region: PRK11430 1435356013747 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1435356013748 FAD binding domain; Region: FAD_binding_4; pfam01565 1435356013749 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1435356013750 transposase/IS protein; Provisional; Region: PRK09183 1435356013751 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1435356013752 Walker A motif; other site 1435356013753 ATP binding site [chemical binding]; other site 1435356013754 Walker B motif; other site 1435356013755 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1435356013756 Helix-turn-helix domain; Region: HTH_38; pfam13936 1435356013757 Integrase core domain; Region: rve; pfam00665 1435356013758 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 1435356013759 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1435356013760 dimer interface [polypeptide binding]; other site 1435356013761 PYR/PP interface [polypeptide binding]; other site 1435356013762 TPP binding site [chemical binding]; other site 1435356013763 substrate binding site [chemical binding]; other site 1435356013764 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1435356013765 TPP-binding site [chemical binding]; other site 1435356013766 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1435356013767 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1435356013768 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1435356013769 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1435356013770 Helix-turn-helix domain; Region: HTH_18; pfam12833 1435356013771 Nitronate monooxygenase; Region: NMO; pfam03060 1435356013772 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1435356013773 FMN binding site [chemical binding]; other site 1435356013774 substrate binding site [chemical binding]; other site 1435356013775 putative catalytic residue [active] 1435356013776 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 1435356013777 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1435356013778 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1435356013779 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1435356013780 dimerization interface [polypeptide binding]; other site 1435356013781 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1435356013782 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1435356013783 DDE superfamily endonuclease; Region: DDE_5; pfam13546 1435356013784 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1435356013785 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1435356013786 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1435356013787 active site 1435356013788 metal binding site [ion binding]; metal-binding site 1435356013789 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1435356013790 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1435356013791 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1435356013792 Zn2+ binding site [ion binding]; other site 1435356013793 Mg2+ binding site [ion binding]; other site 1435356013794 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1435356013795 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1435356013796 DNA binding residues [nucleotide binding] 1435356013797 dimerization interface [polypeptide binding]; other site 1435356013798 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1435356013799 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1435356013800 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1435356013801 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1435356013802 rod shape-determining protein MreB; Provisional; Region: PRK13930 1435356013803 MreB and similar proteins; Region: MreB_like; cd10225 1435356013804 nucleotide binding site [chemical binding]; other site 1435356013805 Mg binding site [ion binding]; other site 1435356013806 putative protofilament interaction site [polypeptide binding]; other site 1435356013807 RodZ interaction site [polypeptide binding]; other site 1435356013808 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1435356013809 dimerization interface [polypeptide binding]; other site 1435356013810 putative DNA binding site [nucleotide binding]; other site 1435356013811 putative Zn2+ binding site [ion binding]; other site 1435356013812 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1435356013813 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1435356013814 DNA-binding site [nucleotide binding]; DNA binding site 1435356013815 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1435356013816 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1435356013817 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356013818 putative substrate translocation pore; other site 1435356013819 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1435356013820 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1435356013821 active site residue [active] 1435356013822 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1435356013823 active site residue [active] 1435356013824 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 1435356013825 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 1435356013826 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1435356013827 active site 1435356013828 nucleotide binding site [chemical binding]; other site 1435356013829 HIGH motif; other site 1435356013830 KMSKS motif; other site 1435356013831 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1435356013832 phosphoenolpyruvate synthase; Validated; Region: PRK06241 1435356013833 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1435356013834 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1435356013835 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1435356013836 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1435356013837 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1435356013838 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1435356013839 siderophore binding site; other site 1435356013840 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1435356013841 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1435356013842 ABC-ATPase subunit interface; other site 1435356013843 dimer interface [polypeptide binding]; other site 1435356013844 putative PBP binding regions; other site 1435356013845 FecCD transport family; Region: FecCD; pfam01032 1435356013846 dimer interface [polypeptide binding]; other site 1435356013847 putative PBP binding regions; other site 1435356013848 ABC-ATPase subunit interface; other site 1435356013849 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1435356013850 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1435356013851 Walker A/P-loop; other site 1435356013852 ATP binding site [chemical binding]; other site 1435356013853 Q-loop/lid; other site 1435356013854 ABC transporter signature motif; other site 1435356013855 Walker B; other site 1435356013856 D-loop; other site 1435356013857 H-loop/switch region; other site 1435356013858 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1435356013859 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1435356013860 DNA binding site [nucleotide binding] 1435356013861 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 1435356013862 DNA polymerase IV; Validated; Region: PRK03352 1435356013863 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1435356013864 active site 1435356013865 DNA binding site [nucleotide binding] 1435356013866 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1435356013867 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1435356013868 Walker A/P-loop; other site 1435356013869 ATP binding site [chemical binding]; other site 1435356013870 Q-loop/lid; other site 1435356013871 ABC transporter signature motif; other site 1435356013872 Walker B; other site 1435356013873 D-loop; other site 1435356013874 H-loop/switch region; other site 1435356013875 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1435356013876 Walker A/P-loop; other site 1435356013877 ATP binding site [chemical binding]; other site 1435356013878 Q-loop/lid; other site 1435356013879 ABC transporter signature motif; other site 1435356013880 Walker B; other site 1435356013881 D-loop; other site 1435356013882 H-loop/switch region; other site 1435356013883 Cobalt transport protein; Region: CbiQ; cl00463 1435356013884 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1435356013885 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1435356013886 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1435356013887 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1435356013888 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356013889 putative substrate translocation pore; other site 1435356013890 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1435356013891 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1435356013892 dimer interface [polypeptide binding]; other site 1435356013893 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1435356013894 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1435356013895 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1435356013896 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 1435356013897 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1435356013898 Helix-turn-helix domain; Region: HTH_18; pfam12833 1435356013899 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1435356013900 TIGR03086 family protein; Region: TIGR03086 1435356013901 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1435356013902 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 1435356013903 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1435356013904 nudix motif; other site 1435356013905 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 1435356013906 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 1435356013907 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194 1435356013908 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1435356013909 putative active site [active] 1435356013910 metal binding site [ion binding]; metal-binding site 1435356013911 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1435356013912 hydrophobic ligand binding site; other site 1435356013913 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1435356013914 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 1435356013915 elongation factor G; Reviewed; Region: PRK12740 1435356013916 G1 box; other site 1435356013917 putative GEF interaction site [polypeptide binding]; other site 1435356013918 GTP/Mg2+ binding site [chemical binding]; other site 1435356013919 Switch I region; other site 1435356013920 G2 box; other site 1435356013921 G3 box; other site 1435356013922 Switch II region; other site 1435356013923 G4 box; other site 1435356013924 G5 box; other site 1435356013925 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1435356013926 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 1435356013927 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1435356013928 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1435356013929 Flavodoxin; Region: Flavodoxin_1; pfam00258 1435356013930 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1435356013931 FAD binding pocket [chemical binding]; other site 1435356013932 FAD binding motif [chemical binding]; other site 1435356013933 catalytic residues [active] 1435356013934 NAD binding pocket [chemical binding]; other site 1435356013935 phosphate binding motif [ion binding]; other site 1435356013936 beta-alpha-beta structure motif; other site 1435356013937 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 1435356013938 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1435356013939 active site 1435356013940 dimer interface [polypeptide binding]; other site 1435356013941 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1435356013942 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1435356013943 active site 1435356013944 FMN binding site [chemical binding]; other site 1435356013945 substrate binding site [chemical binding]; other site 1435356013946 3Fe-4S cluster binding site [ion binding]; other site 1435356013947 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 1435356013948 domain_subunit interface; other site 1435356013949 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1435356013950 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 1435356013951 NAD binding site [chemical binding]; other site 1435356013952 catalytic residues [active] 1435356013953 Chorismate mutase type II; Region: CM_2; cl00693 1435356013954 putative acyltransferase; Provisional; Region: PRK05790 1435356013955 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1435356013956 dimer interface [polypeptide binding]; other site 1435356013957 active site 1435356013958 TIGR02680 family protein; Region: TIGR02680 1435356013959 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1435356013960 Protein of unknown function (DUF2398); Region: DUF2398; cl09875 1435356013961 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 1435356013962 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1435356013963 MarR family; Region: MarR_2; pfam12802 1435356013964 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1435356013965 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1435356013966 acyl-activating enzyme (AAE) consensus motif; other site 1435356013967 putative AMP binding site [chemical binding]; other site 1435356013968 putative active site [active] 1435356013969 putative CoA binding site [chemical binding]; other site 1435356013970 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1435356013971 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1435356013972 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1435356013973 putative ADP-ribose binding site [chemical binding]; other site 1435356013974 putative active site [active] 1435356013975 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; cl17722 1435356013976 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 1435356013977 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1435356013978 Ferredoxin [Energy production and conversion]; Region: COG1146 1435356013979 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1435356013980 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1435356013981 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1435356013982 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1435356013983 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1435356013984 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1435356013985 substrate binding pocket [chemical binding]; other site 1435356013986 catalytic triad [active] 1435356013987 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1435356013988 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1435356013989 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1435356013990 Walker A/P-loop; other site 1435356013991 ATP binding site [chemical binding]; other site 1435356013992 Q-loop/lid; other site 1435356013993 ABC transporter signature motif; other site 1435356013994 Walker B; other site 1435356013995 D-loop; other site 1435356013996 H-loop/switch region; other site 1435356013997 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1435356013998 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 1435356013999 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1435356014000 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129 1435356014001 catalytic triad [active] 1435356014002 active site nucleophile [active] 1435356014003 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1435356014004 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1435356014005 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1435356014006 HIT family signature motif; other site 1435356014007 catalytic residue [active] 1435356014008 NAD-dependent deacetylase; Provisional; Region: PRK00481 1435356014009 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1435356014010 NAD+ binding site [chemical binding]; other site 1435356014011 substrate binding site [chemical binding]; other site 1435356014012 Zn binding site [ion binding]; other site 1435356014013 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1435356014014 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1435356014015 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1435356014016 ligand binding site [chemical binding]; other site 1435356014017 homodimer interface [polypeptide binding]; other site 1435356014018 NAD(P) binding site [chemical binding]; other site 1435356014019 trimer interface B [polypeptide binding]; other site 1435356014020 trimer interface A [polypeptide binding]; other site 1435356014021 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1435356014022 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1435356014023 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1435356014024 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1435356014025 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1435356014026 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1435356014027 E3 interaction surface; other site 1435356014028 lipoyl attachment site [posttranslational modification]; other site 1435356014029 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1435356014030 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1435356014031 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1435356014032 alpha subunit interface [polypeptide binding]; other site 1435356014033 TPP binding site [chemical binding]; other site 1435356014034 heterodimer interface [polypeptide binding]; other site 1435356014035 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1435356014036 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1435356014037 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1435356014038 TPP-binding site [chemical binding]; other site 1435356014039 heterodimer interface [polypeptide binding]; other site 1435356014040 tetramer interface [polypeptide binding]; other site 1435356014041 phosphorylation loop region [posttranslational modification] 1435356014042 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1435356014043 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1435356014044 AsnC family; Region: AsnC_trans_reg; pfam01037 1435356014045 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1435356014046 active site 1435356014047 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1435356014048 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1435356014049 active site residue [active] 1435356014050 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1435356014051 active site residue [active] 1435356014052 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 1435356014053 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1435356014054 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1435356014055 shikimate binding site; other site 1435356014056 NAD(P) binding site [chemical binding]; other site 1435356014057 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1435356014058 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1435356014059 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1435356014060 putative NAD(P) binding site [chemical binding]; other site 1435356014061 SNF2 Helicase protein; Region: DUF3670; pfam12419 1435356014062 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1435356014063 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1435356014064 ATP binding site [chemical binding]; other site 1435356014065 putative Mg++ binding site [ion binding]; other site 1435356014066 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1435356014067 nucleotide binding region [chemical binding]; other site 1435356014068 ATP-binding site [chemical binding]; other site 1435356014069 Uncharacterized conserved protein [Function unknown]; Region: COG4279 1435356014070 SWIM zinc finger; Region: SWIM; pfam04434 1435356014071 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 1435356014072 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1435356014073 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1435356014074 tetrameric interface [polypeptide binding]; other site 1435356014075 NAD binding site [chemical binding]; other site 1435356014076 catalytic residues [active] 1435356014077 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1435356014078 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 1435356014079 substrate binding pocket [chemical binding]; other site 1435356014080 FAD binding site [chemical binding]; other site 1435356014081 catalytic base [active] 1435356014082 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1435356014083 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1435356014084 substrate binding site [chemical binding]; other site 1435356014085 oxyanion hole (OAH) forming residues; other site 1435356014086 trimer interface [polypeptide binding]; other site 1435356014087 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1435356014088 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1435356014089 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1435356014090 enoyl-CoA hydratase; Provisional; Region: PRK05862 1435356014091 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1435356014092 substrate binding site [chemical binding]; other site 1435356014093 oxyanion hole (OAH) forming residues; other site 1435356014094 trimer interface [polypeptide binding]; other site 1435356014095 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1435356014096 MarR family; Region: MarR; pfam01047 1435356014097 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 1435356014098 short chain dehydrogenase; Provisional; Region: PRK07890 1435356014099 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1435356014100 NAD(P) binding site [chemical binding]; other site 1435356014101 active site 1435356014102 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1435356014103 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1435356014104 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 1435356014105 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1435356014106 CysD dimerization site [polypeptide binding]; other site 1435356014107 G1 box; other site 1435356014108 putative GEF interaction site [polypeptide binding]; other site 1435356014109 GTP/Mg2+ binding site [chemical binding]; other site 1435356014110 Switch I region; other site 1435356014111 G2 box; other site 1435356014112 G3 box; other site 1435356014113 Switch II region; other site 1435356014114 G4 box; other site 1435356014115 G5 box; other site 1435356014116 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1435356014117 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1435356014118 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1435356014119 ligand-binding site [chemical binding]; other site 1435356014120 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1435356014121 active site 1435356014122 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1435356014123 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1435356014124 SnoaL-like domain; Region: SnoaL_3; pfam13474 1435356014125 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1435356014126 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 1435356014127 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1435356014128 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1435356014129 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1435356014130 active site 1435356014131 HIGH motif; other site 1435356014132 KMSK motif region; other site 1435356014133 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1435356014134 tRNA binding surface [nucleotide binding]; other site 1435356014135 anticodon binding site; other site 1435356014136 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1435356014137 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1435356014138 active site 1435356014139 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1435356014140 substrate binding site [chemical binding]; other site 1435356014141 catalytic residues [active] 1435356014142 dimer interface [polypeptide binding]; other site 1435356014143 homoserine dehydrogenase; Provisional; Region: PRK06349 1435356014144 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1435356014145 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1435356014146 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1435356014147 threonine synthase; Reviewed; Region: PRK06721 1435356014148 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1435356014149 homodimer interface [polypeptide binding]; other site 1435356014150 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1435356014151 catalytic residue [active] 1435356014152 homoserine kinase; Provisional; Region: PRK01212 1435356014153 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1435356014154 transcription termination factor Rho; Provisional; Region: PRK12608 1435356014155 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1435356014156 RNA binding site [nucleotide binding]; other site 1435356014157 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1435356014158 multimer interface [polypeptide binding]; other site 1435356014159 Walker A motif; other site 1435356014160 ATP binding site [chemical binding]; other site 1435356014161 Walker B motif; other site 1435356014162 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1435356014163 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1435356014164 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1435356014165 RF-1 domain; Region: RF-1; pfam00472 1435356014166 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1435356014167 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1435356014168 S-adenosylmethionine binding site [chemical binding]; other site 1435356014169 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1435356014170 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1435356014171 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1435356014172 Mg++ binding site [ion binding]; other site 1435356014173 putative catalytic motif [active] 1435356014174 substrate binding site [chemical binding]; other site 1435356014175 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1435356014176 ATP synthase subunit C; Region: ATP-synt_C; cl00466 1435356014177 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1435356014178 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1435356014179 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 1435356014180 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1435356014181 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1435356014182 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1435356014183 beta subunit interaction interface [polypeptide binding]; other site 1435356014184 Walker A motif; other site 1435356014185 ATP binding site [chemical binding]; other site 1435356014186 Walker B motif; other site 1435356014187 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1435356014188 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1435356014189 core domain interface [polypeptide binding]; other site 1435356014190 delta subunit interface [polypeptide binding]; other site 1435356014191 epsilon subunit interface [polypeptide binding]; other site 1435356014192 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1435356014193 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1435356014194 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1435356014195 alpha subunit interaction interface [polypeptide binding]; other site 1435356014196 Walker A motif; other site 1435356014197 ATP binding site [chemical binding]; other site 1435356014198 Walker B motif; other site 1435356014199 inhibitor binding site; inhibition site 1435356014200 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1435356014201 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1435356014202 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1435356014203 gamma subunit interface [polypeptide binding]; other site 1435356014204 epsilon subunit interface [polypeptide binding]; other site 1435356014205 LBP interface [polypeptide binding]; other site 1435356014206 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 1435356014207 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1435356014208 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1435356014209 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1435356014210 hinge; other site 1435356014211 active site